BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.2226.p (1369 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PA2402_1 [Q] COG1020 Non-ribosomal peptide synthetase modules an... 925 0.0 PA2402_3 [Q] COG1020 Non-ribosomal peptide synthetase modules an... 868 0.0 PA2424_2 [Q] COG1020 Non-ribosomal peptide synthetase modules an... 852 0.0 PA2399_1 [Q] COG1020 Non-ribosomal peptide synthetase modules an... 848 0.0 PA2399_2 [Q] COG1020 Non-ribosomal peptide synthetase modules an... 830 0.0 >PA2402_1 [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins Pae Pseudomonas aeruginosa Length = 1541 Score = 925 bits (2391), Expect = 0.0, Method: Compositional matrix adjust. Identities = 522/1103 (47%), Positives = 696/1103 (63%), Gaps = 43/1103 (3%) Query: 1 MNA-SQYDIARRFALLPGEKKTAFLAALKSRGIDFGRLPI-VKAAAADRSALSYAQARQW 58 MNA +ARRF LP EK+ FL L+ GIDF PI ++A+R LSYAQ R W Sbjct: 1 MNAEDSLKLARRFIELPVEKRRVFLETLRGEGIDFSLFPIPAGVSSAERDRLSYAQQRMW 60 Query: 59 FLWQLDRESSAYHLSTAMQLQGELDLPLLQQCFNALVARHASLRTRFGCDAQGGAYQEVL 118 FLW L+ +S AY+L +A++L G LD L++ F +LV RH +LRT F A Q L Sbjct: 61 FLWHLEPQSGAYNLPSAVRLNGPLDRQALERAFASLVQRHETLRTVFPRGADDSLAQAPL 120 Query: 119 P---QGEFEFCLCDYRHSQPPSLAELVGQQAQQLYQRPFDLEHGPLLRVGVIRESEQQQV 175 + FE C Q L E +AQ+ +PFDL GPLLRV +IR E++ V Sbjct: 121 QRPLEVAFEDCSGLPEDEQEARLRE----EAQRESLQPFDLCEGPLLRVRLIRLGEERHV 176 Query: 176 LVVVMHHIVSDGWSMEILLREFIELYRG---GREPSPVQWPSLAIDYADYAAWQRNWLEA 232 L++ +HHIVSDGWSM +L+ EF Y G EP P+L I YADYA WQR+WLEA Sbjct: 177 LLLTLHHIVSDGWSMNVLIEEFSRFYSAYATGAEPG---LPALPIQYADYALWQRSWLEA 233 Query: 233 GERDRQIAYWRAQLGEHHPVLQLPVDHPRREDGHYSAATHRLTLPRALAEALPGRAQTAG 292 GE++RQ+ YWR +LGE HPVL+LP DHPR Y + + ++ ALAEAL G A+ G Sbjct: 234 GEQERQLEYWRGKLGERHPVLELPTDHPRPAVPSYRGSRYEFSIEPALAEALRGTARRQG 293 Query: 293 ATVFMVLLAALQSLLFRYAGDGDIRVGVPVANRRRAEIEDLVGFFVNTQVVRAGMSDAMS 352 T+FM+LL LL RY+G D+RVGVP+ANR RAE+E L+G FVNTQV+R+ S Sbjct: 294 LTLFMLLLGGFNILLQRYSGQTDLRVGVPIANRNRAEVEGLIGLFVNTQVLRSVFDGRTS 353 Query: 353 LQQVLEGARHAVIEAQAHQDLPFEQLVEALQPDRSSGMAPLFQVLFNHQS--AHGNGSLT 410 + +L G + V+ AQAHQDLPFE+LVEA + +RS +PLFQV++NHQ A + Sbjct: 354 VATLLAGLKDTVLGAQAHQDLPFERLVEAFKVERSLSHSPLFQVMYNHQPLVADIEALDS 413 Query: 411 LPGLQAQEYILPGKRAQFELVIDSVDDGEGGIAIDFIYASELFSAVRMERMARHYLSLLE 470 + GL + + QF+L +D+ + G G + YA++LF A +ERMARH+ +LL Sbjct: 414 VAGLSFGQLDWKSRTTQFDLSLDTYEKG-GRLYAALTYATDLFEARTVERMARHWQNLLR 472 Query: 471 ALVWQPGRRIGDIDLLQEQER-QALQQWDGSLWRAELGPAAPVPVHQQFSRIAQEQ---- 525 ++ P + + +L +ER Q L+ W+ + AA P+ + R+ +EQ Sbjct: 473 GMLENPQASVDSLPMLDAEERGQLLEGWNAT--------AAEYPLQRGVHRLFEEQVERT 524 Query: 526 PDAVAVLFGQQHLSYGELEQRANQLAHHLLAHGAGPETRVGIAVERSLEMIVGLLAILKT 585 P A A+ FG++ L Y EL +RAN+LAH L+ G G + VG+A+ERS+EM+V L+AILK Sbjct: 525 PTAPALAFGEERLDYAELNRRANRLAHALIERGVGADRLVGVAMERSIEMVVALMAILKA 584 Query: 586 GAAYVPLDMDYPAERLAYIAADSGFALLITHSRLRQRLVPDRGVQVIELDRLQ--LQALP 643 G AYVP+D +YP ER AY+ DSG LL++ S L+ L +GVQ I+LD+ L+ Sbjct: 585 GGAYVPVDPEYPEERQAYMLEDSGVQLLLSQSHLKLPLA--QGVQRIDLDQADAWLENHA 642 Query: 644 VTPPMVALHPDNLAYVIYTSGSTGQPKGAAIGHGALAHCMGWMQRRYALSAQDAVLHKAP 703 P V L+ +NLAYVIYTSGSTG+PKGA H AL++ + WMQ+ Y L D VL K P Sbjct: 643 ENNPGVELNGENLAYVIYTSGSTGKPKGAGNRHSALSNRLCWMQQAYGLGVGDTVLQKTP 702 Query: 704 FGFDVSVWEIFWPLTAGTRLVLAAPGEQKDPERITELIRRHGITTLNFVPSMLQAFLSHD 763 F FDVSVWE FWPL +G RLV+AAPG+ +DP ++ ELI R G+ TL+FVPSMLQAFL + Sbjct: 703 FSFDVSVWEFFWPLMSGARLVVAAPGDHRDPAKLVELINREGVDTLHFVPSMLQAFLQDE 762 Query: 764 GIEQQTRLRYVICGGESMPAATQAEALRRLAGVSLQNLYGPTETTIHVSQWSCRDDGRSL 823 + T L+ ++C GE++PA Q + +L L NLYGPTE I V+ W+C ++G+ Sbjct: 763 DVASCTSLKRIVCSGEALPADAQQQVFAKLPQAGLYNLYGPTEAAIDVTHWTCVEEGKDA 822 Query: 824 VPIGRPIFATSAQVLDGALNPVPLGVAGELYIGGALLGRGYLGRAALTAERFVADPGDPD 883 VPIGRPI + +LDG L PVP+GV GELY+ G L RGY R LTAERFVA P Sbjct: 823 VPIGRPIANLACYILDGNLEPVPVGVLGELYLAGRGLARGYHQRPGLTAERFVASPFVA- 881 Query: 884 GGRLYRTGDLVRWNGQGQLEYLGRIDHQVKIRGLRIELGEVEAQLLAQEALREAVVITQP 943 G R+YRTGDL R+ G +EY GRIDHQVK+RGLRIELGE+EA+LL +REA V+ Sbjct: 882 GERMYRTGDLARYRADGVIEYAGRIDHQVKLRGLRIELGEIEARLLEHPWVREAAVL--- 938 Query: 944 AADGLRLVAYVSPRAGNMVTPTQIREQLGQRLPAYMVPDAVVVLPTLPLNANGKVDRKAL 1003 A DG +LV YV + + L LP YMVP + L +PL+ NGK+DRKAL Sbjct: 939 AVDGKQLVGYVVLESEGGDWREALAAHLATSLPEYMVPAQWLALERMPLSPNGKLDRKAL 998 Query: 1004 PPAQWSSTRH-YVAPEGPIEQALAQIWSEVLGIERIGRDDNFFELGGHSISALRVVGLAR 1062 P + S + Y AP +E+ LA+IW ++LG+E++G DDNFF LGG SI +++VV +R Sbjct: 999 PAPEVSVAQAGYSAPRNAVERTLAEIWQDLLGVEQVGLDDNFFSLGGDSIVSIQVV--SR 1056 Query: 1063 ARQLPGLPLTLRELLSAPSLREL 1085 ARQ GL L+ R+L ++R L Sbjct: 1057 ARQ-AGLQLSPRDLFQHQNIRSL 1078 Score = 67.8 bits (164), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 80/271 (29%), Positives = 120/271 (44%), Gaps = 19/271 (7%) Query: 50 LSYAQARQWFLWQLDRESSAYHLSTAMQLQGELDLPLLQQCFNALVARHASLRTRFGCDA 109 ++ A ++WF Q ++ S +Q + LD L + L A+H +LR RF Sbjct: 1098 VALAPVQRWFFEQSIPNRQHWNQSLLLQARQPLDGDRLGRALERLQAQHDALRLRF--RE 1155 Query: 110 QGGAYQEVLPQGEFEFCLCDYRHSQPPSLAELVGQQAQQLYQRPFDLEHGPLLRVGVIRE 169 + GA+ + + E S+ LA + ++AQ R DLE GPLLR ++ Sbjct: 1156 ERGAWHQAYAEQAGEPLWRRQAGSEEVLLA--LCEEAQ----RSLDLEQGPLLRALLVDM 1209 Query: 170 SEQQQVLVVVMHHIVSDGWSMEILLREFIELYRGGREPSPVQWPSLAIDYADYAAWQRNW 229 ++ Q L++V+HH+ DG S ILL + LY L + Y AW R+ Sbjct: 1210 ADGSQRLLLVIHHLAVDGVSWRILLEDLQRLYADLD-------ADLGPRSSSYQAWSRHL 1262 Query: 230 LE-AGERDRQIAYWRAQLGEHHPVLQLPVDHPRREDGHYSAATHRLTLPRALAEALPGRA 288 E AG R ++ YW+AQL H LP ++P + LTL L A Sbjct: 1263 HEQAGARLDELDYWQAQL--HDAPHALPCENPHGALENRHERKLVLTLDAERTRQLLQEA 1320 Query: 289 QTAGAT-VFMVLLAALQSLLFRYAGDGDIRV 318 A T V +LL AL R++GD + V Sbjct: 1321 PAAYRTQVNDLLLTALARATCRWSGDASVLV 1351 >PA2402_3 [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins Pae Pseudomonas aeruginosa Length = 1495 Score = 868 bits (2244), Expect = 0.0, Method: Compositional matrix adjust. Identities = 481/1045 (46%), Positives = 658/1045 (62%), Gaps = 31/1045 (2%) Query: 50 LSYAQARQWFLWQLDRESSAYHLSTAMQLQGELDLPLLQQCFNALVARHASLRTRFGCDA 109 LS+AQ R WFLW+L+ ES+AYHL + + ++G LD LQQ F+ LV RH +LRTRF + Sbjct: 6 LSHAQQRMWFLWKLEPESAAYHLPSVLHVRGVLDQAALQQAFDWLVLRHETLRTRFE-EV 64 Query: 110 QGGAYQEVLPQGEFEFCLCDYRHSQPPSLAELVGQQAQQLYQRPFDLEHGPLLRVGVIRE 169 G A Q +L L D + +L + V ++ +Q PFDL GPLLRV ++ Sbjct: 65 DGQARQTILANMPLRIVLEDCAGASEATLRQRVAEEIRQ----PFDLARGPLLRVRLLAL 120 Query: 170 SEQQQVLVVVMHHIVSDGWSMEILLREFIELYRGGREPSPVQWPSLAIDYADYAAWQRNW 229 + Q+ VLV+ HHIVSDGWSM++++ E ++ Y R L + YADYAAW R W Sbjct: 121 AGQEHVLVITQHHIVSDGWSMQVMVDELLQAYAAARRGEQPTLAPLTLQYADYAAWHRAW 180 Query: 230 LEAGERDRQIAYWRAQLGEHHPVLQLPVDHPRREDGHYSAATHRLTLPRALAEALPGRAQ 289 L++GE RQ+ YWR +LG PVL+LP D R + LP +L+E L A+ Sbjct: 181 LDSGEGARQLDYWRERLGAEQPVLELPADRVRPAQASGRGQRLDMALPVSLSEELLACAR 240 Query: 290 TAGATVFMVLLAALQSLLFRYAGDGDIRVGVPVANRRRAEIEDLVGFFVNTQVVRAGMSD 349 G T FM+LLA+ Q LL RY+G DIRVGVP+ANR RAE+E L+GFFVNTQV+R + Sbjct: 241 REGVTPFMLLLASFQVLLKRYSGQSDIRVGVPIANRNRAEVERLIGFFVNTQVLRCQVDA 300 Query: 350 AMSLQQVLEGARHAVIEAQAHQDLPFEQLVEALQPDRSSGMAPLFQVLFNHQSAHGNGSL 409 ++ + +L R A + AQAHQDLPFEQLV+ALQP+R+ +PLFQV++NHQS + Sbjct: 301 GLAFRDLLGRVREAALGAQAHQDLPFEQLVDALQPERNLSHSPLFQVMYNHQSGERQDA- 359 Query: 410 TLPGLQAQEYILPGKRAQFELVIDSVDDGEGGIAIDFIYASELFSAVRMERMARHYLSLL 469 + GL + + G AQF+L +D+ + +G + YA++LF A +ERMARH+ +LL Sbjct: 360 QVDGLHIESFAWDGAAAQFDLALDTWETPDG-LGAALTYATDLFEARTVERMARHWQNLL 418 Query: 470 EALVWQPGRRIGDIDLLQEQER-QALQQWDGSLWRAELGPAAPVPVHQQFSRIAQEQ--- 525 ++ P + + +L +ER Q L+ W+ + AA P+ + R+ +EQ Sbjct: 419 RGMLENPQASVDSLPMLDAEERGQLLEGWNAT--------AAEYPLQRGVHRLFEEQVER 470 Query: 526 -PDAVAVLFGQQHLSYGELEQRANQLAHHLLAHGAGPETRVGIAVERSLEMIVGLLAILK 584 P A A+ FG++ L Y EL +RAN+LAH L+ G G + VG+A+ERS+EM+V L+AILK Sbjct: 471 TPTAPALAFGEERLDYAELNRRANRLAHALIERGVGADRLVGVAMERSIEMVVALMAILK 530 Query: 585 TGAAYVPLDMDYPAERLAYIAADSGFALLITHSRLRQRLVPDRGVQVIELDRLQ--LQAL 642 G AYVP+D +YP ER AY+ DSG LL++ S L+ L +GVQ I+LD+ L+ Sbjct: 531 AGGAYVPVDPEYPEERQAYMLEDSGVQLLLSQSHLKLPLA--QGVQRIDLDQADAWLENH 588 Query: 643 PVTPPMVALHPDNLAYVIYTSGSTGQPKGAAIGHGALAHCMGWMQRRYALSAQDAVLHKA 702 P + L+ +NLAYVIYTSGSTG+PKGA H AL++ + WMQ+ Y L D VL K Sbjct: 589 AENNPGIELNGENLAYVIYTSGSTGKPKGAGNRHSALSNRLCWMQQAYGLGVGDTVLQKT 648 Query: 703 PFGFDVSVWEIFWPLTAGTRLVLAAPGEQKDPERITELIRRHGITTLNFVPSMLQAFLSH 762 PF FDVSVWE FWPL +G RLV+AAPG+ +DP ++ LI R G+ TL+FVPSMLQAFL Sbjct: 649 PFSFDVSVWEFFWPLMSGARLVVAAPGDHRDPAKLVALINREGVDTLHFVPSMLQAFLQD 708 Query: 763 DGIEQQTRLRYVICGGESMPAATQAEALRRLAGVSLQNLYGPTETTIHVSQWSCRDDGRS 822 + + T L+ ++C GE++ A Q + +L L NLYGPTE I V+ WSC ++G+ Sbjct: 709 EDVVSCTSLKRIVCSGEALSADAQQQVFAKLPQAGLYNLYGPTEAAIDVTHWSCVEEGKD 768 Query: 823 LVPIGRPIFATSAQVLDGALNPVPLGVAGELYIGGALLGRGYLGRAALTAERFVADPGDP 882 VPIGRPI +LDG L PVP+GV GELY+ G L RGY R LTAERFVA P Sbjct: 769 AVPIGRPIANLGCYILDGDLEPVPVGVLGELYLAGRGLARGYHQRPGLTAERFVASPFVA 828 Query: 883 DGGRLYRTGDLVRWNGQGQLEYLGRIDHQVKIRGLRIELGEVEAQLLAQEALREAVVITQ 942 G R+YRTGDL R+ G +EY GRIDHQVK+RGLRIELGE+EA+LL +REA V+ Sbjct: 829 -GERMYRTGDLARYRADGVIEYAGRIDHQVKLRGLRIELGEIEARLLEHPWVREAAVL-- 885 Query: 943 PAADGLRLVAYVSPRAGNMVTPTQIREQLGQRLPAYMVPDAVVVLPTLPLNANGKVDRKA 1002 A D +LV YV + + L LP YMVP + L +PL+ NGK+DRKA Sbjct: 886 -AVDSRQLVGYVVLESEGGDWREALAAHLATSLPEYMVPAQWLALERMPLSPNGKLDRKA 944 Query: 1003 LPPAQWSSTRHYVAPEGPIEQALAQIWSEVLGIERIGRDDNFFELGGHSISALRVVGLAR 1062 LP Q ++ + +VAP+ +E+ +A +W++VL +E +G DNFF LGG SI +++VV R Sbjct: 945 LPRPQAAAGQTHVAPQNEMERRIAAVWADVLKLEEVGATDNFFALGGDSIVSIQVVSRCR 1004 Query: 1063 ARQLPGLPLTLRELLSAPSLRELAR 1087 A G+ T ++L +++ LAR Sbjct: 1005 A---AGIQFTPKDLFQQQTVQGLAR 1026 Score = 65.9 bits (159), Expect = 7e-10, Method: Compositional matrix adjust. Identities = 107/410 (26%), Positives = 179/410 (43%), Gaps = 36/410 (8%) Query: 82 LDLPLLQQCFNALVARHASLRTRFGCDAQGGAYQEVLPQGEFEFCLCDYRHSQPPSLAEL 141 L+ L+ ALV H +LR RF G + + L +R AE Sbjct: 1077 LNAKALEAALQALVEHHDALRLRF--HETDGTWHAEHAEATLGGALL-WR-------AEA 1126 Query: 142 VGQQAQQLY----QRPFDLEHGPLLRVGVIRESEQQQVLVVVMHHIVSDGWSMEILLREF 197 V +QA + QR DL GPLLR ++ ++ Q L++V+HH+V DG S ILL + Sbjct: 1127 VDRQALESLCEESQRSLDLADGPLLRSLLVDMADGGQRLLLVIHHLVVDGVSWRILLEDL 1186 Query: 198 IELYRGGREPSPVQWPSLAIDYADYAAWQRNWLEAGERDRQIAYWRAQLGEHHPVLQLPV 257 Y+ + P + +A Q+ +WR +L E P +LP Sbjct: 1187 QRAYQQSLRGEAPRLPGKTSPFKAWAGRVSEHARGESMKAQLQFWR-ELLEGAPA-ELPC 1244 Query: 258 DHPRREDGHYSAATHRLTLPRALAEALPGRAQTAGAT-VFMVLLAALQSLLFRYAGDGDI 316 +HP+ A + + R+L E L +A A T V +LL AL ++ R++G Sbjct: 1245 EHPQGALEQRFATSVQSRFDRSLTERLLKQAPAAYRTQVNDLLLTALARVVCRWSGASSS 1304 Query: 317 RVGVPVANRRR----AEIEDLVGFFVNTQVVRAGMSDAMSLQQVLEGARHAVIEAQAHQD 372 V + R ++ VG+F + VR +S L + L+ + + A + Sbjct: 1305 LVQLEGHGREELFADIDLSRTVGWFTSLFPVR--LSPVADLGESLKAIKEQ-LRAIPDKG 1361 Query: 373 LPFEQLVEALQPDRSSGM---APLFQVLFNH----QSAHGNGSLTLP-GLQAQEYILPGK 424 L + L+ L + S+ + P ++ FN+ + +L P G A + PG Sbjct: 1362 LGY-GLLRYLAGEESARVLAGLPQARITFNYLGQFDAQFDEMALLDPAGESAGAEMDPGA 1420 Query: 425 RAQFELVIDS-VDDGEGGIAIDFIYASELFSAVRMERMARHYLSLLEALV 473 L ++ V DGE ++ID+ ++S++F ++ R+A Y++ L ALV Sbjct: 1421 PLDNWLSLNGRVFDGE--LSIDWSFSSQMFGEDQVRRLADDYVAELTALV 1468 >PA2424_2 [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins Pae Pseudomonas aeruginosa Length = 1050 Score = 852 bits (2202), Expect = 0.0, Method: Compositional matrix adjust. Identities = 483/1037 (46%), Positives = 628/1037 (60%), Gaps = 21/1037 (2%) Query: 51 SYAQARQWFLWQLDRESSAYHLSTAMQLQGELDLPLLQQCFNALVARHASLRTRFGCDAQ 110 S AQ R W WQ+D +S+AY++ ++L+GELD L+ F LV RH +LRTRF + Sbjct: 8 SAAQQRLWLTWQIDPQSAAYNIPGGLRLRGELDEAALRASFQRLVERHEALRTRF-LERD 66 Query: 111 GGAYQEVLPQGEFEFCLCDYRHSQPPSLAELVGQQAQQLYQRPFDLEHGPLLRVGVIRES 170 G A Q + +GEF + D A Q+ + Q+PFDLE GPLLRV ++R Sbjct: 67 GAALQRIDERGEFAWQFVDLAALAEHERAAAAAQRREAEAQQPFDLEKGPLLRVSLVRLD 126 Query: 171 EQQQVLVVVMHHIVSDGWSMEILLREFIELYRGGREPSPVQWPSLAIDYADYAAWQRNWL 230 EQ+ L V +HHIV+DGWS+ +LL EF LY P L + YA++AAWQR WL Sbjct: 127 EQEHQLWVTLHHIVADGWSLNLLLDEFSRLYAEACGGQPADLAPLELHYAEFAAWQRQWL 186 Query: 231 EAGERDRQIAYWRAQLGEHHPVLQLPVDHPRREDGHYSAATHRLTLPRALAEALPGRAQT 290 +AGE RQ+AYWR +LG+ PVL+L DHPR AA + L + ALA A+ A Sbjct: 187 DAGEGARQLAYWRERLGDTAPVLELATDHPRTARQASPAARYSLRVDEALARAIREAALD 246 Query: 291 AGATVFMVLLAALQSLLFRYAGDGDIRVGVPVANRRRAEIEDLVGFFVNTQVVRAGMSDA 350 A+VFM LLAA Q+LL R++G G+IR+GVP ANR+R E + LVGFF+NT V+R Sbjct: 247 HEASVFMWLLAAFQALLHRHSGQGEIRIGVPSANRQRLETQGLVGFFINTLVLRGTPRAR 306 Query: 351 MSLQQVLEGARHAVIEAQAHQDLPFEQLVEALQPDRSSGMAPLFQVLFNHQSAHGNGSLT 410 +L AR A + AQA+QDLPF+Q++ A LFQVLFNHQ + Sbjct: 307 QPFAALLGEAREATLGAQANQDLPFDQVLAA-----CGQGGQLFQVLFNHQQRDLSALRR 361 Query: 411 LPGLQAQEYILPGKRAQFELVIDSVDDGEGGIAIDFIYASELFSAVRMERMARHYLSLLE 470 LPGL A E + A+F+L + S +D G + ++F YA++LF + R A YL LL Sbjct: 362 LPGLLADELPWHSREAKFDLQLQSEEDARGRLTLNFDYAADLFDEASIRRFAAQYLELLR 421 Query: 471 ALVWQPGRRIGDIDLLQEQERQALQQWDGSLWRAELGPAAPVP--VHQQFSRIAQEQPDA 528 + P R +GDI L+ ++ L +W + P P + + R + + Sbjct: 422 QVAEDPQRCLGDIALVDAEQAAHLAEWGSA-------PCEPARAWLPELLERQLAQSAER 474 Query: 529 VAVLFGQQHLSYGELEQRANQLAHHLLAHGAGPETRVGIAVERSLEMIVGLLAILKTGAA 588 VA+ + L Y EL RAN+LAH+L G GP+ RV I ERS +++VGLLAI+K G A Sbjct: 475 VALEWDGGSLGYAELHARANRLAHYLRDKGVGPDVRVAICAERSPQLLVGLLAIVKAGGA 534 Query: 589 YVPLDMDYPAERLAYIAADSGFALLITHSRLRQRLVPDRGVQVIELDRLQLQALPVTPPM 648 YVPLD DYP+ERLAY+ ADSG LL+T + L +RL GV I LD L+L P P Sbjct: 535 YVPLDPDYPSERLAYMLADSGVELLLTQAHLFERLPGAEGVTPICLDSLKLDNWPSQAPG 594 Query: 649 VALHPDNLAYVIYTSGSTGQPKGAAIGHGALAHCMGWMQRRYALSAQDAVLHKAPFGFDV 708 + LH DNLAYVIYTSGSTGQPKG H ALA + WMQ Y L D ++ KAP FDV Sbjct: 595 LHLHGDNLAYVIYTSGSTGQPKGVGNTHAALAERLQWMQATYTLDGDDVLMQKAPVSFDV 654 Query: 709 SVWEIFWPLTAGTRLVLAAPGEQKDPERITELIRRHGITTLNFVPSMLQAFLSHDGIEQQ 768 SVWE FWPL G RLVLAAPGE +DP R+ EL+R+ G+TTL+FVP +LQ F+ G+ Sbjct: 655 SVWECFWPLVTGCRLVLAAPGEHRDPARLVELVRQFGVTTLHFVPPLLQLFIDEPGVAAC 714 Query: 769 TRLRYVICGGESMPAATQAEALRRLAGVSLQNLYGPTETTIHVSQWSCRDDGRSLVPIGR 828 LR + GGE++PA + L+RL V+L N YGPTET I+V+ W CR + PIGR Sbjct: 715 GSLRRLFSGGEALPAELRNRVLQRLPAVALHNRYGPTETAINVTHWQCRAEDGERSPIGR 774 Query: 829 PIFATSAQVLDGALNPVPLGVAGELYIGGALLGRGYLGRAALTAERFVADPGDPDGGRLY 888 P+ +VLD N +P GVAGEL IGG L RGYLGR AL+AERFVADP G RLY Sbjct: 775 PLGNVVCRVLDAEFNLLPAGVAGELCIGGLGLARGYLGRPALSAERFVADPFSAAGERLY 834 Query: 889 RTGDLVRWNGQGQLEYLGRIDHQVKIRGLRIELGEVEAQLLAQEALREAVVITQPAADGL 948 RTGD RWN G LEYLGR+D QVK+RG RIE E++A+LLAQ + +AVV+ + G Sbjct: 835 RTGDRARWNADGVLEYLGRLDQQVKLRGFRIEPEEIQARLLAQPGVAQAVVVIREGVAGS 894 Query: 949 RLVAYVSPRAGNMVTPTQ---IREQLGQRLPAYMVPDAVVVLPTLPLNANGKVDRKALPP 1005 +LV Y + G Q +R L LP YMVP ++ L +PL +GK+D +ALP Sbjct: 895 QLVGYYTGAVGAEAEAEQNQRLRAALQAELPEYMVPTQLMRLAQMPLGPSGKLDTRALPE 954 Query: 1006 AQWSSTRHYVAPEGPIEQALAQIWSEVLGIERIGRDDNFFELGGHSISALRVVGLARARQ 1065 W R +V P +++ +A IWSEVLG+ R+G D+FFELGGHS+ A R+V +R RQ Sbjct: 955 PVWQQ-REHVEPRTELQRRIAAIWSEVLGLPRVGLRDDFFELGGHSLLATRIV--SRTRQ 1011 Query: 1066 LPGLPLTLRELLSAPSL 1082 + L LR L A L Sbjct: 1012 ACDVELPLRALFEASEL 1028 >PA2399_1 [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins Pae Pseudomonas aeruginosa Length = 1105 Score = 848 bits (2192), Expect = 0.0, Method: Compositional matrix adjust. Identities = 501/1092 (45%), Positives = 662/1092 (60%), Gaps = 30/1092 (2%) Query: 13 ALLPGEKKTAFLAALKSRGID-FGRLPIVKAAAADRSALSYAQARQWFLWQLDRESSAYH 71 +L P E+K A LK +G++ F P+ K + LSYAQ RQWFLWQL+ ES+AYH Sbjct: 10 SLSPQERK-ALAVLLKQQGVNLFEIAPVFKRQDGEPLRLSYAQERQWFLWQLEPESAAYH 68 Query: 72 LSTAMQLQGELDLPLLQQCFNALVARHASLRTRFGCDAQGGAYQEVLPQGEFEFCLCDYR 131 + + ++L+G LDL LQ+ F++LVARH +LRTRF D A QE+ + Sbjct: 69 IPSVLRLRGRLDLDALQRSFDSLVARHETLRTRFRLDGDE-ARQEIAASMALPLDIVALG 127 Query: 132 HSQPPSLAELVGQQAQQLYQRPFDLEHGPLLRVGVIRESEQQQVLVVVMHHIVSDGWSME 191 + +LA +Q + RPFDLE GPLLRV ++R +E VLV+V HHIVSDGWSM+ Sbjct: 128 PLEEGALA----RQVETTIARPFDLERGPLLRVSLLRLAEDDHVLVLVQHHIVSDGWSMQ 183 Query: 192 ILLREFIELYRGGREPSPVQWPSLAIDYADYAAWQRNWLEAGERDRQIAYWRAQLGEHHP 251 +++ E ++LY V P+L I YADYA WQR+W+EAGE++RQ+AYW LG P Sbjct: 184 VMVEELVQLYAAYSRGLEVALPALPIQYADYALWQRSWMEAGEKERQLAYWTGLLGGEQP 243 Query: 252 VLQLPVDHPRREDGHYSAATHRLTLPRALAEALPGRAQTAGATVFMVLLAALQSLLFRYA 311 VL+LP D PR + A L L L++AL AQ GAT F +LLA+ Q+LL+RY+ Sbjct: 244 VLELPFDRPRPVRQSHRGAQFILELDIDLSQALRRVAQQEGATAFALLLASFQALLYRYS 303 Query: 312 GDGDIRVGVPVANRRRAEIEDLVGFFVNTQVVRAGMSDAMSLQQVLEGARHAVIEAQAHQ 371 G DIRVGVP+ANR R E E L+GFFVNTQV++A + M ++L AR +EAQAHQ Sbjct: 304 GQADIRVGVPIANRNRVETERLIGFFVNTQVLKADLDGRMGFDELLAQARQRALEAQAHQ 363 Query: 372 DLPFEQLVEALQPDRSSGMAPLFQVLFNHQS-AHGNG-SLTLPGLQAQEYILPGKRAQFE 429 DLPFEQLVEALQP+RS PLFQVLFN+QS A GNG + LQ + + AQF+ Sbjct: 364 DLPFEQLVEALQPERSLSHNPLFQVLFNYQSEARGNGQAFRFDELQMESVQFDSRTAQFD 423 Query: 430 LVIDSVDDGEGGIAIDFIYASELFSAVRMERMARHYLSLLEALVWQPGRRIGDIDLLQEQ 489 L +D D+ + A+ F YA++LF A +ER+A H+ +LL +V P +R+G++ LL Sbjct: 424 LTLDLTDEEQRFCAV-FDYATDLFDASTVERLAGHWRNLLRGIVANPRQRLGELPLLDAP 482 Query: 490 E-RQALQQWDGSLWRAELGPAAPVPVHQQFSRIAQEQPDAVAVLFGQQHLSYGELEQRAN 548 E RQ L +W+ A+ A + Q+F A+++P AVA++ +Q LSYGEL RAN Sbjct: 483 ERRQTLSEWNP----AQRECAVQGTLQQRFEEQARQRPQAVALILDEQRLSYGELNARAN 538 Query: 549 QLAHHLLAHGAGPETRVGIAVERSLEMIVGLLAILKTGAAYVPLDMDYPAERLAYIAADS 608 +LAH L+A G G + VG+A+ERSL+M+VGLLAILK G AY+PLD P ERLA+I DS Sbjct: 539 RLAHCLIARGVGADVPVGLALERSLDMLVGLLAILKAGGAYLPLDPAAPEERLAHILDDS 598 Query: 609 GFALLITHSRLRQRLVPDRGVQVIELDRLQLQALPVTPPMVALHPDNLAYVIYTSGSTGQ 668 G LL+T L +RL GV+V+ +D L L + P+ L DNLAYVIYTSGSTG+ Sbjct: 599 GVRLLLTQGHLLERLPRQAGVEVLAIDGLVLDGYAESDPLPTLSADNLAYVIYTSGSTGK 658 Query: 669 PKGAAIGHGALAHCMGWMQRRYALSAQDAVLHKAPFGFDVSVWEIFWPLTAGTRLVLAAP 728 PKG + H + + +D + FD SVWEIF L G LV+ Sbjct: 659 PKGTLLTHRNALRLFSATEAWFGFDERDVWTLFHSYAFDFSVWEIFGALLYGGCLVIVPQ 718 Query: 729 GEQKDPERITELIRRHGITTLNFVPSMLQAFL----SHDGIEQQTRLRYVICGGESMPAA 784 + PE L+ R G+T LN PS + + S D QQ LRYVI GGE++ Sbjct: 719 WVSRSPEDFYRLLCREGVTVLNQTPSAFKQLMAVACSADMATQQPALRYVIFGGEALDLQ 778 Query: 785 TQAEALRRLAGVSLQ--NLYGPTETTIHVSQWSCRD---DGRSLVPIGRPIFATSAQVLD 839 + +R Q N+YG TETT+HV+ + +G + PIG I S +LD Sbjct: 779 SLRPWFQRFGDRQPQLVNMYGITETTVHVTYRPVSEADLEGGLVSPIGGTIPDLSWYILD 838 Query: 840 GALNPVPLGVAGELYIGGALLGRGYLGRAALTAERFVADPGDPDGG-RLYRTGDLVRWNG 898 LNPVP G GELYIG A L RGYL R L+A RFV +P G RLYRTGDL R+ Sbjct: 839 RDLNPVPRGAVGELYIGRAGLARGYLRRPGLSATRFVPNPFPGGAGERLYRTGDLARFQA 898 Query: 899 QGQLEYLGRIDHQVKIRGLRIELGEVEAQLLAQEALREAVVITQPAADGLRLVAYVSPRA 958 G +EY+GRIDHQVK+RG RIELGE+EA L +R+AVV+ G +LV YV + Sbjct: 899 DGNIEYIGRIDHQVKVRGFRIELGEIEAALAGLAGVRDAVVLAHDGVGGTQLVGYVVADS 958 Query: 959 GNMVTPTQ--IREQLGQRLPAYMVPDAVVVLPTLPLNANGKVDRKALP-PAQWSSTRHYV 1015 + +RE L + LP YMVP +++L +PL NGK+DR+ALP P S + Y Sbjct: 959 AEDAERLRESLRESLKRHLPDYMVPAHLMLLERMPLTVNGKLDRQALPQPDASLSQQAYR 1018 Query: 1016 APEGPIEQALAQIWSEVLGIERIGRDDNFFELGGHSISALRVVGLARARQLPGLPLTLRE 1075 AP +EQ +A IWSE+LG+ER+G DDNFFELGGHS+ A RV+ +R RQ L +L+ Sbjct: 1019 APGSELEQRIAAIWSEILGVERVGLDDNFFELGGHSLLATRVI--SRVRQEQQLDASLKA 1076 Query: 1076 LLSAPSLRELAR 1087 L P L A+ Sbjct: 1077 LFERPVLEAFAQ 1088 >PA2399_2 [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins Pae Pseudomonas aeruginosa Length = 1060 Score = 830 bits (2143), Expect = 0.0, Method: Compositional matrix adjust. Identities = 475/1020 (46%), Positives = 633/1020 (62%), Gaps = 29/1020 (2%) Query: 49 ALSYAQARQWFLWQLDRESSAYHLSTAMQLQGELDLPLLQQCFNALVARHASLRTRFGCD 108 ALS+AQ RQWFLWQL+ ES+AYH+ +A++L+G LD+ LQ+ F++LVARH +LRTRF + Sbjct: 5 ALSFAQERQWFLWQLEPESAAYHIPSALRLRGRLDVDALQRSFDSLVARHETLRTRFRLE 64 Query: 109 AQGGAYQEVLPQGEFEFCLCDYRHSQPPSLAELVGQQAQQLYQRPFDLEHGPLLRVGVIR 168 G +YQ+V P + E + ++ Q + +PFDLE GPLLRV +++ Sbjct: 65 G-GRSYQQVQPAVSVSIEREQFGE-------EGLIERIQAIVVQPFDLERGPLLRVNLLQ 116 Query: 169 ESEQQQVLVVVMHHIVSDGWSMEILLREFIELYRGGREPSPVQWPSLAIDYADYAAWQRN 228 +E VLV+V HHIVSDGWSM++++ E ++LY + V P+L I YADYA WQR+ Sbjct: 117 LAEDDHVLVLVQHHIVSDGWSMQVMVEELVQLYAAYSQGLDVVLPALPIQYADYALWQRS 176 Query: 229 WLEAGERDRQIAYWRAQLGEHHPVLQLPVDHPRREDGHYSAATHRLTLPRALAEALPGRA 288 W+EAGE++RQ+AYW LG PVL+LP D PR + A L R L EA+ A Sbjct: 177 WMEAGEKERQLAYWTGLLGGEQPVLELPFDRPRPARQSHRGAQLGFELSRELVEAVRALA 236 Query: 289 QTAGATVFMVLLAALQSLLFRYAGDGDIRVGVPVANRRRAEIEDLVGFFVNTQVVRAGMS 348 Q GA+ FM+LLA+ Q+LL+RY+G DIRVGVP+ANR R E E L+GFFVNTQV++A + Sbjct: 237 QREGASSFMLLLASFQALLYRYSGQADIRVGVPIANRNRVETERLIGFFVNTQVLKADLD 296 Query: 349 DAMSLQQVLEGARHAVIEAQAHQDLPFEQLVEALQPDRSSGMAPLFQVLFNHQSAHGNGS 408 M ++L AR +EAQAHQDLPFEQLVEALQP+R++ PLFQVLFNHQS + + Sbjct: 297 GRMGFDELLAQARQRALEAQAHQDLPFEQLVEALQPERNASHNPLFQVLFNHQSEIRSVT 356 Query: 409 --LTLPGLQAQEYILPGKRAQFELVIDSVDDGEGGIAIDFIYASELFSAVRMERMARHYL 466 + L L+ + G+ AQF+L +D +D E GI F YA++LF A +ER+A H+ Sbjct: 357 PEVQLEDLRLEGLAWDGQTAQFDLTLDIQED-ENGIWASFDYATDLFDASTVERLAGHWR 415 Query: 467 SLLEALVWQPGRRIGDIDLLQEQE-RQALQQWDGSLWRAELGPAAPVPVHQQFSRIAQEQ 525 +LL +V P +R+G++ LL E RQ L +W+ A+ A + Q+F A+++ Sbjct: 416 NLLRGIVANPRQRLGELPLLDAPERRQTLSEWNP----AQRECAVQGTLQQRFEEQARQR 471 Query: 526 PDAVAVLFGQQHLSYGELEQRANQLAHHLLAHGAGPETRVGIAVERSLEMIVGLLAILKT 585 P AVA++ +Q LSYGEL RAN+LAH L+A G G + VG+A+ERSL+M+VGLLAILK Sbjct: 472 PQAVALILDEQRLSYGELNARANRLAHCLIARGVGADVPVGLALERSLDMLVGLLAILKA 531 Query: 586 GAAYVPLDMDYPAERLAYIAADSGFALLITHSRLRQRLVPDRGVQVIELDRLQLQALPVT 645 G AY+PLD P ERLA+I DSG LL+T L +RL GV+V+ +D L L + Sbjct: 532 GGAYLPLDPAAPEERLAHILDDSGVRLLLTQGHLLERLPRQAGVEVLAIDGLVLDGYAES 591 Query: 646 PPMVALHPDNLAYVIYTSGSTGQPKGAAIGHGALAHCMGWMQRRYALSAQDAVLHKAPFG 705 P+ L DNLAYVIYTSGSTG+PKG + H + + +D + Sbjct: 592 DPLPTLSADNLAYVIYTSGSTGKPKGTLLTHRNALRLFSATEAWFGFDERDVWTLFHSYA 651 Query: 706 FDVSVWEIFWPLTAGTRLVLAAPGEQKDPERITELIRRHGITTLNFVPSMLQAFL----S 761 FD SVWEIF L G RLV+ + PE L+ R G+T LN PS + + S Sbjct: 652 FDFSVWEIFGALLYGGRLVIVPQWVSRSPEDFYRLLCREGVTVLNQTPSAFKQLMAVACS 711 Query: 762 HDGIEQQTRLRYVICGGESMPAATQAEALRRLAGV--SLQNLYGPTETTIHVSQWSCRD- 818 D QQ LRYVI GGE++ + +R L N+YG TETT+HV+ + Sbjct: 712 ADMATQQPALRYVIFGGEALDLQSLRPWFQRFGDRQPQLVNMYGITETTVHVTYRPVSEA 771 Query: 819 --DGRSLVPIGRPIFATSAQVLDGALNPVPLGVAGELYIGGALLGRGYLGRAALTAERFV 876 G + PIG I S +LD LNPVP G GELYIG A L RGYL R L+A RFV Sbjct: 772 DLKGGLVSPIGGTIPDLSWYILDRDLNPVPRGAVGELYIGRAGLARGYLRRPGLSATRFV 831 Query: 877 ADPGDPDGG-RLYRTGDLVRWNGQGQLEYLGRIDHQVKIRGLRIELGEVEAQLLAQEALR 935 +P G RLYRTGDL R+ G +EY+GRIDHQVK+RG RIELGE+EA L +R Sbjct: 832 PNPFPGGAGERLYRTGDLARFQADGNIEYIGRIDHQVKVRGFRIELGEIEAALAGLAGVR 891 Query: 936 EAVVITQPAADGLRLVAYVSPRAGNMVTPTQ--IREQLGQRLPAYMVPDAVVVLPTLPLN 993 +AVV+ G +LV YV + + +RE L + LP YMVP +++L +PL Sbjct: 892 DAVVLAHDGVGGTQLVGYVVADSAEDAERLRESLRESLKRHLPDYMVPAHLMLLERMPLT 951 Query: 994 ANGKVDRKALP-PAQWSSTRHYVAPEGPIEQALAQIWSEVLGIERIGRDDNFFELGGHSI 1052 NGK+DR+ALP P S + Y AP +EQ +A IW+E+LG+ER+G DDNFFELGGHS+ Sbjct: 952 VNGKLDRQALPQPDASLSQQAYRAPGSELEQRIAAIWAEILGVERVGLDDNFFELGGHSL 1011