BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.1131.p (453 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PA4900 [GEPR] COG0477 Permeases of the major facilitator superfa... 390 e-108 RSc1093 [GEPR] COG0477 Permeases of the major facilitator superf... 273 6e-73 Cgl2967 [GEPR] COG0477 Permeases of the major facilitator superf... 243 8e-64 Cgl1052 [GEPR] COG0477 Permeases of the major facilitator superf... 231 3e-60 AGc4589 [GEPR] COG0477 Permeases of the major facilitator superf... 231 3e-60 >PA4900 [GEPR] COG0477 Permeases of the major facilitator superfamily Pae Pseudomonas aeruginosa Length = 446 Score = 390 bits (1001), Expect = e-108, Method: Compositional matrix adjust. Identities = 218/451 (48%), Positives = 299/451 (66%), Gaps = 12/451 (2%) Query: 1 MKNQEVSQIIDGAGFTRFHWMVMCLCALLLVFDGYDLFIYGAVLPVLMKHWSLSPVQAGA 60 M Q + +ID A F R HW+++ +++FDGYD+ IYG+V+P LM+ W LSPVQAG Sbjct: 1 MNRQSAAAVIDAARFNRTHWLILGWGCFIMLFDGYDMVIYGSVVPRLMQEWQLSPVQAGT 60 Query: 61 LGSYALFGMMFGAFIFGPLADRIGRKKGVAISFVLFSVSTFLSGFSSTPNEFGVYRFLAG 120 LGS ALFGM+FG + PLADR GR++ V + +L S++ FL+G + P E G RF G Sbjct: 61 LGSCALFGMLFGGTLLAPLADRFGRRRLVIATTLLASLAAFLTGHARDPLELGAGRFFTG 120 Query: 121 LGCGGLMPNAVALMNEYAPKRLRSTLVAIMFSGYSLGGVLCAGLGIWMLPNFGWQSMFFA 180 L G L+P+A+ L++E+AP RSTLV +M + YS+G VL A L I M+P +GWQS+F+ Sbjct: 121 LALGALVPSAINLISEFAPAGRRSTLVTVMSAFYSVGAVLSALLAIAMIPAWGWQSVFYV 180 Query: 181 AAVPLVLLPLILWKLPESVGFLLRAGRQEQARAMLAQVAPHLRIDADTQLVQADAKGAGA 240 A +P++ +PL+L LPES FL GR+ + A+L +V P R A+ +A+A A A Sbjct: 181 AVLPVLAVPLMLRWLPESAAFLELKGRRAELDALLRKVDPDYRPGAE----RANAVAAEA 236 Query: 241 P---MLDLFKQDRPVGTLMIWIAFFCCLLMVYALGSWLPKLMASAGYSLGSSLSFLLALN 297 P + LF+ + VGTL++W+AF C+LM Y L +WLPKLMA GY+LGSSL+FL+ LN Sbjct: 237 PSGRVAQLFEGRQAVGTLLLWVAFAMCMLMSYGLNTWLPKLMAGGGYALGSSLAFLVTLN 296 Query: 298 FGGVVGAIGGGWLGDRFTLPKVVVSFFTVGTVAIALLGFNSPTPVLYLLIIVAGATTIGT 357 G +GA+ GGWL DR + +V FF + ++A LG +L L++VAGATTIGT Sbjct: 297 VGATLGALFGGWLADRLGAGRTLVLFFALAAASLAALGLGPGPWLLNGLLVVAGATTIGT 356 Query: 358 QILLYANTAQFYPLASRSTGLGWASGVGRSGAIVGPLLGGALMAAALPLKMNFLVFAIPG 417 +++A AQFYP RSTG+GWA+GVGR GAI GP+LGG+L+A LP + NFL FA PG Sbjct: 357 LAVIHAYAAQFYPAWVRSTGVGWAAGVGRLGAIAGPMLGGSLLALELPFQQNFLAFAAPG 416 Query: 418 LVAALAMGIFMLRYRHARPVTPAAPSVTATS 448 ++ ALA+ H RP PA SV AT+ Sbjct: 417 VIGALAIACI-----HLRPRVPAEASVDATA 442 >RSc1093 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 454 Score = 273 bits (698), Expect = 6e-73, Method: Compositional matrix adjust. Identities = 170/446 (38%), Positives = 258/446 (57%), Gaps = 8/446 (1%) Query: 5 EVSQIIDGAGFTRFHWMVMCLCALLLVFDGYDLFIYGAVLPVLMKHWSLSPVQAGALGSY 64 +V +D F+ F W V+ LC ++ DG+D G + P L + W + P G + S Sbjct: 9 DVRAWLDRQRFSAFQWSVVLLCFFVVAIDGFDTACVGFIAPALAQDWHIGPAVLGTVFSA 68 Query: 65 ALFGMMFGAFIFGPLADRIGRKKGVAISFVLFSVSTFLSGFSSTPNEFGVYRFLAGLGCG 124 L G+M GA IFGPLADRIGRK+ + + F +++ LS F+ + RFL GLG G Sbjct: 69 GLAGLMVGALIFGPLADRIGRKQTLLFTVGAFGLASVLSAFAPSVGALVALRFLTGLGLG 128 Query: 125 GLMPNAVALMNEYAPKRLRSTLVAIMFSGYSLGGVLCAGLGIWMLPNFGWQS-MFFAAAV 183 G MPNA+AL +EY P+R R+ L +MF G++LG + ++P FGW+S + F + Sbjct: 129 GAMPNAIALTSEYCPERRRAFLTTVMFCGFTLGSGFGGIVAAQLVPEFGWRSVLLFGGVI 188 Query: 184 PLVLLPLILWKLPESVGFLLRAGRQEQARA-MLAQVAPHLRIDADTQLV--QADAKGA-G 239 PL+LLP++++ LPESV +L+ G Q A +L ++AP +++ DT+ V + AKGA G Sbjct: 189 PLLLLPVMVFALPESVRYLVAKGGQSAAVGRLLNRIAP-VQVTPDTRFVLHETAAKGAPG 247 Query: 240 APMLDLFKQDRPVGTLMIWIAFFCCLLMVYALGSWLPKLMASAGYSLGSSLSFLLALNFG 299 +P+ LF GTL++W FF LL+VY + +WLP L+ S G +L + + G Sbjct: 248 SPVRQLFLPAFRTGTLLLWSVFFMSLLIVYLMTNWLPTLIHSGGVALALASRIAVMYQLG 307 Query: 300 GVVGAIGGGWLGDRFTLPKVVVSFFTVGTVAIALLGFNSPTPVLYLLIIVAGATTIGTQI 359 G VGA+ G + DR+ V+ + +G + L G + T +L + + G G+QI Sbjct: 308 GTVGALVIGRMMDRYPATVVLCCTYGLGAGFLVLTGVSQGT-MLAIAVTGVGFCISGSQI 366 Query: 360 LLYANTAQFYPLASRSTGLGWASGVGRSGAIVGPLLGGALMAAALPLKMNFLVFAIPGLV 419 A AQFYP ASR TG+ WA G+GR G++ G L+GG L+AA + ++ FL+ A+P + Sbjct: 367 GANAFAAQFYPTASRVTGISWALGIGRLGSVCGALIGGVLLAANIGFQLLFLLVAVPAAI 426 Query: 420 AALAMGIFMLRYRHARPVTPAAPSVT 445 A+LA+ + + RH A P+VT Sbjct: 427 ASLAIFLCGAQARHVE-TQGALPAVT 451 >Cgl2967 [GEPR] COG0477 Permeases of the major facilitator superfamily Cgl Corynebacterium glutamicum Length = 444 Score = 243 bits (619), Expect = 8e-64, Method: Compositional matrix adjust. Identities = 158/418 (37%), Positives = 224/418 (53%), Gaps = 38/418 (9%) Query: 7 SQIIDGAGFTRFHWMVMCLCALLL-----VFDGYDLFIYGAVLPVLMKHWSLSPVQAGAL 61 SQ I+ G T L A+L+ +FDGYDL +YG V L K W+LS G + Sbjct: 23 SQTIENKGLTILGISGRRLAAVLIGWFFVIFDGYDLIVYGTVQSALAKEWNLSSATLGTI 82 Query: 62 GSYALFGMMFGAFIFGPLADRIGRKKGVAISFVLFSVSTFLSGFSSTPNEFGVYRFLAGL 121 GS A FGM GA G L+DR+GRK V S ++ SV T L F+ P FG +RF+AGL Sbjct: 83 GSTAFFGMAIGAVFIGRLSDRVGRKAAVIGSVLILSVFTMLCAFAPNPWVFGAFRFIAGL 142 Query: 122 GCGGLMPNAVALMNEYAPKRLRSTLVAIMFSGYSLGGVLCAGLGIWMLPN---FGWQSMF 178 G GGL+P+ A+ ++ P++ S +M SG +GG + A L + ++P+ +GW+ MF Sbjct: 143 GLGGLVPSVNAMTSDLVPRKTMSAWATVMMSGVPIGGSIAAVLALVVVPSSEEWGWRFMF 202 Query: 179 FAAAVPLVL-LPLILWKLPESVGFLLRAGRQEQARAMLAQVAPHLRIDADTQLVQADAKG 237 A +PLV+ LP+ + +P ++ D D + + G Sbjct: 203 LIALIPLVVGLPIAMKVIPSD---------------------KAIKADHDIREGHDEPAG 241 Query: 238 AGAPMLDLFKQDRPVGTLMIWIAF--FCCLLMVYALGSWLPKLMASAGYSLGSSLSFLLA 295 ++D ++ + IW A F LL Y LG+WLP+LM +AGY G +L F LA Sbjct: 242 FKDLLVDRYRW------ISIWFALATFVTLLAWYGLGTWLPRLMETAGYEFGHALMFTLA 295 Query: 296 LNFGGVVGAIGGGWLGDRFTLPKVVVSFFTVGTVAIALLGFNSPTPVLYLLIIVAGATTI 355 LN G V+G++ W GDRF + V + +A+ LL P +Y+++I+AG T Sbjct: 296 LNLGAVIGSVVTAWAGDRFGPIRSGVIAAGIAGIALLLLLTYPPVTAVYVILILAGVGTH 355 Query: 356 GTQILLYANTAQFYPLASRSTGLGWASGVGRSGAIVGPLLGGALMAAALPLKMNFLVF 413 GTQIL+ A A FYP R T LGWA GVGR GA+V P L G L+A L + NF++F Sbjct: 356 GTQILIIAAVANFYPSNLRGTALGWALGVGRIGAVVAPQLAGLLLAWNLGVNSNFIMF 413 >Cgl1052 [GEPR] COG0477 Permeases of the major facilitator superfamily Cgl Corynebacterium glutamicum Length = 431 Score = 231 bits (589), Expect = 3e-60, Method: Compositional matrix adjust. Identities = 156/419 (37%), Positives = 238/419 (56%), Gaps = 12/419 (2%) Query: 22 VMCLCALLLVFDGYDLFIYGAVLPVLMKH--WSLSPVQAGALGSYALFGMMFGAFIFGPL 79 V+ L +V DG+DL + GA +P +++ W L+ QA + + L GM GA G L Sbjct: 16 VLALLWFAIVLDGFDLVVLGATIPSMLEDPAWDLTAGQATQISTIGLVGMTIGALTIGFL 75 Query: 80 ADRIGRKKGVAISFVLFSVSTFLSGFSSTPNEFGVYRFLAGLGCGGLMPNAVALMNEYAP 139 DR+GR++ + S +FSV T L F++ F ++RFLAG+G GG +P A+A++ E+ P Sbjct: 76 TDRLGRRRVMLFSVAVFSVFTLLLAFTTNVQLFSLWRFLAGVGLGGALPTAIAMVTEFRP 135 Query: 140 KRLRSTLVAIMFSGYSLGGVLCAGLGIWMLPNFGWQSMFFAAAVP-LVLLPLILWKLPES 198 + + +GY +G V A LG++++ FGW SMF A AVP L+LLPL+ + LPES Sbjct: 136 GTKAGSASTTLMTGYHVGAVATAFLGLFLIDGFGWHSMFIAGAVPGLILLPLLYFFLPES 195 Query: 199 VGFLLRAGRQEQARAMLAQVAPHLRIDADTQLVQADAKGAGAPMLDLFKQDRPVGTLMIW 258 +L +G+ ++A+A+ A L +D D + G + + LFK TL IW Sbjct: 196 PQYLKISGKLDEAQAVAASYG--LSLDDDLDREHEEELGESSSLSSLFKPSFRRNTLAIW 253 Query: 259 IAFFCCLLMVYALGSWLPKLMASAGYSLGSSLSFLLALNFGGVVGAIGGGWLGDRFTLPK 318 F LL+VY L +WLP++M A Y +G+SL FL+ LN G V+G G + D+ + K Sbjct: 254 GTSFMGLLLVYGLNTWLPQIMRQADYDMGNSLGFLMVLNIGAVIGLYIAGRIADKNSPRK 313 Query: 319 VVVSFFTVGTVAIALLGFNSPTPVLYLLIIVAGATTIGTQILLYANTAQFYPLASRSTGL 378 + +F ++ALL P LY ++++ G +Q+L+YA + +P R+T + Sbjct: 314 TALVWFVFSAFSLALLAVRMPLIGLYGIVLLTGIFVFSSQVLIYAFVGENHPAKMRATAM 373 Query: 379 GWASGVGRSGAIVGPLLGGALMAAALPLKMNFLVFAIPGLVAALAMGIF----MLRYRH 433 G+++G+GR GAI GPLLGG L++A L F FA GL+ AL IF LR+R Sbjct: 374 GFSAGIGRLGAISGPLLGGLLVSANLAYPWGFFAFAGVGLLGAL---IFSASKTLRHRE 429 >AGc4589 [GEPR] COG0477 Permeases of the major facilitator superfamily Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 477 Score = 231 bits (588), Expect = 3e-60, Method: Compositional matrix adjust. Identities = 159/420 (37%), Positives = 232/420 (55%), Gaps = 26/420 (6%) Query: 22 VMCLCALLLVFDGYDLFIYGAVLPVLMKH--WSLSPVQAGALGSYALFGMMFGAFIFGPL 79 V+ C L+++FDGYDL +YGAV P L+K W+L+P G + L GM+ GA G + Sbjct: 68 VIATCGLMIMFDGYDLVVYGAVAPALLKESTWALNPAMVGRAAALTLVGMLLGALFAGTM 127 Query: 80 ADRIGRKKGVAISFVLFSVSTFLSGFSSTPN--EFGVYRFLAGLGCGGLMPNAVALMNEY 137 ADRIGR+K V +S FS S TPN F + RF AGLG G L+P AL+ E+ Sbjct: 128 ADRIGRRKVVLLSLAGFSAMMIASAM--TPNFLAFEITRFFAGLGLGALLPTVTALVLEF 185 Query: 138 APKRLRSTLVAIMFSGYSLGGVLCAGLGIWMLPNFGWQSMFFAAAVPLVLLPLILWKLPE 197 +P + R+ ++ F GY +GG++ LG+ +L ++GW+ + +PL+LLP+ + LPE Sbjct: 186 SPPQRRAQANSLSFLGYLIGGIISGILGMLLLESYGWRPLMLIGGLPLILLPIFMRFLPE 245 Query: 198 SVGFLLRAGRQEQARAM-----LAQVAPHLRIDADTQLVQADAKGAGAPMLDLFKQDRPV 252 S +L GRQ +A + L ++ PH ++ G GA LF + R Sbjct: 246 SPEWLASKGRQAEADGICDSYGLQRIVPHAKMQKG---------GVGA----LFSEGRLA 292 Query: 253 GTLMIWIAFFCCLLMVYALGSWLPKLMASAGYSLGSSLSFLLALNFGGVVGAIGGGWLGD 312 TL W FC LL+ + + +WLP +M GY + S+LSF + LN G +G + GG D Sbjct: 293 STLNAWGIHFCSLLLTFGMVNWLPTIMNKMGYDISSALSFSVMLNVGAAIGILIGGRFAD 352 Query: 313 RFTLPKVVVSFFTVGTVAIALLGFNSPTPVLYLLIIVAGATTIGTQILLYANTAQFYPLA 372 + + VV F VG +I L N P+LY+ + +AGA TIGTQIL + YP+ Sbjct: 353 KGNVKVVVAILFAVGAASIFALTANK-GPLLYVFVALAGAGTIGTQILANVLVGRLYPVH 411 Query: 373 SRSTGLGWASGVGRSGAIVGPLLGGALMAAALPLKMNFLVFAIPGLVAALAMGIFMLRYR 432 R TGLG++ VGR G I GP++GG ++ L + NF +F +V L + + L YR Sbjct: 412 IRGTGLGFSLAVGRLGGIAGPMIGGLVLQRGLAPEWNFYIFGSVAVV-GLMLTVLTLLYR 470