BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.1164.p (1049 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSp0818 [V] COG0841 Cation/multidrug efflux pump Rso Ralstonia s... 1771 0.0 STM0475 [V] COG0841 Cation/multidrug efflux pump Sty Salmonella ... 1377 0.0 acrB [V] COG0841 Cation/multidrug efflux pump Eco Escherichia co... 1370 0.0 ZacrB [V] COG0841 Cation/multidrug efflux pump EcZ Escherichia c... 1369 0.0 ECs0515 [V] COG0841 Cation/multidrug efflux pump Ecs Escherichia... 1369 0.0 >RSp0818 [V] COG0841 Cation/multidrug efflux pump Rso Ralstonia solanacearum Length = 1053 Score = 1771 bits (4588), Expect = 0.0, Method: Compositional matrix adjust. Identities = 869/1031 (84%), Positives = 954/1031 (92%) Query: 1 MARFFIDRPIFAWVLAIIVMLAGAISVLTLPIAQYPAIAPPAIAITANYPGASAKTLEDT 60 MAR+FIDRPIFAWVLAIIVMLAGA+S+ TLPIAQYP+IAPPA+AITA YPGASAKTLEDT Sbjct: 1 MARYFIDRPIFAWVLAIIVMLAGALSIATLPIAQYPSIAPPAVAITATYPGASAKTLEDT 60 Query: 61 VTQVIEQKMKGLDRLSYMASTSESSGTVTITLTFENGTNPDTAQVQVQNKLSLATPLLPT 120 VTQ+IEQKMKGLD LSYMASTSESSGTVTITLTF+NGT+PDTAQVQVQNKL+LATPLLP Sbjct: 61 VTQIIEQKMKGLDHLSYMASTSESSGTVTITLTFDNGTDPDTAQVQVQNKLALATPLLPQ 120 Query: 121 EVQQQGITVTKSATNFLNVLAFTSEDGSMSGSDLSDYVAANVQDAISRVQGVGDTTLFGS 180 EVQQQG+ VTKSATNFLNVLAFTSEDGSM+GSDLSDYVAANVQDA+SRV+GVGDTTLFGS Sbjct: 121 EVQQQGVQVTKSATNFLNVLAFTSEDGSMNGSDLSDYVAANVQDALSRVEGVGDTTLFGS 180 Query: 181 QYAMRIWLDPNKLNSYALTPLDVKNAIQAQNVQVSSGQLGGLPAVENQQINATITAQTRL 240 QYAMRIWLDP+KL++++LTPLDVK AIQAQN QVS+GQLGG+PA +NQQINATIT+QTRL Sbjct: 181 QYAMRIWLDPHKLSNFSLTPLDVKTAIQAQNAQVSAGQLGGMPAADNQQINATITSQTRL 240 Query: 241 RTADQFRNIVLRTLTGGAQVKLRDVARIELGSESYTSVGRYNGKPAAGLAIKLATGANAL 300 +TA+ F NI+LRT GAQV+LRDVARIELGSESY++VGRYNGKPAAGLAIKLATGANAL Sbjct: 241 KTAEAFGNILLRTQADGAQVRLRDVARIELGSESYSTVGRYNGKPAAGLAIKLATGANAL 300 Query: 301 DTVKAIDARVAQLEKFFPAGMKVQKPYDTTPFVRISIEEVVRTLVEAVVLVFLVMYLFLQ 360 DTVKAIDARVA+LE FFP GMKVQKPYDTTPFVRISIEEVVRTLVEA+ LVFLVMYLFLQ Sbjct: 301 DTVKAIDARVAELEPFFPPGMKVQKPYDTTPFVRISIEEVVRTLVEAIALVFLVMYLFLQ 360 Query: 361 NFRATLIPTIAVPVVLLGTFGVLAAFGFTINTLTMFAMVLAIGLLVDDAIVVVENVERVM 420 NFRATLIPTIAVPVVLLGTFGVLAA GFTINTLTMFAMVLAIGLLVDDAIVVVENVERVM Sbjct: 361 NFRATLIPTIAVPVVLLGTFGVLAACGFTINTLTMFAMVLAIGLLVDDAIVVVENVERVM 420 Query: 421 SEDGLPPKEATRKSMGQITGALVGVALVLAAVFVPMAFFSGSTGVIYRQFSITIVSAMTL 480 SE+GLPP+EATRKSMGQITGAL+GVALVLAAVFVPMAFF GSTGVIYRQFSITIVSAMTL Sbjct: 421 SEEGLPPREATRKSMGQITGALIGVALVLAAVFVPMAFFKGSTGVIYRQFSITIVSAMTL 480 Query: 481 SVLVAIVLTPALCATLLKPAAKGHALATSGFFGWFNRQFDRGNRRYQGVVRHMLGRGWRY 540 SVLVA+VLTPALCATLLKP KGHA AT+GFFGWFNR FDRGN RYQG+VRHMLG+ RY Sbjct: 481 SVLVAMVLTPALCATLLKPVRKGHAQATTGFFGWFNRTFDRGNHRYQGIVRHMLGKQRRY 540 Query: 541 MAAYAVLLALVVTGFMKLPVGFLPDEDQGSLFAIMQLPAGATKARTDDVIHQVEHHFLVD 600 MA Y VL A+VV GFMKLPVGFLPDEDQG+LF + QLP GAT ART+DV+ QVEHHFLVD Sbjct: 541 MAMYGVLFAMVVVGFMKLPVGFLPDEDQGTLFVLAQLPPGATNARTEDVLRQVEHHFLVD 600 Query: 601 QKDAVAGVFSVSGFSFAGSGQNMGFAFIKLKPWDERKGPGLSVTDVVNKAGAAFAKIRDA 660 QK+AV+GVFSV+GFSFAGSGQNMGFAF+KL+PW+ERKG LSV+ VV +A FA IRDA Sbjct: 601 QKEAVSGVFSVAGFSFAGSGQNMGFAFVKLRPWNERKGEALSVSGVVARAFGFFATIRDA 660 Query: 661 KVFAFAPPAVAELGNATGFDLMLKDEANLGHAALMQARNQLLATLTKDKRLVAVRPNGLE 720 +VFAFAPPAVAELGNATGFDLML+D ANLGHAALMQARNQLL TL++D RLVAVRPNG E Sbjct: 661 RVFAFAPPAVAELGNATGFDLMLQDRANLGHAALMQARNQLLGTLSQDPRLVAVRPNGQE 720 Query: 721 DTPEFRLQVDTEKAGALGVSMSDINDTIATAWGSSYVNDFIDKGRVKKVMLQADAQYRML 780 DTPEF+LQ+D KA LG+S+SDIN T+ATAWGSSYVNDFID+GRVKKVMLQADA +RM Sbjct: 721 DTPEFQLQIDAHKAETLGLSISDINSTLATAWGSSYVNDFIDRGRVKKVMLQADAPFRMN 780 Query: 781 PSDLDRWYVRNSAGTMVPFSAFSSAHWTSGSPRLERYNGVPSMEILGMALPGAASSGQAM 840 P D+D+WYVRNSAGTMVPF+AF+ W+SGSPRLERYNGVPSMEILGMA PG+ASSG+A+ Sbjct: 781 PEDIDKWYVRNSAGTMVPFTAFARVDWSSGSPRLERYNGVPSMEILGMAKPGSASSGEAL 840 Query: 841 DIVEAALAKMPPGIGYEWTGLSLQEKASSGKTGILYSISILIVFLALAALYESWAVPFSV 900 IVEAA+ K+P GIGY WTGLSLQEKASSG+T +LY++SILIVFL LAALYESWA+PFSV Sbjct: 841 AIVEAAVTKLPAGIGYAWTGLSLQEKASSGQTTLLYTLSILIVFLCLAALYESWAIPFSV 900 Query: 901 ILVVPLGVFGALVGAILTWKMNDVYFQVGLLTTIGLACKNAILIVEFAKDLYEHGKNLVE 960 I+VVPLGV GAL+GAILTWKMNDVYFQVGLLTTIGLA KNAILIVEFAK+L G +VE Sbjct: 901 IMVVPLGVLGALLGAILTWKMNDVYFQVGLLTTIGLASKNAILIVEFAKELNAQGMRVVE 960 Query: 961 ATMEAVRMRLRPILMTSMAFILGVLPMVLGSGAGAGAQHALGTAVIGGMLSGTLLAIFFV 1020 A M A RMRLRPILMTS+AFILGV+PMV GSGAGAGAQHALGTAVIGGMLSGT+LAIFFV Sbjct: 961 AAMTAARMRLRPILMTSLAFILGVVPMVTGSGAGAGAQHALGTAVIGGMLSGTVLAIFFV 1020 Query: 1021 PLFFVIIMKLF 1031 PLFFV++ LF Sbjct: 1021 PLFFVLVRGLF 1031 >STM0475 [V] COG0841 Cation/multidrug efflux pump Sty Salmonella typhimurium LT2 Length = 1049 Score = 1377 bits (3563), Expect = 0.0, Method: Compositional matrix adjust. Identities = 682/1052 (64%), Positives = 834/1052 (79%), Gaps = 7/1052 (0%) Query: 1 MARFFIDRPIFAWVLAIIVMLAGAISVLTLPIAQYPAIAPPAIAITANYPGASAKTLEDT 60 M FFIDRPIFAWV+AII+MLAG +++L LP+AQYP IAPPA+ I+A YPGA AKT++DT Sbjct: 1 MPNFFIDRPIFAWVIAIIIMLAGGLAILKLPVAQYPTIAPPAVTISATYPGADAKTVQDT 60 Query: 61 VTQVIEQKMKGLDRLSYMASTSESSGTVTITLTFENGTNPDTAQVQVQNKLSLATPLLPT 120 VTQVIEQ M G+D L YM+S S+S+GTV ITLTFE+GT+ D AQVQVQNKL LA PLLP Sbjct: 61 VTQVIEQNMNGIDNLMYMSSNSDSTGTVQITLTFESGTDADIAQVQVQNKLQLAMPLLPQ 120 Query: 121 EVQQQGITVTKSATNFLNVLAFTSEDGSMSGSDLSDYVAANVQDAISRVQGVGDTTLFGS 180 EVQQQG++V KS+++FL V+ + DG+M+ D+SDYVAAN++D ISR GVGD LFGS Sbjct: 121 EVQQQGVSVEKSSSSFLMVVGVINTDGTMTQEDISDYVAANMKDPISRTSGVGDVQLFGS 180 Query: 181 QYAMRIWLDPNKLNSYALTPLDVKNAIQAQNVQVSSGQLGGLPAVENQQINATITAQTRL 240 QYAMRIW++P +L Y LTP+DV NAI+AQN QV++GQLGG P V+ QQ+NA+I AQTRL Sbjct: 181 QYAMRIWMNPTELTKYQLTPVDVINAIKAQNAQVAAGQLGGTPPVKGQQLNASIIAQTRL 240 Query: 241 RTADQFRNIVLRTLTGGAQVKLRDVARIELGSESYTSVGRYNGKPAAGLAIKLATGANAL 300 + D+F I+L+ G+QV+LRDVA+IELG E+Y + ++NG+PA+GL IKLATGANAL Sbjct: 241 TSTDEFGKILLKVNQDGSQVRLRDVAKIELGGENYDVIAKFNGQPASGLGIKLATGANAL 300 Query: 301 DTVKAIDARVAQLEKFFPAGMKVQKPYDTTPFVRISIEEVVRTLVEAVVLVFLVMYLFLQ 360 DT AI A + ++E FFP GMK+ PYDTTPFV+ISI EVV+TLVEA++LVFLVMYLFLQ Sbjct: 301 DTATAIRAELKKMEPFFPPGMKIVYPYDTTPFVKISIHEVVKTLVEAIILVFLVMYLFLQ 360 Query: 361 NFRATLIPTIAVPVVLLGTFGVLAAFGFTINTLTMFAMVLAIGLLVDDAIVVVENVERVM 420 NFRATLIPTIAVPVVLLGTF VLAAFGF+INTLTMF MVLAIGLLVDDAIVVVENVERVM Sbjct: 361 NFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFGMVLAIGLLVDDAIVVVENVERVM 420 Query: 421 SEDGLPPKEATRKSMGQITGALVGVALVLAAVFVPMAFFSGSTGVIYRQFSITIVSAMTL 480 +E+GLPPKEATRKSMGQI GALVG+A+VL+AVF+PMAFF GSTG IYRQFSITIVSAM L Sbjct: 421 TEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFIPMAFFGGSTGAIYRQFSITIVSAMAL 480 Query: 481 SVLVAIVLTPALCATLLKPAAKG-HALATSGFFGWFNRQFDRGNRRYQGVVRHMLGRGWR 539 SVLVA++LTPALCAT+LKP AKG H GFFGWFNR FD+ Y V ++L R Sbjct: 481 SVLVALILTPALCATMLKPVAKGDHGEGKKGFFGWFNRLFDKSTHHYTDSVGNILRSTGR 540 Query: 540 YMAAYAVLLALVVTGFMKLPVGFLPDEDQGSLFAIMQLPAGATKARTDDVIHQVEHHFLV 599 Y+ Y +++ + F++LP FLPDEDQG ++QLPAGAT+ RT V+ +V ++L Sbjct: 541 YLLLYLIIVVGMAYLFVRLPSSFLPDEDQGVFLTMVQLPAGATQERTQKVLDEVTDYYLN 600 Query: 600 DQKDAVAGVFSVSGFSFAGSGQNMGFAFIKLKPWDERKGPGLSVTDVVNKAGAAFAKIRD 659 +K V VF+V+GF FAG GQN G AF+ LK W +R G V + +A AAF++I+D Sbjct: 601 KEKANVESVFAVNGFGFAGRGQNTGIAFVSLKDWADRPGEKNKVEAITQRATAAFSQIKD 660 Query: 660 AKVFAFAPPAVAELGNATGFDLMLKDEANLGHAALMQARNQLLATLTK-DKRLVAVRPNG 718 A VFAF PA+ ELG ATGFD L D+A LGH L QARNQL + K LV VRPNG Sbjct: 661 AMVFAFNLPAIVELGTATGFDFELIDQAGLGHEKLTQARNQLFGEVAKYPDLLVGVRPNG 720 Query: 719 LEDTPEFRLQVDTEKAGALGVSMSDINDTIATAWGSSYVNDFIDKGRVKKVMLQADAQYR 778 LEDTP+F++ +D EKA ALGVS+SDIN T+ AWG SYVNDFID+GRVKKV + ++A+YR Sbjct: 721 LEDTPQFKIDIDQEKAQALGVSISDINTTLGAAWGGSYVNDFIDRGRVKKVYVMSEAKYR 780 Query: 779 MLPSDLDRWYVRNSAGTMVPFSAFSSAHWTSGSPRLERYNGVPSMEILGMALPGAASSGQ 838 MLP D++ WYVR S G MVPFSAFSS+ W GSPRLERYNG+PSMEILG A PG S+G+ Sbjct: 781 MLPDDINDWYVRGSDGQMVPFSAFSSSRWEYGSPRLERYNGLPSMEILGQAAPG-KSTGE 839 Query: 839 AMDIVEAALAKMPPGIGYEWTGLSLQEKASSGKTGILYSISILIVFLALAALYESWAVPF 898 AM ++E +K+P GIGY+WTG+S QE+ S + LY+IS+++VFL LAALYESW++PF Sbjct: 840 AMAMMEELASKLPSGIGYDWTGMSYQERLSGNQAPALYAISLIVVFLCLAALYESWSIPF 899 Query: 899 SVILVVPLGVFGALVGAILTWKMNDVYFQVGLLTTIGLACKNAILIVEFAKDLYE-HGKN 957 SV+LVVPLGV GAL+ A NDVYFQVGLLTTIGL+ KNAILIVEFAKDL + GK Sbjct: 900 SVMLVVPLGVIGALLAATFRGLTNDVYFQVGLLTTIGLSAKNAILIVEFAKDLMDKEGKG 959 Query: 958 LVEATMEAVRMRLRPILMTSMAFILGVLPMVLGSGAGAGAQHALGTAVIGGMLSGTLLAI 1017 LVEAT+EAVRMRLRPILMTS+AF+LGV+P+V+ SGAG+GAQ+A+GT V+GGM++ T+LAI Sbjct: 960 LVEATLEAVRMRLRPILMTSLAFMLGVMPLVISSGAGSGAQNAVGTGVLGGMVTATVLAI 1019 Query: 1018 FFVPLFFVIIMKLFARKPHAAPQGQPAISTEH 1049 FFVP+FFV++ + F+RK STEH Sbjct: 1020 FFVPVFFVVVRRRFSRKSEDIEHSH---STEH 1048 >acrB [V] COG0841 Cation/multidrug efflux pump Eco Escherichia coli K12 Length = 1049 Score = 1370 bits (3546), Expect = 0.0, Method: Compositional matrix adjust. Identities = 663/1020 (65%), Positives = 820/1020 (80%), Gaps = 4/1020 (0%) Query: 1 MARFFIDRPIFAWVLAIIVMLAGAISVLTLPIAQYPAIAPPAIAITANYPGASAKTLEDT 60 M FFIDRPIFAWV+AII+MLAG +++L LP+AQYP IAPPA+ I+A+YPGA AKT++DT Sbjct: 1 MPNFFIDRPIFAWVIAIIIMLAGGLAILKLPVAQYPTIAPPAVTISASYPGADAKTVQDT 60 Query: 61 VTQVIEQKMKGLDRLSYMASTSESSGTVTITLTFENGTNPDTAQVQVQNKLSLATPLLPT 120 VTQVIEQ M G+D L YM+S S+S+GTV ITLTFE+GT+ D AQVQVQNKL LA PLLP Sbjct: 61 VTQVIEQNMNGIDNLMYMSSNSDSTGTVQITLTFESGTDADIAQVQVQNKLQLAMPLLPQ 120 Query: 121 EVQQQGITVTKSATNFLNVLAFTSEDGSMSGSDLSDYVAANVQDAISRVQGVGDTTLFGS 180 EVQQQG++V KS+++FL V+ + DG+M+ D+SDYVAAN++DAISR GVGD LFGS Sbjct: 121 EVQQQGVSVEKSSSSFLMVVGVINTDGTMTQEDISDYVAANMKDAISRTSGVGDVQLFGS 180 Query: 181 QYAMRIWLDPNKLNSYALTPLDVKNAIQAQNVQVSSGQLGGLPAVENQQINATITAQTRL 240 QYAMRIW++PN+LN + LTP+DV AI+AQN QV++GQLGG P V+ QQ+NA+I AQTRL Sbjct: 181 QYAMRIWMNPNELNKFQLTPVDVITAIKAQNAQVAAGQLGGTPPVKGQQLNASIIAQTRL 240 Query: 241 RTADQFRNIVLRTLTGGAQVKLRDVARIELGSESYTSVGRYNGKPAAGLAIKLATGANAL 300 + ++F I+L+ G++V LRDVA+IELG E+Y + +NG+PA+GL IKLATGANAL Sbjct: 241 TSTEEFGKILLKVNQDGSRVLLRDVAKIELGGENYDIIAEFNGQPASGLGIKLATGANAL 300 Query: 301 DTVKAIDARVAQLEKFFPAGMKVQKPYDTTPFVRISIEEVVRTLVEAVVLVFLVMYLFLQ 360 DT AI A +A++E FFP+G+K+ PYDTTPFV+ISI EVV+TLVEA++LVFLVMYLFLQ Sbjct: 301 DTAAAIRAELAKMEPFFPSGLKIVYPYDTTPFVKISIHEVVKTLVEAIILVFLVMYLFLQ 360 Query: 361 NFRATLIPTIAVPVVLLGTFGVLAAFGFTINTLTMFAMVLAIGLLVDDAIVVVENVERVM 420 NFRATLIPTIAVPVVLLGTF VLAAFGF+INTLTMF MVLAIGLLVDDAIVVVENVERVM Sbjct: 361 NFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFGMVLAIGLLVDDAIVVVENVERVM 420 Query: 421 SEDGLPPKEATRKSMGQITGALVGVALVLAAVFVPMAFFSGSTGVIYRQFSITIVSAMTL 480 +E+GLPPKEATRKSMGQI GALVG+A+VL+AVFVPMAFF GSTG IYRQFSITIVSAM L Sbjct: 421 AEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGSTGAIYRQFSITIVSAMAL 480 Query: 481 SVLVAIVLTPALCATLLKPAAKG-HALATSGFFGWFNRQFDRGNRRYQGVVRHMLGRGWR 539 SVLVA++LTPALCAT+LKP AKG H GFFGWFNR F++ Y V +L R Sbjct: 481 SVLVALILTPALCATMLKPIAKGDHGEGKKGFFGWFNRMFEKSTHHYTDSVGGILRSTGR 540 Query: 540 YMAAYAVLLALVVTGFMKLPVGFLPDEDQGSLFAIMQLPAGATKARTDDVIHQVEHHFLV 599 Y+ Y +++ + F++LP FLPDEDQG ++QLPAGAT+ RT V+++V H++L Sbjct: 541 YLVLYLIIVVGMAYLFVRLPSSFLPDEDQGVFMTMVQLPAGATQERTQKVLNEVTHYYLT 600 Query: 600 DQKDAVAGVFSVSGFSFAGSGQNMGFAFIKLKPWDERKGPGLSVTDVVNKAGAAFAKIRD 659 +K+ V VF+V+GF FAG GQN G AF+ LK W +R G V + +A AF++I+D Sbjct: 601 KEKNNVESVFAVNGFGFAGRGQNTGIAFVSLKDWADRPGEENKVEAITMRATRAFSQIKD 660 Query: 660 AKVFAFAPPAVAELGNATGFDLMLKDEANLGHAALMQARNQLLATLTKD-KRLVAVRPNG 718 A VFAF PA+ ELG ATGFD L D+A LGH L QARNQLLA K L +VRPNG Sbjct: 661 AMVFAFNLPAIVELGTATGFDFELIDQAGLGHEKLTQARNQLLAEAAKHPDMLTSVRPNG 720 Query: 719 LEDTPEFRLQVDTEKAGALGVSMSDINDTIATAWGSSYVNDFIDKGRVKKVMLQADAQYR 778 LEDTP+F++ +D EKA ALGVS++DIN T+ AWG SYVNDFID+GRVKKV + ++A+YR Sbjct: 721 LEDTPQFKIDIDQEKAQALGVSINDINTTLGAAWGGSYVNDFIDRGRVKKVYVMSEAKYR 780 Query: 779 MLPSDLDRWYVRNSAGTMVPFSAFSSAHWTSGSPRLERYNGVPSMEILGMALPGAASSGQ 838 MLP D+ WYVR + G MVPFSAFSS+ W GSPRLERYNG+PSMEILG A PG S+G+ Sbjct: 781 MLPDDIGDWYVRAADGQMVPFSAFSSSRWEYGSPRLERYNGLPSMEILGQAAPG-KSTGE 839 Query: 839 AMDIVEAALAKMPPGIGYEWTGLSLQEKASSGKTGILYSISILIVFLALAALYESWAVPF 898 AM+++E +K+P G+GY+WTG+S QE+ S + LY+IS+++VFL LAALYESW++PF Sbjct: 840 AMELMEQLASKLPTGVGYDWTGMSYQERLSGNQAPSLYAISLIVVFLCLAALYESWSIPF 899 Query: 899 SVILVVPLGVFGALVGAILTWKMNDVYFQVGLLTTIGLACKNAILIVEFAKDLYE-HGKN 957 SV+LVVPLGV GAL+ A NDVYFQVGLLTTIGL+ KNAILIVEFAKDL + GK Sbjct: 900 SVMLVVPLGVIGALLAATFRGLTNDVYFQVGLLTTIGLSAKNAILIVEFAKDLMDKEGKG 959 Query: 958 LVEATMEAVRMRLRPILMTSMAFILGVLPMVLGSGAGAGAQHALGTAVIGGMLSGTLLAI 1017 L+EAT++AVRMRLRPILMTS+AFILGV+P+V+ +GAG+GAQ+A+GT V+GGM++ T+LAI Sbjct: 960 LIEATLDAVRMRLRPILMTSLAFILGVMPLVISTGAGSGAQNAVGTGVMGGMVTATVLAI 1019 Score = 39.7 bits (91), Expect = 0.034, Method: Compositional matrix adjust. Identities = 57/237 (24%), Positives = 98/237 (41%), Gaps = 23/237 (9%) Query: 814 LERYNGVPSMEILGMALPGAASSGQAMDIVEAALAKMPP------GIGYEW-----TGLS 862 + +NG P+ LG+ L A++ + A LAKM P I Y + +S Sbjct: 278 IAEFNGQPASG-LGIKLATGANALDTAAAIRAELAKMEPFFPSGLKIVYPYDTTPFVKIS 336 Query: 863 LQEKASSGKTGILYSISILIVFLA--LAALYESWAVPFSVILVVPLGVFGALVGAILTWK 920 + E + I+ ++ +FL A L + AVP VV LG F L A + Sbjct: 337 IHEVVKTLVEAIILVFLVMYLFLQNFRATLIPTIAVP-----VVLLGTFAVL--AAFGFS 389 Query: 921 MNDVYFQVGLLTTIGLACKNAILIVE-FAKDLYEHGKNLVEATMEAVRMRLRPILMTSMA 979 +N + G++ IGL +AI++VE + + E G EAT +++ ++ +M Sbjct: 390 INTLTM-FGMVLAIGLLVDDAIVVVENVERVMAEEGLPPKEATRKSMGQIQGALVGIAMV 448 Query: 980 FILGVLPMVLGSGAGAGAQHALGTAVIGGMLSGTLLAIFFVPLFFVIIMKLFARKPH 1036 +PM G+ ++ M L+A+ P ++K A+ H Sbjct: 449 LSAVFVPMAFFGGSTGAIYRQFSITIVSAMALSVLVALILTPALCATMLKPIAKGDH 505 >ZacrB [V] COG0841 Cation/multidrug efflux pump EcZ Escherichia coli O157:H7 EDL933 Length = 1049 Score = 1369 bits (3544), Expect = 0.0, Method: Compositional matrix adjust. Identities = 662/1020 (64%), Positives = 820/1020 (80%), Gaps = 4/1020 (0%) Query: 1 MARFFIDRPIFAWVLAIIVMLAGAISVLTLPIAQYPAIAPPAIAITANYPGASAKTLEDT 60 M FFIDRPIFAWV+AII+MLAG +++L LP+AQYP IAPPA+ I+A+YPGA AKT++DT Sbjct: 1 MPNFFIDRPIFAWVIAIIIMLAGGLAILKLPVAQYPTIAPPAVTISASYPGADAKTVQDT 60 Query: 61 VTQVIEQKMKGLDRLSYMASTSESSGTVTITLTFENGTNPDTAQVQVQNKLSLATPLLPT 120 VTQVIEQ M G+D L YM+S S+S+GTV ITLTFE+GT+ D AQVQVQNKL LA PLLP Sbjct: 61 VTQVIEQNMNGIDNLMYMSSNSDSTGTVQITLTFESGTDADIAQVQVQNKLQLAMPLLPQ 120 Query: 121 EVQQQGITVTKSATNFLNVLAFTSEDGSMSGSDLSDYVAANVQDAISRVQGVGDTTLFGS 180 EVQQQG+++ KS+++FL V+ + DG+M+ D+SDYVAAN++DAISR GVGD LFGS Sbjct: 121 EVQQQGVSIEKSSSSFLMVVGVINTDGTMTQEDISDYVAANMKDAISRTSGVGDVQLFGS 180 Query: 181 QYAMRIWLDPNKLNSYALTPLDVKNAIQAQNVQVSSGQLGGLPAVENQQINATITAQTRL 240 QYAMRIW++PN+LN + LTP+DV AI+AQN QV++GQLGG P V+ QQ+NA+I AQTRL Sbjct: 181 QYAMRIWMNPNELNKFQLTPVDVITAIKAQNAQVAAGQLGGTPPVKGQQLNASIIAQTRL 240 Query: 241 RTADQFRNIVLRTLTGGAQVKLRDVARIELGSESYTSVGRYNGKPAAGLAIKLATGANAL 300 + ++F I+L+ G++V LRDVA+IELG E+Y + +NG+PA+GL IKLATGANAL Sbjct: 241 TSTEEFGKILLKVNQDGSRVLLRDVAKIELGGENYDIIAEFNGQPASGLGIKLATGANAL 300 Query: 301 DTVKAIDARVAQLEKFFPAGMKVQKPYDTTPFVRISIEEVVRTLVEAVVLVFLVMYLFLQ 360 DT AI A +A++E FFP+G+K+ PYDTTPFV+ISI EVV+TLVEA++LVFLVMYLFLQ Sbjct: 301 DTAAAIRAELAKMEPFFPSGLKIVYPYDTTPFVKISIHEVVKTLVEAIILVFLVMYLFLQ 360 Query: 361 NFRATLIPTIAVPVVLLGTFGVLAAFGFTINTLTMFAMVLAIGLLVDDAIVVVENVERVM 420 NFRATLIPTIAVPVVLLGTF VLAAFGF+INTLTMF MVLAIGLLVDDAIVVVENVERVM Sbjct: 361 NFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFGMVLAIGLLVDDAIVVVENVERVM 420 Query: 421 SEDGLPPKEATRKSMGQITGALVGVALVLAAVFVPMAFFSGSTGVIYRQFSITIVSAMTL 480 +E+GLPPKEATRKSMGQI GALVG+A+VL+AVFVPMAFF GSTG IYRQFSITIVSAM L Sbjct: 421 AEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGSTGAIYRQFSITIVSAMAL 480 Query: 481 SVLVAIVLTPALCATLLKPAAKG-HALATSGFFGWFNRQFDRGNRRYQGVVRHMLGRGWR 539 SVLVA++LTPALCAT+LKP AKG H GFFGWFNR F++ Y V +L R Sbjct: 481 SVLVALILTPALCATMLKPIAKGDHGEGKKGFFGWFNRMFEKSTHHYTDSVGGILRSTGR 540 Query: 540 YMAAYAVLLALVVTGFMKLPVGFLPDEDQGSLFAIMQLPAGATKARTDDVIHQVEHHFLV 599 Y+ Y +++ + F++LP FLPDEDQG ++QLPAGAT+ RT V+++V H++L Sbjct: 541 YLVLYLIIVVGMAYLFVRLPSSFLPDEDQGVFMTMVQLPAGATQERTQKVLNEVTHYYLT 600 Query: 600 DQKDAVAGVFSVSGFSFAGSGQNMGFAFIKLKPWDERKGPGLSVTDVVNKAGAAFAKIRD 659 +K+ V VF+V+GF FAG GQN G AF+ LK W +R G V + +A AF++I+D Sbjct: 601 KEKNNVESVFAVNGFGFAGRGQNTGIAFVSLKDWADRPGEENKVEAITMRATRAFSQIKD 660 Query: 660 AKVFAFAPPAVAELGNATGFDLMLKDEANLGHAALMQARNQLLATLTKD-KRLVAVRPNG 718 A VFAF PA+ ELG ATGFD L D+A LGH L QARNQLLA K L +VRPNG Sbjct: 661 AMVFAFNLPAIVELGTATGFDFELIDQAGLGHEKLTQARNQLLAEAAKHPDMLTSVRPNG 720 Query: 719 LEDTPEFRLQVDTEKAGALGVSMSDINDTIATAWGSSYVNDFIDKGRVKKVMLQADAQYR 778 LEDTP+F++ +D EKA ALGVS++DIN T+ AWG SYVNDFID+GRVKKV + ++A+YR Sbjct: 721 LEDTPQFKIDIDQEKAQALGVSINDINTTLGAAWGGSYVNDFIDRGRVKKVYVMSEAKYR 780 Query: 779 MLPSDLDRWYVRNSAGTMVPFSAFSSAHWTSGSPRLERYNGVPSMEILGMALPGAASSGQ 838 MLP D+ WYVR + G MVPFSAFSS+ W GSPRLERYNG+PSMEILG A PG S+G+ Sbjct: 781 MLPDDIGDWYVRAADGQMVPFSAFSSSRWEYGSPRLERYNGLPSMEILGQAAPG-KSTGE 839 Query: 839 AMDIVEAALAKMPPGIGYEWTGLSLQEKASSGKTGILYSISILIVFLALAALYESWAVPF 898 AM+++E +K+P G+GY+WTG+S QE+ S + LY+IS+++VFL LAALYESW++PF Sbjct: 840 AMELMEQLASKLPTGVGYDWTGMSYQERLSGNQAPSLYAISLIVVFLCLAALYESWSIPF 899 Query: 899 SVILVVPLGVFGALVGAILTWKMNDVYFQVGLLTTIGLACKNAILIVEFAKDLYE-HGKN 957 SV+LVVPLGV GAL+ A NDVYFQVGLLTTIGL+ KNAILIVEFAKDL + GK Sbjct: 900 SVMLVVPLGVIGALLAATFRGLTNDVYFQVGLLTTIGLSAKNAILIVEFAKDLMDKEGKG 959 Query: 958 LVEATMEAVRMRLRPILMTSMAFILGVLPMVLGSGAGAGAQHALGTAVIGGMLSGTLLAI 1017 L+EAT++AVRMRLRPILMTS+AFILGV+P+V+ +GAG+GAQ+A+GT V+GGM++ T+LAI Sbjct: 960 LIEATLDAVRMRLRPILMTSLAFILGVMPLVISTGAGSGAQNAVGTGVMGGMVTATVLAI 1019 Score = 40.0 bits (92), Expect = 0.034, Method: Compositional matrix adjust. Identities = 57/237 (24%), Positives = 98/237 (41%), Gaps = 23/237 (9%) Query: 814 LERYNGVPSMEILGMALPGAASSGQAMDIVEAALAKMPP------GIGYEW-----TGLS 862 + +NG P+ LG+ L A++ + A LAKM P I Y + +S Sbjct: 278 IAEFNGQPASG-LGIKLATGANALDTAAAIRAELAKMEPFFPSGLKIVYPYDTTPFVKIS 336 Query: 863 LQEKASSGKTGILYSISILIVFLA--LAALYESWAVPFSVILVVPLGVFGALVGAILTWK 920 + E + I+ ++ +FL A L + AVP VV LG F L A + Sbjct: 337 IHEVVKTLVEAIILVFLVMYLFLQNFRATLIPTIAVP-----VVLLGTFAVL--AAFGFS 389 Query: 921 MNDVYFQVGLLTTIGLACKNAILIVE-FAKDLYEHGKNLVEATMEAVRMRLRPILMTSMA 979 +N + G++ IGL +AI++VE + + E G EAT +++ ++ +M Sbjct: 390 INTLTM-FGMVLAIGLLVDDAIVVVENVERVMAEEGLPPKEATRKSMGQIQGALVGIAMV 448 Query: 980 FILGVLPMVLGSGAGAGAQHALGTAVIGGMLSGTLLAIFFVPLFFVIIMKLFARKPH 1036 +PM G+ ++ M L+A+ P ++K A+ H Sbjct: 449 LSAVFVPMAFFGGSTGAIYRQFSITIVSAMALSVLVALILTPALCATMLKPIAKGDH 505 >ECs0515 [V] COG0841 Cation/multidrug efflux pump Ecs Escherichia coli O157:H7 Length = 1049 Score = 1369 bits (3544), Expect = 0.0, Method: Compositional matrix adjust. Identities = 662/1020 (64%), Positives = 820/1020 (80%), Gaps = 4/1020 (0%) Query: 1 MARFFIDRPIFAWVLAIIVMLAGAISVLTLPIAQYPAIAPPAIAITANYPGASAKTLEDT 60 M FFIDRPIFAWV+AII+MLAG +++L LP+AQYP IAPPA+ I+A+YPGA AKT++DT Sbjct: 1 MPNFFIDRPIFAWVIAIIIMLAGGLAILKLPVAQYPTIAPPAVTISASYPGADAKTVQDT 60 Query: 61 VTQVIEQKMKGLDRLSYMASTSESSGTVTITLTFENGTNPDTAQVQVQNKLSLATPLLPT 120 VTQVIEQ M G+D L YM+S S+S+GTV ITLTFE+GT+ D AQVQVQNKL LA PLLP Sbjct: 61 VTQVIEQNMNGIDNLMYMSSNSDSTGTVQITLTFESGTDADIAQVQVQNKLQLAMPLLPQ 120 Query: 121 EVQQQGITVTKSATNFLNVLAFTSEDGSMSGSDLSDYVAANVQDAISRVQGVGDTTLFGS 180 EVQQQG+++ KS+++FL V+ + DG+M+ D+SDYVAAN++DAISR GVGD LFGS Sbjct: 121 EVQQQGVSIEKSSSSFLMVVGVINTDGTMTQEDISDYVAANMKDAISRTSGVGDVQLFGS 180 Query: 181 QYAMRIWLDPNKLNSYALTPLDVKNAIQAQNVQVSSGQLGGLPAVENQQINATITAQTRL 240 QYAMRIW++PN+LN + LTP+DV AI+AQN QV++GQLGG P V+ QQ+NA+I AQTRL Sbjct: 181 QYAMRIWMNPNELNKFQLTPVDVITAIKAQNAQVAAGQLGGTPPVKGQQLNASIIAQTRL 240 Query: 241 RTADQFRNIVLRTLTGGAQVKLRDVARIELGSESYTSVGRYNGKPAAGLAIKLATGANAL 300 + ++F I+L+ G++V LRDVA+IELG E+Y + +NG+PA+GL IKLATGANAL Sbjct: 241 TSTEEFGKILLKVNQDGSRVLLRDVAKIELGGENYDIIAEFNGQPASGLGIKLATGANAL 300 Query: 301 DTVKAIDARVAQLEKFFPAGMKVQKPYDTTPFVRISIEEVVRTLVEAVVLVFLVMYLFLQ 360 DT AI A +A++E FFP+G+K+ PYDTTPFV+ISI EVV+TLVEA++LVFLVMYLFLQ Sbjct: 301 DTAAAIRAELAKMEPFFPSGLKIVYPYDTTPFVKISIHEVVKTLVEAIILVFLVMYLFLQ 360 Query: 361 NFRATLIPTIAVPVVLLGTFGVLAAFGFTINTLTMFAMVLAIGLLVDDAIVVVENVERVM 420 NFRATLIPTIAVPVVLLGTF VLAAFGF+INTLTMF MVLAIGLLVDDAIVVVENVERVM Sbjct: 361 NFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFGMVLAIGLLVDDAIVVVENVERVM 420 Query: 421 SEDGLPPKEATRKSMGQITGALVGVALVLAAVFVPMAFFSGSTGVIYRQFSITIVSAMTL 480 +E+GLPPKEATRKSMGQI GALVG+A+VL+AVFVPMAFF GSTG IYRQFSITIVSAM L Sbjct: 421 AEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGSTGAIYRQFSITIVSAMAL 480 Query: 481 SVLVAIVLTPALCATLLKPAAKG-HALATSGFFGWFNRQFDRGNRRYQGVVRHMLGRGWR 539 SVLVA++LTPALCAT+LKP AKG H GFFGWFNR F++ Y V +L R Sbjct: 481 SVLVALILTPALCATMLKPIAKGDHGEGKKGFFGWFNRMFEKSTHHYTDSVGGILRSTGR 540 Query: 540 YMAAYAVLLALVVTGFMKLPVGFLPDEDQGSLFAIMQLPAGATKARTDDVIHQVEHHFLV 599 Y+ Y +++ + F++LP FLPDEDQG ++QLPAGAT+ RT V+++V H++L Sbjct: 541 YLVLYLIIVVGMAYLFVRLPSSFLPDEDQGVFMTMVQLPAGATQERTQKVLNEVTHYYLT 600 Query: 600 DQKDAVAGVFSVSGFSFAGSGQNMGFAFIKLKPWDERKGPGLSVTDVVNKAGAAFAKIRD 659 +K+ V VF+V+GF FAG GQN G AF+ LK W +R G V + +A AF++I+D Sbjct: 601 KEKNNVESVFAVNGFGFAGRGQNTGIAFVSLKDWADRPGEENKVEAITMRATRAFSQIKD 660 Query: 660 AKVFAFAPPAVAELGNATGFDLMLKDEANLGHAALMQARNQLLATLTKD-KRLVAVRPNG 718 A VFAF PA+ ELG ATGFD L D+A LGH L QARNQLLA K L +VRPNG Sbjct: 661 AMVFAFNLPAIVELGTATGFDFELIDQAGLGHEKLTQARNQLLAEAAKHPDMLTSVRPNG 720 Query: 719 LEDTPEFRLQVDTEKAGALGVSMSDINDTIATAWGSSYVNDFIDKGRVKKVMLQADAQYR 778 LEDTP+F++ +D EKA ALGVS++DIN T+ AWG SYVNDFID+GRVKKV + ++A+YR Sbjct: 721 LEDTPQFKIDIDQEKAQALGVSINDINTTLGAAWGGSYVNDFIDRGRVKKVYVMSEAKYR 780 Query: 779 MLPSDLDRWYVRNSAGTMVPFSAFSSAHWTSGSPRLERYNGVPSMEILGMALPGAASSGQ 838 MLP D+ WYVR + G MVPFSAFSS+ W GSPRLERYNG+PSMEILG A PG S+G+ Sbjct: 781 MLPDDIGDWYVRAADGQMVPFSAFSSSRWEYGSPRLERYNGLPSMEILGQAAPG-KSTGE 839 Query: 839 AMDIVEAALAKMPPGIGYEWTGLSLQEKASSGKTGILYSISILIVFLALAALYESWAVPF 898 AM+++E +K+P G+GY+WTG+S QE+ S + LY+IS+++VFL LAALYESW++PF Sbjct: 840 AMELMEQLASKLPTGVGYDWTGMSYQERLSGNQAPSLYAISLIVVFLCLAALYESWSIPF 899 Query: 899 SVILVVPLGVFGALVGAILTWKMNDVYFQVGLLTTIGLACKNAILIVEFAKDLYE-HGKN 957 SV+LVVPLGV GAL+ A NDVYFQVGLLTTIGL+ KNAILIVEFAKDL + GK Sbjct: 900 SVMLVVPLGVIGALLAATFRGLTNDVYFQVGLLTTIGLSAKNAILIVEFAKDLMDKEGKG 959 Query: 958 LVEATMEAVRMRLRPILMTSMAFILGVLPMVLGSGAGAGAQHALGTAVIGGMLSGTLLAI 1017 L+EAT++AVRMRLRPILMTS+AFILGV+P+V+ +GAG+GAQ+A+GT V+GGM++ T+LAI Sbjct: 960 LIEATLDAVRMRLRPILMTSLAFILGVMPLVISTGAGSGAQNAVGTGVMGGMVTATVLAI 1019 Score = 40.0 bits (92), Expect = 0.034, Method: Compositional matrix adjust. Identities = 57/237 (24%), Positives = 98/237 (41%), Gaps = 23/237 (9%) Query: 814 LERYNGVPSMEILGMALPGAASSGQAMDIVEAALAKMPP------GIGYEW-----TGLS 862 + +NG P+ LG+ L A++ + A LAKM P I Y + +S Sbjct: 278 IAEFNGQPASG-LGIKLATGANALDTAAAIRAELAKMEPFFPSGLKIVYPYDTTPFVKIS 336 Query: 863 LQEKASSGKTGILYSISILIVFLA--LAALYESWAVPFSVILVVPLGVFGALVGAILTWK 920 + E + I+ ++ +FL A L + AVP VV LG F L A + Sbjct: 337 IHEVVKTLVEAIILVFLVMYLFLQNFRATLIPTIAVP-----VVLLGTFAVL--AAFGFS 389 Query: 921 MNDVYFQVGLLTTIGLACKNAILIVE-FAKDLYEHGKNLVEATMEAVRMRLRPILMTSMA 979 +N + G++ IGL +AI++VE + + E G EAT +++ ++ +M Sbjct: 390 INTLTM-FGMVLAIGLLVDDAIVVVENVERVMAEEGLPPKEATRKSMGQIQGALVGIAMV 448 Query: 980 FILGVLPMVLGSGAGAGAQHALGTAVIGGMLSGTLLAIFFVPLFFVIIMKLFARKPH 1036 +PM G+ ++ M L+A+ P ++K A+ H Sbjct: 449 LSAVFVPMAFFGGSTGAIYRQFSITIVSAMALSVLVALILTPALCATMLKPIAKGDH 505