BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0045.0044.p (423 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value ZynfM [GEPR] COG0477 Permeases of the major facilitator superfam... 336 6e-92 ECs2302 [GEPR] COG0477 Permeases of the major facilitator superf... 335 9e-92 ynfM [GEPR] COG0477 Permeases of the major facilitator superfami... 335 9e-92 RSc3069 [GEPR] COG0477 Permeases of the major facilitator superf... 320 3e-87 STM1486 [GEPR] COG0477 Permeases of the major facilitator superf... 317 3e-86 >ZynfM [GEPR] COG0477 Permeases of the major facilitator superfamily EcZ Escherichia coli O157:H7 EDL933 Length = 417 Score = 336 bits (862), Expect = 6e-92, Method: Compositional matrix adjust. Identities = 183/414 (44%), Positives = 256/414 (61%), Gaps = 3/414 (0%) Query: 9 ARAANAD-APVTPAQTAPEAAPRG-ATRGSAAYARIVLALFFSGFATFSLLYCVQPLLPI 66 +R D AP + + P RG+ + R+ LALF +G ATF+LLYCVQP+LP+ Sbjct: 2 SRTTTVDGAPASDTDKQSISQPNQFIKRGTPQFMRVTLALFSAGLATFALLYCVQPILPV 61 Query: 67 FAQEFGIGAASASLALSLSTGLLAVSIVLAGMLSERYGRRELMFASLAMAACCNLAAGVA 126 +QEFG+ A++S++LS+ST +LA+ ++ G LS+ GR+ +M +L +A+ C L + + Sbjct: 62 LSQEFGLTPANSSISLSISTAMLAIGLLFTGPLSDAIGRKPVMVTALLLASICTLLSTMM 121 Query: 127 PDWHLLLLARTLEGIALGGVPAVAMAYLAEEIDAAGLGFAMGLYVGGNAFGGMAGRVAMS 186 WH +L+ R L G++L GV AV M YL+EEI + + F+MGLY+ GN+ GGM+GR+ Sbjct: 122 TSWHGILIMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLISG 181 Query: 187 VLAEHLGWRAGMLIIGALDLALAVAFVMMLPASRHFVRNSSMRLADHFALWRGHLRHARL 246 V + WR + IG LA A+ F +LP SRHF R +S+R F +R H R L Sbjct: 182 VFTDFFNWRIALAAIGCFALASALMFWKILPESRHF-RPTSLRPKSLFINFRLHWRDRGL 240 Query: 247 PLCFAIAALNMGVFVTSYNYAGFRLMSPPFSLSATVTGLIFSAYLFGMLSSSWAGALADR 306 PL FA L MG FVT +NY G+RLM P+ +S V GL+ AYL G SS AG + R Sbjct: 241 PLLFAXGFLLMGSFVTLFNYIGYRLMLSPWHVSQAVVGLLSLAYLTGTWSSPKAGTMTTR 300 Query: 307 YGRAPLVAAGIGISCLGLLLTCTSSLLLVIGGIVLLTIGFFTTHSAASSWVGRMAREGKG 366 YGR P++ G+ GLL+T SSL L+ G++L + GFF HS ASSW+G A+ KG Sbjct: 301 YGRGPVMLFSTGVMLFGLLMTLFSSLWLIFAGMLLFSAGFFAAHSVASSWIGPRAKRAKG 360 Query: 367 HAASLYLLAYYLGGSILGSVGGWFWEHAGWNAVAGFMLLQVMGAAWAARRLWRQ 420 A+SLYL +YYLG SI G++GG FW + GWN V F+ L ++ A RL R+ Sbjct: 361 QASSLYLFSYYLGSSIAGTLGGVFWHNYGWNGVGAFIALMLVIALLVGTRLHRR 414 >ECs2302 [GEPR] COG0477 Permeases of the major facilitator superfamily Ecs Escherichia coli O157:H7 Length = 417 Score = 335 bits (860), Expect = 9e-92, Method: Compositional matrix adjust. Identities = 183/414 (44%), Positives = 256/414 (61%), Gaps = 3/414 (0%) Query: 9 ARAANAD-APVTPAQTAPEAAPRG-ATRGSAAYARIVLALFFSGFATFSLLYCVQPLLPI 66 +R D AP + + P RG+ + R+ LALF +G ATF+LLYCVQP+LP+ Sbjct: 2 SRTTTVDGAPASDTDKQSISQPNQFIKRGTPQFMRVTLALFSAGLATFALLYCVQPILPV 61 Query: 67 FAQEFGIGAASASLALSLSTGLLAVSIVLAGMLSERYGRRELMFASLAMAACCNLAAGVA 126 +QEFG+ A++S++LS+ST +LA+ ++ G LS+ GR+ +M +L +A+ C L + + Sbjct: 62 LSQEFGLTPANSSISLSISTAMLAIGLLFTGPLSDAIGRKPVMVTALLLASICTLLSTMM 121 Query: 127 PDWHLLLLARTLEGIALGGVPAVAMAYLAEEIDAAGLGFAMGLYVGGNAFGGMAGRVAMS 186 WH +L+ R L G++L GV AV M YL+EEI + + F+MGLY+ GN+ GGM+GR+ Sbjct: 122 TSWHGILIMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLISG 181 Query: 187 VLAEHLGWRAGMLIIGALDLALAVAFVMMLPASRHFVRNSSMRLADHFALWRGHLRHARL 246 V + WR + IG LA A+ F +LP SRHF R +S+R F +R H R L Sbjct: 182 VFTDFFNWRIALAAIGCFALASALMFWKILPESRHF-RPTSLRPKSLFINFRLHWRDRGL 240 Query: 247 PLCFAIAALNMGVFVTSYNYAGFRLMSPPFSLSATVTGLIFSAYLFGMLSSSWAGALADR 306 PL FA L MG FVT +NY G+RLM P+ +S V GL+ AYL G SS AG + R Sbjct: 241 PLLFAEGFLLMGSFVTLFNYIGYRLMLSPWHVSQAVVGLLSLAYLTGTWSSPKAGTMTTR 300 Query: 307 YGRAPLVAAGIGISCLGLLLTCTSSLLLVIGGIVLLTIGFFTTHSAASSWVGRMAREGKG 366 YGR P++ G+ GLL+T SSL L+ G++L + GFF HS ASSW+G A+ KG Sbjct: 301 YGRGPVMLFSTGVMLFGLLMTLFSSLWLIFAGMLLFSAGFFAAHSVASSWIGPRAKRAKG 360 Query: 367 HAASLYLLAYYLGGSILGSVGGWFWEHAGWNAVAGFMLLQVMGAAWAARRLWRQ 420 A+SLYL +YYLG SI G++GG FW + GWN V F+ L ++ A RL R+ Sbjct: 361 QASSLYLFSYYLGSSIAGTLGGVFWHNYGWNGVGAFIALMLVIALLVGTRLHRR 414 >ynfM [GEPR] COG0477 Permeases of the major facilitator superfamily Eco Escherichia coli K12 Length = 417 Score = 335 bits (860), Expect = 9e-92, Method: Compositional matrix adjust. Identities = 183/414 (44%), Positives = 256/414 (61%), Gaps = 3/414 (0%) Query: 9 ARAANAD-APVTPAQTAPEAAPRG-ATRGSAAYARIVLALFFSGFATFSLLYCVQPLLPI 66 +R D AP + + P RG+ + R+ LALF +G ATF+LLYCVQP+LP+ Sbjct: 2 SRTTTVDGAPASDTDKQSISQPNQFIKRGTPQFMRVTLALFSAGLATFALLYCVQPILPV 61 Query: 67 FAQEFGIGAASASLALSLSTGLLAVSIVLAGMLSERYGRRELMFASLAMAACCNLAAGVA 126 +QEFG+ A++S++LS+ST +LA+ ++ G LS+ GR+ +M +L +A+ C L + + Sbjct: 62 LSQEFGLTPANSSISLSISTAMLAIGLLFTGPLSDAIGRKPVMVTALLLASICTLLSTMM 121 Query: 127 PDWHLLLLARTLEGIALGGVPAVAMAYLAEEIDAAGLGFAMGLYVGGNAFGGMAGRVAMS 186 WH +L+ R L G++L GV AV M YL+EEI + + F+MGLY+ GN+ GGM+GR+ Sbjct: 122 TSWHGILIMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLISG 181 Query: 187 VLAEHLGWRAGMLIIGALDLALAVAFVMMLPASRHFVRNSSMRLADHFALWRGHLRHARL 246 V + WR + IG LA A+ F +LP SRHF R +S+R F +R H R L Sbjct: 182 VFTDFFNWRIALAAIGCFALASALMFWKILPESRHF-RPTSLRPKTLFINFRLHWRDRGL 240 Query: 247 PLCFAIAALNMGVFVTSYNYAGFRLMSPPFSLSATVTGLIFSAYLFGMLSSSWAGALADR 306 PL FA L MG FVT +NY G+RLM P+ +S V GL+ AYL G SS AG + R Sbjct: 241 PLLFAEGFLLMGSFVTLFNYIGYRLMLSPWHVSQAVVGLLSLAYLTGTWSSPKAGTMTTR 300 Query: 307 YGRAPLVAAGIGISCLGLLLTCTSSLLLVIGGIVLLTIGFFTTHSAASSWVGRMAREGKG 366 YGR P++ G+ GLL+T SSL L+ G++L + GFF HS ASSW+G A+ KG Sbjct: 301 YGRGPVMLFSTGVMLFGLLMTLFSSLWLIFAGMLLFSAGFFAAHSVASSWIGPRAKRAKG 360 Query: 367 HAASLYLLAYYLGGSILGSVGGWFWEHAGWNAVAGFMLLQVMGAAWAARRLWRQ 420 A+SLYL +YYLG SI G++GG FW + GWN V F+ L ++ A RL R+ Sbjct: 361 QASSLYLFSYYLGSSIAGTLGGVFWHNYGWNGVGAFIALMLVIALLVGTRLHRR 414 >RSc3069 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 428 Score = 320 bits (821), Expect = 3e-87, Method: Compositional matrix adjust. Identities = 211/419 (50%), Positives = 261/419 (62%), Gaps = 2/419 (0%) Query: 4 LSDPAARAANA--DAPVTPAQTAPEAAPRGATRGSAAYARIVLALFFSGFATFSLLYCVQ 61 ++ PA+ +A A VT A P R RGS Y R LALF +GF+TFSLLYCVQ Sbjct: 1 MNAPASSSATPVPTAHVTHATMEPADPARWLVRGSPGYRRANLALFAAGFSTFSLLYCVQ 60 Query: 62 PLLPIFAQEFGIGAASASLALSLSTGLLAVSIVLAGMLSERYGRRELMFASLAMAACCNL 121 PL+P+ +FG+ A SL LS +T LLA +I+ AG+LSE R+ LM SL +++ + Sbjct: 61 PLMPLLGHDFGLSPAQTSLVLSATTMLLAFAILFAGLLSESIHRKTLMGVSLVLSSALTV 120 Query: 122 AAGVAPDWHLLLLARTLEGIALGGVPAVAMAYLAEEIDAAGLGFAMGLYVGGNAFGGMAG 181 AA V P W LL R + G+ LGGVPAVAMAYLAEE+ GLG AMGLYVGG AFGGMAG Sbjct: 121 AAAVLPGWQGLLATRAVLGVVLGGVPAVAMAYLAEEVHPQGLGMAMGLYVGGTAFGGMAG 180 Query: 182 RVAMSVLAEHLGWRAGMLIIGALDLALAVAFVMMLPASRHFVRNSSMRLADHFALWRGHL 241 RV ++A++ GWR M IGAL L A+AF +LP SR F + LAD F HL Sbjct: 181 RVLTGMVADYAGWRVAMGFIGALCLLAALAFAWLLPPSRRFAPRRGVALADLFDTLAEHL 240 Query: 242 RHARLPLCFAIAALNMGVFVTSYNYAGFRLMSPPFSLSATVTGLIFSAYLFGMLSSSWAG 301 R L FA+A L MG FVT YNYA +RL+S P++LS + G IF YL G+ +S+W G Sbjct: 241 REPGLRALFAMAFLLMGGFVTIYNYASYRLLSAPYALSHSAVGAIFMVYLLGIGASTWFG 300 Query: 302 ALADRYGRAPLVAAGIGISCLGLLLTCTSSLLLVIGGIVLLTIGFFTTHSAASSWVGRMA 361 LADR+GR ++ AG G+L+T L LVIGGI LLT GFF H+ AS WVGR A Sbjct: 301 RLADRHGRGRVLLAGTAAMSAGVLMTLAMPLGLVIGGIALLTFGFFGAHAVASGWVGRRA 360 Query: 362 REGKGHAASLYLLAYYLGGSILGSVGGWFWEHAGWNAVAGFMLLQVMGAAWAARRLWRQ 420 R KG AA+LYLLAYYLG SI G+ GG + GW V + + A A LWR+ Sbjct: 361 RRAKGQAAALYLLAYYLGSSIAGTAGGKLYARWGWPGVVALVTAMLACALLTAAWLWRR 419 >STM1486 [GEPR] COG0477 Permeases of the major facilitator superfamily Sty Salmonella typhimurium LT2 Length = 417 Score = 317 bits (812), Expect = 3e-86, Method: Compositional matrix adjust. Identities = 186/404 (46%), Positives = 256/404 (63%), Gaps = 2/404 (0%) Query: 15 DAPVTPAQTAPEAAP-RGATRGSAAYARIVLALFFSGFATFSLLYCVQPLLPIFAQEFGI 73 DA + + P + RG+A + R+ LALF +G ATF+LLYCVQP+LP+ +QEFG+ Sbjct: 9 DATASDIDEQRHSQPVQFIKRGTAPFMRVTLALFSAGLATFALLYCVQPILPVLSQEFGV 68 Query: 74 GAASASLALSLSTGLLAVSIVLAGMLSERYGRRELMFASLAMAACCNLAAGVAPDWHLLL 133 AS+S++LS+ST +LA+ ++ G LS+ GR+ +M +L +A+CC L + + WH +L Sbjct: 69 SPASSSVSLSISTAMLAIGLLFTGPLSDAIGRKPVMVTALLLASCCTLLSTMMTSWHGIL 128 Query: 134 LARTLEGIALGGVPAVAMAYLAEEIDAAGLGFAMGLYVGGNAFGGMAGRVAMSVLAEHLG 193 + R L G++L GV AV M YL+EEI + + F+MGLY+ GN+ GGM+GR+ V+ + Sbjct: 129 IMRALIGLSLSGVAAVGMTYLSEEIHPSFVAFSMGLYISGNSIGGMSGRLLSGVMTDFFN 188 Query: 194 WRAGMLIIGALDLALAVAFVMMLPASRHFVRNSSMRLADHFALWRGHLRHARLPLCFAIA 253 WR + IG LA A+ F +LPAS+HF R +S+R F +R H R LPL FA Sbjct: 189 WRIALAAIGCFALASALMFWKILPASQHF-RPTSLRPKTLFINFRLHWRDRGLPLLFAEG 247 Query: 254 ALNMGVFVTSYNYAGFRLMSPPFSLSATVTGLIFSAYLFGMLSSSWAGALADRYGRAPLV 313 L MG FVT +NY G+RLM P+ LS V GL+ AYL G SS AGA+ RYGR P++ Sbjct: 248 FLLMGAFVTLFNYIGYRLMLSPWELSQAVVGLLSVAYLTGTWSSPKAGAMTSRYGRGPVM 307 Query: 314 AAGIGISCLGLLLTCTSSLLLVIGGIVLLTIGFFTTHSAASSWVGRMAREGKGHAASLYL 373 + GLLLT +SL L+ G++L + GFF HS ASSW+G AR KG A+SLYL Sbjct: 308 LFSTAVMLGGLLLTLFTSLWLIFAGMLLFSAGFFAAHSVASSWIGPRARRAKGQASSLYL 367 Query: 374 LAYYLGGSILGSVGGWFWEHAGWNAVAGFMLLQVMGAAWAARRL 417 +YYLG SI G++GG FW GWN V GF+ L ++ A RL Sbjct: 368 FSYYLGSSIAGTLGGVFWHSYGWNGVGGFIALMLVLAILVGTRL 411