BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.2104.p (435 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc2352 [GEPR] COG0477 Permeases of the major facilitator superf... 598 e-170 YPO2237 [GEPR] COG0477 Permeases of the major facilitator superf... 513 e-145 BMEII1096 [GEPR] COG0477 Permeases of the major facilitator supe... 461 e-129 PA4126 [GEPR] COG0477 Permeases of the major facilitator superfa... 397 e-110 RSp1572 [GEPR] COG0477 Permeases of the major facilitator superf... 365 e-100 >RSc2352 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 442 Score = 598 bits (1541), Expect = e-170, Method: Compositional matrix adjust. Identities = 302/432 (69%), Positives = 365/432 (84%) Query: 4 QAGAAADSARASFEDATYSKVTWRLLPLLFLCYVASYLDRVNVGFAKLQMLQDLKFSDTV 63 AGA + + FE+ATY KV+WRL+P L LCYV +YLDRVNVGFAKLQML DLKFS+TV Sbjct: 11 SAGALPPQSASGFEEATYRKVSWRLIPFLLLCYVVAYLDRVNVGFAKLQMLNDLKFSETV 70 Query: 64 YGLGAGIFFLGYFVFEVPSNMILHKVGARLWIARIMITWGIISGAMAYVTTPEMFYIMRF 123 YGLGAGIFF+GYF+FEVPSN+ILH+VGAR+WIARIMI+WG+IS AM +VTTP MFY+MRF Sbjct: 71 YGLGAGIFFIGYFLFEVPSNVILHRVGARMWIARIMISWGLISAAMMFVTTPAMFYVMRF 130 Query: 124 LLGVAEAGFFPGVILYLTYWYPAARRGKITALFMTGIALSGVIGGPFSGWIMHAMPGVWG 183 LLG+AEAGFFPG+ILYLTYWYPA RRG+ T FMT +ALSGVIGGP SGW + GV+G Sbjct: 131 LLGLAEAGFFPGIILYLTYWYPAERRGRTTTFFMTAVALSGVIGGPISGWALKTFGGVYG 190 Query: 184 HTGWQWMFILEAIPSLVLGVLVILYMKDRIRDAEWLSEDEKRLLEANISHEESQKEHLSL 243 GWQWMF++E IPS+V+G+ V+ Y+ +RI A WL+++EK LL NI+ EE+QKE + Sbjct: 191 LAGWQWMFLIEGIPSVVIGLCVLAYLDNRISHARWLTDEEKALLTRNIAAEEAQKEDAPI 250 Query: 244 GAMFANGRVWLGALIYFCFVMGLYGVSFWLPTIIKATGVSDPLNVGLLTAIPYAFAAAAM 303 A+ A+ RVWL +LIYF FVMGLYGVSFWLPT+IK TGV+DPL+VGLLTAIPY A AM Sbjct: 251 AAIMASPRVWLMSLIYFSFVMGLYGVSFWLPTLIKQTGVADPLSVGLLTAIPYGAAVVAM 310 Query: 304 VLIGRSADARRERRWHVAIPAFIGCIGLLLSTLYGHNTALAMASLTLASVGIMTTLPLFW 363 VL+ RSAD RERRWH+AIPA G IGL+LS ++ NT LAMA+LTL ++GI+TTLPLFW Sbjct: 311 VLVARSADRTRERRWHIAIPALAGAIGLVLSAVWHTNTTLAMAALTLGTMGILTTLPLFW 370 Query: 364 SLPTAFLSGTAAAAGIALINSLGNLAGFVSPFLVGWLKDTTQSTNAGMYVLAASLVIGGL 423 SLPTAFL+GT AAAGIALINSLGNLAGF+SP+ VGWLKDTT+ST++GMY+LAAS+V+G L Sbjct: 371 SLPTAFLAGTGAAAGIALINSLGNLAGFLSPYAVGWLKDTTRSTDSGMYLLAASMVLGAL 430 Query: 424 LTLTLPARLVNK 435 LTL++PAR VN+ Sbjct: 431 LTLSVPARTVNR 442 >YPO2237 [GEPR] COG0477 Permeases of the major facilitator superfamily Ype Yersinia pestis Length = 436 Score = 513 bits (1321), Expect = e-145, Method: Compositional matrix adjust. Identities = 250/419 (59%), Positives = 319/419 (76%) Query: 17 EDATYSKVTWRLLPLLFLCYVASYLDRVNVGFAKLQMLQDLKFSDTVYGLGAGIFFLGYF 76 E+ Y K W LLPLL LCYV +YLDRVNVGFAKLQM DL+FSDTVYGLGAG+FF+GYF Sbjct: 18 ENNAYRKTVWHLLPLLMLCYVLNYLDRVNVGFAKLQMADDLQFSDTVYGLGAGMFFIGYF 77 Query: 77 VFEVPSNMILHKVGARLWIARIMITWGIISGAMAYVTTPEMFYIMRFLLGVAEAGFFPGV 136 E+PSN+ILH+VGARLWIARIMITWGIIS MA+VTTP FY+MRFLLGVAEAGFFPG+ Sbjct: 78 FLEIPSNLILHRVGARLWIARIMITWGIISACMAFVTTPMSFYVMRFLLGVAEAGFFPGI 137 Query: 137 ILYLTYWYPAARRGKITALFMTGIALSGVIGGPFSGWIMHAMPGVWGHTGWQWMFILEAI 196 ILY++YW+P+ RRG++ LF+ + LSG+IG P SGWIM G G+ GWQWMFILE I Sbjct: 138 ILYISYWFPSHRRGRVYGLFVISVPLSGIIGAPLSGWIMQYFNGFQGYAGWQWMFILEGI 197 Query: 197 PSLVLGVLVILYMKDRIRDAEWLSEDEKRLLEANISHEESQKEHLSLGAMFANGRVWLGA 256 PS+++G+L+I +KDRI A WL++ EK +L+ NI +E + H L F RVWL Sbjct: 198 PSVLVGILIIYKLKDRITHATWLTDKEKDILQTNIENEAAHYAHSRLRDAFLQPRVWLLT 257 Query: 257 LIYFCFVMGLYGVSFWLPTIIKATGVSDPLNVGLLTAIPYAFAAAAMVLIGRSADARRER 316 LIYFC + G Y + FWLPT+I+ +GV D L++G LTAIP A AA M+++ RSAD RER Sbjct: 258 LIYFCLISGFYTIGFWLPTLIRDSGVKDILSIGFLTAIPSAAAAVTMIVVSRSADRLRER 317 Query: 317 RWHVAIPAFIGCIGLLLSTLYGHNTALAMASLTLASVGIMTTLPLFWSLPTAFLSGTAAA 376 RWH+A+ A +G +G++LST + N +AM LT+ ++G ++T+PLFWSLPTAFL G+AAA Sbjct: 318 RWHLALTAVLGAVGIILSTYFSDNIVVAMVCLTIGAMGALSTIPLFWSLPTAFLGGSAAA 377 Query: 377 AGIALINSLGNLAGFVSPFLVGWLKDTTQSTNAGMYVLAASLVIGGLLTLTLPARLVNK 435 AGIA INS GNL GFV+P+++G+LKD TQST GM +++ +L IG L +PA+ VN Sbjct: 378 AGIAFINSWGNLGGFVAPYMMGYLKDLTQSTTTGMLIISTTLFIGAALVFLIPAKAVNH 436 >BMEII1096 [GEPR] COG0477 Permeases of the major facilitator superfamily Bme Brucella melitensis Length = 451 Score = 461 bits (1185), Expect = e-129, Method: Compositional matrix adjust. Identities = 229/421 (54%), Positives = 316/421 (75%), Gaps = 4/421 (0%) Query: 17 EDATYSKVTWRLLPLLFLCYVASYLDRVNVGFAKLQMLQDLKFSDTVYGLGAGIFFLGYF 76 E+ TY KV +R++PLL +CY+ +YLDRVNVGFAKLQM ++L FS+ +YGLGAG+FF+GYF Sbjct: 33 ENMTYRKVAFRIIPLLMICYIIAYLDRVNVGFAKLQMSEELGFSEAIYGLGAGLFFIGYF 92 Query: 77 VFEVPSNMILHKVGARLWIARIMITWGIISGAMAYVTTPEMFYIMRFLLGVAEAGFFPGV 136 FE+PSN++LHK+GARLWIARIMITWG++S A+V T FYI+RFLLG AEAGF+PGV Sbjct: 93 FFEIPSNILLHKLGARLWIARIMITWGLLSALFAFVQTEWQFYILRFLLGAAEAGFYPGV 152 Query: 137 ILYLTYWYPAARRGKITALFMTGIALSGVIGGPFSGWIMHAMPGVWGHTGWQWMFILEAI 196 ILYLTYW+P+ RRG + ALF G +G+ G P SGWIM G GWQWMF+LEAI Sbjct: 153 ILYLTYWFPSHRRGNMFALFQAGSPAAGIFGNPLSGWIMDQFHDTAGWQGWQWMFVLEAI 212 Query: 197 PSLVLGVLVILYMKDRIRDAEWLSEDEKRLLEANISHEESQK--EHLSLGAMFANGRVWL 254 P++VLGV+++LY+ + ++ A+WL+E+EK ++ +I + K H SL ++ N +W+ Sbjct: 213 PAVVLGVVILLYLDNSVKAAKWLTEEEKAIISRDIEADSKGKAASH-SLMSLVKNPMLWV 271 Query: 255 GALIYFCFVMGLYGVSFWLPTIIKATGVSDPLNVGLLTAIPYAFAAAAMVLIGRSADARR 314 LIYFCFVMG +G++ W+PT+I+A+GV+ + +GLL AIP+ A AMV+ RSAD R Sbjct: 272 MMLIYFCFVMGQHGLTLWMPTLIRASGVTSNVTIGLLGAIPFICAIIAMVIFSRSADHYR 331 Query: 315 ERRWHVAIPAFIGCIGLLLSTLYGHNTALAMASLTLASVGIMTTLPLFWSLPTAFLSGTA 374 ERRWH+ +PA +G +G +++ NT +++ L++A+ G++ PLFWSLPTA LSG A Sbjct: 332 ERRWHLVVPALLGAVGFVVAA-SATNTTVSIIFLSMAAAGVLACAPLFWSLPTAILSGAA 390 Query: 375 AAAGIALINSLGNLAGFVSPFLVGWLKDTTQSTNAGMYVLAASLVIGGLLTLTLPARLVN 434 AAAGIALINS+ NLAGF+SP++VG ++D T S+ GMYVLA L++G + L +PA VN Sbjct: 391 AAAGIALINSVANLAGFISPYMVGIIRDATHSSELGMYVLAGFLILGAAIVLCIPASKVN 450 Query: 435 K 435 + Sbjct: 451 R 451 >PA4126 [GEPR] COG0477 Permeases of the major facilitator superfamily Pae Pseudomonas aeruginosa Length = 434 Score = 397 bits (1019), Expect = e-110, Method: Compositional matrix adjust. Identities = 203/425 (47%), Positives = 290/425 (68%) Query: 10 DSARASFEDATYSKVTWRLLPLLFLCYVASYLDRVNVGFAKLQMLQDLKFSDTVYGLGAG 69 +S D+T+ +VTWRL+PLL +CYV ++LDR+N+GFAKLQM DL FSDTVYGLGAG Sbjct: 8 NSTTLPLSDSTHDRVTWRLMPLLLVCYVFAHLDRINIGFAKLQMSADLHFSDTVYGLGAG 67 Query: 70 IFFLGYFVFEVPSNMILHKVGARLWIARIMITWGIISGAMAYVTTPEMFYIMRFLLGVAE 129 +FF+ Y +F +PSN++L ++G R WIA +M+ WG +S AM V T FY++RFLLGVAE Sbjct: 68 LFFIAYALFGLPSNLMLERIGPRRWIACLMLVWGCLSTAMLLVETARGFYLLRFLLGVAE 127 Query: 130 AGFFPGVILYLTYWYPAARRGKITALFMTGIALSGVIGGPFSGWIMHAMPGVWGHTGWQW 189 AGFFPG+++YL W+PA RRG+ITALF + ++GVIGGP SGWI+ G GWQW Sbjct: 128 AGFFPGILVYLNRWFPARRRGQITALFAIAVPMAGVIGGPLSGWILEGFHDALGLRGWQW 187 Query: 190 MFILEAIPSLVLGVLVILYMKDRIRDAEWLSEDEKRLLEANISHEESQKEHLSLGAMFAN 249 MF++E +P ++LGV+V + + WLS+++K LL ++ EE +K S +F+N Sbjct: 188 MFLIEGLPVVLLGVVVWCSLPESFERVTWLSDEQKHLLREELAGEEQRKTITSFSGIFSN 247 Query: 250 GRVWLGALIYFCFVMGLYGVSFWLPTIIKATGVSDPLNVGLLTAIPYAFAAAAMVLIGRS 309 +VWL IYF ++ + ++FW+P++I G++ +G+L+A+PY A M+ IGRS Sbjct: 248 PQVWLLVAIYFAVMLAVNTIAFWMPSLIHGAGIAQDSRIGMLSAVPYLAGCAFMIFIGRS 307 Query: 310 ADARRERRWHVAIPAFIGCIGLLLSTLYGHNTALAMASLTLASVGIMTTLPLFWSLPTAF 369 +D RERRWH+ IP + GL L+ L + L M L +A +G LP+FW LP AF Sbjct: 308 SDRLRERRWHLGIPLLMAAAGLSLAALAPTSAWLVMGGLVIAGMGASAALPMFWQLPPAF 367 Query: 370 LSGTAAAAGIALINSLGNLAGFVSPFLVGWLKDTTQSTNAGMYVLAASLVIGGLLTLTLP 429 LS AAGIALI+S G++A F++P+L+GW++DTTQS + +Y+LA + +G L L P Sbjct: 368 LSSATLAAGIALISSFGSIAAFLAPYLIGWMRDTTQSASLALYLLAILIALGAGLVLRTP 427 Query: 430 ARLVN 434 A +VN Sbjct: 428 AAVVN 432 >RSp1572 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 433 Score = 365 bits (936), Expect = e-100, Method: Compositional matrix adjust. Identities = 189/394 (47%), Positives = 249/394 (63%), Gaps = 2/394 (0%) Query: 17 EDATYSKVTWRLLPLLFLCYVASYLDRVNVGFAKLQMLQDLKFSDTVYGLGAGIFFLGYF 76 + YS V R+LP L CY+ +YLDR+N+GFAKLQM DL SD YGLGAGIFF GY Sbjct: 16 STSVYSVVNRRILPFLATCYLFAYLDRINIGFAKLQMQNDLALSDAAYGLGAGIFFFGYM 75 Query: 77 VFEVPSNMILHKVGARLWIARIMITWGIISGAMAYVTTPEMFYIMRFLLGVAEAGFFPGV 136 +FEVPSN++L K+GAR ++RI+I WGI+S +M +VT FY +RFLLGV EAGF PG+ Sbjct: 76 LFEVPSNLLLVKIGARRTLSRILILWGIVSASMLFVTDVWTFYALRFLLGVFEAGFAPGM 135 Query: 137 ILYLTYWYPAARRGKITALFMTGIALSGVIGGPFSGWIMHAMPGVWGHTGWQWMFILEAI 196 I YLT WYP R + A+ + L GVIGGP S WIM G G GWQWMF+ E I Sbjct: 136 IYYLTQWYPGERMARAMAVVLGAAPLGGVIGGPASTWIMGHFAGAGGLAGWQWMFLAEGI 195 Query: 197 PSLVLGVLVILYMKDRIRDAEWLSEDEKRLLEANISHEESQKEHLSLGAMFANGRVWLGA 256 PS++LG+ Y+ D+ DA WL++ +K ++ +I+ + S G ++++ A Sbjct: 196 PSILLGIAAYGYLVDKPADARWLTDAQKAVIAGDIARAAPGQAS-SFGKALTEPKLYVLA 254 Query: 257 LIYFCFVMGLYGVSFWLPTIIKATGVSDPLNVGLLTAIPYAFAAAAMVLIGRSADARRER 316 YFC + G+Y V FWLP+I+K+ G+SD +GL +AIP AM +GR +D R ER Sbjct: 255 AAYFCLICGVYAVGFWLPSILKSAGLSDLFQIGLYSAIPNLAMIVAMYALGRRSDRRGER 314 Query: 317 RWHVAIPAFIGCIGLLLSTLYGHNTALAMASLTLASVGIMTTLPLFWSLPTAFLSGTAAA 376 H AI A +G GLL Y + A+ S+TLAS I + +FW++P L GTAAA Sbjct: 315 HLHSAITAVLGA-GLLAWAAYATSFPAALISITLASAAIFASYSVFWAIPQQHLKGTAAA 373 Query: 377 AGIALINSLGNLAGFVSPFLVGWLKDTTQSTNAG 410 GIALINS+G GF SP L+GW K+ T S AG Sbjct: 374 GGIALINSIGLFGGFFSPTLIGWTKEATGSLQAG 407