BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0050.0100.p (522 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc2727 [GEPR] COG0477 Permeases of the major facilitator superf... 688 0.0 PA3137 [GEPR] COG0477 Permeases of the major facilitator superfa... 345 2e-94 mll0994 [GEPR] COG0477 Permeases of the major facilitator superf... 337 5e-92 RC0200 [GEPR] COG0477 Permeases of the major facilitator superfa... 282 2e-75 RP157 [GEPR] COG0477 Permeases of the major facilitator superfam... 280 7e-75 >RSc2727 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 511 Score = 688 bits (1775), Expect = 0.0, Method: Compositional matrix adjust. Identities = 365/509 (71%), Positives = 427/509 (83%) Query: 14 ANGEKADAAAWLAVAAGTLGALMATLDISIVNSSLPTIQGEIGASGTEGTWIATAYLVAE 73 ANG +ADAAAW AVAAGTLGA+MATLDISIVNS+LPTIQGEIGA+ TEGTWIATAYLVAE Sbjct: 3 ANGSRADAAAWAAVAAGTLGAMMATLDISIVNSALPTIQGEIGATSTEGTWIATAYLVAE 62 Query: 74 IVIIPMSAWLERLLGLRVLLLTAASLFTLFSVLCGLSTTLPMMIVGRVGQGFTGGALIPT 133 I+IIP++ WLE+LLGLR LLL A LFT FS+LCG++ TLPMM++GR GQGFTGG LIPT Sbjct: 63 IIIIPLAGWLEKLLGLRNLLLAATGLFTGFSMLCGVAETLPMMVIGRAGQGFTGGVLIPT 122 Query: 134 AMTIIATRLPRSQQPVGNAMFGATAILGPVLGPVMGGWLTENVSWHYAFFINLPVGAALI 193 AMTIIA RLPR+QQP+G A+FG+T ILGPV GP++GGW+T ++WHYAFFINLP+ L Sbjct: 123 AMTIIAARLPRAQQPLGTALFGSTVILGPVFGPMLGGWMTTQLNWHYAFFINLPICGVLA 182 Query: 194 TLLLVAIPYERPKFEQLAEADWFGIAGLALGLGGLTVVLEEGEREQWFSSPDIRWLAATS 253 LLL+ +P+ERP+ L EADW GIAGLALGLGG+TVVLEEG+R QWF+SP IRWLAA S Sbjct: 183 ALLLLGMPHERPRTALLREADWAGIAGLALGLGGMTVVLEEGQRLQWFTSPAIRWLAAVS 242 Query: 254 VLGFILLAIGQVRARHPVIQLRLLRDRQFGSVVMMAMIVGVALYGTAYVIPQFLSGIAGY 313 LGF LL GQ RAR PVI+L LLRDRQFG++ +MA+ +ALYGTAYVIPQFL GIAGY Sbjct: 243 ALGFGLLGWGQARARAPVIRLGLLRDRQFGAIAVMAIAASMALYGTAYVIPQFLVGIAGY 302 Query: 314 NSLQSGWIVLLSGVPMILMMPFTPLLMRLVDIRIAVGTGFLLLAASAFIETDLSPLSYGG 373 ++LQSGWIVLLSG+PMI++MP PL++R +D+R+AVG G L+LA SA+IET LSPLS G Sbjct: 303 DALQSGWIVLLSGLPMIVLMPMLPLMLRWLDVRLAVGGGLLVLALSAYIETGLSPLSTGN 362 Query: 374 SFVASQLMRGVGTVLAMLFLNQAAIRSVPPSQAGDASGLYSAARNLGGSLALAAIAVIQD 433 SFVASQLMRG+GTVL M+FLNQAAIRSVPPSQA DASGLY+ RNLGGS+ALA IA +Q+ Sbjct: 363 SFVASQLMRGLGTVLTMMFLNQAAIRSVPPSQASDASGLYNGLRNLGGSIALACIATLQE 422 Query: 434 QRLWLHSRRLEESLNANSDLVQSSMTAQGHLLGGQDVALQLMGATIQSQALTMTYADLFW 493 QRLWLHSRR+E++L AN+ VQ + Q H LG Q AL M +IQ QALTM YADLFW Sbjct: 423 QRLWLHSRRIEDTLQANAAGVQDYIAGQAHALGSQAAALLSMEQSIQVQALTMAYADLFW 482 Query: 494 MLGVAILCVTPLVLFLRPLPTHAAPVASH 522 +L VAIL VTPLV+FLRPLP HA PVA H Sbjct: 483 LLTVAILLVTPLVVFLRPLPRHAGPVAGH 511 >PA3137 [GEPR] COG0477 Permeases of the major facilitator superfamily Pae Pseudomonas aeruginosa Length = 499 Score = 345 bits (884), Expect = 2e-94, Method: Compositional matrix adjust. Identities = 192/482 (39%), Positives = 278/482 (57%) Query: 32 LGALMATLDISIVNSSLPTIQGEIGASGTEGTWIATAYLVAEIVIIPMSAWLERLLGLRV 91 LGA MA LDI I NSSL IQG + A+ EG+WI+T+YLVAEI++IPM+AWL +LL R Sbjct: 6 LGAFMAVLDIQITNSSLKDIQGALAATLEEGSWISTSYLVAEIIMIPMTAWLVQLLSARR 65 Query: 92 LLLTAASLFTLFSVLCGLSTTLPMMIVGRVGQGFTGGALIPTAMTIIATRLPRSQQPVGN 151 L + + F + S+LC + L MIV R QGFTGGALIP A T+ +LP +P G Sbjct: 66 LAVMISVGFLVSSLLCSFAWNLESMIVFRAMQGFTGGALIPLAFTLALVKLPEHHRPKGM 125 Query: 152 AMFGATAILGPVLGPVMGGWLTENVSWHYAFFINLPVGAALITLLLVAIPYERPKFEQLA 211 A+F TA P +GP +GGWLTEN W Y F+IN+P G +I LL + + P +E L Sbjct: 126 ALFAITATFAPSIGPTLGGWLTENFGWEYIFYINVPPGLLMIAGLLYGLEKKAPHWELLK 185 Query: 212 EADWFGIAGLALGLGGLTVVLEEGEREQWFSSPDIRWLAATSVLGFILLAIGQVRARHPV 271 D+ GI L +GLG L V LEEG R+ W S I L + ++ +L I Q+ +P+ Sbjct: 186 STDYAGIVTLGIGLGCLQVFLEEGHRKDWLESQLIVSLGSVALFSLVLFVILQLSRPNPL 245 Query: 272 IQLRLLRDRQFGSVVMMAMIVGVALYGTAYVIPQFLSGIAGYNSLQSGWIVLLSGVPMIL 331 I L +LR+R FG + ++ +G+ LYG+ YV+P +L+ I GYN++Q G +++ G+P + Sbjct: 246 IDLGILRNRNFGLASISSIGLGMGLYGSIYVLPLYLAQIQGYNAMQIGEVIMWMGIPQLF 305 Query: 332 MMPFTPLLMRLVDIRIAVGTGFLLLAASAFIETDLSPLSYGGSFVASQLMRGVGTVLAML 391 ++P P LM+LV R+ GF L ++F L+P G F QL+R +G + M+ Sbjct: 306 LIPLVPKLMKLVSPRLLCAAGFGLFGLASFFSGVLNPDFAGPQFNQIQLLRALGQPMIMV 365 Query: 392 FLNQAAIRSVPPSQAGDASGLYSAARNLGGSLALAAIAVIQDQRLWLHSRRLEESLNANS 451 ++ A + P AG AS L++ RNLGG++ +A +A + D R ++ L E+L + Sbjct: 366 TISLIATAYLQPQDAGSASSLFNILRNLGGAIGIALLATLLDSRAKVYFDYLREALVPTN 425 Query: 452 DLVQSSMTAQGHLLGGQDVALQLMGATIQSQALTMTYADLFWMLGVAILCVTPLVLFLRP 511 V + LG Q AL + QA+ M Y D F ++G+ + VL R Sbjct: 426 PQVDERLAQLAAQLGSQQAALGKLSEITHQQAMIMAYNDAFHVIGMVLAVSMLAVLLTRS 485 Query: 512 LP 513 LP Sbjct: 486 LP 487 >mll0994 [GEPR] COG0477 Permeases of the major facilitator superfamily Mlo Mesorhizobium loti Length = 537 Score = 337 bits (863), Expect = 5e-92, Method: Compositional matrix adjust. Identities = 198/532 (37%), Positives = 301/532 (56%), Gaps = 17/532 (3%) Query: 4 APAKP-MAAAGANGEKADAAAWLAVAAGTLGALMATLDISIVNSSLPTIQGEIGASGTEG 62 APA+P G+ G A W+AV +LGA MA L+I IVN+SL IQG IGA +G Sbjct: 10 APARPARNETGSAGTAASPRVWVAVVGSSLGAFMAVLNIQIVNASLADIQGAIGAGIDDG 69 Query: 63 TWIATAYLVAEIVIIPMSAWLERLLGLRVLLLTAASLFTLFSVLCGLSTTLPMMIVGRVG 122 WI+TAYL+AEIV+IP++ WL ++ LR L+ A LF FSV C + L MIV R Sbjct: 70 GWISTAYLIAEIVVIPLTGWLSQVFSLRNYLIANAVLFLAFSVACAFAANLGQMIVLRAI 129 Query: 123 QGFTGGALIPTAMTIIATRLPRSQQPVGNAMFGATAILGPVLGPVMGGWLTENVSWHYAF 182 QGFTGG LIP A TI+ T LP+++QP+G A+F +A P +GP +GG+LTEN W Y F Sbjct: 130 QGFTGGVLIPMAFTIVITLLPKARQPIGLALFAMSATFAPAIGPTIGGYLTENWGWQYIF 189 Query: 183 FINLPVGAALITLLLVAIPYERPKFEQLAEADWFGIAGLALGLGGLTVVLEEGEREQWFS 242 ++N+ GA ++ +L ++ + + L E DW GIA +A+GL L VLEEG + WF Sbjct: 190 YVNIVPGALMVGMLWFSLDRQPMRLALLGEGDWPGIATMAIGLAALQTVLEEGNKNDWFG 249 Query: 243 SPDIRWLAATSVLGFILLAIGQVRARHPVIQLRLLRDRQFGSVVMMAMIVGVALYGTAYV 302 S + LA + + L ++ + HP++ LRLL R FG ++ ++G ALYG+ ++ Sbjct: 250 SLFVLRLAIVAAVSLSLFVWIELTSSHPLLNLRLLLRRNFGFGILANFMLGTALYGSVFI 309 Query: 303 IPQFLSGIAGYNSLQSGWIVLLSGVPMILMMPFTPLLMRLVDIRIAVGTGFLLLAASAFI 362 +P +L+ I GYN+ Q G ++ +G+P +L++P P LM+ D+R+ + TGF L AAS F+ Sbjct: 310 LPVYLARIQGYNAEQIGLVLAWTGLPQLLLIPLVPYLMQRFDVRLVIVTGFALFAASNFM 369 Query: 363 ETDLSPLSYGGSFVASQLMRGVGTVLAMLFLNQAAIRSVPPSQAGDASGLYSAARNLGGS 422 ++ ++R +G L L+ A+ + AG AS L++ RNLGG+ Sbjct: 370 NVHMTAGYASDQLFWPNIVRAIGQALVFAPLSAIAVSGIEQENAGSASSLFNMIRNLGGA 429 Query: 423 LALAAIAVIQDQRLWLHSRRLEESLNANSDLVQS----------SMTAQGHLLGGQD--V 470 + +A + +R HS L +S++ + +S S H+L Q + Sbjct: 430 VGIALLQTFLTKRQQYHSNVLVQSISLFEEATRSRIAKLTAYFLSHGVSDHVLAAQKGVI 489 Query: 471 ALQLMGATIQSQALTMTYADLFWMLGVAILCVTPLVLFLRPLPTHAAPVASH 522 A+ L ++ QA M ++D F++LGVA++ L L+ P H +H Sbjct: 490 AIAL---RVRQQAFIMAFSDTFFLLGVALVIALAATLLLKK-PGHIEAGGAH 537 >RC0200 [GEPR] COG0477 Permeases of the major facilitator superfamily Rco Rickettsia conorii Length = 519 Score = 282 bits (721), Expect = 2e-75, Method: Compositional matrix adjust. Identities = 166/485 (34%), Positives = 275/485 (56%), Gaps = 10/485 (2%) Query: 32 LGALMATLDISIVNSSLPTIQGEIGASGTEGTWIATAYLVAEIVIIPMSAWLERLLGLRV 91 +G M+ LDI IV SSL I + AS E +W+ T+YL+AE++IIP++ +L RLL R+ Sbjct: 24 VGMFMSVLDIQIVASSLSVIAAGLAASSDELSWVQTSYLIAEVIIIPITGFLARLLTTRI 83 Query: 92 LLLTAASLFTLFSVLCGLSTTLPMMIVGRVGQGFTGGALIPTAMTIIATRLPRSQQPVGN 151 AA FT+ S+LC L+T + MI+ R QGF GGA+IPT + + P SQ+P+ Sbjct: 84 SYFIAALGFTVMSILCSLATNIESMIIFRALQGFFGGAMIPTVFSTVFILFPASQRPIVT 143 Query: 152 AMFGATAILGPVLGPVMGGWLTENVSWHYAFFINLPVGAALITLLLVAIPYERPKFEQLA 211 + G + P LGP +GG++TE +SWH+ F +N+ G + T++ + +++P ++ L Sbjct: 144 ILIGLVVTVAPTLGPTLGGYITEILSWHFMFLLNVIPGIFVCTVVFLYGDFDKPNYKLLK 203 Query: 212 EADWFGIAGLALGLGGLTVVLEEGEREQWFSSPDIRWLAATSVLGFILLAIGQVRARHPV 271 D+ GI +AL LG L VLEEG ++ W I +L+ T VLGFILL I ++ +P+ Sbjct: 204 NFDFLGILLMALTLGLLQYVLEEGNKKGWLEDNLILFLSITVVLGFILLIIRELTCINPI 263 Query: 272 IQLR--LLRDRQFGSVVMMAMIVGVALYGTAYVIPQFLSGIAGYNSLQSGWIVLLSGVPM 329 + L+ L +D FG + + ++G+ LYGT Y++P FL IAGY++LQ G ++++G Sbjct: 264 LDLKTFLYKDFTFGC--LYSFVMGIGLYGTVYILPLFLFTIAGYDTLQIGATMMVTGGAQ 321 Query: 330 ILMMPFTPLLMRL-VDIRIAVGTGFLLLAASAFIETDLSPLSYGGSFVASQLMRGVGTVL 388 L P ++ L VD+R+ + G A + + L+P S +FV Q +RG+ + Sbjct: 322 FLSAPLAGRMLGLGVDLRLMLIIGLGGFALGCHLNSFLTPDSKFAAFVLPQFVRGLSLMF 381 Query: 389 AMLFLNQAAIRSVPPSQAGDASGLYSAARNLGGSLALAAIAVIQDQRLWLHSRRLEESLN 448 + N A+ ++P + G+ASGLY+ RNLGG++ LA I+ I + L E+++ Sbjct: 382 CFIPTNNIALGNMPKERVGNASGLYNLTRNLGGAVGLAIISTILTNDTKTFMQYLSENIS 441 Query: 449 ANSDLVQSSMTAQGHLLGG-----QDVALQLMGATIQSQALTMTYADLFWMLGVAILCVT 503 + S + + + LL G + + L+ + A + ++F M+G+ + + Sbjct: 442 STSIMALEQLDSYTELLSGKVLNPEKASYLLLANKLNHDAFVIAINNIFNMIGLLFVFIM 501 Query: 504 PLVLF 508 L+ F Sbjct: 502 LLIPF 506 >RP157 [GEPR] COG0477 Permeases of the major facilitator superfamily Rpr Rickettsia prowazekii Length = 519 Score = 280 bits (715), Expect = 7e-75, Method: Compositional matrix adjust. Identities = 163/492 (33%), Positives = 275/492 (55%), Gaps = 10/492 (2%) Query: 25 LAVAAGTLGALMATLDISIVNSSLPTIQGEIGASGTEGTWIATAYLVAEIVIIPMSAWLE 84 LA +G M+ LDI IV SSL I + AS E +W+ T+YL+AE++IIP++ +L Sbjct: 17 LAFFGMIVGMFMSVLDIQIVASSLSVIAAGLAASSDELSWVQTSYLIAEVIIIPITGFLA 76 Query: 85 RLLGLRVLLLTAASLFTLFSVLCGLSTTLPMMIVGRVGQGFTGGALIPTAMTIIATRLPR 144 RLL R+ AA FT+ SVLC L+ + MI+ R QGF GGA+IP + + P Sbjct: 77 RLLSTRICYFIAALGFTIMSVLCSLANNIESMIIFRALQGFFGGAMIPLVFSTVYIIFPA 136 Query: 145 SQQPVGNAMFGATAILGPVLGPVMGGWLTENVSWHYAFFINLPVGAALITLLLVAIPYER 204 SQ+P + G + P LGP +GG++TE +SWH+ F +N+ G + T++ + + +++ Sbjct: 137 SQRPTVTILIGLVVTVAPTLGPTLGGYITEILSWHFMFLLNVIPGIFVCTVVFLYVNFDK 196 Query: 205 PKFEQLAEADWFGIAGLALGLGGLTVVLEEGEREQWFSSPDIRWLAATSVLGFILLAIGQ 264 P ++ L D+ GI ++L LG L VLEEG +E W I +L+ T LGFILL I + Sbjct: 197 PNYQLLKNFDFLGILLMSLTLGLLQYVLEEGNKEGWLDDNLILFLSITVALGFILLIIRE 256 Query: 265 VRARHPVIQLR--LLRDRQFGSVVMMAMIVGVALYGTAYVIPQFLSGIAGYNSLQSGWIV 322 + +P++ L+ L +D FG + + ++G+ LYG Y++P FL IA Y++LQ G + Sbjct: 257 LTFINPILDLKTFLYKDFTFGCI--YSFVMGIGLYGAVYILPLFLFTIAEYDTLQIGATM 314 Query: 323 LLSGVPMILMMPFTPLLMRL-VDIRIAVGTGFLLLAASAFIETDLSPLSYGGSFVASQLM 381 +++GV L P ++ L +D+R+ + G A + + L+P S +F+ Q + Sbjct: 315 MVTGVAQFLSAPLAGRMLGLGIDLRMMLTIGLGGFALGCHLNSCLTPDSKFAAFILPQFV 374 Query: 382 RGVGTVLAMLFLNQAAIRSVPPSQAGDASGLYSAARNLGGSLALAAIAVIQDQRLWLHSR 441 RG + + N A+ ++P + G+ASGLY+ RNLGG++ LA I+ I + + Sbjct: 375 RGFSLMFCFIPTNNIALGNMPKEKVGNASGLYNLTRNLGGAVGLAIISTILSNDTKIFMQ 434 Query: 442 RLEESLNANSDLVQSSMTAQGHLLGGQDV-----ALQLMGATIQSQALTMTYADLFWMLG 496 L E+++ S + + + + LL G+ + + L+ + + A + ++F M+G Sbjct: 435 YLSENISYTSIIALTRLDSYTELLSGKILNPEQGSYLLLANKLNNDAFVIAINNIFNMIG 494 Query: 497 VAILCVTPLVLF 508 + + + L+ F Sbjct: 495 LLFVFIMLLIPF 506