BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.0517.p (484 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value yebQ [GEPR] COG0477 Permeases of the major facilitator superfami... 324 2e-88 Z2875 [GEPR] COG0477 Permeases of the major facilitator superfam... 324 2e-88 ECs2538 [GEPR] COG0477 Permeases of the major facilitator superf... 324 2e-88 BMEII0280 [GEPR] COG0477 Permeases of the major facilitator supe... 321 3e-87 YPO1712 [GEPR] COG0477 Permeases of the major facilitator superf... 305 1e-82 >yebQ [GEPR] COG0477 Permeases of the major facilitator superfamily Eco Escherichia coli K12 Length = 494 Score = 324 bits (831), Expect = 2e-88, Method: Compositional matrix adjust. Identities = 183/421 (43%), Positives = 256/421 (60%), Gaps = 8/421 (1%) Query: 11 EGLPGQQRRRAMLAVMTATTMAVFDGTIINVALPQISLALHTSAAASVWVANAYLLATAM 70 +GLP QR A+L ++ +MAV DG I NVALP I+ LH + A+S+WV NAY +A + Sbjct: 44 DGLPLPQRYGAILTIVIGISMAVLDGAIANVALPTIATDLHATPASSIWVVNAYQIAIVI 103 Query: 71 TLAVFAALSSRLGFRTQFTAGLAVFTLASLGCALSRSVEWLIAMRVLQGLGGAAMLSIAP 130 +L F+ L G+R + GL VF L+SL CALS S++ L RV+QG GGAA++S+ Sbjct: 104 SLLSFSFLGDMFGYRRIYKCGLVVFLLSSLFCALSDSLQMLTLARVIQGFGGAALMSVNT 163 Query: 131 AIHRTVFPNRLLGRILGLNAVLVAAGTAVGPVLGGTLLAALSWEWIFLINLPLGMVGVLL 190 A+ R ++P R LGR +G+N+ +VA +A GP + +L+ SW+W+FLIN+PLG++ +LL Sbjct: 164 ALIRLIYPQRFLGRGMGINSFIVAVSSAAGPTIAAAILSIASWKWLFLINVPLGIIALLL 223 Query: 191 AWSAIPET-RKPARARFDIAGACWSALAMGALIMAADTCARLAEPGQGTQATLQAAAYAL 249 A +P + ++ RFD+ A +AL G LI A A QG TL AA + Sbjct: 224 AMRFLPPNGSRASKPRFDLPSAVMNALTFGLLITALSGFA------QGQSLTLIAAEL-V 276 Query: 250 VALLAALAFVRGQRRAPEPLLPLDIFANARFSLAALTSLVSFVGQGIAFVALPFLFQNGY 309 V ++ + F+R Q P PLLP+D+ FSL+ TS+ SF Q +A V+LPF Q Sbjct: 277 VMVVVGIFFIRRQLSLPVPLLPVDLLRIPLFSLSICTSVCSFCAQMLAMVSLPFYLQTVL 336 Query: 310 GYSAFESAALFTPWPLGIVLVAPHAGRLADRHSPALLSSLGLALFTVGLALLALLPAHAQ 369 G S E+ L TPWPL +++AP AG L +R LL +LGL + GL L LLPA Sbjct: 337 GRSEVETGLLLTPWPLATMVMAPLAGYLIERVHAGLLGALGLFIMAAGLFSLVLLPASPA 396 Query: 370 AWDIGWRALVCGMGFGFFQSPNNREMLGNVSRERSGNASGVLAIMRTFGQCLGAALLGMI 429 +I W ++CG GFG FQSPNN ++ + RERSG ASG+L R GQ GAAL+ ++ Sbjct: 397 DINIIWPMILCGAGFGLFQSPNNHTIITSAPRERSGGASGMLGTARLLGQSSGAALVALM 456 Query: 430 L 430 L Sbjct: 457 L 457 >Z2875 [GEPR] COG0477 Permeases of the major facilitator superfamily EcZ Escherichia coli O157:H7 EDL933 Length = 494 Score = 324 bits (831), Expect = 2e-88, Method: Compositional matrix adjust. Identities = 183/421 (43%), Positives = 256/421 (60%), Gaps = 8/421 (1%) Query: 11 EGLPGQQRRRAMLAVMTATTMAVFDGTIINVALPQISLALHTSAAASVWVANAYLLATAM 70 +GLP QR A+L ++ +MAV DG I NVALP I+ LH + A+S+WV NAY +A + Sbjct: 44 DGLPLPQRYGAILTIVIGISMAVLDGAIANVALPTIATDLHATPASSIWVVNAYQIAIVI 103 Query: 71 TLAVFAALSSRLGFRTQFTAGLAVFTLASLGCALSRSVEWLIAMRVLQGLGGAAMLSIAP 130 +L F+ L G+R + GL VF L+SL CALS S++ L RV+QG GGAA++S+ Sbjct: 104 SLLSFSFLGDMFGYRRIYKCGLVVFLLSSLFCALSDSLQILTLARVIQGFGGAALMSVNT 163 Query: 131 AIHRTVFPNRLLGRILGLNAVLVAAGTAVGPVLGGTLLAALSWEWIFLINLPLGMVGVLL 190 A+ R ++P R LGR +G+N+ +VA +A GP + +L+ SW+W+FLIN+PLG++ +LL Sbjct: 164 ALIRLIYPQRFLGRGMGINSFIVAVSSAAGPTIAAAILSIASWKWLFLINVPLGIIALLL 223 Query: 191 AWSAIPET-RKPARARFDIAGACWSALAMGALIMAADTCARLAEPGQGTQATLQAAAYAL 249 A +P + ++ RFD+ A +AL G LI A A QG TL AA + Sbjct: 224 AMRFLPPNGSRASKPRFDLPSAVMNALTFGLLITALSGFA------QGQSLTLIAAEL-V 276 Query: 250 VALLAALAFVRGQRRAPEPLLPLDIFANARFSLAALTSLVSFVGQGIAFVALPFLFQNGY 309 V ++ + F+R Q P PLLP+D+ FSL+ TS+ SF Q +A V+LPF Q Sbjct: 277 VMVVVGIFFIRRQLSLPVPLLPVDLLRIPLFSLSICTSVCSFCAQMLAMVSLPFYLQTVL 336 Query: 310 GYSAFESAALFTPWPLGIVLVAPHAGRLADRHSPALLSSLGLALFTVGLALLALLPAHAQ 369 G S E+ L TPWPL +++AP AG L +R LL +LGL + GL L LLPA Sbjct: 337 GRSEVETGLLLTPWPLATMVMAPLAGYLIERVHAGLLGALGLFIMAAGLFSLVLLPASPA 396 Query: 370 AWDIGWRALVCGMGFGFFQSPNNREMLGNVSRERSGNASGVLAIMRTFGQCLGAALLGMI 429 +I W ++CG GFG FQSPNN ++ + RERSG ASG+L R GQ GAAL+ ++ Sbjct: 397 DINIIWPMILCGAGFGLFQSPNNHTIITSAPRERSGGASGMLGTARLLGQSSGAALVALM 456 Query: 430 L 430 L Sbjct: 457 L 457 >ECs2538 [GEPR] COG0477 Permeases of the major facilitator superfamily Ecs Escherichia coli O157:H7 Length = 494 Score = 324 bits (831), Expect = 2e-88, Method: Compositional matrix adjust. Identities = 183/421 (43%), Positives = 256/421 (60%), Gaps = 8/421 (1%) Query: 11 EGLPGQQRRRAMLAVMTATTMAVFDGTIINVALPQISLALHTSAAASVWVANAYLLATAM 70 +GLP QR A+L ++ +MAV DG I NVALP I+ LH + A+S+WV NAY +A + Sbjct: 44 DGLPLPQRYGAILTIVIGISMAVLDGAIANVALPTIATDLHATPASSIWVVNAYQIAIVI 103 Query: 71 TLAVFAALSSRLGFRTQFTAGLAVFTLASLGCALSRSVEWLIAMRVLQGLGGAAMLSIAP 130 +L F+ L G+R + GL VF L+SL CALS S++ L RV+QG GGAA++S+ Sbjct: 104 SLLSFSFLGDMFGYRRIYKCGLVVFLLSSLFCALSDSLQILTLARVIQGFGGAALMSVNT 163 Query: 131 AIHRTVFPNRLLGRILGLNAVLVAAGTAVGPVLGGTLLAALSWEWIFLINLPLGMVGVLL 190 A+ R ++P R LGR +G+N+ +VA +A GP + +L+ SW+W+FLIN+PLG++ +LL Sbjct: 164 ALIRLIYPQRFLGRGMGINSFIVAVSSAAGPTIAAAILSIASWKWLFLINVPLGIIALLL 223 Query: 191 AWSAIPET-RKPARARFDIAGACWSALAMGALIMAADTCARLAEPGQGTQATLQAAAYAL 249 A +P + ++ RFD+ A +AL G LI A A QG TL AA + Sbjct: 224 AMRFLPPNGSRASKPRFDLPSAVMNALTFGLLITALSGFA------QGQSLTLIAAEL-V 276 Query: 250 VALLAALAFVRGQRRAPEPLLPLDIFANARFSLAALTSLVSFVGQGIAFVALPFLFQNGY 309 V ++ + F+R Q P PLLP+D+ FSL+ TS+ SF Q +A V+LPF Q Sbjct: 277 VMVVVGIFFIRRQLSLPVPLLPVDLLRIPLFSLSICTSVCSFCAQMLAMVSLPFYLQTVL 336 Query: 310 GYSAFESAALFTPWPLGIVLVAPHAGRLADRHSPALLSSLGLALFTVGLALLALLPAHAQ 369 G S E+ L TPWPL +++AP AG L +R LL +LGL + GL L LLPA Sbjct: 337 GRSEVETGLLLTPWPLATMVMAPLAGYLIERVHAGLLGALGLFIMAAGLFSLVLLPASPA 396 Query: 370 AWDIGWRALVCGMGFGFFQSPNNREMLGNVSRERSGNASGVLAIMRTFGQCLGAALLGMI 429 +I W ++CG GFG FQSPNN ++ + RERSG ASG+L R GQ GAAL+ ++ Sbjct: 397 DINIIWPMILCGAGFGLFQSPNNHTIITSAPRERSGGASGMLGTARLLGQSSGAALVALM 456 Query: 430 L 430 L Sbjct: 457 L 457 >BMEII0280 [GEPR] COG0477 Permeases of the major facilitator superfamily Bme Brucella melitensis Length = 463 Score = 321 bits (822), Expect = 3e-87, Method: Compositional matrix adjust. Identities = 190/468 (40%), Positives = 272/468 (58%), Gaps = 24/468 (5%) Query: 11 EGLPGQQRRRAMLAVMTATTMAVFDGTIINVALPQISLALHTSAAASVWVANAYLLATAM 70 +GLP + A +M T+AV DGTI NVALP I+ AAS+W+ N Y LA + Sbjct: 20 DGLPRPRIYWAWATLMVGLTLAVIDGTIANVALPTIAADFSAGPAASIWIVNGYQLAIVI 79 Query: 71 TLAVFAALSSRLGFRTQFTAGLAVFTLASLGCALSRSVEWLIAMRVLQGLGGAAMLSIAP 130 T+ AAL G+R + AG+A+FT+AS+GC SRS+E L R++QGLG A ++S+ Sbjct: 80 TMLPLAALGEIYGYRRVYVAGVALFTIASIGCVFSRSLEALTLARIIQGLGAAGLMSVNT 139 Query: 131 AIHRTVFPNRLLGRILGLNAVLVAAGTAVGPVLGGTLLAALSWEWIFLINLPLGMVGVLL 190 A+ R P G +GLNA+ VA + +GP L G +L++LSW W+F+IN+PLG+ VL+ Sbjct: 140 ALLRYTVPQAKFGTAIGLNALFVAVSSTIGPSLAGVMLSSLSWPWLFVINIPLGIAAVLM 199 Query: 191 AWSAIPETRKPARARFDIAGACWSALAMGALIMAADTCARLAEPGQGTQATLQAAAYALV 250 ++P+ + AR +FD+ A A+ G LI D+ +L AL Sbjct: 200 GLRSLPDNDRSAR-KFDVVSAILCAVTFGLLITTIDSAGN-------KIGSLAVMLQALC 251 Query: 251 ALLAALAFVRGQRRAPEPLLPLDIFANARFSLAALTSLVSFVGQGIAFVALPFLFQNGYG 310 LLA + R +PLLPLD+ F+L+ TS++SF+ Q +AF++LPFLFQ +G Sbjct: 252 CLLAGIWLTRRSFHMSDPLLPLDLLRIPVFTLSICTSIMSFLAQMMAFISLPFLFQTVFG 311 Query: 311 YSAFESAALFTPWPLGIVLVAPHAGRLADRHSPALLSSLGLALFTVGLALLALLPAHAQA 370 + E L PWP+ + LVAP +G+L+D++SPA+L LGL F+VGLAL+ LLP H Sbjct: 312 FRPIEVGFLMMPWPIALALVAPLSGKLSDKYSPAILGLLGLITFSVGLALVGLLPGHPTI 371 Query: 371 WDIGWRALVCGMGFGFFQSPNNREMLGNVSRERSGNASGVLAIMRTFGQCLGAALLGMIL 430 DI WR +CG+GFG FQ+PNNR M+ + R RSG ASG+L R GQ +GAAL+ +L Sbjct: 372 PDICWRMAICGIGFGLFQAPNNRMMITSTPRARSGAASGMLGTARLLGQSVGAALVAFLL 431 Query: 431 AIYTAHAVEQGSLQMSALEDGEAIRVALWVATAATALATAVSASRLRR 478 + + E L++A+ A+ +S SRLR Sbjct: 432 SQWGV----------------EGTPYILFLASGFALFASVISISRLRH 463 >YPO1712 [GEPR] COG0477 Permeases of the major facilitator superfamily Ype Yersinia pestis Length = 455 Score = 305 bits (782), Expect = 1e-82, Method: Compositional matrix adjust. Identities = 177/431 (41%), Positives = 250/431 (58%), Gaps = 8/431 (1%) Query: 10 DEGLPGQQRRRAMLAVMTATTMAVFDGTIINVALPQISLALHTSAAASVWVANAYLLATA 69 +GLP QR A+L + MAV DGTI NVALP I+ L+TS A S+WV NAY LA Sbjct: 6 SDGLPVPQRYAAILVIALGIMMAVLDGTIANVALPTIARDLNTSPATSIWVVNAYQLAIT 65 Query: 70 MTLAVFAALSSRLGFRTQFTAGLAVFTLASLGCALSRSVEWLIAMRVLQGLGGAAMLSIA 129 ++L A+L +G+R + AGL +F++ SL CALS S+ L RVLQG G AA++S+ Sbjct: 66 ISLLSMASLGDIIGYRRVYQAGLLIFSVTSLFCALSDSLWTLTFARVLQGFGAAALMSVN 125 Query: 130 PAIHRTVFPNRLLGRILGLNAVLVAAGTAVGPVLGGTLLAALSWEWIFLINLPLGMVGVL 189 A+ R ++P LGR +G+N ++VA +A GP + +L+ SW+W+F +N+P+G++ Sbjct: 126 TALIRIIYPRAQLGRGIGINTLIVAVSSAAGPSIAAAVLSVASWQWLFALNVPIGLLAWC 185 Query: 190 LAWSAIP-ETRKPARARFDIAGACWSALAMGALIMAADTCARLAEPGQGTQATLQAAAYA 248 L +P K RFDI +AL G LI A ++ P A + A A Sbjct: 186 LGIKFLPANNTKSNGNRFDITSCVLNALTFGLLITAISGFSQGQSP-----AVIAAQVVA 240 Query: 249 LVALLAALAFVRGQRRAPEPLLPLDIFANARFSLAALTSLVSFVGQGIAFVALPFLFQNG 308 L LL FVR Q PLLP+D+ F+L+ TS+ SF Q +A V+LPF Q Sbjct: 241 L--LLIGFFFVRRQLTQSFPLLPVDLLRIPIFALSIGTSIFSFAAQMLAMVSLPFFLQTV 298 Query: 309 YGYSAFESAALFTPWPLGIVLVAPHAGRLADRHSPALLSSLGLALFTVGLALLALLPAHA 368 G + L TPWPL +++AP AGRL +R+ LL +GLA+F GL LLA+LPA+ Sbjct: 299 LGRDEVATGLLLTPWPLATMVIAPIAGRLVERYHAGLLGGIGLAVFASGLFLLAVLPANP 358 Query: 369 QAWDIGWRALVCGMGFGFFQSPNNREMLGNVSRERSGNASGVLAIMRTFGQCLGAALLGM 428 DI WR ++CG GFG FQ+PNN ++ + RSG ASG+L R GQ GAAL+ + Sbjct: 359 SDVDIIWRMILCGAGFGLFQTPNNHTIISAAPQHRSGGASGMLGTARLLGQTSGAALVAL 418 Query: 429 ILAIYTAHAVE 439 + +++ + Sbjct: 419 MFNMFSTNGTH 429