BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0042.0315.p (385 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PA3532 [GEPR] COG0477 Permeases of the major facilitator superfa... 175 1e-43 BMEI0267 [GEPR] COG0477 Permeases of the major facilitator super... 165 2e-40 DR2502 [GEPR] COG0477 Permeases of the major facilitator superfa... 158 2e-38 ybjJ [GEPR] COG0477 Permeases of the major facilitator superfami... 154 2e-37 ECs0925 [GEPR] COG0477 Permeases of the major facilitator superf... 154 3e-37 >PA3532 [GEPR] COG0477 Permeases of the major facilitator superfamily Pae Pseudomonas aeruginosa Length = 383 Score = 175 bits (444), Expect = 1e-43, Method: Compositional matrix adjust. Identities = 130/350 (37%), Positives = 193/350 (55%), Gaps = 10/350 (2%) Query: 19 KIAIPFLFLLLGVVFSTWAARIPAIRDQLQLDAATLALVLLCGGIGAVGSFPLAAWITGH 78 ++A + F + G+V RIPA+++Q QLD L LL G+GA+ +FPL+ ++ Sbjct: 10 RLACIYFFAMAGLVIGNLMGRIPALKEQTQLDERALGQALLGVGVGALTAFPLSGFLVQR 69 Query: 79 YGARHSSLYAGLALLFSLPLLALAPGLWTLMAVCTLYGAASSCFDVAINALGAQAEREAG 138 G+R + L +L PLL L+ G W L + G + + DVA+N ER G Sbjct: 70 IGSRSVVIGGCLIMLLVFPLLGLSQGWWQLALAFYVLGVSFAGMDVAMNIQAVDVERLLG 129 Query: 139 RPIMSMLHGWFCVGTFSGALVASAVAGLGVAPLWHFLLAAA--LLAWPLYASCQALPDDR 196 +P MSMLHG + +G GAL A+A+A G+ P WHFL+ A LL+ P + PD Sbjct: 130 KPCMSMLHGMYSLGCLVGALSAAALA--GLTPFWHFLILTALGLLSLPFFVRALLPPDPS 187 Query: 197 PQYDPQRQLFALPHGHLVVLGVIAFCGAIVEGSVADWSGIYMKDHIGASDGATPLAYAAF 256 + F LP L+ LG++ C + EG VADWS +++ + AS+ L +AAF Sbjct: 188 KAGARKGGGFTLPPRALLGLGLLILCAFVSEGGVADWSALFLHSVLDASERVAALGFAAF 247 Query: 257 AGMMLVMRMVGDGLKARY-DARRVVSIGTLVATGGMALAVTAQGMTPAILGFAIAGAGVA 315 + M+V R+ GD L+ R DA + +G+L AT GM +A+ + +I GF + G G++ Sbjct: 248 SAAMVVGRLFGDRLRGRIDDAPLLRGLGSL-ATLGMLVALFSPWPALSIAGFGVVGLGLS 306 Query: 316 AVFPFVFSAAGRHGS----TALAAVATLGYSGSLIGPPVFGFLAHGWGLQ 361 + P V SAAG +AAV+T+GY G L+GPP+ G LAH GL+ Sbjct: 307 VMVPIVISAAGNQPGIDPVIGVAAVSTVGYGGLLMGPPLIGLLAHEIGLR 356 >BMEI0267 [GEPR] COG0477 Permeases of the major facilitator superfamily Bme Brucella melitensis Length = 397 Score = 165 bits (417), Expect = 2e-40, Method: Compositional matrix adjust. Identities = 114/358 (31%), Positives = 184/358 (51%), Gaps = 24/358 (6%) Query: 18 RKIAIPFLFLLLGVVFSTWAARIPAIRDQLQLDAATLALVLLCGGIGAVGSFPLAAWITG 77 +IA+ LFL+ G +F WA +IP ++L LD+A + L++L G+G++ P+A ++ Sbjct: 21 ERIAVALLFLMNGYIFGGWAPKIPEFAERLGLDSAGMGLMILVCGLGSLAMMPVAGALSA 80 Query: 78 HYGARHSSLYAGLALLFSLPLLALAPGLWTLMAVCTLYGAASSCFDVAINALGAQAEREA 137 H G+ LA + +L ++ L P + T + V +G + DV++NA E++ Sbjct: 81 HRGSGIVVRIFALAFIPALLIITLVPNVVTAVIVMLYFGGTMAAMDVSMNANAVAVEKKM 140 Query: 138 GRPIMSMLHGWFCVGTFSGALVASAVAGLGVAPLWHF------LLAAALL---AWPLYAS 188 R IMS H ++ + G L+ +A G +A ++AA +L AWP Sbjct: 141 RRAIMSSCHAFWSL----GGLIGAATGGFLIAQFGSIVHALVTMIAATILIIVAWP---- 192 Query: 189 CQALPDDRPQY-DPQRQLFALPHGHLV-VLGVIAFCGAIVEGSVADWSGIYMKDHIGASD 246 +PD + D ++Q ALP L ++GV+A + EG++ DW +M+ +GAS Sbjct: 193 -SIIPDTEHHHPDGEKQKLALPRNPLPWLVGVMALFSMVPEGAILDWGAYHMRQDLGASV 251 Query: 247 GATPLAYAAFAGMMLVMRMVGDGLKARYDARRVVSIGTLVATGGMALAVTAQGMTPAILG 306 +AAF+G M VMR GD ++ R+ A + + T +A GM + AI+G Sbjct: 252 TVAGFGFAAFSGSMAVMRFAGDLVRDRFGAVKTLRACTAIAIIGMLIVGFGNSSATAIIG 311 Query: 307 FAIAGAGVAAVFPFVFSAAGR----HGSTALAAVATLGYSGSLIGPPVFGFLAHGWGL 360 FAI G G++ + P FS AG + S L+ TLGYSG L+ P + GF+A G Sbjct: 312 FAICGIGISNMVPIAFSMAGNMPGVNPSVGLSIATTLGYSGMLVAPSLIGFVARHSGF 369 >DR2502 [GEPR] COG0477 Permeases of the major facilitator superfamily Dra Deinococcus radiodurans Length = 471 Score = 158 bits (399), Expect = 2e-38, Method: Compositional matrix adjust. Identities = 136/374 (36%), Positives = 200/374 (53%), Gaps = 15/374 (4%) Query: 2 TTKHCIPALPQNHQAWRKIAIPFLFLLLGVVFSTWAARIPAIRDQLQLDAATLALVLLCG 61 TT +P P +A ++A+ +FL+ G +F+TWA IP +R L L A + LL Sbjct: 78 TTAAPVPRSPAAERA--RLAVSAVFLINGALFATWAVNIPGVRTALHLTEAQVGAALLAV 135 Query: 62 GIGAVGSFPLAA-WITGHYGARHSSLYAGLALLFSLPLLALAPGLWTLMAVCTLYGAASS 120 G+G++ S PL W+ R ++L A L +L LP + P LW L A L G + Sbjct: 136 GLGSLLSMPLTGGWVARWGSGRVTALLAPLTMLSLLPPFFM-PSLWWLTAALGLLGVLNG 194 Query: 121 CFDVAINALGAQAEREAGRPIMSMLHGWFCVGTFSGALVASAVAGLGVAPLWHFLLAAAL 180 DVA+NA G E+ GRP+MS LH +F +G GAL+ +A+ +G P+ + AL Sbjct: 195 ALDVAMNAQGVTVEKALGRPVMSRLHAYFSLGGVVGALLGTAL--VGRVPMLAHVGGVAL 252 Query: 181 LA--WPLYASCQALPDDRPQYDPQRQLFALPHGHL----VVLGVIAFCGAIVEGSVADWS 234 L+ L A L D + + + P L ++LG + F G + EG+ DW+ Sbjct: 253 LSTLTALVAGRFLLADAPTEPETAQADAPTPRSGLSPAALLLGGLCFLGMLSEGAHYDWA 312 Query: 235 GIYMKDHIGASDGATPLAYAAFAGMMLVMRMVGDGLKARYDARRVVSIGTLVATGGMALA 294 +Y +D +G G + YAAF M + R GD +AR+ +V G L++ G+ LA Sbjct: 313 ALYCRDVLGLPGGQAGVGYAAFVTTMTLGRWFGDRARARFGDVAMVRAGALLSALGLGLA 372 Query: 295 VTAQGMTPAILGFAIAGAGVAAVFPFVFSAAGR--HGSTALAAVATLGYSGSLIGPPVFG 352 + + PA LGFA++G G++ V P ++ AAG HG +A VAT+GY G L+GPP+ G Sbjct: 373 LLVREPWPATLGFALSGLGLSNVVPVMYGAAGHALHGR-GIAQVATIGYGGFLLGPPLIG 431 Query: 353 FLAHGWGLQAALAL 366 FLA GL AAL L Sbjct: 432 FLAQHSGLPAALGL 445 >ybjJ [GEPR] COG0477 Permeases of the major facilitator superfamily Eco Escherichia coli K12 Length = 402 Score = 154 bits (390), Expect = 2e-37, Method: Compositional matrix adjust. Identities = 124/376 (32%), Positives = 184/376 (48%), Gaps = 18/376 (4%) Query: 12 QNHQAWRKIAIPFLFLLLGVVFSTWAARIPAIRDQLQLDAATLALVLLCGGIGAVGSFPL 71 +N R A+ F L G++ ++WA R PAIRD L + A + VL IG++ Sbjct: 7 RNALKRRTWALFMFFFLPGLLMASWATRTPAIRDILSVSIAEMGGVLFGLSIGSMSGILC 66 Query: 72 AAWITGHYGARHSSLYAGLALLFSLPLLALAPGLWT----LMAV-CTLYGAASSCFDVAI 126 +AW+ +G R+ L L + +L+LA LW L AV ++GA+ +VAI Sbjct: 67 SAWLVKRFGTRNVILVTMSCALIGMMILSLA--LWLTSPLLFAVGLGVFGASFGSAEVAI 124 Query: 127 NALGAQAEREAGRPIMSMLHGWFCVGTFSGALVASAVAGLGVAPLWHFLLAAALLAWPLY 186 N GA ERE + ++ M+HG++ +GT +GA V A+ GV H LLAA + P+Y Sbjct: 125 NVEGAAVEREMNKTVLPMMHGFYSLGTLAGAGVGMALTAFGVPATVHILLAALVGIAPIY 184 Query: 187 ASCQALPD-------DRPQYDPQRQLFALPHGHLVVLGVIAFCGAIVEGSVADWSGIYMK 239 + QA+PD D Q+ + F L+++GV+ A EGS DW + M Sbjct: 185 IAIQAIPDGTGKNAADGTQHGEKGVPF-YRDIQLLLIGVVVLAMAFAEGSANDWLPLLMV 243 Query: 240 DHIGASDGATPLAYAAFAGMMLVMRMVGDGLKARYDARRVVSIGTLVATGGMALAVTAQG 299 D G S + L YA F M V R G RY VV L+ G+ L + Sbjct: 244 DGHGFSPTSGSLIYAGFTLGMTVGRFTGGWFIDRYSRVAVVRASALMGALGIGLIIFVDS 303 Query: 300 MTPAILGFAIAGAGVAAVFPFVFSAAGRHG---STALAAVATLGYSGSLIGPPVFGFLAH 356 A + + G G + FP SAA G T ++ VAT GY L+GPP+ G+L Sbjct: 304 AWVAGVSVVLWGLGASLGFPLTISAASDTGPDAPTRVSVVATTGYLAFLVGPPLLGYLGE 363 Query: 357 GWGLQAALALLGALCL 372 +GL++A+ ++ AL + Sbjct: 364 HYGLRSAMLVVLALVI 379 >ECs0925 [GEPR] COG0477 Permeases of the major facilitator superfamily Ecs Escherichia coli O157:H7 Length = 402 Score = 154 bits (390), Expect = 3e-37, Method: Compositional matrix adjust. Identities = 124/376 (32%), Positives = 184/376 (48%), Gaps = 18/376 (4%) Query: 12 QNHQAWRKIAIPFLFLLLGVVFSTWAARIPAIRDQLQLDAATLALVLLCGGIGAVGSFPL 71 +N R A+ F L G++ ++WA R PAIRD L + A + VL IG++ Sbjct: 7 RNALKRRTWALFMFFFLPGLLMASWATRTPAIRDILSVSIAEMGGVLFGLSIGSMSGILC 66 Query: 72 AAWITGHYGARHSSLYAGLALLFSLPLLALAPGLWT----LMAV-CTLYGAASSCFDVAI 126 +AW+ +G R+ L L + +L+LA LW L AV ++GA+ +VAI Sbjct: 67 SAWLVKRFGTRNVILVTMSCALVGMMILSLA--LWLTSPLLFAVGLGVFGASFGSAEVAI 124 Query: 127 NALGAQAEREAGRPIMSMLHGWFCVGTFSGALVASAVAGLGVAPLWHFLLAAALLAWPLY 186 N GA ERE + ++ M+HG++ +GT +GA V A+ GV H LLAA + P+Y Sbjct: 125 NVEGAAVEREMNKTVLPMMHGFYSLGTLAGAGVGMALTAFGVPATVHILLAALVGIAPIY 184 Query: 187 ASCQALPD-------DRPQYDPQRQLFALPHGHLVVLGVIAFCGAIVEGSVADWSGIYMK 239 + QA+PD D Q+ + F L+++GV+ A EGS DW + M Sbjct: 185 IAIQAIPDGTGKNAADGTQHGEKGVPF-YRDIQLLLIGVVVLAMAFAEGSANDWLPLLMV 243 Query: 240 DHIGASDGATPLAYAAFAGMMLVMRMVGDGLKARYDARRVVSIGTLVATGGMALAVTAQG 299 D G S + L YA F M V R G RY VV L+ G+ L + Sbjct: 244 DGHGFSPTSGSLIYAGFTLGMTVGRFTGGWFIDRYSRVAVVRASALMGALGIGLIIFVDS 303 Query: 300 MTPAILGFAIAGAGVAAVFPFVFSAAGRHG---STALAAVATLGYSGSLIGPPVFGFLAH 356 A + + G G + FP SAA G T ++ VAT GY L+GPP+ G+L Sbjct: 304 AWVAGVSVVLWGLGASLGFPLTISAASDTGPDAPTRVSVVATTGYLAFLVGPPLLGYLGE 363 Query: 357 GWGLQAALALLGALCL 372 +GL++A+ ++ AL + Sbjct: 364 HYGLRSAMLVVLALVI 379