BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0049.0056.p (613 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc2890 [R] COG3975 Predicted protease with the C-terminal PDZ d... 732 0.0 NMB1726 [R] COG3975 Predicted protease with the C-terminal PDZ d... 419 e-117 NMA1981 [R] COG3975 Predicted protease with the C-terminal PDZ d... 415 e-115 alr2326 [R] COG3975 Predicted protease with the C-terminal PDZ d... 388 e-107 slr0031 [R] COG3975 Predicted protease with the C-terminal PDZ d... 364 e-100 >RSc2890 [R] COG3975 Predicted protease with the C-terminal PDZ domain Rso Ralstonia solanacearum Length = 621 Score = 732 bits (1890), Expect = 0.0, Method: Compositional matrix adjust. Identities = 376/605 (62%), Positives = 434/605 (71%), Gaps = 18/605 (2%) Query: 19 PIRYRITSLDPASHLFDVSVTVDAPAAEGQVFSLPAWIPGSYMIREFGKNIVQLRGECNG 78 PIRY I P +HLF V+VTVDAP +GQ FSLPAWIPGSYMIREF +NIV++ C Sbjct: 3 PIRYTIAPAAPEAHLFTVTVTVDAPDPQGQRFSLPAWIPGSYMIREFARNIVRIEAMCGE 62 Query: 79 RKVGVKKLDKHTWQAAPCKGALTLHYQVYAWDLSVRTAHLDRTHGFFNGTSVFLCAHGFE 138 R V + KLDKHTWQAAPC G LT+ Y VYAWDLSVR AHLD THGFFNGTSVFL G E Sbjct: 63 RAVRLAKLDKHTWQAAPCSGPLTVSYDVYAWDLSVRAAHLDPTHGFFNGTSVFLRVEGGE 122 Query: 139 QGEHVVELVRPEGEEFKRWRVATAMSE--------LKAKRYGFGTYVAQNYDELIDHPVE 190 Q +V++ P G+ ++ WRVATA+ E + AKRYGFG Y A +YDELIDHPVE Sbjct: 123 QVRCLVDIQPPAGDAYRGWRVATALREASGRVQGRVGAKRYGFGWYEAADYDELIDHPVE 182 Query: 191 IGDFALATFQAHGVPHDVVITGRVPNLDLARLCEDLKKICEAQIAFFEPRSKRAPM---- 246 +G FAL +F+A G HD V TGRVPNLDL R+ D K+ICEAQI FEP + AP Sbjct: 183 MGTFALVSFEACGAQHDAVFTGRVPNLDLERIARDFKRICEAQIRLFEPHTAAAPFLDSN 242 Query: 247 DRYVFMTLAVGDGYGGLEHRASTALICARADLPVKGKPEQTDGYRTYLGLCSHEYFHTWN 306 RYVFMT+ DGYGGLEHRASTALICAR DLPV G+ E T+GYRT+LGL SHEYFHTWN Sbjct: 243 RRYVFMTMVTTDGYGGLEHRASTALICARNDLPVTGRDETTEGYRTFLGLVSHEYFHTWN 302 Query: 307 VKRIKPAVFAPYDLRQENYTSLLWLFEGFTSYYDDLFLVRTGVIDTDNYLKLVGKTVTGV 366 VKRIKPAVF PY L +E +T LLWLFEGFTSYYDDL LVR+G+I YL+++ KT GV Sbjct: 303 VKRIKPAVFVPYALDREVHTPLLWLFEGFTSYYDDLMLVRSGLISEAQYLEMLAKTWNGV 362 Query: 367 LRGTGRKKQSVAESSFDAWVKYYRQDENASNAIVSYYTKGSLVALGLDLTIRTQTRGRRS 426 LRG+GR KQSVAESSFDAW KYYRQDENA NAIVSYYTKGSLVAL LDLTIRTQT G S Sbjct: 363 LRGSGRLKQSVAESSFDAWTKYYRQDENAPNAIVSYYTKGSLVALALDLTIRTQTGGEHS 422 Query: 427 LDDVMRGLWTRYGRDFY--NGKQQGVPEDEILAIMEELSGADLKRFHDRHIRGTEDVPLE 484 LDDVMR LW GRDFY Q+GV E E++A+MEE +G L+ + G +D PL Sbjct: 423 LDDVMRALWAAGGRDFYAPGHAQRGVTEAELIALMEETTGLRLRTLVRQLAEGRDDPPLP 482 Query: 485 DLLPAFGVAYEANVPADAKPWLGARIGKEGGDAKLAAVYEGGPAMLAGLSAGDKLVAIDG 544 L A GV PA+A LGA++G E G KL V++GGPA AGLSAGD +VA+DG Sbjct: 483 ALFKAIGVT-ATRKPAEAALGLGAKVGAENGFVKLLQVFDGGPAQRAGLSAGDLVVAVDG 541 Query: 545 LRVPASGPDGLLARYRLNDTVRIHAFRRDELMEFSVRLKADTAPQVSLQALAKPVAAARQ 604 LRV + D LAR+R DTV +H FRRDELM+ V L AD PQ +L A+P + Sbjct: 542 LRVLSGQLDKSLARHRAGDTVPVHVFRRDELMQLDVTLSADATPQFALALSAEP---SPL 598 Query: 605 RAAWL 609 R+AWL Sbjct: 599 RSAWL 603 >NMB1726 [R] COG3975 Predicted protease with the C-terminal PDZ domain Nme Neisseria meningitidis MC58 Length = 582 Score = 419 bits (1078), Expect = e-117, Method: Compositional matrix adjust. Identities = 243/589 (41%), Positives = 327/589 (55%), Gaps = 36/589 (6%) Query: 20 IRYRITSLDPASHLFDVSVTVDAPAAEGQVFSLPAWIPGSYMIREFGKNIVQLRGECNGR 79 I Y+IT P H + + +T SLP W+PGSY+IR+F ++I + CNG Sbjct: 2 IHYKITP-SPLDHEWHILLTFTQDDDLPIEISLPNWVPGSYLIRDFSRHITSIHASCNGT 60 Query: 80 KVGVKKLDKHTWQAAPCKGALTLHYQVYAWDLSVRTAHLDRTHGFFNGTSVFLCAHGFEQ 139 + ++++ K+ W AA +G + Y VYA+DLSVR + L GFF+G+ +FL G E Sbjct: 61 SMPLEQIAKNRWHAAAVRGEWQIRYTVYAFDLSVRGSFLTTERGFFDGSCLFLKVEGTET 120 Query: 140 GEHVVELVRPEGEEFKRWRVATAMSELKAKRYGFGTYVAQNYDELIDHPVEIGDFALATF 199 H +EL E WR+AT + E G + A +Y ELID PVE+G F Sbjct: 121 LPHRLELTGIPSE----WRIATTLPET-----GRFVFQAASYAELIDRPVEMGLIEFLDF 171 Query: 200 QAHGVPHDVVITGRVPNLDLARLCEDLKKICEAQIAFFEPRSKRAPMDRYVFMTLAVGDG 259 +A G+PH + ++G P+ D RL D+KKICE ++A F S AP +Y+F+ L VGD Sbjct: 172 EAAGIPHTIALSGIYPDFDRNRLVSDIKKICETELAVF---SSPAPFQKYLFL-LHVGDH 227 Query: 260 -YGGLEHRASTALICARADLPVKGKPEQTDGYRTYLGLCSHEYFHTWNVKRIKPAVFAPY 318 YGGLEH STAL+ R LP G + D Y T LGL SHEYFH WNVK IKPA F PY Sbjct: 228 IYGGLEHTDSTALLADRHSLPPYGMTDADDTYTTLLGLFSHEYFHAWNVKSIKPAAFVPY 287 Query: 319 DLRQENYTSLLWLFEGFTSYYDDLFLVRTGVIDTDNYLKLVGKTVTGVLRGTGRKKQSVA 378 DL +ENYT LW FEG TSYYDDLFL R+ I ++YL L+ + +T V + GR +Q++A Sbjct: 288 DLDKENYTEQLWAFEGITSYYDDLFLARSRTISPESYLNLLAQGITRVQQTRGRLRQTLA 347 Query: 379 ESSFDAWVKYYRQDENASNAIVSYYTKGSLVALGLDLTIRTQTRGRRSLDDVMRGLWTRY 438 ESSF AW K+Y+ DEN+ NAIVSYY KG+L AL LDL IR ++ GR SLD +M L+ R Sbjct: 348 ESSFTAWNKFYKPDENSPNAIVSYYQKGALAALCLDLIIRNRSNGRHSLDTLMDKLY-RE 406 Query: 439 GRDFYNGKQQGVPEDEILAIMEELSGADLKRFHDRHIRGTEDVPLEDLLPAFGVAY---- 494 RD G+PE +E++G DL+ F + + TED+PL + L GV Sbjct: 407 WRD----THSGIPEKHWQIRCQEITGLDLEDFFQKALYSTEDLPLAECLATAGVGLTFLP 462 Query: 495 ----------EANVPADAKPWLGARIGKEGGDAKLAAVYEGGPAMLAGLSAGDKLVAIDG 544 E P + GAR + L V+ GG A A L DK++A+DG Sbjct: 463 LPRQHGGGYAEHICPVPSAGDFGARFKQNTDHIVLTHVFNGGSAESAALCPQDKIIALDG 522 Query: 545 LRVPASGPDGLLARYRLNDTVRIHAFRRDELMEFSVRLKADTAPQVSLQ 593 + ARY +N + IH FR L + + ++A A L Sbjct: 523 --YACTDFTAQWARYHVNAKINIHFFRAGILRQTVLTVQAAAADTAILH 569 >NMA1981 [R] COG3975 Predicted protease with the C-terminal PDZ domain NmA Neisseria meningitidis Z2491 Length = 585 Score = 415 bits (1067), Expect = e-115, Method: Compositional matrix adjust. Identities = 243/593 (40%), Positives = 326/593 (54%), Gaps = 36/593 (6%) Query: 16 MATPIRYRITSLDPASHLFDVSVTVDAPAAEGQVFSLPAWIPGSYMIREFGKNIVQLRGE 75 M I Y+IT P H + + +T SLP W+PGSY+IR+F ++I + Sbjct: 1 MIVMIHYKITP-SPLDHEWHILLTFTQDDDLPIEISLPNWVPGSYLIRDFSRHITSIHAS 59 Query: 76 CNGRKVGVKKLDKHTWQAAPCKGALTLHYQVYAWDLSVRTAHLDRTHGFFNGTSVFLCAH 135 CNG + ++++ K+ W AA +G + Y VYA+DLSVR + L GFF+G+ +FL Sbjct: 60 CNGTSMPLEQIAKNRWHAAAVRGEWQIRYTVYAFDLSVRGSFLTTERGFFDGSCLFLKVE 119 Query: 136 GFEQGEHVVELVRPEGEEFKRWRVATAMSELKAKRYGFGTYVAQNYDELIDHPVEIGDFA 195 G E H +EL E R+AT + E G + A +Y ELID PVE+G Sbjct: 120 GTETLLHRLELTGIPSER----RIATTLPET-----GRFVFQAASYAELIDRPVEMGLIE 170 Query: 196 LATFQAHGVPHDVVITGRVPNLDLARLCEDLKKICEAQIAFFEPRSKRAPMDRYVFMTLA 255 F+A G+PH + ++G P+ D RL D+KKICE ++ F S AP +Y+F+ L Sbjct: 171 FLDFEAAGIPHTIALSGIYPDFDRNRLVSDIKKICETELTVF---SSPAPFQKYLFL-LH 226 Query: 256 VGDG-YGGLEHRASTALICARADLPVKGKPEQTDGYRTYLGLCSHEYFHTWNVKRIKPAV 314 VGD YGGLEH STAL+ R LP G + D Y T LGL SHEYFH WNVK IKPA Sbjct: 227 VGDHIYGGLEHTDSTALLADRHSLPPYGMTDADDTYTTLLGLFSHEYFHAWNVKSIKPAA 286 Query: 315 FAPYDLRQENYTSLLWLFEGFTSYYDDLFLVRTGVIDTDNYLKLVGKTVTGVLRGTGRKK 374 F PYDL +ENYT LW FEG TSYYDDLFL R+ I ++YL L+ + +T V + GR + Sbjct: 287 FVPYDLDKENYTEQLWAFEGITSYYDDLFLARSRTISPESYLNLLAQGITRVQQTRGRLR 346 Query: 375 QSVAESSFDAWVKYYRQDENASNAIVSYYTKGSLVALGLDLTIRTQTRGRRSLDDVMRGL 434 Q++AESSF AW K+Y+ DEN+ NAIVSYY KG+L AL LDL IR ++ GR SLD VM L Sbjct: 347 QTLAESSFTAWNKFYKPDENSPNAIVSYYQKGALAALCLDLIIRNRSNGRHSLDTVMDKL 406 Query: 435 WTRYGRDFYNGKQQGVPEDEILAIMEELSGADLKRFHDRHIRGTEDVPLEDLLPAFGVAY 494 + R RD G+PE +E++G DL+ F + + TED+PL + L GV Sbjct: 407 Y-REWRD----THSGIPEKHWQIRCQEITGLDLEDFFQKTLYSTEDLPLAECLATAGVGL 461 Query: 495 --------------EANVPADAKPWLGARIGKEGGDAKLAAVYEGGPAMLAGLSAGDKLV 540 E P + GAR + L V+ GG A A L DK++ Sbjct: 462 TFLPLPRQHGGGYAEHICPVPSAGDFGARFKQNTDHIVLTHVFNGGSAESAALCPQDKII 521 Query: 541 AIDGLRVPASGPDGLLARYRLNDTVRIHAFRRDELMEFSVRLKADTAPQVSLQ 593 A+DG + ARY +N + IH FR L + + ++A A L Sbjct: 522 ALDG--YACTDFTAQWARYHVNAKINIHFFRAGILRQTVLTVQAAAADTAILH 572 >alr2326 [R] COG3975 Predicted protease with the C-terminal PDZ domain Nos Nostoc sp. PCC 7120 Length = 543 Score = 388 bits (997), Expect = e-107, Method: Compositional matrix adjust. Identities = 207/560 (36%), Positives = 314/560 (56%), Gaps = 27/560 (4%) Query: 52 LPAWIPGSYMIREFGKNIVQLRGECNGRKVGVKKLDKHTWQAAPCK-GALTLHYQVYAWD 110 +P W PGSY++RE+ KN+ + + +K+ K+ WQ +T+ Y+++A + Sbjct: 1 MPVWTPGSYLVREYAKNLQDFTAFAGDKILPWRKISKNHWQINKGDVSEVTVRYRIFANE 60 Query: 111 LSVRTAHLDRTHGFFNGTSVFLCAHGFEQGEHVVELVRPEGEEFKRWRVATAMSELKAKR 170 LSVRT HLD THG+FNG ++F G+E V ++ P + +WRV T + + + Sbjct: 61 LSVRTNHLDATHGYFNGAALFFRLPGWENLPICVTVIPP----YPQWRVTTPLPTIGEQS 116 Query: 171 YGFGTYVAQNYDELIDHPVEIGDFALATFQAHGVPHDVVITGRVPNLDLARLCEDLKKIC 230 T+ A ++D L+D P EIG+ L F+ G PH++ I G+ N + +L D +KI Sbjct: 117 ---NTFYAADFDTLVDSPFEIGEHQLYHFEVLGKPHELAIWGQ-GNCQVQQLIRDTQKII 172 Query: 231 EAQIAFFEPRSKRAPMDRYVFMTLAVGDGYGGLEHRASTALICARADLPVKGKPEQTDGY 290 + + F P +RYVF+ YGGLEH+ S +LI R D Y Sbjct: 173 QIEAQMF----GGLPYERYVFLLHLFAQAYGGLEHKNSCSLIYQRFGF------RSQDKY 222 Query: 291 RTYLGLCSHEYFHTWNVKRIKPAVFAPYDLRQENYTSLLWLFEGFTSYYDDLFLVRTGVI 350 ++ L +HE+FH WNVKRI+P ++ QENYT LW EG TSYYD L +R G+ Sbjct: 223 ERFIQLLAHEFFHLWNVKRIRPQALEVFNYDQENYTPSLWFCEGTTSYYDLLIPLRAGIY 282 Query: 351 DTDNYLKLVGKTVTGVLRGTGRKKQSVAESSFDAWVKYYRQDENASNAIVSYYTKGSLVA 410 D YL K ++ ++ GRK Q ++ESSFDAW+K YR D N N+ VSYY KG +++ Sbjct: 283 DAKTYLNYWSKEISRLITTPGRKVQPLSESSFDAWIKLYRPDTNTGNSQVSYYLKGEMIS 342 Query: 411 LGLDLTIRTQTRGRRSLDDVMRGLWTRYGRDFYNGKQQGVPEDEILAIMEELSGADLKRF 470 L LDL IR + R +RSLDDVMR +W ++G+ + G +++ A++E ++G DL F Sbjct: 343 LLLDLLIRARYRNQRSLDDVMRQMWQKFGQ-----AEIGYTPEQLQAVIESVAGVDLTDF 397 Query: 471 HDRHIRGTEDVPLEDLLPAFGVAYEANVPADAKPWLGARIGKEGGDAKLAAVYEGGPAML 530 R+I GTE++P L FG+ A + +P+LG ++ E G + V G PA + Sbjct: 398 FARYIDGTEELPFNQYLEPFGLHLVAE--REEEPYLGVKVNTENGREMIKFVEAGSPAQM 455 Query: 531 AGLSAGDKLVAIDGLRVPASGPDGLLARYRLNDTVRIHAFRRDELMEFSVRLKADTAPQV 590 AG+ AGD+L+AI G+++ A L Y+ NDT+++ F +DEL + V+L + Sbjct: 456 AGIDAGDELLAIAGIKITAHQLSDRLKDYQANDTIQVTVFHQDELRTYPVKLGTPRPTKY 515 Query: 591 SLQALAKPVAAARQR-AAWL 609 L A+ P A ++ AAWL Sbjct: 516 QLLAIQNPNATQQENFAAWL 535 >slr0031 [R] COG3975 Predicted protease with the C-terminal PDZ domain Syn Synechocystis Length = 584 Score = 364 bits (934), Expect = e-100, Method: Compositional matrix adjust. Identities = 214/599 (35%), Positives = 317/599 (52%), Gaps = 28/599 (4%) Query: 20 IRYRITSLDPASHLFDVSVTVDAPAAEGQVFSLPAWIPGSYMIREFGKNI--VQLRGECN 77 + Y++ P +H F V + + A P W PGSY++RE+ +++ Q +G N Sbjct: 8 LHYQVAMPTPQTHYFTVDLHIQGFTASVLELKFPVWTPGSYLVREYERHLQDFQAQGLSN 67 Query: 78 GRKVGVKKLDKHTWQAAPC--KGALTLHYQVYAWDLSVRTAHLDRTHGFFNGTSVFLCAH 135 G + +KL K W A C + + + Y++YA +L+VRT HLD +HGFF G ++F Sbjct: 68 GEYLEHQKLGKAHW-AIACGEEENIAISYRIYADELTVRTNHLDYSHGFFTGAALFFYLP 126 Query: 136 GFEQGEHVVELVRPEGEEFKRWRVATAM-SELKAKRYGFGTYVAQNYDELIDHPVEIGDF 194 G + +V PE W +ATA+ + G T+ AQ++D L+D PVE+G Sbjct: 127 GHTHRPLALTVVPPE----PAWAIATALPCKATDSTTGAKTFYAQDFDTLVDSPVEVGIH 182 Query: 195 ALATFQAHGVPHDVVITGRVPNLDLARLCEDLKKICEAQIAFFEPRSKRAPMDRYVFMTL 254 F+ G H V+ G NL+ +L D +KI + F P D Y F+ Sbjct: 183 RDYAFETQGKEHHFVVWGE-SNLNGEQLVRDTEKIIAVEAGLF----GNLPYDHYWFILH 237 Query: 255 AVGDGYGGLEHRASTALICARADLPVKGKPEQTDGYRTYLGLCSHEYFHTWNVKRIKPAV 314 GYGGLEH+ S L R PE+ Y+ +L L +HE+FH WN+KRI+P Sbjct: 238 TSNQGYGGLEHKDSCVLNYDRFGF---RDPEK---YQRFLQLVAHEFFHLWNIKRIRPIA 291 Query: 315 FAPYDLRQENYTSLLWLFEGFTSYYDDLFLVRTGVIDTDNYLKLVGKTVTGVLRGTGRKK 374 +D QENYT LW EG TSYYD L +R + D YLK +GK +T L+ GR Sbjct: 292 LEKFDYDQENYTPSLWFSEGTTSYYDLLIPLRAEIYDRQTYLKNLGKEITRYLKTLGRLV 351 Query: 375 QSVAESSFDAWVKYYRQDENASNAIVSYYTKGSLVALGLDLTIRTQTRGRRSLDDVMRGL 434 Q +AESSFDAW+K YR+D N+ N+ +SYY KG LV L LDL IR + + +RS DDV+R + Sbjct: 352 QPLAESSFDAWIKLYRRDANSDNSQMSYYLKGELVTLMLDLLIRERHQNQRSFDDVLRAM 411 Query: 435 WTRYGRDFYNGKQQGVPEDEILAIMEELSGADLKRFHDRHIRGTEDVPLEDLLPAFGVAY 494 W +GR+ + G +++ A++ ++ DL F ++ T ++PL D L FG+ Sbjct: 412 WQEFGRE-----EIGFTPEQLQAVISRVADTDLTEFFHTYLHTTAELPLNDYLQPFGLVI 466 Query: 495 EANVPADAKPWLGARIGKEGGDAKLAAVYEGGPAMLAGLSAGDKLVAIDGLRVPASGPDG 554 + + D P+LG ++ E G K+ V PA +AG+S D L+AI+G+RV A Sbjct: 467 KP-MQEDLTPYLGIKVKSEAGQEKITFVAAHSPAAMAGISPQDLLLAINGVRVGAEQLSL 525 Query: 555 LLARYRLNDTVRIHAFRRDELMEFSVRLKADTAPQVSLQALAKPVAAARQR-AAWLHEG 612 L Y+ ND +++ F +D L V L + A + + +A P + Q A WL E Sbjct: 526 RLKDYQANDMIQLTVFHQDLLRTVDVVLASPQANRYEVVPIADPSDSQLQNLAGWLGES 584