BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.0415.p (410 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PA1993 [GEPR] COG0477 Permeases of the major facilitator superfa... 413 e-115 yhhS [GEPR] COG0477 Permeases of the major facilitator superfami... 333 3e-91 ZyhhS [GEPR] COG0477 Permeases of the major facilitator superfam... 329 6e-90 ECs4322 [GEPR] COG0477 Permeases of the major facilitator superf... 329 6e-90 STM3581 [GEPR] COG0477 Permeases of the major facilitator superf... 328 1e-89 >PA1993 [GEPR] COG0477 Permeases of the major facilitator superfamily Pae Pseudomonas aeruginosa Length = 402 Score = 413 bits (1061), Expect = e-115, Method: Compositional matrix adjust. Identities = 226/395 (57%), Positives = 290/395 (73%), Gaps = 1/395 (0%) Query: 12 PTPAPARALPPAKVTRQIIATAFFTFLVYLAIGIPLAVLPGYIHLDLGYSSVMAGLGISV 71 PTP PA+ VT QI++ FTF+ YL IGIPLAVLPGY+H DLGY SV+AGL IS+ Sbjct: 7 PTP-PAQDSARQNVTLQIVSVVMFTFIGYLTIGIPLAVLPGYVHDDLGYGSVLAGLVISL 65 Query: 72 QYFATFVSRANAGRMIDTVGAKQTVMRGMLLCAASGALLLCSALAQPLPFLSLVLLLVSR 131 QY AT ++R AGR+ID +G K+ V+ GM AASG +L S Q P LSL LLV R Sbjct: 66 QYLATLLARPYAGRVIDGLGPKRAVLYGMAGSAASGLFMLLSVAIQGWPALSLASLLVGR 125 Query: 132 AFLGLGESLVGTGAIMWGVGRVGSENTAKMISWNGIATYSALAIGAPLGVVLDRSLGFGM 191 LG ESLVG+ AI WG+GRVG+ +TAK+ISWNGIA+Y A+A+GAPLGV+L + LG Sbjct: 126 LVLGAAESLVGSAAIGWGIGRVGAPHTAKVISWNGIASYGAIALGAPLGVLLVQWLGLWS 185 Query: 192 IGLAGMLLTALGYVLARGGPVTPVVQGEQLSFKLVLRKVFAYGMGLAFGTIGFGSIATFI 251 +G + +LL ALG+ LA P+V GE+L F VL +V +GMGLA G IGFG+IATFI Sbjct: 186 MGASIVLLGALGFALAWPKLPAPLVHGERLPFHHVLGRVTPHGMGLALGAIGFGTIATFI 245 Query: 252 TLYYADLHWSGAAFALTAFSSAFVGARLLFANAINRFGGYRVAVVSFITEAIGLLLLWSA 311 TLYYA W+ A L+AF F+GARLLFAN+INR GG+RVA++ E++GLLLLWSA Sbjct: 246 TLYYASRGWANAVLCLSAFGGCFIGARLLFANSINRLGGFRVAIICLGVESLGLLLLWSA 305 Query: 312 TTPELALLGAALAGFGFALVFPSLGVEAVNLVTPANRGAALAAYSVFLDLALGVTGPLAG 371 P + L GAAL GFGF+LVFP+ GVEAVNLV +NRGAAL AYS+F+DL+LG+TGPL G Sbjct: 306 PNPWVGLAGAALTGFGFSLVFPAFGVEAVNLVPASNRGAALGAYSLFVDLSLGITGPLVG 365 Query: 372 AIAGQLGYAQVFLFAAIAAIGGVALSLSLYRSAQQ 406 +A G+ +FLFA +A++GG+AL+++L+R +++ Sbjct: 366 FVANLFGFRSMFLFACLASLGGLALAVALHRRSRR 400 >yhhS [GEPR] COG0477 Permeases of the major facilitator superfamily Eco Escherichia coli K12 Length = 419 Score = 333 bits (855), Expect = 3e-91, Method: Compositional matrix adjust. Identities = 196/399 (49%), Positives = 256/399 (64%), Gaps = 4/399 (1%) Query: 12 PTPAPARALPPAKVTRQIIATAFFTFLVYLAIGIPLAVLPGYIHLDLGYSSVMAGLGISV 71 P P AL ++ +I++ F F YL IG+PLAVLPGY+H +G+S+ AGL IS+ Sbjct: 16 PEPVAEPALNGLRLNLRIVSIVMFNFASYLTIGLPLAVLPGYVHDVMGFSAFWAGLVISL 75 Query: 72 QYFATFVSRANAGRMIDTVGAKQTVMRGMLLCAASGALLLCSALAQPLPFLSLVLLLVSR 131 QYFAT +SR +AGR D++G K+ V+ G+ C SG L + L LP +SL+LL + R Sbjct: 76 QYFATLLSRPHAGRYADSLGPKKIVVFGLCGCFLSGLGYLTAGLTASLPVISLLLLCLGR 135 Query: 132 AFLGLGESLVGTGAIMWGVGRVGSENTAKMISWNGIATYSALAIGAPLGVVLDRSLGFGM 191 LG+G+S GTG+ +WGVG VGS + ++ISWNGI TY A+A+GAPLGVV G Sbjct: 136 VILGIGQSFAGTGSTLWGVGVVGSLHIGRVISWNGIVTYGAMAMGAPLGVVFYHWGGLQA 195 Query: 192 IGLAGMLLTALGYVLARGGPVTPVVQGEQLSFKLVLRKVFAYGMGLAFGTIGFGSIATFI 251 + L M + + +LA P +G+ L F+ VL +V+ YGM LA + GFG IATFI Sbjct: 196 LALIIMGVALVAILLAIPRPTVKASKGKPLPFRAVLGRVWLYGMALALASAGFGVIATFI 255 Query: 252 TLYYADLHWSGAAFALTAFSSAFVGARLLFANAINRFGGYRVAVVSFITEAIGLLLLWSA 311 TL+Y W GAAFALT FS AFVG RLLF N INR GG VA++ F E IGLLL+ A Sbjct: 256 TLFYDAKGWDGAAFALTLFSCAFVGTRLLFPNGINRIGGLNVAMICFSVEIIGLLLVGVA 315 Query: 312 TTPELALLGAALAGFGFALVFPSLGVEAVNLVTPANRGAALAAYSVFLDLALGVTGPLAG 371 T P +A +G LAG GF+LVFP+LGV AV V N+GAALA Y+VF+DL+LGVTGPLAG Sbjct: 316 TMPWMAKIGVLLAGAGFSLVFPALGVVAVKAVPQQNQGAALATYTVFMDLSLGVTGPLAG 375 Query: 372 AIAGQLGYAQVFLFAAIAAIGGVALSLSLYRSAQQRDKS 410 + G ++L AA G VA++L L ++R Sbjct: 376 LVMSWAGVPVIYL----AAAGLVAIALLLTWRLKKRPPE 410 >ZyhhS [GEPR] COG0477 Permeases of the major facilitator superfamily EcZ Escherichia coli O157:H7 EDL933 Length = 419 Score = 329 bits (844), Expect = 6e-90, Method: Compositional matrix adjust. Identities = 195/399 (48%), Positives = 254/399 (63%), Gaps = 4/399 (1%) Query: 12 PTPAPARALPPAKVTRQIIATAFFTFLVYLAIGIPLAVLPGYIHLDLGYSSVMAGLGISV 71 P P AL ++ +I++ F F YL IG+PLAVLPGY+H +G+S+ AGL IS+ Sbjct: 16 PEPVAEPALNGLRLNLRILSIVMFNFASYLTIGLPLAVLPGYVHDVMGFSAFWAGLVISL 75 Query: 72 QYFATFVSRANAGRMIDTVGAKQTVMRGMLLCAASGALLLCSALAQPLPFLSLVLLLVSR 131 QYFAT +SR +AGR D +G K+ V+ G+ C SG L + L LP +SL+LL + R Sbjct: 76 QYFATLLSRPHAGRYADLLGPKKIVVFGLCGCFLSGLGYLTAGLTASLPVISLLLLCLGR 135 Query: 132 AFLGLGESLVGTGAIMWGVGRVGSENTAKMISWNGIATYSALAIGAPLGVVLDRSLGFGM 191 LG+G+S GTG+ +WGVG VGS + ++ISWN I TY A+A+GAPLGVV G Sbjct: 136 VILGIGQSFAGTGSTLWGVGVVGSLHIGRVISWNDIVTYGAMAMGAPLGVVFYHWGGLQA 195 Query: 192 IGLAGMLLTALGYVLARGGPVTPVVQGEQLSFKLVLRKVFAYGMGLAFGTIGFGSIATFI 251 + L M + + +LA P +G+ L F+ VL +V+ YGM LA + GFG IATFI Sbjct: 196 LALIIMGVALVAILLAIPRPTVKASKGKPLPFRAVLGRVWLYGMALALASAGFGVIATFI 255 Query: 252 TLYYADLHWSGAAFALTAFSSAFVGARLLFANAINRFGGYRVAVVSFITEAIGLLLLWSA 311 TL+Y W GAAFALT FS AFVG RLLF N INR GG VA++ F E IGLLL+ A Sbjct: 256 TLFYDVKGWDGAAFALTLFSCAFVGTRLLFPNGINRIGGLNVAMICFSVEIIGLLLVGVA 315 Query: 312 TTPELALLGAALAGFGFALVFPSLGVEAVNLVTPANRGAALAAYSVFLDLALGVTGPLAG 371 T P +A +G LAG GF+LVFP+LGV AV V N+GAALA Y+VF+DL+LGVTGPLAG Sbjct: 316 TMPWMAKIGVLLAGAGFSLVFPALGVVAVKAVPQQNQGAALATYTVFMDLSLGVTGPLAG 375 Query: 372 AIAGQLGYAQVFLFAAIAAIGGVALSLSLYRSAQQRDKS 410 + G ++L AA G VA++L L ++R Sbjct: 376 LVMSWAGVPVIYL----AAAGLVAIALLLTWRLKKRPPE 410 >ECs4322 [GEPR] COG0477 Permeases of the major facilitator superfamily Ecs Escherichia coli O157:H7 Length = 419 Score = 329 bits (844), Expect = 6e-90, Method: Compositional matrix adjust. Identities = 195/399 (48%), Positives = 254/399 (63%), Gaps = 4/399 (1%) Query: 12 PTPAPARALPPAKVTRQIIATAFFTFLVYLAIGIPLAVLPGYIHLDLGYSSVMAGLGISV 71 P P AL ++ +I++ F F YL IG+PLAVLPGY+H +G+S+ AGL IS+ Sbjct: 16 PEPVAEPALNGLRLNLRILSIVMFNFASYLTIGLPLAVLPGYVHDVMGFSAFWAGLVISL 75 Query: 72 QYFATFVSRANAGRMIDTVGAKQTVMRGMLLCAASGALLLCSALAQPLPFLSLVLLLVSR 131 QYFAT +SR +AGR D +G K+ V+ G+ C SG L + L LP +SL+LL + R Sbjct: 76 QYFATLLSRPHAGRYADLLGPKKIVVFGLCGCFLSGLGYLTAGLTASLPVISLLLLCLGR 135 Query: 132 AFLGLGESLVGTGAIMWGVGRVGSENTAKMISWNGIATYSALAIGAPLGVVLDRSLGFGM 191 LG+G+S GTG+ +WGVG VGS + ++ISWN I TY A+A+GAPLGVV G Sbjct: 136 VILGIGQSFAGTGSTLWGVGVVGSLHIGRVISWNDIVTYGAMAMGAPLGVVFYHWGGLQA 195 Query: 192 IGLAGMLLTALGYVLARGGPVTPVVQGEQLSFKLVLRKVFAYGMGLAFGTIGFGSIATFI 251 + L M + + +LA P +G+ L F+ VL +V+ YGM LA + GFG IATFI Sbjct: 196 LALIIMGVALVAILLAIPRPTVKASKGKPLPFRAVLGRVWLYGMALALASAGFGVIATFI 255 Query: 252 TLYYADLHWSGAAFALTAFSSAFVGARLLFANAINRFGGYRVAVVSFITEAIGLLLLWSA 311 TL+Y W GAAFALT FS AFVG RLLF N INR GG VA++ F E IGLLL+ A Sbjct: 256 TLFYDVKGWDGAAFALTLFSCAFVGTRLLFPNGINRIGGLNVAMICFSVEIIGLLLVGVA 315 Query: 312 TTPELALLGAALAGFGFALVFPSLGVEAVNLVTPANRGAALAAYSVFLDLALGVTGPLAG 371 T P +A +G LAG GF+LVFP+LGV AV V N+GAALA Y+VF+DL+LGVTGPLAG Sbjct: 316 TMPWMAKIGVLLAGAGFSLVFPALGVVAVKAVPQQNQGAALATYTVFMDLSLGVTGPLAG 375 Query: 372 AIAGQLGYAQVFLFAAIAAIGGVALSLSLYRSAQQRDKS 410 + G ++L AA G VA++L L ++R Sbjct: 376 LVMSWAGVPVIYL----AAAGLVAIALLLTWRLKKRPPE 410 >STM3581 [GEPR] COG0477 Permeases of the major facilitator superfamily Sty Salmonella typhimurium LT2 Length = 419 Score = 328 bits (842), Expect = 1e-89, Method: Compositional matrix adjust. Identities = 197/418 (47%), Positives = 261/418 (62%), Gaps = 17/418 (4%) Query: 1 MSDDSCSPRSA---PTPAPARALPPAKVTRQIIATAFFTFLVYLAIGIPLAVLPGYIHLD 57 + +C + P P AL ++ +I++ F F YL IG+PLAVLPGY+H Sbjct: 2 IEKKTCCKNAVILMPEPVAEPALNGLRLNLRIVSIVMFNFASYLTIGLPLAVLPGYVHDA 61 Query: 58 LGYSSVMAGLGISVQYFATFVSRANAGRMIDTVGAKQTVMRGMLLCAASGALLLCSALAQ 117 +G+S+ AGL IS+QYFAT +SR +AGR D +G K+ V+ G+ C SG L + +A Sbjct: 62 MGFSAFWAGLIISLQYFATLLSRPHAGRYADVLGPKKIVVFGLCGCFLSGLGYLLADIAS 121 Query: 118 PLPFLSLVLLLVSRAFLGLGESLVGTGAIMWGVGRVGSENTAKMISWNGIATYSALAIGA 177 P +SL+LL + R LG+G+S GTG+ +WGVG VGS + ++ISWNGI TY A+A+GA Sbjct: 122 AWPMISLLLLGLGRVILGIGQSFAGTGSTLWGVGVVGSLHIGRVISWNGIVTYGAMAMGA 181 Query: 178 PLGVVLDRSLGFGMIGLAGMLLTALGYVLARGG-----PVTPVVQGEQLSFKLVLRKVFA 232 PLGV L + GL G+ LT +G L P +G+ L F+ VL +V+ Sbjct: 182 PLGV-----LCYAWGGLQGLALTVMGVALLAVLLALPRPSVKANKGKPLPFRAVLGRVWL 236 Query: 233 YGMGLAFGTIGFGSIATFITLYYADLHWSGAAFALTAFSSAFVGARLLFANAINRFGGYR 292 YGM LA + GFG IATFITL+Y W GAAFALT FS AFVG RLLF N INR GG Sbjct: 237 YGMALALASAGFGVIATFITLFYDAKGWDGAAFALTLFSVAFVGTRLLFPNGINRLGGLN 296 Query: 293 VAVVSFITEAIGLLLLWSATTPELALLGAALAGFGFALVFPSLGVEAVNLVTPANRGAAL 352 VA++ F E IGLLL+ +A P +A +G L G GF+LVFP+LGV AV V P N+GAAL Sbjct: 297 VAMICFGVEIIGLLLVGTAAMPWMAKIGVLLTGMGFSLVFPALGVVAVKAVPPQNQGAAL 356 Query: 353 AAYSVFLDLALGVTGPLAGAIAGQLGYAQVFLFAAIAAIGGVALSLSLYRSAQQRDKS 410 A Y+VF+D++LGVTGPLAG + G ++L AA G VA++L L ++R S Sbjct: 357 ATYTVFMDMSLGVTGPLAGLVMTWAGVPVIYL----AAAGLVAMALLLTWRLKKRPPS 410