BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.1098.p (437 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value Cj0339 [GEPR] COG0477 Permeases of the major facilitator superfa... 252 1e-66 shiA [GEPR] COG0477 Permeases of the major facilitator superfami... 235 1e-61 ECs2778 [GEPR] COG0477 Permeases of the major facilitator superf... 235 1e-61 ZshiA [GEPR] COG0477 Permeases of the major facilitator superfam... 233 5e-61 Cgl2854 [GEPR] COG0477 Permeases of the major facilitator superf... 233 1e-60 >Cj0339 [GEPR] COG0477 Permeases of the major facilitator superfamily Cje Campylobacter jejuni Length = 453 Score = 252 bits (644), Expect = 1e-66, Method: Compositional matrix adjust. Identities = 140/399 (35%), Positives = 227/399 (56%), Gaps = 10/399 (2%) Query: 10 TSTQSKKRLRKVAAATIVGSMLEWYDFYLYATMASIVFSKIFFDVSEPATASLQAFATFA 69 + + +K +K + +G+ +E+ DF LY A+ +FS++FF P A L +F T+ Sbjct: 15 NTPEGRKVFKKAVFSCWLGTAMEYADFALYGLAAATIFSEVFFPEQTPVIALLLSFVTYG 74 Query: 70 IGFVARPIGGLFFGYFGDRYGRKRMLFVTFCMMGLCTTAIGLLPSYAVIGVWSPLCLVLI 129 IGF+ARPIG LFFG+ GD++GRK ++ T +MG+ TT IG +PSYAVIGVW+P+CLV + Sbjct: 75 IGFIARPIGALFFGHLGDKHGRKNVMMATIALMGISTTLIGFIPSYAVIGVWAPICLVAL 134 Query: 130 RIVQGLGAGAELAGAAVTSYEHAAENKKGRQGAWPALGLNLGLLLSSLTVYLLTVNGEQF 189 R +QG GAGAEL+G V E+A ++G + ALG N G LL+S L+ E Sbjct: 135 RFMQGFGAGAELSGGTVMLAEYAPSKRRGLVSSVIALGSNSGTLLASFVWLLMVQMDEAS 194 Query: 190 LLAGGWRIPFLLSFFLVLIGLWVRRSLPETPAYQHAG--------ETHRH-KRPFRELWN 240 GWR+PF+ S + L +++R + ETP ++ +H K+ R W Sbjct: 195 FKEWGWRVPFMGSILIALFAVYIRFHVKETPVFEKQKNEMMKLRLNNEKHMKKDERSFWQ 254 Query: 241 TNVKGLAVVFFVAVGYNALSYIFKTFSLAYLTQFKGISASVTSLSVTLASLVAIFSVPLF 300 + + + + +G N SY+ + F + Y+T+ + SV + +V +ASLV +PL Sbjct: 255 RS-RAFWTMVGLRIGENGPSYLAQGFIVGYVTKILLLDKSVATTAVMIASLVGFLVIPLA 313 Query: 301 GYLCDRFSSKKVLIAGGVLSGLFAYPFMHLLATGDNVHIYLALIIGTGVLAPMMFAPQGS 360 GYL D+F +L ++A+P LL + + + + L +I+G + + +F Q + Sbjct: 314 GYLSDKFGRCITYRMFCLLLMIYAFPAFMLLDSKNEIIVILTIIVGMSLASLGIFGVQAA 373 Query: 361 FLSRQFTVQSRSTGVGSAREIGTALAGGIAPLWALSLVA 399 + F V++R T + A+E+G+ L+GG AP+ A +L+A Sbjct: 374 WGVELFGVKNRYTKMAFAKELGSILSGGTAPMVASALLA 412 >shiA [GEPR] COG0477 Permeases of the major facilitator superfamily Eco Escherichia coli K12 Length = 438 Score = 235 bits (600), Expect = 1e-61, Method: Compositional matrix adjust. Identities = 141/395 (35%), Positives = 210/395 (53%), Gaps = 6/395 (1%) Query: 9 ETSTQSKKRLRKVAAATIVGSMLEWYDFYLYATMASIVFSKIFFDVSEPATASLQAFATF 68 + T S R R+ A + G++++WYDF LY A++VF++ FF PA +L AFATF Sbjct: 11 DEGTLSLSRARRAALGSFAGAVVDWYDFLLYGITAALVFNREFFPQVSPAMGTLAAFATF 70 Query: 69 AIGFVARPIGGLFFGYFGDRYGRKRMLFVTFCMMGLCTTAIGLLPSYAVIGVWSPLCLVL 128 +GF+ RP+GG+ FG+FGDR GRKRML +T MMG+ T IG+LPS++ IG W+P+ LV Sbjct: 71 GVGFLFRPLGGVIFGHFGDRLGRKRMLMLTVWMMGIATALIGILPSFSTIGWWAPILLVT 130 Query: 129 IRIVQGLGAGAELAGAAVTSYEHAAENKKGRQGAWPALGLNLGLLLSSLTVYLLTV--NG 186 +R +QG G E GAA+ S E A +NKK + +G +GLLLS+ V L+++ Sbjct: 131 LRAIQGFAVGGEWGGAALLSVESAPKNKKAFYSSGVQVGYGVGLLLSTGLVSLISMMTTD 190 Query: 187 EQFLLAGGWRIPFLLSFFLVLIGLWVRRSLPETPAY---QHAGETHRHKRPFRELWNTNV 243 EQF L+ GWRIPFL S LVL LWVR + E+ + QH + + P E + Sbjct: 191 EQF-LSWGWRIPFLFSIVLVLGALWVRNGMEESAEFEQQQHYQAAAKKRIPVIEALLRHP 249 Query: 244 KGLAVVFFVAVGYNALSYIFKTFSLAYLTQFKGISASVTSLSVTLASLVAIFSVPLFGYL 303 + + + YI F+L Y TQ G+ + L ++ ++P F +L Sbjct: 250 GAFLKIIALRLCELLTMYIVTAFALNYSTQNMGLPRELFLNIGLLVGGLSCLTIPCFAWL 309 Query: 304 CDRFSSKKVLIAGGVLSGLFAYPFMHLLATGDNVHIYLALIIGTGVLAPMMFAPQGSFLS 363 DRF ++V I G ++ L A+PF L I I+ + M+ Q + Sbjct: 310 ADRFGRRRVYITGTLIGTLSAFPFFMALEAQSIFWIVFFSIMLANIAHDMVVCVQQPMFT 369 Query: 364 RQFTVQSRSTGVGSAREIGTALAGGIAPLWALSLV 398 F R +G G ++ + + GG P A +L+ Sbjct: 370 EMFGASYRYSGAGVGYQVASVVGGGFTPFIAAALI 404 >ECs2778 [GEPR] COG0477 Permeases of the major facilitator superfamily Ecs Escherichia coli O157:H7 Length = 438 Score = 235 bits (600), Expect = 1e-61, Method: Compositional matrix adjust. Identities = 141/399 (35%), Positives = 213/399 (53%), Gaps = 8/399 (2%) Query: 5 KPEHETSTQSKKRLRKVAAATIVGSMLEWYDFYLYATMASIVFSKIFFDVSEPATASLQA 64 +P+ T + S R R+ A + G++++WYDF LY A++VF++ FF PA +L A Sbjct: 9 RPDERTVSLS--RARRAALGSFAGAVVDWYDFLLYGITAALVFNREFFPQVSPAMGTLAA 66 Query: 65 FATFAIGFVARPIGGLFFGYFGDRYGRKRMLFVTFCMMGLCTTAIGLLPSYAVIGVWSPL 124 FATF +GF+ RP+GG+ FG+FGDR GRKRML +T MMG+ T IG+LPS++ IG W+P+ Sbjct: 67 FATFGVGFLFRPLGGVIFGHFGDRLGRKRMLMLTVWMMGIATALIGILPSFSTIGWWAPI 126 Query: 125 CLVLIRIVQGLGAGAELAGAAVTSYEHAAENKKGRQGAWPALGLNLGLLLSSLTVYLLTV 184 LV +R +QG G E GAA+ S E A +NKK + +G +GLLLS+ V L+++ Sbjct: 127 LLVTLRAIQGFAVGGEWGGAALLSVESAPKNKKAFYSSGVQVGYGVGLLLSTGLVSLISM 186 Query: 185 --NGEQFLLAGGWRIPFLLSFFLVLIGLWVRRSLPETPAY---QHAGETHRHKRPFRELW 239 EQF L+ GWRIPFL S LVL LWVR + E+ + Q+ + + P E Sbjct: 187 MTTDEQF-LSWGWRIPFLFSIVLVLGALWVRNGMEESAEFEQQQYNQAAAKKRIPVIEAL 245 Query: 240 NTNVKGLAVVFFVAVGYNALSYIFKTFSLAYLTQFKGISASVTSLSVTLASLVAIFSVPL 299 + + + + YI F+L Y TQ G+ + L ++ ++P Sbjct: 246 LRHPGAFLKIIALRLCELLTMYIVTAFALNYSTQNMGLPRELFLNIGLLVGGLSCLTIPC 305 Query: 300 FGYLCDRFSSKKVLIAGGVLSGLFAYPFMHLLATGDNVHIYLALIIGTGVLAPMMFAPQG 359 F +L DRF ++V I G ++ L A+PF L I I+ + M+ Q Sbjct: 306 FAWLADRFGRRRVYITGALIGTLSAFPFFMALEAQSIFWIVFFSIMLANIAHDMVVCVQQ 365 Query: 360 SFLSRQFTVQSRSTGVGSAREIGTALAGGIAPLWALSLV 398 + F R +G G ++ + + GG P A +L+ Sbjct: 366 PMFTEMFGASYRYSGAGVGYQVASVVGGGFTPFIAAALI 404 >ZshiA [GEPR] COG0477 Permeases of the major facilitator superfamily EcZ Escherichia coli O157:H7 EDL933 Length = 438 Score = 233 bits (595), Expect = 5e-61, Method: Compositional matrix adjust. Identities = 140/399 (35%), Positives = 212/399 (53%), Gaps = 8/399 (2%) Query: 5 KPEHETSTQSKKRLRKVAAATIVGSMLEWYDFYLYATMASIVFSKIFFDVSEPATASLQA 64 +P+ T + S R R+ A + G++++WYDF LY A++VF++ FF PA +L A Sbjct: 9 RPDERTVSLS--RARRAALGSFAGAVVDWYDFLLYGITAALVFNREFFPQVSPAMGTLAA 66 Query: 65 FATFAIGFVARPIGGLFFGYFGDRYGRKRMLFVTFCMMGLCTTAIGLLPSYAVIGVWSPL 124 FATF +GF+ RP+GG+ FG+FGDR GRKRML +T MMG+ T IG+LPS++ IG W+P+ Sbjct: 67 FATFGVGFLFRPLGGVIFGHFGDRLGRKRMLMLTVWMMGIATALIGILPSFSTIGWWAPI 126 Query: 125 CLVLIRIVQGLGAGAELAGAAVTSYEHAAENKKGRQGAWPALGLNLGLLLSSLTVYLLTV 184 LV +R +QG G E GAA+ S E A +NKK + +G +GLLLS+ V L+++ Sbjct: 127 LLVTLRAIQGFAVGGEWGGAALLSVESAPKNKKAFYSSGVQVGYGVGLLLSTGLVSLISM 186 Query: 185 --NGEQFLLAGGWRIPFLLSFFLVLIGLWVRRSLPETPAY---QHAGETHRHKRPFRELW 239 EQF L+ GWRIPFL S LVL LWVR + E+ + Q+ + + P E Sbjct: 187 MTTDEQF-LSWGWRIPFLFSIVLVLGALWVRNGMEESAEFEQQQYNQAAAKKRIPVIEAL 245 Query: 240 NTNVKGLAVVFFVAVGYNALSYIFKTFSLAYLTQFKGISASVTSLSVTLASLVAIFSVPL 299 + + + + YI F+L Y TQ G+ + L ++ ++P Sbjct: 246 LRHPGAFLKIIALRLCELLTMYIVTAFALNYSTQNMGLPRELFLNIGLLVGGLSCLTIPC 305 Query: 300 FGYLCDRFSSKKVLIAGGVLSGLFAYPFMHLLATGDNVHIYLALIIGTGVLAPMMFAPQG 359 F + DRF ++V I G ++ L A+PF L I I+ + M+ Q Sbjct: 306 FAWXADRFGRRRVYITGALIGTLSAFPFFMALEAQSIFWIVFFSIMLANIAHDMVVCVQQ 365 Query: 360 SFLSRQFTVQSRSTGVGSAREIGTALAGGIAPLWALSLV 398 + F R +G G ++ + + GG P A +L+ Sbjct: 366 PMFTEMFGASYRYSGAGVGYQVASVVXGGFTPFIAAALI 404 >Cgl2854 [GEPR] COG0477 Permeases of the major facilitator superfamily Cgl Corynebacterium glutamicum Length = 433 Score = 233 bits (593), Expect = 1e-60, Method: Compositional matrix adjust. Identities = 148/422 (35%), Positives = 241/422 (57%), Gaps = 2/422 (0%) Query: 8 HETSTQSKKRLRKVAAATIVGSMLEWYDFYLYATMASIVFSKIFFDVSEPATASLQAFAT 67 + S ++ ++V ++ GS++EW+DF +Y T+A++VF+K++F +++ A+A+ Sbjct: 6 DQNSPPKQQLNKRVLLGSLSGSVIEWFDFLVYGTVAALVFNKMYFPSGNEFLSTILAYAS 65 Query: 68 FAIGFVARPIGGLFFGYFGDRYGRKRMLFVTFCMMGLCTTAIGLLPSYAVIGVWSPLCLV 127 F++ F RPIGG+ F + GDR GRK+ LF+T +MG T AIGLLP Y IG+W+P+ L+ Sbjct: 66 FSLTFFFRPIGGVIFAHIGDRIGRKKTLFITLMLMGGGTVAIGLLPDYNAIGIWAPILLM 125 Query: 128 LIRIVQGLGAGAELAGAAVTSYEHAAENKKGRQGAWPALGLNLGLLLSSLTVYLLTVNGE 187 +RI+QG+G G E GA + +YE+A + ++G GA P +G++LG+LL++ + LLT+ E Sbjct: 126 FLRILQGIGIGGEWGGALLLAYEYAPKKQRGLYGAVPQMGISLGMLLAAGVISLLTLMPE 185 Query: 188 QFLLAGGWRIPFLLSFFLVLIGLWVRRSLPETPAYQHAGETHRH-KRPFRELWNTNVKGL 246 L GWRIPF+ S LV IGL++R L ETP ++ ++ + K P +E+ + Sbjct: 186 DQFLTWGWRIPFVGSILLVFIGLFIRNGLDETPEFKRIRDSGQQVKMPLKEVLTKYWPAV 245 Query: 247 AVVFFVAVGYNALSYIFKTFSLAYLTQFKGISASVTSLSVTLASLVAIFSVPLFGYLCDR 306 V YIF T+ +AY T F I ++ L+V A+LVA +PLFG DR Sbjct: 246 LVSIGAKAAETGPFYIFGTYIVAYATNFLNIRDNIVLLAVACAALVATIWMPLFGSFSDR 305 Query: 307 FSSKKVLIAGGVLSGLFAYPFMHLLATGDNVHIYLALIIGTGVLAPMMFAPQGSFLSRQF 366 + + + + P+ +L TG+ +++ +IG G+L + A G+ ++ F Sbjct: 306 VNRAVLYRICASATIVLIVPYYLVLNTGEIWALFITTVIGFGILWGSVNAILGTVIAENF 365 Query: 367 TVQSRSTGVGSAREIGTALAGGIAPLWALSLVARSAVHDTNGVALILACAGILVAFAAFF 426 + R TG ++G AL GG AP+ A L S +A+ +A +L A+FF Sbjct: 366 APEVRYTGATLGYQVGAALFGGTAPIIAAWLFEISG-GQWWPIAVYVAACCLLSVIASFF 424 Query: 427 DQ 428 Q Sbjct: 425 IQ 426