BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.0872.p (485 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PA0265 [C] COG1012 NAD-dependent aldehyde dehydrogenases Pae Pse... 725 0.0 gabD [C] COG1012 NAD-dependent aldehyde dehydrogenases Eco Esche... 708 0.0 ZgabD [C] COG1012 NAD-dependent aldehyde dehydrogenases EcZ Esch... 704 0.0 ECs3522 [C] COG1012 NAD-dependent aldehyde dehydrogenases Ecs Es... 704 0.0 STM2791 [C] COG1012 NAD-dependent aldehyde dehydrogenases Sty Sa... 702 0.0 >PA0265 [C] COG1012 NAD-dependent aldehyde dehydrogenases Pae Pseudomonas aeruginosa Length = 483 Score = 725 bits (1871), Expect = 0.0, Method: Compositional matrix adjust. Identities = 343/482 (71%), Positives = 407/482 (84%) Query: 4 QLKDPSLLRQQAYLNGAWCDADSGAKLEVHNPANGQLLGHVPLMGATETRRAIDAANAAW 63 QLKD L RQQAY++GAW DAD+G ++V+NPA G+++G VP MGA ETRRAI+AA+ A Sbjct: 2 QLKDAKLFRQQAYVDGAWVDADNGQTIKVNNPATGEIIGSVPKMGAAETRRAIEAADKAL 61 Query: 64 PAWKKKTAKERSALLRRWYELMLANADDLALIMTAEQGKPLAEARGEIGYAASFIEWFAE 123 PAW+ TAKER+ LRRW++LM+ N DDLA +MT EQGKPLAEA+GEI YAASF+EWF E Sbjct: 62 PAWRALTAKERANKLRRWFDLMIENQDDLARLMTIEQGKPLAEAKGEIAYAASFLEWFGE 121 Query: 124 EGKRTYGDTIPSPSPTNRIVVIKEAIGVCAAITPWNFPAAMITRKAGPALAAGCPMVLKP 183 E KR YGDTIP P RI+VIK+ IGV AAITPWNFP+AMITRKAGPALAAGC MVLKP Sbjct: 122 EAKRIYGDTIPGHQPDKRIIVIKQPIGVTAAITPWNFPSAMITRKAGPALAAGCTMVLKP 181 Query: 184 AEATPFSALALAVLAERAGIPAGVFSVVTGTPKEIGGEMTSNPIVRKISFTGSTGVGKLL 243 A TP+SALALA LAERAGIP GVFSVVTG+ E+GGE+TSNPIVRK++FTGST +G+ L Sbjct: 182 ASQTPYSALALAELAERAGIPKGVFSVVTGSAGEVGGELTSNPIVRKLTFTGSTEIGRQL 241 Query: 244 MQQSASSIKKLSLELGGNAPFIVFDDADLDAAVEGAIASKYRNAGQTCVCANRIYVQDGV 303 M + A IKK+SLELGGNAPFIVFDDADLDAAVEGA+ SKYRN GQTCVCANR+YVQDGV Sbjct: 242 MAECAQDIKKVSLELGGNAPFIVFDDADLDAAVEGALISKYRNNGQTCVCANRLYVQDGV 301 Query: 304 YDAFAAKLVEAVKKLKVGDGMENGVTQGPLINEQAVKKVEQHVADALAKGARVLLGGKRH 363 YDAF KL AV KL +G+G+E GVT GPLI+ +AV KVE+H+ADA++KGA+V+ GGK H Sbjct: 302 YDAFVDKLKAAVAKLNIGNGLEAGVTTGPLIDAKAVAKVEEHIADAVSKGAKVVSGGKPH 361 Query: 364 ALGHGFFEPTVLADVTPAMQVAREETFGPMAPLFRFKTDDEALSLANDTEFGLASYFYSR 423 ALG FFEPT+L DV V+++ETFGP+AP+FRFK + E ++++NDTEFGLASYFY+R Sbjct: 362 ALGGTFFEPTILVDVPKNALVSKDETFGPLAPVFRFKDEAEVIAMSNDTEFGLASYFYAR 421 Query: 424 DIGRIWRVAEGLESGMVGINTGLISNEVAPFGGVKQSGLGREGSHYGIDDYLVVKYLCMG 483 D+ R++RVAE LE GMVGINTGLISNEVAPFGG+K SGLGREGS YGI+DYL +KYLC+G Sbjct: 422 DLARVFRVAEQLEYGMVGINTGLISNEVAPFGGIKASGLGREGSKYGIEDYLEIKYLCLG 481 Query: 484 GI 485 GI Sbjct: 482 GI 483 >gabD [C] COG1012 NAD-dependent aldehyde dehydrogenases Eco Escherichia coli K12 Length = 482 Score = 708 bits (1827), Expect = 0.0, Method: Compositional matrix adjust. Identities = 336/480 (70%), Positives = 399/480 (83%) Query: 4 QLKDPSLLRQQAYLNGAWCDADSGAKLEVHNPANGQLLGHVPLMGATETRRAIDAANAAW 63 +L D +L RQQA +NG W DA++G ++V NPANG LG VP MGA ETR AIDAAN A Sbjct: 2 KLNDSNLFRQQALINGEWLDANNGEAIDVTNPANGDKLGSVPKMGADETRAAIDAANRAL 61 Query: 64 PAWKKKTAKERSALLRRWYELMLANADDLALIMTAEQGKPLAEARGEIGYAASFIEWFAE 123 PAW+ TAKER+ +LR W+ LM+ + DDLA +MT EQGKPLAEA+GEI YAASFIEWFAE Sbjct: 62 PAWRALTAKERATILRNWFNLMMEHQDDLARLMTLEQGKPLAEAKGEISYAASFIEWFAE 121 Query: 124 EGKRTYGDTIPSPSPTNRIVVIKEAIGVCAAITPWNFPAAMITRKAGPALAAGCPMVLKP 183 EGKR YGDTIP R++VIK+ IGV AAITPWNFPAAMITRKAGPALAAGC MVLKP Sbjct: 122 EGKRIYGDTIPGHQADKRLIVIKQPIGVTAAITPWNFPAAMITRKAGPALAAGCTMVLKP 181 Query: 184 AEATPFSALALAVLAERAGIPAGVFSVVTGTPKEIGGEMTSNPIVRKISFTGSTGVGKLL 243 A TPFSALALA LA RAG+PAGVF+VVTG+ +G E+TSNP+VRK+SFTGST +G+ L Sbjct: 182 ASQTPFSALALAELAIRAGVPAGVFNVVTGSAGAVGNELTSNPLVRKLSFTGSTEIGRQL 241 Query: 244 MQQSASSIKKLSLELGGNAPFIVFDDADLDAAVEGAIASKYRNAGQTCVCANRIYVQDGV 303 M+Q A IKK+SLELGGNAPFIVFDDADLD AVEGA+ASK+RNAGQTCVCANR+YVQDGV Sbjct: 242 MEQCAKDIKKVSLELGGNAPFIVFDDADLDKAVEGALASKFRNAGQTCVCANRLYVQDGV 301 Query: 304 YDAFAAKLVEAVKKLKVGDGMENGVTQGPLINEQAVKKVEQHVADALAKGARVLLGGKRH 363 YD FA KL +AV KL +GDG++NGVT GPLI+E+AV KVE+H+ADAL KGARV+ GGK H Sbjct: 302 YDRFAEKLQQAVSKLHIGDGLDNGVTIGPLIDEKAVAKVEEHIADALEKGARVVCGGKAH 361 Query: 364 ALGHGFFEPTVLADVTPAMQVAREETFGPMAPLFRFKTDDEALSLANDTEFGLASYFYSR 423 G FF+PT+L DV +V++EETFGP+APLFRFK + + ++ ANDTEFGLA+YFY+R Sbjct: 362 ERGGNFFQPTILVDVPANAKVSKEETFGPLAPLFRFKDEADVIAQANDTEFGLAAYFYAR 421 Query: 424 DIGRIWRVAEGLESGMVGINTGLISNEVAPFGGVKQSGLGREGSHYGIDDYLVVKYLCMG 483 D+ R++RV E LE G+VGINTG+ISNEVAPFGG+K SGLGREGS YGI+DYL +KY+C+G Sbjct: 422 DLSRVFRVGEALEYGIVGINTGIISNEVAPFGGIKASGLGREGSKYGIEDYLEIKYMCIG 481 >ZgabD [C] COG1012 NAD-dependent aldehyde dehydrogenases EcZ Escherichia coli O157:H7 EDL933 Length = 482 Score = 704 bits (1817), Expect = 0.0, Method: Compositional matrix adjust. Identities = 335/480 (69%), Positives = 397/480 (82%) Query: 4 QLKDPSLLRQQAYLNGAWCDADSGAKLEVHNPANGQLLGHVPLMGATETRRAIDAANAAW 63 +L D +L RQQA +NG W DA++G ++V NPANG LG VP MGA ETR AIDAAN A Sbjct: 2 KLNDSNLFRQQALINGEWLDANNGEVIDVTNPANGDKLGSVPKMGADETRAAIDAANRAL 61 Query: 64 PAWKKKTAKERSALLRRWYELMLANADDLALIMTAEQGKPLAEARGEIGYAASFIEWFAE 123 P W+ TAKER+ +LR W+ LM+ + DDLA +MT EQGKPLAEA+GEI YAASFIEWFAE Sbjct: 62 PVWRALTAKERANILRNWFNLMMEHQDDLARLMTLEQGKPLAEAKGEISYAASFIEWFAE 121 Query: 124 EGKRTYGDTIPSPSPTNRIVVIKEAIGVCAAITPWNFPAAMITRKAGPALAAGCPMVLKP 183 EGKR YGDTIP R++VIK+ IGV AAITPWNFPAAMITRKAGPALAAGC MVLKP Sbjct: 122 EGKRIYGDTIPGHQADKRLIVIKQPIGVTAAITPWNFPAAMITRKAGPALAAGCTMVLKP 181 Query: 184 AEATPFSALALAVLAERAGIPAGVFSVVTGTPKEIGGEMTSNPIVRKISFTGSTGVGKLL 243 A TPFSALALA LA RAGIPAGVF+VVTG+ +G E+TSNP+VRK+SFTGST +G+ L Sbjct: 182 ASQTPFSALALAELAIRAGIPAGVFNVVTGSAGAVGNELTSNPLVRKLSFTGSTEIGRQL 241 Query: 244 MQQSASSIKKLSLELGGNAPFIVFDDADLDAAVEGAIASKYRNAGQTCVCANRIYVQDGV 303 M+Q A IKK+SLELGGNAPFIVFDDADLD AVEGA+ASK+RNAGQTCVCANR+YVQDGV Sbjct: 242 MEQCAKDIKKVSLELGGNAPFIVFDDADLDKAVEGALASKFRNAGQTCVCANRLYVQDGV 301 Query: 304 YDAFAAKLVEAVKKLKVGDGMENGVTQGPLINEQAVKKVEQHVADALAKGARVLLGGKRH 363 YD FA KL +AV KL +GDG++ GVT GPLI+E+AV KVE+H+ADAL KGARV+ GGK H Sbjct: 302 YDRFAEKLQQAVSKLHIGDGLDKGVTIGPLIDEKAVAKVEEHIADALEKGARVVCGGKAH 361 Query: 364 ALGHGFFEPTVLADVTPAMQVAREETFGPMAPLFRFKTDDEALSLANDTEFGLASYFYSR 423 G FF+PT+L DV +V++EETFGP+APLFRFK + + ++ ANDTEFGLA+YFY+R Sbjct: 362 ERGGNFFQPTILVDVPANAKVSKEETFGPLAPLFRFKDEADVIAQANDTEFGLAAYFYAR 421 Query: 424 DIGRIWRVAEGLESGMVGINTGLISNEVAPFGGVKQSGLGREGSHYGIDDYLVVKYLCMG 483 D+ R++RV E LE G+VGINTG+ISNEVAPFGG+K SGLGREGS YGI+DYL +KY+C+G Sbjct: 422 DLSRVFRVGEALEYGIVGINTGIISNEVAPFGGIKASGLGREGSKYGIEDYLEIKYMCIG 481 >ECs3522 [C] COG1012 NAD-dependent aldehyde dehydrogenases Ecs Escherichia coli O157:H7 Length = 482 Score = 704 bits (1817), Expect = 0.0, Method: Compositional matrix adjust. Identities = 335/480 (69%), Positives = 397/480 (82%) Query: 4 QLKDPSLLRQQAYLNGAWCDADSGAKLEVHNPANGQLLGHVPLMGATETRRAIDAANAAW 63 +L D +L RQQA +NG W DA++G ++V NPANG LG VP MGA ETR AIDAAN A Sbjct: 2 KLNDSNLFRQQALINGEWLDANNGEVIDVTNPANGDKLGSVPKMGADETRAAIDAANRAL 61 Query: 64 PAWKKKTAKERSALLRRWYELMLANADDLALIMTAEQGKPLAEARGEIGYAASFIEWFAE 123 P W+ TAKER+ +LR W+ LM+ + DDLA +MT EQGKPLAEA+GEI YAASFIEWFAE Sbjct: 62 PVWRALTAKERANILRNWFNLMMEHQDDLARLMTLEQGKPLAEAKGEISYAASFIEWFAE 121 Query: 124 EGKRTYGDTIPSPSPTNRIVVIKEAIGVCAAITPWNFPAAMITRKAGPALAAGCPMVLKP 183 EGKR YGDTIP R++VIK+ IGV AAITPWNFPAAMITRKAGPALAAGC MVLKP Sbjct: 122 EGKRIYGDTIPGHQADKRLIVIKQPIGVTAAITPWNFPAAMITRKAGPALAAGCTMVLKP 181 Query: 184 AEATPFSALALAVLAERAGIPAGVFSVVTGTPKEIGGEMTSNPIVRKISFTGSTGVGKLL 243 A TPFSALALA LA RAGIPAGVF+VVTG+ +G E+TSNP+VRK+SFTGST +G+ L Sbjct: 182 ASQTPFSALALAELAIRAGIPAGVFNVVTGSAGAVGNELTSNPLVRKLSFTGSTEIGRQL 241 Query: 244 MQQSASSIKKLSLELGGNAPFIVFDDADLDAAVEGAIASKYRNAGQTCVCANRIYVQDGV 303 M+Q A IKK+SLELGGNAPFIVFDDADLD AVEGA+ASK+RNAGQTCVCANR+YVQDGV Sbjct: 242 MEQCAKDIKKVSLELGGNAPFIVFDDADLDKAVEGALASKFRNAGQTCVCANRLYVQDGV 301 Query: 304 YDAFAAKLVEAVKKLKVGDGMENGVTQGPLINEQAVKKVEQHVADALAKGARVLLGGKRH 363 YD FA KL +AV KL +GDG++ GVT GPLI+E+AV KVE+H+ADAL KGARV+ GGK H Sbjct: 302 YDRFAEKLQQAVSKLHIGDGLDKGVTIGPLIDEKAVAKVEEHIADALEKGARVVCGGKAH 361 Query: 364 ALGHGFFEPTVLADVTPAMQVAREETFGPMAPLFRFKTDDEALSLANDTEFGLASYFYSR 423 G FF+PT+L DV +V++EETFGP+APLFRFK + + ++ ANDTEFGLA+YFY+R Sbjct: 362 ERGGNFFQPTILVDVPANAKVSKEETFGPLAPLFRFKDEADVIAQANDTEFGLAAYFYAR 421 Query: 424 DIGRIWRVAEGLESGMVGINTGLISNEVAPFGGVKQSGLGREGSHYGIDDYLVVKYLCMG 483 D+ R++RV E LE G+VGINTG+ISNEVAPFGG+K SGLGREGS YGI+DYL +KY+C+G Sbjct: 422 DLSRVFRVGEALEYGIVGINTGIISNEVAPFGGIKASGLGREGSKYGIEDYLEIKYMCIG 481 >STM2791 [C] COG1012 NAD-dependent aldehyde dehydrogenases Sty Salmonella typhimurium LT2 Length = 482 Score = 702 bits (1813), Expect = 0.0, Method: Compositional matrix adjust. Identities = 336/480 (70%), Positives = 400/480 (83%) Query: 4 QLKDPSLLRQQAYLNGAWCDADSGAKLEVHNPANGQLLGHVPLMGATETRRAIDAANAAW 63 QL D +L RQQA+++G W DA G + V NPANG+ LG+VP MGA ETR AI+AAN A Sbjct: 2 QLNDSTLFRQQAFIDGDWRDARGGDVIPVSNPANGKPLGNVPKMGAEETRDAINAANRAL 61 Query: 64 PAWKKKTAKERSALLRRWYELMLANADDLALIMTAEQGKPLAEARGEIGYAASFIEWFAE 123 PAW+ TAKER+ +LRRW+ LM+ + DDLA +MT EQGKPLAEA+GEI YAASFIEWFAE Sbjct: 62 PAWRALTAKERANILRRWFNLMMEHQDDLARLMTLEQGKPLAEAKGEISYAASFIEWFAE 121 Query: 124 EGKRTYGDTIPSPSPTNRIVVIKEAIGVCAAITPWNFPAAMITRKAGPALAAGCPMVLKP 183 EGKR YGDTIP R++VIK+ IGV AAITPWNFP+AMITRKAGPALAAGC MVLKP Sbjct: 122 EGKRIYGDTIPGHQADKRLLVIKQPIGVTAAITPWNFPSAMITRKAGPALAAGCTMVLKP 181 Query: 184 AEATPFSALALAVLAERAGIPAGVFSVVTGTPKEIGGEMTSNPIVRKISFTGSTGVGKLL 243 A TPFSALALA LA+RAGIPAGVF+VVTG+ +IGGE+TSNP+VRK+SFTGST +G+ L Sbjct: 182 ASQTPFSALALAELAQRAGIPAGVFNVVTGSAGDIGGELTSNPLVRKLSFTGSTEIGRQL 241 Query: 244 MQQSASSIKKLSLELGGNAPFIVFDDADLDAAVEGAIASKYRNAGQTCVCANRIYVQDGV 303 M+Q A IKK+SLELGGNAPFIVFDDADLD AVEGA+ASK+RNAGQTCVCANR+YVQDGV Sbjct: 242 MEQCAKDIKKVSLELGGNAPFIVFDDADLDKAVEGALASKFRNAGQTCVCANRLYVQDGV 301 Query: 304 YDAFAAKLVEAVKKLKVGDGMENGVTQGPLINEQAVKKVEQHVADALAKGARVLLGGKRH 363 YD FA KL +AV KL VGDG++ V GPLI+E+AV KV++H+ADAL KGARV+ GG+ H Sbjct: 302 YDRFAEKLNQAVNKLAVGDGLQADVAIGPLIDEKAVAKVQEHIADALEKGARVITGGEAH 361 Query: 364 ALGHGFFEPTVLADVTPAMQVAREETFGPMAPLFRFKTDDEALSLANDTEFGLASYFYSR 423 LG FF+PT+LADV +VA+EETFGP+APLFRF + + + ANDTEFGLA+YFY+R Sbjct: 362 KLGGNFFQPTILADVPDNAKVAKEETFGPLAPLFRFSDEADVIRQANDTEFGLAAYFYAR 421 Query: 424 DIGRIWRVAEGLESGMVGINTGLISNEVAPFGGVKQSGLGREGSHYGIDDYLVVKYLCMG 483 D+ R++RV E LE G+VGINTG+ISNEVAPFGG+K SGLGREGS YGI+DYL +KY+C+G Sbjct: 422 DLSRVFRVGEALEYGIVGINTGIISNEVAPFGGIKASGLGREGSKYGIEDYLEIKYMCIG 481