BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0049.0030.p (456 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value SSO2727 [E] COG0160 4-aminobutyrate aminotransferase and related... 283 5e-76 APE0457 [E] COG0160 4-aminobutyrate aminotransferase and related... 261 3e-69 PH1423 [E] COG0160 4-aminobutyrate aminotransferase and related ... 261 3e-69 PAB0501 [E] COG0160 4-aminobutyrate aminotransferase and related... 254 2e-67 TVN0024 [E] COG0160 4-aminobutyrate aminotransferase and related... 249 9e-66 >SSO2727 [E] COG0160 4-aminobutyrate aminotransferase and related aminotransferases Sso Sulfolobus solfataricus Length = 440 Score = 283 bits (725), Expect = 5e-76, Method: Compositional matrix adjust. Identities = 168/457 (36%), Positives = 263/457 (57%), Gaps = 19/457 (4%) Query: 2 IEAELESLNFADAPKMVTPTYPGPKTAAALELSARTESMARGGGR-MPIAMDQAFGVTFK 60 +E L+S + +AP ++ T PG K+ L+ E+ A + IA+D+A G T Sbjct: 1 MEENLDS-SVLEAP-IINVTPPGSKSLKLLKDQEEYETSAINYPKYFKIAIDKAQGSTVT 58 Query: 61 DPDGNTFIDLSAGVGVSSVGRCNPRVVEAIRKQSESLMHSMEVNSSKRTELAAKISEIMP 120 D DGN +IDL G+ V ++G NP V + +++Q E + H++EV + R + K+ + Sbjct: 59 DVDGNVYIDLVTGISVVNLGHNNPFVRKRVQEQLEKVWHTLEVPTEIRVNFSKKLLSTL- 117 Query: 121 DGLRGDCITFFTQGGSDALEAAVKFAKRVTGRHQIIAFHGGYHGIWNASNALTTGTAYRK 180 G+R + FT G+DA+EAAVK A+ +TG+ IIAF G YHGI + LT +++ Sbjct: 118 -GMRAKLL--FTTTGADAVEAAVKIARFITGKKTIIAFEGSYHGITAGTLGLTGANRFKE 174 Query: 181 GFGPFMGG-VIHAPYPYAYRFPFDTSHKSAEQIAGEYVDYLLNTPYTAADDVAAVIVEPV 239 F PF V+ PYPY YR PF + +DY ++ P DVA ++VEP+ Sbjct: 175 -FQPFFDDRVVKFPYPYPYRCPFKDCLNETLSL----LDYAMSNPGYLGGDVAGILVEPI 229 Query: 240 QGEGGYVPPSPEFLQILRKACDRSGALLIVDEVQAGAGRTGKMWAVEHSGVKPDMLTFGK 299 QGEGGYV P FL+ L++ ++ LIVDEVQ G GRTGKMWA + ++PD++T K Sbjct: 230 QGEGGYVVPPKGFLKGLKELAEKYSVPLIVDEVQTGVGRTGKMWAYQWENIEPDIVTISK 289 Query: 300 GIGGDMPMAGLVMRSDLAAKIPDGSQPNTFAANSISAAVALTNISILQDPRLDLVNRAHT 359 IG +P++ + R D K+P G T+ N + A L ++ ++ ++++R Sbjct: 290 AIGEGIPVSMVAYREDF-DKLPTGFHLGTYRGNPLGLAAGLASLEFIESH--NILSRVER 346 Query: 360 LGLEAQERIRSFNSPWVGEVRGRGLMIGIELVENRETREPLSREKLGKLMDYVVGHGVLM 419 LG +A E ++ +P VG++RG G MIGIELV ++++EP S E +++ + G+L+ Sbjct: 347 LGRKALELLKEVQNPHVGDIRGLGFMIGIELV--KDSKEPWS-EGTKVVIERALKRGLLV 403 Query: 420 IPCGRYTNVMRVMPSLTIPRSLMFKGLDIFGAGLASL 456 GR+ NV+R+MP LTIP SL+ + ++I L +L Sbjct: 404 YKAGRWDNVIRLMPPLTIPESLLDRAIEILKIILNTL 440 >APE0457 [E] COG0160 4-aminobutyrate aminotransferase and related aminotransferases Ape Aeropyrum pernix Length = 452 Score = 261 bits (666), Expect = 3e-69, Method: Compositional matrix adjust. Identities = 163/447 (36%), Positives = 249/447 (55%), Gaps = 22/447 (4%) Query: 13 DAPKMVTPTYPGPKTAAALELSART--ESMARGGGRMPIAMDQAFGVTFKDPDGNTFIDL 70 DAP++V PGP+ LE R +S R P+ + + +G +D DGN +ID Sbjct: 4 DAPRIVVEP-PGPRAREVLERDERVIMQSFTRW---YPLVVKRGYGAVVEDVDGNRYIDF 59 Query: 71 SAGVGVSSVGRCNPRVVEAIRKQSESLMHS--MEVNSSKRTELAAKISEIMPDGLRGDCI 128 +AG+ V +VG +PRVVEA+++Q E +H + + A +++ +P + G Sbjct: 60 NAGIAVLNVGHNHPRVVEAVKRQLERFLHYSLTDFYYEEAVSAAERLARSVP--ISGGAK 117 Query: 129 TFFTQGGSDALEAAVKFAKRVT--GRHQIIAFHGGYHG-IWNASNALTTGTAYRKGFGPF 185 TFFT G++++EA++K + R II+F GG+HG + A +A + +R F P Sbjct: 118 TFFTNSGAESIEASIKVVRAFFRGTRPYIISFLGGFHGRTYGAMSASASKPVHRARFYPL 177 Query: 186 MGGVIHAPYPYAYRFPF-DTSHKSAEQIAGEYVDYLLNTPYTAADDVAAVIVEPVQGEGG 244 + G IHAPYP YR PF ++ + A Y++ + + +VAA + EP+QGEGG Sbjct: 178 VPGFIHAPYPDPYRCPFPGLEGEACGEAAVSYIEDYIFSKLVDPGEVAAFLFEPIQGEGG 237 Query: 245 YVPPSPEFLQILRKACDRSGALLIVDEVQAGAGRTGKMWAVEHSGVKPDMLTFGKGIGGD 304 YV P FL L+K + G LLI DEVQ G RTG+M+AVEH GV+PD++ K +GG Sbjct: 238 YVVPPDSFLPSLQKLARKHGILLIADEVQTGFARTGRMFAVEHWGVEPDVMALAKAMGGG 297 Query: 305 MPMAGLVMRSDLAAKIPDGSQPNTFAANSISAAVALTNISILQDPRLDLVNRAHTLGLEA 364 +P+ V RS++ + +P GS NTF N ++ A + +++ R L R+ LG +A Sbjct: 298 LPLGAAVGRSEVMS-LPRGSHANTFGGNPVALAAFNAVMDVIEGER--LWERSQRLGEKA 354 Query: 365 QERIRSFNSPW--VGEVRGRGLMIGIELVENRETREPLSREKLGKLMDYVVGHGVLMIPC 422 + + VG VRG+GLMIG+ELV + TREP +E L ++D G+L+I Sbjct: 355 LKILGEAAEELSIVGHVRGKGLMIGVELVRDENTREP-HKEALAWVLDRSFKRGLLVIGA 413 Query: 423 GRYTNVMRVMPSLTIPRSLMFKGLDIF 449 G + +R+ P LTI L +GL+I Sbjct: 414 G--VSAVRIAPPLTIEEELFDRGLEIL 438 >PH1423 [E] COG0160 4-aminobutyrate aminotransferase and related aminotransferases Pho Pyrococcus horikoshii Length = 454 Score = 261 bits (666), Expect = 3e-69, Method: Compositional matrix adjust. Identities = 158/437 (36%), Positives = 248/437 (56%), Gaps = 19/437 (4%) Query: 23 PGPKTAAALELSAR-TESMARGGGRMPIAMDQAFGVTFKDPDGNTFIDLSAGVGVSSVGR 81 PGPK +E + + + +++A GV + D DGN +D S+G+GV +VG Sbjct: 11 PGPKARKVIEEHHKYMATTTNDPNEYFLVIERAEGVYWIDVDGNVLLDFSSGIGVMNVGL 70 Query: 82 CNPRVVEAIRKQSESLMHS--MEVNSSKRTELAAKISEIMPDGLRGDCITFFTQGGSDAL 139 NP+V+EAI+KQ + ++H+ + + + ELA K+ EI P + F + G++A Sbjct: 71 RNPKVIEAIKKQLDLVLHAAGTDYYNPYQVELAKKLVEIAPGDIERKV--FLSNSGTEAN 128 Query: 140 EAAVKFAKRVTGRHQIIAFHGGYHGIWNASNALTTGT-AYRKGFGPFMGGVIHAPYPYAY 198 EAA+K AK T R IAF G +HG + + +LT R P M GV+H PYP Y Sbjct: 129 EAALKIAKWSTNRKMFIAFIGAFHGRTHGTMSLTASKPVQRSRMFPTMPGVVHVPYPNPY 188 Query: 199 RFPFDTS-HKSAEQIAGEYVDYL---LNTPYTAADDVAAVIVEPVQGEGGYVPPSPEFLQ 254 R P+ +++ +++ +DY+ L Y A++VA + EP+QGEGGYV P F + Sbjct: 189 RNPWGIDGYENPDELINRVIDYIEEYLFEHYVPAEEVAGIFFEPIQGEGGYVVPPKNFFK 248 Query: 255 ILRKACDRSGALLIVDEVQAGAGRTGKMWAVEHSGVKPDMLTFGKGIGGDMPMAGLVMRS 314 L+K D+ G LLI DEVQ G GRTG+MWA+EH + PD++T K +GG +P+ + R+ Sbjct: 249 ELKKLADKHGILLIDDEVQMGMGRTGRMWAIEHFDIVPDIVTVAKALGGGIPIGATIFRA 308 Query: 315 DLAAKIPDGSQPNTFAANSISAAVALTNISILQDPRLDLVNRAHTLGLEAQERIRSFNSP 374 DL + G NTF N+++AA AL I LQ+ L+ A L +ER+ Sbjct: 309 DLDFGV-SGVHSNTFGGNTVAAAAALAVIEELQN---GLIENAQKLEPLFRERLEEMKEK 364 Query: 375 W--VGEVRGRGLMIGIELVENRETREPLSREKLGKLMDYVVGHGVLMIPCGRYTNVMRVM 432 + +G+VRG GL G+E V++R+T+E ++E+ G+++ + G+ ++ CG+ + +R++ Sbjct: 365 YEIIGDVRGLGLAWGVEFVKDRKTKEYATKER-GEIVVEALKRGLALLGCGK--SAIRLI 421 Query: 433 PSLTIPRSLMFKGLDIF 449 P L I GLDIF Sbjct: 422 PPLIISEEEAKMGLDIF 438 >PAB0501 [E] COG0160 4-aminobutyrate aminotransferase and related aminotransferases Pab Pyrococcus abyssi Length = 454 Score = 254 bits (650), Expect = 2e-67, Method: Compositional matrix adjust. Identities = 158/437 (36%), Positives = 247/437 (56%), Gaps = 19/437 (4%) Query: 23 PGPKTAAALELSAR-TESMARGGGRMPIAMDQAFGVTFKDPDGNTFIDLSAGVGVSSVGR 81 PGPK +E + + + +++A GV + D DGN +D S+G+GV +VG Sbjct: 11 PGPKARKVIEEHHKYMATTTNDPNEYFLVIEKAEGVYWIDVDGNVILDFSSGIGVMNVGL 70 Query: 82 CNPRVVEAIRKQSESLMHS--MEVNSSKRTELAAKISEIMPDGLRGDCITFFTQGGSDAL 139 NP+V+EAI+KQ + ++H+ + + + ELA K+ EI P + F + G++A Sbjct: 71 RNPKVIEAIKKQLDLVLHAAGTDYYNPYQVELAKKLIEIAPGDMERKV--FLSNSGTEAN 128 Query: 140 EAAVKFAKRVTGRHQIIAFHGGYHGIWNASNALTTGT-AYRKGFGPFMGGVIHAPYPYAY 198 EAA+K AK T R IAF G +HG + + +LT +R P M GV H PYP Y Sbjct: 129 EAALKIAKWSTNRKMFIAFIGAFHGRTHGTMSLTASKPVHRSRMFPTMPGVEHVPYPNPY 188 Query: 199 RFPFDTS-HKSAEQIAG---EYVDYLLNTPYTAADDVAAVIVEPVQGEGGYVPPSPEFLQ 254 R P+ +++ +++ EY++ L Y A++VA + EP+QGEGGYV P F + Sbjct: 189 RNPWGIDGYENPDELINRVIEYIEDYLFEHYVPAEEVAGIFFEPIQGEGGYVVPPKNFFK 248 Query: 255 ILRKACDRSGALLIVDEVQAGAGRTGKMWAVEHSGVKPDMLTFGKGIGGDMPMAGLVMRS 314 L+K D+ G LLI DEVQ G GRTG+MWA+EH V PD++T K +GG +P+ + R+ Sbjct: 249 ELKKLADKHGILLIDDEVQMGMGRTGRMWAIEHFDVVPDIITVAKALGGGIPIGATIFRA 308 Query: 315 DLAAKIPDGSQPNTFAANSISAAVALTNISILQDPRLDLVNRAHTLGLEAQERIRSFNSP 374 DL + G NTF N+++AA AL I LQ+ L+ A L +ER+ Sbjct: 309 DLDFGV-SGVHSNTFGGNAVAAAAALAVIEELQN---GLIENAQKLEPLFRERLEEMKEK 364 Query: 375 W--VGEVRGRGLMIGIELVENRETREPLSREKLGKLMDYVVGHGVLMIPCGRYTNVMRVM 432 + +G+VRG GL G+E V++R+T+E ++E+ +++ + G+ ++ CG+ + +R++ Sbjct: 365 YEIIGDVRGLGLAWGVEFVKDRKTKEYATKER-NEIVVEALKRGLALLGCGK--SAIRLI 421 Query: 433 PSLTIPRSLMFKGLDIF 449 P L I GLDIF Sbjct: 422 PPLIISEEEAKIGLDIF 438 >TVN0024 [E] COG0160 4-aminobutyrate aminotransferase and related aminotransferases Tvo Thermoplasma volcanium Length = 449 Score = 249 bits (636), Expect = 9e-66, Method: Compositional matrix adjust. Identities = 145/462 (31%), Positives = 251/462 (54%), Gaps = 26/462 (5%) Query: 1 MIEAELESLNFADAPKMVTPTYPGPKTAAALELSARTESMARGGGRMPIAMDQAFGVTFK 60 M++ EL + VTP PGP+ +EL+ + +AR +P+ GV + Sbjct: 1 MMQEELNGIKIK-----VTP--PGPEAKKIIELNDKY--LARSTQSLPVVGKLGKGVYVE 51 Query: 61 DPDGNTFIDLSAGVGVSSVGRCNPRVVEAIRKQSESLMH--SMEVNSSKRTELAAKISEI 118 D DGN ++D ++G+ V+++G +P V + + +Q L H + + + A + E+ Sbjct: 52 DVDGNVYLDFASGISVTNLGHLDPYVTQKVEEQLHKLWHFPGTDFYTEMQVLAAKSLIEV 111 Query: 119 MPDGLRGDCITFFTQGGSDALEAAVKFAKRVTGRHQIIAFHGGYHGIWNASNALTTGT-A 177 P FFT G++++EAA+K AK T R + I F G +HG S + T Sbjct: 112 TPGKFNKKV--FFTNSGTESVEAAIKIAKSYTHRERFIGFIGAFHGRTQGSLSFTASKPI 169 Query: 178 YRKGFGPFMGGVIHAPYPYAYRFPFDTS-HKSAEQIAGEYVDYL---LNTPYTAADDVAA 233 + KGF P M GV H P+P YR PF+ ++ +++ +DY+ L Y +DVA Sbjct: 170 HHKGFFPSMPGVEHVPFPNPYRNPFNIDGYEEPDELVNRVIDYIETYLLKTYVPPEDVAG 229 Query: 234 VIVEPVQGEGGYVPPSPEFLQILRKACDRSGALLIVDEVQAGAGRTGKMWAVEHSGVKPD 293 ++ EP+QGEGGY+ P F + LRK D+ L++DEVQ+G GRTGK +A EH GV+PD Sbjct: 230 ILAEPIQGEGGYIVPPMNFFKELRKLADKYHIPLLIDEVQSGFGRTGKFFASEHFGVEPD 289 Query: 294 MLTFGKGIGGDMPMAGLVMRSDLAAKIPDGSQPNTFAANSISAAVALTNISILQDPRLDL 353 ++T K I +PM VM+ ++ +G NTF N I++A + I ++ +L+ Sbjct: 290 VITLAKSIASGIPMGAAVMKEEMNFS-ENGLHSNTFGGNLIASAACVATIDEMK--KLNA 346 Query: 354 VNRAHTLGLEAQERIRSFNSPW--VGEVRGRGLMIGIELVENRETREPLSREKLGKLMDY 411 V A G ++R+ + + +G+VRG GLM+ I+ V++R T+EP S+ + +++ Sbjct: 347 VENAAKQGAYMKKRLVELQNKYNEIGDVRGLGLMLAIDFVKDRRTKEPNSKLR-NDVINN 405 Query: 412 VVGHGVLMIPCGRYTNVMRVMPSLTIPRSLMFKGLDIFGAGL 453 +G++++ G ++ +R++P L I + + +G+++ + Sbjct: 406 AFKNGLILLSTG--SSAIRIIPPLIITQEQVDEGIEVLDKAI 445