BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.0522.p (455 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value YPO2237 [GEPR] COG0477 Permeases of the major facilitator superf... 338 1e-92 RSc2352 [GEPR] COG0477 Permeases of the major facilitator superf... 337 4e-92 RSp1572 [GEPR] COG0477 Permeases of the major facilitator superf... 335 1e-91 BMEII1096 [GEPR] COG0477 Permeases of the major facilitator supe... 318 2e-86 RSp0182 [GEPR] COG0477 Permeases of the major facilitator superf... 295 2e-79 >YPO2237 [GEPR] COG0477 Permeases of the major facilitator superfamily Ype Yersinia pestis Length = 436 Score = 338 bits (867), Expect = 1e-92, Method: Compositional matrix adjust. Identities = 180/440 (40%), Positives = 263/440 (59%), Gaps = 11/440 (2%) Query: 10 TLAAPPHLNLSVAAEDAIYRKVWLRIIPFLFLCYVVSFLDRINIGFAQLQMKQDLGFSDA 69 +L+ P L E+ YRK ++P L LCYV+++LDR+N+GFA+LQM DL FSD Sbjct: 8 SLSQPTQLQ----EENNAYRKTVWHLLPLLMLCYVLNYLDRVNVGFAKLQMADDLQFSDT 63 Query: 70 MYGLGAAVFYVGYVLCEVPSNMLLARFGARRTFSRIMVLWGLASVGMMAVTDATHFYVLR 129 +YGLGA +F++GY E+PSN++L R GAR +RIM+ WG+ S M VT FYV+R Sbjct: 64 VYGLGAGMFFIGYFFLEIPSNLILHRVGARLWIARIMITWGIISACMAFVTTPMSFYVMR 123 Query: 130 FLLGVFEAGFFPGIVLYLSYWFPARRRAAVMAIFFAGVAVAGVLGGLVSGWIMRDMAGVM 189 FLLGV EAGFFPGI+LY+SYWFP+ RR V +F V ++G++G +SGWIM+ G Sbjct: 124 FLLGVAEAGFFPGIILYISYWFPSHRRGRVYGLFVISVPLSGIIGAPLSGWIMQYFNGFQ 183 Query: 190 GMYGWQWMFAIEGAPAVVLGVLVIFLLADGPAQASWLSPQERSFLLARHTQETQRSQHVK 249 G GWQWMF +EG P+V++G+L+I+ L D A+WL+ +E+ L E H + Sbjct: 184 GYAGWQWMFILEGIPSVLVGILIIYKLKDRITHATWLTDKEKDILQTNIENEAAHYAHSR 243 Query: 250 AHSLTALRHALSHRPTYLFAFIYFALTCGSLTLNFWMPLMIRDFGIKDVVQVSLYTVIPN 309 LR A +L IYF L G T+ FW+P +IRD G+KD++ + T IP+ Sbjct: 244 ------LRDAFLQPRVWLLTLIYFCLISGFYTIGFWLPTLIRDSGVKDILSIGFLTAIPS 297 Query: 310 AIGAIGLILIARRSDRRNERHGHFLFCTTGGALALAALTLHPSSLAVSLGLLSLAAVLIF 369 A A+ +I+++R +DR ER H GA+ + T ++ V++ L++ A+ Sbjct: 298 AAAAVTMIVVSRSADRLRERRWHLALTAVLGAVGIILSTYFSDNIVVAMVCLTIGAMGAL 357 Query: 370 AALPIFWSLPPGLLPAQTIAPGIAFISSVGITSGIVSPWLIGLIKTRTGNIDIALYILAG 429 + +P+FWSLP L A GIAFI+S G G V+P+++G +K T + + I++ Sbjct: 358 STIPLFWSLPTAFLGGSAAAAGIAFINSWGNLGGFVAPYMMGYLKDLTQSTTTGMLIIST 417 Query: 430 LLLLSGLTMWGLIPRKATQE 449 L + G + LIP KA Sbjct: 418 TLFI-GAALVFLIPAKAVNH 436 >RSc2352 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 442 Score = 337 bits (863), Expect = 4e-92, Method: Compositional matrix adjust. Identities = 187/436 (42%), Positives = 269/436 (61%), Gaps = 12/436 (2%) Query: 3 TPSPGATTLAAPPHLNLSVAAEDAIYRKVWLRIIPFLFLCYVVSFLDRINIGFAQLQMKQ 62 TP G + A PP + E+A YRKV R+IPFL LCYVV++LDR+N+GFA+LQM Sbjct: 5 TPPLGPSAGALPPQS--ASGFEEATYRKVSWRLIPFLLLCYVVAYLDRVNVGFAKLQMLN 62 Query: 63 DLGFSDAMYGLGAAVFYVGYVLCEVPSNMLLARFGARRTFSRIMVLWGLASVGMMAVTDA 122 DL FS+ +YGLGA +F++GY L EVPSN++L R GAR +RIM+ WGL S MM VT Sbjct: 63 DLKFSETVYGLGAGIFFIGYFLFEVPSNVILHRVGARMWIARIMISWGLISAAMMFVTTP 122 Query: 123 THFYVLRFLLGVFEAGFFPGIVLYLSYWFPARRRAAVMAIFFAGVAVAGVLGGLVSGWIM 182 FYV+RFLLG+ EAGFFPGI+LYL+YW+PA RR F VA++GV+GG +SGW + Sbjct: 123 AMFYVMRFLLGLAEAGFFPGIILYLTYWYPAERRGRTTTFFMTAVALSGVIGGPISGWAL 182 Query: 183 RDMAGVMGMYGWQWMFAIEGAPAVVLGVLVIFLLADGPAQASWLSPQERSFLLARH--TQ 240 + GV G+ GWQWMF IEG P+VV+G+ V+ L + + A WL+ +E++ LL R+ + Sbjct: 183 KTFGGVYGLAGWQWMFLIEGIPSVVIGLCVLAYLDNRISHARWLTDEEKA-LLTRNIAAE 241 Query: 241 ETQRSQHVKAHSLTALRHALSHRPTYLFAFIYFALTCGSLTLNFWMPLMIRDFGIKDVVQ 300 E Q+ A + + R +L + IYF+ G ++FW+P +I+ G+ D + Sbjct: 242 EAQKEDAPIAAIMASPR-------VWLMSLIYFSFVMGLYGVSFWLPTLIKQTGVADPLS 294 Query: 301 VSLYTVIPNAIGAIGLILIARRSDRRNERHGHFLFCTTGGALALAALTLHPSSLAVSLGL 360 V L T IP + ++L+AR +DR ER H GA+ L + ++ +++ Sbjct: 295 VGLLTAIPYGAAVVAMVLVARSADRTRERRWHIAIPALAGAIGLVLSAVWHTNTTLAMAA 354 Query: 361 LSLAAVLIFAALPIFWSLPPGLLPAQTIAPGIAFISSVGITSGIVSPWLIGLIKTRTGNI 420 L+L + I LP+FWSLP L A GIA I+S+G +G +SP+ +G +K T + Sbjct: 355 LTLGTMGILTTLPLFWSLPTAFLAGTGAAAGIALINSLGNLAGFLSPYAVGWLKDTTRST 414 Query: 421 DIALYILAGLLLLSGL 436 D +Y+LA ++L L Sbjct: 415 DSGMYLLAASMVLGAL 430 >RSp1572 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 433 Score = 335 bits (860), Expect = 1e-91, Method: Compositional matrix adjust. Identities = 175/398 (43%), Positives = 241/398 (60%), Gaps = 8/398 (2%) Query: 24 EDAIYRKVWLRIIPFLFLCYVVSFLDRINIGFAQLQMKQDLGFSDAMYGLGAAVFYVGYV 83 ++Y V RI+PFL CY+ ++LDRINIGFA+LQM+ DL SDA YGLGA +F+ GY+ Sbjct: 16 STSVYSVVNRRILPFLATCYLFAYLDRINIGFAKLQMQNDLALSDAAYGLGAGIFFFGYM 75 Query: 84 LCEVPSNMLLARFGARRTFSRIMVLWGLASVGMMAVTDATHFYVLRFLLGVFEAGFFPGI 143 L EVPSN+LL + GARRT SRI++LWG+ S M+ VTD FY LRFLLGVFEAGF PG+ Sbjct: 76 LFEVPSNLLLVKIGARRTLSRILILWGIVSASMLFVTDVWTFYALRFLLGVFEAGFAPGM 135 Query: 144 VLYLSYWFPARRRAAVMAIFFAGVAVAGVLGGLVSGWIMRDMAGVMGMYGWQWMFAIEGA 203 + YL+ W+P R A MA+ + GV+GG S WIM AG G+ GWQWMF EG Sbjct: 136 IYYLTQWYPGERMARAMAVVLGAAPLGGVIGGPASTWIMGHFAGAGGLAGWQWMFLAEGI 195 Query: 204 PAVVLGVLVIFLLADGPAQASWLSPQERSFLLARHTQETQRSQHVKAHSLTALRHALSHR 263 P+++LG+ L D PA A WL+ +++ + + R+ +A S AL+ Sbjct: 196 PSILLGIAAYGYLVDKPADARWLTDAQKAVI----AGDIARAAPGQASSFG---KALTEP 248 Query: 264 PTYLFAFIYFALTCGSLTLNFWMPLMIRDFGIKDVVQVSLYTVIPNAIGAIGLILIARRS 323 Y+ A YF L CG + FW+P +++ G+ D+ Q+ LY+ IPN + + + RRS Sbjct: 249 KLYVLAAAYFCLICGVYAVGFWLPSILKSAGLSDLFQIGLYSAIPNLAMIVAMYALGRRS 308 Query: 324 DRRNERHGHFLFCTTGGALALAALTLHPSSLAVSLGLLSLAAVLIFAALPIFWSLPPGLL 383 DRR ERH H GA L A + +S +L ++LA+ IFA+ +FW++P L Sbjct: 309 DRRGERHLHSAITAVLGA-GLLAWAAYATSFPAALISITLASAAIFASYSVFWAIPQQHL 367 Query: 384 PAQTIAPGIAFISSVGITSGIVSPWLIGLIKTRTGNID 421 A GIA I+S+G+ G SP LIG K TG++ Sbjct: 368 KGTAAAGGIALINSIGLFGGFFSPTLIGWTKEATGSLQ 405 >BMEII1096 [GEPR] COG0477 Permeases of the major facilitator superfamily Bme Brucella melitensis Length = 451 Score = 318 bits (815), Expect = 2e-86, Method: Compositional matrix adjust. Identities = 168/410 (40%), Positives = 252/410 (61%), Gaps = 6/410 (1%) Query: 24 EDAIYRKVWLRIIPFLFLCYVVSFLDRINIGFAQLQMKQDLGFSDAMYGLGAAVFYVGYV 83 E+ YRKV RIIP L +CY++++LDR+N+GFA+LQM ++LGFS+A+YGLGA +F++GY Sbjct: 33 ENMTYRKVAFRIIPLLMICYIIAYLDRVNVGFAKLQMSEELGFSEAIYGLGAGLFFIGYF 92 Query: 84 LCEVPSNMLLARFGARRTFSRIMVLWGLASVGMMAVTDATHFYVLRFLLGVFEAGFFPGI 143 E+PSN+LL + GAR +RIM+ WGL S V FY+LRFLLG EAGF+PG+ Sbjct: 93 FFEIPSNILLHKLGARLWIARIMITWGLLSALFAFVQTEWQFYILRFLLGAAEAGFYPGV 152 Query: 144 VLYLSYWFPARRRAAVMAIFFAGVAVAGVLGGLVSGWIMRDMAGVMGMYGWQWMFAIEGA 203 +LYL+YWFP+ RR + A+F AG AG+ G +SGWIM G GWQWMF +E Sbjct: 153 ILYLTYWFPSHRRGNMFALFQAGSPAAGIFGNPLSGWIMDQFHDTAGWQGWQWMFVLEAI 212 Query: 204 PAVVLGVLVIFLLADGPAQASWLSPQERSFLLARHTQETQRSQHVKAHSLTALRHALSHR 263 PAVVLGV+++ L + A WL+ +E++ +++R + + + +HSL +L + + Sbjct: 213 PAVVLGVVILLYLDNSVKAAKWLTEEEKA-IISRDIEADSKGK-AASHSLMSL---VKNP 267 Query: 264 PTYLFAFIYFALTCGSLTLNFWMPLMIRDFGIKDVVQVSLYTVIPNAIGAIGLILIARRS 323 ++ IYF G L WMP +IR G+ V + L IP I +++ +R + Sbjct: 268 MLWVMMLIYFCFVMGQHGLTLWMPTLIRASGVTSNVTIGLLGAIPFICAIIAMVIFSRSA 327 Query: 324 DRRNERHGHFLFCTTGGALALAALTLHPSSLAVSLGLLSLAAVLIFAALPIFWSLPPGLL 383 D ER H + GA+ + ++ VS+ LS+AA + A P+FWSLP +L Sbjct: 328 DHYRERRWHLVVPALLGAVGF-VVAASATNTTVSIIFLSMAAAGVLACAPLFWSLPTAIL 386 Query: 384 PAQTIAPGIAFISSVGITSGIVSPWLIGLIKTRTGNIDIALYILAGLLLL 433 A GIA I+SV +G +SP+++G+I+ T + ++ +Y+LAG L+L Sbjct: 387 SGAAAAAGIALINSVANLAGFISPYMVGIIRDATHSSELGMYVLAGFLIL 436 >RSp0182 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 453 Score = 295 bits (755), Expect = 2e-79, Method: Compositional matrix adjust. Identities = 175/394 (44%), Positives = 230/394 (58%), Gaps = 10/394 (2%) Query: 24 EDAIYRKVWLRIIPFLFLCYVVSFLDRINIGFAQLQMKQDLGFSDAMYGLGAAVFYVGYV 83 E AI RK+ RI+PF+F Y++S+LDR NIG+A LQM Q+L S +G + +F++GY Sbjct: 26 ERAIVRKITWRILPFVFALYIISYLDRANIGYAALQMNQELALSSEAFGFVSGIFFIGYF 85 Query: 84 LCEVPSNMLLARFGARRTFSRIMVLWGLASVGMMAVTDATHFYVLRFLLGVFEAGFFPGI 143 L EVPSN++L RFGARR +RI+V WGL ++G V AT Y LRFLLGV EAGFFPGI Sbjct: 86 LFEVPSNLMLNRFGARRWIARILVTWGLVAMGSAFVQSATQLYALRFLLGVAEAGFFPGI 145 Query: 144 VLYLSYWFPARRRAAVMAIFFAGVAVAGVLGGLVSGWIMRDMAGVMGMYGWQWMFAIEGA 203 ++YL+YWF AR A +A+F A + V+ V+G +S WIM D + GW+WM +EGA Sbjct: 146 IVYLTYWFRARELATTVALFTAAIPVSYVVGAPLSTWIM-DHVHWLQWSGWRWMLLLEGA 204 Query: 204 PAVVLGVLVIFLLADGPAQASWLSPQERSFLLARHTQETQRSQHVKAHSLTALRHALSHR 263 PAV+ G+L LAD P A WLS ER +LLA E R A L L+ ++H Sbjct: 205 PAVIGGLLCYGYLADRPKDARWLSEAERDWLLAE--LERDRKARPAAAHLATLK-VMTHP 261 Query: 264 PTYLFAFIYFALTCGSLTLNFWMPLMIRDFGIK-DVVQVSLYTVIPNAIGAIGLILIARR 322 AFIYF CGSL + +WMP +I+ F +V L ++P +I +RR Sbjct: 262 RVLYLAFIYFVYQCGSLGIGYWMPQIIKGFSSALSHTEVGLIAMLPYVFATAVMIWWSRR 321 Query: 323 SDRRNERHGHFLFCTTGGALAL--AALTLHPSSLAVSLGLLSLAAVLIFAALPIFWSLPP 380 SD R ER H ALA A HP AV++ +LSL+ ++A FW+LP Sbjct: 322 SDLRAERRLHSAVPLGVAALAFVGAGFIGHP---AVAMAMLSLSLAGLYAFKSPFWALPT 378 Query: 381 GLLPAQTIAPGIAFISSVGITSGIVSPWLIGLIK 414 L T A IA I+SVG G V P+ IG K Sbjct: 379 LFLTRSTAAVSIAVINSVGNLGGFVGPFAIGYFK 412