BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.2225.p (3675 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PA2402_1 [Q] COG1020 Non-ribosomal peptide synthetase modules an... 1384 0.0 PA2402_3 [Q] COG1020 Non-ribosomal peptide synthetase modules an... 1332 0.0 PA2424_3 [Q] COG1020 Non-ribosomal peptide synthetase modules an... 1123 0.0 PA2400 [Q] COG1020 Non-ribosomal peptide synthetase modules and ... 983 0.0 all2644_2 [Q] COG1020 Non-ribosomal peptide synthetase modules a... 890 0.0 >PA2402_1 [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins Pae Pseudomonas aeruginosa Length = 1541 Score = 1384 bits (3582), Expect = 0.0, Method: Compositional matrix adjust. Identities = 773/1563 (49%), Positives = 1008/1563 (64%), Gaps = 45/1563 (2%) Query: 3 NTPDLPQRRAQLSAEQRSRLQQRLRGNGAKGSGDAAAALPF-ATRAPGTPAPLSFAQQRL 61 ++ L +R +L E+R + LRG G S P A + LS+AQQR+ Sbjct: 5 DSLKLARRFIELPVEKRRVFLETLRGEGIDFS-----LFPIPAGVSSAERDRLSYAQQRM 59 Query: 62 WYLWKLTPQSSAYHLAGGLRLQGPLEAAALERAVDALALHHPALRTVLREDADGNVTQTV 121 W+LW L PQS AY+L +RL GPL+ ALERA +L H LRTV AD ++ Q Sbjct: 60 WFLWHLEPQSGAYNLPSAVRLNGPLDRQALERAFASLVQRHETLRTVFPRGADDSLAQAP 119 Query: 122 LPACAWSLSRQDLSLLPAHRRQDALREQVQRLCSRPFELDGGALVRACLLQVDEQEHQLI 181 L ++ +D S LP ++ LRE+ QR +PF+L G L+R L+++ E+ H L+ Sbjct: 120 LQR-PLEVAFEDCSGLPEDEQEARLREEAQRESLQPFDLCEGPLLRVRLIRLGEERHVLL 178 Query: 182 VVMHHIISDAQSTQLILAELLALYQAARQGQAISAAWHGPDLGDYAVWQRQCLNSTQAER 241 + +HHI+SD S +++ E Y A G DYA+WQR L + + ER Sbjct: 179 LTLHHIVSDGWSMNVLIEEFSRFYSAYATGAEPGLPALPIQYADYALWQRSWLEAGEQER 238 Query: 242 QLAWWKAQLGNSSPVLELPTDHARRPDGQYGAASWRIVLEPALLDALRRRAQGQGCSLFV 301 QL +W+ +LG PVLELPTDH R Y + + +EPAL +ALR A+ QG +LF+ Sbjct: 239 QLEYWRGKLGERHPVLELPTDHPRPAVPSYRGSRYEFSIEPALAEALRGTARRQGLTLFM 298 Query: 302 VLLCAFQALLYRHTSQRDVRVGVPVSHRLRSELAAAVGFFVDTQVLRAELAGQTTLESLL 361 +LL F LL R++ Q D+RVGVP+++R R+E+ +G FV+TQVLR+ G+T++ +LL Sbjct: 299 LLLGGFNILLQRYSGQTDLRVGVPIANRNRAEVEGLIGLFVNTQVLRSVFDGRTSVATLL 358 Query: 362 AQVRDTSFAAQAHRDIPLERLVEVLQPERSIGRTPLFQVMFNH--LREQADGSQSWPGLS 419 A ++DT AQAH+D+P ERLVE + ERS+ +PLFQVM+NH L + S GLS Sbjct: 359 AGLKDTVLGAQAHQDLPFERLVEAFKVERSLSHSPLFQVMYNHQPLVADIEALDSVAGLS 418 Query: 420 VQRLDFDAAVAQFELTLETSEEANGELSATFRYARELFDESSIARMAQHYVAILQALATQ 479 +LD+ + QF+L+L+T E+ G L A YA +LF+ ++ RMA+H+ +L+ + Sbjct: 419 FGQLDWKSRTTQFDLSLDTYEKG-GRLYAALTYATDLFEARTVERMARHWQNLLRGMLEN 477 Query: 480 PQLRVAELQLRGAEEDRQL-HSWGVNNEQHAEVMEPVHEQIARQARRQPEATALLFGRQQ 538 PQ V L + AEE QL W ++ + VH Q R P A AL FG ++ Sbjct: 478 PQASVDSLPMLDAEERGQLLEGWNATAAEYP-LQRGVHRLFEEQVERTPTAPALAFGEER 536 Query: 539 LSYGALERRANQLAHRLIRLGAGPEVKVGIAVERSLEMVIGLLGILKAGAAYVPLDPEYP 598 L Y L RRAN+LAH LI G G + VG+A+ERS+EMV+ L+ ILKAG AYVP+DPEYP Sbjct: 537 LDYAELNRRANRLAHALIERGVGADRLVGVAMERSIEMVVALMAILKAGGAYVPVDPEYP 596 Query: 599 AQRLQYMMQDSGMRLLLTQQHVLPTLPPLAGLPVLALDQLD--LDDEAHQPPAVRVHGEN 656 +R YM++DSG++LLL+Q H+ LP G+ + LDQ D L++ A P V ++GEN Sbjct: 597 EERQAYMLEDSGVQLLLSQSHL--KLPLAQGVQRIDLDQADAWLENHAENNPGVELNGEN 654 Query: 657 LAYVIYTSGSTGQPKGVANRHCALRNRLAWMQQAYRLEPHDTVLQKTPFSFDVSVWEFFW 716 LAYVIYTSGSTG+PKG NRH AL NRL WMQQAY L DTVLQKTPFSFDVSVWEFFW Sbjct: 655 LAYVIYTSGSTGKPKGAGNRHSALSNRLCWMQQAYGLGVGDTVLQKTPFSFDVSVWEFFW 714 Query: 717 PLMIGARLALAQPGDHRDPARLVEQIQRHAVSTLHFVPSMLQAFLAHDEIEGCSSLHRLI 776 PLM GARL +A PGDHRDPA+LVE I R V TLHFVPSMLQAFL +++ C+SL R++ Sbjct: 715 PLMSGARLVVAAPGDHRDPAKLVELINREGVDTLHFVPSMLQAFLQDEDVASCTSLKRIV 774 Query: 777 CSGEALPVEAQQGVFARLPQVALYNLYGPTEAAIDVTHWTCRADGRSQVPIGRPISSIRT 836 CSGEALP +AQQ VFA+LPQ LYNLYGPTEAAIDVTHWTC +G+ VPIGRPI+++ Sbjct: 775 CSGEALPADAQQQVFAKLPQAGLYNLYGPTEAAIDVTHWTCVEEGKDAVPIGRPIANLAC 834 Query: 837 LVLDGDLNLAPQGVPGELYLGGIGLARGYLGRAGLSAERFVADPFSADGERLYRTGDLVR 896 +LDG+L P GV GELYL G GLARGY R GL+AERFVA PF A GER+YRTGDL R Sbjct: 835 YILDGNLEPVPVGVLGELYLAGRGLARGYHQRPGLTAERFVASPFVA-GERMYRTGDLAR 893 Query: 897 WNREGQLDYLGRLDHQVKIRGLRIELGEIEARLLAQPGVREAVVVARESAGTSRLVAYV- 955 + +G ++Y GR+DHQVK+RGLRIELGEIEARLL P VREA V+A + +LV YV Sbjct: 894 YRADGVIEYAGRIDHQVKLRGLRIELGEIEARLLEHPWVREAAVLAVDG---KQLVGYVV 950 Query: 956 ---SGTDLVAATLRSALTKDLPDYMVPALIEVLEHLPLNANGKVDRRALPDPAQPL-QRA 1011 G D A L + L LP+YMVPA LE +PL+ NGK+DR+ALP P + Q Sbjct: 951 LESEGGDWREA-LAAHLATSLPEYMVPAQWLALERMPLSPNGKLDRKALPAPEVSVAQAG 1009 Query: 1012 YEAPRGQAEQVLAAVWAEVLGLQQVGRHDNFFELGGDSILSLQIVAGLRRRGSQLAPRLI 1071 Y APR E+ LA +W ++LG++QVG DNFF LGGDSI+S+Q+V+ R+ G QL+PR + Sbjct: 1010 YSAPRNAVERTLAEIWQDLLGVEQVGLDDNFFSLGGDSIVSIQVVSRARQAGLQLSPRDL 1069 Query: 1072 FERQTIAQLAPAIAHSTAPQLHAQVSVQGELPLLPIQAEFFAMDIPVRHHWNQSILLATD 1131 F+ Q I LA A A Q GE+ L P+Q FF IP R HWNQS+LL Sbjct: 1070 FQHQNIRSLALAAKAGAATA--EQGPASGEVALAPVQRWFFEQSIPNRQHWNQSLLLQAR 1127 Query: 1132 APLDMAALNTALQAVVAHHDSLRLRYTRDDQGQWRQTYGQHDPAQLRELLWVRQGLPGNA 1191 PLD L AL+ + A HD+LRLR+ R+++G W Q Y + Q E LW RQ Sbjct: 1128 QPLDGDRLGRALERLQAQHDALRLRF-REERGAWHQAYAE----QAGEPLWRRQAGSEEV 1182 Query: 1192 IAPLCEQAQRSLNLARGPLLRAVAMELEEGGWRLLLVIHHLVVDGVSWRILLADLQQAYR 1251 + LCE+AQRSL+L +GPLLRA+ +++ +G RLLLVIHHL VDGVSWRILL DLQ+ Y Sbjct: 1183 LLALCEEAQRSLDLEQGPLLRALLVDMADGSQRLLLVIHHLAVDGVSWRILLEDLQRLYA 1242 Query: 1252 QCVALEPLVLPARTASYQQWAHVLQGRHGALLPQRPYWQAQMQ-PPSVLPCDDAGGEATM 1310 A L R++SYQ W+ L + GA L + YWQAQ+ P LPC++ G Sbjct: 1243 DLDA----DLGPRSSSYQAWSRHLHEQAGARLDELDYWQAQLHDAPHALPCENPHGALEN 1298 Query: 1311 RQRQEMSFGLDKERTNALLRRVPAAYRTRINDVLLTALVRALCGWSGLSEIQVDIEGHGR 1370 R +++ LD ERT LL+ PAAYRT++ND+LLTAL RA C WSG + + V +EGHGR Sbjct: 1299 RHERKLVLTLDAERTRQLLQEAPAAYRTQVNDLLLTALARATCRWSGDASVLVQLEGHGR 1358 Query: 1371 EDGTGQLDLSRTVGWFTSVFPLRLSGAGTPQQALKRIKESLRAVPEAGLGFGLLRQ---- 1426 ED +DLSRTVGWFTS+FPLRL+ A ++LK IKE LR VP+ G+G+GLLR Sbjct: 1359 EDLGEAIDLSRTVGWFTSLFPLRLTPAADLGESLKAIKEQLRGVPDKGVGYGLLRYLAGE 1418 Query: 1427 --AGNLPGSSSSPVIFNYLGQFDASFDGTSGWRPAQEESGAAIDPDAPMQHEFAVEGQVY 1484 A L + FNYLG+FD FDG + PA E +GAA DP AP+ + ++EGQVY Sbjct: 1419 EAATRLAALPQPRITFNYLGRFDRQFDGAALLVPATESAGAAQDPCAPLANWLSIEGQVY 1478 Query: 1485 DGQLLINVAYSGKRYARASVQAWVERFEQELDALITHCTSGAC-GATPSDFPLAGLDQTA 1543 G+L ++ ++S + +A A+VQ V+ + +EL ALI HC G TPSDFPLAGL QT Sbjct: 1479 GGELSLHWSFSREMFAEATVQRLVDDYARELHALIEHCLDPRHRGVTPSDFPLAGLSQTQ 1538 Query: 1544 IDQ 1546 +D+ Sbjct: 1539 LDE 1541 Score = 768 bits (1984), Expect = 0.0, Method: Compositional matrix adjust. Identities = 460/1068 (43%), Positives = 632/1068 (59%), Gaps = 46/1068 (4%) Query: 2594 IMPLP----PAQRNGLLPASYAQARQWFLWQLDPGSSAYHINGALRLCGTLDEAALEQAF 2649 + P+P A+R+ L SYAQ R WFLW L+P S AY++ A+RL G LD ALE+AF Sbjct: 37 LFPIPAGVSSAERDRL---SYAQQRMWFLWHLEPQSGAYNLPSAVRLNGPLDRQALERAF 93 Query: 2650 SRLLERHPSLRTVLRADADGQVLQW-VQPHACLAFKRIDLEPLAEGPRQARLHAEVASLC 2708 + L++RH +LRTV AD + Q +Q +AF+ D L E ++ARL E Sbjct: 94 ASLVQRHETLRTVFPRGADDSLAQAPLQRPLEVAFE--DCSGLPEDEQEARLREEAQRES 151 Query: 2709 RQPFDLEAGPLLRIGLLRESGHRHVLVMVMHHIISDGWSMQLIMDEFASLYGACCQGREA 2768 QPFDL GPLLR+ L+R RHVL++ +HHI+SDGWSM ++++EF+ Y A G E Sbjct: 152 LQPFDLCEGPLLRVRLIRLGEERHVLLLTLHHIVSDGWSMNVLIEEFSRFYSAYATGAEP 211 Query: 2769 GLPALPLQYADYAAWQRQWMQGGQRETQLRYWQDHLGQSQPSLLLPADHPRRPDGLYRAA 2828 GLPALP+QYADYA WQR W++ G++E QL YW+ LG+ P L LP DHPR YR + Sbjct: 212 GLPALPIQYADYALWQRSWLEAGEQERQLEYWRGKLGERHPVLELPTDHPRPAVPSYRGS 271 Query: 2829 RHEAVLPPPLVAALRQRVQSDGGTLFAVLLAAAQLLMYRYSGQNDIRLGVPIANRHLPDT 2888 R+E + P L ALR + G TLF +LL +L+ RYSGQ D+R+GVPIANR+ + Sbjct: 272 RYEFSIEPALAEALRGTARRQGLTLFMLLLGGFNILLQRYSGQTDLRVGVPIANRNRAEV 331 Query: 2889 EGVVGFFVNTQVLRAEIDPRQSLARLVQLTRETAQGAQQHQDLPFEQLVEVLQPQRLVGV 2948 EG++G FVNTQVLR+ D R S+A L+ ++T GAQ HQDLPFE+LVE + +R + Sbjct: 332 EGLIGLFVNTQVLRSVFDGRTSVATLLAGLKDTVLGAQAHQDLPFERLVEAFKVERSLSH 391 Query: 2949 NPLFQVMFNHQRHARPTS--HQLPQLTLEPFELEEQDAQFELAIDTLEDTDGGLSVSLTY 3006 +PLFQVM+NHQ + L+ + + + QF+L++DT E G L +LTY Sbjct: 392 SPLFQVMYNHQPLVADIEALDSVAGLSFGQLDWKSRTTQFDLSLDTYE-KGGRLYAALTY 450 Query: 3007 ARELFEPQTMATMASHYLVALEALASQPQCRVGEIDWLGPAERSR-LAAWGDKVSPYATP 3065 A +LFE +T+ MA H+ L + PQ V + L ER + L W + Y Sbjct: 451 ATDLFEARTVERMARHWQNLLRGMLENPQASVDSLPMLDAEERGQLLEGWNATAAEYPLQ 510 Query: 3066 AVITTRIAQRASIQPDAVALISGNRSMSYGQLNTRVNQLAHYLLQRGLQPEARVGVALER 3125 + ++ P A AL G + Y +LN R N+LAH L++RG+ + VGVA+ER Sbjct: 511 RGVHRLFEEQVERTPTAPALAFGEERLDYAELNRRANRLAHALIERGVGADRLVGVAMER 570 Query: 3126 SADMVVAVLAILKAGATYVPLDPDYPVQRLAAIIEDSALSLLLSQTSVSQRLPGGRAEQT 3185 S +MVVA++AILKAG YVP+DP+YP +R A ++EDS + LLLSQ+ + +LP + Q Sbjct: 571 SIEMVVALMAILKAGGAYVPVDPEYPEERQAYMLEDSGVQLLLSQSHL--KLPLAQGVQR 628 Query: 3186 LYLDQLD--LQAQPHDEPDVTIHSDSLAYVIYTSGSTGRPKGVGISHRCLMEHGQIAADF 3243 + LDQ D L+ + P V ++ ++LAYVIYTSGSTG+PKG G H L Sbjct: 629 IDLDQADAWLENHAENNPGVELNGENLAYVIYTSGSTGKPKGAGNRHSALSNRLCWMQQA 688 Query: 3244 FGLTPQDCMLQFSTLNFDGCIEQLFPPLLVGAAVVLRGP-ELWDSQRLHVELLAHR-ISV 3301 +GL D +LQ + +FD + + F PL+ GA +V+ P + D +L VEL+ + Sbjct: 689 YGLGVGDTVLQKTPFSFDVSVWEFFWPLMSGARLVVAAPGDHRDPAKL-VELINREGVDT 747 Query: 3302 LDLTTAYWLLLVQDFARMGVPDYGVLRRVHVGGEAMPPEGIKAWRDAGLAQVELFNTYGP 3361 L + +QD V L+R+ GEA+P + + A L Q L+N YGP Sbjct: 748 LHFVPSMLQAFLQD---EDVASCTSLKRIVCSGEALPADAQQQ-VFAKLPQAGLYNLYGP 803 Query: 3362 TEATVTASILSCAPYVSGQTVLPAQMPIGAPLAGRKLRVLDAELSPLPIGVAGELCIGGE 3421 TEA + + +C G+ +PIG P+A +LD L P+P+GV GEL + G Sbjct: 804 TEAAIDVTHWTCVE--EGKDA----VPIGRPIANLACYILDGNLEPVPVGVLGELYLAGR 857 Query: 3422 LLARGYLNQPGLSAERFVADPLGDGGARLYRTGDLVRWTHAGQLEYLGRIDHQVKIRGFR 3481 LARGY +PGL+AERFVA P G R+YRTGDL R+ G +EY GRIDHQVK+RG R Sbjct: 858 GLARGYHQRPGLTAERFVASPFV-AGERMYRTGDLARYRADGVIEYAGRIDHQVKLRGLR 916 Query: 3482 IEMGEIESIMLAQPEVREAVVVAREGVGSLQLVAYVTPQHGRHIETAELRECLVRH---- 3537 IE+GEIE+ +L P VREA V+A +G QLV YV + E + RE L H Sbjct: 917 IELGEIEARLLEHPWVREAAVLAVDGK---QLVGYVVLES----EGGDWREALAAHLATS 969 Query: 3538 LPDYMVPAALVVLPALPLNANGKVDRKALPEP-VYESRTGHEPPQGECEQALAAIWAEVL 3596 LP+YMVPA + L +PL+ NGK+DRKALP P V ++ G+ P+ E+ LA IW ++L Sbjct: 970 LPEYMVPAQWLALERMPLSPNGKLDRKALPAPEVSVAQAGYSAPRNAVERTLAEIWQDLL 1029 Query: 3597 GLPAVGRHDNFFELGGHSLSILRIQSRIQQQFPASALPLRSHFDHPTI 3644 G+ VG DNFF LGG S+ +++ SR +Q L R F H I Sbjct: 1030 GVEQVGLDDNFFSLGGDSIVSIQVVSRARQ--AGLQLSPRDLFQHQNI 1075 Score = 489 bits (1260), Expect = e-137, Method: Compositional matrix adjust. Identities = 436/1319 (33%), Positives = 630/1319 (47%), Gaps = 138/1319 (10%) Query: 1560 LSPMQSGMLFHSVSEPDNAAYTMQMQVALEA-LQPERFRAAWQAVLDRHAILRSAILQRD 1618 LS Q M F EP + AY + V L L + A+ +++ RH LR+ + Sbjct: 52 LSYAQQRMWFLWHLEPQSGAYNLPSAVRLNGPLDRQALERAFASLVQRHETLRTVFPRGA 111 Query: 1619 DAPLQWVARRVVLPWQLRDCRHSPD--LAAELDELARREREAGFDLARPPLMRLMLVSTG 1676 D L + L DC P+ A L E A+RE FDL PL+R+ L+ G Sbjct: 112 DDSLAQAPLQRPLEVAFEDCSGLPEDEQEARLREEAQRESLQPFDLCEGPLLRVRLIRLG 171 Query: 1677 EQGYHLIWTVHHLLLDGWSTSQLLGEVLRHYAGQ-TLDEP-----VAAYGDYI----RWL 1726 E+ + L+ T+HH++ DGWS + L+ E R Y+ T EP Y DY WL Sbjct: 172 EERHVLLLTLHHIVSDGWSMNVLIEEFSRFYSAYATGAEPGLPALPIQYADYALWQRSWL 231 Query: 1727 QGRDQQASRHHWQSLLHRLQEPSLLVARLPPAKQPNRAR-DYR--QYTCCLGQAQTRRLV 1783 + +Q+ +W+ L + P L + P P A YR +Y + A L Sbjct: 232 EAGEQERQLEYWRGKLGE-RHPVLEL----PTDHPRPAVPSYRGSRYEFSIEPALAEALR 286 Query: 1784 EFARARHLTLSTLVQAAWALLLQRYAGHGTVCFGATTAGRPMDLAGAESMLGLFINTLPV 1843 AR + LTL L+ + +LLQRY+G + G A R + A E ++GLF+NT + Sbjct: 287 GTARRQGLTLFMLLLGGFNILLQRYSGQTDLRVGVPIANR--NRAEVEGLIGLFVNTQVL 344 Query: 1844 VTTLTPQTALDEWLQQLQRQSAQSREHEYTPL------YEIQRLAGHSGQSLFDTVVVFE 1897 + +T++ L L+ ++ H+ P ++++R HS LF V++ Sbjct: 345 RSVFDGRTSVATLLAGLKDTVLGAQAHQDLPFERLVEAFKVERSLSHS--PLFQ--VMYN 400 Query: 1898 NYPVDAALHS-QEVDKLVVGEVRFSS-GNHYPLTLRV-SLAEQLQIDFLHDTGMIAPELL 1954 + P+ A + + V L G++ + S + L+L +L + T + + Sbjct: 401 HQPLVADIEALDSVAGLSFGQLDWKSRTTQFDLSLDTYEKGGRLYAALTYATDLFEARTV 460 Query: 1955 ARMAAQFTSLLEQFSQD-----------DGETRRRRLADLSLTDLPAPLQGPTIRADDVI 2003 RMA + +LL ++ D E R + L + T PLQ R Sbjct: 461 ERMARHWQNLLRGMLENPQASVDSLPMLDAEERGQLLEGWNATAAEYPLQRGVHRL---- 516 Query: 2004 ERWAAQVSQQPGAAALTDGNHALDMAGLCAWVEQMAQQMRQRGIGCEDRVAIHAERSCAF 2063 + QV + P A AL G LD A L ++A + +RG+G + V + ERS Sbjct: 517 --FEEQVERTPTAPALAFGEERLDYAELNRRANRLAHALIERGVGADRLVGVAMERSIEM 574 Query: 2064 VVAVLATLRVGAAYVPLDPALPAERLHYQLQDSAAVLLLSATAPDWAASVPVLPLA-SLH 2122 VVA++A L+ G AYVP+DP P ER Y L+DS LLLS S LPLA + Sbjct: 575 VVALMAILKAGGAYVPVDPEYPEERQAYMLEDSGVQLLLSQ-------SHLKLPLAQGVQ 627 Query: 2123 GVPKRVPYCWPAVH----PG------QAAYVIYTSGSTGRPKGVVVSRGALANYVAGVLE 2172 + W H PG AYVIYTSGSTG+PKG AL+N + + + Sbjct: 628 RIDLDQADAWLENHAENNPGVELNGENLAYVIYTSGSTGKPKGAGNRHSALSNRLCWMQQ 687 Query: 2173 RLDLREQDRSMAMVSTVGADLGHTVLFGALCSGRLLHLIPPQCSFDPDAMASYMEQHQVD 2232 L D ++ + D+ F L SG L + P DP + + + VD Sbjct: 688 AYGLGVGD-TVLQKTPFSFDVSVWEFFWPLMSGARLVVAAPGDHRDPAKLVELINREGVD 746 Query: 2233 VLKIVPSHLQALLHAASPASVLPRSRLVLGGEASRKPLLAHIASLRPQCRVMNHYGPTET 2292 L VPS LQA L AS R+V GEA + + PQ + N YGPTE Sbjct: 747 TLHFVPSMLQAFLQDEDVASCTSLKRIVCSGEALPADAQQQVFAKLPQAGLYNLYGPTEA 806 Query: 2293 TVGVLTQEASSALDEADSLPIGQPIAQARAYVLDAELQPVPQGVAGELYLAGHGVARAYQ 2352 + V + + D++PIG+PIA Y+LD L+PVP GV GELYLAG G+AR Y Sbjct: 807 AIDV--THWTCVEEGKDAVPIGRPIANLACYILDGNLEPVPVGVLGELYLAGRGLARGYH 864 Query: 2353 QRPAQSAERFVADLLEPGQRMYRSGDRVRQLADGSLEFLGRLDGQIKVRGYRVELREIAA 2412 QRP +AERFVA G+RMYR+GD R ADG +E+ GR+D Q+K+RG R+EL EI A Sbjct: 865 QRPGLTAERFVASPFVAGERMYRTGDLARYRADGVIEYAGRIDHQVKLRGLRIELGEIEA 924 Query: 2413 LLQSLEAVAQAEVVVHSEPAQPGPDGEEVAPQIIAYLV--PMGGQTLDVADLRQQLATRL 2470 L V +A V+ DG+ Q++ Y+V GG + L LAT L Sbjct: 925 RLLEHPWVREAAVL--------AVDGK----QLVGYVVLESEGGDWREA--LAAHLATSL 970 Query: 2471 PDYMMPTALVPLHVMPLTPNGKLDRQALPRPD-STATSVYEAARGPLEETLAGLWAELLG 2529 P+YM+P + L MPL+PNGKLDR+ALP P+ S A + Y A R +E TLA +W +LLG Sbjct: 971 PEYMVPAQWLALERMPLSPNGKLDRKALPAPEVSVAQAGYSAPRNAVERTLAEIWQDLLG 1030 Query: 2530 LPQVGRNDDFFALGGDSILVLKLVARARKRDVKLAPKMLFEGKTPAGVAQLLTAG----- 2584 + QVG +D+FF+LGGDSI+ +++V+RAR+ ++L+P+ LF+ + +A AG Sbjct: 1031 VEQVGLDDNFFSLGGDSIVSIQVVSRARQAGLQLSPRDLFQHQNIRSLALAAKAGAATAE 1090 Query: 2585 SGAAGGVERIMPLPPAQRNGLLPASYAQARQWFLWQLDPGSSAYHINGALRLCGTLDEAA 2644 G A G + L P QR WF Q P ++ + L+ LD Sbjct: 1091 QGPASGE---VALAPVQR-------------WFFEQSIPNRQHWNQSLLLQARQPLDGDR 1134 Query: 2645 LEQAFSRLLERHPSLRTVLRADADGQVLQWVQPHACLAFKRIDLEPLAEGPRQARLHAEV 2704 L +A RL +H +LR R + W Q +A A EPL RQA + Sbjct: 1135 LGRALERLQAQHDALRLRFREERGA----WHQAYAEQAG-----EPLWR--RQAGSEEVL 1183 Query: 2705 ASLCRQ---PFDLEAGPLLRIGLLRESGHRHVLVMVMHHIISDGWSMQLIMDEFASLYGA 2761 +LC + DLE GPLLR L+ + L++V+HH+ DG S ++++++ LY Sbjct: 1184 LALCEEAQRSLDLEQGPLLRALLVDMADGSQRLLLVIHHLAVDGVSWRILLEDLQRLY-- 1241 Query: 2762 CCQGREAGLPA-LPLQYADYAAWQRQWM-QGGQRETQLRYWQDHLGQSQPSLLLPADHP 2818 A L A L + + Y AW R Q G R +L YWQ L + + LP ++P Sbjct: 1242 ------ADLDADLGPRSSSYQAWSRHLHEQAGARLDELDYWQAQLHDAPHA--LPCENP 1292 >PA2402_3 [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins Pae Pseudomonas aeruginosa Length = 1495 Score = 1332 bits (3448), Expect = 0.0, Method: Compositional matrix adjust. Identities = 741/1511 (49%), Positives = 981/1511 (64%), Gaps = 38/1511 (2%) Query: 53 PLSFAQQRLWYLWKLTPQSSAYHLAGGLRLQGPLEAAALERAVDALALHHPALRTVLRED 112 PLS AQQR+W+LWKL P+S+AYHL L ++G L+ AAL++A D L L H LRT E+ Sbjct: 5 PLSHAQQRMWFLWKLEPESAAYHLPSVLHVRGVLDQAALQQAFDWLVLRHETLRTRF-EE 63 Query: 113 ADGNVTQTVLPACAWSLSRQDLSLLPAHRRQDALREQVQRLCSRPFELDGGALVRACLLQ 172 DG QT+L + +D A + LR++V +PF+L G L+R LL Sbjct: 64 VDGQARQTILANMPLRIVLEDC----AGASEATLRQRVAEEIRQPFDLARGPLLRVRLLA 119 Query: 173 VDEQEHQLIVVMHHIISDAQSTQLILAELLALYQAARQGQAISAAWHGPDLGDYAVWQRQ 232 + QEH L++ HHI+SD S Q+++ ELL Y AAR+G+ + A DYA W R Sbjct: 120 LAGQEHVLVITQHHIVSDGWSMQVMVDELLQAYAAARRGEQPTLAPLTLQYADYAAWHRA 179 Query: 233 CLNSTQAERQLAWWKAQLGNSSPVLELPTDHARRPDGQYGAASWRIVLEPALLDALRRRA 292 L+S + RQL +W+ +LG PVLELP D R + L +L + L A Sbjct: 180 WLDSGEGARQLDYWRERLGAEQPVLELPADRVRPAQASGRGQRLDMALPVSLSEELLACA 239 Query: 293 QGQGCSLFVVLLCAFQALLYRHTSQRDVRVGVPVSHRLRSELAAAVGFFVDTQVLRAELA 352 + +G + F++LL +FQ LL R++ Q D+RVGVP+++R R+E+ +GFFV+TQVLR ++ Sbjct: 240 RREGVTPFMLLLASFQVLLKRYSGQSDIRVGVPIANRNRAEVERLIGFFVNTQVLRCQVD 299 Query: 353 GQTTLESLLAQVRDTSFAAQAHRDIPLERLVEVLQPERSIGRTPLFQVMFNHLREQADGS 412 LL +VR+ + AQAH+D+P E+LV+ LQPER++ +PLFQVM+NH + + Sbjct: 300 AGLAFRDLLGRVREAALGAQAHQDLPFEQLVDALQPERNLSHSPLFQVMYNHQSGERQDA 359 Query: 413 QSWPGLSVQRLDFDAAVAQFELTLETSEEANGELSATFRYARELFDESSIARMAQHYVAI 472 Q GL ++ +D A AQF+L L+T E +G L A YA +LF+ ++ RMA+H+ + Sbjct: 360 QV-DGLHIESFAWDGAAAQFDLALDTWETPDG-LGAALTYATDLFEARTVERMARHWQNL 417 Query: 473 LQALATQPQLRVAELQLRGAEEDRQL-HSWGVNNEQHAEVMEPVHEQIARQARRQPEATA 531 L+ + PQ V L + AEE QL W ++ + VH Q R P A A Sbjct: 418 LRGMLENPQASVDSLPMLDAEERGQLLEGWNATAAEYP-LQRGVHRLFEEQVERTPTAPA 476 Query: 532 LLFGRQQLSYGALERRANQLAHRLIRLGAGPEVKVGIAVERSLEMVIGLLGILKAGAAYV 591 L FG ++L Y L RRAN+LAH LI G G + VG+A+ERS+EMV+ L+ ILKAG AYV Sbjct: 477 LAFGEERLDYAELNRRANRLAHALIERGVGADRLVGVAMERSIEMVVALMAILKAGGAYV 536 Query: 592 PLDPEYPAQRLQYMMQDSGMRLLLTQQHVLPTLPPLAGLPVLALDQLD--LDDEAHQPPA 649 P+DPEYP +R YM++DSG++LLL+Q H+ LP G+ + LDQ D L++ A P Sbjct: 537 PVDPEYPEERQAYMLEDSGVQLLLSQSHL--KLPLAQGVQRIDLDQADAWLENHAENNPG 594 Query: 650 VRVHGENLAYVIYTSGSTGQPKGVANRHCALRNRLAWMQQAYRLEPHDTVLQKTPFSFDV 709 + ++GENLAYVIYTSGSTG+PKG NRH AL NRL WMQQAY L DTVLQKTPFSFDV Sbjct: 595 IELNGENLAYVIYTSGSTGKPKGAGNRHSALSNRLCWMQQAYGLGVGDTVLQKTPFSFDV 654 Query: 710 SVWEFFWPLMIGARLALAQPGDHRDPARLVEQIQRHAVSTLHFVPSMLQAFLAHDEIEGC 769 SVWEFFWPLM GARL +A PGDHRDPA+LV I R V TLHFVPSMLQAFL +++ C Sbjct: 655 SVWEFFWPLMSGARLVVAAPGDHRDPAKLVALINREGVDTLHFVPSMLQAFLQDEDVVSC 714 Query: 770 SSLHRLICSGEALPVEAQQGVFARLPQVALYNLYGPTEAAIDVTHWTCRADGRSQVPIGR 829 +SL R++CSGEAL +AQQ VFA+LPQ LYNLYGPTEAAIDVTHW+C +G+ VPIGR Sbjct: 715 TSLKRIVCSGEALSADAQQQVFAKLPQAGLYNLYGPTEAAIDVTHWSCVEEGKDAVPIGR 774 Query: 830 PISSIRTLVLDGDLNLAPQGVPGELYLGGIGLARGYLGRAGLSAERFVADPFSADGERLY 889 PI+++ +LDGDL P GV GELYL G GLARGY R GL+AERFVA PF A GER+Y Sbjct: 775 PIANLGCYILDGDLEPVPVGVLGELYLAGRGLARGYHQRPGLTAERFVASPFVA-GERMY 833 Query: 890 RTGDLVRWNREGQLDYLGRLDHQVKIRGLRIELGEIEARLLAQPGVREAVVVARESAGTS 949 RTGDL R+ +G ++Y GR+DHQVK+RGLRIELGEIEARLL P VREA V+A +S Sbjct: 834 RTGDLARYRADGVIEYAGRIDHQVKLRGLRIELGEIEARLLEHPWVREAAVLAVDS---R 890 Query: 950 RLVAYV----SGTDLVAATLRSALTKDLPDYMVPALIEVLEHLPLNANGKVDRRALPDPA 1005 +LV YV G D A L + L LP+YMVPA LE +PL+ NGK+DR+ALP P Sbjct: 891 QLVGYVVLESEGGDWREA-LAAHLATSLPEYMVPAQWLALERMPLSPNGKLDRKALPRPQ 949 Query: 1006 QPLQRAYEAPRGQAEQVLAAVWAEVLGLQQVGRHDNFFELGGDSILSLQIVAGLRRRGSQ 1065 + + AP+ + E+ +AAVWA+VL L++VG DNFF LGGDSI+S+Q+V+ R G Q Sbjct: 950 AAAGQTHVAPQNEMERRIAAVWADVLKLEEVGATDNFFALGGDSIVSIQVVSRCRAAGIQ 1009 Query: 1066 LAPRLIFERQTIAQLAPAIAHSTAPQLHAQVSVQGELPLLPIQAEFFAMDIPVRHHWNQS 1125 P+ +F++QT+ LA A Q+ Q V GE LLP Q FF IP R HWNQS Sbjct: 1010 FTPKDLFQQQTVQGLARVARVGAAVQME-QGPVSGETVLLPFQRLFFEQPIPNRQHWNQS 1068 Query: 1126 ILLATDAPLDMAALNTALQAVVAHHDSLRLRYTRDDQGQWRQTYGQHDPAQL-RELLWVR 1184 +LL L+ AL ALQA+V HHD+LRLR+ D G W + +H A L LLW Sbjct: 1069 LLLKPREALNAKALEAALQALVEHHDALRLRFHETD-GTW---HAEHAEATLGGALLWRA 1124 Query: 1185 QGLPGNAIAPLCEQAQRSLNLARGPLLRAVAMELEEGGWRLLLVIHHLVVDGVSWRILLA 1244 + + A+ LCE++QRSL+LA GPLLR++ +++ +GG RLLLVIHHLVVDGVSWRILL Sbjct: 1125 EAVDRQALESLCEESQRSLDLADGPLLRSLLVDMADGGQRLLLVIHHLVVDGVSWRILLE 1184 Query: 1245 DLQQAYRQCVALEPLVLPARTASYQQWAHVL--QGRHGALLPQRPYWQAQMQ-PPSVLPC 1301 DLQ+AY+Q + E LP +T+ ++ WA + R ++ Q +W+ ++ P+ LPC Sbjct: 1185 DLQRAYQQSLRGEAPRLPGKTSPFKAWAGRVSEHARGESMKAQLQFWRELLEGAPAELPC 1244 Query: 1302 DDAGGEATMRQRQEMSFGLDKERTNALLRRVPAAYRTRINDVLLTALVRALCGWSGLSEI 1361 + G R + D+ T LL++ PAAYRT++ND+LLTAL R +C WSG S Sbjct: 1245 EHPQGALEQRFATSVQSRFDRSLTERLLKQAPAAYRTQVNDLLLTALARVVCRWSGASSS 1304 Query: 1362 QVDIEGHGREDGTGQLDLSRTVGWFTSVFPLRLSGAGTPQQALKRIKESLRAVPEAGLGF 1421 V +EGHGRE+ +DLSRTVGWFTS+FP+RLS ++LK IKE LRA+P+ GLG+ Sbjct: 1305 LVQLEGHGREELFADIDLSRTVGWFTSLFPVRLSPVADLGESLKAIKEQLRAIPDKGLGY 1364 Query: 1422 GLLR------QAGNLPGSSSSPVIFNYLGQFDASFDGTSGWRPAQEESGAAIDPDAPMQH 1475 GLLR A L G + + FNYLGQFDA FD + PA E +GA +DP AP+ + Sbjct: 1365 GLLRYLAGEESARVLAGLPQARITFNYLGQFDAQFDEMALLDPAGESAGAEMDPGAPLDN 1424 Query: 1476 EFAVEGQVYDGQLLINVAYSGKRYARASVQAWVERFEQELDALITHCT-SGACGATPSDF 1534 ++ G+V+DG+L I+ ++S + + V+ + + EL AL+ C S GATPSDF Sbjct: 1425 WLSLNGRVFDGELSIDWSFSSQMFGEDQVRRLADDYVAELTALVDFCCDSPRHGATPSDF 1484 Query: 1535 PLAGLDQTAID 1545 PLAGLDQ +D Sbjct: 1485 PLAGLDQARLD 1495 Score = 751 bits (1939), Expect = 0.0, Method: Compositional matrix adjust. Identities = 456/1028 (44%), Positives = 611/1028 (59%), Gaps = 35/1028 (3%) Query: 2606 LPASYAQARQWFLWQLDPGSSAYHINGALRLCGTLDEAALEQAFSRLLERHPSLRTVLRA 2665 LP S+AQ R WFLW+L+P S+AYH+ L + G LD+AAL+QAF L+ RH +LRT Sbjct: 4 LPLSHAQQRMWFLWKLEPESAAYHLPSVLHVRGVLDQAALQQAFDWLVLRHETLRTRFE- 62 Query: 2666 DADGQVLQWVQPHACLAFKRIDLEPLAEGPRQARLHAEVASLCRQPFDLEAGPLLRIGLL 2725 + DGQ Q + + L RI LE A G +A L VA RQPFDL GPLLR+ LL Sbjct: 63 EVDGQARQTILANMPL---RIVLEDCA-GASEATLRQRVAEEIRQPFDLARGPLLRVRLL 118 Query: 2726 RESGHRHVLVMVMHHIISDGWSMQLIMDEFASLYGACCQGREAGLPALPLQYADYAAWQR 2785 +G HVLV+ HHI+SDGWSMQ+++DE Y A +G + L L LQYADYAAW R Sbjct: 119 ALAGQEHVLVITQHHIVSDGWSMQVMVDELLQAYAAARRGEQPTLAPLTLQYADYAAWHR 178 Query: 2786 QWMQGGQRETQLRYWQDHLGQSQPSLLLPADHPRRPDGLYRAARHEAVLPPPLVAALRQR 2845 W+ G+ QL YW++ LG QP L LPAD R R R + LP L L Sbjct: 179 AWLDSGEGARQLDYWRERLGAEQPVLELPADRVRPAQASGRGQRLDMALPVSLSEELLAC 238 Query: 2846 VQSDGGTLFAVLLAAAQLLMYRYSGQNDIRLGVPIANRHLPDTEGVVGFFVNTQVLRAEI 2905 + +G T F +LLA+ Q+L+ RYSGQ+DIR+GVPIANR+ + E ++GFFVNTQVLR ++ Sbjct: 239 ARREGVTPFMLLLASFQVLLKRYSGQSDIRVGVPIANRNRAEVERLIGFFVNTQVLRCQV 298 Query: 2906 DPRQSLARLVQLTRETAQGAQQHQDLPFEQLVEVLQPQRLVGVNPLFQVMFNHQRHARPT 2965 D + L+ RE A GAQ HQDLPFEQLV+ LQP+R + +PLFQVM+NHQ R Sbjct: 299 DAGLAFRDLLGRVREAALGAQAHQDLPFEQLVDALQPERNLSHSPLFQVMYNHQSGERQD 358 Query: 2966 SHQLPQLTLEPFELEEQDAQFELAIDTLEDTDGGLSVSLTYARELFEPQTMATMASHYLV 3025 + Q+ L +E F + AQF+LA+DT E D GL +LTYA +LFE +T+ MA H+ Sbjct: 359 A-QVDGLHIESFAWDGAAAQFDLALDTWETPD-GLGAALTYATDLFEARTVERMARHWQN 416 Query: 3026 ALEALASQPQCRVGEIDWLGPAERSR-LAAWGDKVSPYATPAVITTRIAQRASIQPDAVA 3084 L + PQ V + L ER + L W + Y + ++ P A A Sbjct: 417 LLRGMLENPQASVDSLPMLDAEERGQLLEGWNATAAEYPLQRGVHRLFEEQVERTPTAPA 476 Query: 3085 LISGNRSMSYGQLNTRVNQLAHYLLQRGLQPEARVGVALERSADMVVAVLAILKAGATYV 3144 L G + Y +LN R N+LAH L++RG+ + VGVA+ERS +MVVA++AILKAG YV Sbjct: 477 LAFGEERLDYAELNRRANRLAHALIERGVGADRLVGVAMERSIEMVVALMAILKAGGAYV 536 Query: 3145 PLDPDYPVQRLAAIIEDSALSLLLSQTSVSQRLPGGRAEQTLYLDQLD--LQAQPHDEPD 3202 P+DP+YP +R A ++EDS + LLLSQ+ + +LP + Q + LDQ D L+ + P Sbjct: 537 PVDPEYPEERQAYMLEDSGVQLLLSQSHL--KLPLAQGVQRIDLDQADAWLENHAENNPG 594 Query: 3203 VTIHSDSLAYVIYTSGSTGRPKGVGISHRCLMEHGQIAADFFGLTPQDCMLQFSTLNFDG 3262 + ++ ++LAYVIYTSGSTG+PKG G H L +GL D +LQ + +FD Sbjct: 595 IELNGENLAYVIYTSGSTGKPKGAGNRHSALSNRLCWMQQAYGLGVGDTVLQKTPFSFDV 654 Query: 3263 CIEQLFPPLLVGAAVVLRGP-ELWDSQRLHVELLAHRISVLDLTTAYWLLLVQDFARMGV 3321 + + F PL+ GA +V+ P + D +L + + L + +QD V Sbjct: 655 SVWEFFWPLMSGARLVVAAPGDHRDPAKLVALINREGVDTLHFVPSMLQAFLQD---EDV 711 Query: 3322 PDYGVLRRVHVGGEAMPPEGIKAWRDAGLAQVELFNTYGPTEATVTASILSCAPYVSGQT 3381 L+R+ GEA+ + + A L Q L+N YGPTEA + + SC G+ Sbjct: 712 VSCTSLKRIVCSGEALSADAQQQ-VFAKLPQAGLYNLYGPTEAAIDVTHWSCVE--EGKD 768 Query: 3382 VLPAQMPIGAPLAGRKLRVLDAELSPLPIGVAGELCIGGELLARGYLNQPGLSAERFVAD 3441 +PIG P+A +LD +L P+P+GV GEL + G LARGY +PGL+AERFVA Sbjct: 769 A----VPIGRPIANLGCYILDGDLEPVPVGVLGELYLAGRGLARGYHQRPGLTAERFVAS 824 Query: 3442 PLGDGGARLYRTGDLVRWTHAGQLEYLGRIDHQVKIRGFRIEMGEIESIMLAQPEVREAV 3501 P G R+YRTGDL R+ G +EY GRIDHQVK+RG RIE+GEIE+ +L P VREA Sbjct: 825 PFV-AGERMYRTGDLARYRADGVIEYAGRIDHQVKLRGLRIELGEIEARLLEHPWVREAA 883 Query: 3502 VVAREGVGSLQLVAYVTPQHGRHIETAELRECLVRH----LPDYMVPAALVVLPALPLNA 3557 V+A V S QLV YV + E + RE L H LP+YMVPA + L +PL+ Sbjct: 884 VLA---VDSRQLVGYVVLES----EGGDWREALAAHLATSLPEYMVPAQWLALERMPLSP 936 Query: 3558 NGKVDRKALPEPVYESRTGHEPPQGECEQALAAIWAEVLGLPAVGRHDNFFELGGHSLSI 3617 NGK+DRKALP P + H PQ E E+ +AA+WA+VL L VG DNFF LGG S+ Sbjct: 937 NGKLDRKALPRPQAAAGQTHVAPQNEMERRIAAVWADVLKLEEVGATDNFFALGGDSIVS 996 Query: 3618 LRIQSRIQ 3625 +++ SR + Sbjct: 997 IQVVSRCR 1004 Score = 461 bits (1187), Expect = e-128, Method: Compositional matrix adjust. Identities = 415/1313 (31%), Positives = 624/1313 (47%), Gaps = 112/1313 (8%) Query: 1554 VADLYPLSPMQSGMLFHSVSEPDNAAYTMQMQVALEA-LQPERFRAAWQAVLDRHAILRS 1612 VA+L PLS Q M F EP++AAY + + + L + A+ ++ RH LR+ Sbjct: 1 VAEL-PLSHAQQRMWFLWKLEPESAAYHLPSVLHVRGVLDQAALQQAFDWLVLRHETLRT 59 Query: 1613 AILQRDDAPLQWVARRVVLPWQLRDCRHSPDLAAELDELARREREAGFDLARPPLMRLML 1672 + D Q + + L L DC + + A L + E FDLAR PL+R+ L Sbjct: 60 RFEEVDGQARQTILANMPLRIVLEDCAGASE--ATLRQRVAEEIRQPFDLARGPLLRVRL 117 Query: 1673 VSTGEQGYHLIWTVHHLLLDGWSTSQLLGEVLRHYAGQ------TLDEPVAAYGDYIRW- 1725 ++ Q + L+ T HH++ DGWS ++ E+L+ YA TL Y DY W Sbjct: 118 LALAGQEHVLVITQHHIVSDGWSMQVMVDELLQAYAAARRGEQPTLAPLTLQYADYAAWH 177 Query: 1726 ---LQGRDQQASRHHWQSLLHRLQEPSLLVA-RLPPAKQPNRARDYRQYTCCLGQAQTRR 1781 L + +W+ L Q L A R+ PA+ R + + L + + Sbjct: 178 RAWLDSGEGARQLDYWRERLGAEQPVLELPADRVRPAQASGRGQ---RLDMALPVSLSEE 234 Query: 1782 LVEFARARHLTLSTLVQAAWALLLQRYAGHGTVCFGATTAGRPMDLAGAESMLGLFINTL 1841 L+ AR +T L+ A++ +LL+RY+G + G A R + A E ++G F+NT Sbjct: 235 LLACARREGVTPFMLLLASFQVLLKRYSGQSDIRVGVPIANR--NRAEVERLIGFFVNTQ 292 Query: 1842 PVVTTLTPQTALDEWLQQLQRQSAQSREHEYTPLYEI------QRLAGHSGQSLFDTVVV 1895 + + A + L +++ + ++ H+ P ++ +R HS LF + Sbjct: 293 VLRCQVDAGLAFRDLLGRVREAALGAQAHQDLPFEQLVDALQPERNLSHS--PLFQVMYN 350 Query: 1896 FENYPVDAALHSQEVDKLVVGEVRFS-SGNHYPLTLRV-SLAEQLQIDFLHDTGMIAPEL 1953 ++ +VD L + + + + L L + L + T + Sbjct: 351 HQS----GERQDAQVDGLHIESFAWDGAAAQFDLALDTWETPDGLGAALTYATDLFEART 406 Query: 1954 LARMAAQFTSLLE------QFSQD-----DGETRRRRLADLSLTDLPAPLQGPTIRADDV 2002 + RMA + +LL Q S D D E R + L + T PLQ R Sbjct: 407 VERMARHWQNLLRGMLENPQASVDSLPMLDAEERGQLLEGWNATAAEYPLQRGVHRL--- 463 Query: 2003 IERWAAQVSQQPGAAALTDGNHALDMAGLCAWVEQMAQQMRQRGIGCEDRVAIHAERSCA 2062 + QV + P A AL G LD A L ++A + +RG+G + V + ERS Sbjct: 464 ---FEEQVERTPTAPALAFGEERLDYAELNRRANRLAHALIERGVGADRLVGVAMERSIE 520 Query: 2063 FVVAVLATLRVGAAYVPLDPALPAERLHYQLQDSAAVLLLSATAPDWAASVPVLPLA-SL 2121 VVA++A L+ G AYVP+DP P ER Y L+DS LLLS + LPLA + Sbjct: 521 MVVALMAILKAGGAYVPVDPEYPEERQAYMLEDSGVQLLLSQSHLK-------LPLAQGV 573 Query: 2122 HGVPKRVPYCWPAVH----PG------QAAYVIYTSGSTGRPKGVVVSRGALANYVAGVL 2171 + W H PG AYVIYTSGSTG+PKG AL+N + + Sbjct: 574 QRIDLDQADAWLENHAENNPGIELNGENLAYVIYTSGSTGKPKGAGNRHSALSNRLCWMQ 633 Query: 2172 ERLDLREQDRSMAMVSTVGADLGHTVLFGALCSGRLLHLIPPQCSFDPDAMASYMEQHQV 2231 + L D ++ + D+ F L SG L + P DP + + + + V Sbjct: 634 QAYGLGVGD-TVLQKTPFSFDVSVWEFFWPLMSGARLVVAAPGDHRDPAKLVALINREGV 692 Query: 2232 DVLKIVPSHLQALLHAASPASVLPRSRLVLGGEASRKPLLAHIASLRPQCRVMNHYGPTE 2291 D L VPS LQA L S R+V GEA + + PQ + N YGPTE Sbjct: 693 DTLHFVPSMLQAFLQDEDVVSCTSLKRIVCSGEALSADAQQQVFAKLPQAGLYNLYGPTE 752 Query: 2292 TTVGVLTQEASSALDEADSLPIGQPIAQARAYVLDAELQPVPQGVAGELYLAGHGVARAY 2351 + V S + D++PIG+PIA Y+LD +L+PVP GV GELYLAG G+AR Y Sbjct: 753 AAIDV--THWSCVEEGKDAVPIGRPIANLGCYILDGDLEPVPVGVLGELYLAGRGLARGY 810 Query: 2352 QQRPAQSAERFVADLLEPGQRMYRSGDRVRQLADGSLEFLGRLDGQIKVRGYRVELREIA 2411 QRP +AERFVA G+RMYR+GD R ADG +E+ GR+D Q+K+RG R+EL EI Sbjct: 811 HQRPGLTAERFVASPFVAGERMYRTGDLARYRADGVIEYAGRIDHQVKLRGLRIELGEIE 870 Query: 2412 ALLQSLEAVAQAEVVVHSEPAQPGPDGEEVAPQIIAYLV--PMGGQTLDVADLRQQLATR 2469 A L V +A V+ + Q++ Y+V GG + L LAT Sbjct: 871 ARLLEHPWVREAAVLAVD------------SRQLVGYVVLESEGGDWREA--LAAHLATS 916 Query: 2470 LPDYMMPTALVPLHVMPLTPNGKLDRQALPRPDSTATSVYEAARGPLEETLAGLWAELLG 2529 LP+YM+P + L MPL+PNGKLDR+ALPRP + A + A + +E +A +WA++L Sbjct: 917 LPEYMVPAQWLALERMPLSPNGKLDRKALPRPQAAAGQTHVAPQNEMERRIAAVWADVLK 976 Query: 2530 LPQVGRNDDFFALGGDSILVLKLVARARKRDVKLAPKMLFEGKTPAGVAQLLTAGSGAAG 2589 L +VG D+FFALGGDSI+ +++V+R R ++ PK LF+ +T G+A++ A GAA Sbjct: 977 LEEVGATDNFFALGGDSIVSIQVVSRCRAAGIQFTPKDLFQQQTVQGLARV--ARVGAAV 1034 Query: 2590 GVERIMPLPPAQRNGLLPASYAQARQWFLWQLDPGSSAYHINGALRLCGTLDEAALEQAF 2649 +E+ P + LLP ++ F Q P ++ + L+ L+ ALE A Sbjct: 1035 QMEQG---PVSGETVLLP-----FQRLFFEQPIPNRQHWNQSLLLKPREALNAKALEAAL 1086 Query: 2650 SRLLERHPSLRTVLRADADGQVLQWVQPHACLAFKRIDLEPLAEGPRQARLHAEVASLCR 2709 L+E H +LR + DG W HA L RQA + SLC Sbjct: 1087 QALVEHHDALRLRFH-ETDG---TWHAEHAEATLGGALLWRAEAVDRQA-----LESLCE 1137 Query: 2710 Q---PFDLEAGPLLRIGLLRESGHRHVLVMVMHHIISDGWSMQLIMDEFASLYGACCQGR 2766 + DL GPLLR L+ + L++V+HH++ DG S ++++++ Y +G Sbjct: 1138 ESQRSLDLADGPLLRSLLVDMADGGQRLLLVIHHLVVDGVSWRILLEDLQRAYQQSLRGE 1197 Query: 2767 EAGLPALPLQYADYAAWQRQWMQGGQRETQLRYWQDHLGQSQPSLLLPADHPR 2819 LP + +A + +G + QL++W++ L + P+ LP +HP+ Sbjct: 1198 APRLPGKTSPFKAWAGRVSEHARGESMKAQLQFWRELL-EGAPA-ELPCEHPQ 1248 >PA2424_3 [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins Pae Pseudomonas aeruginosa Length = 1520 Score = 1123 bits (2905), Expect = 0.0, Method: Compositional matrix adjust. Identities = 683/1528 (44%), Positives = 913/1528 (59%), Gaps = 46/1528 (3%) Query: 51 PAPLSFAQQRLWYLWKLTPQSSAYHLAGGLRLQGPLEAAALERAVDALALHHPALRTVLR 110 P PLS++QQR+W+LW+L P S AY++ G RL GPL+ A E A+ AL H LRT Sbjct: 8 PVPLSYSQQRMWFLWQLEPDSPAYNVGGLARLSGPLDVARFEAALQALVQRHETLRTTF- 66 Query: 111 EDADGNVTQTVLPACAWSLSRQDLSLLPAHRRQDALREQVQRLCSRPFELDGGALVRACL 170 DG Q V + QD S L RQ L+ RPF+L+ G L+R C+ Sbjct: 67 PSVDGVPVQRVHGDGGLHMDWQDFSALDRDSRQQHLQTLADSEAHRPFDLESGPLLRVCM 126 Query: 171 LQVDEQEHQLIVVMHHIISDAQSTQLILAELLALYQAARQGQAISAAWHGPDLGDYAVWQ 230 +++ E+EH L+V +HHI+++ + + EL ALY+A + DY+VWQ Sbjct: 127 VKMAEREHYLVVTLHHIVTEGWAMDIFARELGALYEAFLDDRESPLEPLPVQYLDYSVWQ 186 Query: 231 RQCLNSTQAERQLAWWKAQLGNSSPVLELPTDHARRPDGQYGAASWRIVLEPALLDALRR 290 R+ L S + +RQL +WKAQLGN P+LELP D R P + +R L P L + +RR Sbjct: 187 REWLESGERQRQLDYWKAQLGNEHPLLELPGDRPRPPVQSHQGDLYRFDLSPELAERVRR 246 Query: 291 RAQGQGCSLFVVLLCAFQALLYRHTSQRDVRVGVPVSHRLRSELAAAVGFFVDTQVLRAE 350 +G ++F+ + ALLYR++ Q+D+R+G PV++R+R E +G F++TQVLR Sbjct: 247 FNAARGLTMFMTMTATLAALLYRYSGQQDLRIGAPVANRIRPESEGLIGAFLNTQVLRCR 306 Query: 351 LAGQTTLESLLAQVRDTSFAAQAHRDIPLERLVEVLQPERSIGRTPLFQVMFNHLREQAD 410 L GQ ++ LL QVR T Q+H+D+P + LVE LQP RS PLFQVM N R + Sbjct: 307 LDGQMSVGELLEQVRQTVIDGQSHQDLPFDHLVEALQPPRSAAYNPLFQVMCNVQRWEFQ 366 Query: 411 GSQSWPGLSVQRLDFDAAVAQFELTLETSEEANGELSATFRYARELFDESSIARMAQHYV 470 ++ G++V+ + DA +F+L LE + + + L Y+R+LFDE IARMA H+ Sbjct: 367 QTRQLAGMTVEYIANDARATKFDLNLEVT-DLDQRLGCCLTYSRDLFDEPRIARMAGHWQ 425 Query: 471 AILQALATQPQLRVAELQLRGAEEDRQLHSWGVNNEQHAEVMEPVHEQIARQARRQPEAT 530 +L+AL PQ R+AEL L AEE +QL G E A + + +H A + P+A Sbjct: 426 NLLEALLGDPQRRIAELPLFAAEERKQLLLAGTAGE--AGLQDTLHGLFAARVAASPQAP 483 Query: 531 ALLFGRQQLSYGALERRANQLAHRLIRLGAGPEVKVGIAVERSLEMVIGLLGILKAGAAY 590 AL F Q LSY L+ R+N+LA L G GPEV+VG+A+ERSLEMV+GLL ILKAG AY Sbjct: 484 ALTFAGQTLSYAELDARSNRLARVLRSHGVGPEVRVGLALERSLEMVVGLLAILKAGGAY 543 Query: 591 VPLDPEYPAQRLQYMMQDSGMRLLLTQQHVLPTLPPL-AGLPVLALDQ----LDLDDEAH 645 VPLDPEYP +RLQYM++DSG+RLLL+ + L L AG+ L++ LD +D A Sbjct: 544 VPLDPEYPLERLQYMIEDSGVRLLLSHAALFEALGELPAGVARWCLEEDGPALDAEDPA- 602 Query: 646 QPPAVRVHGENLAYVIYTSGSTGQPKGVANRHCALRNRLAWMQQAYRLEPHDTVLQKTPF 705 P A ++ AY+IYTSGSTG+PKGVA H + A + + + + D L Sbjct: 603 -PLAALSGPQHQAYLIYTSGSTGKPKGVAVSHGEIAMHCAAVIECFGMRAEDCELHFYSI 661 Query: 706 SFDVSVWEFFWPLMIGARLALAQPGDHRDPARLVEQIQRHAVSTLHFVPSMLQAFLAHDE 765 +FD + PL+ GAR+ L G + E I+ VS L F PS E Sbjct: 662 NFDAASERLLAPLLCGARVVLRAQG-QWGAEEICELIRAEGVSILGFTPSYGSQLAQWLE 720 Query: 766 IEGCSSLHRL-ICSGEALPVEAQQGVFARLPQVALYNLYGPTEAAIDVTHWTCRA----- 819 +G R+ I GEAL E Q + + +N YGPTE V C A Sbjct: 721 SQGRQLPVRMCITGGEALTGEHLQRIRQAFAPASFFNAYGPTETV--VMPLACLAPERLE 778 Query: 820 DGRSQVPIGRPISSIRTLVLDGDLNLAPQGVPGELYLGGIGLARGYLGRAGLSAERFVAD 879 +G + VPIG + + +LD DL L PQG GELY+GG GLARGY R LSAERFV D Sbjct: 779 EGAASVPIGSVVGARVAYILDADLALVPQGATGELYVGGAGLARGYHERPALSAERFVPD 838 Query: 880 PFSADGERLYRTGDLVRWNREGQLDYLGRLDHQVKIRGLRIELGEIEARLLAQPGVREAV 939 PF+A+G RLYRTGDLVR GQ++Y+GR+DHQVKIRG RIELGEIEARLL P VREA+ Sbjct: 839 PFAAEGGRLYRTGDLVRLCDNGQVEYVGRIDHQVKIRGFRIELGEIEARLLEHPQVREAL 898 Query: 940 VVARESAGTSRLVAYVSGT------DLVAA---TLRSALTKDLPDYMVPALIEVLEHLPL 990 V+A +S +L YV+ D AA L++ L + LPDYMVPA + +L LPL Sbjct: 899 VLALDSPSGKQLAGYVASAVAEQDEDAQAALREALKTHLKQQLPDYMVPAHLLLLASLPL 958 Query: 991 NANGKVDRRALPDPAQPLQR-AYEAPRGQAEQVLAAVWAEVLGLQQVGRHDNFFELGGDS 1049 ANGK+DRRALP P L R AYEAPR EQ LA VW EVL +++VG DNFFELGGDS Sbjct: 959 TANGKLDRRALPAPDPALNRQAYEAPRSVLEQQLAGVWREVLNVERVGLGDNFFELGGDS 1018 Query: 1050 ILSLQIVAGLRRRGSQLAPRLIFERQTIAQLAPAIAHSTAPQLHAQVSVQGELPLLPIQA 1109 ILS+Q+V+ R+ G +PR +F+ QT+ LA HS A Q Q VQG+ L PIQ Sbjct: 1019 ILSIQVVSRARQLGIHFSPRDLFQHQTVQSLAAVARHSQASQAE-QGPVQGDSALTPIQH 1077 Query: 1110 EFFAMDIPVRHHWNQSILLATDAPLDMAALNTALQAVVAHHDSLRLRYTRDDQGQWRQTY 1169 FF + + R HWNQ++LL +D+ L +LQ +V HD+LRL + + D G+W Sbjct: 1078 WFFDLPLARREHWNQALLLQPRQAIDLGLLRKSLQRLVEQHDALRLAFRQVD-GEW---L 1133 Query: 1170 GQHDPAQLRELLWVRQGLPGNAIAPLCEQAQRSLNLARGPLLRAVAMELEEGGWRLLLVI 1229 QH P + +ELLW + A L +AQRSL+L +GPLLRAV ++ G RLLL I Sbjct: 1134 AQHRPLREQELLWHVPVQSFDECAELFAKAQRSLDLEQGPLLRAVLVDGPAGEQRLLLAI 1193 Query: 1230 HHLVVDGVSWRILLADLQQAYRQCVALEPLVLPARTASYQQWAHVLQGRHG--ALLPQRP 1287 HHLVVDGVSWR+LL DLQQ YRQ LPA+T++++ WA LQ G +L + Sbjct: 1194 HHLVVDGVSWRVLLEDLQQVYRQFAEGAEPALPAKTSAFRDWAGRLQAYAGSESLREELG 1253 Query: 1288 YWQAQM-QPPSVLPCDDAGGEATMRQRQEMSFGLDKERTNALLRRVPAAYRTRINDVLLT 1346 +WQA++ P PCD G+ + +S LD +RT LL++ PAAYRT++ND+LLT Sbjct: 1254 WWQARLGGQPVEWPCDRPQGDNREALAESVSLRLDPQRTRQLLQQAPAAYRTQVNDLLLT 1313 Query: 1347 ALVRALCGWSGLSEIQVDIEGHGREDGTGQLDLSRTVGWFTSVFPLRLSGAGTPQQALKR 1406 AL R LC WSG V +EGHGRE +DL+R+VGWFTS +PLRL+ A +P +++K Sbjct: 1314 ALARVLCRWSGQPSTLVQLEGHGREALFDDIDLTRSVGWFTSAYPLRLTPAQSPGESIKA 1373 Query: 1407 IKESLRAVPEAGLGFGLLRQAGN------LPGSSSSPVIFNYLGQFDASFDGTSGWRPAQ 1460 IKE LRAVP GLG+G+LR + + ++P+ FNYLGQFD SF + ++P Sbjct: 1374 IKEQLRAVPHKGLGYGVLRYLADPAVRQAMAALPTAPITFNYLGQFDQSF-ADALFQPLD 1432 Query: 1461 EESGAAIDPDAPMQHEFAVEGQVYDGQLLINVAYSGKRYARASVQAWVERFEQELDALIT 1520 + +G D AP+ +E +V+GQVY G+L++ YS +RY +V + + EL ALI Sbjct: 1433 QPTGPIHDEQAPLPNELSVDGQVYGGELVLRWTYSRERYDARTVNELAQAYLAELQALIE 1492 Query: 1521 HC-TSGACGATPSDFPLAGLDQTAIDQL 1547 HC GA G TPSDFPLA L Q +D L Sbjct: 1493 HCLEDGAGGLTPSDFPLAQLSQAQLDAL 1520 Score = 746 bits (1925), Expect = 0.0, Method: Compositional matrix adjust. Identities = 451/1055 (42%), Positives = 607/1055 (57%), Gaps = 25/1055 (2%) Query: 2606 LPASYAQARQWFLWQLDPGSSAYHINGALRLCGTLDEAALEQAFSRLLERHPSLRTVLRA 2665 +P SY+Q R WFLWQL+P S AY++ G RL G LD A E A L++RH +LRT Sbjct: 9 VPLSYSQQRMWFLWQLEPDSPAYNVGGLARLSGPLDVARFEAALQALVQRHETLRTTF-P 67 Query: 2666 DADGQVLQWVQPHACLAFKRIDLEPLAEGPRQARLHAEVASLCRQPFDLEAGPLLRIGLL 2725 DG +Q V L D L RQ L S +PFDLE+GPLLR+ ++ Sbjct: 68 SVDGVPVQRVHGDGGLHMDWQDFSALDRDSRQQHLQTLADSEAHRPFDLESGPLLRVCMV 127 Query: 2726 RESGHRHVLVMVMHHIISDGWSMQLIMDEFASLYGACCQGREAGLPALPLQYADYAAWQR 2785 + + H LV+ +HHI+++GW+M + E +LY A RE+ L LP+QY DY+ WQR Sbjct: 128 KMAEREHYLVVTLHHIVTEGWAMDIFARELGALYEAFLDDRESPLEPLPVQYLDYSVWQR 187 Query: 2786 QWMQGGQRETQLRYWQDHLGQSQPSLLLPADHPRRPDGLYRAARHEAVLPPPLVAALRQR 2845 +W++ G+R+ QL YW+ LG P L LP D PR P ++ + L P L +R+ Sbjct: 188 EWLESGERQRQLDYWKAQLGNEHPLLELPGDRPRPPVQSHQGDLYRFDLSPELAERVRRF 247 Query: 2846 VQSDGGTLFAVLLAAAQLLMYRYSGQNDIRLGVPIANRHLPDTEGVVGFFVNTQVLRAEI 2905 + G T+F + A L+YRYSGQ D+R+G P+ANR P++EG++G F+NTQVLR + Sbjct: 248 NAARGLTMFMTMTATLAALLYRYSGQQDLRIGAPVANRIRPESEGLIGAFLNTQVLRCRL 307 Query: 2906 DPRQSLARLVQLTRETAQGAQQHQDLPFEQLVEVLQPQRLVGVNPLFQVMFNHQRHARPT 2965 D + S+ L++ R+T Q HQDLPF+ LVE LQP R NPLFQVM N QR Sbjct: 308 DGQMSVGELLEQVRQTVIDGQSHQDLPFDHLVEALQPPRSAAYNPLFQVMCNVQRWEFQQ 367 Query: 2966 SHQLPQLTLEPFELEEQDAQFELAIDTLEDTDGGLSVSLTYARELFEPQTMATMASHYLV 3025 + QL +T+E + + +F+L ++ + D D L LTY+R+LF+ +A MA H+ Sbjct: 368 TRQLAGMTVEYIANDARATKFDLNLE-VTDLDQRLGCCLTYSRDLFDEPRIARMAGHWQN 426 Query: 3026 ALEALASQPQCRVGEIDWLGPAERSRLAAWGDKVSPYATPAVITTRIAQRASIQPDAVAL 3085 LEAL PQ R+ E+ ER +L G + A R + P A AL Sbjct: 427 LLEALLGDPQRRIAELPLFAAEERKQLLLAG-TAGEAGLQDTLHGLFAARVAASPQAPAL 485 Query: 3086 ISGNRSMSYGQLNTRVNQLAHYLLQRGLQPEARVGVALERSADMVVAVLAILKAGATYVP 3145 +++SY +L+ R N+LA L G+ PE RVG+ALERS +MVV +LAILKAG YVP Sbjct: 486 TFAGQTLSYAELDARSNRLARVLRSHGVGPEVRVGLALERSLEMVVGLLAILKAGGAYVP 545 Query: 3146 LDPDYPVQRLAAIIEDSALSLLLSQTSVSQ---RLPGGRAEQTLYLDQLDLQAQPHDEPD 3202 LDP+YP++RL +IEDS + LLLS ++ + LP G A L D L A+ Sbjct: 546 LDPEYPLERLQYMIEDSGVRLLLSHAALFEALGELPAGVARWCLEEDGPALDAEDPAPLA 605 Query: 3203 VTIHSDSLAYVIYTSGSTGRPKGVGISHRCLMEHGQIAADFFGLTPQDCMLQFSTLNFDG 3262 AY+IYTSGSTG+PKGV +SH + H + FG+ +DC L F ++NFD Sbjct: 606 ALSGPQHQAYLIYTSGSTGKPKGVAVSHGEIAMHCAAVIECFGMRAEDCELHFYSINFDA 665 Query: 3263 CIEQLFPPLLVGAAVVLRGPELWDSQRLHVELLAHRISVLDLTTAYWLLLVQDFARMG-- 3320 E+L PLL GA VVLR W ++ + + A +S+L T +Y L Q G Sbjct: 666 ASERLLAPLLCGARVVLRAQGQWGAEEICELIRAEGVSILGFTPSYGSQLAQWLESQGRQ 725 Query: 3321 VPDYGVLRRVHVGGEAMPPEGIKAWRDAGLAQVELFNTYGPTEATVTASILSCAPYVSGQ 3380 +P +R GGEA+ E ++ R A A FN YGPTE TV + AP + Sbjct: 726 LP----VRMCITGGEALTGEHLQRIRQA-FAPASFFNAYGPTE-TVVMPLACLAPERLEE 779 Query: 3381 TVLPAQMPIGAPLAGRKLRVLDAELSPLPIGVAGELCIGGELLARGYLNQPGLSAERFVA 3440 A +PIG+ + R +LDA+L+ +P G GEL +GG LARGY +P LSAERFV Sbjct: 780 GA--ASVPIGSVVGARVAYILDADLALVPQGATGELYVGGAGLARGYHERPALSAERFVP 837 Query: 3441 DPLGDGGARLYRTGDLVRWTHAGQLEYLGRIDHQVKIRGFRIEMGEIESIMLAQPEVREA 3500 DP G RLYRTGDLVR GQ+EY+GRIDHQVKIRGFRIE+GEIE+ +L P+VREA Sbjct: 838 DPFAAEGGRLYRTGDLVRLCDNGQVEYVGRIDHQVKIRGFRIELGEIEARLLEHPQVREA 897 Query: 3501 VVVAREGVGSLQLVAYVTPQHGRHIETAE--LRECLVRH----LPDYMVPAALVVLPALP 3554 +V+A + QL YV E A+ LRE L H LPDYMVPA L++L +LP Sbjct: 898 LVLALDSPSGKQLAGYVASAVAEQDEDAQAALREALKTHLKQQLPDYMVPAHLLLLASLP 957 Query: 3555 LNANGKVDRKALPEPVYE-SRTGHEPPQGECEQALAAIWAEVLGLPAVGRHDNFFELGGH 3613 L ANGK+DR+ALP P +R +E P+ EQ LA +W EVL + VG DNFFELGG Sbjct: 958 LTANGKLDRRALPAPDPALNRQAYEAPRSVLEQQLAGVWREVLNVERVGLGDNFFELGGD 1017 Query: 3614 SLSILRIQSRIQQQFPASALPLRSHFDHPTIAAFA 3648 S+ +++ SR +Q R F H T+ + A Sbjct: 1018 SILSIQVVSRARQL--GIHFSPRDLFQHQTVQSLA 1050 Score = 491 bits (1263), Expect = e-137, Method: Compositional matrix adjust. Identities = 486/1550 (31%), Positives = 717/1550 (46%), Gaps = 147/1550 (9%) Query: 1559 PLSPMQSGMLFHSVSEPDNAAYTMQMQVALEA-LQPERFRAAWQAVLDRHAILRSAILQR 1617 PLS Q M F EPD+ AY + L L RF AA QA++ RH LR+ Sbjct: 10 PLSYSQQRMWFLWQLEPDSPAYNVGGLARLSGPLDVARFEAALQALVQRHETLRTTFPSV 69 Query: 1618 DDAPLQWVARR--VVLPWQLRDCRHSPDLAAELDELARREREAGFDLARPPLMRLMLVST 1675 D P+Q V + + WQ L LA E FDL PL+R+ +V Sbjct: 70 DGVPVQRVHGDGGLHMDWQDFSALDRDSRQQHLQTLADSEAHRPFDLESGPLLRVCMVKM 129 Query: 1676 GEQGYHLIWTVHHLLLDGWSTSQLLGEVLRHYAGQTLD-----EPV-AAYGDYI----RW 1725 E+ ++L+ T+HH++ +GW+ E+ Y D EP+ Y DY W Sbjct: 130 AEREHYLVVTLHHIVTEGWAMDIFARELGALYEAFLDDRESPLEPLPVQYLDYSVWQREW 189 Query: 1726 LQGRDQQASRHHWQSLLHRLQEPSLLVARLPPAKQPNRARDYRQYTCCLGQAQTRRLVEF 1785 L+ ++Q +W++ L + P L + P + P ++ Y L R+ F Sbjct: 190 LESGERQRQLDYWKAQLGN-EHPLLELPGDRP-RPPVQSHQGDLYRFDLSPELAERVRRF 247 Query: 1786 ARARHLTLSTLVQAAWALLLQRYAGHGTVCFGATTAGRPMDLAGAESMLGLFINTLPVVT 1845 AR LT+ + A A LL RY+G + GA A R +E ++G F+NT + Sbjct: 248 NAARGLTMFMTMTATLAALLYRYSGQQDLRIGAPVANRIR--PESEGLIGAFLNTQVLRC 305 Query: 1846 TLTPQTALDEWLQQLQRQSAQSREHEYTPLYEI----QRLAGHSGQSLFDTVVVFENYPV 1901 L Q ++ E L+Q+++ + H+ P + Q + LF + + + Sbjct: 306 RLDGQMSVGELLEQVRQTVIDGQSHQDLPFDHLVEALQPPRSAAYNPLFQVMCNVQRWEF 365 Query: 1902 DAALHSQEVDKLVVGEVRFSSGN----HYPLTLRVS-LAEQLQIDFLHDTGMIAPELLAR 1956 Q+ +L V + + + + L L V+ L ++L + + +AR Sbjct: 366 ------QQTRQLAGMTVEYIANDARATKFDLNLEVTDLDQRLGCCLTYSRDLFDEPRIAR 419 Query: 1957 MAAQFTSLLEQFSQDDGETRRRRLADLSLTD-------LPAPLQGPTIRADDVIERWAAQ 2009 MA + +LLE D +RR+A+L L L A G D + +AA+ Sbjct: 420 MAGHWQNLLEALLGDP----QRRIAELPLFAAEERKQLLLAGTAGEAGLQDTLHGLFAAR 475 Query: 2010 VSQQPGAAALTDGNHALDMAGLCAWVEQMAQQMRQRGIGCEDRVAIHAERSCAFVVAVLA 2069 V+ P A ALT L A L A ++A+ +R G+G E RV + ERS VV +LA Sbjct: 476 VAASPQAPALTFAGQTLSYAELDARSNRLARVLRSHGVGPEVRVGLALERSLEMVVGLLA 535 Query: 2070 TLRVGAAYVPLDPALPAERLHYQLQDSAAVLLLSATA---------------------PD 2108 L+ G AYVPLDP P ERL Y ++DS LLLS A P Sbjct: 536 ILKAGGAYVPLDPEYPLERLQYMIEDSGVRLLLSHAALFEALGELPAGVARWCLEEDGPA 595 Query: 2109 WAASVPVLPLASLHGVPKRVPYCWPAVHPGQAAYVIYTSGSTGRPKGVVVSRGALANYVA 2168 A P PLA+L G P AY+IYTSGSTG+PKGV VS G +A + A Sbjct: 596 LDAEDPA-PLAALSG-------------PQHQAYLIYTSGSTGKPKGVAVSHGEIAMHCA 641 Query: 2169 GVLERLDLREQDRSMAMVSTVGADLGHTVLFGALCSGRLLHLIPPQCSFDPDAMASYMEQ 2228 V+E +R +D + S +L LC R+ ++ Q + + + + Sbjct: 642 AVIECFGMRAEDCELHFYSINFDAASERLLAPLLCGARV--VLRAQGQWGAEEICELIRA 699 Query: 2229 HQVDVLKIVPSHLQALLH-AASPASVLPRSRLVLGGEASRKPLLAHIASLRPQCRVMNHY 2287 V +L PS+ L S LP + GGEA L I N Y Sbjct: 700 EGVSILGFTPSYGSQLAQWLESQGRQLPVRMCITGGEALTGEHLQRIRQAFAPASFFNAY 759 Query: 2288 GPTETTVGVLTQEASSALDE-ADSLPIGQPIAQARAYVLDAELQPVPQGVAGELYLAGHG 2346 GPTET V L A L+E A S+PIG + AY+LDA+L VPQG GELY+ G G Sbjct: 760 GPTETVVMPLACLAPERLEEGAASVPIGSVVGARVAYILDADLALVPQGATGELYVGGAG 819 Query: 2347 VARAYQQRPAQSAERFVAD-LLEPGQRMYRSGDRVRQLADGSLEFLGRLDGQIKVRGYRV 2405 +AR Y +RPA SAERFV D G R+YR+GD VR +G +E++GR+D Q+K+RG+R+ Sbjct: 820 LARGYHERPALSAERFVPDPFAAEGGRLYRTGDLVRLCDNGQVEYVGRIDHQVKIRGFRI 879 Query: 2406 ELREIAALLQSLEAVAQAEVVVHSEPAQPGPDGEEVAPQIIAYLVPM--GGQTLDVADLR 2463 EL EI A L V +A V+ A P G+++A + + + Q L+ Sbjct: 880 ELGEIEARLLEHPQVREALVL-----ALDSPSGKQLAGYVASAVAEQDEDAQAALREALK 934 Query: 2464 QQLATRLPDYMMPTALVPLHVMPLTPNGKLDRQALPRPDSTAT-SVYEAARGPLEETLAG 2522 L +LPDYM+P L+ L +PLT NGKLDR+ALP PD YEA R LE+ LAG Sbjct: 935 THLKQQLPDYMVPAHLLLLASLPLTANGKLDRRALPAPDPALNRQAYEAPRSVLEQQLAG 994 Query: 2523 LWAELLGLPQVGRNDDFFALGGDSILVLKLVARARKRDVKLAPKMLFEGKTP---AGVAQ 2579 +W E+L + +VG D+FF LGGDSIL +++V+RAR+ + +P+ LF+ +T A VA+ Sbjct: 995 VWREVLNVERVGLGDNFFELGGDSILSIQVVSRARQLGIHFSPRDLFQHQTVQSLAAVAR 1054 Query: 2580 LLTAGSGAAGGVERIMPLPPAQRNGLLPASYAQARQWFLWQLD-PGSSAYHINGALRLC- 2637 A G V+ L P Q W D P + H N AL L Sbjct: 1055 HSQASQAEQGPVQGDSALTPIQH----------------WFFDLPLARREHWNQALLLQP 1098 Query: 2638 -GTLDEAALEQAFSRLLERHPSLRTVLRADADGQVLQWVQPHACLAFKRIDLEPLAEGPR 2696 +D L ++ RL+E+H +LR R DG +W+ H L + E L P Sbjct: 1099 RQAIDLGLLRKSLQRLVEQHDALRLAFR-QVDG---EWLAQHRPLR----EQELLWHVPV 1150 Query: 2697 QARLH-AEVASLCRQPFDLEAGPLLRIGLLRESGHRHVLVMVMHHIISDGWSMQLIMDEF 2755 Q+ AE+ + ++ DLE GPLLR L+ L++ +HH++ DG S ++++++ Sbjct: 1151 QSFDECAELFAKAQRSLDLEQGPLLRAVLVDGPAGEQRLLLAIHHLVVDGVSWRVLLEDL 1210 Query: 2756 ASLYGACCQGREAGLPALPLQYADYAAWQRQWMQGGQRETQLRYWQDHLGQSQPSLLLPA 2815 +Y +G E LPA + D+A + + +L +WQ LG QP + P Sbjct: 1211 QQVYRQFAEGAEPALPAKTSAFRDWAGRLQAYAGSESLREELGWWQARLG-GQP-VEWPC 1268 Query: 2816 DHPRRPDGLYRAARHEAV---LPPPLVAALRQRVQSDGGT-LFAVLLAAAQLLMYRYSGQ 2871 D RP G R A E+V L P L Q+ + T + +LL A ++ R+SGQ Sbjct: 1269 D---RPQGDNREALAESVSLRLDPQRTRQLLQQAPAAYRTQVNDLLLTALARVLCRWSGQ 1325 Query: 2872 NDIRLGVPIANRHL----PDTEGVVGFFVNTQVLRAEIDPRQSLARLVQLTRETAQGAQQ 2927 + + R D VG+F + LR + P QS ++ +E + A Sbjct: 1326 PSTLVQLEGHGREALFDDIDLTRSVGWFTSAYPLR--LTPAQSPGESIKAIKEQLR-AVP 1382 Query: 2928 HQDLPFEQLVEVLQP--QRLVGVNPLFQVMFNH-----QRHARPTSHQLPQLTLEPFELE 2980 H+ L + L + P ++ + P + FN+ Q A L Q T P E Sbjct: 1383 HKGLGYGVLRYLADPAVRQAMAALPTAPITFNYLGQFDQSFADALFQPLDQPT-GPIHDE 1441 Query: 2981 EQDAQFELAIDTLEDTDGGLSVSLTYARELFEPQTMATMASHYLVALEAL 3030 + EL++D + G L + TY+RE ++ +T+ +A YL L+AL Sbjct: 1442 QAPLPNELSVDG-QVYGGELVLRWTYSRERYDARTVNELAQAYLAELQAL 1490 >PA2400 [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins Pae Pseudomonas aeruginosa Length = 1317 Score = 983 bits (2542), Expect = 0.0, Method: Compositional matrix adjust. Identities = 585/1321 (44%), Positives = 797/1321 (60%), Gaps = 70/1321 (5%) Query: 2358 SAERFVADLL-EPGQRMYRSGDRVRQLADGSLEFLGRLDGQIKVRGYRVELREIAALLQS 2416 +AERF+ D EPG R+YR+GD R+ DG +E++GR D Q+K+RG+R+EL E+ A L Sbjct: 2 TAERFLPDPFGEPGSRLYRTGDLARRRGDGVIEYMGRADHQVKIRGFRIELGEVEARLLD 61 Query: 2417 LEAVAQAEVVVHSEPAQPGPDGEEVAPQIIAYLVPMGG-----QTLDVADLRQQLATRLP 2471 LE + +A + DG Q++AYLV GG Q +R L LP Sbjct: 62 LEGIREAAALAL--------DG-----QLVAYLVAEGGEDETRQPALRERIRTALRASLP 108 Query: 2472 DYMMPTALVPLHVMPLTPNGKLDRQALPRPDSTATSV-YEAARGPLEETLAGLWAELLGL 2530 DYM+P+ L+ L MPL+PNGKLDR+ALP+PD+ + A LE+ +A +W ELLG+ Sbjct: 109 DYMVPSHLLFLERMPLSPNGKLDRRALPKPDAGLMQRDHMAPASALEKDVAAIWGELLGV 168 Query: 2531 PQVGRNDDFFALGGDSILVLKLVARARKR-DVKLAPKMLFEGKTPAGVAQLLTAGSGAAG 2589 +VG D+FF LGG S+L +LV+R R+ ++++ K LFE G + L G A Sbjct: 169 ERVGLTDNFFELGGHSLLATRLVSRIRQDLGIEVSLKSLFEQPVLQGFVESL--GEKPA- 225 Query: 2590 GVERIMPLPPAQRNGLLPASYAQARQWFLWQLDPGSSAYHINGALRLCGTLDEAALEQAF 2649 + P+ P R LP SYAQ RQWFLWQL+P S+AYHI ALRL G LD AL+++F Sbjct: 226 ---EVPPITPVTREQPLPLSYAQERQWFLWQLEPESAAYHIPAALRLRGGLDVVALQRSF 282 Query: 2650 SRLLERHPSLRTVLRADADGQVLQWVQPHACLAFKRIDLEPLAEGPRQARLHAEVASLCR 2709 RL +RH SLRT R + + +Q V L R +L + + +A + AE+A Sbjct: 283 ERLAQRHESLRTRFRQEG-LRTVQVVDADGQLQVSRHNLANVDDASLRAAVEAEMA---- 337 Query: 2710 QPFDLEAGPLLRIGLLRESGHRHVLVMVMHHIISDGWSMQLIMDEFASLYGACCQGREAG 2769 +PFDL LLRI L + + HVLVMV HHI+SDGWSMQL+++E LY A QGREA Sbjct: 338 RPFDLRTDALLRISLFEVAPNDHVLVMVQHHIVSDGWSMQLMVEELVQLYAAYSQGREAA 397 Query: 2770 LPALPLQYADYAAWQRQWMQGGQRETQLRYWQDHLGQSQPSLLLPADHPRRPDGLYRAAR 2829 LPALP+QY DYA WQR+WM+ G+RE QL YW LG QP L LP D PR + +R AR Sbjct: 398 LPALPIQYPDYAVWQREWMEAGERERQLAYWIGLLGGEQPVLELPFDRPRPAEQSFRGAR 457 Query: 2830 HEAVLPPPLVAALRQRVQSDGGTLFAVLLAAAQLLMYRYSGQNDIRLGVPIANRHLPDTE 2889 E L L+ Q G + F +LLA+ Q L+YRYSGQ+DIR+GVP+ANR+ +TE Sbjct: 458 LEFELGAERARRLKALAQRQGASTFMLLLASFQALLYRYSGQSDIRVGVPVANRNRVETE 517 Query: 2890 GVVGFFVNTQVLRAEIDPRQSLARLVQLTRETAQGAQQHQDLPFEQLVEVLQPQRLVGVN 2949 ++GFFVNTQVL+A+ID + RL+ R+ + AQ HQDLPFEQLVE LQP+R + + Sbjct: 518 RLIGFFVNTQVLKADIDGQMGFDRLLHQVRQRSLEAQAHQDLPFEQLVEALQPERSLSHS 577 Query: 2950 PLFQVMFNHQRHARPTSHQLPQ---LTLEPFELEEQDAQFELAIDTLEDTDGGLSVSLTY 3006 PLFQV+FN+Q A H LP+ L++E E AQF+L +DT E ++ + +L Y Sbjct: 578 PLFQVLFNYQ--AERGEHGLPEVAGLSIEEQAWESHTAQFDLVLDTCE-SESDIWAALVY 634 Query: 3007 ARELFEPQTMATMASHYLVALEALASQPQCRVGEIDWLGPAERSRLAA-WGDKVSPYATP 3065 A +LF+ T + H+ L+A+ + P R+GE+D L ER + W S Y Sbjct: 635 ATDLFDASTAERLVRHWQNLLDAILAMPDARLGELDMLDREEREVIGQLWNRSDSGYPAT 694 Query: 3066 AVITTRIAQRASIQPDAVALISGNRSMSYGQLNTRVNQLAHYLLQRGLQPEARVGVALER 3125 ++ R+A+RA + PDAVA+I ++Y +L+ R N+LAH L+ RG+ PE RV +A++R Sbjct: 695 PLVHQRVAERARMAPDAVAVIFDEEKLTYAELDNRANRLAHALIARGVGPEVRVAIAMQR 754 Query: 3126 SADMVVAVLAILKAGATYVPLDPDYPVQRLAAIIEDSALSLLLSQTSVSQRLPGGRAEQT 3185 SA+++VA LA+LKAG YVPLD +YP +RL +++DS LLL+ + + +RLP Sbjct: 755 SAEIMVAFLAVLKAGGAYVPLDIEYPRERLLYMMQDSRAHLLLTHSHLLERLPIPEGLSC 814 Query: 3186 LYLDQLDLQAQ-PHDEPDVTIHSDSLAYVIYTSGSTGRPKGVGISHRCLMEHGQIAADFF 3244 L +D+ + A P +P+V +H D+LAYVIYTSGSTG PKGV +SH L+ H + + Sbjct: 815 LSVDREEEWAGFPAHDPEVALHGDNLAYVIYTSGSTGMPKGVAVSHGPLIAHIVATGERY 874 Query: 3245 GLTPQDCMLQFSTLNFDGCIEQLFPPLLVGAAVVLRGPELWDSQRLHVELLAHRISVLDL 3304 +TP+DC L F + FDG E PL+ GA V++R LW +R + E+ H ++V Sbjct: 875 EMTPEDCELHFMSFAFDGSHEGWMHPLINGARVLIRDDSLWLPERTYAEMHRHGVTVGVF 934 Query: 3305 TTAYWLLLVQDFARMGVPDYGVLRRVHVGGEAMPPEGIK-AWRDAGLAQVELFNTYGPTE 3363 Y L + R G P +R GG+A+ AWR L LFN YGPTE Sbjct: 935 PPVYLQQLAEHAERDGNPP--PVRVYCFGGDAVAQASYDLAWR--ALKPKYLFNGYGPTE 990 Query: 3364 ATVTASILSCAPYVSGQTVLPAQMPIGAPLAGRKLRVLDAELSPLPIGVAGELCIGGELL 3423 VT + +G A MPIG L R +LD +L+ LP+GVAGEL +GGE + Sbjct: 991 TVVTPLLWKAR---AGDACGAAYMPIGTLLGNRSGYILDGQLNLLPVGVAGELYLGGEGV 1047 Query: 3424 ARGYLNQPGLSAERFVADPLGDGGARLYRTGDLVRWTHAGQLEYLGRIDHQVKIRGFRIE 3483 ARGYL +P L+AERFV DP G G+RLYR+GDL R G ++YLGR+DHQVKIRGFRIE Sbjct: 1048 ARGYLERPALTAERFVPDPFGAPGSRLYRSGDLTRGRADGVVDYLGRVDHQVKIRGFRIE 1107 Query: 3484 MGEIESIMLAQPEVREAVVVAREGVGSLQLVAYVTPQHGRHIET--------AELRECLV 3535 +GEIE+ + P VREAVVVA+ G QLV YV Q ++ A+L+ L Sbjct: 1108 LGEIEARLREHPAVREAVVVAQPGAVGQQLVGYVVAQEPAVADSPEAQAECRAQLKTALR 1167 Query: 3536 RHLPDYMVPAALVVLPALPLNANGKVDRKALPEP-------VYESRTGHEPPQGECEQAL 3588 LP+YMVP+ L+ L +PL NGK+DRK LP+P VY + P+ + EQ + Sbjct: 1168 ERLPEYMVPSHLLFLARMPLTPNGKLDRKGLPQPDASLLQQVYVA------PRSDLEQQV 1221 Query: 3589 AAIWAEVLGLPAVGRHDNFFELGGHSLSILRIQSRIQQQFPASALPLRSHFDHPTIAAFA 3648 A IWAEVL L VG DNFFELGGHSL ++ R++++ +P++S F T+ F Sbjct: 1222 AGIWAEVLQLQQVGLDDNFFELGGHSLLATQVIGRLRERLHLE-VPIKSMFTAETLGEFC 1280 Query: 3649 Q 3649 Sbjct: 1281 H 1281 Score = 770 bits (1989), Expect = 0.0, Method: Compositional matrix adjust. Identities = 466/1062 (43%), Positives = 635/1062 (59%), Gaps = 44/1062 (4%) Query: 51 PAPLSFAQQRLWYLWKLTPQSSAYHLAGGLRLQGPLEAAALERAVDALALHHPALRTVLR 110 P PLS+AQ+R W+LW+L P+S+AYH+ LRL+G L+ AL+R+ + LA H +LRT R Sbjct: 238 PLPLSYAQERQWFLWQLEPESAAYHIPAALRLRGGLDVVALQRSFERLAQRHESLRTRFR 297 Query: 111 EDADGNVTQTVLPACAWSLSRQDLSLLPAHRRQDALREQVQRLCSRPFELDGGALVRACL 170 ++ V Q V +SR +L A+ +LR V+ +RPF+L AL+R L Sbjct: 298 QEGLRTV-QVVDADGQLQVSRHNL----ANVDDASLRAAVEAEMARPFDLRTDALLRISL 352 Query: 171 LQVDEQEHQLIVVMHHIISDAQSTQLILAELLALYQAARQGQAISAAWHGPDLGDYAVWQ 230 +V +H L++V HHI+SD S QL++ EL+ LY A QG+ + DYAVWQ Sbjct: 353 FEVAPNDHVLVMVQHHIVSDGWSMQLMVEELVQLYAAYSQGREAALPALPIQYPDYAVWQ 412 Query: 231 RQCLNSTQAERQLAWWKAQLGNSSPVLELPTDHARRPDGQYGAASWRIVLEPALLDALRR 290 R+ + + + ERQLA+W LG PVLELP D R + + A L L+ Sbjct: 413 REWMEAGERERQLAYWIGLLGGEQPVLELPFDRPRPAEQSFRGARLEFELGAERARRLKA 472 Query: 291 RAQGQGCSLFVVLLCAFQALLYRHTSQRDVRVGVPVSHRLRSELAAAVGFFVDTQVLRAE 350 AQ QG S F++LL +FQALLYR++ Q D+RVGVPV++R R E +GFFV+TQVL+A+ Sbjct: 473 LAQRQGASTFMLLLASFQALLYRYSGQSDIRVGVPVANRNRVETERLIGFFVNTQVLKAD 532 Query: 351 LAGQTTLESLLAQVRDTSFAAQAHRDIPLERLVEVLQPERSIGRTPLFQVMFNHLREQAD 410 + GQ + LL QVR S AQAH+D+P E+LVE LQPERS+ +PLFQV+FN+ E+ + Sbjct: 533 IDGQMGFDRLLHQVRQRSLEAQAHQDLPFEQLVEALQPERSLSHSPLFQVLFNYQAERGE 592 Query: 411 -GSQSWPGLSVQRLDFDAAVAQFELTLETSEEANGELSATFRYARELFDESSIARMAQHY 469 G GLS++ +++ AQF+L L+T E+ ++ A YA +LFD S+ R+ +H+ Sbjct: 593 HGLPEVAGLSIEEQAWESHTAQFDLVLDTC-ESESDIWAALVYATDLFDASTAERLVRHW 651 Query: 470 VAILQALATQPQLRVAELQLRGAEEDRQLHSWGVNNEQHAEVMEPVHEQIARQARRQPEA 529 +L A+ P R+ EL + EE + ++ VH+++A +AR P+A Sbjct: 652 QNLLDAILAMPDARLGELDMLDREEREVIGQLWNRSDSGYPATPLVHQRVAERARMAPDA 711 Query: 530 TALLFGRQQLSYGALERRANQLAHRLIRLGAGPEVKVGIAVERSLEMVIGLLGILKAGAA 589 A++F ++L+Y L+ RAN+LAH LI G GPEV+V IA++RS E+++ L +LKAG A Sbjct: 712 VAVIFDEEKLTYAELDNRANRLAHALIARGVGPEVRVAIAMQRSAEIMVAFLAVLKAGGA 771 Query: 590 YVPLDPEYPAQRLQYMMQDSGMRLLLTQQHVLPTLPPLAGLPVLALDQLDLDDE-----A 644 YVPLD EYP +RL YMMQDS LLLT H+L LP GL L++D+ ++E A Sbjct: 772 YVPLDIEYPRERLLYMMQDSRAHLLLTHSHLLERLPIPEGLSCLSVDR---EEEWAGFPA 828 Query: 645 HQPPAVRVHGENLAYVIYTSGSTGQPKGVANRHCALRNRLAWMQQAYRLEPHDTVLQKTP 704 H P V +HG+NLAYVIYTSGSTG PKGVA H L + + Y + P D L Sbjct: 829 HD-PEVALHGDNLAYVIYTSGSTGMPKGVAVSHGPLIAHIVATGERYEMTPEDCELHFMS 887 Query: 705 FSFDVSVWEFFWPLMIGARLALAQPGDHRD-----PARLVEQIQRHAVSTLHFVPSMLQA 759 F+FD S + PL+ GAR+ + RD P R ++ RH V+ F P LQ Sbjct: 888 FAFDGSHEGWMHPLINGARVLI------RDDSLWLPERTYAEMHRHGVTVGVFPPVYLQQ 941 Query: 760 FLAHDEIEGCSSLHRLIC-SGEALPVEAQQGVFARLPQVALYNLYGPTEAAIDVTHWTCR 818 H E +G R+ C G+A+ + + L L+N YGPTE + W R Sbjct: 942 LAEHAERDGNPPPVRVYCFGGDAVAQASYDLAWRALKPKYLFNGYGPTETVVTPLLWKAR 1001 Query: 819 AD---GRSQVPIGRPISSIRTLVLDGDLNLAPQGVPGELYLGGIGLARGYLGRAGLSAER 875 A G + +PIG + + +LDG LNL P GV GELYLGG G+ARGYL R L+AER Sbjct: 1002 AGDACGAAYMPIGTLLGNRSGYILDGQLNLLPVGVAGELYLGGEGVARGYLERPALTAER 1061 Query: 876 FVADPFSADGERLYRTGDLVRWNREGQLDYLGRLDHQVKIRGLRIELGEIEARLLAQPGV 935 FV DPF A G RLYR+GDL R +G +DYLGR+DHQVKIRG RIELGEIEARL P V Sbjct: 1062 FVPDPFGAPGSRLYRSGDLTRGRADGVVDYLGRVDHQVKIRGFRIELGEIEARLREHPAV 1121 Query: 936 REAVVVARESAGTSRLVAYVSGTDLVAAT-----------LRSALTKDLPDYMVPALIEV 984 REAVVVA+ A +LV YV + A L++AL + LP+YMVP+ + Sbjct: 1122 REAVVVAQPGAVGQQLVGYVVAQEPAVADSPEAQAECRAQLKTALRERLPEYMVPSHLLF 1181 Query: 985 LEHLPLNANGKVDRRALPDP-AQPLQRAYEAPRGQAEQVLAAVWAEVLGLQQVGRHDNFF 1043 L +PL NGK+DR+ LP P A LQ+ Y APR EQ +A +WAEVL LQQVG DNFF Sbjct: 1182 LARMPLTPNGKLDRKGLPQPDASLLQQVYVAPRSDLEQQVAGIWAEVLQLQQVGLDDNFF 1241 Query: 1044 ELGGDSILSLQIVAGLRRRGSQLAP-RLIFERQTIAQLAPAI 1084 ELGG S+L+ Q++ LR R P + +F +T+ + + Sbjct: 1242 ELGGHSLLATQVIGRLRERLHLEVPIKSMFTAETLGEFCHGV 1283 Score = 390 bits (1002), Expect = e-107, Method: Compositional matrix adjust. Identities = 352/1075 (32%), Positives = 523/1075 (48%), Gaps = 99/1075 (9%) Query: 1559 PLSPMQSGMLFHSVSEPDNAAY----TMQMQVALEALQPERFRAAWQAVLDRHAILRSAI 1614 PLS Q F EP++AAY ++++ L+ + +R +++ + RH LR+ Sbjct: 240 PLSYAQERQWFLWQLEPESAAYHIPAALRLRGGLDVVALQR---SFERLAQRHESLRTRF 296 Query: 1615 LQRDDAPLQWVARRVVLPWQLRDCRHSPDLAAELDELARR-----EREAGFDLARPPLMR 1669 Q +Q V QL+ RH+ A +D+ + R E FDL L+R Sbjct: 297 RQEGLRTVQVVD----ADGQLQVSRHN---LANVDDASLRAAVEAEMARPFDLRTDALLR 349 Query: 1670 LMLVSTGEQGYHLIWTVHHLLLDGWSTSQLLGEVLRHYAGQTLDEPVA------AYGDYI 1723 + L + L+ HH++ DGWS ++ E+++ YA + A Y DY Sbjct: 350 ISLFEVAPNDHVLVMVQHHIVSDGWSMQLMVEELVQLYAAYSQGREAALPALPIQYPDYA 409 Query: 1724 ----RWLQGRDQQASRHHWQSLLHRLQEP-SLLVARLPPAKQPNRARDYRQYTCCLGQAQ 1778 W++ +++ +W LL Q L R PA+Q R + LG + Sbjct: 410 VWQREWMEAGERERQLAYWIGLLGGEQPVLELPFDRPRPAEQSFRGA---RLEFELGAER 466 Query: 1779 TRRLVEFARARHLTLSTLVQAAWALLLQRYAGHGTVCFGATTAGRPMDLAGAESMLGLFI 1838 RRL A+ + + L+ A++ LL RY+G + G A R + E ++G F+ Sbjct: 467 ARRLKALAQRQGASTFMLLLASFQALLYRYSGQSDIRVGVPVANR--NRVETERLIGFFV 524 Query: 1839 NTLPVVTTLTPQTALDEWLQQLQRQSAQSREHEYTPLYEI------QRLAGHSGQSLFDT 1892 NT + + Q D L Q++++S +++ H+ P ++ +R HS LF Sbjct: 525 NTQVLKADIDGQMGFDRLLHQVRQRSLEAQAHQDLPFEQLVEALQPERSLSHS--PLFQ- 581 Query: 1893 VVVFENYPVDAALHS-QEVDKLVVGEVRFSSGN-HYPLTLRVSLAEQ-LQIDFLHDTGMI 1949 V NY + H EV L + E + S + L L +E + ++ T + Sbjct: 582 --VLFNYQAERGEHGLPEVAGLSIEEQAWESHTAQFDLVLDTCESESDIWAALVYATDLF 639 Query: 1950 APELLARMAAQFTSLLE-----------QFSQDDGETRR--RRLADLSLTDLPA-PLQGP 1995 R+ + +LL+ + D E R +L + S + PA PL Sbjct: 640 DASTAERLVRHWQNLLDAILAMPDARLGELDMLDREEREVIGQLWNRSDSGYPATPL--- 696 Query: 1996 TIRADDVIERWAAQVSQQPGAAALTDGNHALDMAGLCAWVEQMAQQMRQRGIGCEDRVAI 2055 V +R A + P A A+ L A L ++A + RG+G E RVAI Sbjct: 697 ------VHQRVAERARMAPDAVAVIFDEEKLTYAELDNRANRLAHALIARGVGPEVRVAI 750 Query: 2056 HAERSCAFVVAVLATLRVGAAYVPLDPALPAERLHYQLQDSAAVLLLSATA-------PD 2108 +RS +VA LA L+ G AYVPLD P ERL Y +QDS A LLL+ + P+ Sbjct: 751 AMQRSAEIMVAFLAVLKAGGAYVPLDIEYPRERLLYMMQDSRAHLLLTHSHLLERLPIPE 810 Query: 2109 WAASVPVLPLASLHGVPKRVPYCWPAVHPGQAAYVIYTSGSTGRPKGVVVSRGALANYVA 2168 + + V G P P A+H AYVIYTSGSTG PKGV VS G L ++ Sbjct: 811 GLSCLSVDREEEWAGFPAHDPEV--ALHGDNLAYVIYTSGSTGMPKGVAVSHGPLIAHIV 868 Query: 2169 GVLERLDLREQDRSMAMVSTVGADLGHTVLFGALCSGRLLHLIPPQCSFDPDAMASYMEQ 2228 ER ++ +D + +S D H L +G + LI + P+ + M + Sbjct: 869 ATGERYEMTPEDCELHFMS-FAFDGSHEGWMHPLINGARV-LIRDDSLWLPERTYAEMHR 926 Query: 2229 HQVDVLKIVPSHLQALL-HAASPASVLPRSRLVLGGEA-SRKPLLAHIASLRPQCRVMNH 2286 H V V P +LQ L HA + P GG+A ++ +L+P+ + N Sbjct: 927 HGVTVGVFPPVYLQQLAEHAERDGNPPPVRVYCFGGDAVAQASYDLAWRALKPKY-LFNG 985 Query: 2287 YGPTETTVGVLTQEASSA-LDEADSLPIGQPIAQARAYVLDAELQPVPQGVAGELYLAGH 2345 YGPTET V L +A + A +PIG + Y+LD +L +P GVAGELYL G Sbjct: 986 YGPTETVVTPLLWKARAGDACGAAYMPIGTLLGNRSGYILDGQLNLLPVGVAGELYLGGE 1045 Query: 2346 GVARAYQQRPAQSAERFVADLL-EPGQRMYRSGDRVRQLADGSLEFLGRLDGQIKVRGYR 2404 GVAR Y +RPA +AERFV D PG R+YRSGD R ADG +++LGR+D Q+K+RG+R Sbjct: 1046 GVARGYLERPALTAERFVPDPFGAPGSRLYRSGDLTRGRADGVVDYLGRVDHQVKIRGFR 1105 Query: 2405 VELREIAALLQSLEAVAQAEVVVHSEPAQPGPDGEEVAPQIIAYLVPMGGQTLDVADLRQ 2464 +EL EI A L+ AV +A VV AQPG G+++ ++A + A+ R Sbjct: 1106 IELGEIEARLREHPAVREAVVV-----AQPGAVGQQLVGYVVAQEPAVADSPEAQAECRA 1160 Query: 2465 QLAT----RLPDYMMPTALVPLHVMPLTPNGKLDRQALPRPD-STATSVYEAARGPLEET 2519 QL T RLP+YM+P+ L+ L MPLTPNGKLDR+ LP+PD S VY A R LE+ Sbjct: 1161 QLKTALRERLPEYMVPSHLLFLARMPLTPNGKLDRKGLPQPDASLLQQVYVAPRSDLEQQ 1220 Query: 2520 LAGLWAELLGLPQVGRNDDFFALGGDSILVLKLVARARKR-DVKLAPKMLFEGKT 2573 +AG+WAE+L L QVG +D+FF LGG S+L +++ R R+R +++ K +F +T Sbjct: 1221 VAGIWAEVLQLQQVGLDDNFFELGGHSLLATQVIGRLRERLHLEVPIKSMFTAET 1275 Score = 220 bits (561), Expect = 4e-56, Method: Compositional matrix adjust. Identities = 205/611 (33%), Positives = 300/611 (49%), Gaps = 64/611 (10%) Query: 871 LSAERFVADPFSADGERLYRTGDLVRWNREGQLDYLGRLDHQVKIRGLRIELGEIEARLL 930 ++AERF+ DPF G RLYRTGDL R +G ++Y+GR DHQVKIRG RIELGE+EARLL Sbjct: 1 MTAERFLPDPFGEPGSRLYRTGDLARRRGDGVIEYMGRADHQVKIRGFRIELGEVEARLL 60 Query: 931 AQPGVREAVVVARESAGTSRLVAYVSGTD-----LVAATLRSALTKDLPDYMVPALIEVL 985 G+REA +A + + LVA G D + +R+AL LPDYMVP+ + L Sbjct: 61 DLEGIREAAALALDGQLVAYLVAE-GGEDETRQPALRERIRTALRASLPDYMVPSHLLFL 119 Query: 986 EHLPLNANGKVDRRALPDP-AQPLQRAYEAPRGQAEQVLAAVWAEVLGLQQVGRHDNFFE 1044 E +PL+ NGK+DRRALP P A +QR + AP E+ +AA+W E+LG+++VG DNFFE Sbjct: 120 ERMPLSPNGKLDRRALPKPDAGLMQRDHMAPASALEKDVAAIWGELLGVERVGLTDNFFE 179 Query: 1045 LGGDSILSLQIVAGLRRR-GSQLAPRLIFERQTIAQLAPAIAHSTA--PQLHAQVSVQGE 1101 LGG S+L+ ++V+ +R+ G +++ + +FE+ + ++ A P + V+ + Sbjct: 180 LGGHSLLATRLVSRIRQDLGIEVSLKSLFEQPVLQGFVESLGEKPAEVPPI-TPVTREQP 238 Query: 1102 LPLLPIQAE--FFAMDIPVRHHWNQSILLATDAPLDMAALNTALQAVVAHHDSLRLRYTR 1159 LPL Q F P ++ L LD+ AL + + + H+SLR R+ + Sbjct: 239 LPLSYAQERQWFLWQLEPESAAYHIPAALRLRGGLDVVALQRSFERLAQRHESLRTRFRQ 298 Query: 1160 ---------DDQGQW---RQTYGQHDPAQLRELLWVRQGLPGNAIAPLCEQAQRSLNLAR 1207 D GQ R D A LR A + + R +L Sbjct: 299 EGLRTVQVVDADGQLQVSRHNLANVDDASLR--------------AAVEAEMARPFDLRT 344 Query: 1208 GPLLRAVAMELEEGGWRLLLVIHHLVVDGVSWRILLADLQQAYRQCVALEPLVLPARTAS 1267 LLR E+ L++V HH+V DG S ++++ +L Q Y LPA Sbjct: 345 DALLRISLFEVAPNDHVLVMVQHHIVSDGWSMQLMVEELVQLYAAYSQGREAALPALPIQ 404 Query: 1268 YQQWAHVLQG---RHGALLPQRPYWQAQM---QPPSVLPCDDAG-GEATMR-QRQEMSFG 1319 Y +A V Q G Q YW + QP LP D E + R R E G Sbjct: 405 YPDYA-VWQREWMEAGERERQLAYWIGLLGGEQPVLELPFDRPRPAEQSFRGARLEFELG 463 Query: 1320 LDK-ERTNALLRRVPAAYRTRINDVLLTALVRALCGWSGLSEIQVDIEGHGREDGTGQLD 1378 ++ R AL +R A+ +LL + L +SG S+I+V + R +++ Sbjct: 464 AERARRLKALAQRQGASTFM----LLLASFQALLYRYSGQSDIRVGVPVANR----NRVE 515 Query: 1379 LSRTVGWF--TSVFPLRLSGAGTPQQALKRIKE-SLRAVPEAGLGFGLLRQAGNLPGS-S 1434 R +G+F T V + G + L ++++ SL A L F L +A S S Sbjct: 516 TERLIGFFVNTQVLKADIDGQMGFDRLLHQVRQRSLEAQAHQDLPFEQLVEALQPERSLS 575 Query: 1435 SSP---VIFNY 1442 SP V+FNY Sbjct: 576 HSPLFQVLFNY 586 Score = 188 bits (477), Expect = 2e-46, Method: Compositional matrix adjust. Identities = 107/226 (47%), Positives = 144/226 (63%), Gaps = 13/226 (5%) Query: 3433 LSAERFVADPLGDGGARLYRTGDLVRWTHAGQLEYLGRIDHQVKIRGFRIEMGEIESIML 3492 ++AERF+ DP G+ G+RLYRTGDL R G +EY+GR DHQVKIRGFRIE+GE+E+ +L Sbjct: 1 MTAERFLPDPFGEPGSRLYRTGDLARRRGDGVIEYMGRADHQVKIRGFRIELGEVEARLL 60 Query: 3493 AQPEVREAVVVAREGVGSLQLVAYVTPQHGRHIETAE------LRECLVRHLPDYMVPAA 3546 +REA +A +G QLVAY+ + G ET + +R L LPDYMVP+ Sbjct: 61 DLEGIREAAALALDG----QLVAYLVAEGGED-ETRQPALRERIRTALRASLPDYMVPSH 115 Query: 3547 LVVLPALPLNANGKVDRKALPEP-VYESRTGHEPPQGECEQALAAIWAEVLGLPAVGRHD 3605 L+ L +PL+ NGK+DR+ALP+P + H P E+ +AAIW E+LG+ VG D Sbjct: 116 LLFLERMPLSPNGKLDRRALPKPDAGLMQRDHMAPASALEKDVAAIWGELLGVERVGLTD 175 Query: 3606 NFFELGGHSLSILRIQSRIQQQFPASALPLRSHFDHPTIAAFAQQL 3651 NFFELGGHSL R+ SRI+Q + L+S F+ P + F + L Sbjct: 176 NFFELGGHSLLATRLVSRIRQDL-GIEVSLKSLFEQPVLQGFVESL 220 >all2644_2 [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins Nos Nostoc sp. PCC 7120 Length = 1542 Score = 890 bits (2299), Expect = 0.0, Method: Compositional matrix adjust. Identities = 583/1562 (37%), Positives = 829/1562 (53%), Gaps = 96/1562 (6%) Query: 53 PLSFAQQRLWYLWKLTPQSSAYHLAGGLRLQGPLEAAALERAVDALALHHPALRTVLRED 112 PLSFAQQR W L +L P S Y++ ++++G + +L+R+ + LR+ + Sbjct: 6 PLSFAQQRFWILAQLEPDSPFYNIPLAVQIRGDIHLDSLQRSFTEVVRRQEILRSHFL-N 64 Query: 113 ADGNVTQTVLPACAWSLSRQDLSLLPAHRRQDALREQVQRLCSRPFELDGGALVRACLLQ 172 DG + C ++ DL LP +Q ++E + +PF+L G L R L++ Sbjct: 65 VDGQPVLRIADVCDVNIPVIDLQGLPEFEQQQQVQELARTQAQQPFDL-AGLLWRVRLVK 123 Query: 173 VDEQEHQLIVVMHHIISDAQSTQLILAELLALY--------QAARQGQAISAAWHGPDLG 224 + E L++ +HHII+DA S L++ E+ + Q R+ + I Sbjct: 124 LGEGNQVLLLTLHHIIADAWSVGLLVREISRAFAERPAGKAQRRREEERIQYV------- 176 Query: 225 DYAVWQRQCLNSTQAERQLAWWKAQLGNSSPVLELPTDHARRPDGQYGAASWRIVLEPAL 284 D+A WQR+ L E L +W+ QL ++ +LELPTD+ R + A + L L Sbjct: 177 DFAFWQREWLRGRVLEEHLEYWRGQLESAPVMLELPTDYPRPAVQSFRGAVYGFGLSAEL 236 Query: 285 LDALRRRAQGQGCSLFVVLLCAFQALLYRHTSQRDVRVGVPVSHRLRSELAAAVGFFVDT 344 L+ ++ +LF+ LL + LLYR++ D+ VG P+++R R E +G F +T Sbjct: 237 TQGLQGLSRRYHSTLFMTLLAVWNVLLYRYSGDDDIVVGSPIANRNRVETEGLIGCFANT 296 Query: 345 QVLRAELAGQTTLESLLAQVRDTSFAAQAHRDIPLERLVEVLQPERSIGRTPLFQVMFNH 404 LR +L+ + LL++VR T+ A AH+D+P E+LV+VLQP RS+ +PLFQVM Sbjct: 297 LALRTDLSANPSFADLLSRVRATALGAYAHQDLPFEQLVDVLQPVRSLSHSPLFQVMLV- 355 Query: 405 LREQADGSQSWPGLSVQRLDFDAAVAQFELTLETSEEANGELSATFRYARELFDESSIAR 464 L+ G+ Q ++ D+ A+F+LT SE A G LS Y +LF ++I R Sbjct: 356 LQNLPLPELDMGGIEWQVIEADSGTAKFDLTWFVSETAQG-LSCKLEYNTDLFAATTIER 414 Query: 465 MAQHYVAILQALATQPQLRVAELQLRGAEEDRQLHSWGVNNEQHAEVMEPVHEQIARQAR 524 +A H +LQA+ P+ + EL L E +QL W Q+ + + +HE Q R Sbjct: 415 LAGHLETLLQAVVLNPEQHINELPLLTTVEQQQLAQWNATQRQYPQ--QCLHELFEAQVR 472 Query: 525 RQPEATALLFGRQQLSYGALERRANQLAHRLIRLGAGPEVKVGIAVERSLEMVIGLLGIL 584 + PE A+++G +QL+Y L +ANQLA L LG PE VGI V+RSL+M+IGLL IL Sbjct: 473 QTPEKIAVIWGEKQLTYQELNTKANQLACHLQSLGVQPETPVGICVDRSLDMIIGLLAIL 532 Query: 585 KAGAAYVPLDPEYPAQRLQYMMQDSGMRLLLTQQHVLPTLPPLAGLPVLALDQLDLDDEA 644 KA AYVPLDP YP RL ++++DS M++LLTQQ L LP L +P+++LD ++ Sbjct: 533 KADGAYVPLDPTYPEARLAFIIEDSQMQVLLTQQKQLTKLPQLQ-IPIISLDTPIPSPQS 591 Query: 645 HQPPAVRVHGENLAYVIYTSGSTGQPKGVANRHCALRNRLAWMQQAYRLEPHDTVLQKTP 704 NLAY+IYTSG+TG PKGVA H + + W ++ Y VL T Sbjct: 592 PV--PSPQSPTNLAYIIYTSGTTGIPKGVAITHQSPVTLMYWAREIYTRAELTGVLASTS 649 Query: 705 FSFDVSVWEFFWPLMIGARLALAQPGDHRDPARLVEQIQRHAVSTLHFVPSMLQAFLAHD 764 FD+S++E F PL G + LA + +L E V+ ++ VPS + L + Sbjct: 650 ICFDLSIFEIFVPLSWGGCVILAD-----NALQLPELPAAAQVTLINTVPSAARELLRLN 704 Query: 765 EIEGCSSLHRLICSGEALPVEAQQGVFARLPQVALYNLYGPTEAAIDVTHWTCRADGRSQ 824 I +++ + +GE LP ++ + +YNLYGP+E TH + + Sbjct: 705 GI--AATVQTVNLAGEPLPKSLVDELYQQSTIERVYNLYGPSEDTTYSTHALIPRNSQQA 762 Query: 825 VPIGRPISSIRTLVLDGDLNLAPQGVPGELYLGGIGLARGYLGRAGLSAERFV----ADP 880 IG+PI++ + +LD +L P G+PGE+YL G GLARGY R L+ ERF+ + Sbjct: 763 PTIGQPIANTQVYILDQNLQPVPVGIPGEIYLSGAGLARGYWKRPKLTDERFIKQSTVNS 822 Query: 881 FSADGERLYRTGDLVRWNREGQLDYLGRLDHQVKIRGLRIELGEIEARLLAQPGVREAVV 940 + LY+TGD R+ +G ++YLGR DHQVK+RG RIELGEIEA L P + +AV Sbjct: 823 QQSTVNTLYKTGDRARYLPDGNIEYLGRFDHQVKLRGFRIELGEIEALLHQHPELTQAVA 882 Query: 941 VAR-ESAGTSRLVAY-VSGTDLVAATLRSALTKDLPDYMVPALIEVLEHLPLNANGKVDR 998 + R ++ SRLVAY V + + AA LR L LP YM+P +LE LPL ANGKVDR Sbjct: 883 IVRNDTPEHSRLVAYVVPKSHIEAAELRQFLAAKLPAYMLPTAFVILETLPLTANGKVDR 942 Query: 999 RALPDPAQPLQRAYEAPRGQAEQVLAAVWAEVLGLQQVGRHDNFFELGGDSILSLQIVAG 1058 ALP P APR EQ L +W +VLG++ + HDNFF LGGDSIL++Q VA Sbjct: 943 FALPIPDLSPVTTTTAPRTPIEQQLINIWTQVLGVESISIHDNFFRLGGDSILAIQAVAK 1002 Query: 1059 LRRRGSQLAPRLIFERQTIAQLAPAIAHSTAPQLHAQVSVQGELPLLPIQAEFFAMDIPV 1118 ++G L PR +F+ QT+A+LA AI + Q + GE+PL PIQ FF ++ Sbjct: 1003 ANQQGLALRPRQMFQYQTVAELA-AIVDTDTTLSSEQTPITGEVPLTPIQQWFFEQNLVD 1061 Query: 1119 RHHWNQSILLATDAPLDMAALNTALQAVVAHHDSLRLRYTRDDQGQWRQTYGQHDPAQLR 1178 HHWNQ+ILL L+ L AL ++AHHD LR + + G WRQ D QL Sbjct: 1062 AHHWNQAILLEVHQSLNPDYLRQALDQLLAHHDGLRSHFQQTPDG-WRQFVA--DINQLH 1118 Query: 1179 E--------LLW-----VRQGLP-------------------------GNAIAPLCEQAQ 1200 LL+ ++ LP + IA + Q Sbjct: 1119 NTQKPNPQPLLYKGRGEIKASLPLGERLGEGFYYFDMSELTNLHPEKVSDTIANIANDLQ 1178 Query: 1201 RSLNLARGPLLRAVAMEL-EEGGWRLLLVIHHLVVDGVSWRILLADLQQAYRQCVALEPL 1259 S NL PLLR + E RLLL+ HHL++DG+SWR+ L DLQ AY+Q + + Sbjct: 1179 ASFNLETPPLLRLAYFDCGETQNHRLLLIFHHLIIDGISWRVFLEDLQLAYQQLSQGQQI 1238 Query: 1260 VLPARTASYQQWAHVLQGRHGA--LLPQRPYWQA---QMQPPSVLPCDDAGGEATMRQRQ 1314 LP +T SYQQWA+ LQ + L YW + Q PP LP D A G TM Sbjct: 1239 QLPPKTTSYQQWANKLQEHTWSADLQAAFNYWTSPTWQQIPP--LPVDYAPGSNTMADVD 1296 Query: 1315 EMSFGLDKERTNALLRRVPAAYRTRINDVLLTALVRALCGWSGLSEIQVDIEGHGREDGT 1374 S L T LL+ VP AYRT+INDVLLTALV A W+G + + V++EGHGRED Sbjct: 1297 TYSTFLSVTDTQNLLQEVPHAYRTQINDVLLTALVLAFQTWTGENRLLVELEGHGREDLF 1356 Query: 1375 GQLDLSRTVGWFTSVFP--LRLSGAGTPQQALKRIKESLRAVPEAGLGFGLLRQAGNLPG 1432 ++LSRT+GWFTS+FP L + + +LK IKE LR +P+ G+ +GLLR + Sbjct: 1357 PSINLSRTMGWFTSLFPVLLDIYPSADLGISLKAIKEQLRQIPDRGISYGLLRYLASPTI 1416 Query: 1433 SSSSPVI------FNYLGQFDASFDGTSGWRPAQEESGAAIDPDAPMQHEFAVEGQVYDG 1486 + I FNYLGQ D F S + PA E G + + V G Sbjct: 1417 RDTIKAIPLPQVRFNYLGQSDQIFSENSLFTPASESIGHSRSSRGKRNTLIEINSIVTGG 1476 Query: 1487 QLLINVAYSGKRYARASVQAWVERFEQELDALITHC-TSGACGATPSDFPLAGLDQTAID 1545 +L + YS + + R ++ E ++Q L +LI HC T G TPSDFP Q +D Sbjct: 1477 KLRCDWTYSKQLHHRQTIATLAENYQQILLSLIQHCLTPEVSGFTPSDFPQMDFSQDELD 1536 Query: 1546 QL 1547 +L Sbjct: 1537 KL 1538 Score = 582 bits (1500), Expect = e-165, Method: Compositional matrix adjust. Identities = 396/1076 (36%), Positives = 584/1076 (54%), Gaps = 49/1076 (4%) Query: 2602 RNGLLPASYAQARQWFLWQLDPGSSAYHINGALRLCGTLDEAALEQAFSRLLERHPSLRT 2661 R G LP S+AQ R W L QL+P S Y+I A+++ G + +L+++F+ ++ R LR+ Sbjct: 1 RTGNLPLSFAQQRFWILAQLEPDSPFYNIPLAVQIRGDIHLDSLQRSFTEVVRRQEILRS 60 Query: 2662 VLRADADGQVLQWVQPHACLAFKRIDLEPLAEGPRQARLHAEVASLCRQPFDLEAGPLLR 2721 + DGQ + + + IDL+ L E +Q ++ + +QPFDL AG L R Sbjct: 61 HF-LNVDGQPVLRIADVCDVNIPVIDLQGLPEFEQQQQVQELARTQAQQPFDL-AGLLWR 118 Query: 2722 IGLLRESGHRHVLVMVMHHIISDGWSMQLIMDEFASLY-----GACCQGREAGLPALPLQ 2776 + L++ VL++ +HHII+D WS+ L++ E + + G + RE +Q Sbjct: 119 VRLVKLGEGNQVLLLTLHHIIADAWSVGLLVREISRAFAERPAGKAQRRREEER----IQ 174 Query: 2777 YADYAAWQRQWMQGGQRETQLRYWQDHLGQSQPSLLLPADHPRRPDGLYRAARHEAVLPP 2836 Y D+A WQR+W++G E L YW+ L + L LP D+PR +R A + L Sbjct: 175 YVDFAFWQREWLRGRVLEEHLEYWRGQLESAPVMLELPTDYPRPAVQSFRGAVYGFGLSA 234 Query: 2837 PLVAALRQRVQSDGGTLFAVLLAAAQLLMYRYSGQNDIRLGVPIANRHLPDTEGVVGFFV 2896 L L+ + TLF LLA +L+YRYSG +DI +G PIANR+ +TEG++G F Sbjct: 235 ELTQGLQGLSRRYHSTLFMTLLAVWNVLLYRYSGDDDIVVGSPIANRNRVETEGLIGCFA 294 Query: 2897 NTQVLRAEIDPRQSLARLVQLTRETAQGAQQHQDLPFEQLVEVLQPQRLVGVNPLFQVMF 2956 NT LR ++ S A L+ R TA GA HQDLPFEQLV+VLQP R + +PLFQVM Sbjct: 295 NTLALRTDLSANPSFADLLSRVRATALGAYAHQDLPFEQLVDVLQPVRSLSHSPLFQVML 354 Query: 2957 NHQRHARPTSHQLPQLTLEPFELEEQDAQFELAIDTLEDTDGGLSVSLTYARELFEPQTM 3016 Q P + + + E + A+F+L + +T GLS L Y +LF T+ Sbjct: 355 VLQNLPLP-ELDMGGIEWQVIEADSGTAKFDLTW-FVSETAQGLSCKLEYNTDLFAATTI 412 Query: 3017 ATMASHYLVALEALASQPQCRVGEIDWLGPAERSRLAAWGDKVSPYATPAVITTRIAQRA 3076 +A H L+A+ P+ + E+ L E+ +LA W Y + AQ Sbjct: 413 ERLAGHLETLLQAVVLNPEQHINELPLLTTVEQQQLAQWNATQRQYPQQCLHELFEAQVR 472 Query: 3077 SIQPDAVALISGNRSMSYGQLNTRVNQLAHYLLQRGLQPEARVGVALERSADMVVAVLAI 3136 P+ +A+I G + ++Y +LNT+ NQLA +L G+QPE VG+ ++RS DM++ +LAI Sbjct: 473 QT-PEKIAVIWGEKQLTYQELNTKANQLACHLQSLGVQPETPVGICVDRSLDMIIGLLAI 531 Query: 3137 LKAGATYVPLDPDYPVQRLAAIIEDSALSLLLSQTSVSQRLPGGRAEQTLYLDQLDLQAQ 3196 LKA YVPLDP YP RLA IIEDS + +LL+Q +LP + + LD Q Sbjct: 532 LKADGAYVPLDPTYPEARLAFIIEDSQMQVLLTQQKQLTKLPQLQIP-IISLDTPIPSPQ 590 Query: 3197 PHDEPDVTIHSDSLAYVIYTSGSTGRPKGVGISHRCLMEHGQIAADFFGLTPQDCMLQFS 3256 +LAY+IYTSG+TG PKGV I+H+ + A + + +L + Sbjct: 591 SPVP--SPQSPTNLAYIIYTSGTTGIPKGVAITHQSPVTLMYWAREIYTRAELTGVLAST 648 Query: 3257 TLNFDGCIEQLFPPLLVGAAVVLRGPELWDSQRLHVELLAHRISVLDL--TTAYWLLLVQ 3314 ++ FD I ++F PL G V+L L +L A ++++++ + A LL + Sbjct: 649 SICFDLSIFEIFVPLSWGGCVILADNAL----QLPELPAAAQVTLINTVPSAARELLRLN 704 Query: 3315 DFARMGVPDYGVLRRVHVGGEAMPPEGI-KAWRDAGLAQVELFNTYGPTEATVTASILSC 3373 A ++ V++ GE +P + + ++ + + +V +N YGP+E T T S + Sbjct: 705 GIA-------ATVQTVNLAGEPLPKSLVDELYQQSTIERV--YNLYGPSEDT-TYSTHAL 754 Query: 3374 APYVSGQTVLPAQMPIGAPLAGRKLRVLDAELSPLPIGVAGELCIGGELLARGYLNQPGL 3433 P S Q P IG P+A ++ +LD L P+P+G+ GE+ + G LARGY +P L Sbjct: 755 IPRNSQQA--PT---IGQPIANTQVYILDQNLQPVPVGIPGEIYLSGAGLARGYWKRPKL 809 Query: 3434 SAERFVADPLGDGG----ARLYRTGDLVRWTHAGQLEYLGRIDHQVKIRGFRIEMGEIES 3489 + ERF+ + LY+TGD R+ G +EYLGR DHQVK+RGFRIE+GEIE+ Sbjct: 810 TDERFIKQSTVNSQQSTVNTLYKTGDRARYLPDGNIEYLGRFDHQVKLRGFRIELGEIEA 869 Query: 3490 IMLAQPEVREAVVVAREGVGS-LQLVAYVTPQHGRHIETAELRECLVRHLPDYMVPAALV 3548 ++ PE+ +AV + R +LVAYV P+ HIE AELR+ L LP YM+P A V Sbjct: 870 LLHQHPELTQAVAIVRNDTPEHSRLVAYVVPK--SHIEAAELRQFLAAKLPAYMLPTAFV 927 Query: 3549 VLPALPLNANGKVDRKALPEPVYESRTGHEPPQGECEQALAAIWAEVLGLPAVGRHDNFF 3608 +L LPL ANGKVDR ALP P T P+ EQ L IW +VLG+ ++ HDNFF Sbjct: 928 ILETLPLTANGKVDRFALPIPDLSPVTTTTAPRTPIEQQLINIWTQVLGVESISIHDNFF 987 Query: 3609 ELGGHSLSILRIQSRIQQQFPASALPLRSHFDHPTIAAFAQQL-TRSSLPSGQDEI 3663 LGG S+ ++ ++ QQ AL R F + T+A A + T ++L S Q I Sbjct: 988 RLGGDSILAIQAVAKANQQ--GLALRPRQMFQYQTVAELAAIVDTDTTLSSEQTPI 1041 Score = 422 bits (1085), Expect = e-117, Method: Compositional matrix adjust. Identities = 436/1585 (27%), Positives = 702/1585 (44%), Gaps = 161/1585 (10%) Query: 1559 PLSPMQSGMLFHSVSEPDNAAYTMQMQVALEA-LQPERFRAAWQAVLDRHAILRSAILQR 1617 PLS Q + EPD+ Y + + V + + + + ++ V+ R ILRS L Sbjct: 6 PLSFAQQRFWILAQLEPDSPFYNIPLAVQIRGDIHLDSLQRSFTEVVRRQEILRSHFLNV 65 Query: 1618 DDAPLQWVARRVVLPWQLRDCRHSPDLAAELDE--LARREREAGFDLARPPLMRLMLVST 1675 D P+ +A + + D + P+ + LAR + + FDLA L R+ LV Sbjct: 66 DGQPVLRIADVCDVNIPVIDLQGLPEFEQQQQVQELARTQAQQPFDLAGL-LWRVRLVKL 124 Query: 1676 GEQGYHLIWTVHHLLLDGWSTSQLLGEVLRHYAGQTL-------DEPVAAYGDYI----R 1724 GE L+ T+HH++ D WS L+ E+ R +A + +E Y D+ Sbjct: 125 GEGNQVLLLTLHHIIADAWSVGLLVREISRAFAERPAGKAQRRREEERIQYVDFAFWQRE 184 Query: 1725 WLQGRDQQASRHHWQSLLHRLQEPSLLVARLP-----PAKQPNRARDYRQYTCCLGQAQT 1779 WL+GR + +W+ L E + ++ LP PA Q R Y L T Sbjct: 185 WLRGRVLEEHLEYWRGQL----ESAPVMLELPTDYPRPAVQSFRGA---VYGFGLSAELT 237 Query: 1780 RRLVEFARARHLTLSTLVQAAWALLLQRYAGHGTVCFGATTAGRPMDLAGAESMLGLFIN 1839 + L +R H TL + A W +LL RY+G + G+ A R + E ++G F N Sbjct: 238 QGLQGLSRRYHSTLFMTLLAVWNVLLYRYSGDDDIVVGSPIANR--NRVETEGLIGCFAN 295 Query: 1840 TLPVVTTLTPQTALDEWLQQLQRQSAQSREHEYTPLYEI----QRLAGHSGQSLFDTVVV 1895 TL + T L+ + + L +++ + + H+ P ++ Q + S LF ++V Sbjct: 296 TLALRTDLSANPSFADLLSRVRATALGAYAHQDLPFEQLVDVLQPVRSLSHSPLFQVMLV 355 Query: 1896 FENYPV---DAALHSQEVDKLVVGEVRFSSGNHYPLTLRVS-LAEQLQIDFLHDTGMIAP 1951 +N P+ D +V + G +F LT VS A+ L ++T + A Sbjct: 356 LQNLPLPELDMGGIEWQVIEADSGTAKFD------LTWFVSETAQGLSCKLEYNTDLFAA 409 Query: 1952 ELLARMAAQFTSLLEQFSQDDGE----------TRRRRLADLSLTDLPAPLQGPTIRADD 2001 + R+A +LL+ + + +++LA + T P Q Sbjct: 410 TTIERLAGHLETLLQAVVLNPEQHINELPLLTTVEQQQLAQWNATQRQYPQQC------- 462 Query: 2002 VIERWAAQVSQQPGAAALTDGNHALDMAGLCAWVEQMAQQMRQRGIGCEDRVAIHAERSC 2061 + E + AQV Q P A+ G L L Q+A ++ G+ E V I +RS Sbjct: 463 LHELFEAQVRQTPEKIAVIWGEKQLTYQELNTKANQLACHLQSLGVQPETPVGICVDRSL 522 Query: 2062 AFVVAVLATLRVGAAYVPLDPALPAERLHYQLQDSAAVLLLSATAPDWAASVPVL--PLA 2119 ++ +LA L+ AYVPLDP P RL + ++DS +LL T +P L P+ Sbjct: 523 DMIIGLLAILKADGAYVPLDPTYPEARLAFIIEDSQMQVLL--TQQKQLTKLPQLQIPII 580 Query: 2120 SLHGVPKRVPYCWPAVHP-GQAAYVIYTSGSTGRPKGVVVSRGALANYVAGVLERLDLRE 2178 SL P+ AY+IYTSG+TG PKGV ++ + + E + R Sbjct: 581 SLDTPIPSPQSPVPSPQSPTNLAYIIYTSGTTGIPKGVAITHQSPVTLMYWARE-IYTRA 639 Query: 2179 QDRSMAMVSTVGADLGHTVLFGALCSGRLLHLIPPQCSFDPDAMASYMEQHQVDVLKIVP 2238 + + +++ DL +F L G + L P+ A+ QV ++ VP Sbjct: 640 ELTGVLASTSICFDLSIFEIFVPLSWGGCVILADNALQL-PELPAA----AQVTLINTVP 694 Query: 2239 SHLQALLHAASPASVLPRSRLVLGGEASRKPLLAHIASLRPQCRVMNHYGPTETTVGVLT 2298 S + LL A+ + + L GE K L+ + RV N YGP+E T + Sbjct: 695 SAARELLRLNGIAATV--QTVNLAGEPLPKSLVDELYQQSTIERVYNLYGPSEDTT--YS 750 Query: 2299 QEASSALDEADSLPIGQPIAQARAYVLDAELQPVPQGVAGELYLAGHGVARAYQQRPAQS 2358 A + + IGQPIA + Y+LD LQPVP G+ GE+YL+G G+AR Y +RP + Sbjct: 751 THALIPRNSQQAPTIGQPIANTQVYILDQNLQPVPVGIPGEIYLSGAGLARGYWKRPKLT 810 Query: 2359 AERFVADLLEPGQR-----MYRSGDRVRQLADGSLEFLGRLDGQIKVRGYRVELREIAAL 2413 ERF+ Q+ +Y++GDR R L DG++E+LGR D Q+K+RG+R+EL EI AL Sbjct: 811 DERFIKQSTVNSQQSTVNTLYKTGDRARYLPDGNIEYLGRFDHQVKLRGFRIELGEIEAL 870 Query: 2414 LQSLEAVAQAEVVVHSEPAQPGPDGEEVAPQIIAYLVPMGGQTLDVADLRQQLATRLPDY 2473 L + QA +V ++ + +++AY+VP ++ A+LRQ LA +LP Y Sbjct: 871 LHQHPELTQAVAIVRNDTPEHS--------RLVAYVVPKSH--IEAAELRQFLAAKLPAY 920 Query: 2474 MMPTALVPLHVMPLTPNGKLDRQALPRPDSTATSVYEAARGPLEETLAGLWAELLGLPQV 2533 M+PTA V L +PLT NGK+DR ALP PD + + A R P+E+ L +W ++LG+ + Sbjct: 921 MLPTAFVILETLPLTANGKVDRFALPIPDLSPVTTTTAPRTPIEQQLINIWTQVLGVESI 980 Query: 2534 GRNDDFFALGGDSILVLKLVARARKRDVKLAPKMLFEGKTPAGVAQLL---TAGSGAAGG 2590 +D+FF LGGDSIL ++ VA+A ++ + L P+ +F+ +T A +A ++ T S Sbjct: 981 SIHDNFFRLGGDSILAIQAVAKANQQGLALRPRQMFQYQTVAELAAIVDTDTTLSSEQTP 1040 Query: 2591 VERIMPLPPAQRNGLLPASYAQARQWFLWQLDPGSSAYHINGA--LRLCGTLDEAALEQA 2648 + +PL P Q QWF Q A+H N A L + +L+ L QA Sbjct: 1041 ITGEVPLTPIQ-------------QWFFEQ--NLVDAHHWNQAILLEVHQSLNPDYLRQA 1085 Query: 2649 FSRLLERHPSLRTVLRADADG-----------QVLQWVQPHACLAFKRIDL-------EP 2690 +LL H LR+ + DG Q P L R ++ E Sbjct: 1086 LDQLLAHHDGLRSHFQQTPDGWRQFVADINQLHNTQKPNPQPLLYKGRGEIKASLPLGER 1145 Query: 2691 LAEG------PRQARLH--------AEVASLCRQPFDLEAGPLLRIGLLR-ESGHRHVLV 2735 L EG LH A +A+ + F+LE PLLR+ H L+ Sbjct: 1146 LGEGFYYFDMSELTNLHPEKVSDTIANIANDLQASFNLETPPLLRLAYFDCGETQNHRLL 1205 Query: 2736 MVMHHIISDGWSMQLIMDEFASLYGACCQGREAGLPALPLQYADYAAWQRQWMQGGQRET 2795 ++ HH+I DG S ++ +++ Y QG++ LP Y +A ++ + Sbjct: 1206 LIFHHLIIDGISWRVFLEDLQLAYQQLSQGQQIQLPPKTTSYQQWANKLQEHTWSADLQA 1265 Query: 2796 QLRYWQDHLGQSQPSLLLPADHPRRPDGLYRAARHEAVLPPPLVAALRQRVQSDGGT-LF 2854 YW Q P LP D+ + + + L L Q V T + Sbjct: 1266 AFNYWTSPTWQQIPP--LPVDYAPGSNTMADVDTYSTFLSVTDTQNLLQEVPHAYRTQIN 1323 Query: 2855 AVLLAAAQLLMYRYSGQNDIRLGVPIANRH--LP--DTEGVVGFFVNTQVLRAEIDPRQS 2910 VLL A L ++G+N + + + R P + +G+F + + +I P Sbjct: 1324 DVLLTALVLAFQTWTGENRLLVELEGHGREDLFPSINLSRTMGWFTSLFPVLLDIYPSAD 1383 Query: 2911 LARLVQLTRETAQGAQQHQDLPFEQLVEVLQP--QRLVGVNPLFQVMFNHQRHARPTSHQ 2968 L ++ +E + + + + L + P + + PL QV FN+ + + Sbjct: 1384 LGISLKAIKEQLRQIPD-RGISYGLLRYLASPTIRDTIKAIPLPQVRFNYLGQSDQIFSE 1442 Query: 2969 LPQLTLEPFELEEQDA-----QFELAIDTLEDTDGGLSVSLTYARELFEPQTMATMASHY 3023 T + + + I+++ T G L TY+++L QT+AT+A +Y Sbjct: 1443 NSLFTPASESIGHSRSSRGKRNTLIEINSIV-TGGKLRCDWTYSKQLHHRQTIATLAENY 1501 Query: 3024 LVALEALASQPQCRVGEIDWLGPAE 3048 L +L C E+ P++ Sbjct: 1502 QQILLSLIQ--HCLTPEVSGFTPSD 1524