BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0001.0078.p (281 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value mlr7896 [GER] COG0697 Permeases of the drug/metabolite transport... 225 1e-58 mll3062 [GER] COG0697 Permeases of the drug/metabolite transport... 186 6e-47 BMEI1244 [GER] COG0697 Permeases of the drug/metabolite transpor... 179 4e-45 SMc01807 [GER] COG0697 Permeases of the drug/metabolite transpor... 172 9e-43 STM3796A [GER] COG0697 Permeases of the drug/metabolite transpor... 153 5e-37 >mlr7896 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Mlo Mesorhizobium loti Length = 278 Score = 225 bits (573), Expect = 1e-58, Method: Compositional matrix adjust. Identities = 134/281 (47%), Positives = 168/281 (59%), Gaps = 3/281 (1%) Query: 1 MNLAVIALVLTAALLHASWNALLKSSHDRLASLSLMTLGAGLGAIPLLLWRPLPHIDSWC 60 M+ VI L L AA+LHASWNA L++ DRL ++++M+ AIPL ++ P +W Sbjct: 1 MSPLVIGLALFAAILHASWNAFLRTGADRLWTVTVMSFSDTALAIPLAIFNGFPATSAWP 60 Query: 61 YILLSGLLHTGYNLFLIRAYRIGDFGQSYPIARGSSPLLVALGAALFAGEQLGIYTVIGI 120 Y+ LS L GY++FL+ AYR G+ GQ YPI RGS PLLV LG L AG+QL TV Sbjct: 61 YVGLSACLQVGYSVFLVAAYRYGELGQVYPIVRGSVPLLVTLGGFLLAGQQL---TVPET 117 Query: 121 TLVSVGIVSLADLRAMRRREHLSAPLAALATGAFIAAYTITDGIGARLAGDAIAYAGWLF 180 V + + L R R ++ L ALATGA IA Y D IG R AG+ AY W+ Sbjct: 118 VGVVLVGGGIMGLSLGRGRAATTSILYALATGAIIAVYATVDAIGVRAAGNVGAYTAWVL 177 Query: 181 LADSFALAVIYHCQHGRSPVVLSHKETWIGLGGGLMSLLAYGIVIWAVTLAPMGMVSALR 240 LA L + GR PV ETW LGGGL +LLAYG+V+ A L P G ++A+R Sbjct: 178 LAYGALLPATFVACRGRLPVDPRAPETWKALGGGLFALLAYGVVVAAFALGPAGPITAIR 237 Query: 241 ETSVLFALLIGTLFLGEKLTLRRVLSCLVIAAGAIVLGAHH 281 ETSV+FA IG LFLGE LT RRV +C V+A GAI LG Sbjct: 238 ETSVVFAAFIGRLFLGETLTPRRVGACAVVALGAICLGYQS 278 >mll3062 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Mlo Mesorhizobium loti Length = 281 Score = 186 bits (472), Expect = 6e-47, Method: Compositional matrix adjust. Identities = 116/261 (44%), Positives = 159/261 (60%), Gaps = 3/261 (1%) Query: 19 WNALLKSSHDRLASLSLMTLGAGLGAIPLLLWRPLPHIDSWCYILLSGLLHTGYNLFLIR 78 WNAL+K DR S++LMTLG G A+ +L + P + W +IL S + H GY FLI Sbjct: 19 WNALVKVHLDRFLSITLMTLGMGFAALFVLPFVEFPKAEVWPFILASVVFHMGYRTFLIG 78 Query: 79 AYRIGDFGQSYPIARGSSPLLVALGAALFAGEQLGIYTVIGITLVSVGIVSLADLR--AM 136 AYR GDF Q+YP+ARG++PLL ALG + E + ++GI L+S G + + R A Sbjct: 79 AYRAGDFAQTYPLARGTAPLLAALGGIVVVQEVPAPFAILGILLLSAGTLVM-SFRGGAH 137 Query: 137 RRREHLSAPLAALATGAFIAAYTITDGIGARLAGDAIAYAGWLFLADSFALAVIYHCQHG 196 R +L A AL T FIA+YT++DG GARLA A +YA WLF+ D+ V+ G Sbjct: 138 LERLNLRAVGFALGTSIFIASYTLSDGSGARLAATAQSYAAWLFVCDATWALVLCVVFRG 197 Query: 197 RSPVVLSHKETWIGLGGGLMSLLAYGIVIWAVTLAPMGMVSALRETSVLFALLIGTLFLG 256 + + ++ GL G++S AY IV+WA+T AP+ V++LRETS+LFA+LI LG Sbjct: 198 PQSLPVLARDWKAGLFTGVLSGAAYWIVMWAMTKAPIASVASLRETSILFAMLISVYALG 257 Query: 257 EKLTLRRVLSCLVIAAGAIVL 277 EK+T R + L I AG I L Sbjct: 258 EKMTGWRGAAALSIVAGVIAL 278 >BMEI1244 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Bme Brucella melitensis Length = 281 Score = 179 bits (455), Expect = 4e-45, Method: Compositional matrix adjust. Identities = 113/279 (40%), Positives = 169/279 (60%), Gaps = 3/279 (1%) Query: 1 MNLAVIALVLTAALLHASWNALLKSSHDRLASLSLMTLGAGLGAIPLLLWRPLPHIDSWC 60 M+ V+ +VL A LH SWNA++K S D+ + +T AGL A+ L+ + PLP SW Sbjct: 1 MSGGVLLIVLFGAFLHTSWNAIVKGSGDKFFGAASVTGAAGLIALFLVPFLPLPTAASWI 60 Query: 61 YILLSGLLHTGYNLFLIRAYRIGDFGQSYPIARGSSPLLVALGAALFAGEQLGIYTVIGI 120 Y+LLS + T Y + AY+ GD ++YPI RG+ PLLVAL + GE +G + +GI Sbjct: 61 YMLLSTITQTFYMSLVAAAYKSGDMSEAYPIMRGTPPLLVALVSGPLVGEIMGWQSWLGI 120 Query: 121 TLVSVGIVSLA-DLRAMRRREHLSAPLAALATGAFIAAYTITDGIGARLAGDAIAYAGWL 179 L+ G++++A D R R L ALA FIA+YT+ DG+G R++G+ ++Y WL Sbjct: 121 VLICSGVLAMALDARRRNRGASSRTVLLALANAGFIASYTLIDGLGVRVSGEPLSYTLWL 180 Query: 180 FLADSFALAVIYHCQHGRSPVVLSHKETW-IGLGGGLMSLLAYGIVIWAVTLAPMGMVSA 238 FL ++ LA + S + + W L GG+ +L +YG+ +WA+T+AP+ +V+A Sbjct: 181 FLLNAVPLAG-WALYREPSRFINYIRNRWRPALIGGVGTLGSYGLALWAMTMAPIAVVAA 239 Query: 239 LRETSVLFALLIGTLFLGEKLTLRRVLSCLVIAAGAIVL 277 LRET++LF +LI L L EK+ L R ++ I AGAI L Sbjct: 240 LRETAILFGMLISALILKEKVGLPRFVAAGFIVAGAIAL 278 >SMc01807 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Sme Sinorhizobium meliloti Length = 278 Score = 172 bits (435), Expect = 9e-43, Method: Compositional matrix adjust. Identities = 106/271 (39%), Positives = 163/271 (60%), Gaps = 4/271 (1%) Query: 1 MNLAVIALVLTAALLHASWNALLKSSHDRLASLSLMTLGAGLGAIPLLLWRPLPHIDSWC 60 M VIALVL ALLHA+WNAL+K+ ++ ++++LG + A+P L + P+P ++ Sbjct: 1 MPPDVIALVLLGALLHATWNALVKAGTEKSLDAAMVSLGGAVVALPFLPFLPMPGSEAVP 60 Query: 61 YILLSGLLHTGYNLFLIRAYRIGDFGQSYPIARGSSPLLVALGAALFAGEQLGIYTVIGI 120 YIL+S L Y + AYR GD G YP+ RG +PL+VA ++L GE+L + GI Sbjct: 61 YILVSALFQFAYFQLVAAAYRAGDIGLVYPLMRGVAPLIVAATSSLVIGEKLTGGAMAGI 120 Query: 121 TLVSVGIVSLADLRAMRRREHLSAPLAALATGAFIAAYTITDGIGARLAGDAIAYAGWLF 180 +S G+++LA R+ A + AL IA+YT DGIGAR++G+AI+Y W+ Sbjct: 121 MTISAGVLTLAF---ESRKGGRHAIVLALLNACVIASYTYVDGIGARISGNAISYTLWMA 177 Query: 181 LADSFALAVIYHCQHGRSPVVLS-HKETWIGLGGGLMSLLAYGIVIWAVTLAPMGMVSAL 239 L L + G PV + W GL GG S+ +YG+ +WA+T AP+ V+AL Sbjct: 178 LLPPVLLFGWAFARRGVKPVARHVSRHWWRGLIGGAGSIGSYGLALWAMTKAPVATVAAL 237 Query: 240 RETSVLFALLIGTLFLGEKLTLRRVLSCLVI 270 RET++LFA++I +FL E+++ R+++ +I Sbjct: 238 RETAILFAVVISVVFLKERVSAWRIIAAFII 268 >STM3796A [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Sty Salmonella typhimurium LT2 Length = 286 Score = 153 bits (386), Expect = 5e-37, Method: Compositional matrix adjust. Identities = 102/280 (36%), Positives = 159/280 (56%), Gaps = 10/280 (3%) Query: 1 MNLAVIALVLTAALLHASWNALLKSSHDRLASLSLMTLGAGLGAIPLLLWRPLPHIDSWC 60 M L+V ++L AALLHASWNA++K+ +D+L + ++ A + A+ LL + P P S Sbjct: 10 MTLSVFCILLFAALLHASWNAIVKAGNDKLYAAIGVSGSAAVMALILLPFSPQPAHASIP 69 Query: 61 YILLSGLLHTGYNLFLIRAYRIGDFGQSYPIARGSSPLLVALGAALFAGEQLGIYTVIGI 120 ++ S L Y + + + Y++ D Q+YP+ RG++PLLVAL + LF G+ L +GI Sbjct: 70 FLAASTALQVVYTVLVAKTYQVSDMSQTYPLMRGTAPLLVALISVLFLGDSLSSLAWVGI 129 Query: 121 TLVSVGIVSLA-DLRAMRRREHLSAPLAALATGAFIAAYTITDGIGARLAGDAIAYAGWL 179 ++ + I+ +A + RA +R + AL FIA YT+ DG G RL+ A+ Y W Sbjct: 130 AVICMAILGMACNGRASSQR----GVVLALTNACFIAGYTLVDGTGVRLSETALGYTLWS 185 Query: 180 FLADSFALAVIYHCQHGRSPVVLSHKETWIGLGGGLMSLLAYGIVIWAVTLAPMGMVSAL 239 F + L R ++ G+ GG+ ++ +YG+ +WA+T AP+ +V+AL Sbjct: 186 FFLNGACLLTWAMIARRREASRYLAQQWKKGIFGGIGTMGSYGLALWAMTQAPLAVVAAL 245 Query: 240 RETSVLFALLIGTLFLGEKLTLRRVLSCLVIAAGAIVLGA 279 RETS+LF LI L L EK+ R ++AAG I LGA Sbjct: 246 RETSILFGALIAWLLLKEKVAGLR-----LVAAGGIALGA 280