BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.1167.p (408 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value lin2949 [GEPR] COG0477 Permeases of the major facilitator superf... 206 7e-53 RSp1614 [GEPR] COG0477 Permeases of the major facilitator superf... 161 2e-39 yhaU [GEPR] COG0477 Permeases of the major facilitator superfami... 152 2e-36 ZyhaU [GEPR] COG0477 Permeases of the major facilitator superfam... 152 2e-36 ECs4005 [GEPR] COG0477 Permeases of the major facilitator superf... 152 2e-36 >lin2949 [GEPR] COG0477 Permeases of the major facilitator superfamily Lin Listeria innocua Length = 401 Score = 206 bits (524), Expect = 7e-53, Method: Compositional matrix adjust. Identities = 130/403 (32%), Positives = 220/403 (54%), Gaps = 5/403 (1%) Query: 5 ITKSKGEGKYKYLVLVLLYLGWCVSYIDRAAITFAATQIASEFHLNPSDLGLLLSSFFLG 64 + + KGE K+ +VL++L++G+ Y+D+ I + ++ + +PS GL+LS+FFLG Sbjct: 1 MNQVKGE-KHSLMVLLVLFIGYTSVYVDKYTIGISLVTVSQDLGFDPSQKGLILSAFFLG 59 Query: 65 YSLLQLPGGWLADRYGSRPVIVVSILMWSIFTGVTGMAWSVTSLVVIRFVFGV-GEGAFP 123 Y+L Q+P G+L +R G+RPV+ +SI++ +F + G +S+ LVVIRF+ G G +P Sbjct: 60 YTLFQIPMGYLNNRIGARPVLAISIIIVGLFLIIFGFGYSLLFLVVIRFLSGAFGHAGYP 119 Query: 124 AASIKGVAENFAREERPKISSLLISSNYIGSMLAPLLIAPLILHFGWRNVFHTIGIAGLV 183 + ++ + +R S +++S+ + + PLLIA L+L GWRN ++ IGI ++ Sbjct: 120 PSVSNYISLHIPLNKRGFAQSAMLASSGFAAFIGPLLIAQLLLSVGWRNTYYWIGIV-VI 178 Query: 184 FALVYWFCVRPVKPGLDG--PKAINKAAFAALLKMPLMWKIVAVWFGLSIINKGLDSWMP 241 F + V P P +D K K F+ LLK +W ++ ++ N GL SW+ Sbjct: 179 FIGLLILLVVPKAPKIDKSTQKEKIKVPFSELLKDKQLWILLLSALFINAANYGLTSWLA 238 Query: 242 TYLMTVRGLNLKTVGLLLPLPYIMAGLSTAIGGWVMVRFFDGREKLLLIASSLLTAVFVY 301 +YL RG+++ V + L + ++ IGG+ + RFF G+E +++ S+L A VY Sbjct: 239 SYLNEARGISISEVSYISSLAGLCILIAGVIGGYFISRFFKGKEPIVIFTFSVLGAFTVY 298 Query: 302 CMYTASSVEGVIAWQCLAYFFKSFVLATCIALPTKLLQAQLVGSGVGMVNLGGQLAGFIS 361 +Y + I CL F T + LP KL + + + +N GG L GF + Sbjct: 299 GVYLFDQLMLSIICLCLCNIFLIMAFTTLMGLPHKLFKQSHIATKYAAINSGGVLGGFFA 358 Query: 362 PLVIGFLVSAFANYDYAFGFLISAALFSVVVSLFIRTSKTSAQ 404 P++IG LV+A +Y AF FL L S ++ L I+ ++ Sbjct: 359 PMIIGDLVNATNSYQSAFLFLALTFLVSGIIVLAIKKRSVISE 401 >RSp1614 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 448 Score = 161 bits (408), Expect = 2e-39, Method: Compositional matrix adjust. Identities = 129/417 (30%), Positives = 207/417 (49%), Gaps = 38/417 (9%) Query: 6 TKSKGE-GKYKYLVLVLLYLGWCVSYIDRAAITFAATQIASEFHLNPSDLGLLLSSFFLG 64 T +G+ K ++LV L++ ++YIDR ++ AA I EFHL+ ++G+++S+FF Sbjct: 4 TPQRGQRSKVRWLVAGLMWAAIAINYIDRTVLSAAAPHIQKEFHLSAVEMGVVMSAFFWS 63 Query: 65 YSLLQLPGGWLADRYGSRPVIVVSILMWSIFTGVTGMAWSVTSLVVIRFVFGVGE-GAFP 123 Y+LLQLP G LADR+G + V+ ++L WS+ T VTG+A SLV +R GVGE GA+P Sbjct: 64 YALLQLPAGILADRFGQKKVLGFAVLWWSLATAVTGLATGFKSLVGLRVALGVGEAGAYP 123 Query: 124 AASIKGVAEN-FAREERPKISSLLISSNYIGSMLAPLLIAPLILHFGWRNVFHTIGIAGL 182 S G+ F ++ER ++++ S + +GS +A LIA L++ F W+ F G G+ Sbjct: 124 --SNAGITSRWFPKQERATVAAIFDSGSKLGSAIALPLIAWLLVTFDWKITFTVAGSLGI 181 Query: 183 VFALVYWFCVRPVKPGLDGPKAINKAAFAALLK---------MPLM-W-------KIVAV 225 V+ +V+ R +G +N A A + K P M W + A+ Sbjct: 182 VWCVVWALVFRDSPAEHEG---VNAAELAHIQKGLPPARGADAPAMPWTKLLTHRNVWAM 238 Query: 226 WFGLSIINKG---LDSWMPTYLMTVRGLNLKTVGLLLPLPYIMAGLSTAIGGWVMVRFF- 281 G +IN +W+PTYL+ RG+ L +G + LP ++ GW R + Sbjct: 239 CIGFFMINYNSYFFITWLPTYLVKERGMGLMEMGFMASLPLFVSMFVEVFAGWASDRVYA 298 Query: 282 DGR------EKLLLIASSLLTAVFVYCMYTASSVEGVIAWQCLAYFFKSFVLATCIALPT 335 GR KL L+ ++ + + S+V VI C+A + + ALP Sbjct: 299 SGRLSLTATRKLFLVIGLVMASSIGLAAFAQSAVVAVIL-LCIAKSGTTVAASQVWALPA 357 Query: 336 KLLQAQLVGSGVGMVNLGGQLAGFISPLVIGFLVSAFANYDYAFGFLISAALFSVVV 392 + V G+ N + G + P+V G +V A ++ A F SAAL + + Sbjct: 358 DVAPGNTVSMVAGLQNSVSNMGGVVGPIVTGAIVGATGSFIPALVF--SAALIGLAI 412 >yhaU [GEPR] COG0477 Permeases of the major facilitator superfamily Eco Escherichia coli K12 Length = 444 Score = 152 bits (384), Expect = 2e-36, Method: Compositional matrix adjust. Identities = 124/450 (27%), Positives = 217/450 (48%), Gaps = 53/450 (11%) Query: 1 MEAAITKSKGEGKYKYLVLVLLYLGWCVSYIDRAAITFAATQIASEFHLNPSDLGLLLSS 60 ++ K KG +YL+L+++++ V+Y DRA ++ A T++A E L+ +G + S+ Sbjct: 3 LDTVDEKKKGV-HTRYLILLIIFIVTAVNYADRATLSIAGTEVAKELQLSAVSMGYIFSA 61 Query: 61 FFLGYSLLQLPGGWLADRYGSRPVIVVSILMWSIFTGVTG------MAWSVTSLVVIRFV 114 F Y L+Q+PGGWL D++GS+ V S+ WS+FT + G +AW+ S+ +RF+ Sbjct: 62 FGWAYLLMQIPGGWLLDKFGSKKVYTYSLFFWSLFTFLQGFVDMFPLAWAGISMFFMRFM 121 Query: 115 FGVGEGAFPAASIKGVAENFAREERPKISSLLISSNYIGSMLAPLLIAPLILHFGWRNVF 174 G E A+ + VA F +ER S++ S+ Y L L+ L +GW +VF Sbjct: 122 LGFSEAPSFPANARIVAAWFPTKERGTASAIFNSAQYFSLALFSPLLGWLTFAWGWEHVF 181 Query: 175 HTIGIAGLVFALVYWFCVRPVKPGLDGPK---------AINKAAFAALLKMP-------- 217 +G+ G V ++ ++ + D P+ + N A K P Sbjct: 182 TVMGVIGFVLTALW---IKLIHNPTDHPRMSAEELKFISENGAVVDMDHKKPGSAAASGP 238 Query: 218 -LMW--------KIVAVWFGLSIINK---GLDSWMPTYLMTVRGLNLKTVGLLLPLPYIM 265 L + ++ V+FG IN +W P YL+ +G+++ VGL+ +P + Sbjct: 239 KLHYIKQLLSNRMMLGVFFGQYFINTITWFFLTWFPIYLVQEKGMSILKVGLVASIP-AL 297 Query: 266 AGLSTAIGGWVMVRFFDGR-------EKLLLIASSLLTAVFVYCMYTASSVEGVIAWQCL 318 G + + G V + R KL ++ LL + + C YT ++ V+ L Sbjct: 298 CGFAGGVLGGVFSDYLIKRGLSLTLARKLPIVLGMLLASTIILCNYTNNTTL-VVMLMAL 356 Query: 319 AYFFKSFVLATCIALP--TKLLQAQLVGSGVGMVNLGGQLAGFISPLVIGFLVSAFANYD 376 A+F K F + P + ++VG G+ N+ G +A ++PLVIG+LVS +++ Sbjct: 357 AFFGKGF---GALGWPVISDTAPKEIVGLCGGVFNVFGNVASIVTPLVIGYLVSELHSFN 413 Query: 377 YAFGFLISAALFSVVVSLFIRTSKTSAQMQ 406 A F+ +AL ++V LF+ ++Q Sbjct: 414 AALVFVGCSALMAMVCYLFVVGDIKRMELQ 443 >ZyhaU [GEPR] COG0477 Permeases of the major facilitator superfamily EcZ Escherichia coli O157:H7 EDL933 Length = 444 Score = 152 bits (384), Expect = 2e-36, Method: Compositional matrix adjust. Identities = 124/450 (27%), Positives = 217/450 (48%), Gaps = 53/450 (11%) Query: 1 MEAAITKSKGEGKYKYLVLVLLYLGWCVSYIDRAAITFAATQIASEFHLNPSDLGLLLSS 60 ++ K KG +YL+L+++++ V+Y DRA ++ A T++A E L+ +G + S+ Sbjct: 3 LDTVDEKKKGV-HTRYLILLIIFIVTAVNYADRATLSIAGTEVAKELQLSAVSMGYIFSA 61 Query: 61 FFLGYSLLQLPGGWLADRYGSRPVIVVSILMWSIFTGVTG------MAWSVTSLVVIRFV 114 F Y L+Q+PGGWL D++GS+ V S+ WS+FT + G +AW+ S+ +RF+ Sbjct: 62 FGWAYLLMQIPGGWLLDKFGSKKVYTYSLFFWSLFTFLQGFVDMFPLAWAGISMFFMRFM 121 Query: 115 FGVGEGAFPAASIKGVAENFAREERPKISSLLISSNYIGSMLAPLLIAPLILHFGWRNVF 174 G E A+ + VA F +ER S++ S+ Y L L+ L +GW +VF Sbjct: 122 LGFSEAPSFPANARIVAAWFPTKERGTASAIFNSAQYFSLALFSPLLGWLTFAWGWEHVF 181 Query: 175 HTIGIAGLVFALVYWFCVRPVKPGLDGPK---------AINKAAFAALLKMP-------- 217 +G+ G V ++ ++ + D P+ + N A K P Sbjct: 182 TVMGVIGFVLTALW---IKLIHNPTDHPRMSAEELKFISENGAVVDMDHKKPGSAAASGP 238 Query: 218 -LMW--------KIVAVWFGLSIINK---GLDSWMPTYLMTVRGLNLKTVGLLLPLPYIM 265 L + ++ V+FG IN +W P YL+ +G+++ VGL+ +P + Sbjct: 239 KLHYIKQLLSNRMMLGVFFGQYFINTITWFFLTWFPIYLVQEKGMSILKVGLVASIP-AL 297 Query: 266 AGLSTAIGGWVMVRFFDGR-------EKLLLIASSLLTAVFVYCMYTASSVEGVIAWQCL 318 G + + G V + R KL ++ LL + + C YT ++ V+ L Sbjct: 298 CGFAGGVLGGVFSDYLIKRGLSLTLARKLPIVLGMLLASTIILCNYTNNTTL-VVMLMAL 356 Query: 319 AYFFKSFVLATCIALP--TKLLQAQLVGSGVGMVNLGGQLAGFISPLVIGFLVSAFANYD 376 A+F K F + P + ++VG G+ N+ G +A ++PLVIG+LVS +++ Sbjct: 357 AFFGKGF---GALGWPVISDTAPKEIVGLCGGVFNVFGNVASIVTPLVIGYLVSELHSFN 413 Query: 377 YAFGFLISAALFSVVVSLFIRTSKTSAQMQ 406 A F+ +AL ++V LF+ ++Q Sbjct: 414 AALVFVGCSALMAMVCYLFVVGDIKRMELQ 443 >ECs4005 [GEPR] COG0477 Permeases of the major facilitator superfamily Ecs Escherichia coli O157:H7 Length = 444 Score = 152 bits (384), Expect = 2e-36, Method: Compositional matrix adjust. Identities = 124/450 (27%), Positives = 217/450 (48%), Gaps = 53/450 (11%) Query: 1 MEAAITKSKGEGKYKYLVLVLLYLGWCVSYIDRAAITFAATQIASEFHLNPSDLGLLLSS 60 ++ K KG +YL+L+++++ V+Y DRA ++ A T++A E L+ +G + S+ Sbjct: 3 LDTVDEKKKGV-HTRYLILLIIFIVTAVNYADRATLSIAGTEVAKELQLSAVSMGYIFSA 61 Query: 61 FFLGYSLLQLPGGWLADRYGSRPVIVVSILMWSIFTGVTG------MAWSVTSLVVIRFV 114 F Y L+Q+PGGWL D++GS+ V S+ WS+FT + G +AW+ S+ +RF+ Sbjct: 62 FGWAYLLMQIPGGWLLDKFGSKKVYTYSLFFWSLFTFLQGFVDMFPLAWAGISMFFMRFM 121 Query: 115 FGVGEGAFPAASIKGVAENFAREERPKISSLLISSNYIGSMLAPLLIAPLILHFGWRNVF 174 G E A+ + VA F +ER S++ S+ Y L L+ L +GW +VF Sbjct: 122 LGFSEAPSFPANARIVAAWFPTKERGTASAIFNSAQYFSLALFSPLLGWLTFAWGWEHVF 181 Query: 175 HTIGIAGLVFALVYWFCVRPVKPGLDGPK---------AINKAAFAALLKMP-------- 217 +G+ G V ++ ++ + D P+ + N A K P Sbjct: 182 TVMGVIGFVLTALW---IKLIHNPTDHPRMSAEELKFISENGAVVDMDHKKPGSAAASGP 238 Query: 218 -LMW--------KIVAVWFGLSIINK---GLDSWMPTYLMTVRGLNLKTVGLLLPLPYIM 265 L + ++ V+FG IN +W P YL+ +G+++ VGL+ +P + Sbjct: 239 KLHYIKQLLSNRMMLGVFFGQYFINTITWFFLTWFPIYLVQEKGMSILKVGLVASIP-AL 297 Query: 266 AGLSTAIGGWVMVRFFDGR-------EKLLLIASSLLTAVFVYCMYTASSVEGVIAWQCL 318 G + + G V + R KL ++ LL + + C YT ++ V+ L Sbjct: 298 CGFAGGVLGGVFSDYLIKRGLSLTLARKLPIVLGMLLASTIILCNYTNNTTL-VVMLMAL 356 Query: 319 AYFFKSFVLATCIALP--TKLLQAQLVGSGVGMVNLGGQLAGFISPLVIGFLVSAFANYD 376 A+F K F + P + ++VG G+ N+ G +A ++PLVIG+LVS +++ Sbjct: 357 AFFGKGF---GALGWPVISDTAPKEIVGLCGGVFNVFGNVASIVTPLVIGYLVSELHSFN 413 Query: 377 YAFGFLISAALFSVVVSLFIRTSKTSAQMQ 406 A F+ +AL ++V LF+ ++Q Sbjct: 414 AALVFVGCSALMAMVCYLFVVGDIKRMELQ 443