BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.1542.p (456 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value YPO1712 [GEPR] COG0477 Permeases of the major facilitator superf... 387 e-107 yebQ [GEPR] COG0477 Permeases of the major facilitator superfami... 385 e-107 Z2875 [GEPR] COG0477 Permeases of the major facilitator superfam... 384 e-106 ECs2538 [GEPR] COG0477 Permeases of the major facilitator superf... 384 e-106 STM1843 [GEPR] COG0477 Permeases of the major facilitator superf... 381 e-105 >YPO1712 [GEPR] COG0477 Permeases of the major facilitator superfamily Ype Yersinia pestis Length = 455 Score = 387 bits (993), Expect = e-107, Method: Compositional matrix adjust. Identities = 225/449 (50%), Positives = 290/449 (64%), Gaps = 8/449 (1%) Query: 12 TNHDGLPPRQRLLAIATVVLGLSIAVLDGSIANLALPLMAADLKASDADAIWVINSYQIA 71 + DGLP QR AI + LG+ +AVLDG+IAN+ALP +A DL S A +IWV+N+YQ+A Sbjct: 4 STSDGLPVPQRYAAILVIALGIMMAVLDGTIANVALPTIARDLNTSPATSIWVVNAYQLA 63 Query: 72 MAVCLLPLASLGEVIGYRRVYLGGVFLFTLASLACAASGDMLQLSLARVLQGLGAAGILS 131 + + LL +ASLG++IGYRRVY G+ +F++ SL CA S + L+ ARVLQG GAA ++S Sbjct: 64 ITISLLSMASLGDIIGYRRVYQAGLLIFSVTSLFCALSDSLWTLTFARVLQGFGAAALMS 123 Query: 132 VNTALIRFIYPSRLLGRAIGYNALVAGTGNALGPTVAGLILHLATWHWLFLINIPLGLAA 191 VNTALIR IYP LGR IG N L+ +A GP++A +L +A+W WLF +N+P+GL A Sbjct: 124 VNTALIRIIYPRAQLGRGIGINTLIVAVSSAAGPSIAAAVLSVASWQWLFALNVPIGLLA 183 Query: 192 LAVGHRALPTNPLSA--RPFDRQSALLCMCFIGLLLYTIDAVGHLQGAWVVGGCTV-LTA 248 +G + LP N + FD S +L GLL+ I Q V+ V L Sbjct: 184 WCLGIKFLPANNTKSNGNRFDITSCVLNALTFGLLITAISGFSQGQSPAVIAAQVVALLL 243 Query: 249 ISLVLLLRLQSSSAPMLPLDLLRIPLFALSIGTSFCSFAAQMAVFVMLPFMLQNQQGMSV 308 I + R + S P+LP+DLLRIP+FALSIGTS SFAAQM V LPF LQ G Sbjct: 244 IGFFFVRRQLTQSFPLLPVDLLRIPIFALSIGTSIFSFAAQMLAMVSLPFFLQTVLGRDE 303 Query: 309 ARAGLLLTAWPIAVALTGVMAGKLSDRIAAGLLGGIGLAVMCLGLLSLLLVQPGTPDGV- 367 GLLLT WP+A + +AG+L +R AGLLGGIGLAV GL LL V P P V Sbjct: 304 VATGLLLTPWPLATMVIAPIAGRLVERYHAGLLGGIGLAVFASGLF-LLAVLPANPSDVD 362 Query: 368 MVAMFALCGVGFGLFQTPNNRTMISAAPRERTGGASGMLGTARLTGQTVGASVVAMLLAL 427 ++ LCG GFGLFQTPNN T+ISAAP+ R+GGASGMLGTARL GQT GA++VA++ + Sbjct: 363 IIWRMILCGAGFGLFQTPNNHTIISAAPQHRSGGASGMLGTARLLGQTSGAALVALMFNM 422 Query: 428 --SNAPYALVLWCAAALAGAACLVSLWRL 454 +N +A ++ A A A LVSL R+ Sbjct: 423 FSTNGTHASLI-LAGCFASIAALVSLLRV 450 >yebQ [GEPR] COG0477 Permeases of the major facilitator superfamily Eco Escherichia coli K12 Length = 494 Score = 385 bits (990), Expect = e-107, Method: Compositional matrix adjust. Identities = 210/414 (50%), Positives = 282/414 (68%), Gaps = 3/414 (0%) Query: 15 DGLPPRQRLLAIATVVLGLSIAVLDGSIANLALPLMAADLKASDADAIWVINSYQIAMAV 74 DGLP QR AI T+V+G+S+AVLDG+IAN+ALP +A DL A+ A +IWV+N+YQIA+ + Sbjct: 44 DGLPLPQRYGAILTIVIGISMAVLDGAIANVALPTIATDLHATPASSIWVVNAYQIAIVI 103 Query: 75 CLLPLASLGEVIGYRRVYLGGVFLFTLASLACAASGDMLQLSLARVLQGLGAAGILSVNT 134 LL + LG++ GYRR+Y G+ +F L+SL CA S + L+LARV+QG G A ++SVNT Sbjct: 104 SLLSFSFLGDMFGYRRIYKCGLVVFLLSSLFCALSDSLQMLTLARVIQGFGGAALMSVNT 163 Query: 135 ALIRFIYPSRLLGRAIGYNALVAGTGNALGPTVAGLILHLATWHWLFLINIPLGLAALAV 194 ALIR IYP R LGR +G N+ + +A GPT+A IL +A+W WLFLIN+PLG+ AL + Sbjct: 164 ALIRLIYPQRFLGRGMGINSFIVAVSSAAGPTIAAAILSIASWKWLFLINVPLGIIALLL 223 Query: 195 GHRALPTN-PLSARP-FDRQSALLCMCFIGLLLYTIDAVGHLQGAWVVGGCTVLTAISLV 252 R LP N +++P FD SA++ GLL+ + Q ++ V+ + + Sbjct: 224 AMRFLPPNGSRASKPRFDLPSAVMNALTFGLLITALSGFAQGQSLTLIAAELVVMVVVGI 283 Query: 253 LLLRLQ-SSSAPMLPLDLLRIPLFALSIGTSFCSFAAQMAVFVMLPFMLQNQQGMSVARA 311 +R Q S P+LP+DLLRIPLF+LSI TS CSF AQM V LPF LQ G S Sbjct: 284 FFIRRQLSLPVPLLPVDLLRIPLFSLSICTSVCSFCAQMLAMVSLPFYLQTVLGRSEVET 343 Query: 312 GLLLTAWPIAVALTGVMAGKLSDRIAAGLLGGIGLAVMCLGLLSLLLVQPGTPDGVMVAM 371 GLLLT WP+A + +AG L +R+ AGLLG +GL +M GL SL+L+ D ++ Sbjct: 344 GLLLTPWPLATMVMAPLAGYLIERVHAGLLGALGLFIMAAGLFSLVLLPASPADINIIWP 403 Query: 372 FALCGVGFGLFQTPNNRTMISAAPRERTGGASGMLGTARLTGQTVGASVVAMLL 425 LCG GFGLFQ+PNN T+I++APRER+GGASGMLGTARL GQ+ GA++VA++L Sbjct: 404 MILCGAGFGLFQSPNNHTIITSAPRERSGGASGMLGTARLLGQSSGAALVALML 457 >Z2875 [GEPR] COG0477 Permeases of the major facilitator superfamily EcZ Escherichia coli O157:H7 EDL933 Length = 494 Score = 384 bits (987), Expect = e-106, Method: Compositional matrix adjust. Identities = 210/414 (50%), Positives = 282/414 (68%), Gaps = 3/414 (0%) Query: 15 DGLPPRQRLLAIATVVLGLSIAVLDGSIANLALPLMAADLKASDADAIWVINSYQIAMAV 74 DGLP QR AI T+V+G+S+AVLDG+IAN+ALP +A DL A+ A +IWV+N+YQIA+ + Sbjct: 44 DGLPLPQRYGAILTIVIGISMAVLDGAIANVALPTIATDLHATPASSIWVVNAYQIAIVI 103 Query: 75 CLLPLASLGEVIGYRRVYLGGVFLFTLASLACAASGDMLQLSLARVLQGLGAAGILSVNT 134 LL + LG++ GYRR+Y G+ +F L+SL CA S + L+LARV+QG G A ++SVNT Sbjct: 104 SLLSFSFLGDMFGYRRIYKCGLVVFLLSSLFCALSDSLQILTLARVIQGFGGAALMSVNT 163 Query: 135 ALIRFIYPSRLLGRAIGYNALVAGTGNALGPTVAGLILHLATWHWLFLINIPLGLAALAV 194 ALIR IYP R LGR +G N+ + +A GPT+A IL +A+W WLFLIN+PLG+ AL + Sbjct: 164 ALIRLIYPQRFLGRGMGINSFIVAVSSAAGPTIAAAILSIASWKWLFLINVPLGIIALLL 223 Query: 195 GHRALPTN-PLSARP-FDRQSALLCMCFIGLLLYTIDAVGHLQGAWVVGGCTVLTAISLV 252 R LP N +++P FD SA++ GLL+ + Q ++ V+ + + Sbjct: 224 AMRFLPPNGSRASKPRFDLPSAVMNALTFGLLITALSGFAQGQSLTLIAAELVVMVVVGI 283 Query: 253 LLLRLQ-SSSAPMLPLDLLRIPLFALSIGTSFCSFAAQMAVFVMLPFMLQNQQGMSVARA 311 +R Q S P+LP+DLLRIPLF+LSI TS CSF AQM V LPF LQ G S Sbjct: 284 FFIRRQLSLPVPLLPVDLLRIPLFSLSICTSVCSFCAQMLAMVSLPFYLQTVLGRSEVET 343 Query: 312 GLLLTAWPIAVALTGVMAGKLSDRIAAGLLGGIGLAVMCLGLLSLLLVQPGTPDGVMVAM 371 GLLLT WP+A + +AG L +R+ AGLLG +GL +M GL SL+L+ D ++ Sbjct: 344 GLLLTPWPLATMVMAPLAGYLIERVHAGLLGALGLFIMAAGLFSLVLLPASPADINIIWP 403 Query: 372 FALCGVGFGLFQTPNNRTMISAAPRERTGGASGMLGTARLTGQTVGASVVAMLL 425 LCG GFGLFQ+PNN T+I++APRER+GGASGMLGTARL GQ+ GA++VA++L Sbjct: 404 MILCGAGFGLFQSPNNHTIITSAPRERSGGASGMLGTARLLGQSSGAALVALML 457 >ECs2538 [GEPR] COG0477 Permeases of the major facilitator superfamily Ecs Escherichia coli O157:H7 Length = 494 Score = 384 bits (987), Expect = e-106, Method: Compositional matrix adjust. Identities = 210/414 (50%), Positives = 282/414 (68%), Gaps = 3/414 (0%) Query: 15 DGLPPRQRLLAIATVVLGLSIAVLDGSIANLALPLMAADLKASDADAIWVINSYQIAMAV 74 DGLP QR AI T+V+G+S+AVLDG+IAN+ALP +A DL A+ A +IWV+N+YQIA+ + Sbjct: 44 DGLPLPQRYGAILTIVIGISMAVLDGAIANVALPTIATDLHATPASSIWVVNAYQIAIVI 103 Query: 75 CLLPLASLGEVIGYRRVYLGGVFLFTLASLACAASGDMLQLSLARVLQGLGAAGILSVNT 134 LL + LG++ GYRR+Y G+ +F L+SL CA S + L+LARV+QG G A ++SVNT Sbjct: 104 SLLSFSFLGDMFGYRRIYKCGLVVFLLSSLFCALSDSLQILTLARVIQGFGGAALMSVNT 163 Query: 135 ALIRFIYPSRLLGRAIGYNALVAGTGNALGPTVAGLILHLATWHWLFLINIPLGLAALAV 194 ALIR IYP R LGR +G N+ + +A GPT+A IL +A+W WLFLIN+PLG+ AL + Sbjct: 164 ALIRLIYPQRFLGRGMGINSFIVAVSSAAGPTIAAAILSIASWKWLFLINVPLGIIALLL 223 Query: 195 GHRALPTN-PLSARP-FDRQSALLCMCFIGLLLYTIDAVGHLQGAWVVGGCTVLTAISLV 252 R LP N +++P FD SA++ GLL+ + Q ++ V+ + + Sbjct: 224 AMRFLPPNGSRASKPRFDLPSAVMNALTFGLLITALSGFAQGQSLTLIAAELVVMVVVGI 283 Query: 253 LLLRLQ-SSSAPMLPLDLLRIPLFALSIGTSFCSFAAQMAVFVMLPFMLQNQQGMSVARA 311 +R Q S P+LP+DLLRIPLF+LSI TS CSF AQM V LPF LQ G S Sbjct: 284 FFIRRQLSLPVPLLPVDLLRIPLFSLSICTSVCSFCAQMLAMVSLPFYLQTVLGRSEVET 343 Query: 312 GLLLTAWPIAVALTGVMAGKLSDRIAAGLLGGIGLAVMCLGLLSLLLVQPGTPDGVMVAM 371 GLLLT WP+A + +AG L +R+ AGLLG +GL +M GL SL+L+ D ++ Sbjct: 344 GLLLTPWPLATMVMAPLAGYLIERVHAGLLGALGLFIMAAGLFSLVLLPASPADINIIWP 403 Query: 372 FALCGVGFGLFQTPNNRTMISAAPRERTGGASGMLGTARLTGQTVGASVVAMLL 425 LCG GFGLFQ+PNN T+I++APRER+GGASGMLGTARL GQ+ GA++VA++L Sbjct: 404 MILCGAGFGLFQSPNNHTIITSAPRERSGGASGMLGTARLLGQSSGAALVALML 457 >STM1843 [GEPR] COG0477 Permeases of the major facilitator superfamily Sty Salmonella typhimurium LT2 Length = 457 Score = 381 bits (978), Expect = e-105, Method: Compositional matrix adjust. Identities = 207/418 (49%), Positives = 281/418 (67%), Gaps = 3/418 (0%) Query: 11 HTNHDGLPPRQRLLAIATVVLGLSIAVLDGSIANLALPLMAADLKASDADAIWVINSYQI 70 T DGLP QR AI T+++G+S+AVLDG+IAN+ALP +A DL AS A +IW++N+YQI Sbjct: 3 KTRADGLPLPQRYGAILTIIIGISMAVLDGAIANVALPTIATDLHASPASSIWIVNAYQI 62 Query: 71 AMAVCLLPLASLGEVIGYRRVYLGGVFLFTLASLACAASGDMLQLSLARVLQGLGAAGIL 130 A+ V LL L+ LG++ GY R+Y G+ +F L+SL CA S + L+LAR+ QG G A ++ Sbjct: 63 AIVVSLLSLSFLGDMFGYHRIYKCGLVVFLLSSLFCALSDSLQMLTLARIAQGFGGAALM 122 Query: 131 SVNTALIRFIYPSRLLGRAIGYNALVAGTGNALGPTVAGLILHLATWHWLFLINIPLGLA 190 SVNTALIR IYP R LGR +G N+ + +A GPT+A IL +++W WLFLIN+PLG+ Sbjct: 123 SVNTALIRLIYPQRHLGRGMGINSFIVAVSSAAGPTIAAAILSISSWKWLFLINVPLGII 182 Query: 191 ALAVGHRALPTN-PLSARP-FDRQSALLCMCFIGLLLYTIDAVGHLQGAWVVGGCTVLTA 248 AL + R LP N +P FD SA++ GLL+ + Q ++G ++ Sbjct: 183 ALILAIRFLPANIAHDTKPRFDLPSAVMNALTFGLLITALSGFAQGQSLTLIGAELLVLV 242 Query: 249 ISLVLLLRLQ-SSSAPMLPLDLLRIPLFALSIGTSFCSFAAQMAVFVMLPFMLQNQQGMS 307 + +R Q S P+LP+DLLRIPLF+LSIGTS CSF AQM V LPF LQ G S Sbjct: 243 VVGFFFVRRQLSLPVPLLPIDLLRIPLFSLSIGTSICSFCAQMLAMVSLPFYLQTVLGRS 302 Query: 308 VARAGLLLTAWPIAVALTGVMAGKLSDRIAAGLLGGIGLAVMCLGLLSLLLVQPGTPDGV 367 GLLLT WP+A + +AG L +R+ AGLLG +G+ +M GL +L+++ D Sbjct: 303 EVETGLLLTPWPLATMVMAPLAGYLIERLHAGLLGALGMVIMAAGLFALVMLPASPSDLN 362 Query: 368 MVAMFALCGVGFGLFQTPNNRTMISAAPRERTGGASGMLGTARLTGQTVGASVVAMLL 425 ++ LCG GFGLFQ+PNN T+I++APRER+GGASGMLGTARL GQ+ GA++VA++L Sbjct: 363 IIWPMILCGAGFGLFQSPNNHTIITSAPRERSGGASGMLGTARLLGQSTGAALVALML 420