BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.0106.p (420 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value NMB0360 [GEPR] COG0477 Permeases of the major facilitator superf... 439 e-123 NMA2127 [GEPR] COG0477 Permeases of the major facilitator superf... 430 e-120 PM0285 [GEPR] COG0477 Permeases of the major facilitator superfa... 428 e-119 HI0350 [GEPR] COG0477 Permeases of the major facilitator superfa... 362 e-100 YPO3162 [GEPR] COG0477 Permeases of the major facilitator superf... 298 2e-80 >NMB0360 [GEPR] COG0477 Permeases of the major facilitator superfamily Nme Neisseria meningitidis MC58 Length = 427 Score = 439 bits (1130), Expect = e-123, Method: Compositional matrix adjust. Identities = 230/419 (54%), Positives = 308/419 (73%), Gaps = 12/419 (2%) Query: 10 QYLNRRMLICVFLGFTSGLPLFILLSLLQAWLAKSGLNVKTLGLFALVMFPYTWKFLWSP 69 Q +R ML+C+F GFTSGLPL+ L++L+ AWL +++K++GL AL+ P+TWKFLWSP Sbjct: 11 QIFSRNMLVCIFTGFTSGLPLYFLINLIPAWLRSEQVDLKSIGLMALIGLPFTWKFLWSP 70 Query: 70 LMDRFHFGSMGRRRGWMVFTQLLLFVAIGGMGMLDPLTDVSTIAFMASVVAFLSASQDIA 129 LMD +GRRRGWM+ TQ L A+ L+P + IA ++ +VAF SASQDI Sbjct: 71 LMDAVRLPVLGRRRGWMLLTQAGLLAALAVYAFLNPRNHLPLIAGLSVLVAFFSASQDIV 130 Query: 130 IDAYRREILPEAELGLGSAIHVNAYKLSGMVPGALSLVLADQMPWPTVFWITAAFMLPGL 189 +DA+RREIL + ELGLG+++HVNAY+++ ++PG+LSLVLAD+MPW VF IT+ FMLPGL Sbjct: 131 LDAFRREILSDEELGLGNSVHVNAYRIAALIPGSLSLVLADRMPWLEVFVITSLFMLPGL 190 Query: 190 LCSL-VVKEPKVYGSPPKNLYEAVVLPFREFIARGGWRNALWVLGFIFLYKLGDSMATAL 248 L +L + +EP + + PK L + VV PF+EF R G +A+ VL FIFLYKLGDSMATAL Sbjct: 191 LMTLFLAREPVLPPAVPKTLKQTVVEPFKEFFTRKGIASAVCVLLFIFLYKLGDSMATAL 250 Query: 249 ATKFYIDLGFSMTEIGVVSKTTSLWASVAGGIIGGIWMVRLGINRGLWVFGVLQAIPILG 308 AT FY+D+GFS T+IG+++K LW +VA GI+GG+WM+++G+N+ LW+FG +QA+ +LG Sbjct: 251 ATPFYLDMGFSKTDIGLIAKNAGLWPAVAAGILGGVWMLKIGVNKALWLFGAVQAVTVLG 310 Query: 309 FAWLAHVGTSLPV-------LATVIGLEAFGVGLGTTAFVAYIMRETDPRYTATQFALFT 361 F WLA G V LA VIG EA GVGLGT AFV+Y+ RET+P +TATQ ALFT Sbjct: 311 FVWLAGFGPFDTVGTGERLMLAAVIGAEAVGVGLGTAAFVSYMARETNPAFTATQLALFT 370 Query: 362 SLMAVPRTFVNSSVGYIVAETGWLNFFLICFVLALPGMLMLPRIAPWNEKPVESQTQKA 420 SL AVPRT +NS GY++ G++ FF +CF LALPGML+L ++APWN + +TQ A Sbjct: 371 SLSAVPRTVINSFAGYLIEWLGYVPFFQLCFALALPGMLLLLKVAPWNGE----KTQDA 425 >NMA2127 [GEPR] COG0477 Permeases of the major facilitator superfamily NmA Neisseria meningitidis Z2491 Length = 427 Score = 430 bits (1106), Expect = e-120, Method: Compositional matrix adjust. Identities = 231/419 (55%), Positives = 309/419 (73%), Gaps = 12/419 (2%) Query: 10 QYLNRRMLICVFLGFTSGLPLFILLSLLQAWLAKSGLNVKTLGLFALVMFPYTWKFLWSP 69 Q +R ML+C+F GFTSGLPL+ L++L+ AWL +++K++GL AL+ P+TWKFLWSP Sbjct: 11 QIFSRNMLVCIFTGFTSGLPLYFLINLIPAWLRSEQVDLKSIGLMALIGLPFTWKFLWSP 70 Query: 70 LMDRFHFGSMGRRRGWMVFTQLLLFVAIGGMGMLDPLTDVSTIAFMASVVAFLSASQDIA 129 LMD +GRRRGWM+ TQ L A+ L+P + IA ++ +VAF SASQDI Sbjct: 71 LMDAVRLPVLGRRRGWMLLTQAGLLAALAAYAFLNPRNHLPLIAGLSVLVAFFSASQDIV 130 Query: 130 IDAYRREILPEAELGLGSAIHVNAYKLSGMVPGALSLVLADQMPWPTVFWITAAFMLPGL 189 +DA+RREIL + ELGLG+++HVNAY+++ ++PG+LSLVLAD+MPW VF IT+ FMLPGL Sbjct: 131 LDAFRREILSDEELGLGNSVHVNAYRVAALIPGSLSLVLADRMPWSEVFVITSLFMLPGL 190 Query: 190 LCSL-VVKEPKVYGSPPKNLYEAVVLPFREFIARGGWRNALWVLGFIFLYKLGDSMATAL 248 L +L + +EP + + PK L + VV PF+EF R G +A+ VL FIFLYKLGDSMATAL Sbjct: 191 LMTLFLAREPVLPPAVPKTLKQTVVEPFKEFFTRKGIASAVCVLLFIFLYKLGDSMATAL 250 Query: 249 ATKFYIDLGFSMTEIGVVSKTTSLWASVAGGIIGGIWMVRLGINRGLWVFGVLQAIPILG 308 AT FY+D+GFS T+IG+++K LW +VA GI+GG+WM+++G+N+ LW+FG +QA+ +LG Sbjct: 251 ATPFYLDMGFSKTDIGLIAKNAGLWPAVAAGILGGVWMLKIGVNKALWLFGAVQAVTVLG 310 Query: 309 FAWLAHVGTSLPV-------LATVIGLEAFGVGLGTTAFVAYIMRETDPRYTATQFALFT 361 F WLA G V LA VIG EA GVGLGT AFV+Y+ RET+P +TATQ ALFT Sbjct: 311 FVWLAGFGHFDTVGTGERLMLAAVIGAEAVGVGLGTAAFVSYMARETNPAFTATQLALFT 370 Query: 362 SLMAVPRTFVNSSVGYIVAETGWLNFFLICFVLALPGMLMLPRIAPWNEKPVESQTQKA 420 SL AVPRT +NS GY++ G++ FF +CFVLALPGML+L ++APWN + +TQ A Sbjct: 371 SLSAVPRTVINSFAGYLIEWLGYVPFFQLCFVLALPGMLLLLKVAPWNGE----KTQDA 425 >PM0285 [GEPR] COG0477 Permeases of the major facilitator superfamily Pmu Pasteurella multocida Length = 425 Score = 428 bits (1101), Expect = e-119, Method: Compositional matrix adjust. Identities = 214/413 (51%), Positives = 291/413 (70%), Gaps = 13/413 (3%) Query: 9 QQYLNRRMLICVFLGFTSGLPLFILLSLLQAWLAKSGLNVKTLGLFALVMFPYTWKFLWS 68 Q +R ML+C+F GF+SGLPL++L ++ AWL+ S ++VKT+G F L+ FPYTWKF+ S Sbjct: 10 SQIFSRNMLLCIFTGFSSGLPLYVLFQMVPAWLSSSNVDVKTIGFFTLIGFPYTWKFIIS 69 Query: 69 PLMDRFHFGSMGRRRGWMVFTQLLLFVAIGGMGMLDPLTDVSTIAFMASVVAFLSASQDI 128 PL+DR++ +GRRR WM TQ+ L + +G DP+ +++ +A +++ +A SA QDI Sbjct: 70 PLLDRYYPNFLGRRRSWMFMTQVALLALLALLGQYDPVANITIVAVISTSIAVFSAVQDI 129 Query: 129 AIDAYRREILPEAELGLGSAIHVNAYKLSGMVPGALSLVLADQMPWPTVFWITAAFMLPG 188 IDAYRREIL + ELGLG++IHVNAY++SG++PG LSL+LAD +PW VF TA FM+PG Sbjct: 130 VIDAYRREILTDEELGLGNSIHVNAYRISGLIPGGLSLILADSLPWDVVFIFTALFMIPG 189 Query: 189 LLCSLVVKE----PKVYGSPPKNLYEAVVLPFREFIARGGWRNALWVLGFIFLYKLGDSM 244 L+ SL + + P++ S P Y LPF+EF +R G +AL ++ FIFLYK GDS+ Sbjct: 190 LILSLFLSKEPDVPQIDRSLP--FYHTFALPFKEFFSRKGVASALGLIFFIFLYKFGDSL 247 Query: 245 ATALATKFYIDLGFSMTEIGVVSKTTSLWASVAGGIIGGIWMVRLGINRGLWVFGVLQAI 304 AT+L TKF +D+GFS T+IG V K SLWAS+ G++GGI M+R+GINR LW+FG +Q I Sbjct: 248 ATSLQTKFILDMGFSKTDIGTVVKLNSLWASIISGMLGGILMLRIGINRSLWLFGFVQLI 307 Query: 305 PILGFAWLAHVGT-------SLPVLATVIGLEAFGVGLGTTAFVAYIMRETDPRYTATQF 357 ILGF W+A G VL TVI E GVGLGT AFVA++ RET+P YTATQ Sbjct: 308 TILGFVWMASYGKFNTIGSFEFFVLTTVIIGEYIGVGLGTAAFVAFMARETNPLYTATQL 367 Query: 358 ALFTSLMAVPRTFVNSSVGYIVAETGWLNFFLICFVLALPGMLMLPRIAPWNE 410 A+FTSL A+P ++ G +VA+ G+ FF ICF A+PGMLML ++APW+ Sbjct: 368 AIFTSLSAIPSKIFSAFSGVLVADYGYYTFFWICFFAAIPGMLMLFKVAPWHS 420 >HI0350 [GEPR] COG0477 Permeases of the major facilitator superfamily Hin Haemophilus influenzae Length = 425 Score = 362 bits (929), Expect = e-100, Method: Compositional matrix adjust. Identities = 197/417 (47%), Positives = 271/417 (64%), Gaps = 9/417 (2%) Query: 10 QYLNRRMLICVFLGFTSGLPLFILLSLLQAWLAKSGLNVKTLGLFALVMFPYTWKFLWSP 69 Q R+MLIC F GF SGLPLF+L +L WL L+++ +G VM PY KFLW+P Sbjct: 8 QIFTRKMLICAFTGFNSGLPLFVLSQMLPVWLTDKHLSIELIGAVTGVMLPYGLKFLWAP 67 Query: 70 LMDRFHFGSMGRRRGWMVFTQLLLFVAIGGMGMLDPLTDVSTIAFMASVVAFLSASQDIA 129 L+DR+ +GRRR WM+ +Q+ L + + + + DPLT + T+A +A ++AF SA+QDI Sbjct: 68 LLDRYFPSFLGRRRSWMLLSQVALLILLYIISLFDPLTQLGTVANIALLIAFFSATQDIV 127 Query: 130 IDAYRREILPEAELGLGSAIHVNAYKLSGMVPGALSLVLADQMPWPTVFWITAAFMLPGL 189 +DAYRREIL + ELGLG+ IH+NAY+++G++PG LSL LA PW TVF TA ML G+ Sbjct: 128 LDAYRREILSDHELGLGNTIHINAYRIAGLIPGGLSLYLAAIYPWETVFLWTALCMLAGI 187 Query: 190 LCSL-VVKEPKV-YGSPPKNLYEAVVLPFREFIARGGWRNALWVLGFIFLYKLGDSMATA 247 +L + KEPK+ + Y+A +P +EF R G A+ L F+FLYK GDS AT Sbjct: 188 FMTLFLAKEPKIDMQQTNQPFYQAFWIPLQEFFQRKGVIQAIGFLLFLFLYKFGDSFATT 247 Query: 248 LATKFYIDLGFSMTEIGVVSKTTSLWASVAGGIIGGIWMVRLGINRGLWVFGVLQAIPIL 307 L TKF D+GFS +I +V K+T+LW+S+ G+ GG+ M++LGINR LW+FG++Q + I Sbjct: 248 LQTKFIYDMGFSKEDIAIVVKSTALWSSILSGLAGGMIMLKLGINRALWLFGLVQMVTIG 307 Query: 308 GFAWLAHVG-------TSLPVLATVIGLEAFGVGLGTTAFVAYIMRETDPRYTATQFALF 360 GF WLA G L L VI E GVGLGT AFVA++ RE++P YTATQ ALF Sbjct: 308 GFIWLAAFGHFDVITSAELWKLGVVIAAEYIGVGLGTAAFVAFMARESNPLYTATQLALF 367 Query: 361 TSLMAVPRTFVNSSVGYIVAETGWLNFFLICFVLALPGMLMLPRIAPWNEKPVESQT 417 TSL A+P + GY+V G+ +F C LA+PGML L +AP ++ ++ + Sbjct: 368 TSLSALPSKVLGILSGYVVGAVGYYQYFWFCLFLAIPGMLCLFWVAPLKQENNKTSS 424 >YPO3162 [GEPR] COG0477 Permeases of the major facilitator superfamily Ype Yersinia pestis Length = 492 Score = 298 bits (762), Expect = 2e-80, Method: Compositional matrix adjust. Identities = 168/411 (40%), Positives = 252/411 (61%), Gaps = 10/411 (2%) Query: 11 YLNRRMLICVFLGFTSGLPLFILLSLLQAWLAKSGLNVKTLGLFALVMFPYTWKFLWSPL 70 + R +I + LGF SGLPL + LQAW+ +N+KT+G+F+LV Y +KFLWSPL Sbjct: 9 FTQRNSIILLLLGFASGLPLALTSGTLQAWMTVENVNLKTIGIFSLVGQAYVFKFLWSPL 68 Query: 71 MDRFHFGSMGRRRGWMVFTQLLLFVAIGGMGMLDPLTDVSTIAFMASVVAFLSASQDIAI 130 MDR+ +GRRRGW++ +QLLL +AI MG ++P + +A +A +VAF SASQDI Sbjct: 69 MDRYTPSFLGRRRGWLLVSQLLLIIAIIAMGFMEPAKHLWWLAAVAVLVAFCSASQDIVF 128 Query: 131 DAYRREILPEAELGLGSAIHVNAYKLSGMVPGALSLVLADQ-MPWPTVFWITAAFMLPGL 189 DAY+ ++L E G G+A+ V Y+L+ +V G L+L +AD+ + W + +W+ A ML G+ Sbjct: 129 DAYKTDLLTTEERGTGAAVSVLGYRLAMLVSGGLALWIADRYLGWQSTYWLMAGLMLIGV 188 Query: 190 LCSLVVKEPKVYGSPPKNLYEAVVLPFREFIARGGWRNALWVLGFIFLYKLGDSMATALA 249 +L+ EP + +PPK L +A+V P R+F R NA +L I YK+GD+ A +L+ Sbjct: 189 FATLLAPEPDIRIAPPKTLEQAIVAPLRDFFGR---NNAWLILLLIVFYKMGDAFAASLS 245 Query: 250 TKFYID-LGFSMTEIGVVSKTTSLWASVAGGIIGGIWMVRLGINRGLWVFGVLQAIPILG 308 T F I +GF E+G+V+KT L A++ G + GG+ M RL + R L +FG+LQA+ +G Sbjct: 246 TTFLIRGVGFDAGEVGLVNKTLGLIATIIGALYGGLLMQRLSLFRALMIFGILQAVSNMG 305 Query: 309 FAWLAHVGTSLPVLATVIGLEAFGVGLGTTAFVAYIMRETDPRYTATQFALFTSLMAVPR 368 + LA ++ + + I LE G+GT AFVA +M + ++ATQFAL ++L AV R Sbjct: 306 YWLLAITDKNIFSMGSAIFLENLCGGMGTAAFVALLMTLCNKSFSATQFALLSALSAVGR 365 Query: 369 TFVNSSVGYIVAETGWLNFFLICFVLALPGMLMLPRIAPWNEKPVESQTQK 419 +V G+ V GW F+L A+PG+L+L + + TQK Sbjct: 366 VYVGPIAGWFVEAHGWPLFYLFSIAAAIPGLLLL-----YVCRQTLDHTQK 411