BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.1868.p (426 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PM0524 [R] COG1778 Low specificity phosphatase (HAD superfamily)... 207 3e-53 HI1679 [R] COG1778 Low specificity phosphatase (HAD superfamily)... 201 3e-51 VC1875 [M] COG1212 CMP-2-keto-3-deoxyoctulosonic acid synthetase... 199 1e-50 FN0807 [M] COG1212 CMP-2-keto-3-deoxyoctulosonic acid synthetase... 197 4e-50 YPO1400 [M] COG1212 CMP-2-keto-3-deoxyoctulosonic acid synthetas... 191 2e-48 >PM0524 [R] COG1778 Low specificity phosphatase (HAD superfamily) Pmu Pasteurella multocida Length = 181 Score = 207 bits (528), Expect = 3e-53, Method: Compositional matrix adjust. Identities = 102/179 (56%), Positives = 123/179 (68%) Query: 248 TGSLADVKLVITDIDGVLTDGGIWYDDSGECLKRFHVRDGMGIKMLQEAGVNVAVISGRD 307 T L +K VITDIDGVLTDG + YD GE K FHVRDG+GI+ML E+G+ VAV+SGRD Sbjct: 3 TEKLKKIKFVITDIDGVLTDGSLHYDAHGEAFKTFHVRDGLGIRMLMESGIQVAVLSGRD 62 Query: 308 SATLRRRLADLGITVFQLGAKDKAGACRAIMEQFQVGPEATAMIGDDSIDLPGFAACAWP 367 S LR+R+ADLGI F LG +K AC +++Q V + TA IGDDS+DLP FA C Sbjct: 63 SPILRKRIADLGIQHFFLGKLEKESACLELIQQANVCAQETAYIGDDSVDLPAFAVCGVA 122 Query: 368 VAVDDAPDYVKRHARVVLTKAGGQGAFREFSDSVLNAQNRSAIYDSVAGYAQAMSRMAQ 426 AV DAP Y+K HA VL GGQGAFRE SD +L AQN+S IY S G+ +A +M Q Sbjct: 123 FAVQDAPAYIKMHADHVLILKGGQGAFREMSDMILAAQNKSDIYTSAQGFLKAAKKMTQ 181 >HI1679 [R] COG1778 Low specificity phosphatase (HAD superfamily) Hin Haemophilus influenzae Length = 180 Score = 201 bits (510), Expect = 3e-51, Method: Compositional matrix adjust. Identities = 98/176 (55%), Positives = 126/176 (71%) Query: 251 LADVKLVITDIDGVLTDGGIWYDDSGECLKRFHVRDGMGIKMLQEAGVNVAVISGRDSAT 310 L ++K VITD+DGVLTDG + YD +GE +K FHVRDG+GIKML +A + VAV+SGRDS Sbjct: 5 LENIKFVITDVDGVLTDGQLHYDANGEAIKSFHVRDGLGIKMLMDADIQVAVLSGRDSPI 64 Query: 311 LRRRLADLGITVFQLGAKDKAGACRAIMEQFQVGPEATAMIGDDSIDLPGFAACAWPVAV 370 LRRR+ADLGI +F LG +K AC +M+Q V E TA IGDDS+DLP FAAC AV Sbjct: 65 LRRRIADLGIKLFFLGKLEKETACFDLMKQAGVTAEQTAYIGDDSVDLPAFAACGTSFAV 124 Query: 371 DDAPDYVKRHARVVLTKAGGQGAFREFSDSVLNAQNRSAIYDSVAGYAQAMSRMAQ 426 DAP YVK VL+ GG+GAFRE SD +L AQ +S+++D+ G+ +++ M Q Sbjct: 125 ADAPIYVKNAVDHVLSTHGGKGAFREMSDMILQAQGKSSVFDTAQGFLKSVKSMGQ 180 >VC1875 [M] COG1212 CMP-2-keto-3-deoxyoctulosonic acid synthetase Vch Vibrio cholerae Length = 252 Score = 199 bits (506), Expect = 1e-50, Method: Compositional matrix adjust. Identities = 119/250 (47%), Positives = 156/250 (62%), Gaps = 13/250 (5%) Query: 1 MHCIAVIPARFGSSRLPGKPLADILGKPMIQHVYERVRSLDELAD-VVVATDDERIVAAV 59 M VIPAR+ S+RLPGKPLADI GKPMIQ VYE+ ++ AD V++ATDDER+ AV Sbjct: 1 MSFTVVIPARYQSTRLPGKPLADIGGKPMIQWVYEQ--AMQAGADRVIIATDDERVEQAV 58 Query: 60 NAFGGKALLTSPHHPSGTDRLREVMQHH--PAD-LYLNVQGDEPLVNPTHLRSLLQAMLA 116 AFGG +TSP+H SGT+RL EV+ PAD + +NVQGDEPL+ P +R + + A Sbjct: 59 QAFGGVVCMTSPNHQSGTERLAEVVAKMAIPADHIVVNVQGDEPLIPPAIIRQVADNLAA 118 Query: 117 APQVQAGTLCHAITAGEAENPNTVKVVRNRAGDALYFSRARIPFERESSGKAR------Y 170 A E NPN VKV+ +++G ALYFSRA IP++R++ KA Sbjct: 119 CSAPMATLAVEIEDEAEVFNPNAVKVITDKSGYALYFSRATIPWDRDNFAKADKAIVQPL 178 Query: 171 FKHIGVYAYRAELLAAFPGLPPSELEGAEMLEQLRIMDAGWQIRVIEVDHAAP-GVDTPA 229 +HIG+YAYRA + + PS+LE E LEQLR++ G +I V A P GVDTP Sbjct: 179 LRHIGIYAYRAGFINTYLDWQPSQLEKIECLEQLRVLWHGEKIHVAVALEAPPAGVDTPE 238 Query: 230 CLERVRALMS 239 LE VR +++ Sbjct: 239 DLEVVRRIVA 248 >FN0807 [M] COG1212 CMP-2-keto-3-deoxyoctulosonic acid synthetase Fnu Fusobacterium nucleatum Length = 245 Score = 197 bits (501), Expect = 4e-50, Method: Compositional matrix adjust. Identities = 99/236 (41%), Positives = 149/236 (63%), Gaps = 4/236 (1%) Query: 1 MHCIAVIPARFGSSRLPGKPLADILGKPMIQHVYERVRSLDELADVVVATDDERIVAAVN 60 M + +IPAR+ S+RL GKPL I G MI+ VY+R + + L ++VATDDERI V Sbjct: 1 MKFLGIIPARYSSTRLEGKPLKMIEGHTMIEWVYKRAKKSN-LDSLIVATDDERIYNEVI 59 Query: 61 AFGGKALLTSPHHPSGTDRLREVMQHHPA-DLYLNVQGDEPLVNPTHLRSLLQAMLAAPQ 119 FGG+A++TS +H +GT R+ EV + D +N+QGDEPL+ + SL++ Sbjct: 60 NFGGQAIMTSKNHTNGTSRIAEVCEKMTEYDTIINIQGDEPLIEYEMINSLIETFKENKD 119 Query: 120 VQAGTLCHAI-TAGEAENPNTVKVVRNRAGDALYFSRARIPFERESSGKARYFKHIGVYA 178 ++ TL H + E +NPN VKVV ++ A+YFSR+ IP+ R++ G YFKHIG+Y Sbjct: 120 LKMATLKHKLLNKEEIKNPNNVKVVCDKNDYAIYFSRSVIPYPRKN-GNISYFKHIGIYG 178 Query: 179 YRAELLAAFPGLPPSELEGAEMLEQLRIMDAGWQIRVIEVDHAAPGVDTPACLERV 234 Y+ + + + + + LE E LEQLR+++ G++I+V+E H+ GVDT LE+V Sbjct: 179 YKRDFVIEYSKMLATPLEEIESLEQLRVLENGYKIKVLETTHSLIGVDTQENLEQV 234 >YPO1400 [M] COG1212 CMP-2-keto-3-deoxyoctulosonic acid synthetase Ype Yersinia pestis Length = 250 Score = 191 bits (485), Expect = 2e-48, Method: Compositional matrix adjust. Identities = 118/249 (47%), Positives = 156/249 (62%), Gaps = 13/249 (5%) Query: 1 MHCIAVIPARFGSSRLPGKPLADILGKPMIQHVYERVRSLDELAD-VVVATDDERIVAAV 59 M IA+IPAR+ S+RLPGKPLADI GKPM+ HV ER +L AD V+VATD +V AV Sbjct: 1 MSFIAIIPARYASTRLPGKPLADIAGKPMVVHVMER--ALASGADRVIVATDHPDVVKAV 58 Query: 60 NAFGGKALLTSPHHPSGTDRLREVMQHH---PADLYLNVQGDEPLVNPTHLRSLLQAMLA 116 A GG+ LT H SGT+RL EV++H+ D+ +NVQGDEPLV P +R + + A Sbjct: 59 EAAGGEVCLTRADHQSGTERLAEVIEHYGFADDDIIVNVQGDEPLVPPVIIRQVADNLAA 118 Query: 117 APQVQAGTLCHAITAGEAENPNTVKVVRNRAGDALYFSRARIPFERESSGKAR------Y 170 A ++ EA NPN VKVV + G ALYFSRA IP+ERE +++ + Sbjct: 119 CSAGMATLAVPIASSEEAFNPNAVKVVMDAQGYALYFSRATIPWERERFAQSKETIGDCF 178 Query: 171 FKHIGVYAYRAELLAAFPGLPPSELEGAEMLEQLRIMDAGWQIR-VIEVDHAAPGVDTPA 229 +HIG+YAYRA + + PS+LE E+LEQLR++ G +I + A GVDT + Sbjct: 179 LRHIGIYAYRAGFIRRYVNWAPSQLEQIELLEQLRVLWYGEKIHVAVAKAVPAVGVDTQS 238 Query: 230 CLERVRALM 238 L+RVRA+M Sbjct: 239 DLDRVRAIM 247