BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.0881.p (440 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PA5362 [R] COG1253 Hemolysins and related proteins containing CB... 392 e-109 CAC1422 [R] COG1253 Hemolysins and related proteins containing C... 262 1e-69 BS_yhdT [R] COG1253 Hemolysins and related proteins containing C... 261 2e-69 lin2334 [R] COG1253 Hemolysins and related proteins containing C... 260 5e-69 Cj0183 [R] COG1253 Hemolysins and related proteins containing CB... 256 5e-68 >PA5362 [R] COG1253 Hemolysins and related proteins containing CBS domains Pae Pseudomonas aeruginosa Length = 446 Score = 392 bits (1008), Expect = e-109, Method: Compositional matrix adjust. Identities = 210/430 (48%), Positives = 287/430 (66%), Gaps = 9/430 (2%) Query: 6 LIVAAFFLVALNGFFVAAEFSLVKLRQTRIRAIAKTQGLRGRILAVVHNQLDAYLSACQL 65 LI+ A FLV LNGFFVAAEF++VKLR TR+ IAK G RG IL VHNQLDAYLSACQL Sbjct: 18 LILFALFLVLLNGFFVAAEFAMVKLRATRVETIAKQHGWRGTILRKVHNQLDAYLSACQL 77 Query: 66 GITLASLGLGWIGEPAFARLLEPIFTLLGVSNQELIHGISFVFAFLVISFLHIVAGELAP 125 GITLASLGLGW+GEPAFA LLEP+ ++GV + ELI GISF AF +IS+LHIV GELAP Sbjct: 78 GITLASLGLGWVGEPAFAELLEPLLAMIGVHSDELIRGISFFTAFFIISYLHIVVGELAP 137 Query: 126 KSMAIRSPEKLGLWCAVPLYGFYWGMYPLIWVLNASSNWLLRVAGLG-AAHGHDAHYSSD 184 KS AIR PE L LW AVPLY FYW MYP IW+LNAS+N +L++AG G H+ HYS D Sbjct: 138 KSWAIRKPELLSLWTAVPLYLFYWLMYPAIWLLNASANAILKIAGQGEPGPHHEHHYSRD 197 Query: 185 ELKLILRAGGKSGKSGKFTRDEWNVLVQSLNFAELDVADIMRPASEIVALGDDKSLEENL 244 ELKLIL + S + R VL ++ EL+V D ++V L D L + L Sbjct: 198 ELKLILHSSRAQDPSDQGMR----VLASAVELGELEVVDWANSREDLVYLEHDAPLADIL 253 Query: 245 DIIYRNRYSRYPYFDAERQQVLGLVHLKDVFLAQQDGRAIS---NLKDYLRPVQFISPAL 301 +I R++YSRYP +D+ + + +GL+H+KD+ LA ++ +L + +RP++ ++ Sbjct: 254 AVIRRHKYSRYPVWDSHKGEFIGLLHIKDLLLALSALDSLPETFDLDELVRPLEIVTKHT 313 Query: 302 PALDLLRRFRTGMPHFAIIGKKGQSPLGFITLDNMLSLLVGEIRDEFRHNTGEWSRQDDG 361 P LL +FR G HFA++ + +GF+T++++L +LVG+I+DE R G Sbjct: 314 PLSRLLEQFRKGGAHFAVVEEADHKVVGFLTMEDVLEVLVGDIQDEHRKTERGILAYQPG 373 Query: 362 TLLGKGSLPIVTLENMLGIDIDYDDSIDSVGGLVMEKLGDLPKEGQKIEFAAFDVVIKRM 421 LL +G P+ LE +LGID+D+ ++ D++ GLV + L +P+E + ++ +++K+M Sbjct: 374 KLLVRGDTPLFKLERLLGIDLDHVEA-DTLAGLVYDTLKRVPEEEEVLDTEGLRIIVKKM 432 Query: 422 SGPKIVLVKV 431 GPKIVL KV Sbjct: 433 RGPKIVLAKV 442 >CAC1422 [R] COG1253 Hemolysins and related proteins containing CBS domains Cac Clostridium acetobutylicum Length = 428 Score = 262 bits (670), Expect = 1e-69, Method: Compositional matrix adjust. Identities = 137/420 (32%), Positives = 247/420 (58%), Gaps = 14/420 (3%) Query: 16 LNGFFVAAEFSLVKLRQTRIRAIAKTQGLRGRILAVVHNQLDAYLSACQLGITLASLGLG 75 +N FFVAAEFS+VK+R++RI + + V N L++YLSACQLGITLASLGLG Sbjct: 16 MNAFFVAAEFSMVKIRKSRIETLVLDGDKNAKYALGVINNLNSYLSACQLGITLASLGLG 75 Query: 76 WIGEPAFARLLEPIFTLLGVSNQELIHGISFVFAFLVISFLHIVAGELAPKSMAIRSPEK 135 W+GEPA +++L P+F LL + Q +I IS V F++I+ HIV GELAPKS+AI + E Sbjct: 76 WVGEPAVSKMLSPLFNLLKIPKQ-IIGSISVVVGFIIITGFHIVLGELAPKSVAILNTES 134 Query: 136 LGLWCAVPLYGFYWGMYPLIWVLNASSNWLLRVAGLGAAHGHDAHYSSDELKLILRAGGK 195 + A+PL FY YP+I N S++ +L++ G+ H+ ++ +E+++++ + Sbjct: 135 IAKATAIPLTLFYKFTYPIIVAFNKSTDLVLKLFGIKQVDEHEEAHTDEEIRMLVE---E 191 Query: 196 SGKSGKFTRDEWNVLVQSLNFAELDVADIMRPASEIVALGDDKSLEENLDIIYRNRYSRY 255 S K G + E + +F+E V +IM P +++ + + S ++ + + ++RY Sbjct: 192 SYKHGLIDKTELTFVDNVFDFSEKTVKEIMVPRTDMKCIFVEDSFDDIVGVTIDEHFTRY 251 Query: 256 PYFDAERQQVLGLVHLKDVF---LAQQDGRAISNLKDYLRPVQFISPALPALDLLRRFRT 312 P + + ++GL+H+KD++ + ++D + ++ +R ++F+ ++ +L R F+ Sbjct: 252 PVCEESKDNIIGLIHIKDLYKLKINKEDEK----IESIIREIKFVPESMSISELFRMFQK 307 Query: 313 GMPHFAIIGKKGQSPLGFITLDNMLSLLVGEIRDEFRHNTGEWSRQDDGTLLGKGSLPIV 372 AI+ + G +T++++L +VGEI+DEF E + ++G+ + G + I Sbjct: 308 ERMQMAIVIDEYGGTFGLVTIEDILEEIVGEIQDEFDEEMEEIIKTENGSYVVDGKVLIE 367 Query: 373 TLENMLGIDIDYDDSIDSVGGLVMEKLGDLPKEGQKIEFAAFDVVIKRMSGPKI--VLVK 430 + +L I+I Y+++ID++GG + KL PK +KI + + +I + +I +L+K Sbjct: 368 DINELLDIEI-YEENIDTIGGWIYSKLKKYPKTNEKINYGNYQFIILKCDRRRIEKILIK 426 >BS_yhdT [R] COG1253 Hemolysins and related proteins containing CBS domains Bsu Bacillus subtilis Length = 461 Score = 261 bits (668), Expect = 2e-69, Method: Compositional matrix adjust. Identities = 153/430 (35%), Positives = 253/430 (58%), Gaps = 14/430 (3%) Query: 13 LVALNGFFVAAEFSLVKLRQTRIRAIAKTQGLRGRILAV-VHNQLDAYLSACQLGITLAS 71 L+AL FFVA+EF++V++R++RI + T+G + ILA V LD YLSA QLGITL S Sbjct: 13 LIALTAFFVASEFAIVRVRRSRIDQLI-TEGNKRAILARRVITDLDEYLSASQLGITLTS 71 Query: 72 LGLGWIGEPAFARLLEPIFTLLGVSNQELIHGISFVFAFLVISFLHIVAGELAPKSMAIR 131 +GLG +GEPAF RLL P+F LG+ + + H +SF A+ +I+FLH+V GELAPK++AI+ Sbjct: 72 IGLGVLGEPAFERLLHPLFEPLGLPDS-VSHAVSFAVAYGLITFLHVVVGELAPKTVAIQ 130 Query: 132 SPEKLGLWCAVPLYGFYWGMYPLIWVLNASSNWLLRVAGLGAAHGHDAHYSSDELKLILR 191 E+L L A PL FY ++P IW+LN S+ L + GL A HD +S +EL+++L Sbjct: 131 KAEQLTLLIAGPLRLFYLLLFPFIWILNGSARLLCGMFGLKPASEHDGSHSEEELRMLL- 189 Query: 192 AGGKSGKSGKFTRDEWNVLVQSLNFAELDVADIMRPASEIVALGDDKSLEENLDIIYRNR 251 +S K+G+ E+ + + F +IM P E+ A+ + ++ E L+++ + + Sbjct: 190 --SESLKNGEINPSEYKYVNKIFEFDNRIAKEIMIPRKEMAAVSTEMTMAEMLEVMLKEK 247 Query: 252 YSRYPYFDAERQQVLGLVHLK----DVFLAQQDGRAISNLKDYLRPVQFISPALPALDLL 307 Y+R+P D ++ VLGLV+ K D+ ++ R + Y+RPV + +P DLL Sbjct: 248 YTRWPVTDGDKDSVLGLVNTKHLFSDLLFMTEEERMKMTIHPYVRPVIEVIETIPVHDLL 307 Query: 308 RRFRTGMPHFAIIGKKGQSPLGFITLDNMLSLLVGEIRDEFRHNTGEWSRQ-DDGTLLGK 366 + + H AI+ + G +T +++L +VGEIRDEF + ++ DG + Sbjct: 308 IKMQRERIHMAILSDEYGGTSGLVTTEDILEEIVGEIRDEFDEDEQPLIQKLGDGHYVMD 367 Query: 367 GSLPIVTLENMLGIDIDYDDSIDSVGGLVMEKLGDLPKEGQKIEFAAFDVVIKRMSGPKI 426 G + I + ++LG I D +D++GGL++++ D+ + G+ I ++ + + +M G I Sbjct: 368 GKVRIDQVNSLLGASIQED--VDTIGGLILKENIDI-EAGESIRIGSYTIKVLKMDGRLI 424 Query: 427 VLVKVYPKVG 436 + + + G Sbjct: 425 KQIDIKEEAG 434 >lin2334 [R] COG1253 Hemolysins and related proteins containing CBS domains Lin Listeria innocua Length = 434 Score = 260 bits (664), Expect = 5e-69, Method: Compositional matrix adjust. Identities = 148/436 (33%), Positives = 256/436 (58%), Gaps = 11/436 (2%) Query: 5 LLIVAAFFLVALNGFFVAAEFSLVKLRQTRIRAIAKTQGLRGRILAVVHNQLDAYLSACQ 64 LI+A L+A++ FFVA EF++VK+R +R+ + + R + ++N L+AYLSACQ Sbjct: 7 FLIIA--LLIAISAFFVATEFAIVKMRPSRLDQLIAEKDKRAVLARHIYNHLNAYLSACQ 64 Query: 65 LGITLASLGLGWIGEPAFARLLEPIFTLLGVSNQELIHGISFVFAFLVISFLHIVAGELA 124 LGIT++SLGLGW+GE L P+F+LL + Q I +SF AFL I+FLH+V GEL Sbjct: 65 LGITISSLGLGWLGESTVEAALHPLFSLLELP-QSAITILSFTIAFLFITFLHVVVGELV 123 Query: 125 PKSMAIRSPEKLGLWCAVPLYGFYWGMYPLIWVLNASSNWLLRVAGLGAAHGHDAHYSSD 184 PK++AI E + L A PL+ FY M+P IW+LN S+ ++ R+ GL A H+ ++ D Sbjct: 124 PKTLAIDKTETVALAVARPLHIFYKVMFPFIWILNGSAVFIARLFGLEPASEHEIAHTED 183 Query: 185 ELKLILRAGGKSGKSGKFTRDEWNVLVQSLNFAELDVADIMRPASEIVALGDDKSLEENL 244 ELK+I+ G+S KSG+ + E+ + + +F E ++M P +EIV + ++ E Sbjct: 184 ELKIIV---GESYKSGEINQSEFRYVNKIFDFDERMAKEVMIPRTEIVTVDTGSTIGELS 240 Query: 245 DIIYRNRYSRYPYFDAERQQVLGLVHLKDVFLA--QQDGRAISNLKDYLRPVQFISPALP 302 DI+ RY+RYP D ++ V+G+++LK++ A + ++ Y++P+ + +P Sbjct: 241 DIMQNERYTRYPVIDGDKDHVIGVLNLKEILSAYVEHGSNPSFSIDPYVKPIIRVIETIP 300 Query: 303 ALDLLRRFRTGMPHFAIIGKKGQSPLGFITLDNMLSLLVGEIRDEFRHNT-GEWSRQDDG 361 +LL R + H AI+ + G +T+++++ +VG+IRDEF + E + DG Sbjct: 301 IKELLFRMQRERSHIAILLDEYGGTSGLVTVEDIVEEIVGDIRDEFDADEIPEIRKIKDG 360 Query: 362 TLLGKGSLPIVTLENMLGIDIDYDDSIDSVGGLVMEKLGDLPKEGQKIEFAAFDVVIKRM 421 + L I + N+LG +I+ ++ +D++GG + + ++ + G +I++ F +K+ Sbjct: 361 HYIVDAKLLIDEVNNILGTEIE-EEEVDTIGGWFLTQNYEV-EVGDEIDYDGFIFRVKQG 418 Query: 422 SGPKIVLVKVYPKVGE 437 I +++ K + Sbjct: 419 EPHHIEYIEIIKKTND 434 >Cj0183 [R] COG1253 Hemolysins and related proteins containing CBS domains Cje Campylobacter jejuni Length = 452 Score = 256 bits (655), Expect = 5e-68, Method: Compositional matrix adjust. Identities = 146/438 (33%), Positives = 247/438 (56%), Gaps = 7/438 (1%) Query: 3 NILLIVAAFFLVALNGFFVAAEFSLVKLRQTRIRAIAKTQGLRGRILAVVHNQLDAYLSA 62 +IL++V A LV LNGFFV +EFS+VK+R++++ + K + + V ++LD YLSA Sbjct: 22 SILMVVVALALVFLNGFFVLSEFSIVKVRRSKLEEMVKEKKAGAKKALEVTSRLDTYLSA 81 Query: 63 CQLGITLASLGLGWIGEPAFARLLEPIFTLLGVSNQELIHGISFVFAFLVISFLHIVAGE 122 CQLGITL+SL LGWIGEPA A++LE LG S +IH ++F+ AF +I+ LH+V GE Sbjct: 82 CQLGITLSSLALGWIGEPAIAKMLEIPLINLGFSTV-IIHTMAFIIAFSIITLLHVVLGE 140 Query: 123 LAPKSMAIRSPEKLGLWCAVPLYGFYWGMYPLIWVLNASSNWLLRVAGLGAAHGHDAHYS 182 L PKS+AI +K L+ A PL+ F+ P I + + + L++ G+ A + +S Sbjct: 141 LVPKSIAIAVADKAVLFIARPLHWFWMLFLPCIKIFDFLAAISLKLFGIKPAKESELTHS 200 Query: 183 SDELKLILRAGGKSGKSGKFTRDEWNVLVQSLNFAELDVADIMRPASEIVALGDDKSLEE 242 +E+K+I +S K G E ++ +++F++ +IM P +++ L KS EE Sbjct: 201 EEEIKII---ASESQKGGVLDEFETEIIRNAVDFSDTVAKEIMTPRKDMICLNKQKSYEE 257 Query: 243 NLDIIYRNRYSRYPYFDAERQQVLGLVHLKDVFLAQQDGRAISNLKDYLRPVQFISPALP 302 N+ II ++++R+PY D + +LG++H++D+ + + ++ NL +++P+ + + Sbjct: 258 NMQIICEHKHTRFPYIDGSKDTILGMIHIRDIIQNELNHKS-QNLDTFVKPLILVPENIS 316 Query: 303 ALDLLRRFRTGMPHFAIIGKKGQSPLGFITLDNMLSLLVGEIRDEFRHNTGEWSRQDDGT 362 +L H A++ + G +T+++++ ++GEI+ E H + + + Sbjct: 317 ISKVLVMMNKERSHTALVVDEYGGTAGILTMEDIMEEIIGEIKSE--HEEDSYKKLAENI 374 Query: 363 LLGKGSLPIVTLENMLGIDIDYDDSIDSVGGLVMEKLGDLPKEGQKIEFAAFDVVIKRMS 422 +G I T+E ML I+ D D ++GG V LG LP G +IE +K+M Sbjct: 375 YEFQGRCDIETVEEMLVINYDEDLEQVTIGGYVFNLLGRLPMVGDRIEDELCYYEVKKMD 434 Query: 423 GPKIVLVKVYPKVGEVRE 440 G I VKV K + E Sbjct: 435 GNSIERVKVVKKTNKDEE 452