BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.2200.p (614 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value FN0614 [V] COG1132 ABC-type multidrug transport system, ATPase a... 306 7e-83 SA2217 [V] COG1132 ABC-type multidrug transport system, ATPase a... 305 3e-82 YPO0771 [V] COG1132 ABC-type multidrug transport system, ATPase ... 300 8e-81 YPO1913 [V] COG1132 ABC-type multidrug transport system, ATPase ... 290 5e-78 RSc1808 [V] COG1132 ABC-type multidrug transport system, ATPase ... 288 4e-77 >FN0614 [V] COG1132 ABC-type multidrug transport system, ATPase and permease components Fnu Fusobacterium nucleatum Length = 578 Score = 306 bits (785), Expect = 7e-83, Method: Compositional matrix adjust. Identities = 182/563 (32%), Positives = 312/563 (55%), Gaps = 3/563 (0%) Query: 34 LLALTRTRPGPLLIATLAGIAAAILSLTPNLVAYHFSLALLHASLDQERLIALVGWLIGG 93 LL+ + L ++ + ++IL + P ++ Y+ L LL LD R+ L + Sbjct: 17 LLSYAKNEKYKLYLSAFLSVCSSILMVVPYILIYNIILELLKTDLDYNRIKHLAIYTAIL 76 Query: 94 TLAGRLCFLASQVSSHLMAADIQTELRGQLLSRLVNVPLGFFQDHSSQKIRQVVIDDVEQ 153 + + F+ S V SH+ A +I +R Q + L N+ LG+F++ + +I++ + +DVE+ Sbjct: 77 IVVRLILFILSGVFSHVAAFNILYNIRMQTVKHLGNINLGYFRERNIGEIKKAINEDVEK 136 Query: 154 LEDGLAHLIPELTSHFIAPLIVIAALFAVDWRLSLASLSSLVLGMVACMLLMRKRHDIAQ 213 LE+ LAH IP+L + P +++ LF ++WR+++ + ++L ++ + + + Sbjct: 137 LENFLAHQIPDLAAAITTPAVLLIFLFFLEWRIAIFLIIPIILAILTQIAMFKDYGKRLD 196 Query: 214 DFYLNQGKLFKAMTEILRTMPAARLFNSGAAMQARVEEANGDYVGTAHRWVRGALLPNLV 273 ++ +L +T+ ++ M + FN A + + N +Y H P + Sbjct: 197 NYNSLLQRLTSTITQYIKGMNVFKAFNLTAHSFKKYIDVNNEYTENWHSMTDDFKNPYGI 256 Query: 274 MQVLVSSPLLLLLPLGLWWHQQGSLDLATLCFFVFFTPGLGNLLTKLAGFSNRFVQQQQA 333 +V S L+ ++P G + + ++++TL F+ + L L F+ F Sbjct: 257 FLAVVDSALIFVIPSGGYLYLTDKINISTLLIFLLLSYTFLTSLKTLMQFAGTFSFVLAG 316 Query: 334 FEHLDILLGAPEQSEGSH-TSLPEKITIRCEQVSFSYHQQAVLDNLSLTLHPGTTTALVG 392 ++ ++ P Q++G + + K I V+FSY + VL N++L L P T TALVG Sbjct: 317 ANNVRSMIEFPIQNDGKNLKDINFKEDISFNDVTFSYDKNDVLKNINLILRPNTITALVG 376 Query: 393 GSGSGKSTLVKLLLRHWDVTSGRILLGERPINDYTRETLRQNITCIFQENQLFDMSIADN 452 SGSGK+T+ LL R WD+ G I +G+ I D L NI+ +FQ+ + +I +N Sbjct: 377 PSGSGKTTIAYLLGRFWDIQKGSIKIGDIDIKDIDVNYLLSNISYVFQDIFMLTDTIFEN 436 Query: 453 IRLGKPTATEEEVIQAARAAQAHEFIMALPQGYQTLLAPGSALLSGGEQQRLAIARAILK 512 I++G T+EE+ QAA+ A+ HEFIM+LP GY T++ G LSGGE+QR++IAR +LK Sbjct: 437 IKMG-LDKTKEEIYQAAKDAEIHEFIMSLPNGYDTIIGDGYIKLSGGEKQRISIARCLLK 495 Query: 513 NAPILLLDEATSQADALNEHRIQLALSALAADKTVLVIAHRLSSIAHADQIVVLEQGRVV 572 N+PI++LDE T+ +D NE +IQ A+ L DKT ++IAHRL +I D IVVL +G +V Sbjct: 496 NSPIVVLDEITAYSDIENEAKIQSAIRNLLKDKTAIIIAHRLYTIKDVDNIVVLNEGEIV 555 Query: 573 EQGQHAALLLQQ-GRYASLWQMQ 594 E G+H L+ ++ G Y LW+++ Sbjct: 556 ESGKHQDLITKENGLYKHLWEVK 578 >SA2217 [V] COG1132 ABC-type multidrug transport system, ATPase and permease components Sau Staphylococcus aureus N315 Length = 587 Score = 305 bits (780), Expect = 3e-82, Method: Compositional matrix adjust. Identities = 178/559 (31%), Positives = 294/559 (52%), Gaps = 6/559 (1%) Query: 44 PLLIATLAGIAAAILSLTPNLVAYHFSLALLHASLDQERLIALVGWLIGGTLAGRLCFLA 103 ++++ L I + L P + L +++ + ++ + + ++ CF A Sbjct: 21 KIMLSILLSIISVFSGLVPYWAVFKIILMMINNAYTINSIMVYIFIALITYISQVCCFGA 80 Query: 104 SQVSSHLMAADIQTELRGQLLSRLVNVPLGFFQDHSSQKIRQVVIDDVEQLEDGLAHLIP 163 S + SH+ A +I +E+R +L +L+ +PLG + +++ + +D VE +E LAH+IP Sbjct: 81 STMLSHITAYEILSEIRKKLAQKLMRLPLGVVESKKIGELKNIFVDKVETIELPLAHMIP 140 Query: 164 ELTSHFIAPLIVIAALFAVDWRLSLASLSSLVLGMVACMLLMRKRHDIAQDFYLNQGKLF 223 E+ + + + + +DWR++ A L ++ + + A +M ++ + + + Sbjct: 141 EVIGNLLLSAAIFLYIMLIDWRMASALLVTIPISIFAFKKVMSGFNETYAEQMKSNNYMN 200 Query: 224 KAMTEILRTMPAARLFNSGAAMQARVEEANGDYVGTAHRWVRGAL-LPNLVMQVLVSSPL 282 A+ E + + + FN + + ++A +Y W + NL VL S Sbjct: 201 SAIVEFIEGIEVIKTFNQSQSSYKKYKDAVDNYKIHTLNWFKNTWGYMNLGASVL-PSTF 259 Query: 283 LLLLPLGLWWHQQGSLDLATLCFFVFFTPGLGNLLTKLAGFSNRFVQQQQAFEHLDILLG 342 L +LP+G++ L+ A + + G+ + + N Q A ++ +L Sbjct: 260 LGILPVGMYLISINQLNYAEFFLCIVLSLGVVAPIKNFTNYVNHLKSIQYALTEVNQILS 319 Query: 343 APEQSEGSHTSLPEKITIRCEQVSFSYHQQA---VLDNLSLTLHPGTTTALVGGSGSGKS 399 E + P+ I V FSY++ V +LS T+ TA+VG SGSGKS Sbjct: 320 LEELVLSTKFKKPQHYEIAFNNVGFSYNKDKDDLVFKHLSFTVPENNFTAIVGASGSGKS 379 Query: 400 TLVKLLLRHWDVTSGRILLGERPINDYTRETLRQNITCIFQENQLFDMSIADNIRLGKPT 459 T+ KL+ R+WDVTSG I +G I D + L + + Q+N L +++ +NI+LG P Sbjct: 380 TIAKLISRYWDVTSGEITIGGINIKDIESKQLNDLVGFVGQDNFLLNLTFKENIKLGNPE 439 Query: 460 ATEEEVIQAARAAQAHEFIMALPQGYQTLLAPGSALLSGGEQQRLAIARAILKNAPILLL 519 AT+E V +AA+ AQ HEFI LP GY T + LSGGE+QR+ IAR ILK+API++L Sbjct: 440 ATDEAVEKAAKLAQCHEFIEKLPDGYDTNVGTVGDKLSGGEKQRVTIARMILKDAPIIVL 499 Query: 520 DEATSQADALNEHRIQLALSALAADKTVLVIAHRLSSIAHADQIVVLEQGRVVEQGQHAA 579 DEAT+ D NE +IQ AL+ L DKT++VIAHRLS+I HADQI+VL + +++E+G H Sbjct: 500 DEATAYVDPDNEQKIQEALNVLTQDKTLIVIAHRLSTIQHADQIIVLGKQQILEKGSHHL 559 Query: 580 LLLQQGRYASLWQMQHAHA 598 LL G Y +W H H Sbjct: 560 LLKLNGNYKKMWD-THMHT 577 >YPO0771 [V] COG1132 ABC-type multidrug transport system, ATPase and permease components Ype Yersinia pestis Length = 590 Score = 300 bits (767), Expect = 8e-81, Method: Compositional matrix adjust. Identities = 204/590 (34%), Positives = 311/590 (52%), Gaps = 19/590 (3%) Query: 29 GAVSRLLALTRTRPGPLLIATLAGIAAAILSLTPNLVAYHFSLALL-HASLDQERLIALV 87 A L+ L T+ L ++ + + ++LSL P ++ Y L H S +L LV Sbjct: 6 SAFRWLIQLLSTQHKRLALSMILAVGYSLLSLVPYVLIYQLIANFLYHPSAATSQLWWLV 65 Query: 88 GWLIGGTLAGRLCF-LASQVSSHLMAADIQTELRGQLLSRLVNVPLGFFQDHSSQKIRQV 146 G + LAG+ LAS + SH A + ELR Q++ R+ +PL H++ K++++ Sbjct: 66 GMAVLA-LAGKAILQLASGLLSHQAAFQLLFELRRQVIERVGRLPLSVSHQHTTAKLKKI 124 Query: 147 VIDDVEQLEDGLAHLIPELTSHFIAPLIVIAALFAVDWRLSLASLSSLVLGMVACMLLMR 206 + DD+ ++E +AH +P++ + + P+ LF DWRL+L +L L +AC+L Sbjct: 125 ISDDIGRIETFVAHHLPDMAAAIVTPIAAAILLFFFDWRLALVALIPLP---IACLLQCW 181 Query: 207 KRHDIAQD---FYLNQGKLFKAMTEILRTMPAARLFNSGAAMQARVEEANGDYVGTAHRW 263 Q +Y L ++ + +++MP + FN R A + W Sbjct: 182 MFQGFNQRITVYYHVVADLHTSIVDFVKSMPLVKAFNMTVNSHQRYTNAVNAHNQLVREW 241 Query: 264 VRGALLPNLVMQVLVSSPLLLLLPLGLWWHQQGSLDLATLCFFVFFTPGLGNLLTKLAGF 323 + + ++ + LL ++P+G+ QG + LA + F+ GL L L F Sbjct: 242 LTETRTATALFKLSLDLGLLCIMPVGIMLFSQGEVTLAVIFMFMLLGIGLMEPLYNLLRF 301 Query: 324 SNRFVQQQQAFEHLDILLGAPEQSEGSHTSLPEKITIRC-EQVSFSY--HQQAVLDNLSL 380 N F + E++ A Q EG T LP K C QVSF + ++ L+ LS Sbjct: 302 GNLFSALLKGVENIREFAHAKPQREG-QTPLPIKHYDICFNQVSFRHPDAKENTLEQLSF 360 Query: 381 TLHPGTTTALVGGSGSGKSTLVKLLLRHWDVTSGRILLGERPINDYTRETLRQNITCIFQ 440 G TALVG SG+GKST +L+ R ++ G I +G+ PI E L +FQ Sbjct: 361 VAKQGEITALVGPSGAGKSTAAQLIPRLYEHQGGDICIGDTPIEMLPLEQLMSLTAFVFQ 420 Query: 441 ENQLFDMSIADNIRLGKPTATEEEVIQAARAAQAHEFIMALPQGYQTLLAPGSALLSGGE 500 + +F+ ++ +NIR+G + TE E+I AA+AA A +FI LP+ YQT++ P + LSGG+ Sbjct: 421 DTFIFNDTVMNNIRMGNDSLTEAEIINAAKAACADDFIEQLPERYQTVIGPET--LSGGQ 478 Query: 501 QQRLAIARAILKNAPILLLDEATSQADALNEHRIQLALSALAADKTVLVIAHRLSSIAHA 560 QR+AIARAI KNAPI+LLDEAT+ ADA NE RIQ ALS L DKTV+VIAHRL+++ H Sbjct: 479 AQRIAIARAIAKNAPIVLLDEATAYADARNEVRIQQALSDLIKDKTVIVIAHRLNTLIHV 538 Query: 561 DQIVVLEQGRVVEQGQHAALLLQQGRYASLWQMQHA----HAVTPAQPTS 606 + I+V+ +GR V +G H LL Y ++W A H T A+ S Sbjct: 539 NHIIVMAEGRKVAEGTHQTLLATHSLYQNMWAAHQAAKIWHFSTDAKAVS 588 >YPO1913 [V] COG1132 ABC-type multidrug transport system, ATPase and permease components Ype Yersinia pestis Length = 600 Score = 290 bits (743), Expect = 5e-78, Method: Compositional matrix adjust. Identities = 189/536 (35%), Positives = 282/536 (52%), Gaps = 16/536 (2%) Query: 85 ALVGWLIGGTLAGRLCFLASQV-------SSHLMAADIQTELRGQLLSRLVNVPLGFFQD 137 A+ W +GG + C + + V +SH A ++ LR +L + + +P G Q Sbjct: 61 AIPAWPLGGVIG---CVVLTFVLRLQAFNTSHYAAFHLENILRSRLARKALQLPPGVLQQ 117 Query: 138 HSSQKIRQVVIDDVEQLEDGLAHLIPELTSHFIAPLIVIAALFAVDWRLSLASLSSLVLG 197 S + +V++DDV+ L +A P I PL I LF +DWRL++A+L L G Sbjct: 118 MGSGSVAKVMLDDVKSLHIFVADSTPLYARAIIMPLATIVILFWLDWRLAIATLGVLAFG 177 Query: 198 MVACMLLMRKRHDIAQDFYLNQGKLFKAMTEILRTMPAARLFNSGAAMQARVEEANGDYV 257 V +L ++ D+AQ ++ + ++ A+ E ++ MP R F+SG+ R + A ++V Sbjct: 178 SVVLVLARQRSEDMAQRYHKAREQVSAAVIEFVQAMPVVRTFDSGSTSFLRYQRALEEWV 237 Query: 258 GTAHRWVRGA-LLPNLVMQVLVSSP-LLLLLPLGLWWHQQGSLDLATLCFFVFFTPGLGN 315 W R A +L P L +L+ G GS D + G+ Sbjct: 238 DVLKTWYRKAGFSARFSFSILNPLPTLFVLIWSGYGLLHYGSFDFIAWVAVLLLGSGMAE 297 Query: 316 LLTKLAGFSNRFVQQQQAFEHLDILLGAPEQSEGSHTSLPEKITIRCEQVSFSYHQQ--- 372 + + +N Q + + + + +L PE S P++ +I EQVSF Y Q Sbjct: 298 AVMPMMMLNNLVAQTRLSIQRIYQVLAMPELSLPQSDQQPQEASITFEQVSFHYPQARTG 357 Query: 373 AVLDNLSLTLHPGTTTALVGGSGSGKSTLVKLLLRHWDVTSGRILLGERPINDYTRETLR 432 A L +S + G ALVG SG+GKST+ +LLLR+ D G I +G + D +TL Sbjct: 358 AALQEVSFHVPAGQIVALVGPSGAGKSTVARLLLRYADPDKGHIRIGGVDLRDMQTDTLM 417 Query: 433 QNITCIFQENQLFDMSIADNIRLGKPTATEEEVIQAARAAQAHEFIMALPQGYQTLLAPG 492 + ++ +FQ+N LF +IA+NIRLG P A E VI AAR AQAH+FI ALP+GY T + Sbjct: 418 KQLSFVFQDNFLFADTIANNIRLGAPDAPLEAVIAAARVAQAHDFISALPEGYNTRVGER 477 Query: 493 SALLSGGEQQRLAIARAILKNAPILLLDEATSQADALNEHRIQLALSALAADKTVLVIAH 552 LSGG++QR+ IARA+L++ PIL+LDEAT+ AD NE + AL+A +TV+++AH Sbjct: 478 GVFLSGGQRQRITIARALLQDRPILVLDEATAFADPENEAALIKALAAAMRGRTVIMVAH 537 Query: 553 RLSSIAHADQIVVLEQGRVVEQGQHAALLLQQGRYASLWQ-MQHAHAVTPAQPTSE 607 RLS + AD I++ G++ E G H LL Q G Y LWQ Q A P E Sbjct: 538 RLSMVTQADVILLFSDGQLREMGNHTQLLAQGGLYQRLWQHYQQAQHWVPGGTQEE 593 >RSc1808 [V] COG1132 ABC-type multidrug transport system, ATPase and permease components Rso Ralstonia solanacearum Length = 618 Score = 288 bits (736), Expect = 4e-77, Method: Compositional matrix adjust. Identities = 194/540 (35%), Positives = 298/540 (55%), Gaps = 6/540 (1%) Query: 62 PNLVAYHFSLALLHASLDQERLIALVGWLIGGTLAGRLCFL---ASQVSSHLMAADIQTE 118 P LV Y + + + L ++GW G LA L +L AS V +HL A DI + Sbjct: 60 PLLVIYAVLMLIGQDRVAASALWPILGW---GALAIGLRWLLLVASGVVAHLAAFDILLD 116 Query: 119 LRGQLLSRLVNVPLGFFQDHSSQKIRQVVIDDVEQLEDGLAHLIPELTSHFIAPLIVIAA 178 LR ++ ++L +PLG+ S++ +V+ +DV++LE +AH + + + PL A Sbjct: 117 LRLKVAAKLTRLPLGWITKQSAEATNKVLREDVDRLELFIAHHLNDSAAAVALPLASAVA 176 Query: 179 LFAVDWRLSLASLSSLVLGMVACMLLMRKRHDIAQDFYLNQGKLFKAMTEILRTMPAARL 238 LF DWR++L +L+++ + + +LL +K ++ + L ++ E ++ + + Sbjct: 177 LFWFDWRMALVTLATVPVAALVQILLWKKIPEVMAQYNEVNASLSASVVEYVQGIAVLKT 236 Query: 239 FNSGAAMQARVEEANGDYVGTAHRWVRGALLPNLVMQVLVSSPLLLLLPLGLWWHQQGSL 298 ++ GA R+ Y R VR + V++ + +L +LP G +W+ QGSL Sbjct: 237 YHRGALASKRLTRVIDAYRAVIARMVRMTVPGWSAFTVVIGANMLSILPFGGYWYLQGSL 296 Query: 299 DLATLCFFVFFTPGLGNLLTKLAGFSNRFVQQQQAFEHLDILLGAPEQSEGSHTSLPEKI 358 L + G+ L LA F + Q + + L+ APE ++ P Sbjct: 297 SLELFVLCLLLGLGITRPLFALAFFGSLLRLIQDSHGRVQNLMQAPELTDAPAAGKPADS 356 Query: 359 TIRCEQVSFSYHQQAVLDNLSLTLHPGTTTALVGGSGSGKSTLVKLLLRHWDVTSGRILL 418 T+ E V F+Y + VL +S T+ G+ TA+VG SG+GKSTL +LL R WDV G I + Sbjct: 357 TVAFEGVGFAYGDKDVLHEVSFTVPAGSFTAIVGPSGAGKSTLAQLLARFWDVGRGAIRI 416 Query: 419 GERPINDYTRETLRQNITCIFQENQLFDMSIADNIRLGKPTATEEEVIQAARAAQAHEFI 478 G + + + + + Q+ LF+ ++ +NIRLG+ E +VI AA+AAQAH+FI Sbjct: 417 GGVDVRALPLGDMHRQVAYVMQDVFLFNDTVLENIRLGQRELDEAQVIAAAKAAQAHDFI 476 Query: 479 MALPQGYQTLLAPGSALLSGGEQQRLAIARAILKNAPILLLDEATSQADALNEHRIQLAL 538 LPQGY T+L A LSGGE+QRL+IARA++K+API++LDEAT+ D ++E +I AL Sbjct: 477 SRLPQGYHTVLGERGARLSGGEKQRLSIARALVKDAPIIVLDEATAFTDPMSEAQILDAL 536 Query: 539 SALAADKTVLVIAHRLSSIAHADQIVVLEQGRVVEQGQHAALLLQQGRYASLWQMQHAHA 598 L KTV+VIAHRLS+IA ADQIV+L+ GRV G HA LL Y LW+M A Sbjct: 537 GVLTQSKTVIVIAHRLSTIADADQIVLLDHGRVAAAGTHAQLLAGSDLYRRLWRMHRDSA 596