BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.2223.p (1789 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PA2400 [Q] COG1020 Non-ribosomal peptide synthetase modules and ... 776 0.0 PA2399_2 [Q] COG1020 Non-ribosomal peptide synthetase modules an... 724 0.0 PA2399_1 [Q] COG1020 Non-ribosomal peptide synthetase modules an... 721 0.0 PA2402_1 [Q] COG1020 Non-ribosomal peptide synthetase modules an... 712 0.0 PA2424_3 [Q] COG1020 Non-ribosomal peptide synthetase modules an... 706 0.0 >PA2400 [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins Pae Pseudomonas aeruginosa Length = 1317 Score = 776 bits (2003), Expect = 0.0, Method: Compositional matrix adjust. Identities = 538/1347 (39%), Positives = 723/1347 (53%), Gaps = 96/1347 (7%) Query: 440 RTGDLGFW-ADGELFVAGRLKDMIIVRGHNIYPQDLEQALEAEVEALRKGRIAVFAVSLD 498 RTGDL DG + GR + +RG I ++E L ++E +R+ A++LD Sbjct: 20 RTGDLARRRGDGVIEYMGRADHQVKIRGFRIELGEVEARL-LDLEGIREAA----ALALD 74 Query: 499 TEEGVGVAVEVSRGMQKLVAPQALCEAVATVVQRQCGE--APQVLVLLNPGGLPKTSSGK 556 G VA V+ G + AL E + T ++ + P L+ L +P + +GK Sbjct: 75 ---GQLVAYLVAEGGEDETRQPALRERIRTALRASLPDYMVPSHLLFLE--RMPLSPNGK 129 Query: 557 LQRGACRTGWHQGSLDAYAVFEQGRMVQGSQSTTMATVPPVAAQRAGEPEVRAALALLWQ 616 L R A + G M + + A VAA +W Sbjct: 130 LDRRALPKP------------DAGLMQRDHMAPASALEKDVAA--------------IWG 163 Query: 617 EVLMPGVAGEPSADAHFLACGGNSLAAVQLAARISQHWQIAFAASQVFEYPRLQQQAALI 676 E+L GV D +F GG+SL A +L +RI Q I + +FE P + Sbjct: 164 ELL--GVERVGLTD-NFFELGGHSLLATRLVSRIRQDLGIEVSLKSLFEQP--------V 212 Query: 677 LDALEDGKGGTATGIARLSEAQRRTPQPLSSAQQRQWFLWQLAPQSTAYHVQGALRLGGP 736 L + G + ++ R P PLS AQ+RQWFLWQL P+S AYH+ ALRL G Sbjct: 213 LQGFVESLGEKPAEVPPITPVTREQPLPLSYAQERQWFLWQLEPESAAYHIPAALRLRGG 272 Query: 737 LDVFALQRAFNALMRRHEVLQTVFRSTDQGQLEQVVGTQPVAELELVEADTGPNGALSLP 796 LDV ALQR+F L +RHE L+T FR Q L V +L++ + SL Sbjct: 273 LDVVALQRSFERLAQRHESLRTRFR---QEGLRTVQVVDADGQLQVSRHNLANVDDASLR 329 Query: 797 AALDLLQQRHGQPFDLTHGPLVRACLLALDDGSHVLGMVMHHIISDGASMHLLIEELAQL 856 AA++ R PFDL L+R L + HVL MV HHI+SDG SM L++EEL QL Sbjct: 330 AAVEAEMAR---PFDLRTDALLRISLFEVAPNDHVLVMVQHHIVSDGWSMQLMVEELVQL 386 Query: 857 YAELHAGRQSALAPAILHYVDYIAWQQARADDPEHRVALDYWTRELAVPAGQAQPVLALP 916 YA GR++AL + Y DY WQ+ + E L YW L G QPVL LP Sbjct: 387 YAAYSQGREAALPALPIQYPDYAVWQREWMEAGERERQLAYWIGLL----GGEQPVLELP 442 Query: 917 VDRARPVLARYHASHHHFALPDDLLAGLRGQARQAGMTLFALLLSGLQALLHRYTGQQDI 976 DR RP + + F L + L+ A++ G + F LLL+ QALL+RY+GQ DI Sbjct: 443 FDRPRPAEQSFRGARLEFELGAERARRLKALAQRQGASTFMLLLASFQALLYRYSGQSDI 502 Query: 977 RVGVPVANRSHPDLLGVVGFFVNTLVLRAPFDEDITLAQLLAQTAQRTLLAQRHQGLPFE 1036 RVGVPVANR+ + ++GFFVNT VL+A D + +LL Q QR+L AQ HQ LPFE Sbjct: 503 RVGVPVANRNRVETERLIGFFVNTQVLKADIDGQMGFDRLLHQVRQRSLEAQAHQDLPFE 562 Query: 1037 QLVEVLQPERSLTHSALFQVMFNHLPQHYAASAQGLGDV----VEELFLPDREAQFELTL 1092 QLVE LQPERSL+HS LFQV+FN+ + GL +V +EE AQF+L L Sbjct: 563 QLVEALQPERSLSHSPLFQVLFNYQAER---GEHGLPEVAGLSIEEQAWESHTAQFDLVL 619 Query: 1093 DTREHPDGRVSAVLTYAKELFDPQRIAQLAQSYLAILRALVDEPQQLVAEVALLSPAQQA 1152 DT E + + A L YA +LFD +L + + +L A++ P + E+ +L ++ Sbjct: 620 DTCES-ESDIWAALVYATDLFDASTAERLVRHWQNLLDAILAMPDARLGELDMLDREERE 678 Query: 1153 QLQQ-WGCNPQRYPLDPPIHVRIAQQARRTPEAIALVLDRQQLSYAQLEARANQMARQLL 1211 + Q W + YP P +H R+A++AR P+A+A++ D ++L+YA+L+ RAN++A L+ Sbjct: 679 VIGQLWNRSDSGYPATPLVHQRVAERARMAPDAVAVIFDEEKLTYAELDNRANRLAHALI 738 Query: 1212 AMGVQPEQRIGLALERSLDMVPALLAILKAGACFVPLDPQYPRARLTAMIEDSRIRLALT 1271 A GV PE R+ +A++RS +++ A LA+LKAG +VPLD +YPR RL M++DSR L LT Sbjct: 739 ARGVGPEVRVAIAMQRSAEIMVAFLAVLKAGGAYVPLDIEYPRERLLYMMQDSRAHLLLT 798 Query: 1272 QSHMREHLPGQAGVRWLELDRLPAPAATSDFMEAPDVITHPAQLAYVIYTSGSTGRPKGV 1331 SH+ E LP G+ L +DR A P+V H LAYVIYTSGSTG PKGV Sbjct: 799 HSHLLERLPIPEGLSCLSVDREEEWAGFP--AHDPEVALHGDNLAYVIYTSGSTGMPKGV 856 Query: 1332 AVSHGALVEHTQLSAEFSRLRNDDRMLQFATLNFDGFIEQLFPPLLVGASVVLRGPQLWS 1391 AVSHG L+ H + E + +D L F + FDG E PL+ GA V++R LW Sbjct: 857 AVSHGPLIAHIVATGERYEMTPEDCELHFMSFAFDGSHEGWMHPLINGARVLIRDDSLWL 916 Query: 1392 PEEFQQRLREHDISIADLPTAYWHALIQSFARQGQSDYGRLREIHIGGEAMPAESIA-TW 1450 PE + H +++ P Y L + R G +R GG+A+ S W Sbjct: 917 PERTYAEMHRHGVTVGVFPPVYLQQLAEHAERDGNPP--PVRVYCFGGDAVAQASYDLAW 974 Query: 1451 RQAGLSAVRLLNTYGPTEAVVVASLLDCDPFVQGQREVPTQMPIGQPLAGRSLHVLDERL 1510 R L L N YGPTE VV L G MPIG L RS ++LD +L Sbjct: 975 R--ALKPKYLFNGYGPTETVVTPLLWKAR---AGDACGAAYMPIGTLLGNRSGYILDGQL 1029 Query: 1511 QALPAGVPGELYIGGDLLARGYLERPGLTAERFVADPGSEAGGRLYRTGDLVCWNAQSEL 1570 LP GV GELY+GG+ +ARGYLERP LTAERFV DP G RLYR+GDL A + Sbjct: 1030 NLLPVGVAGELYLGGEGVARGYLERPALTAERFVPDPFGAPGSRLYRSGDLTRGRADGVV 1089 Query: 1571 HYLGRSDLQVKLRGFRVELGEIEAQLLAQPEVRQAIVVAHQA----RLVGY--------A 1618 YLGR D QVK+RGFR+ELGEIEA+L P VR+A+VVA +LVGY A Sbjct: 1090 DYLGRVDHQVKIRGFRIELGEIEARLREHPAVREAVVVAQPGAVGQQLVGYVVAQEPAVA 1149 Query: 1619 SLYPGQELSTAQLRERLRASLPDYMVPATVIVLEQLPTNPNGKIDRHALPAP-ADVIAVG 1677 Q AQL+ LR LP+YMVP+ ++ L ++P PNGK+DR LP P A ++ Sbjct: 1150 DSPEAQAECRAQLKTALRERLPEYMVPSHLLFLARMPLTPNGKLDRKGLPQPDASLLQQV 1209 Query: 1678 GLAPVGQLEEQLGGIWRELLRLEQVGRDDNFFELGGHSLLLLVAHERIKALSLACVPSVV 1737 +AP LE+Q+ GIW E+L+L+QVG DDNFFELGGHSLL R++ VP + Sbjct: 1210 YVAPRSDLEQQVAGIWAEVLQLQQVGLDDNFFELGGHSLLATQVIGRLRERLHLEVP-IK 1268 Query: 1738 DLFRYPTIATLAAFLDGAAPTRNDAGP 1764 +F T TL F G + ++ P Sbjct: 1269 SMF---TAETLGEFCHGVETLKAESAP 1292 Score = 179 bits (454), Expect = 5e-44, Method: Compositional matrix adjust. Identities = 104/214 (48%), Positives = 135/214 (63%), Gaps = 7/214 (3%) Query: 1538 LTAERFVADPGSEAGGRLYRTGDLVCWNAQSELHYLGRSDLQVKLRGFRVELGEIEAQLL 1597 +TAERF+ DP E G RLYRTGDL + Y+GR+D QVK+RGFR+ELGE+EA+LL Sbjct: 1 MTAERFLPDPFGEPGSRLYRTGDLARRRGDGVIEYMGRADHQVKIRGFRIELGEVEARLL 60 Query: 1598 AQPEVRQAIVVAHQARLVGYASLYPGQ-ELSTAQLRER----LRASLPDYMVPATVIVLE 1652 +R+A +A +LV Y G+ E LRER LRASLPDYMVP+ ++ LE Sbjct: 61 DLEGIREAAALALDGQLVAYLVAEGGEDETRQPALRERIRTALRASLPDYMVPSHLLFLE 120 Query: 1653 QLPTNPNGKIDRHALPAP-ADVIAVGGLAPVGQLEEQLGGIWRELLRLEQVGRDDNFFEL 1711 ++P +PNGK+DR ALP P A ++ +AP LE+ + IW ELL +E+VG DNFFEL Sbjct: 121 RMPLSPNGKLDRRALPKPDAGLMQRDHMAPASALEKDVAAIWGELLGVERVGLTDNFFEL 180 Query: 1712 GGHSLLLLVAHERIKALSLACVPSVVDLFRYPTI 1745 GGHSLL RI+ L S+ LF P + Sbjct: 181 GGHSLLATRLVSRIRQ-DLGIEVSLKSLFEQPVL 213 Score = 62.4 bits (150), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 162/663 (24%), Positives = 250/663 (37%), Gaps = 110/663 (16%) Query: 25 LARERPDDTALIVVQAVAGVDQERRFSYQVLAQRVRALAAVLQAR-LGRGERALILLDND 83 L +R + A + AVA + E + +Y L R LA L AR +G R I + Sbjct: 696 LVHQRVAERARMAPDAVAVIFDEEKLTYAELDNRANRLAHALIARGVGPEVRVAIAMQRS 755 Query: 84 EYYAISMFACFYAGVIAVPV---FPPESASAAHTGRLAGIAADAGARGLLILDANRALVA 140 ++ A AG VP+ +P E RL + D+ A LL + Sbjct: 756 AEIMVAFLAVLKAGGAYVPLDIEYPRE--------RLLYMMQDSRAHLLLTHSHLLERLP 807 Query: 141 ACEGLQQAEMIAVDQIGAGDRGPWQA-AAPDPQ------EIAFLQYTSGSTSAPKGVMVT 193 EGL ++VD+ W A DP+ +A++ YTSGST PKGV V+ Sbjct: 808 IPEGLS---CLSVDR-----EEEWAGFPAHDPEVALHGDNLAYVIYTSGSTGMPKGVAVS 859 Query: 194 HAALMANEAAIREGLSIGEGDSFCVWSPLFHDMGLIGGLLQPFYSGIVCVLCSPRYFLER 253 H L+A+ A E + D + D G G + P +G ++ +L Sbjct: 860 HGPLIAHIVATGERYEMTPEDCELHFMSFAFD-GSHEGWMHPLINGARVLIRDDSLWL-- 916 Query: 254 PVRWLQMIARHRVSISGGPDFAYRLCLDRIKDRQLEGLDLSCWRVAYTGAEPVRHQTMEA 313 P R + RH V++ P + L ++ + + RV G + V + + Sbjct: 917 PERTYAEMHRHGVTVGVFPP----VYLQQLAEHAERDGNPPPVRVYCFGGDAVAQASYD- 971 Query: 314 FVQRFASVGLDPAAVYPCYGLAEA--TLFVTGGRRGAGLRVQRYLPHA--LRSRLALPAD 369 A L P ++ YG E T + R G Y+P L +R D Sbjct: 972 ----LAWRALKPKYLFNGYGPTETVVTPLLWKARAGDACGAA-YMPIGTLLGNRSGYILD 1026 Query: 370 AEEPAVALVACGRAPSQHQVRIAADASGAPAAPGGIGEIWVTGPSIARGYWKQALQSAQT 429 + + L+ G A GE+++ G +ARGY ++ +A+ Sbjct: 1027 GQ---LNLLPVGVA----------------------GELYLGGEGVARGYLERPALTAER 1061 Query: 430 FVE----LENQTWLRTGDLGFW-ADGELFVAGRLKDMIIVRGHNIYPQDLEQALEAEVEA 484 FV R+GDL ADG + GR+ + +RG I ++E L E A Sbjct: 1062 FVPDPFGAPGSRLYRSGDLTRGRADGVVDYLGRVDHQVKIRGFRIELGEIEARLR-EHPA 1120 Query: 485 LRKGRIAVFAVSLDTEEGVGVAVEVSRGMQKLVAPQALCEAVATVVQRQCGEAPQVLV-- 542 +R+ + V ++ VG V + QA C A R+ P+ +V Sbjct: 1121 VREA-VVVAQPGAVGQQLVGYVVAQEPAVADSPEAQAECRAQLKTALRE--RLPEYMVPS 1177 Query: 543 -LLNPGGLPKTSSGKLQRGACRTGWHQGSLDAYAVFEQGRMVQGSQSTTMATVPPVAAQR 601 LL +P T +GKL R G Q DA + Q +A + Q Sbjct: 1178 HLLFLARMPLTPNGKLD----RKGLPQP--DASLL----------QQVYVAPRSDLEQQV 1221 Query: 602 AGEPEVRAALALLWQEVLMPGVAGEPSADAHFLACGGNSLAAVQLAARISQHWQIAFAAS 661 AG +W EVL G D +F GG+SL A Q+ R+ + + Sbjct: 1222 AG----------IWAEVLQLQQVG---LDDNFFELGGHSLLATQVIGRLRERLHLEVPIK 1268 Query: 662 QVF 664 +F Sbjct: 1269 SMF 1271 >PA2399_2 [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins Pae Pseudomonas aeruginosa Length = 1060 Score = 724 bits (1869), Expect = 0.0, Method: Compositional matrix adjust. Identities = 467/1073 (43%), Positives = 631/1073 (58%), Gaps = 43/1073 (4%) Query: 702 PQPLSSAQQRQWFLWQLAPQSTAYHVQGALRLGGPLDVFALQRAFNALMRRHEVLQTVFR 761 P LS AQ+RQWFLWQL P+S AYH+ ALRL G LDV ALQR+F++L+ RHE L+T FR Sbjct: 3 PLALSFAQERQWFLWQLEPESAAYHIPSALRLRGRLDVDALQRSFDSLVARHETLRTRFR 62 Query: 762 STDQGQLEQVVGTQPVAELELVEADTGPNGALSLPAALDLLQQRHGQPFDLTHGPLVRAC 821 +QV QP + + G G + A+ + QPFDL GPL+R Sbjct: 63 LEGGRSYQQV---QPAVSVSIEREQFGEEGLIERIQAIVV------QPFDLERGPLLRVN 113 Query: 822 LLALDDGSHVLGMVMHHIISDGASMHLLIEELAQLYAELHAGRQSALAPAILHYVDYIAW 881 LL L + HVL +V HHI+SDG SM +++EEL QLYA G L + Y DY W Sbjct: 114 LLQLAEDDHVLVLVQHHIVSDGWSMQVMVEELVQLYAAYSQGLDVVLPALPIQYADYALW 173 Query: 882 QQARADDPEHRVALDYWTRELAVPAGQAQPVLALPVDRARPVLARYHASHHHFALPDDLL 941 Q++ + E L YWT L G QPVL LP DR RP + + F L +L+ Sbjct: 174 QRSWMEAGEKERQLAYWTGLL----GGEQPVLELPFDRPRPARQSHRGAQLGFELSRELV 229 Query: 942 AGLRGQARQAGMTLFALLLSGLQALLHRYTGQQDIRVGVPVANRSHPDLLGVVGFFVNTL 1001 +R A++ G + F LLL+ QALL+RY+GQ DIRVGVP+ANR+ + ++GFFVNT Sbjct: 230 EAVRALAQREGASSFMLLLASFQALLYRYSGQADIRVGVPIANRNRVETERLIGFFVNTQ 289 Query: 1002 VLRAPFDEDITLAQLLAQTAQRTLLAQRHQGLPFEQLVEVLQPERSLTHSALFQVMFNHL 1061 VL+A D + +LLAQ QR L AQ HQ LPFEQLVE LQPER+ +H+ LFQV+FNH Sbjct: 290 VLKADLDGRMGFDELLAQARQRALEAQAHQDLPFEQLVEALQPERNASHNPLFQVLFNHQ 349 Query: 1062 PQHYAASAQ-GLGDV-VEELFLPDREAQFELTLDTREHPDGRVSAVLTYAKELFDPQRIA 1119 + + + + L D+ +E L + AQF+LTLD +E +G + A YA +LFD + Sbjct: 350 SEIRSVTPEVQLEDLRLEGLAWDGQTAQFDLTLDIQEDENG-IWASFDYATDLFDASTVE 408 Query: 1120 QLAQSYLAILRALVDEPQQLVAEVALL-SPAQQAQLQQWGCNPQRYPLDPPIHVRIAQQA 1178 +LA + +LR +V P+Q + E+ LL +P ++ L +W + + + R +QA Sbjct: 409 RLAGHWRNLLRGIVANPRQRLGELPLLDAPERRQTLSEWNPAQRECAVQGTLQQRFEEQA 468 Query: 1179 RRTPEAIALVLDRQQLSYAQLEARANQMARQLLAMGVQPEQRIGLALERSLDMVPALLAI 1238 R+ P+A+AL+LD Q+LSY +L ARAN++A L+A GV + +GLALERSLDM+ LLAI Sbjct: 469 RQRPQAVALILDEQRLSYGELNARANRLAHCLIARGVGADVPVGLALERSLDMLVGLLAI 528 Query: 1239 LKAGACFVPLDPQYPRARLTAMIEDSRIRLALTQSHMREHLPGQAGVRWLELDRLPAPAA 1298 LKAG ++PLDP P RL +++DS +RL LTQ H+ E LP QAGV L +D L Sbjct: 529 LKAGGAYLPLDPAAPEERLAHILDDSGVRLLLTQGHLLERLPRQAGVEVLAIDGL----V 584 Query: 1299 TSDFMEAPDVITHPA-QLAYVIYTSGSTGRPKGVAVSH-GALVEHTQLSAEFSRLRNDDR 1356 + E+ + T A LAYVIYTSGSTG+PKG ++H AL + A F D Sbjct: 585 LDGYAESDPLPTLSADNLAYVIYTSGSTGKPKGTLLTHRNALRLFSATEAWFGFDERDVW 644 Query: 1357 MLQFATLNFDGFIEQLFPPLLVGASVVLRGPQLW---SPEEFQQRL-REHDISIADLPTA 1412 L F + FD + ++F LL G +V+ PQ W SPE+F + L RE + P+A Sbjct: 645 TL-FHSYAFDFSVWEIFGALLYGGRLVIV-PQ-WVSRSPEDFYRLLCREGVTVLNQTPSA 701 Query: 1413 YWHALIQSFARQGQSDYGRLREIHIGGEAMPAESIATWRQA-GLSAVRLLNTYGPTEAVV 1471 + + + + + LR + GGEA+ +S+ W Q G +L+N YG TE V Sbjct: 702 FKQLMAVACSADMATQQPALRYVIFGGEALDLQSLRPWFQRFGDRQPQLVNMYGITETTV 761 Query: 1472 VASLLDCDPFVQGQREVPTQMPIGQPLAGRSLHVLDERLQALPAGVPGELYIGGDLLARG 1531 + P + + PIG + S ++LD L +P G GELYIG LARG Sbjct: 762 HVT---YRPVSEADLKGGLVSPIGGTIPDLSWYILDRDLNPVPRGAVGELYIGRAGLARG 818 Query: 1532 YLERPGLTAERFVADPG-SEAGGRLYRTGDLVCWNAQSELHYLGRSDLQVKLRGFRVELG 1590 YL RPGL+A RFV +P AG RLYRTGDL + A + Y+GR D QVK+RGFR+ELG Sbjct: 819 YLRRPGLSATRFVPNPFPGGAGERLYRTGDLARFQADGNIEYIGRIDHQVKVRGFRIELG 878 Query: 1591 EIEAQLLAQPEVRQAIVVAHQ----ARLVGY--ASLYPGQELSTAQLRERLRASLPDYMV 1644 EIEA L VR A+V+AH +LVGY A E LRE L+ LPDYMV Sbjct: 879 EIEAALAGLAGVRDAVVLAHDGVGGTQLVGYVVADSAEDAERLRESLRESLKRHLPDYMV 938 Query: 1645 PATVIVLEQLPTNPNGKIDRHALPAP-ADVIAVGGLAPVGQLEEQLGGIWRELLRLEQVG 1703 PA +++LE++P NGK+DR ALP P A + AP +LE+++ IW E+L +E+VG Sbjct: 939 PAHLMLLERMPLTVNGKLDRQALPQPDASLSQQAYRAPGSELEQRIAAIWAEILGVERVG 998 Query: 1704 RDDNFFELGGHSLLLLVAHERIKALSLACVPSVVDLFRYPTIATLAAFLDGAA 1756 DDNFFELGGHSLLLL+ ERI A + S+ L + ++A AA ++G A Sbjct: 999 LDDNFFELGGHSLLLLMLKERIGDTCQATL-SISQLMTHASVAEQAACIEGQA 1050 Score = 108 bits (269), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 175/685 (25%), Positives = 269/685 (39%), Gaps = 128/685 (18%) Query: 20 ERLEQLARERPDDTALIVVQAVAGVDQERRFSYQVLAQRVRALAAVLQAR-LGRGERALI 78 +R E+ AR+RP QAVA + E+R SY L R LA L AR +G + Sbjct: 462 QRFEEQARQRP--------QAVALILDEQRLSYGELNARANRLAHCLIARGVGADVPVGL 513 Query: 79 LLDNDEYYAISMFACFYAGVIAVPVFPPESASAAHTGRLAGIAADAGARGLLILDANRAL 138 L+ + + A AG +P+ P AA RLA I D+G R LL L Sbjct: 514 ALERSLDMLVGLLAILKAGGAYLPLDP-----AAPEERLAHILDDSGVRLLL---TQGHL 565 Query: 139 VAACEGLQQAEMIAVDQI---GAGDRGPWQAAAPDPQEIAFLQYTSGSTSAPKGVMVTHA 195 + E++A+D + G + P + D +A++ YTSGST PKG ++TH Sbjct: 566 LERLPRQAGVEVLAIDGLVLDGYAESDPLPTLSAD--NLAYVIYTSGSTGKPKGTLLTHR 623 Query: 196 ALMANEAAIREGLSIGEGDSFCVWSPLFHDMGLIGGLLQPF----YSGIVCVLCSPRYFL 251 + +A E D VW+ LFH + + F Y G + ++ P++ Sbjct: 624 NALRLFSATEAWFGFDERD---VWT-LFHSYAFDFSVWEIFGALLYGGRLVIV--PQWVS 677 Query: 252 ERPVRWLQMIARHRVSISGGPDFAYR-----LCLDRIKDRQLEGLDLSCWRVAYTGAEPV 306 P + +++ R V++ A++ C + +Q R G E + Sbjct: 678 RSPEDFYRLLCREGVTVLNQTPSAFKQLMAVACSADMATQQ------PALRYVIFGGEAL 731 Query: 307 RHQTMEAFVQRFASVGLDPAAVYPCYGLAEATLFVTGGRRGAGLRVQRYLPHA---LRSR 363 Q++ + QRF G + YG+ E T+ VT Y P + L+ Sbjct: 732 DLQSLRPWFQRF---GDRQPQLVNMYGITETTVHVT------------YRPVSEADLKGG 776 Query: 364 LALPADAEEPAVALVACGRAPSQHQVRIAADASGAPAAPGGIGEIWVTGPSIARGYWKQA 423 L P P ++ R + P G +GE+++ +ARGY ++ Sbjct: 777 LVSPIGGTIPDLSWYILDRDLN-------------PVPRGAVGELYIGRAGLARGYLRRP 823 Query: 424 LQSAQTFVEL-----ENQTWLRTGDLG-FWADGELFVAGRLKDMIIVRGHNIYPQDLEQA 477 SA FV + RTGDL F ADG + GR+ + VRG I Sbjct: 824 GLSATRFVPNPFPGGAGERLYRTGDLARFQADGNIEYIGRIDHQVKVRGFRIEL------ 877 Query: 478 LEAEVEALRKGRIAVFAVSLDTEEGVG----VAVEVSRGMQKLVAPQALCEAVATVVQRQ 533 E+EA G V + +GVG V V+ + + L E++ ++R Sbjct: 878 --GEIEAALAGLAGVRDAVVLAHDGVGGTQLVGYVVADSAED---AERLRESLRESLKRH 932 Query: 534 CGE--APQVLVLLNPGGLPKTSSGKLQRGACRTGWHQGSLDAYAVFEQGRMVQGSQSTTM 591 + P L+LL +P T +GKL R A S AY Sbjct: 933 LPDYMVPAHLMLLER--MPLTVNGKLDRQALPQPDASLSQQAY----------------- 973 Query: 592 ATVPPVAAQRAGEPEVRAALALLWQEVLMPGVAGEPSADAHFLACGGNSLAAVQLAARIS 651 RA E+ +A +W E+L G D +F GG+SL + L RI Sbjct: 974 ---------RAPGSELEQRIAAIWAEILGVERVG---LDDNFFELGGHSLLLLMLKERIG 1021 Query: 652 QHWQIAFAASQVFEYPRLQQQAALI 676 Q + SQ+ + + +QAA I Sbjct: 1022 DTCQATLSISQLMTHASVAEQAACI 1046 >PA2399_1 [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins Pae Pseudomonas aeruginosa Length = 1105 Score = 721 bits (1860), Expect = 0.0, Method: Compositional matrix adjust. Identities = 471/1086 (43%), Positives = 626/1086 (57%), Gaps = 50/1086 (4%) Query: 691 IARLSEAQRRTPQPLSSAQQRQWFLWQLAPQSTAYHVQGALRLGGPLDVFALQRAFNALM 750 IA + + Q P LS AQ+RQWFLWQL P+S AYH+ LRL G LD+ ALQR+F++L+ Sbjct: 33 IAPVFKRQDGEPLRLSYAQERQWFLWQLEPESAAYHIPSVLRLRGRLDLDALQRSFDSLV 92 Query: 751 RRHEVLQTVFRSTDQGQLEQVVGTQPVAELELVEADTGPNGALSLPAALDLLQQRHGQPF 810 RHE L+T FR D + Q + L++V GAL+ + +PF Sbjct: 93 ARHETLRTRFR-LDGDEARQEIAASMALPLDIVALGPLEEGALARQVETTI-----ARPF 146 Query: 811 DLTHGPLVRACLLALDDGSHVLGMVMHHIISDGASMHLLIEELAQLYAELHAGRQSALAP 870 DL GPL+R LL L + HVL +V HHI+SDG SM +++EEL QLYA G + AL Sbjct: 147 DLERGPLLRVSLLRLAEDDHVLVLVQHHIVSDGWSMQVMVEELVQLYAAYSRGLEVALPA 206 Query: 871 AILHYVDYIAWQQARADDPEHRVALDYWTRELAVPAGQAQPVLALPVDRARPVLARYHAS 930 + Y DY WQ++ + E L YWT L G QPVL LP DR RPV + + Sbjct: 207 LPIQYADYALWQRSWMEAGEKERQLAYWTGLL----GGEQPVLELPFDRPRPVRQSHRGA 262 Query: 931 HHHFALPDDLLAGLRGQARQAGMTLFALLLSGLQALLHRYTGQQDIRVGVPVANRSHPDL 990 L DL LR A+Q G T FALLL+ QALL+RY+GQ DIRVGVP+ANR+ + Sbjct: 263 QFILELDIDLSQALRRVAQQEGATAFALLLASFQALLYRYSGQADIRVGVPIANRNRVET 322 Query: 991 LGVVGFFVNTLVLRAPFDEDITLAQLLAQTAQRTLLAQRHQGLPFEQLVEVLQPERSLTH 1050 ++GFFVNT VL+A D + +LLAQ QR L AQ HQ LPFEQLVE LQPERSL+H Sbjct: 323 ERLIGFFVNTQVLKADLDGRMGFDELLAQARQRALEAQAHQDLPFEQLVEALQPERSLSH 382 Query: 1051 SALFQVMFNHLPQHYAASAQGLGDV-------VEELFLPDREAQFELTLDTREHPDGRVS 1103 + LFQV+FN Y + A+G G +E + R AQF+LTLD + + R Sbjct: 383 NPLFQVLFN-----YQSEARGNGQAFRFDELQMESVQFDSRTAQFDLTLDLTDE-EQRFC 436 Query: 1104 AVLTYAKELFDPQRIAQLAQSYLAILRALVDEPQQLVAEVALL-SPAQQAQLQQWGCNPQ 1162 AV YA +LFD + +LA + +LR +V P+Q + E+ LL +P ++ L +W + Sbjct: 437 AVFDYATDLFDASTVERLAGHWRNLLRGIVANPRQRLGELPLLDAPERRQTLSEWNPAQR 496 Query: 1163 RYPLDPPIHVRIAQQARRTPEAIALVLDRQQLSYAQLEARANQMARQLLAMGVQPEQRIG 1222 + + R +QAR+ P+A+AL+LD Q+LSY +L ARAN++A L+A GV + +G Sbjct: 497 ECAVQGTLQQRFEEQARQRPQAVALILDEQRLSYGELNARANRLAHCLIARGVGADVPVG 556 Query: 1223 LALERSLDMVPALLAILKAGACFVPLDPQYPRARLTAMIEDSRIRLALTQSHMREHLPGQ 1282 LALERSLDM+ LLAILKAG ++PLDP P RL +++DS +RL LTQ H+ E LP Q Sbjct: 557 LALERSLDMLVGLLAILKAGGAYLPLDPAAPEERLAHILDDSGVRLLLTQGHLLERLPRQ 616 Query: 1283 AGVRWLELDRLPAPAATSDFMEAPDVITHPA-QLAYVIYTSGSTGRPKGVAVSH-GALVE 1340 AGV L +D L + E+ + T A LAYVIYTSGSTG+PKG ++H AL Sbjct: 617 AGVEVLAIDGL----VLDGYAESDPLPTLSADNLAYVIYTSGSTGKPKGTLLTHRNALRL 672 Query: 1341 HTQLSAEFSRLRNDDRMLQFATLNFDGFIEQLFPPLLVGASVVLRGPQLW---SPEEFQQ 1397 + A F D L F + FD + ++F LL G +V+ PQ W SPE+F + Sbjct: 673 FSATEAWFGFDERDVWTL-FHSYAFDFSVWEIFGALLYGGCLVIV-PQ-WVSRSPEDFYR 729 Query: 1398 RL-REHDISIADLPTAYWHALIQSFARQGQSDYGRLREIHIGGEAMPAESIATWRQA-GL 1455 L RE + P+A+ + + + + LR + GGEA+ +S+ W Q G Sbjct: 730 LLCREGVTVLNQTPSAFKQLMAVACSADMATQQPALRYVIFGGEALDLQSLRPWFQRFGD 789 Query: 1456 SAVRLLNTYGPTEAVVVASLLDCDPFVQGQREVPTQMPIGQPLAGRSLHVLDERLQALPA 1515 +L+N YG TE V + P + E PIG + S ++LD L +P Sbjct: 790 RQPQLVNMYGITETTVHVT---YRPVSEADLEGGLVSPIGGTIPDLSWYILDRDLNPVPR 846 Query: 1516 GVPGELYIGGDLLARGYLERPGLTAERFVADPG-SEAGGRLYRTGDLVCWNAQSELHYLG 1574 G GELYIG LARGYL RPGL+A RFV +P AG RLYRTGDL + A + Y+G Sbjct: 847 GAVGELYIGRAGLARGYLRRPGLSATRFVPNPFPGGAGERLYRTGDLARFQADGNIEYIG 906 Query: 1575 RSDLQVKLRGFRVELGEIEAQLLAQPEVRQAIVVAHQ----ARLVGY--ASLYPGQELST 1628 R D QVK+RGFR+ELGEIEA L VR A+V+AH +LVGY A E Sbjct: 907 RIDHQVKVRGFRIELGEIEAALAGLAGVRDAVVLAHDGVGGTQLVGYVVADSAEDAERLR 966 Query: 1629 AQLRERLRASLPDYMVPATVIVLEQLPTNPNGKIDRHALPAP-ADVIAVGGLAPVGQLEE 1687 LRE L+ LPDYMVPA +++LE++P NGK+DR ALP P A + AP +LE+ Sbjct: 967 ESLRESLKRHLPDYMVPAHLMLLERMPLTVNGKLDRQALPQPDASLSQQAYRAPGSELEQ 1026 Query: 1688 QLGGIWRELLRLEQVGRDDNFFELGGHSLLLLVAHERIKALSLACVPSVVDLFRYPTIAT 1747 ++ IW E+L +E+VG DDNFFELGGHSLL R++ S+ LF P + Sbjct: 1027 RIAAIWSEILGVERVGLDDNFFELGGHSLLATRVISRVRQ-EQQLDASLKALFERPVLEA 1085 Query: 1748 LAAFLD 1753 A L+ Sbjct: 1086 FAQGLE 1091 Score = 114 bits (285), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 185/713 (25%), Positives = 283/713 (39%), Gaps = 146/713 (20%) Query: 20 ERLEQLARERPDDTALIVVQAVAGVDQERRFSYQVLAQRVRALAAVLQARLGRG------ 73 +R E+ AR+RP QAVA + E+R SY L R LA L AR G G Sbjct: 506 QRFEEQARQRP--------QAVALILDEQRLSYGELNARANRLAHCLIAR-GVGADVPVG 556 Query: 74 ---ERALILLDNDEYYAISMFACFYAGVIAVPVFPPESASAAHTGRLAGIAADAGARGLL 130 ER+L +L + + A AG +P+ P AA RLA I D+G R LL Sbjct: 557 LALERSLDML-------VGLLAILKAGGAYLPLDP-----AAPEERLAHILDDSGVRLLL 604 Query: 131 ILDANRALVAACEGLQQAEMIAVDQI---GAGDRGPWQAAAPDPQEIAFLQYTSGSTSAP 187 L+ E++A+D + G + P + D +A++ YTSGST P Sbjct: 605 ---TQGHLLERLPRQAGVEVLAIDGLVLDGYAESDPLPTLSAD--NLAYVIYTSGSTGKP 659 Query: 188 KGVMVTHAALMANEAAIREGLSIGEGDSFCVWSPLFHDMGLIGGLLQPF----YSGIVCV 243 KG ++TH + +A E D VW+ LFH + + F Y G C+ Sbjct: 660 KGTLLTHRNALRLFSATEAWFGFDERD---VWT-LFHSYAFDFSVWEIFGALLYGG--CL 713 Query: 244 LCSPRYFLERPVRWLQMIARHRVSISGGPDFAYR-----LCLDRIKDRQLEGLDLSCWRV 298 + P++ P + +++ R V++ A++ C + +Q R Sbjct: 714 VIVPQWVSRSPEDFYRLLCREGVTVLNQTPSAFKQLMAVACSADMATQQ------PALRY 767 Query: 299 AYTGAEPVRHQTMEAFVQRFASVGLDPAAVYPCYGLAEATLFVTGGRRGAGLRVQRYLPH 358 G E + Q++ + QRF G + YG+ E T+ VT Y P Sbjct: 768 VIFGGEALDLQSLRPWFQRF---GDRQPQLVNMYGITETTVHVT------------YRPV 812 Query: 359 ALRSRLALPADAEEPAVALVACGRAPSQHQVRIAADASGAPAAPGGIGEIWVTGPSIARG 418 + AD E V+ + G P + D + P G +GE+++ +ARG Sbjct: 813 S-------EADLEGGLVSPIG-GTIPDLSWYILDRDLN--PVPRGAVGELYIGRAGLARG 862 Query: 419 YWKQALQSAQTFVEL-----ENQTWLRTGDLG-FWADGELFVAGRLKDMIIVRGHNIYPQ 472 Y ++ SA FV + RTGDL F ADG + GR+ + VRG I Sbjct: 863 YLRRPGLSATRFVPNPFPGGAGERLYRTGDLARFQADGNIEYIGRIDHQVKVRGFRIEL- 921 Query: 473 DLEQALEAEVEALRKGRIAVFAVSLDTEEGVG----VAVEVSRGMQKLVAPQALCEAVAT 528 E+EA G V + +GVG V V+ + + L E++ Sbjct: 922 -------GEIEAALAGLAGVRDAVVLAHDGVGGTQLVGYVVADSAED---AERLRESLRE 971 Query: 529 VVQRQCGE--APQVLVLLNPGGLPKTSSGKLQRGACRTGWHQGSLDAYAVFEQGRMVQGS 586 ++R + P L+LL +P T +GKL R A S AY Sbjct: 972 SLKRHLPDYMVPAHLMLLER--MPLTVNGKLDRQALPQPDASLSQQAY------------ 1017 Query: 587 QSTTMATVPPVAAQRAGEPEVRAALALLWQEVLMPGVAGEPSADAHFLACGGNSLAAVQL 646 RA E+ +A +W E+L G D +F GG+SL A ++ Sbjct: 1018 --------------RAPGSELEQRIAAIWSEILGVERVG---LDDNFFELGGHSLLATRV 1060 Query: 647 AARISQHWQIAFAASQVFEYPRLQQQAALILDALEDGKGGTATGIARLSEAQR 699 +R+ Q Q+ + +FE P +L+A G T ++ + A R Sbjct: 1061 ISRVRQEQQLDASLKALFERP--------VLEAFAQGLERTTDAVSTIPLADR 1105 >PA2402_1 [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins Pae Pseudomonas aeruginosa Length = 1541 Score = 712 bits (1837), Expect = 0.0, Method: Compositional matrix adjust. Identities = 449/1062 (42%), Positives = 611/1062 (57%), Gaps = 53/1062 (4%) Query: 705 LSSAQQRQWFLWQLAPQSTAYHVQGALRLGGPLDVFALQRAFNALMRRHEVLQTVFRSTD 764 LS AQQR WFLW L PQS AY++ A+RL GPLD AL+RAF +L++RHE L+TVF Sbjct: 52 LSYAQQRMWFLWHLEPQSGAYNLPSAVRLNGPLDRQALERAFASLVQRHETLRTVFPRGA 111 Query: 765 QGQLEQVVGTQPVAELELVEADTGPNGALSLPAALDLLQQRHG-QPFDLTHGPLVRACLL 823 L Q +P LE+ D A L QR QPFDL GPL+R L+ Sbjct: 112 DDSLAQAPLQRP---LEVAFEDCSGLPEDEQEARLREEAQRESLQPFDLCEGPLLRVRLI 168 Query: 824 ALDDGSHVLGMVMHHIISDGASMHLLIEELAQLYAELHAGRQSALAPAILHYVDYIAWQQ 883 L + HVL + +HHI+SDG SM++LIEE ++ Y+ G + L + Y DY WQ+ Sbjct: 169 RLGEERHVLLLTLHHIVSDGWSMNVLIEEFSRFYSAYATGAEPGLPALPIQYADYALWQR 228 Query: 884 ARADDPEHRVALDYWTRELAVPAGQAQPVLALPVDRARPVLARYHASHHHFALPDDLLAG 943 + + E L+YW +L G+ PVL LP D RP + Y S + F++ L Sbjct: 229 SWLEAGEQERQLEYWRGKL----GERHPVLELPTDHPRPAVPSYRGSRYEFSIEPALAEA 284 Query: 944 LRGQARQAGMTLFALLLSGLQALLHRYTGQQDIRVGVPVANRSHPDLLGVVGFFVNTLVL 1003 LRG AR+ G+TLF LLL G LL RY+GQ D+RVGVP+ANR+ ++ G++G FVNT VL Sbjct: 285 LRGTARRQGLTLFMLLLGGFNILLQRYSGQTDLRVGVPIANRNRAEVEGLIGLFVNTQVL 344 Query: 1004 RAPFDEDITLAQLLAQTAQRTLLAQRHQGLPFEQLVEVLQPERSLTHSALFQVMFNHLPQ 1063 R+ FD ++A LLA L AQ HQ LPFE+LVE + ERSL+HS LFQVM+NH P Sbjct: 345 RSVFDGRTSVATLLAGLKDTVLGAQAHQDLPFERLVEAFKVERSLSHSPLFQVMYNHQP- 403 Query: 1064 HYAASAQGLGDV----VEELFLPDREAQFELTLDTREHPDGRVSAVLTYAKELFDPQRIA 1119 A + L V +L R QF+L+LDT E GR+ A LTYA +LF+ + + Sbjct: 404 -LVADIEALDSVAGLSFGQLDWKSRTTQFDLSLDTYEK-GGRLYAALTYATDLFEARTVE 461 Query: 1120 QLAQSYLAILRALVDEPQQLVAEVALLSPAQQAQ-LQQWGCNPQRYPLDPPIHVRIAQQA 1178 ++A+ + +LR +++ PQ V + +L ++ Q L+ W YPL +H +Q Sbjct: 462 RMARHWQNLLRGMLENPQASVDSLPMLDAEERGQLLEGWNATAAEYPLQRGVHRLFEEQV 521 Query: 1179 RRTPEAIALVLDRQQLSYAQLEARANQMARQLLAMGVQPEQRIGLALERSLDMVPALLAI 1238 RTP A AL ++L YA+L RAN++A L+ GV ++ +G+A+ERS++MV AL+AI Sbjct: 522 ERTPTAPALAFGEERLDYAELNRRANRLAHALIERGVGADRLVGVAMERSIEMVVALMAI 581 Query: 1239 LKAGACFVPLDPQYPRARLTAMIEDSRIRLALTQSHMREHLPGQAGVRWLELDRLPAPAA 1298 LKAG +VP+DP+YP R M+EDS ++L L+QSH++ LP GV+ ++LD+ A A Sbjct: 582 LKAGGAYVPVDPEYPEERQAYMLEDSGVQLLLSQSHLK--LPLAQGVQRIDLDQ--ADAW 637 Query: 1299 TSDFME-APDVITHPAQLAYVIYTSGSTGRPKGVAVSHGALVEHTQLSAEFSRLRNDDRM 1357 + E P V + LAYVIYTSGSTG+PKG H AL + L D + Sbjct: 638 LENHAENNPGVELNGENLAYVIYTSGSTGKPKGAGNRHSALSNRLCWMQQAYGLGVGDTV 697 Query: 1358 LQFATLNFDGFIEQLFPPLLVGASVVLRGP-QLWSPEEFQQRLREHDISIADLPTAYWHA 1416 LQ +FD + + F PL+ GA +V+ P P + + + + + A Sbjct: 698 LQKTPFSFDVSVWEFFWPLMSGARLVVAAPGDHRDPAKLVELINREGVDTLHFVPSMLQA 757 Query: 1417 LIQSFARQGQSDYGRLREIHIGGEAMPAES----IATWRQAGLSAVRLLNTYGPTEAVVV 1472 +Q + + L+ I GEA+PA++ A QAG L N YGPTEA + Sbjct: 758 FLQD---EDVASCTSLKRIVCSGEALPADAQQQVFAKLPQAG-----LYNLYGPTEAAID 809 Query: 1473 ASLLDCDPFVQGQREVPTQMPIGQPLAGRSLHVLDERLQALPAGVPGELYIGGDLLARGY 1532 + C E +PIG+P+A + ++LD L+ +P GV GELY+ G LARGY Sbjct: 810 VTHWTC------VEEGKDAVPIGRPIANLACYILDGNLEPVPVGVLGELYLAGRGLARGY 863 Query: 1533 LERPGLTAERFVADPGSEAGGRLYRTGDLVCWNAQSELHYLGRSDLQVKLRGFRVELGEI 1592 +RPGLTAERFVA P AG R+YRTGDL + A + Y GR D QVKLRG R+ELGEI Sbjct: 864 HQRPGLTAERFVASPFV-AGERMYRTGDLARYRADGVIEYAGRIDHQVKLRGLRIELGEI 922 Query: 1593 EAQLLAQPEVRQAIVVAHQAR-LVGYASLYPGQELSTAQLRERLRA----SLPDYMVPAT 1647 EA+LL P VR+A V+A + LVGY L E RE L A SLP+YMVPA Sbjct: 923 EARLLEHPWVREAAVLAVDGKQLVGYVVL----ESEGGDWREALAAHLATSLPEYMVPAQ 978 Query: 1648 VIVLEQLPTNPNGKIDRHALPAPADVIAVGGL-APVGQLEEQLGGIWRELLRLEQVGRDD 1706 + LE++P +PNGK+DR ALPAP +A G AP +E L IW++LL +EQVG DD Sbjct: 979 WLALERMPLSPNGKLDRKALPAPEVSVAQAGYSAPRNAVERTLAEIWQDLLGVEQVGLDD 1038 Query: 1707 NFFELGGHSLLLLVAHERIKALSLACVPSVVDLFRYPTIATL 1748 NFF LGG S++ + R + L P DLF++ I +L Sbjct: 1039 NFFSLGGDSIVSIQVVSRARQAGLQLSPR--DLFQHQNIRSL 1078 Score = 145 bits (366), Expect = 8e-34, Method: Compositional matrix adjust. Identities = 246/978 (25%), Positives = 397/978 (40%), Gaps = 150/978 (15%) Query: 47 ERRFSYQVLAQRVRALA-AVLQARLGRGERALILLDNDEYYAISMFACFYAGVIAVPVFP 105 E R Y L +R LA A+++ +G + ++ +++ A AG VPV P Sbjct: 534 EERLDYAELNRRANRLAHALIERGVGADRLVGVAMERSIEMVVALMAILKAGGAYVPVDP 593 Query: 106 --PESASAAHTGRLAGIAADAGARGLLILDANRALVAACEGLQQAEMIAVDQIGAGDRGP 163 PE R A + D+G + L+L + + +G+Q+ ++ D Sbjct: 594 EYPEE-------RQAYMLEDSGVQ--LLLSQSHLKLPLAQGVQRIDLDQADAWLENHAEN 644 Query: 164 WQAAAPDPQEIAFLQYTSGSTSAPKGVMVTHAALMANEAAIREGLSIGEGDSFCVWSPLF 223 + + +A++ YTSGST PKG H+AL +++ +G GD+ +P Sbjct: 645 NPGVELNGENLAYVIYTSGSTGKPKGAGNRHSALSNRLCWMQQAYGLGVGDTVLQKTPFS 704 Query: 224 HDMGLIGGLLQPFYSGIVCVLCSPRYFLERPVRWLQMIARHRVSISGGPDFAYRLCLDRI 283 D+ + P SG V+ +P + P + +++I R V F + + Sbjct: 705 FDVS-VWEFFWPLMSGARLVVAAPGDHRD-PAKLVELINREGVDTL---HFVPSMLQAFL 759 Query: 284 KDRQLEGLDLSCWRVAYTGAEPVRHQTMEAFVQRFASVGLDPAAVYPCYGLAEATLFVTG 343 +D + S R+ +G + + A Q+ L A +Y YG EA + VT Sbjct: 760 QDEDVASCT-SLKRIVCSG------EALPADAQQQVFAKLPQAGLYNLYGPTEAAIDVT- 811 Query: 344 GRRGAGLRVQRYLPHALRSRLALPADAEEPAVALVACGRAPSQHQVRIAADASGAPAAPG 403 + + A+P +A +AC D + P G Sbjct: 812 -----------HWTCVEEGKDAVPIGR---PIANLAC----------YILDGNLEPVPVG 847 Query: 404 GIGEIWVTGPSIARGYWKQALQSAQTFVE---LENQTWLRTGDLG-FWADGELFVAGRLK 459 +GE+++ G +ARGY ++ +A+ FV + + RTGDL + ADG + AGR+ Sbjct: 848 VLGELYLAGRGLARGYHQRPGLTAERFVASPFVAGERMYRTGDLARYRADGVIEYAGRID 907 Query: 460 DMIIVRGHNIYPQDLEQALEAEVEALRKGRIAVFAVSLDTEEGVGVAVEVSRGMQKLVAP 519 + +RG I ++E L E +R+ AV AV D ++ VG V S G Sbjct: 908 HQVKLRGLRIELGEIEARL-LEHPWVREA--AVLAV--DGKQLVGYVVLESEGGD---WR 959 Query: 520 QALCEAVATVVQRQCGEAPQVLV---LLNPGGLPKTSSGKLQRGACRTGWHQGSLDAYAV 576 +AL +AT + P+ +V L +P + +GKL R A Sbjct: 960 EALAAHLATSL-------PEYMVPAQWLALERMPLSPNGKLDRKAL-------------- 998 Query: 577 FEQGRMVQGSQSTTMATVPPVAAQRAGEPEVRAA----LALLWQEVLMPGVAGEPSADAH 632 P V+ +AG R A LA +WQ++L GV + D + Sbjct: 999 ----------------PAPEVSVAQAGYSAPRNAVERTLAEIWQDLL--GVE-QVGLDDN 1039 Query: 633 FLACGGNSLAAVQLAARISQHWQIAFAASQVFEYPRLQQQAALILDALEDGKGGTATGIA 692 F + GG+S+ ++Q+ +R Q + + +F++ ++ A + G A+G Sbjct: 1040 FFSLGGDSIVSIQVVSRARQA-GLQLSPRDLFQHQNIRSLALAAKAGAATAEQGPASGEV 1098 Query: 693 RLSEAQRRTPQPLSSAQQRQWFLWQLAPQSTAYHVQGALRLGGPLDVFALQRAFNALMRR 752 L+ QR WF Q P ++ L+ PLD L RA L + Sbjct: 1099 ALAPVQR-------------WFFEQSIPNRQHWNQSLLLQARQPLDGDRLGRALERLQAQ 1145 Query: 753 HEVLQTVFRSTDQGQLEQVVGTQPVAELELVEADTGPNGALSLPAALDLLQQRHGQPFDL 812 H+ L+ FR ++G Q Q L +A G+ + AL QR DL Sbjct: 1146 HDALRLRFRE-ERGAWHQAYAEQAGEPLWRRQA-----GSEEVLLALCEEAQRS---LDL 1196 Query: 813 THGPLVRACLLALDDGSHVLGMVMHHIISDGASMHLLIEELAQLYAELHAGRQSALAPAI 872 GPL+RA L+ + DGS L +V+HH+ DG S +L+E+L +LYA+L A L P Sbjct: 1197 EQGPLLRALLVDMADGSQRLLLVIHHLAVDGVSWRILLEDLQRLYADLDAD----LGP-- 1250 Query: 873 LHYVDYIAWQQARADDPEHRV-ALDYWTRELAVPAGQAQPVLALPVDRARPVLARYHASH 931 Y AW + + R+ LDYW +L ALP + L H Sbjct: 1251 -RSSSYQAWSRHLHEQAGARLDELDYWQAQL------HDAPHALPCENPHGALENRHERK 1303 Query: 932 HHFALPDDLLAGLRGQARQAGMT-LFALLLSGLQALLHRYTGQQDIRVGVPVANRSH--- 987 L + L +A A T + LLL+ L R++G + V + R Sbjct: 1304 LVLTLDAERTRQLLQEAPAAYRTQVNDLLLTALARATCRWSGDASVLVQLEGHGREDLGE 1363 Query: 988 -PDLLGVVGFFVNTLVLR 1004 DL VG+F + LR Sbjct: 1364 AIDLSRTVGWFTSLFPLR 1381 >PA2424_3 [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins Pae Pseudomonas aeruginosa Length = 1520 Score = 706 bits (1822), Expect = 0.0, Method: Compositional matrix adjust. Identities = 460/1094 (42%), Positives = 630/1094 (57%), Gaps = 61/1094 (5%) Query: 699 RRTPQPLSSAQQRQWFLWQLAPQSTAYHVQGALRLGGPLDVFALQRAFNALMRRHEVLQT 758 R P PLS +QQR WFLWQL P S AY+V G RL GPLDV + A AL++RHE L+T Sbjct: 5 REQPVPLSYSQQRMWFLWQLEPDSPAYNVGGLARLSGPLDVARFEAALQALVQRHETLRT 64 Query: 759 VFRSTDQGQLEQVVGTQPVAELELVEADTGPNGALSLPAALDL-LQQRHGQ--------- 808 F S D +++V G D G + +ALD +Q+H Q Sbjct: 65 TFPSVDGVPVQRVHG------------DGGLHMDWQDFSALDRDSRQQHLQTLADSEAHR 112 Query: 809 PFDLTHGPLVRACLLALDDGSHVLGMVMHHIISDGASMHLLIEELAQLYAELHAGRQSAL 868 PFDL GPL+R C++ + + H L + +HHI+++G +M + EL LY R+S L Sbjct: 113 PFDLESGPLLRVCMVKMAEREHYLVVTLHHIVTEGWAMDIFARELGALYEAFLDDRESPL 172 Query: 869 APAILHYVDYIAWQQARADDPEHRVALDYWTRELAVPAGQAQPVLALPVDRARPVLARYH 928 P + Y+DY WQ+ + E + LDYW +L G P+L LP DR RP + + Sbjct: 173 EPLPVQYLDYSVWQREWLESGERQRQLDYWKAQL----GNEHPLLELPGDRPRPPVQSHQ 228 Query: 929 ASHHHFALPDDLLAGLRGQARQAGMTLFALLLSGLQALLHRYTGQQDIRVGVPVANRSHP 988 + F L +L +R G+T+F + + L ALL+RY+GQQD+R+G PVANR P Sbjct: 229 GDLYRFDLSPELAERVRRFNAARGLTMFMTMTATLAALLYRYSGQQDLRIGAPVANRIRP 288 Query: 989 DLLGVVGFFVNTLVLRAPFDEDITLAQLLAQTAQRTLLAQRHQGLPFEQLVEVLQPERSL 1048 + G++G F+NT VLR D +++ +LL Q Q + Q HQ LPF+ LVE LQP RS Sbjct: 289 ESEGLIGAFLNTQVLRCRLDGQMSVGELLEQVRQTVIDGQSHQDLPFDHLVEALQPPRSA 348 Query: 1049 THSALFQVMFNHLPQHYAASAQGLGDVVEELFLPDREAQFELTLDTREHPDGRVSAVLTY 1108 ++ LFQVM N + + Q G VE + R +F+L L+ + D R+ LTY Sbjct: 349 AYNPLFQVMCNVQRWEFQQTRQLAGMTVEYIANDARATKFDLNLEVTDL-DQRLGCCLTY 407 Query: 1109 AKELFDPQRIAQLAQSYLAILRALVDEPQQLVAEVALLSPAQQAQLQQWGCNPQRYPLDP 1168 +++LFD RIA++A + +L AL+ +PQ+ +AE+ L + ++ QL G + L Sbjct: 408 SRDLFDEPRIARMAGHWQNLLEALLGDPQRRIAELPLFAAEERKQLLLAGTAGE-AGLQD 466 Query: 1169 PIHVRIAQQARRTPEAIALVLDRQQLSYAQLEARANQMARQLLAMGVQPEQRIGLALERS 1228 +H A + +P+A AL Q LSYA+L+AR+N++AR L + GV PE R+GLALERS Sbjct: 467 TLHGLFAARVAASPQAPALTFAGQTLSYAELDARSNRLARVLRSHGVGPEVRVGLALERS 526 Query: 1229 LDMVPALLAILKAGACFVPLDPQYPRARLTAMIEDSRIRLALTQSHMREHLPGQ--AGV- 1285 L+MV LLAILKAG +VPLDP+YP RL MIEDS +RL L+ + + E L G+ AGV Sbjct: 527 LEMVVGLLAILKAGGAYVPLDPEYPLERLQYMIEDSGVRLLLSHAALFEAL-GELPAGVA 585 Query: 1286 RW-LELDRLPAPAATSDFMEAPDVITHPAQLAYVIYTSGSTGRPKGVAVSHGALVEHTQL 1344 RW LE D PA ++ ++ P AY+IYTSGSTG+PKGVAVSHG + H Sbjct: 586 RWCLEED---GPALDAEDPAPLAALSGPQHQAYLIYTSGSTGKPKGVAVSHGEIAMHCAA 642 Query: 1345 SAEFSRLRNDDRMLQFATLNFDGFIEQLFPPLLVGASVVLRGPQLWSPEEFQQRLREHDI 1404 E +R +D L F ++NFD E+L PLL GA VVLR W EE + +R + Sbjct: 643 VIECFGMRAEDCELHFYSINFDAASERLLAPLLCGARVVLRAQGQWGAEEICELIRAEGV 702 Query: 1405 SIADLPTAYWHALIQSFARQGQSDYGRLREIHIGGEAMPAESIATWRQAGLSAVRLLNTY 1464 SI +Y L Q QG+ +R GGEA+ E + RQA + N Y Sbjct: 703 SILGFTPSYGSQLAQWLESQGRQ--LPVRMCITGGEALTGEHLQRIRQA-FAPASFFNAY 759 Query: 1465 GPTEAVVVA-SLLDCDPFVQGQREVPTQMPIGQPLAGRSLHVLDERLQALPAGVPGELYI 1523 GPTE VV+ + L + +G V PIG + R ++LD L +P G GELY+ Sbjct: 760 GPTETVVMPLACLAPERLEEGAASV----PIGSVVGARVAYILDADLALVPQGATGELYV 815 Query: 1524 GGDLLARGYLERPGLTAERFVADPGSEAGGRLYRTGDLV--CWNAQSELHYLGRSDLQVK 1581 GG LARGY ERP L+AERFV DP + GGRLYRTGDLV C N Q E Y+GR D QVK Sbjct: 816 GGAGLARGYHERPALSAERFVPDPFAAEGGRLYRTGDLVRLCDNGQVE--YVGRIDHQVK 873 Query: 1582 LRGFRVELGEIEAQLLAQPEVRQAIVVAHQA----RLVGYASLYPGQELSTAQ------L 1631 +RGFR+ELGEIEA+LL P+VR+A+V+A + +L GY + ++ AQ L Sbjct: 874 IRGFRIELGEIEARLLEHPQVREALVLALDSPSGKQLAGYVASAVAEQDEDAQAALREAL 933 Query: 1632 RERLRASLPDYMVPATVIVLEQLPTNPNGKIDRHALPAPADVIAVGGL-APVGQLEEQLG 1690 + L+ LPDYMVPA +++L LP NGK+DR ALPAP + AP LE+QL Sbjct: 934 KTHLKQQLPDYMVPAHLLLLASLPLTANGKLDRRALPAPDPALNRQAYEAPRSVLEQQLA 993 Query: 1691 GIWRELLRLEQVGRDDNFFELGGHSLLLLVAHERIKALSLACVPSVVDLFRYPTIATLAA 1750 G+WRE+L +E+VG DNFFELGG S+L + R + L + P DLF++ T+ +LAA Sbjct: 994 GVWREVLNVERVGLGDNFFELGGDSILSIQVVSRARQLGIHFSPR--DLFQHQTVQSLAA 1051 Query: 1751 FLDGAAPTRNDAGP 1764 + ++ + GP Sbjct: 1052 VARHSQASQAEQGP 1065 Score = 154 bits (388), Expect = 2e-36, Method: Compositional matrix adjust. Identities = 303/1127 (26%), Positives = 463/1127 (41%), Gaps = 168/1127 (14%) Query: 50 FSYQVLAQRVRALAAVLQAR-LGRGERALILLDNDEYYAISMFACFYAGVIAVPVFPPES 108 SY L R LA VL++ +G R + L+ + + A AG VP+ P Sbjct: 492 LSYAELDARSNRLARVLRSHGVGPEVRVGLALERSLEMVVGLLAILKAGGAYVPLDPEYP 551 Query: 109 ASAAHTGRLAGIAADAGARGLLILDANRALVAACEGLQ--------QAEMIAVDQIGAGD 160 RL + D+G R LL ++ AL A L + + A+D A D Sbjct: 552 LE-----RLQYMIEDSGVRLLL---SHAALFEALGELPAGVARWCLEEDGPALD---AED 600 Query: 161 RGPWQAAAPDPQEIAFLQYTSGSTSAPKGVMVTHAALMANEAAIREGLSIGEGDSFCVWS 220 P AA PQ A+L YTSGST PKGV V+H + + AA+ E + D + Sbjct: 601 PAPL-AALSGPQHQAYLIYTSGSTGKPKGVAVSHGEIAMHCAAVIECFGMRAEDCELHFY 659 Query: 221 PLFHDMGLIGGLLQPFYSGIVCVLCSPRYFLERPVRW-----LQMIARHRVSISG-GPDF 274 + D LL P +LC R L +W ++I VSI G P + Sbjct: 660 SINFDAA-SERLLAP-------LLCGARVVLRAQGQWGAEEICELIRAEGVSILGFTPSY 711 Query: 275 AYRLCLDRIKDRQLEGLDLSCWRVAYTGAEPVRHQTMEAFVQRFASVGLDPAAVYPCYGL 334 +L + + +G L R+ TG E + + ++ Q FA PA+ + YG Sbjct: 712 GSQLA----QWLESQGRQLPV-RMCITGGEALTGEHLQRIRQAFA-----PASFFNAYGP 761 Query: 335 AEATLFVTGGRRGAGLRVQRYLPHALRSRLALPADAEEPAVALVACGRAPSQHQVRIAAD 394 E + +P A + L A + V R V D Sbjct: 762 TETVV----------------MPLACLAPERLEEGAASVPIGSVVGAR------VAYILD 799 Query: 395 ASGAPAAPGGIGEIWVTGPSIARGYWKQALQSAQTFV----ELENQTWLRTGDLGFWAD- 449 A A G GE++V G +ARGY ++ SA+ FV E RTGDL D Sbjct: 800 ADLALVPQGATGELYVGGAGLARGYHERPALSAERFVPDPFAAEGGRLYRTGDLVRLCDN 859 Query: 450 GELFVAGRLKDMIIVRGHNIYPQDLEQALEAEVEALRKGRIAVFAVSLDTEEGVGVAVEV 509 G++ GR+ + +RG I ++E L E +R+ + ++LD+ G +A V Sbjct: 860 GQVEYVGRIDHQVKIRGFRIELGEIEARL-LEHPQVREALV----LALDSPSGKQLAGYV 914 Query: 510 SRGM--QKLVAPQALCEAVATVVQRQCGEAPQVLVLLNPGGLPKTSSGKLQRGACRTGWH 567 + + Q A AL EA+ T +++Q + LL LP T++GKL R A Sbjct: 915 ASAVAEQDEDAQAALREALKTHLKQQLPDYMVPAHLLLLASLPLTANGKLDRRALPAPDP 974 Query: 568 QGSLDAYAVFEQGRMVQGSQSTTMATVPPVAAQRAGEPEVRAALALLWQEVLMPGVAGEP 627 + AY E R V Q LA +W+EVL G Sbjct: 975 ALNRQAY---EAPRSVLEQQ-----------------------LAGVWREVLNVERVG-- 1006 Query: 628 SADAHFLACGGNSLAAVQLAARISQHWQIAFAASQVFEYPRLQQQAALILDALEDGKGGT 687 +F GG+S+ ++Q+ +R Q I F+ +F++ +Q AA Sbjct: 1007 -LGDNFFELGGDSILSIQVVSRARQ-LGIHFSPRDLFQHQTVQSLAA------------- 1051 Query: 688 ATGIARLSEAQRRTPQPLSSAQQ----RQWFLWQLAPQSTAYHVQGALRLG--GPLDVFA 741 +AR S+A + P+ + WF P + H AL L +D+ Sbjct: 1052 ---VARHSQASQAEQGPVQGDSALTPIQHWFF--DLPLARREHWNQALLLQPRQAIDLGL 1106 Query: 742 LQRAFNALMRRHEVLQTVFRSTDQGQLEQVVGTQPVAELELVEADTGPNGALSLPAALDL 801 L+++ L+ +H+ L+ FR D L Q +P+ E EL+ P + A L Sbjct: 1107 LRKSLQRLVEQHDALRLAFRQVDGEWLAQ---HRPLREQELLW--HVPVQSFDECAELFA 1161 Query: 802 LQQRHGQPFDLTHGPLVRACLLALDDGSHVLGMVMHHIISDGASMHLLIEELAQLYAELH 861 QR DL GPL+RA L+ G L + +HH++ DG S +L+E+L Q+Y + Sbjct: 1162 KAQRS---LDLEQGPLLRAVLVDGPAGEQRLLLAIHHLVVDGVSWRVLLEDLQQVYRQFA 1218 Query: 862 AGRQSALAPAILHYVDYIAWQQARADDPEHRVALDYWTRELAVPAGQAQPVLALPVDRAR 921 G + AL + D+ QA A R L +W L QPV P DR + Sbjct: 1219 EGAEPALPAKTSAFRDWAGRLQAYAGSESLREELGWWQARLG-----GQPV-EWPCDRPQ 1272 Query: 922 PVLARYHASHHHFALPDDLLAGLRGQARQAGMT-LFALLLSGLQALLHRYTGQQDIRVGV 980 A L L QA A T + LLL+ L +L R++GQ V + Sbjct: 1273 GDNREALAESVSLRLDPQRTRQLLQQAPAAYRTQVNDLLLTALARVLCRWSGQPSTLVQL 1332 Query: 981 PVANR----SHPDLLGVVGFFVNTLVLRAPFDEDITLAQLLAQT---AQRTLLAQRHQGL 1033 R DL VG+F + LR +T AQ ++ + L A H+GL Sbjct: 1333 EGHGREALFDDIDLTRSVGWFTSAYPLR------LTPAQSPGESIKAIKEQLRAVPHKGL 1386 Query: 1034 PFEQLVEVLQPERSLTHSAL--FQVMFNHLPQHYAASAQGLGDVVEELFLPDREAQ---- 1087 + L + P +AL + FN+L Q + A L +++ P + Q Sbjct: 1387 GYGVLRYLADPAVRQAMAALPTAPITFNYLGQFDQSFADALFQPLDQPTGPIHDEQAPLP 1446 Query: 1088 FELTLDTREHPDGRVSAVLTYAKELFDPQRIAQLAQSYLAILRALVD 1134 EL++D + + G + TY++E +D + + +LAQ+YLA L+AL++ Sbjct: 1447 NELSVDGQVY-GGELVLRWTYSRERYDARTVNELAQAYLAELQALIE 1492