BLASTP 2.2.21 [Jun-14-2009]

Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Reference for compositional score matrix adjustment: Altschul, Stephen F., 
John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis,
Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches
using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.

Query= 0001.1976.p         (204 letters)

Database: COGmodified 
           192,987 sequences; 59,019,183 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

RSc1604 Non COG                                                        84   2e-16
AGl450 Non COG                                                         37   0.035
SP1161 [C] COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex...    33   0.33 
SPy1031_2 [C] COG1249 Pyruvate/2-oxoglutarate dehydrogenase comp...    31   1.5  
Rv2139 [F] COG0167 Dihydroorotate dehydrogenase Mtu Mycobacteriu...    29   6.2  

>RSc1604 Non COG
          Length = 185

 Score = 84.0 bits (206), Expect = 2e-16,   Method: Compositional matrix adjust.
 Identities = 57/152 (37%), Positives = 82/152 (53%), Gaps = 8/152 (5%)

Query: 32  LEEWLWDATQALLARIPDWPLLVRLQRWVERLSPYAALMIFLAPTLLLLPVKILALLSIT 91
            EEW+W+A     AR+   P +   +R +  L P  AL  F+ P L LLP K+ A+  + 
Sbjct: 21  FEEWIWNAMLRATARLVAHPWVQAAERRMAELEPIEALCAFVLPMLALLPFKLAAVYMLA 80

Query: 92  HGHPTLGLLIVLSAKVLGTALVARIYALTRRSLLSLPWFVRYHDRLLAFKARLTAQLQAT 151
            GH   G  +++ AKV+ T L ARIY + R  L  + W+VR   R L +K R+ A L+AT
Sbjct: 81  RGHFLGGAAVLVLAKVVSTTLGARIYVVVRPQLQQISWYVRLESRFLDWKHRVVAALRAT 140

Query: 152 AGWQQVQ------RLVRS--VRQGLARVKSVL 175
             WQ +Q      R+ R   +RQG  R+ +VL
Sbjct: 141 PTWQALQARLAAWRVQRHGLLRQGWRRLVAVL 172


>AGl450 Non COG
          Length = 186

 Score = 36.6 bits (83), Expect = 0.035,   Method: Compositional matrix adjust.
 Identities = 30/104 (28%), Positives = 48/104 (46%), Gaps = 3/104 (2%)

Query: 47  IPDWPLLVRLQRWVERLSPYAALMIFLAPTLLLLPVKILALLSITHGHPTLGLLIVLSAK 106
           I +   + RL+  + +L   A L+    P  +  P+K++ L+ I HG    G+ + + A 
Sbjct: 71  ISNLTFIRRLENRIAQLPRLAILLCLAVPFAIAEPMKVVGLVLIAHGAFKSGVALTILAH 130

Query: 107 VLGTALVARIYALTRRSLLS---LPWFVRYHDRLLAFKARLTAQ 147
           +    +V RIY   R  LL+   L W +RY     AF  R  A 
Sbjct: 131 LSTFLIVERIYHAGREKLLTYGWLAWIMRYVRFARAFYDRAKAS 174


>SP1161 [C] COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex,
           dihydrolipoamide dehydrogenase (E3) component, and
           related enzymes Spn Streptococcus pneumoniae TIGR4
          Length = 567

 Score = 33.5 bits (75), Expect = 0.33,   Method: Compositional matrix adjust.
 Identities = 23/76 (30%), Positives = 37/76 (48%), Gaps = 3/76 (3%)

Query: 38  DATQALLARIPDWPLLVRLQRWVERLSPYAALMIFLAPTLLLLPVKILALLSITHGHPTL 97
           DA Q  +  I D      L   V  + P AA +I  A +++ + + +  +L   HGHPT 
Sbjct: 488 DAAQGFVKVIADKKYGEIL--GVHIIGPAAAELINEASSIIEMEITVEEMLKTIHGHPTY 545

Query: 98  GLLIVLS-AKVLGTAL 112
             ++  + A VLG A+
Sbjct: 546 SEVMYEAFADVLGMAI 561


>SPy1031_2 [C] COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex,
           dihydrolipoamide dehydrogenase (E3) component, and
           related enzymes Spy Streptococcus pyogenes M1 GAS
          Length = 460

 Score = 31.2 bits (69), Expect = 1.5,   Method: Compositional matrix adjust.
 Identities = 20/55 (36%), Positives = 29/55 (52%), Gaps = 1/55 (1%)

Query: 59  WVERLSPYAALMIFLAPTLLLLPVKILALLSITHGHPTLGLLIVLS-AKVLGTAL 112
            V  + P AA MI  A T++   + +  LL   HGHPT   ++  + A VLG A+
Sbjct: 399 GVHIIGPAAAEMINEAATIMESELTVDELLLSIHGHPTFSEVMYEAFADVLGEAI 453


>Rv2139 [F] COG0167 Dihydroorotate dehydrogenase Mtu Mycobacterium
           tuberculosis H37Rv
          Length = 357

 Score = 29.3 bits (64), Expect = 6.2,   Method: Compositional matrix adjust.
 Identities = 24/67 (35%), Positives = 32/67 (47%), Gaps = 8/67 (11%)

Query: 140 FKARLTAQLQATAGWQQVQRLVRS---VRQGLARVKSVLAQRMVAQPGGPATRLLRLL-- 194
           F  R  A L   AG+ +    + S   +  G A + +V A     QPG PA RL RL   
Sbjct: 54  FGVRFPAPLGLAAGFDKDGTALSSWGAMGFGYAEIGTVTAH---PQPGNPAPRLFRLADD 110

Query: 195 RRLVSRM 201
           R L++RM
Sbjct: 111 RALLNRM 117