BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.1504.p (391 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc1031 [H] COG1488 Nicotinic acid phosphoribosyltransferase Rso... 610 e-174 XF1097 [H] COG1488 Nicotinic acid phosphoribosyltransferase Xfa ... 548 e-156 NMA1706 [H] COG1488 Nicotinic acid phosphoribosyltransferase NmA... 419 e-117 NMB1505 [H] COG1488 Nicotinic acid phosphoribosyltransferase Nme... 414 e-115 PA4919 [H] COG1488 Nicotinic acid phosphoribosyltransferase Pae ... 394 e-109 >RSc1031 [H] COG1488 Nicotinic acid phosphoribosyltransferase Rso Ralstonia solanacearum Length = 404 Score = 610 bits (1574), Expect = e-174, Method: Compositional matrix adjust. Identities = 282/390 (72%), Positives = 325/390 (83%), Gaps = 1/390 (0%) Query: 1 MIITSLLDTDLYKFTMMQVVLHHFPGAQVEYRFKCRNENIDLTPYVDEIRAEIAALCRLR 60 MII SLLDTDLYKFTMMQVVLHHFPGA VEYRFKCRN +DL PY++ IRAEI LC LR Sbjct: 16 MIIRSLLDTDLYKFTMMQVVLHHFPGAHVEYRFKCRNPGVDLVPYIEAIRAEIRHLCSLR 75 Query: 61 FKEDELNYLRSLRFIKSDFVDFLDLFHLNEKYITVQPDPAGNGEIEISVKGPWLHTIMFE 120 F E EL+YLR LRFIKSDFVDFLDLFHL+EKYI ++P + +G+I+I + GPWLHTIMFE Sbjct: 76 FTEAELDYLRGLRFIKSDFVDFLDLFHLSEKYIDIRPAASNDGQIDIVISGPWLHTIMFE 135 Query: 121 VPVLAIVNEVYFRATQRSPDLEEGRARLRKKMSVITDDPELAGCKIADYGTRRRFSRSWH 180 VPVLAIVNEVYF TQ P +EG+ RL +K++ +T P L C+IADYGTRRRFS +WH Sbjct: 136 VPVLAIVNEVYFSRTQAHPQWDEGKRRLTEKLASLTR-PGLEDCRIADYGTRRRFSHTWH 194 Query: 181 AEVIDEMKQHMGSHFAGTSNVMYAMQHDLTPLGTMAHEYLQACQALGPRLRDSQTFAFEM 240 V+ E + +GS +AGTSNV +AM+H++TPLGTMAHEYLQACQ+LGPRLRDSQ FA E Sbjct: 195 EHVLMEARSQLGSQYAGTSNVYFAMKHNMTPLGTMAHEYLQACQSLGPRLRDSQVFALET 254 Query: 241 WAREYRGDLGITLSDVYGMDAFLRDYDMYFCKLFDGARHDSGDPFEWGERLIQHYRDNRV 300 WAREYRGDLGI LSD YG DAFLRD+DM+FCKLFDG RHDSGDPFEWGER+++HY RV Sbjct: 255 WAREYRGDLGIALSDTYGFDAFLRDFDMFFCKLFDGVRHDSGDPFEWGERMLKHYEGMRV 314 Query: 301 DPSSKVLVFSDSLDFDKVRALYLRFKDRAKVAFGVGTNLTNDLGYTPLQVVMKMVRCNGQ 360 DP SK L+FSDSLD KV LY RF+ R K+AFGVGTNLTNDLGYTPLQ+V+KMVRCNGQ Sbjct: 315 DPQSKALIFSDSLDMPKVVRLYERFRSRCKLAFGVGTNLTNDLGYTPLQIVIKMVRCNGQ 374 Query: 361 PVAKLSDTPSKNMCDDPAYVNYLRQVFQIK 390 PVAKLSD P K MCDDPAY+ YL+QVF ++ Sbjct: 375 PVAKLSDAPEKTMCDDPAYLAYLKQVFGVQ 404 >XF1097 [H] COG1488 Nicotinic acid phosphoribosyltransferase Xfa Xylella fastidiosa 9a5c Length = 394 Score = 548 bits (1413), Expect = e-156, Method: Compositional matrix adjust. Identities = 256/390 (65%), Positives = 311/390 (79%), Gaps = 1/390 (0%) Query: 2 IITSLLDTDLYKFTMMQVVLHHFPGAQVEYRFKCRNENIDLTPYVDEIRAEIAALCRLRF 61 II SLLDTDLYKFTMMQ VLH +PGAQVEYRFKCR +DL +++EI EI LC LRF Sbjct: 4 IIKSLLDTDLYKFTMMQAVLHQYPGAQVEYRFKCRTPGVDLARFINEISHEIDGLCALRF 63 Query: 62 KEDELNYLRSLRFIKSDFVDFLDLFHLNEKYITVQPDPAGNGEIEISVKGPWLHTIMFEV 121 ++EL+YLR LRF+K DFVDFL LFHL+ KY+ ++ +GEIE+ ++GPWLHTI+FEV Sbjct: 64 SKEELDYLRGLRFMKPDFVDFLGLFHLDRKYLQLRASTQVSGEIELDIRGPWLHTILFEV 123 Query: 122 PVLAIVNEVYFRATQRSPDLEEGRARLRKKMSVITDDPELAGCKIADYGTRRRFSRSWHA 181 P+LAI+NEV+FR T +L+ GRARL K+ ++ + C IADYGTRRR+SR WHA Sbjct: 124 PLLAIINEVWFRNTSML-NLDVGRARLDAKVRLLKGESGYEECSIADYGTRRRYSRQWHA 182 Query: 182 EVIDEMKQHMGSHFAGTSNVMYAMQHDLTPLGTMAHEYLQACQALGPRLRDSQTFAFEMW 241 E++ + Q +GS+F GTSNV +A Q+ TPLGTMAHEYLQA QALGPRLRDSQ E W Sbjct: 183 ELLPLLAQGLGSNFVGTSNVYFAKQYGYTPLGTMAHEYLQAFQALGPRLRDSQVAGLEAW 242 Query: 242 AREYRGDLGITLSDVYGMDAFLRDYDMYFCKLFDGARHDSGDPFEWGERLIQHYRDNRVD 301 AREYRGDLGI LSDV G+DAFL D+D+YFCKLFDG RHDSGDPF+WGER+I H +R+D Sbjct: 243 AREYRGDLGIALSDVVGLDAFLGDFDLYFCKLFDGMRHDSGDPFKWGERIIMHLESHRID 302 Query: 302 PSSKVLVFSDSLDFDKVRALYLRFKDRAKVAFGVGTNLTNDLGYTPLQVVMKMVRCNGQP 361 P +KVLVFSD LD +KV LY F+ R ++AFGVGT+LTNDLG TPLQ+V+KMVRCNGQP Sbjct: 303 PRTKVLVFSDGLDMNKVMRLYQHFRGRCRLAFGVGTSLTNDLGPTPLQIVIKMVRCNGQP 362 Query: 362 VAKLSDTPSKNMCDDPAYVNYLRQVFQIKA 391 VAKLSD+P K+MCDDPAY++YLRQVF + A Sbjct: 363 VAKLSDSPGKSMCDDPAYLHYLRQVFGVSA 392 >NMA1706 [H] COG1488 Nicotinic acid phosphoribosyltransferase NmA Neisseria meningitidis Z2491 Length = 419 Score = 419 bits (1076), Expect = e-117, Method: Compositional matrix adjust. Identities = 204/395 (51%), Positives = 272/395 (68%), Gaps = 9/395 (2%) Query: 2 IITSLLDTDLYKFTMMQVVLHHFPGAQVEYRFKCRNENI--DLTPYVDEIRAEIAALCRL 59 II SLLDTDLYKFTM+QVVLH FP Y F+CRN + L +++ E+ ALC+L Sbjct: 21 IIHSLLDTDLYKFTMLQVVLHQFPQTHSLYEFRCRNASTVYPLADIKEDLEVELDALCQL 80 Query: 60 RFKEDELNYLRSLRFIKSDFVDFLDLFHLNEKYITVQPDPAGNGEIEISVKGPWLHTIMF 119 RF DEL+YLRSLRFIKSDFVD+L+LF L +++ V D G + I ++GP + + F Sbjct: 81 RFTHDELDYLRSLRFIKSDFVDYLELFQLQRRFVEVGTD--DKGRLNIRIEGPMIQAMFF 138 Query: 120 EVPVLAIVNEVYFRATQRSPDLEEGRARLRKKMSVITD-----DPELAGCKIADYGTRRR 174 E+ +LAIVNE+YFR + +EEG RL+ K + + + +P+ I+D+GTRRR Sbjct: 139 EIFILAIVNELYFRRLETPAVIEEGERRLQAKAARLKEIAAAQNPDEPPFLISDFGTRRR 198 Query: 175 FSRSWHAEVIDEMKQHMGSHFAGTSNVMYAMQHDLTPLGTMAHEYLQACQALGPRLRDSQ 234 + +W VI + + S GTSNV A + +TP+GTMAHE+LQA QAL RLR+ Q Sbjct: 199 YKLAWQEHVIRTLLEAAPSIVRGTSNVFLAKKLGITPIGTMAHEFLQAFQALDVRLRNFQ 258 Query: 235 TFAFEMWAREYRGDLGITLSDVYGMDAFLRDYDMYFCKLFDGARHDSGDPFEWGERLIQH 294 A E W EYRGDLG+ L+DV GMDAFLRD+D+YF KLFDG RHDSGDP+ WG++ H Sbjct: 259 KAALESWVHEYRGDLGVALTDVVGMDAFLRDFDLYFAKLFDGLRHDSGDPYIWGDKAYAH 318 Query: 295 YRDNRVDPSSKVLVFSDSLDFDKVRALYLRFKDRAKVAFGVGTNLTNDLGYTPLQVVMKM 354 Y+ ++D +K+L FSD LD ++ AL+ FKDR K FG+GTNLTND+G+TPL +V+K+ Sbjct: 319 YQKLKIDSRTKMLTFSDGLDIERSWALHQYFKDRFKTGFGIGTNLTNDMGHTPLNIVLKL 378 Query: 355 VRCNGQPVAKLSDTPSKNMCDDPAYVNYLRQVFQI 389 V CNGQ VAKLSD+P K M ++ ++ YLRQVF + Sbjct: 379 VECNGQSVAKLSDSPGKTMTNNSTFLAYLRQVFDV 413 >NMB1505 [H] COG1488 Nicotinic acid phosphoribosyltransferase Nme Neisseria meningitidis MC58 Length = 402 Score = 414 bits (1065), Expect = e-115, Method: Compositional matrix adjust. Identities = 203/396 (51%), Positives = 271/396 (68%), Gaps = 11/396 (2%) Query: 2 IITSLLDTDLYKFTMMQVVLHHFPGAQVEYRFKCRNENIDLTPYVD---EIRAEIAALCR 58 II SLLDTDLYKFTM+QVVLH FP Y F+CRN + + P D ++ AE+ ALC+ Sbjct: 4 IIHSLLDTDLYKFTMLQVVLHQFPQTHSLYEFRCRNAST-VYPLADIREDLEAELDALCQ 62 Query: 59 LRFKEDELNYLRSLRFIKSDFVDFLDLFHLNEKYITVQPDPAGNGEIEISVKGPWLHTIM 118 LRF DEL YLRSLRFIKSDFVD+L+LF L +++ + D + I ++GP + + Sbjct: 63 LRFTHDELGYLRSLRFIKSDFVDYLELFQLQRRFVEIGTD--DKDRLNIRIEGPMIQAMF 120 Query: 119 FEVPVLAIVNEVYFRATQRSPDLEEGRARLRKKMSVITD-----DPELAGCKIADYGTRR 173 FE+ +LAIVNE+YFR + +EEG RL+ K + + + +P+ I+D+GTRR Sbjct: 121 FEIFILAIVNELYFRRLETPAVIEEGERRLQAKAARLKEIAAAQNPDEPPFLISDFGTRR 180 Query: 174 RFSRSWHAEVIDEMKQHMGSHFAGTSNVMYAMQHDLTPLGTMAHEYLQACQALGPRLRDS 233 R+ +W VI + + GTSNV A + +TP+GTMAHE+LQA QAL RLR+ Sbjct: 181 RYKLAWQEHVIRTLLEAAPGIVRGTSNVFLAKKLGITPIGTMAHEFLQAFQALDVRLRNF 240 Query: 234 QTFAFEMWAREYRGDLGITLSDVYGMDAFLRDYDMYFCKLFDGARHDSGDPFEWGERLIQ 293 Q A E W EYRGDLG+ L+DV GMDAFLRD+D+YF KLFDG RHDSGDP+ WG++ Sbjct: 241 QKAALESWVHEYRGDLGVALTDVVGMDAFLRDFDLYFAKLFDGLRHDSGDPYVWGDKAYA 300 Query: 294 HYRDNRVDPSSKVLVFSDSLDFDKVRALYLRFKDRAKVAFGVGTNLTNDLGYTPLQVVMK 353 HY+ ++D +K+L FSD LD ++ AL+ FKDR K FG+GTNLTND+G+TPL +V+K Sbjct: 301 HYQKLKIDSRTKMLTFSDGLDIERSWALHQYFKDRFKTGFGIGTNLTNDMGHTPLNIVLK 360 Query: 354 MVRCNGQPVAKLSDTPSKNMCDDPAYVNYLRQVFQI 389 +V CNGQ VAKLSD+P K M ++ ++ YLRQVF + Sbjct: 361 LVECNGQSVAKLSDSPGKTMTNNSTFLAYLRQVFDV 396 >PA4919 [H] COG1488 Nicotinic acid phosphoribosyltransferase Pae Pseudomonas aeruginosa Length = 399 Score = 394 bits (1011), Expect = e-109, Method: Compositional matrix adjust. Identities = 198/394 (50%), Positives = 256/394 (64%), Gaps = 8/394 (2%) Query: 2 IITSLLDTDLYKFTMMQVVLHHFPGAQVEYRFKCRNENIDLTPYVDEIRAEIAALCRLRF 61 I+ +LLDTD YK TMMQ VLH++P A+VE+ F+CRN DL PY+ EIR +I L + Sbjct: 10 IVQNLLDTDFYKLTMMQAVLHNYPNAEVEWEFRCRNAE-DLRPYLAEIRYQIERLAEVEV 68 Query: 62 KEDELNYLRSLRFIKSDFVDFLDLFHLNEKYITVQPDPAGNGEIEISVKGPWLHTIMFEV 121 D+L +L + F+K DF+ FL LF N +Y+ + +G++ I ++GPWLH I+FEV Sbjct: 69 TADQLAFLERIPFMKPDFIRFLSLFRFNLRYVHTGIE---DGQLAIRLRGPWLHVILFEV 125 Query: 122 PVLAIVNEVYFRATQRSPDLEEGRARLRKKM---SVITDDPELAGCKIADYGTRRRFSRS 178 P+LAIV+EV R R LE+ +L +K+ S ELA ++AD+GTRRRFS Sbjct: 126 PLLAIVSEVRNRYRYREVVLEQVGEQLYRKLDWLSAQASSEELAEFQVADFGTRRRFSYR 185 Query: 179 WHAEVIDEMKQHMGSHFAGTSNVMYAMQHDLTPLGTMAHEYLQACQALGPRLRDSQTFAF 238 EV+ +K+ F GTSNV A ++DL P+GTMAHE+L A Q LGPRL DSQ A Sbjct: 186 TQEEVVHILKRDFPGRFVGTSNVHLAREYDLKPIGTMAHEWLMAHQQLGPRLVDSQQAAL 245 Query: 239 EMWAREYRGDLGITLSDVYGMDAFLRDYDMYFCKLFDGARHDSGDPFEWGERLIQHYRDN 298 + W REYRG LGI L+D MDAFL D+D+YF KLFDG RHDSGDP W E+ I HYR Sbjct: 246 DCWVREYRGQLGIALTDCITMDAFLDDFDLYFAKLFDGLRHDSGDPLAWAEKAIAHYRRL 305 Query: 299 RVDPSSKVLVFSDSLDFDKVRALYLRFKDRAKVAFGVGTNLTNDL-GYTPLQVVMKMVRC 357 +DP SK LVFSD LD K L+ + + V+FG+GTNLT D+ G P+ +V+KM C Sbjct: 306 GIDPLSKTLVFSDGLDMPKALQLFRALRGKINVSFGIGTNLTCDIPGVEPMNIVLKMTAC 365 Query: 358 NGQPVAKLSDTPSKNMCDDPAYVNYLRQVFQIKA 391 NG PVAK+SD P K C D +V YLR VF + A Sbjct: 366 NGHPVAKISDAPGKTQCRDENFVAYLRHVFNVPA 399