BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.0383.p (515 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PA0667 [M] COG0739 Membrane proteins related to metalloendopepti... 263 7e-70 XF0167 [M] COG0739 Membrane proteins related to metalloendopepti... 251 3e-66 NMA2172 [M] COG0739 Membrane proteins related to metalloendopept... 228 3e-59 NMB0315 [M] COG0739 Membrane proteins related to metalloendopept... 227 4e-59 RC0557 [M] COG0739 Membrane proteins related to metalloendopepti... 200 6e-51 >PA0667 [M] COG0739 Membrane proteins related to metalloendopeptidases Pae Pseudomonas aeruginosa Length = 447 Score = 263 bits (672), Expect = 7e-70, Method: Compositional matrix adjust. Identities = 146/354 (41%), Positives = 201/354 (56%), Gaps = 8/354 (2%) Query: 146 VRSGDTLASLLNRLGVDDDEATAFIKSDTLARSVMQLRAGKRVVAQTDDNGELVKLSATL 205 V SGDTL+++ + G+ + S A+ L+ G+ V + D GEL L Sbjct: 87 VASGDTLSTVFTKAGLSTSAMHDMLTSSKDAKRFTHLKVGQEVKLKLDPKGELQALRVKQ 146 Query: 206 DDGSDTPKNLVISRQDGKLTAQAQPAVLERRVEMRAGIIYSSLFAATDAAQIPDAVAMQL 265 + + + + + D + + + A ++ G I SSLF A A +P + L Sbjct: 147 SE----LETIGLDKTDKGYSFKREKAQIDLHTAYAHGRITSSLFVAGRNAGLPYNLVTSL 202 Query: 266 VDMFATNINFASDLRRGDRFNVVYETYYQNGDLVRTGRVLAGEFDNAGNRYQAVWFSDPA 325 ++F +I+FA DLR GD F+V+YE + NG V TG +LA F N G Y AV +++ Sbjct: 203 SNIFGYDIDFALDLREGDEFDVIYEQHKVNGKQVATGNILAARFVNRGKTYTAVRYTN-- 260 Query: 326 SKTGGGGYYAFDGKSLKKAFLKSPLAFTRISSGFSM-RLHPILGKWKQHTGVDFAAPTGT 384 K G YY DG S++KAF+++P+ F RISS FS+ R HPIL K + H GVD+AAP GT Sbjct: 261 -KQGNTSYYRADGSSMRKAFIRTPVDFARISSRFSLGRRHPILNKIRAHKGVDYAAPIGT 319 Query: 385 PIHAAADGVIDFVGQQNGYGNIVVIKHWSGYSTAYGHMSRFAPKLKKGMKVSQNDVIGFV 444 PI A DG I G++ GYGN VVI+H Y T YGHMSRFA ++ G V Q +IG+V Sbjct: 320 PIKATGDGKILEAGRKGGYGNAVVIQHGQRYRTIYGHMSRFAKGIRAGTSVKQGQIIGYV 379 Query: 445 GMTGWATGPHLHYEFRVNNQPRNPLSVDVPNNQALTGPQLQRFRAVAADMQHRM 498 GMTG ATGPHLHYEF++N + +PLS +P L G +RF A M RM Sbjct: 380 GMTGLATGPHLHYEFQINGRHVDPLSAKLPMADPLGGADRKRFMAQTQPMIARM 433 >XF0167 [M] COG0739 Membrane proteins related to metalloendopeptidases Xfa Xylella fastidiosa 9a5c Length = 417 Score = 251 bits (641), Expect = 3e-66, Method: Compositional matrix adjust. Identities = 134/350 (38%), Positives = 201/350 (57%), Gaps = 10/350 (2%) Query: 146 VRSGDTLASLLNRLGVDDDEATAFIKSDTLARSVMQLRAGKRVVAQTDDNGELVKLSATL 205 ++ G TL+S+ N L + ++ + L + + +L G + ++G+L + Sbjct: 48 IKPGQTLSSIFNELKLSSNDMERVLNYADLRKLLTRLSPGDEISFDIPNDGQLRGMRFNR 107 Query: 206 DDGSDTPKNLVISRQDGKLTAQAQPAVLERRVEMRAGIIYSSLFAATDAAQIPDAVAMQL 265 D+ + ++ D + Q R + +G I SSL+ A A + A + L Sbjct: 108 DE----KHRVELTLDDNTIHQQVSERQTSTRTVIASGEIKSSLWIAAREAGLSPADVITL 163 Query: 266 VD-MFATNINFASDLRRGDRFNVVYETYYQNGDLVRTGRVLAGEFDNAGNRYQAVWFSDP 324 D +F +I+F DL+ GDRF+VV + ++ G+ + ++LA F+ G Y + F Sbjct: 164 TDEIFKYDIDFDKDLQTGDRFSVVMDETWREGERLPDAKILAATFNTGGKIYSGMRFM-- 221 Query: 325 ASKTGGGGYYAFDGKSLKKAFLKSPLAFTRISSGFSMRLHPILGKWKQHTGVDFAAPTGT 384 + G Y+ DG+ LKK+F++ P+++ R+SS F +R HPILG + H GVD+AA TGT Sbjct: 222 --RDGKVEYFDKDGRPLKKSFIRMPISYARLSSTFGLRRHPILGTMRMHKGVDYAAATGT 279 Query: 385 PIHAAADGVIDFVGQQNGYGNIVVIKHWSGYSTAYGHMSRFAPKLKKGMKVSQNDVIGFV 444 PI AA D + F+GQQ GYGN+V++ H GY T YGHMSRF K+K G K++Q VIG+V Sbjct: 280 PIMAAGDARVQFIGQQRGYGNVVILNHGKGYRTLYGHMSRFG-KIKAGQKINQGTVIGYV 338 Query: 445 GMTGWATGPHLHYEFRVNNQPRNPLSVDVPNNQALTGPQLQRFRAVAADM 494 GMTG ATGPHLHYEF+VN Q RNPLS+ +P + L G L FR A + Sbjct: 339 GMTGLATGPHLHYEFQVNGQHRNPLSITMPPPEPLRGKDLIAFRTQTAPL 388 >NMA2172 [M] COG0739 Membrane proteins related to metalloendopeptidases NmA Neisseria meningitidis Z2491 Length = 430 Score = 228 bits (580), Expect = 3e-59, Method: Compositional matrix adjust. Identities = 146/402 (36%), Positives = 214/402 (53%), Gaps = 15/402 (3%) Query: 79 SPKTRIIGASALFLAAFTIGAAGFAPAEPDLRDAPVNPISKELALPDLQQQISALEERSQ 138 S K R AL ++ + AA A E R V P E LP L S ++ + Sbjct: 7 SAKHRKYALRALAVSIILVSAAYIASTE---RTERVRPQRVEQKLPPLSWGGSGVQ--TA 61 Query: 139 YYVNEERVRSGDTLASLLNRLGVDDDEATAFIKSDTLARSVMQLRAGKRVVAQTDDNGEL 198 Y+V +E V+ GD+LA +L R G+ DE + + LRA + V +G Sbjct: 62 YWV-QEAVQPGDSLADVLARSGMARDEIARITEKYGGEADLRHLRADQSVHVLVGGDGGA 120 Query: 199 VKLSATLDDGSDTPKNLV-ISRQDGKLTAQAQPAVLERRVEMRAGIIYSSLFAATDAAQI 257 ++ D+ D +NLV + ++ G A A ++ +R+ ++ +S + A++ Sbjct: 121 REVQFFTDE--DGERNLVALEKKGGIWRRSASEADMKVLPTLRSVVVKTSARGSLARAEV 178 Query: 258 PDAVAMQLVDMFATNINFASDLRRGDRFNVVYETYYQNGDLVRTGRVLAGEFDNAGNRYQ 317 P + L +FA + L+ GD ++Y++ Y +G V G +LA E G R+Q Sbjct: 179 PVEIRESLSGIFAGRFSL-DGLKEGDAVRLIYDSLYFHGQQVAAGDILAAEVVKGGTRHQ 237 Query: 318 AVWFSDPASKTGGGGYYAFDGKSL--KKAFLKSPLAFTRISSGFSMRLHPILGKWKQHTG 375 A ++ GGG YY DG+ L K F PL +TRISS F R+HPIL W+ HTG Sbjct: 238 AFYYRSDKEGGGGGNYYDEDGRVLQEKGGFNIEPLVYTRISSPFGYRMHPILHTWRLHTG 297 Query: 376 VDFAAPTGTPIHAAADGVIDFVGQQNGYGNIVVIKHWSGYSTAYGHMSRFAPKLKKGMKV 435 +D+AAP GTP+ A+ADGVI F G++ GYGN V+I+H +G T Y H+S F+ + V Sbjct: 298 IDYAAPQGTPVRASADGVITFKGRKGGYGNAVMIRHANGVETLYAHLSAFS---QAEGNV 354 Query: 436 SQNDVIGFVGMTGWATGPHLHYEFRVNNQPRNPLSVDVPNNQ 477 +VIGFVG TG +TGPHLHYE R+N QP NP+SV +P + Sbjct: 355 RGGEVIGFVGSTGRSTGPHLHYEARINGQPVNPVSVALPTPE 396 >NMB0315 [M] COG0739 Membrane proteins related to metalloendopeptidases Nme Neisseria meningitidis MC58 Length = 430 Score = 227 bits (579), Expect = 4e-59, Method: Compositional matrix adjust. Identities = 147/400 (36%), Positives = 213/400 (53%), Gaps = 15/400 (3%) Query: 79 SPKTRIIGASALFLAAFTIGAAGFAPAEPDLRDAPVNPISKELALPDLQQQISALEERSQ 138 S K R AL ++ + AA A E R V P E LP L S ++ + Sbjct: 7 SAKHRKYALRALAVSIILVSAAYIASTE---RTERVRPQRVEQNLPPLSWGGSGVQ--TA 61 Query: 139 YYVNEERVRSGDTLASLLNRLGVDDDEATAFIKSDTLARSVMQLRAGKRVVAQTDDNGEL 198 Y+V +E V+ GD+LA +L R G+ DE + + LRA + V +G Sbjct: 62 YWV-QEAVQPGDSLADVLARSGMARDEIARITEKYGGEADLRHLRADQSVHVLVGGDGGA 120 Query: 199 VKLSATLDDGSDTPKNLV-ISRQDGKLTAQAQPAVLERRVEMRAGIIYSSLFAATDAAQI 257 ++ D+ D +NLV + ++ G A A ++ +R+ ++ +S + A++ Sbjct: 121 REVQFFTDE--DGERNLVALEKKGGIWRRSASEADMKVLPTLRSVVVKTSARGSLARAEV 178 Query: 258 PDAVAMQLVDMFATNINFASDLRRGDRFNVVYETYYQNGDLVRTGRVLAGEFDNAGNRYQ 317 P + L +FA + L+ GD ++Y++ Y +G V G +LA E G R+Q Sbjct: 179 PVEIRESLSGIFAGRFSL-DGLKEGDAVRLMYDSLYFHGQQVAAGDILAAEVVKGGTRHQ 237 Query: 318 AVWFSDPASKTGGGGYYAFDGKSL--KKAFLKSPLAFTRISSGFSMRLHPILGKWKQHTG 375 A ++ GGG YY DGK L K F PL +TRISS F R+HPIL W+ HTG Sbjct: 238 AFYYRSDKEGGGGGNYYDEDGKVLQEKGGFNIEPLVYTRISSPFGYRMHPILHTWRLHTG 297 Query: 376 VDFAAPTGTPIHAAADGVIDFVGQQNGYGNIVVIKHWSGYSTAYGHMSRFAPKLKKGMKV 435 +D+AAP GTP+ A+ADGVI F G++ GYGN V+I+H +G T Y H+S F+ + V Sbjct: 298 IDYAAPQGTPVRASADGVITFKGRKGGYGNAVMIRHANGVETLYAHLSAFS---QAEGNV 354 Query: 436 SQNDVIGFVGMTGWATGPHLHYEFRVNNQPRNPLSVDVPN 475 +VIGFVG TG +TGPHLHYE R+N QP NP+SV +P Sbjct: 355 RGGEVIGFVGSTGRSTGPHLHYEARINGQPVNPVSVALPT 394 >RC0557 [M] COG0739 Membrane proteins related to metalloendopeptidases Rco Rickettsia conorii Length = 476 Score = 200 bits (509), Expect = 6e-51, Method: Compositional matrix adjust. Identities = 123/394 (31%), Positives = 204/394 (51%), Gaps = 24/394 (6%) Query: 115 NPISKELALPDLQQQISALEERSQYYVNEERVRSGDTLASLLNRLGV---DDDEATAFIK 171 N +S L PD S+ EE + E V+ GDT+ S+L + + D+ + IK Sbjct: 74 NTLSITLVQPD-----SSEEETISF--KEVVVKKGDTIKSILIEQHIPKNEIDKIVSLIK 126 Query: 172 SDTLARSVMQLRAGKRVVAQ------TDDNGELVKLSATLDDGS---DTPKNLVISRQDG 222 L+ + L+ G+++ + +++ +L A L+ D K + + R+ Sbjct: 127 EGKLSSA---LKIGQQITFEYETKIIENEDEDLTSEVAFLNKIVIIIDKLKTIEVIREGD 183 Query: 223 KLTAQAQPAVLERRVEMRAGIIYSSLFAATDAAQIPDAVAMQLVDMFATNINFASDLRRG 282 + L ++V + I ++ +A + D ++L++ +A I+F ++RG Sbjct: 184 NFKVEEIVVPLSKKVAKSSVSIEANFMSALKKLGLSDNSIIELINAYAYQIDFQRQIKRG 243 Query: 283 DRFNVVYETYY-QNGDLVRTGRVLAGEFDNAGNRYQAVWFSDPASKTGGGGYYAFDGKSL 341 D V+ E Y ++G G++L + +G Y +S + +++ DGKS+ Sbjct: 244 DTATVITEKYVTEDGKFSHHGKILYVSLNLSGKEYNIYRYSHD-NNANNHAFFSEDGKSV 302 Query: 342 KKAFLKSPLAFTRISSGFSMRLHPILGKWKQHTGVDFAAPTGTPIHAAADGVIDFVGQQN 401 K++ LK+PL ++SS + R HPILG K H GVDFAAPTGTPI++A +GVI +G ++ Sbjct: 303 KRSLLKTPLKVIKVSSHYGNRKHPILGYTKMHRGVDFAAPTGTPIYSAGNGVITEIGWKS 362 Query: 402 GYGNIVVIKHWSGYSTAYGHMSRFAPKLKKGMKVSQNDVIGFVGMTGWATGPHLHYEFRV 461 GYG + +KH STAY H S FA LK G V Q +I +VG TG AT PHLHYE ++ Sbjct: 363 GYGKFIQVKHSGTLSTAYAHASNFAKNLKVGSIVKQGQIIAYVGSTGRATAPHLHYEVKI 422 Query: 462 NNQPRNPLSVDVPNNQALTGPQLQRFRAVAADMQ 495 + + NP+SV L G L++F+ +++ Sbjct: 423 DGKHVNPMSVKTTPGIELNGKNLEKFKQFKKEIK 456