BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.0572.p (245 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PA5281 [R] COG1011 Predicted hydrolase (HAD superfamily) Pae Pse... 126 4e-29 VC0129 [R] COG1011 Predicted hydrolase (HAD superfamily) Vch Vib... 92 8e-19 STM3950 [R] COG1011 Predicted hydrolase (HAD superfamily) Sty Sa... 90 5e-18 PM1700 [R] COG1011 Predicted hydrolase (HAD superfamily) Pmu Pas... 85 2e-16 ECs4742 [R] COG1011 Predicted hydrolase (HAD superfamily) Ecs Es... 80 3e-15 >PA5281 [R] COG1011 Predicted hydrolase (HAD superfamily) Pae Pseudomonas aeruginosa Length = 232 Score = 126 bits (317), Expect = 4e-29, Method: Compositional matrix adjust. Identities = 81/223 (36%), Positives = 117/223 (52%), Gaps = 7/223 (3%) Query: 20 IQAVLFDLDDTLWAIEPVLVRAEGLLYDWLREHAPAVVAAHTIASLRERRMALMQTDPAY 79 ++ V FDLDDTLW + PV+ AE LL +WL +A A + I L R L+ +P Sbjct: 4 LRLVTFDLDDTLWDVAPVMNNAEALLREWLASNA-ARLGPVPIEHLWAIRTRLLDREPML 62 Query: 80 RIDLWKLR-----HTALSQVFREHDVDLALVDPAMALFSEARSTVALFDDVEPALLRLKG 134 R L +LR H L + + + + +L + +F EAR V LF +V P L L Sbjct: 63 RHRLSELRRRILFHALLDAGYPQAEAE-SLAEAGFQVFLEARHRVTLFPEVHPTLEILAD 121 Query: 135 KLTLGSVSNGFADLERIGLAQHFGVSIAAHRFGRAKPDPAIFHAACAALQAAPAATVYVG 194 + TLG ++NG AD+ R+GLA +F ++ A G KPDP F A +A +++G Sbjct: 122 RFTLGVLTNGNADVRRLGLADYFRFALCAEELGVGKPDPTPFREALKRAGVEASAAIHIG 181 Query: 195 DDPLLDVQGAQQAGLRAVWMNRFDRTLPAGILPDAICRDLHEL 237 D P D+ GA++AG+RA+W N + P A R L EL Sbjct: 182 DHPSDDIAGARRAGMRAIWFNPSGKPWAGEEEPSAEIRSLAEL 224 >VC0129 [R] COG1011 Predicted hydrolase (HAD superfamily) Vch Vibrio cholerae Length = 239 Score = 92.4 bits (228), Expect = 8e-19, Method: Compositional matrix adjust. Identities = 70/229 (30%), Positives = 111/229 (48%), Gaps = 11/229 (4%) Query: 18 APIQAVLFDLDDTLWAIEPVLVRAEGLLYDWLREHAPAVVAAHTIASL--RERRMALMQT 75 A IQA+ FDLDDTL+ PV+ + E + +WL P + A +A +R +A Sbjct: 8 ASIQALTFDLDDTLYDNRPVIKQVEEKVTEWLLSEHP-ITATRPLAWWLAMKRDIARRFP 66 Query: 76 DPAYRIDLWK---LRHTALSQVFREHDVDLALVDPAMALFSEARSTVALFDDVEPALLRL 132 + + + W+ ++H L + + + + A + R+ V + + L +L Sbjct: 67 EQCHDVSQWRYLQVQHGLLELGYAQPEAEQA-ASETLEQVMRWRNQVDVPAETHRVLAQL 125 Query: 133 KGKLTLGSVSNGFADLERIGLAQHFGVSIAAHRFGRAKPDPAIFHAACAALQAAPAATVY 192 K+ L +++NG +E+IGL+ +F + A GRAKP P +F A LQ P + ++ Sbjct: 126 AAKVPLIAITNGNVQIEKIGLSGYFQTVLRAGPDGRAKPYPDLFAQAAQQLQLEPRSILH 185 Query: 193 VGDDPLLDVQGAQQAGLRAVWMN----RFDRTLPAGILPDAICRDLHEL 237 VGD DV GA+Q G +A W N R A +LPD L EL Sbjct: 186 VGDHLQTDVLGARQNGFQACWFNDQGQSIRRLAKASVLPDVEIERLSEL 234 >STM3950 [R] COG1011 Predicted hydrolase (HAD superfamily) Sty Salmonella typhimurium LT2 Length = 238 Score = 89.7 bits (221), Expect = 5e-18, Method: Compositional matrix adjust. Identities = 59/200 (29%), Positives = 101/200 (50%), Gaps = 5/200 (2%) Query: 20 IQAVLFDLDDTLWAIEPVLVRAEGLLYDWLREHAPAVVAAHTIASLRERRMALMQTDPAY 79 I A+ FDLDDTL+ PV++R E +++ + P++ + + L+ R A+ + +P Sbjct: 10 IAALTFDLDDTLYDNRPVILRTEQEALAFMQNYHPSLRSFQNV-DLQRIRQAVREAEPEI 68 Query: 80 RIDLWKLRHTALSQVFREHDVD----LALVDPAMALFSEARSTVALFDDVEPALLRLKGK 135 D+ + RH A+ Q R+ + +A + AM F++ RS + + L +L K Sbjct: 69 YHDVTRWRHRAIEQAMRDAGLSAQEAIAGANAAMMHFAKWRSQIEVPQATHETLQQLAKK 128 Query: 136 LTLGSVSNGFADLERIGLAQHFGVSIAAHRFGRAKPDPAIFHAACAALQAAPAATVYVGD 195 L +++NG A E GL +F + A GR+KP ++ A L ++VGD Sbjct: 129 WPLVAITNGNAQPELFGLGDYFKFVLRAGPDGRSKPFSDMYFLAAEKLHVPIGEILHVGD 188 Query: 196 DPLLDVQGAQQAGLRAVWMN 215 D DV GA + G++A W+ Sbjct: 189 DLTTDVAGAIRCGMQACWIK 208 >PM1700 [R] COG1011 Predicted hydrolase (HAD superfamily) Pmu Pasteurella multocida Length = 236 Score = 84.7 bits (208), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 66/227 (29%), Positives = 109/227 (48%), Gaps = 12/227 (5%) Query: 19 PIQAVLFDLDDTLWAIEPVLVRAEGLLYDWLREHAPAVVAAHTIASLRERRMALMQTDPA 78 P + + FDLDDTL+ V+ AE + ++ + +++ + ++R + Q P Sbjct: 9 PFKLISFDLDDTLYDNSDVIRLAEENFIEKVKLESQLNISSEEWRAWKQR---IEQRHPM 65 Query: 79 YRIDLWKLRHTALSQVFREHDVDLALVD----PAMALFSEARSTVALFDDVEPALLRLKG 134 D+ R L Q+ + A ++ AMALF E R + + + L LK Sbjct: 66 LCEDVVAWRIETLHQLLANYQKSAAEIERVCQQAMALFVEWRHKIDVPVQSQQVLNLLKQ 125 Query: 135 KLTLGSVSNGFADLERIGLAQHFGVSIAAHRFGRAKPDPAIFHAACAALQAAPAATVYVG 194 K L +++NG + +RIGL+Q F + + GRAKP +FH P ++VG Sbjct: 126 KYPLVAITNGNVEPQRIGLSQ-FDLVLRGGEQGRAKPHQDLFHQTAQHFGVQPHEILHVG 184 Query: 195 DDPLLDVQGAQQAGLRAVWMNRFDRTL----PAGILPDAICRDLHEL 237 D+ + DVQGA QA +AVW+N + L A ++P +L +L Sbjct: 185 DNLMTDVQGAIQADCQAVWINLSGKVLRDFPEARLMPTLEITELKQL 231 >ECs4742 [R] COG1011 Predicted hydrolase (HAD superfamily) Ecs Escherichia coli O157:H7 Length = 238 Score = 80.5 bits (197), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 57/199 (28%), Positives = 97/199 (48%), Gaps = 5/199 (2%) Query: 20 IQAVLFDLDDTLWAIEPVLVRAEGLLYDWLREHAPAVVAAHTIASLRERRMALMQTDPAY 79 I A+ FDLDDTL+ PV++R E +++ + PA+ + L+ R A+ + +P Sbjct: 10 ISALTFDLDDTLYDNRPVILRTEQEALTFVQNYHPALRSFQN-EDLQRLRQAVREAEPEI 68 Query: 80 RIDLWKLRHTALSQVFREHDVDL----ALVDPAMALFSEARSTVALFDDVEPALLRLKGK 135 D+ + R ++ Q + + A AM F++ RS + + L +L K Sbjct: 69 YHDVTRWRFRSIEQAMLDAGLSAEEASAGAHAAMINFAKWRSRIDVPQQTHDTLKQLAKK 128 Query: 136 LTLGSVSNGFADLERIGLAQHFGVSIAAHRFGRAKPDPAIFHAACAALQAAPAATVYVGD 195 L +++NG A E GL +F + A GR+KP ++ A L ++VGD Sbjct: 129 WPLVAITNGNAQPELFGLGDYFEFVLRAGPHGRSKPFSDMYFLAAEKLNVPIGEILHVGD 188 Query: 196 DPLLDVQGAQQAGLRAVWM 214 D DV GA ++G++A W+ Sbjct: 189 DLTTDVGGAIRSGMQACWI 207