BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.2025.p (758 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value BH1126 [V] COG1132 ABC-type multidrug transport system, ATPase a... 381 e-105 DRA0349 [V] COG1132 ABC-type multidrug transport system, ATPase ... 381 e-105 BS_yknV [V] COG1132 ABC-type multidrug transport system, ATPase ... 368 e-101 BS_ygaD [V] COG1132 ABC-type multidrug transport system, ATPase ... 368 e-101 TM0288 [V] COG1132 ABC-type multidrug transport system, ATPase a... 363 1e-99 >BH1126 [V] COG1132 ABC-type multidrug transport system, ATPase and permease components Bha Bacillus halodurans Length = 601 Score = 381 bits (979), Expect = e-105, Method: Compositional matrix adjust. Identities = 217/587 (36%), Positives = 345/587 (58%), Gaps = 22/587 (3%) Query: 163 PSTWA-LFRLSRFAKPYKGSLLLGFLLTLASTAATLVPPYMTMPLMDNVLIPFQNGAPID 221 P WA + RL + KPY SLL ++ + A + +P++ VL ID Sbjct: 21 PFNWAQMMRLLTYMKPYAASLLPKTVVAMLIVTAV----RLFVPIIIGVL-------AID 69 Query: 222 THLATLYLSGLLGAALLAWGLGWARTYI--------LALVSERIGADLRTTTYAHLLRLS 273 +A L+ + A L GL ++ +Y+ + + + + D+R + H+ RLS Sbjct: 70 HAIAAGDLNVMYQLAALVLGL-YSISYVANVFRIRWMNEIGQHVIYDIRADLFNHIQRLS 128 Query: 274 QEYFGGKRTGDLMARIGSETDRICVFLSLHLLDFAIDVLMIIMTAAILISINPWLALVTL 333 +F + G ++ R+ ++ + + + +++ +D+++++ IL S++P LA++ L Sbjct: 129 HRFFDQRSAGSILVRVVNDVNSLQDLFTNGVINLLMDIVILLGIIVILFSLSPELAILIL 188 Query: 334 LPLPFIAWMIHVVRDRLRHGFEKIDRIWSEVTNVLADTIPGIRVVKAFAQEKREVARFRE 393 + LP + ++ +R +R ++ + S++ + L ++I GIRV +AF+QEK + FR+ Sbjct: 189 IVLPIMFFISTKLRRNIRRSWQTVRLRQSKLNSHLNESIQGIRVTQAFSQEKENMRFFRD 248 Query: 394 ANRHNLMVNDRVNKIWSLFTPTVTFLTEVGLLVVWVFGIWQVSSNQITVGVLTAFLAYIS 453 N N ++ +LF P V + +G +V+ +G+ + S +TVGV +F Y+ Sbjct: 249 INEENFQSWKDATRMNALFRPFVEMASAIGAVVLIWYGVSLIQSEVLTVGVFVSFAFYLG 308 Query: 454 RFYTRLDSMSRIVSVTQKAAAGAKRIFDILDHVSSVPEPANPVHLEKVEGAIEVRNIGFR 513 F+ + + ++ + A ++RIF+ LD SVPE N V L ++ G + + F Sbjct: 309 MFWEPISRLGQVYNQLLVGMASSERIFEFLDEKPSVPEKENAVTLHEMRGHVTFEQVEFS 368 Query: 514 YGN-RAVIRNMSLSIAPGEMIGLVGHSGSGKSTMVNLICRFYDVSEGAIRIDGVDIRSLP 572 Y + R + ++S I G+ I LVGH+GSGKST+VNLI RFYD + G I+IDGVD+R + Sbjct: 369 YDDKRKALNDISFEIKAGQTIALVGHTGSGKSTIVNLISRFYDPTAGVIKIDGVDLRDIQ 428 Query: 573 ISEYRRNIGLVLQEPFLFFGTIAENIAYGKPEATREEIIAAARAAHAHEFILRLPQGYDS 632 ++ R N+ VLQ+ F+F GTI ENI +G+P AT EE+ AAA A A++FI RLP GYD+ Sbjct: 429 LNSLRTNVSFVLQDTFIFAGTIMENIRFGRPTATDEEVKAAAEAIGANDFIERLPNGYDT 488 Query: 633 LVGERGQALSGGERQRISIARALLIDPRILILDEATSSVDTTTEKEIQKALDNLVQGRTT 692 V E+G LS GERQ +S ARALL DP+ILILDEAT+S+DT TE +IQ L L+ RT Sbjct: 489 EVEEKGNVLSVGERQLLSFARALLADPKILILDEATASIDTETELKIQAGLKKLLHDRTA 548 Query: 693 IAIAHRLSTLRKADRLVVLDRGQVVEVGNHEELMAREGHYYKLYQAQ 739 I IAHRLST+R AD+++VL++G ++E G H ELM G YY L +AQ Sbjct: 549 IMIAHRLSTIRDADQIIVLEQGDIIEQGTHSELMDARGTYYGLVKAQ 595 >DRA0349 [V] COG1132 ABC-type multidrug transport system, ATPase and permease components Dra Deinococcus radiodurans Length = 602 Score = 381 bits (978), Expect = e-105, Method: Compositional matrix adjust. Identities = 228/577 (39%), Positives = 342/577 (59%), Gaps = 7/577 (1%) Query: 168 LFRLSRFAKPYKGSLLLGFLLTLASTAATLVPPYMTMPLMDNVLIPF--QNGAPIDTHLA 225 L RL +A+PY+ +LG L TL S+ LV P + L+D + + P+D + Sbjct: 25 LRRLLAYARPYRLPFVLGVLATLISSGLGLVFPRLFGTLIDASFLKVGSTDTGPLDRTVL 84 Query: 226 TLYLSGLLGAALLAWGLGWARTYILALVSERIGADLRTTTYAHLLRLSQEYFGGKRTGDL 285 +L LG L+ G A+ Y+LA V + ADLR ++HLL LS +FG RTGDL Sbjct: 85 SL-----LGIFALSACFGAAQAYLLARVGAGVVADLRRALFSHLLSLSPRFFGNHRTGDL 139 Query: 286 MARIGSETDRICVFLSLHLLDFAIDVLMIIMTAAILISINPWLALVTLLPLPFIAWMIHV 345 +R+ S+ + S L A +I + +L+ +P L+L+TL +P + Sbjct: 140 TSRLTSDVGTVQAVTSTALAQLASQGFTLIGSVLLLVQTSPRLSLLTLAIIPLVIGTAVT 199 Query: 346 VRDRLRHGFEKIDRIWSEVTNVLADTIPGIRVVKAFAQEKREVARFREANRHNLMVNDRV 405 + R+R ++ + + I G+RVV++F E E R+ + + R Sbjct: 200 IGRRIRRVSREVQDAVAAANGQAEEAISGVRVVQSFTAEGLEEERYGQGVLASFRAALRR 259 Query: 406 NKIWSLFTPTVTFLTEVGLLVVWVFGIWQVSSNQITVGVLTAFLAYISRFYTRLDSMSRI 465 ++ +L T ++FLT L +V FG QV S +T G L FL Y + + +++ + Sbjct: 260 ARLQALMTGVMSFLTFGALALVLWFGGRQVMSGALTPGNLVTFLFYALQVGGTVAALTGV 319 Query: 466 VSVTQKAAAGAKRIFDILDHVSSVPEPANPVHLEKVEGAIEVRNIGFRYGNRAVIRNMSL 525 + Q+A + RIF++LD S +P PA P L + EG + ++GF Y +++++ Sbjct: 320 FNQFQEALGASSRIFELLDERSDLPGPAAPRPLSRAEGRVRFVDVGFTYAGAPALQDITF 379 Query: 526 SIAPGEMIGLVGHSGSGKSTMVNLICRFYDVSEGAIRIDGVDIRSLPISEYRRNIGLVLQ 585 + G+++ LVG SG+GK+T+VNLI RF+DV+ G + +DG D+R+ +++ RR +GLV Q Sbjct: 380 DVPAGQVVALVGPSGAGKTTLVNLIPRFWDVTAGRVEVDGHDVRAYALADLRRQVGLVPQ 439 Query: 586 EPFLFFGTIAENIAYGKPEATREEIIAAARAAHAHEFILRLPQGYDSLVGERGQALSGGE 645 E LF GT+AENI YG+P A++ E+ AAA AAHAHEFI L GY ++VGERG LSGG+ Sbjct: 440 ETLLFSGTVAENILYGRPGASQAEVEAAAHAAHAHEFICELEGGYGAVVGERGVKLSGGQ 499 Query: 646 RQRISIARALLIDPRILILDEATSSVDTTTEKEIQKALDNLVQGRTTIAIAHRLSTLRKA 705 RQR++IARA+L DPRILILDEATS++D +E +Q AL+ L+ GRTT +AHRLST+R A Sbjct: 500 RQRVAIARAILKDPRILILDEATSALDNESEALVQAALERLMVGRTTFVVAHRLSTIRSA 559 Query: 706 DRLVVLDRGQVVEVGNHEELMAREGHYYKLYQAQARN 742 DR++V+D G+VV G HE LMA G Y +LY+ Q R Sbjct: 560 DRILVMDAGRVVADGTHEGLMAAGGLYRELYELQFRQ 596 >BS_yknV [V] COG1132 ABC-type multidrug transport system, ATPase and permease components Bsu Bacillus subtilis Length = 604 Score = 368 bits (945), Expect = e-101, Method: Compositional matrix adjust. Identities = 208/580 (35%), Positives = 336/580 (57%), Gaps = 8/580 (1%) Query: 163 PSTWA-LFRLSRFAKPYKGSLL-LGFLLTLASTAATLVPPYMTMPLMDNVLIPFQNGAPI 220 P WA ++RL + KPY+ ++L L FL L TA LV +P++ V + Q Sbjct: 24 PFNWAQMWRLLSYVKPYRKTILPLSFLTVLIGTAVKLV-----IPILIGVYVLDQAITGR 78 Query: 221 DTHLATLYLSGLLGAALLAWGLGWARTYILALVSERIGADLRTTTYAHLLRLSQEYFGGK 280 ++ L + + G +L + R + + + + DLR + H+ RLS +F + Sbjct: 79 NSELLIQLIFIISGLYVLNYAANVLRIRWMNQLGQHVIYDLRQHLFTHVQRLSHRFFDQR 138 Query: 281 RTGDLMARIGSETDRICVFLSLHLLDFAIDVLMIIMTAAILISINPWLALVTLLPLPFIA 340 G ++ RI ++ + + + +++ D+L++ IL +++P L + ++ LP + Sbjct: 139 SAGSILVRIMNDINSLQELFTSGVINLLTDLLLLAGVIIILFTLSPELTIAIMVTLPIMF 198 Query: 341 WMIHVVRDRLRHGFEKIDRIWSEVTNVLADTIPGIRVVKAFAQEKREVARFREANRHNLM 400 ++ +R ++R ++ + S++ + L ++I GIRV +AF QE+ +A F N+ N Sbjct: 199 FISTSLRKKIRRSWQTVRLKQSKLNSHLNESIQGIRVTQAFTQEEENMAYFDGVNQENYE 258 Query: 401 VNDRVNKIWSLFTPTVTFLTEVGLLVVWVFGIWQVSSNQITVGVLTAFLAYISRFYTRLD 460 + ++F P V +G V+ +G + + IT+GV +F Y+ F+ + Sbjct: 259 SWREATRKNAMFRPLVEMTNAIGTAVLIWYGATLIMNETITIGVFVSFAFYLGMFWEPIS 318 Query: 461 SMSRIVSVTQKAAAGAKRIFDILDHVSSVPEPANPVHLEKVEGAIEVRNIGFRYG-NRAV 519 + ++ + A ++RIF+ LD +V E N +H EK+ G I + F Y R Sbjct: 319 RLGQVYNQLLMGMASSERIFEFLDEQPNVKEKPNAIHNEKINGEISFEEVEFSYDEKRKA 378 Query: 520 IRNMSLSIAPGEMIGLVGHSGSGKSTMVNLICRFYDVSEGAIRIDGVDIRSLPISEYRRN 579 + +S SI G + LVGH+GSGK+T+ NLI RFYD + G I+IDG+ I+ L ++ R Sbjct: 379 LHAVSFSIPAGSTLALVGHTGSGKTTIANLISRFYDAAGGTIKIDGIPIKDLSLASLRSQ 438 Query: 580 IGLVLQEPFLFFGTIAENIAYGKPEATREEIIAAARAAHAHEFILRLPQGYDSLVGERGQ 639 I +VLQ+ F+F GTI ENI +G+P A+ EE++ A++A A EFI L +GY + V ERG Sbjct: 439 ISIVLQDTFIFSGTIMENIRFGRPNASDEEVMKASQAVGADEFISDLAEGYATEVEERGS 498 Query: 640 ALSGGERQRISIARALLIDPRILILDEATSSVDTTTEKEIQKALDNLVQGRTTIAIAHRL 699 LS G+RQ IS ARALL DP I+ILDEAT+S+DT TE +IQ+AL L++GRT + IAHRL Sbjct: 499 VLSAGQRQLISFARALLADPAIIILDEATASIDTETEVKIQQALKTLLKGRTAVMIAHRL 558 Query: 700 STLRKADRLVVLDRGQVVEVGNHEELMAREGHYYKLYQAQ 739 ST+R ADR++VLD G+ +E GNH++L+A+ G Y L +AQ Sbjct: 559 STIRDADRIIVLDHGRKIEEGNHDQLLAKGGIYAGLVKAQ 598 >BS_ygaD [V] COG1132 ABC-type multidrug transport system, ATPase and permease components Bsu Bacillus subtilis Length = 589 Score = 368 bits (944), Expect = e-101, Method: Compositional matrix adjust. Identities = 202/590 (34%), Positives = 339/590 (57%), Gaps = 10/590 (1%) Query: 159 KEAPPSTWALFRLSRFAKPYKGSLLLGFLLTLASTAATLVPPYMTMPLMDNVLIPFQNGA 218 +E + + R +F KPYK + + L+ + + L P + ++D+++ Q G Sbjct: 4 REGESTVGVMKRYMQFVKPYKKQIFVTVLIGIVKFSIPLALPLLLKYVVDDII---QGGG 60 Query: 219 PIDTHLATLY-LSGLLGAALLAWG--LGWARTYILALVSERIGADLRTTTYAHLLRLSQE 275 +L+ + ++ A L + + R Y + ++ D+R + H+ +LS Sbjct: 61 TASDKTTSLFTIMAIMFALFLILRPPVEYYRQYFAQWTASKVLYDIRAKLFDHIQKLSLR 120 Query: 276 YFGGKRTGDLMARIGSETDRICVFLSLHLLDFAIDVLMIIMTAAILISINPWLALVTLLP 335 ++ RTG++++R+ ++ ++ F+ L++ +D+L I++ +I+++++ L L++++ Sbjct: 121 FYANTRTGEVISRVINDVEQTKDFVITGLMNIWLDMLTILIVISIMLTLDVKLTLISIVL 180 Query: 336 LPFIAWMIHVVRDRLRHGFEKIDRIWSEVTNVLADTIPGIRVVKAFAQEKREVARFREAN 395 P + RLR + + ++V L + I G+ V+++FA E E A+F E N Sbjct: 181 FPLYGISVKYFYGRLRKLTRERSQALAQVQGHLHERIQGMPVIRSFAIEDHEQAQFNEKN 240 Query: 396 RHNLMVNDRVNKIWSLFT-PTVTFLTEVGLLVVWVFGIWQVSSNQITVGVLTAFLAYISR 454 H L R W+ T V +T++ L+V + V + +TVG + AF+ YI R Sbjct: 241 GHFLDKAIRHTN-WNAKTFAVVNTITDLAPLIVIACAGYFVINGPLTVGTMVAFVGYIDR 299 Query: 455 FYTRLDSMSRIVSVTQKAAAGAKRIFDILDHVSSVPEPANPVHLEKVEGAIEVRNIGFRY 514 Y + + + ++ A R+F+ +D + + N + +++ G +E +N+ F+Y Sbjct: 300 MYNPVRRLINSSTTLTQSIASMDRVFEFIDEPYELTDKPNAIKADQIRGGVEFQNVSFQY 359 Query: 515 --GNRAVIRNMSLSIAPGEMIGLVGHSGSGKSTMVNLICRFYDVSEGAIRIDGVDIRSLP 572 ++ ++SL + GE + LVG SG GKST+V+LI RFYDV+ G + IDG DIR Sbjct: 360 EKDKENILHDVSLKVNRGETVALVGMSGGGKSTLVSLIPRFYDVTSGRLLIDGTDIRDYE 419 Query: 573 ISEYRRNIGLVLQEPFLFFGTIAENIAYGKPEATREEIIAAARAAHAHEFILRLPQGYDS 632 R +G+VLQ+ FLF TI ENIA GKP+AT EEII AA+AA+AHEFI+ P+GY++ Sbjct: 420 ARSLRNQVGMVLQDTFLFSETIRENIAIGKPDATLEEIIEAAKAANAHEFIMSFPEGYET 479 Query: 633 LVGERGQALSGGERQRISIARALLIDPRILILDEATSSVDTTTEKEIQKALDNLVQGRTT 692 VGERG LSGG++QRISIAR L +P +LILDEATS++D +E IQ+A+D L + RTT Sbjct: 480 RVGERGVKLSGGQKQRISIARVFLKNPPLLILDEATSALDLESEHYIQEAMDKLAKDRTT 539 Query: 693 IAIAHRLSTLRKADRLVVLDRGQVVEVGNHEELMAREGHYYKLYQAQARN 742 +AHRLST+ AD++VV++ G ++E+G H+ELM E Y L+ Q N Sbjct: 540 FVVAHRLSTITHADKIVVMENGTIIEIGTHDELMDYESQYKHLFTIQNLN 589 >TM0288 [V] COG1132 ABC-type multidrug transport system, ATPase and permease components Tma Thermotoga maritima Length = 598 Score = 363 bits (931), Expect = 1e-99, Method: Compositional matrix adjust. Identities = 199/576 (34%), Positives = 331/576 (57%), Gaps = 8/576 (1%) Query: 165 TWALFRLSRFAKPYKGSLLLGFLLTLASTAATLVPPYMTMPLMDNVLIPFQNGAPIDTHL 224 T L RL + +P+ +L++ F+ S+ ++ PY+ +D V +P + L Sbjct: 22 TATLRRLLGYLRPHTFTLIMVFVFVTVSSILGVLSPYLIGKTIDVVFVPRR------FDL 75 Query: 225 ATLYLSGLLGAALLAWGLGWARTYILALVSERIGADLRTTTYAHLLRLSQEYFGGKRTGD 284 Y+ L L L W + I+ +S+ + LR + L R+ +F GD Sbjct: 76 LPRYMLILGTIYALTSLLFWLQGKIMLTLSQDVVFRLRKELFEKLQRVPVGFFDRTPHGD 135 Query: 285 LMARIGSETDRICVFLSLHLLDFAIDVLMIIMTAAILISINPWLALVTLLPLPFIAWMIH 344 +++R+ ++ D I L ++ F ++ + ++ +N L+LVTL +P + Sbjct: 136 IISRVINDVDNINNVLGNSIIQFFSGIVTLAGAVIMMFRVNVILSLVTLSIVPLTVLITQ 195 Query: 345 VVRDRLRHGFEKIDRIWSEVTNVLADTIPGIRVVKAFAQEKREVARFREANRHNLMVNDR 404 +V + R F + R+ ++ ++ + I G+ V+K F +E++E+ +F N V + Sbjct: 196 IVSSQTRKYFYENQRVLGQLNGIIEEDISGLTVIKLFTREEKEMEKFDRVNESLRKVGTK 255 Query: 405 VNKIWSLFTPTVTFLTEVGLLVVWVFGIWQVSSNQITVGVLTAFLAYISRFYTRLDSMSR 464 + P + + +G ++ FG W + ITVG + F+ Y +F L+ +S Sbjct: 256 AQIFSGVLPPLMNMVNNLGFALISGFGGWLALKDIITVGTIATFIGYSRQFTRPLNELSN 315 Query: 465 IVSVTQKAAAGAKRIFDILDHVSSVPEPANPVHLEKVEGAIEVRNIGFRYGNRA-VIRNM 523 ++ Q A A A+RIF+ILD +P + V L +V G IE +N+ F Y + V++++ Sbjct: 316 QFNMIQMALASAERIFEILDLEEEKDDP-DAVELREVRGEIEFKNVWFSYDKKKPVLKDI 374 Query: 524 SLSIAPGEMIGLVGHSGSGKSTMVNLICRFYDVSEGAIRIDGVDIRSLPISEYRRNIGLV 583 + I PG+ + LVG +GSGK+T+VNL+ RFYDV G I +DG+DIR + S R +IG+V Sbjct: 375 TFHIKPGQKVALVGPTGSGKTTIVNLLMRFYDVDRGQILVDGIDIRKIKRSSLRSSIGIV 434 Query: 584 LQEPFLFFGTIAENIAYGKPEATREEIIAAARAAHAHEFILRLPQGYDSLVGERGQALSG 643 LQ+ LF T+ EN+ YG P AT EEI AA+ H+ FI LP+GY++++ + G+ LS Sbjct: 435 LQDTILFSTTVKENLKYGNPGATDEEIKEAAKLTHSDHFIKHLPEGYETVLTDNGEDLSQ 494 Query: 644 GERQRISIARALLIDPRILILDEATSSVDTTTEKEIQKALDNLVQGRTTIAIAHRLSTLR 703 G+RQ ++I RA L +P+ILILDEATS+VDT TEK IQ A+ L++G+T+I IAHRL+T++ Sbjct: 495 GQRQLLAITRAFLANPKILILDEATSNVDTKTEKSIQAAMWKLMEGKTSIIIAHRLNTIK 554 Query: 704 KADRLVVLDRGQVVEVGNHEELMAREGHYYKLYQAQ 739 AD ++VL G++VE+G H+EL+ + G YY+L+ +Q Sbjct: 555 NADLIIVLRDGEIVEMGKHDELIQKRGFYYELFTSQ 590