BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.0474.p (1048 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc0010 [V] COG0841 Cation/multidrug efflux pump Rso Ralstonia s... 1609 0.0 SMc02867 [V] COG0841 Cation/multidrug efflux pump Sme Sinorhizob... 1353 0.0 AGl3217 [V] COG0841 Cation/multidrug efflux pump Atu Agrobacteri... 1285 0.0 STM0475 [V] COG0841 Cation/multidrug efflux pump Sty Salmonella ... 1219 0.0 acrB [V] COG0841 Cation/multidrug efflux pump Eco Escherichia co... 1206 0.0 >RSc0010 [V] COG0841 Cation/multidrug efflux pump Rso Ralstonia solanacearum Length = 1049 Score = 1609 bits (4166), Expect = 0.0, Method: Compositional matrix adjust. Identities = 795/1044 (76%), Positives = 906/1044 (86%), Gaps = 2/1044 (0%) Query: 1 MGKFFIDRPVFAWVLAIFIMLAGALAITGLPVSQYPNIAPPTIVVTATYPGATAQTLDDS 60 M KFFIDRPVFAWVLA+FI++AGA++IT LP++QYP IAPP+I++TATYPGA+A+TLDD+ Sbjct: 1 MAKFFIDRPVFAWVLALFIIVAGAISITQLPIAQYPTIAPPSIIITATYPGASAKTLDDA 60 Query: 61 VTSLIEQEMNGADGLQYIESQSQA-NGQVQITVTFSPETNPDLAAVDVQNRLKRVEARLP 119 VTS+IEQEMNGADGL YIES SQA NGQ ITVTF P T+P LA VDVQNRLKRVEARLP Sbjct: 61 VTSIIEQEMNGADGLLYIESVSQAGNGQATITVTFKPGTDPALAQVDVQNRLKRVEARLP 120 Query: 120 AAVTQQGVQVTKSRSNFLLFIGLSSTDGKLDPVALGDYLSRNVLNEIKRVPGVGQAQLFG 179 ++VTQQGVQV K+RSNFLLF L S DGK+DPVALGDY+SRNVLNE+KRVPGVGQA LFG Sbjct: 121 SSVTQQGVQVDKTRSNFLLFATLISKDGKMDPVALGDYISRNVLNEVKRVPGVGQAVLFG 180 Query: 180 TERAMRIWIDPNKLIGLNLTPGDVTAAITAQNALVAGGTLGALPSPGTQQIAATVVVNGQ 239 TERAMRIWIDP KL+G LTP DV AI QNALV+ GTLG LPS Q IAATVVV GQ Sbjct: 181 TERAMRIWIDPAKLVGYKLTPTDVYNAIRNQNALVSAGTLGDLPSTSDQPIAATVVVEGQ 240 Query: 240 LTSPEQFGNIVLRANADGSTVRLRDVARVEMGGQSYDTSGRLDGKPSSFIGVQLSPTANA 299 +T+ EQFGNIVL + DGS VR++DVAR+E+GGQ+Y TS R++G+P S IGVQLSPT NA Sbjct: 241 MTTTEQFGNIVLVSKPDGSQVRIKDVARLELGGQTYATSARINGQPISAIGVQLSPTGNA 300 Query: 300 LGTATAVHKKMEELAKYFPAGVKYTIPYDTSKFVKISIEEVVKTLIEAIVLVFLVMFLFL 359 LGTA AV K++EL+KYFPAGV+Y IPYDTSKFV+ISIEEVVKTL EA+ LVFLVM +FL Sbjct: 301 LGTAKAVKAKLDELSKYFPAGVEYKIPYDTSKFVQISIEEVVKTLFEAMALVFLVMLVFL 360 Query: 360 QNIRYTIIPTIVVPVALLGTFATLLLFGFSINVLTMFGMVLAIGILVDDAIVVVENVERI 419 QNIRYT+IP+IVVP++LLG FAT+ GFSINVLTMFG+VLAIGILVDDAIVVVENVERI Sbjct: 361 QNIRYTLIPSIVVPISLLGAFATMNALGFSINVLTMFGLVLAIGILVDDAIVVVENVERI 420 Query: 420 MSEEGLSPPEATRKAMGQISGALIGITLVLIAVFIPMAFFGGAVGAIYRQFSLSMVASMV 479 MS+EGL P EATRKAMGQI+GA+IGITLVL+AVFIPMAFF G+VGAIYRQFSLSMVAS+ Sbjct: 421 MSQEGLPPREATRKAMGQITGAIIGITLVLMAVFIPMAFFSGSVGAIYRQFSLSMVASIF 480 Query: 480 FSVLMAFTLTPALCATILKPVEKGHHHEKKGFFGWFNRKFNSTASGYQGVISKMLNKAGR 539 FS LMA TLTPALC+T+LKP+EKG HHEKKGFFGWFNR F ST YQ ++ ++L K R Sbjct: 481 FSALMALTLTPALCSTLLKPIEKGSHHEKKGFFGWFNRMFTSTTDRYQSLVERVLKKTFR 540 Query: 540 YMIVYVVIVACVGLLYVRLPASFLPNEDQGYIITNVQLPPGASTARTLEVVKKIEQYYLK 599 YM++Y ++A V L++RLP+SFLPNEDQGYIITN+QLPP AS RTLEV+K +E YY Sbjct: 541 YMVIYGALIAAVVFLFMRLPSSFLPNEDQGYIITNIQLPPAASANRTLEVIKHVENYYQH 600 Query: 600 DTAVEHAIAVLGYSFSGNGQNAALVFTPLKDWSERDKSQSADAIAGKAFGA-FSQIKDAI 658 + AVE+ +AV G+SFSGNG NAALVFT LKDWS R QSADA+AG+AFGA F I+DAI Sbjct: 601 EKAVENIVAVQGFSFSGNGPNAALVFTTLKDWSSRGADQSADAVAGRAFGALFGGIRDAI 660 Query: 659 VFPLNPPPIPELGNATGFTFRLQDRAGLGHAALVQARNQILGMAAQSKVLAGVRPEGLED 718 VFPLNPPPIPELGNATGFTFRLQDR GLGH AL+ ARNQ+LGMA QSKVL VRP+GLED Sbjct: 661 VFPLNPPPIPELGNATGFTFRLQDRGGLGHDALMAARNQLLGMAGQSKVLKNVRPDGLED 720 Query: 719 APQLQLDIDRDKANALGVPFSTINSVLSTALGSSYVNDFPNQGRQQRVIVQADANQRLQP 778 +PQ Q+DIDR+KANALGV F+ IN+VLSTALGS+Y NDFPN GRQQRVIVQAD R+QP Sbjct: 721 SPQYQVDIDREKANALGVAFADINNVLSTALGSAYANDFPNYGRQQRVIVQADRINRMQP 780 Query: 779 EDLTNLYARNSSGGMVPFSAFVTAKWINGPVQLIRYNGYPAMKIAGGAAPGRSTGEAMAE 838 ED+ NLY RN+ G MVP SAF W+ GPVQL+RYNGYP+++I+G AA G STG+AM E Sbjct: 781 EDIMNLYVRNTQGSMVPMSAFAKGHWVVGPVQLVRYNGYPSVRISGDAATGASTGDAMDE 840 Query: 839 MESFVAKLPPGFGFEWTGQSLEEKTSGNQAPALYALSLIAVFLVLAALYESTSIPLAVML 898 ME ++LP G GFEWTGQSL+EK+SG+QAPALYALSL+AVFLVLAALYES SIP AV+L Sbjct: 841 MEHLASRLPAGIGFEWTGQSLQEKSSGSQAPALYALSLLAVFLVLAALYESWSIPAAVIL 900 Query: 899 VVPLGILGALLGVTLRAMPNDVYFKVGMIAVVGLSAKNAILIIEFAKDLQAQGMGLIEAT 958 VVPLG+LGALLGVTLR MP+DVYFKVG+IAVVGLSAKNAILIIEFAKDLQAQG GLIEAT Sbjct: 901 VVPLGVLGALLGVTLRFMPDDVYFKVGLIAVVGLSAKNAILIIEFAKDLQAQGKGLIEAT 960 Query: 959 LEAVHLRFRPIIMTSLAFILGVLPLAIASGAGSASQRAIGTGVMGGMITATVLAVFLVPI 1018 LEAVHLRFRPIIMTS AFILGVLPLAIA+GA SASQRAIGTGVMGGMITATVLAV LVP+ Sbjct: 961 LEAVHLRFRPIIMTSFAFILGVLPLAIATGASSASQRAIGTGVMGGMITATVLAVVLVPV 1020 Query: 1019 FFVVVRKVFKGSERQRKFDAEHSP 1042 FFVVVR++FKGSERQR+ DA H P Sbjct: 1021 FFVVVRRIFKGSERQRRLDAAHLP 1044 >SMc02867 [V] COG0841 Cation/multidrug efflux pump Sme Sinorhizobium meliloti Length = 1048 Score = 1353 bits (3502), Expect = 0.0, Method: Compositional matrix adjust. Identities = 672/1034 (64%), Positives = 837/1034 (80%), Gaps = 3/1034 (0%) Query: 1 MGKFFIDRPVFAWVLAIFIMLAGALAITGLPVSQYPNIAPPTIVVTATYPGATAQTLDDS 60 M FFIDRP+FAWV+AIFIM+AG +AI LPVSQYP++APP I + YPGA++Q S Sbjct: 1 MPSFFIDRPIFAWVVAIFIMIAGIIAIPLLPVSQYPDVAPPQISINTNYPGASSQDTYQS 60 Query: 61 VTSLIEQEMNGADGLQYIESQSQANGQVQITVTFSPETNPDLAAVDVQNRLKRVEARLPA 120 VT LIE E+NG +GL Y ES + ++G V I TF P T+P A+VD+QNR++RVE RLP Sbjct: 61 VTRLIEDELNGVEGLLYFESSTSSSGSVSIDATFQPGTDPSQASVDIQNRVQRVEPRLPD 120 Query: 121 AVTQQGVQVTKSRSNFLLFIGLSSTDGKLDPVALGDYLSRNVLNEIKRVPGVGQAQLFGT 180 V QQGVQV ++ + FLL I L+STDG +D + LGDYLSRNVL+EI+RVPGVG+AQLF T Sbjct: 121 PVRQQGVQVDEAGAGFLLIISLTSTDGSMDAIGLGDYLSRNVLSEIQRVPGVGRAQLFAT 180 Query: 181 ERAMRIWIDPNKLIGLNLTPGDVTAAITAQNALVAGGTLGALPSPGTQQIAATVVVNGQL 240 ER+MR+W+DP+K++GLNLT DVTAAI AQNA +A G++GA P+P TQQ+ A VV+ GQL Sbjct: 181 ERSMRVWLDPDKMLGLNLTAADVTAAIQAQNAQIASGSIGAQPNPITQQVTAPVVIKGQL 240 Query: 241 TSPEQFGNIVLRANADGSTVRLRDVARVEMGGQSYDTSGRLDGKPSSFIGVQLSPTANAL 300 +SPE+FG IVLRANADGS VRLRDVAR+E+GG+SY S RL+G PS+ I VQLSP+ NA+ Sbjct: 241 SSPEEFGAIVLRANADGSAVRLRDVARLEIGGESYTFSTRLNGSPSAAIAVQLSPSGNAM 300 Query: 301 GTATAVHKKMEELAKYFPAGVKYTIPYDTSKFVKISIEEVVKTLIEAIVLVFLVMFLFLQ 360 T+ A+ +M+ELA++FP G++Y+IPYDTS FV +SIE+V+ TL+EA+ LVFLVMFLFLQ Sbjct: 301 STSAAIKARMDELAEFFPEGLEYSIPYDTSPFVAVSIEKVLHTLVEAVGLVFLVMFLFLQ 360 Query: 361 NIRYTIIPTIVVPVALLGTFATLLLFGFSINVLTMFGMVLAIGILVDDAIVVVENVERIM 420 N+RYTIIPTIVVPVALLGT A +L GFSINVLTMFGMVLAIGILVDDAI+VVENVERIM Sbjct: 361 NVRYTIIPTIVVPVALLGTCAVMLAMGFSINVLTMFGMVLAIGILVDDAIIVVENVERIM 420 Query: 421 SEEGLSPPEATRKAMGQISGALIGITLVLIAVFIPMAFFGGAVGAIYRQFSLSMVASMVF 480 SEEGL+P +ATRKAM QI+GA+IGITLVL +VFIPMAFF GAVG IYRQFSL+MV S++F Sbjct: 421 SEEGLTPKDATRKAMKQITGAVIGITLVLASVFIPMAFFPGAVGVIYRQFSLTMVVSILF 480 Query: 481 SVLMAFTLTPALCATILKPVEKGHHHEKKGFFGWFNRKFNSTASGYQGVISKMLNKAGRY 540 S L+A +LTPALCA+ LK V KGHHH K+GFFGWFNR F+ T+ GY + ++ + GR+ Sbjct: 481 SALLALSLTPALCASFLKQVPKGHHHAKRGFFGWFNRGFDRTSHGYTRAVGGIVRRTGRF 540 Query: 541 MIVYVVIVACVGLLYVRLPASFLPNEDQGYIITNVQLPPGASTARTLEVVKKIEQYYLKD 600 M++Y+ ++A +G +++LP+SFLP+EDQG++I +QLP A+ RT EV+++ E + ++ Sbjct: 541 MVIYLALLAGLGWAFLQLPSSFLPDEDQGFVIVMMQLPSEATANRTTEVIEQTETIFGQE 600 Query: 601 TAVEHAIAVLGYSFSGNGQNAALVFTPLKDWSERDKSQSADAIAGKAFGAFSQIKDAIVF 660 AV+ +A+ G+SF G+GQNA L F LKDWSERD SA +IAG+A A SQIKDAI F Sbjct: 601 KAVDTIVAINGFSFFGSGQNAGLAFVTLKDWSERDADNSAQSIAGRATMAMSQIKDAISF 660 Query: 661 PLNPPPIPELGNATGFTFRLQDRAGLGHAALVQARNQILGMAAQSKVLAGVRPEGLEDAP 720 L+PP I LG GF+FRLQDRAGLG AAL +AR+Q+L +A+QSKVL GVR EG+ DA Sbjct: 661 ALSPPAIQGLGTTGGFSFRLQDRAGLGQAALAEARDQLLDLASQSKVLTGVRFEGMPDAA 720 Query: 721 QLQLDIDRDKANALGVPFSTINSVLSTALGSSYVNDFPNQGRQQRVIVQADANQRLQPED 780 Q+ ++IDR+KAN GV F+ INS +ST LGSSYVNDFPN GR QRV VQAD +R+Q D Sbjct: 721 QVSVNIDREKANTFGVTFADINSTISTNLGSSYVNDFPNAGRMQRVTVQADETKRMQTAD 780 Query: 781 LTNLYARNSSGGMVPFSAFVTAKWINGPVQLIRYNGYPAMKIAGGAAPGRSTGEAMAEME 840 L NL RNS+GGMVP SAF +W+ P Q + YNGYPA++I+G AAPG S+G+A+AEME Sbjct: 781 LLNLNVRNSNGGMVPLSAFADVEWVKAPTQTVGYNGYPAVRISGEAAPGYSSGDAIAEME 840 Query: 841 SFVAKLPPGFGFEWTGQSLEEKTSGNQAPALYALSLIAVFLVLAALYESTSIPLAVMLVV 900 VA+LP GFG+EWTGQSL+E SG+QAP L ALS + VFL LAALYES SIP++V++VV Sbjct: 841 RLVAELPAGFGYEWTGQSLQEIQSGSQAPLLIALSCLLVFLCLAALYESWSIPVSVIMVV 900 Query: 901 PLGILGALLGVTLRAMPNDVYFKVGMIAVVGLSAKNAILIIEFAKDLQAQGMGLIEATLE 960 PLG++GA+L VT+R MPNDVYFKVG+IA++GLSAKNAILIIEFAK+L+ QG LI++TLE Sbjct: 901 PLGVIGAVLAVTMRDMPNDVYFKVGLIAIIGLSAKNAILIIEFAKELREQGKSLIDSTLE 960 Query: 961 AVHLRFRPIIMTSLAFILGVLPLAIASGAGSASQRAIGTGVMGGMITATVLAVFLVPIFF 1020 A HLRFRPI+MTSLAF LGVLPLAIA+GA S SQRAIGTGVMGGMI+ATVLA+F VP+FF Sbjct: 961 AAHLRFRPILMTSLAFTLGVLPLAIATGASSGSQRAIGTGVMGGMISATVLAIFFVPVFF 1020 Query: 1021 VVVRKVFKGSERQR 1034 V V K+F ER R Sbjct: 1021 VFVMKIF---ERGR 1031 >AGl3217 [V] COG0841 Cation/multidrug efflux pump Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 1044 Score = 1285 bits (3325), Expect = 0.0, Method: Compositional matrix adjust. Identities = 645/1013 (63%), Positives = 814/1013 (80%), Gaps = 1/1013 (0%) Query: 1 MGKFFIDRPVFAWVLAIFIMLAGALAITGLPVSQYPNIAPPTIVVTATYPGATAQTLDDS 60 M +FFIDRP+FAWV+AIFIMLAG LAI LP++QYPN+APP I + YPGA+ + + S Sbjct: 1 MARFFIDRPIFAWVVAIFIMLAGLLAIPMLPIAQYPNVAPPQISIGTNYPGASPEDIYQS 60 Query: 61 VTSLIEQEMNGADGLQYIESQSQANGQVQITVTFSPETNPDLAAVDVQNRLKRVEARLPA 120 VT IE+E+NG GL Y ES S+++G++ I VTF P TN A V+VQNR+ RVE RLP Sbjct: 61 VTRPIEEELNGVPGLIYFESTSESSGRISINVTFEPGTNIGEAQVEVQNRIARVEPRLPR 120 Query: 121 AVTQQGVQVTKSRSNFLLFIGLSSTDGKLDPVALGDYLSRNVLNEIKRVPGVGQAQLFGT 180 +VTQQG++V ++ ++FL+ + L+S DG D + LGDYLSRNVL E++RVPGVG AQLF T Sbjct: 121 SVTQQGLRVEQAGTSFLMMVALTSVDGNTDAIGLGDYLSRNVLGELRRVPGVGSAQLFAT 180 Query: 181 ERAMRIWIDPNKLIGLNLTPGDVTAAITAQNALVAGGTLGALPSPGTQQIAATVVVNGQL 240 +R+MRIW+DP+K++GL+LT DV AI AQN+ VA G +GA P+P QQI+ATV V GQL Sbjct: 181 QRSMRIWMDPDKMLGLSLTSDDVINAIQAQNSQVAAGRIGASPNPVGQQISATVNVQGQL 240 Query: 241 TSPEQFGNIVLRANADGSTVRLRDVARVEMGGQSYDTSGRLDGKPSSFIGVQLSPTANAL 300 TSPE+FG+IVLRAN DGS+VRLRDVARVE+GG+SY+ S RL+GKPS+ IGVQLSPTANA+ Sbjct: 241 TSPEEFGSIVLRANPDGSSVRLRDVARVEVGGESYNFSSRLNGKPSAAIGVQLSPTANAM 300 Query: 301 GTATAVHKKMEELAKYFPAGVKYTIPYDTSKFVKISIEEVVKTLIEAIVLVFLVMFLFLQ 360 T+ V MEEL++YFP G++Y IPYDTS FVKISIE+V+ TLIEA++LVF+VMF+FLQ Sbjct: 301 QTSEGVRATMEELSRYFPQGIEYEIPYDTSPFVKISIEKVIHTLIEAMILVFVVMFVFLQ 360 Query: 361 NIRYTIIPTIVVPVALLGTFATLLLFGFSINVLTMFGMVLAIGILVDDAIVVVENVERIM 420 NIRYTIIPT+VVPVALLGT A + + GFSINVLTMF MVLAIGILVDDAIVVVENVERIM Sbjct: 361 NIRYTIIPTLVVPVALLGTCAVMYVSGFSINVLTMFAMVLAIGILVDDAIVVVENVERIM 420 Query: 421 SEEGLSPPEATRKAMGQISGALIGITLVLIAVFIPMAFFGGAVGAIYRQFSLSMVASMVF 480 +EE LSP EATRKAMGQISGA+IGITLVL AVF+PMAFF GAVG IY+QFSL+MV S++F Sbjct: 421 AEEHLSPKEATRKAMGQISGAIIGITLVLTAVFVPMAFFPGAVGIIYQQFSLTMVVSILF 480 Query: 481 SVLMAFTLTPALCATILKPVEKGHHHEKKGFFGWFNRKFNSTASGYQGVISKMLNKAGRY 540 S +A +LTPALCA+ LKP++ G HHEKKGFFGWFNR F+ + Y + ++ ++GR+ Sbjct: 481 SGFLALSLTPALCASFLKPIKAG-HHEKKGFFGWFNRNFDKASHKYSSSVGGIIKRSGRF 539 Query: 541 MIVYVVIVACVGLLYVRLPASFLPNEDQGYIITNVQLPPGASTARTLEVVKKIEQYYLKD 600 MI+Y ++A +G Y++LP+SFLPNEDQGY+I ++Q P AST RTL+ +++IE+ ++++ Sbjct: 540 MIIYAALLAGLGWAYMQLPSSFLPNEDQGYLIVDIQAPAEASTERTLQSIQQIEKIFMEE 599 Query: 601 TAVEHAIAVLGYSFSGNGQNAALVFTPLKDWSERDKSQSADAIAGKAFGAFSQIKDAIVF 660 AVE IA+ G+SFSG+GQNA L F LKDWSER SA AI+ + G + DA+ F Sbjct: 600 PAVERVIAISGFSFSGSGQNAGLAFATLKDWSERGPEDSAAAISARINGKLWGLPDAMSF 659 Query: 661 PLNPPPIPELGNATGFTFRLQDRAGLGHAALVQARNQILGMAAQSKVLAGVRPEGLEDAP 720 L+PPPI LGN++GFTFRLQDR+G G AL A Q++ A QS VLAG+R EG+ DA Sbjct: 660 ALSPPPIQGLGNSSGFTFRLQDRSGAGQTALSAAGAQLMAAARQSPVLAGLRIEGMPDAA 719 Query: 721 QLQLDIDRDKANALGVPFSTINSVLSTALGSSYVNDFPNQGRQQRVIVQADANQRLQPED 780 Q+ L IDR+KAN GV FS IN+ +S +GSSYVNDFPN GR QRV VQA+ QR++ ED Sbjct: 720 QVNLIIDREKANTFGVTFSDINATISANMGSSYVNDFPNAGRMQRVTVQAEQGQRMKTED 779 Query: 781 LTNLYARNSSGGMVPFSAFVTAKWINGPVQLIRYNGYPAMKIAGGAAPGRSTGEAMAEME 840 L NL RN++GGMVP S+F T +W+ GP Q++ YNGYPA++++G +APG S+G+A+AEME Sbjct: 780 LLNLNVRNANGGMVPVSSFATVEWVRGPSQVVGYNGYPAIRVSGQSAPGYSSGDAIAEME 839 Query: 841 SFVAKLPPGFGFEWTGQSLEEKTSGNQAPALYALSLIAVFLVLAALYESTSIPLAVMLVV 900 +LP GFGFEWTGQSL+E SG+QAPAL LS++ VFL+LAALYES SIPL+VMLVV Sbjct: 840 RLARELPGGFGFEWTGQSLQEIQSGSQAPALIGLSVLFVFLLLAALYESWSIPLSVMLVV 899 Query: 901 PLGILGALLGVTLRAMPNDVYFKVGMIAVVGLSAKNAILIIEFAKDLQAQGMGLIEATLE 960 PLG++G++ V LR MPNDVYF VG++A++GLSAKNAILIIEFAKDL+A+G +AT+E Sbjct: 900 PLGVIGSVAAVMLRGMPNDVYFLVGLVAIIGLSAKNAILIIEFAKDLRAEGKSTYDATVE 959 Query: 961 AVHLRFRPIIMTSLAFILGVLPLAIASGAGSASQRAIGTGVMGGMITATVLAV 1013 A HLRFRPI+MTSLAF LGVLP+AIASGA +ASQ AIGTGV+GGMI+AT+LA+ Sbjct: 960 AAHLRFRPILMTSLAFSLGVLPMAIASGASAASQNAIGTGVLGGMISATILAI 1012 >STM0475 [V] COG0841 Cation/multidrug efflux pump Sty Salmonella typhimurium LT2 Length = 1049 Score = 1219 bits (3153), Expect = 0.0, Method: Compositional matrix adjust. Identities = 600/1019 (58%), Positives = 764/1019 (74%), Gaps = 6/1019 (0%) Query: 1 MGKFFIDRPVFAWVLAIFIMLAGALAITGLPVSQYPNIAPPTIVVTATYPGATAQTLDDS 60 M FFIDRP+FAWV+AI IMLAG LAI LPV+QYP IAPP + ++ATYPGA A+T+ D+ Sbjct: 1 MPNFFIDRPIFAWVIAIIIMLAGGLAILKLPVAQYPTIAPPAVTISATYPGADAKTVQDT 60 Query: 61 VTSLIEQEMNGADGLQYIESQSQANGQVQITVTFSPETNPDLAAVDVQNRLKRVEARLPA 120 VT +IEQ MNG D L Y+ S S + G VQIT+TF T+ D+A V VQN+L+ LP Sbjct: 61 VTQVIEQNMNGIDNLMYMSSNSDSTGTVQITLTFESGTDADIAQVQVQNKLQLAMPLLPQ 120 Query: 121 AVTQQGVQVTKSRSNFLLFIGLSSTDGKLDPVALGDYLSRNVLNEIKRVPGVGQAQLFGT 180 V QQGV V KS S+FL+ +G+ +TDG + + DY++ N+ + I R GVG QLFG+ Sbjct: 121 EVQQQGVSVEKSSSSFLMVVGVINTDGTMTQEDISDYVAANMKDPISRTSGVGDVQLFGS 180 Query: 181 ERAMRIWIDPNKLIGLNLTPGDVTAAITAQNALVAGGTLGALPSPGTQQIAATVVVNGQL 240 + AMRIW++P +L LTP DV AI AQNA VA G LG P QQ+ A+++ +L Sbjct: 181 QYAMRIWMNPTELTKYQLTPVDVINAIKAQNAQVAAGQLGGTPPVKGQQLNASIIAQTRL 240 Query: 241 TSPEQFGNIVLRANADGSTVRLRDVARVEMGGQSYDTSGRLDGKPSSFIGVQLSPTANAL 300 TS ++FG I+L+ N DGS VRLRDVA++E+GG++YD + +G+P+S +G++L+ ANAL Sbjct: 241 TSTDEFGKILLKVNQDGSQVRLRDVAKIELGGENYDVIAKFNGQPASGLGIKLATGANAL 300 Query: 301 GTATAVHKKMEELAKYFPAGVKYTIPYDTSKFVKISIEEVVKTLIEAIVLVFLVMFLFLQ 360 TATA+ +++++ +FP G+K PYDT+ FVKISI EVVKTL+EAI+LVFLVM+LFLQ Sbjct: 301 DTATAIRAELKKMEPFFPPGMKIVYPYDTTPFVKISIHEVVKTLVEAIILVFLVMYLFLQ 360 Query: 361 NIRYTIIPTIVVPVALLGTFATLLLFGFSINVLTMFGMVLAIGILVDDAIVVVENVERIM 420 N R T+IPTI VPV LLGTFA L FGFSIN LTMFGMVLAIG+LVDDAIVVVENVER+M Sbjct: 361 NFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFGMVLAIGLLVDDAIVVVENVERVM 420 Query: 421 SEEGLSPPEATRKAMGQISGALIGITLVLIAVFIPMAFFGGAVGAIYRQFSLSMVASMVF 480 +EEGL P EATRK+MGQI GAL+GI +VL AVFIPMAFFGG+ GAIYRQFS+++V++M Sbjct: 421 TEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFIPMAFFGGSTGAIYRQFSITIVSAMAL 480 Query: 481 SVLMAFTLTPALCATILKPVEKGHHHE-KKGFFGWFNRKFNSTASGYQGVISKMLNKAGR 539 SVL+A LTPALCAT+LKPV KG H E KKGFFGWFNR F+ + Y + +L GR Sbjct: 481 SVLVALILTPALCATMLKPVAKGDHGEGKKGFFGWFNRLFDKSTHHYTDSVGNILRSTGR 540 Query: 540 YMIVYVVIVACVGLLYVRLPASFLPNEDQGYIITNVQLPPGASTARTLEVVKKIEQYYL- 598 Y+++Y++IV + L+VRLP+SFLP+EDQG +T VQLP GA+ RT +V+ ++ YYL Sbjct: 541 YLLLYLIIVVGMAYLFVRLPSSFLPDEDQGVFLTMVQLPAGATQERTQKVLDEVTDYYLN 600 Query: 599 KDTA-VEHAIAVLGYSFSGNGQNAALVFTPLKDWSER-DKSQSADAIAGKAFGAFSQIKD 656 K+ A VE AV G+ F+G GQN + F LKDW++R + +AI +A AFSQIKD Sbjct: 601 KEKANVESVFAVNGFGFAGRGQNTGIAFVSLKDWADRPGEKNKVEAITQRATAAFSQIKD 660 Query: 657 AIVFPLNPPPIPELGNATGFTFRLQDRAGLGHAALVQARNQILGMAAQ-SKVLAGVRPEG 715 A+VF N P I ELG ATGF F L D+AGLGH L QARNQ+ G A+ +L GVRP G Sbjct: 661 AMVFAFNLPAIVELGTATGFDFELIDQAGLGHEKLTQARNQLFGEVAKYPDLLVGVRPNG 720 Query: 716 LEDAPQLQLDIDRDKANALGVPFSTINSVLSTALGSSYVNDFPNQGRQQRVIVQADANQR 775 LED PQ ++DID++KA ALGV S IN+ L A G SYVNDF ++GR ++V V ++A R Sbjct: 721 LEDTPQFKIDIDQEKAQALGVSISDINTTLGAAWGGSYVNDFIDRGRVKKVYVMSEAKYR 780 Query: 776 LQPEDLTNLYARNSSGGMVPFSAFVTAKWINGPVQLIRYNGYPAMKIAGGAAPGRSTGEA 835 + P+D+ + Y R S G MVPFSAF +++W G +L RYNG P+M+I G AAPG+STGEA Sbjct: 781 MLPDDINDWYVRGSDGQMVPFSAFSSSRWEYGSPRLERYNGLPSMEILGQAAPGKSTGEA 840 Query: 836 MAEMESFVAKLPPGFGFEWTGQSLEEKTSGNQAPALYALSLIAVFLVLAALYESTSIPLA 895 MA ME +KLP G G++WTG S +E+ SGNQAPALYA+SLI VFL LAALYES SIP + Sbjct: 841 MAMMEELASKLPSGIGYDWTGMSYQERLSGNQAPALYAISLIVVFLCLAALYESWSIPFS 900 Query: 896 VMLVVPLGILGALLGVTLRAMPNDVYFKVGMIAVVGLSAKNAILIIEFAKDL-QAQGMGL 954 VMLVVPLG++GALL T R + NDVYF+VG++ +GLSAKNAILI+EFAKDL +G GL Sbjct: 901 VMLVVPLGVIGALLAATFRGLTNDVYFQVGLLTTIGLSAKNAILIVEFAKDLMDKEGKGL 960 Query: 955 IEATLEAVHLRFRPIIMTSLAFILGVLPLAIASGAGSASQRAIGTGVMGGMITATVLAV 1013 +EATLEAV +R RPI+MTSLAF+LGV+PL I+SGAGS +Q A+GTGV+GGM+TATVLA+ Sbjct: 961 VEATLEAVRMRLRPILMTSLAFMLGVMPLVISSGAGSGAQNAVGTGVLGGMVTATVLAI 1019 >acrB [V] COG0841 Cation/multidrug efflux pump Eco Escherichia coli K12 Length = 1049 Score = 1206 bits (3120), Expect = 0.0, Method: Compositional matrix adjust. Identities = 601/1051 (57%), Positives = 771/1051 (73%), Gaps = 10/1051 (0%) Query: 1 MGKFFIDRPVFAWVLAIFIMLAGALAITGLPVSQYPNIAPPTIVVTATYPGATAQTLDDS 60 M FFIDRP+FAWV+AI IMLAG LAI LPV+QYP IAPP + ++A+YPGA A+T+ D+ Sbjct: 1 MPNFFIDRPIFAWVIAIIIMLAGGLAILKLPVAQYPTIAPPAVTISASYPGADAKTVQDT 60 Query: 61 VTSLIEQEMNGADGLQYIESQSQANGQVQITVTFSPETNPDLAAVDVQNRLKRVEARLPA 120 VT +IEQ MNG D L Y+ S S + G VQIT+TF T+ D+A V VQN+L+ LP Sbjct: 61 VTQVIEQNMNGIDNLMYMSSNSDSTGTVQITLTFESGTDADIAQVQVQNKLQLAMPLLPQ 120 Query: 121 AVTQQGVQVTKSRSNFLLFIGLSSTDGKLDPVALGDYLSRNVLNEIKRVPGVGQAQLFGT 180 V QQGV V KS S+FL+ +G+ +TDG + + DY++ N+ + I R GVG QLFG+ Sbjct: 121 EVQQQGVSVEKSSSSFLMVVGVINTDGTMTQEDISDYVAANMKDAISRTSGVGDVQLFGS 180 Query: 181 ERAMRIWIDPNKLIGLNLTPGDVTAAITAQNALVAGGTLGALPSPGTQQIAATVVVNGQL 240 + AMRIW++PN+L LTP DV AI AQNA VA G LG P QQ+ A+++ +L Sbjct: 181 QYAMRIWMNPNELNKFQLTPVDVITAIKAQNAQVAAGQLGGTPPVKGQQLNASIIAQTRL 240 Query: 241 TSPEQFGNIVLRANADGSTVRLRDVARVEMGGQSYDTSGRLDGKPSSFIGVQLSPTANAL 300 TS E+FG I+L+ N DGS V LRDVA++E+GG++YD +G+P+S +G++L+ ANAL Sbjct: 241 TSTEEFGKILLKVNQDGSRVLLRDVAKIELGGENYDIIAEFNGQPASGLGIKLATGANAL 300 Query: 301 GTATAVHKKMEELAKYFPAGVKYTIPYDTSKFVKISIEEVVKTLIEAIVLVFLVMFLFLQ 360 TA A+ ++ ++ +FP+G+K PYDT+ FVKISI EVVKTL+EAI+LVFLVM+LFLQ Sbjct: 301 DTAAAIRAELAKMEPFFPSGLKIVYPYDTTPFVKISIHEVVKTLVEAIILVFLVMYLFLQ 360 Query: 361 NIRYTIIPTIVVPVALLGTFATLLLFGFSINVLTMFGMVLAIGILVDDAIVVVENVERIM 420 N R T+IPTI VPV LLGTFA L FGFSIN LTMFGMVLAIG+LVDDAIVVVENVER+M Sbjct: 361 NFRATLIPTIAVPVVLLGTFAVLAAFGFSINTLTMFGMVLAIGLLVDDAIVVVENVERVM 420 Query: 421 SEEGLSPPEATRKAMGQISGALIGITLVLIAVFIPMAFFGGAVGAIYRQFSLSMVASMVF 480 +EEGL P EATRK+MGQI GAL+GI +VL AVF+PMAFFGG+ GAIYRQFS+++V++M Sbjct: 421 AEEGLPPKEATRKSMGQIQGALVGIAMVLSAVFVPMAFFGGSTGAIYRQFSITIVSAMAL 480 Query: 481 SVLMAFTLTPALCATILKPVEKGHHHE-KKGFFGWFNRKFNSTASGYQGVISKMLNKAGR 539 SVL+A LTPALCAT+LKP+ KG H E KKGFFGWFNR F + Y + +L GR Sbjct: 481 SVLVALILTPALCATMLKPIAKGDHGEGKKGFFGWFNRMFEKSTHHYTDSVGGILRSTGR 540 Query: 540 YMIVYVVIVACVGLLYVRLPASFLPNEDQGYIITNVQLPPGASTARTLEVVKKIEQYYL- 598 Y+++Y++IV + L+VRLP+SFLP+EDQG +T VQLP GA+ RT +V+ ++ YYL Sbjct: 541 YLVLYLIIVVGMAYLFVRLPSSFLPDEDQGVFMTMVQLPAGATQERTQKVLNEVTHYYLT 600 Query: 599 -KDTAVEHAIAVLGYSFSGNGQNAALVFTPLKDWSER-DKSQSADAIAGKAFGAFSQIKD 656 + VE AV G+ F+G GQN + F LKDW++R + +AI +A AFSQIKD Sbjct: 601 KEKNNVESVFAVNGFGFAGRGQNTGIAFVSLKDWADRPGEENKVEAITMRATRAFSQIKD 660 Query: 657 AIVFPLNPPPIPELGNATGFTFRLQDRAGLGHAALVQARNQILGMAAQS-KVLAGVRPEG 715 A+VF N P I ELG ATGF F L D+AGLGH L QARNQ+L AA+ +L VRP G Sbjct: 661 AMVFAFNLPAIVELGTATGFDFELIDQAGLGHEKLTQARNQLLAEAAKHPDMLTSVRPNG 720 Query: 716 LEDAPQLQLDIDRDKANALGVPFSTINSVLSTALGSSYVNDFPNQGRQQRVIVQADANQR 775 LED PQ ++DID++KA ALGV + IN+ L A G SYVNDF ++GR ++V V ++A R Sbjct: 721 LEDTPQFKIDIDQEKAQALGVSINDINTTLGAAWGGSYVNDFIDRGRVKKVYVMSEAKYR 780 Query: 776 LQPEDLTNLYARNSSGGMVPFSAFVTAKWINGPVQLIRYNGYPAMKIAGGAAPGRSTGEA 835 + P+D+ + Y R + G MVPFSAF +++W G +L RYNG P+M+I G AAPG+STGEA Sbjct: 781 MLPDDIGDWYVRAADGQMVPFSAFSSSRWEYGSPRLERYNGLPSMEILGQAAPGKSTGEA 840 Query: 836 MAEMESFVAKLPPGFGFEWTGQSLEEKTSGNQAPALYALSLIAVFLVLAALYESTSIPLA 895 M ME +KLP G G++WTG S +E+ SGNQAP+LYA+SLI VFL LAALYES SIP + Sbjct: 841 MELMEQLASKLPTGVGYDWTGMSYQERLSGNQAPSLYAISLIVVFLCLAALYESWSIPFS 900 Query: 896 VMLVVPLGILGALLGVTLRAMPNDVYFKVGMIAVVGLSAKNAILIIEFAKDL-QAQGMGL 954 VMLVVPLG++GALL T R + NDVYF+VG++ +GLSAKNAILI+EFAKDL +G GL Sbjct: 901 VMLVVPLGVIGALLAATFRGLTNDVYFQVGLLTTIGLSAKNAILIVEFAKDLMDKEGKGL 960 Query: 955 IEATLEAVHLRFRPIIMTSLAFILGVLPLAIASGAGSASQRAIGTGVMGGMITATVLAVF 1014 IEATL+AV +R RPI+MTSLAFILGV+PL I++GAGS +Q A+GTGVMGGM+TATVLA+F Sbjct: 961 IEATLDAVRMRLRPILMTSLAFILGVMPLVISTGAGSGAQNAVGTGVMGGMVTATVLAIF 1020 Query: 1015 LVPIFFVVVRKVFKGSERQRKFDAEHSPKID 1045 V V V + ++ D EHS +D Sbjct: 1021 FV----PVFFVVVRRRFSRKNEDIEHSHTVD 1047