BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0042.0217.p (1063 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSp1597 [V] COG0841 Cation/multidrug efflux pump Rso Ralstonia s... 1502 0.0 SMa0875 [V] COG0841 Cation/multidrug efflux pump Sme Sinorhizobi... 402 e-111 aq_786 [V] COG0841 Cation/multidrug efflux pump Aae Aquifex aeol... 373 e-102 AGl494 [V] COG0841 Cation/multidrug efflux pump Atu Agrobacteriu... 354 7e-97 BH3816 [V] COG0841 Cation/multidrug efflux pump Bha Bacillus hal... 345 2e-94 >RSp1597 [V] COG0841 Cation/multidrug efflux pump Rso Ralstonia solanacearum Length = 1064 Score = 1502 bits (3889), Expect = 0.0, Method: Compositional matrix adjust. Identities = 757/1064 (71%), Positives = 879/1064 (82%), Gaps = 5/1064 (0%) Query: 1 MNMVALALRRPYTFIVMALLIVLATPLTLKNMATDIFPEINIPVVSIIWNYNGLSAQEMG 60 M +V LALRRP TFIV+ALLI+LATP L MATDIFPEI+IPV SIIWNYNGL A+EM Sbjct: 1 MWIVQLALRRPLTFIVLALLILLATPFVLMRMATDIFPEIDIPVCSIIWNYNGLPAKEMA 60 Query: 61 QRIAAQNERGLTTVVSDIEHIESQSLAGVSVIKVFFQPKANIQTAIAQVVASVQTQVRQL 120 RI + ER LTT V+DIEHIESQSL GVS+IKVFFQP ANIQTA+AQ+V+ Q Q+RQL Sbjct: 61 DRIVSVTERSLTTTVNDIEHIESQSLGGVSIIKVFFQPTANIQTALAQIVSVSQAQLRQL 120 Query: 121 PPGITPPLVIKYSASSIPVMQLALSSPTLPEQTVFDAAVQTLRPQLVTIPGVAVPYPYGG 180 PPGITPPLVIKYSASSIP++QL LSS TL EQ + DAA+ LRP+L+T+PG+AVP+PYGG Sbjct: 121 PPGITPPLVIKYSASSIPILQLGLSSNTLSEQELNDAALNFLRPRLITVPGIAVPFPYGG 180 Query: 181 KSRLISVDLDTQALQARGLAPIDVVNAINTQNLILPSGTAKFGATEYSVKINGSPEAVAG 240 KSR I+VDLDTQ L A+GL P D+VNA++ QNLILP+GT K A+EY+V +NG+P +A Sbjct: 181 KSRQITVDLDTQKLLAQGLTPTDIVNAVSAQNLILPAGTQKIDASEYAVALNGTPGTIAQ 240 Query: 241 LNELPVRTTNGATIYLKDVANVRDGFSPQTNVVRQDGARGVLLSILKNGGASTLDIVDNL 300 LN +PVRT NGAT+ L DVANVRDGFSPQTNVVRQDG RGVLLSILKNGGASTLDIV N+ Sbjct: 241 LNAMPVRTRNGATLVLGDVANVRDGFSPQTNVVRQDGQRGVLLSILKNGGASTLDIVSNI 300 Query: 301 RKLLPTAAQTLPEDIKITPLFDQSVFVKAAVTGVISEALIAAGLTAAMVLLFLGNWRSTL 360 KLLP AA LP+DIKITPLFDQS+FVKAA+ GVI EALIAA LTAAM+LLFLGNWRST Sbjct: 301 YKLLPVAATALPQDIKITPLFDQSLFVKAAIEGVIREALIAACLTAAMILLFLGNWRSTA 360 Query: 361 IIGLTIPLSIMAAILILAALGETLNLMTLGGLALSVGILVDQAIVTIENIERHLHLGKPL 420 II ++IPLSI+++I++L LGET+NLMTLGGLAL+VGILVD A VTIENIERHLH GK Sbjct: 361 IIAVSIPLSILSSIIVLHLLGETINLMTLGGLALAVGILVDDATVTIENIERHLHEGKAP 420 Query: 421 HDAIIVGAGEIGVPAFVATLCICIVFVPMFFLSGVARFLFVPLAEAVVFAMAASYLLSRT 480 AI+ GA EI VPAFV+TLCICIVFVPMFFL+GVAR+LFVP+AEAV+FAM ASY+LSRT Sbjct: 421 ITAILDGAAEIAVPAFVSTLCICIVFVPMFFLTGVARYLFVPMAEAVIFAMLASYVLSRT 480 Query: 481 LVPTLVMLLMGSHGQVDSAKQSLLQRLYRAFDNRFERVRHGYTLVLSSLLAHRRRFALAF 540 LVPTLVM+LM H + D+ K ++ +Y+AF+ RFE +R Y +L LL HRR FAL+F Sbjct: 481 LVPTLVMMLMTGHTE-DAKKPGPMRYIYQAFNARFEHMRGNYAAILGGLLEHRRVFALSF 539 Query: 541 LGFCLLSCLLYPFLGRDFFPNVDGGQIRLHMRMPTGTRIEETARAADEVERVIRTLIPAS 600 LGFC+ SC LY LGRDFFP+VD GQIRLHMR P+G RIEETAR ADEVE IRT+IP + Sbjct: 540 LGFCVASCALYLALGRDFFPDVDAGQIRLHMRAPSGLRIEETARLADEVEAAIRTIIPRN 599 Query: 601 ELETILDNLGVPNSGINLSYSNAGTIGTLDGEILMALKEGHR-PTEALVSLLRAELPRRF 659 EL T+LDNLGVPNSGINLSYSNAGTIGTLDGEIL+AL+EG R P+ V LR ELP+RF Sbjct: 600 ELATLLDNLGVPNSGINLSYSNAGTIGTLDGEILIALREGERKPSAEYVRRLREELPKRF 659 Query: 660 PGIEFFFQPADIVTQILNFGLPAAIDVQFTGPNMEANARLAAELTKQIRQIPGAVDAHVH 719 PG+EF FQPADIV+QILNFGLP+AIDVQF+G ++ AN +LA L +IR+IPGAVD HVH Sbjct: 660 PGVEFAFQPADIVSQILNFGLPSAIDVQFSGADVAANQQLAGILANRIRRIPGAVDTHVH 719 Query: 720 QRLDGPSLDLRMDRTRLQQFGLSASNVGQNLLIALAGSSQTQPAFWLNPNNGVVYNIAVQ 779 QR D P+L + MDRTR+QQ GL +V QNLL++L+ S QT P FWLNP NGVVY +AVQ Sbjct: 720 QRFDQPTLAVNMDRTRIQQVGLQGRDVAQNLLVSLSSSFQTSPTFWLNPVNGVVYQVAVQ 779 Query: 780 SPQYQVDSLDALLNIPVSPGANASTTP--PQLLGNLVDVHAGRQMAVASRYNIAPAIDVY 837 SPQY+VDSLDALL PV+ +T P PQLLGNLV V Q V S Y+I P +DVY Sbjct: 780 SPQYRVDSLDALLRTPVAGAGGGATQPGGPQLLGNLVQVGPAVQPQVVSHYDITPVVDVY 839 Query: 838 VSVQGTDLASVAGKVSALVEQIKPKLARGSQVVIRGQVETMQSSFTGLGVGLAMAIVLVY 897 +VQG DL +VA +V V++I+PKL RG+Q+ +RGQV TM+SSF GLGVGL MAIVLVY Sbjct: 840 AAVQGRDLGAVAKEVQKAVDEIRPKLPRGAQITVRGQVRTMESSFVGLGVGLVMAIVLVY 899 Query: 898 LLVVVNFQSWIDAAIIIAALPAALAGIAWMLFITGTTLSVPALTGAIMTMGVATANSILI 957 LL+VVNFQSWID II+ ALPAALAGIAWMLF+TGTTLSVP+LTGAIMTMGVATANSIL+ Sbjct: 900 LLIVVNFQSWIDPLIIVTALPAALAGIAWMLFVTGTTLSVPSLTGAIMTMGVATANSILL 959 Query: 958 VAFARQRREEGATPLAAALEAGSTRIRPVLMTALAMIIGMIPMALGLGEGAEQNAPLGRA 1017 ++FAR+R EG P+ AALEAG+TR+RPVLMTALAMIIGM+PMALGLGEGAEQNAPLGRA Sbjct: 960 ISFARERLHEGIAPMQAALEAGATRLRPVLMTALAMIIGMVPMALGLGEGAEQNAPLGRA 1019 Query: 1018 VIGGLMLATVSTLFFVPVVFAGVHQRLARRADQR-RDLAGGPAH 1060 VIGGL+ ATVSTLFFVPVVFA VH RL RRA +R D G H Sbjct: 1020 VIGGLLFATVSTLFFVPVVFASVHGRLQRRAGRRGTDPRGSERH 1063 >SMa0875 [V] COG0841 Cation/multidrug efflux pump Sme Sinorhizobium meliloti Length = 1065 Score = 402 bits (1032), Expect = e-111, Method: Compositional matrix adjust. Identities = 313/1061 (29%), Positives = 516/1061 (48%), Gaps = 52/1061 (4%) Query: 1 MNMVALALRRPYTFIVMALLIVLATPLTLKNMATDIFPEINIPVVSIIWNYNGLSAQEMG 60 M + +++ P +M ++I++ + + D +PE ++PVV + Y G S + + Sbjct: 1 MFLTRISINHPVFATMMMVMILVLGLFSYGRLGVDHYPETDLPVVVVATTYTGASPESVE 60 Query: 61 QRIAAQNERGLTTVVSDIEHIESQSLAGVSVIKVFFQPKANIQTAIAQVVASVQTQVRQL 120 I+ E L T+ I+ I S+S G S++ V F+ + Q A +V V + Sbjct: 61 SEISRPIEAALNTI-GGIDTITSESYEGRSIVVVQFEVDVDSQDAAQEVRDRVARLETKF 119 Query: 121 PPGITPPLVIKYSASSIPVMQLALSSP--TLPEQTVFDAAVQTLRPQLVTIPGVAVPYPY 178 P G+ P V +Y ++ +A+SS TLPE T A + + +L I GV Sbjct: 120 PDGVATPQVTRYKPEGQAILSVAVSSTSRTLPEITTL--ATRVINNRLSVISGVGQVSLI 177 Query: 179 GGKSRLISVDLDTQALQARGLAPIDVVNAINTQNLILPSGTAKFGATEYSVKINGSPEAV 238 G R + V +D L A GLA V+ AI +N +GT G + V + G Sbjct: 178 GSSERQVLVVVDPDRLGAYGLAVSTVIEAIRGENQDRAAGTLISGINQRIVTVEGRIANT 237 Query: 239 AGLNELPVRTTNGATIYLKDVANVRDGFSPQTNVVRQDGARGVLLSILKNGGASTLDIVD 298 +G N + V NG +YL +VA + D + T++ G + L I+K GA+T+++ Sbjct: 238 SGFNRIIVAQRNGYPVYLSEVATILDTGAEVTSLANYQGQTTLGLHIVKVQGANTVEVAS 297 Query: 299 NLRKLLPTAAQTLPED-IKITPLFDQSVFVKAAVTGVISEALIAAG-LTAAMVLLFLGNW 356 +R+ + L +D +++T D S + + V+ V L+ G L+ +V +FL +W Sbjct: 298 AVRREVSALNAELTKDNVQLTITRDNSRPIASQVSQV-QRTLVEGGVLSVLIVFIFLNSW 356 Query: 357 RSTLIIGLTIPLSIMAAILILAALGETLNLMTLGGLALSVGILVDQAIVTIENIERHLHL 416 RST+I GLT+P+S++ + ALG TLN+MTL L+LS+GIL+D AIV ENI RHL + Sbjct: 357 RSTVITGLTLPISVIGTFAAIYALGFTLNIMTLMALSLSIGILIDDAIVVRENITRHLQM 416 Query: 417 GKPLHDAIIVGAGEIGVPAFVATLCICIVFVPMFFLSGVARFLFVPLAEAVVFAMAASYL 476 GK A + G EIG+ TLCI VF+P+ F+ G+ F+ V A+ S Sbjct: 417 GKDPVRAALDGTNEIGLAVLSTTLCIVAVFLPVAFMGGLIGRFFLQFGVTVAVAVVISLF 476 Query: 477 LSRTLVPTLVMLLMGSHGQVDSAKQSLLQRLYRAFDNRFERVRHGYTLVLSSLLAHRRRF 536 +S TL P L + Q +AK+ +L FD FE + Y V+ +R+ Sbjct: 477 VSFTLDPMLSSVWCDPQSQ-KTAKRGFFGQLIERFDQWFEGLASRYRSVIYFTFDYRKTT 535 Query: 537 ALAFLGFCLLSCLLYPFLGRDFFPNVDGGQIRLHMRMPTGTRIEETARAADEVERVIRTL 596 LG ++S LL P +G +F P D G++ + + G ++ A ++ER +R Sbjct: 536 IAIVLGMFVVSLLLVPRIGTEFLPPPDQGEVSISLEANEGASLDYMAAKVGQIERALR-- 593 Query: 597 IPASELETILDNLGVPNSGINLSYSNAGTIGTLDGEILMALKEGHRPTEALVSL-----L 651 E + NSG ++ A L+A++ H L + + Sbjct: 594 ----EFNYVSSTYSTINSGEMRGFNKA----------LVAVQLVHSSQRRLKTAETLGPI 639 Query: 652 RAELPRRFPGIEFFF-QPADIVTQILNFGLPAAIDVQFTGPNMEANARLAAELTKQIRQI 710 R L R G+E Q +++V I + + G E R++ +T + I Sbjct: 640 RRRLSR-IAGLEISVGQRSEVVGSI------KPLQLSILGDGDEELRRISDHITSVLAAI 692 Query: 711 PGAVDAHVHQRLDGPSLDLRMDRTRLQQFGLSASNVGQNLLIALAGSSQTQPAFWLNPNN 770 PGA + P+L +R+ R G+S + +G L +AG + + W +P+ Sbjct: 693 PGATEIESSIEKLRPTLAVRVRREAASDLGVSIATIGDTLRSLVAGDA---ISVWNSPD- 748 Query: 771 GVVYNIAVQSPQYQVDSLDALLNIPVSPGANASTTPP--QLLGNLVDVHAGRQMAVASRY 828 G +++ V+ P ++ L N+P++ P LL + DV A +R Sbjct: 749 GETHDVVVRLPAAGRENAAQLRNLPIATARMDDNGKPIMVLLDQVADVVESTAPAQITRK 808 Query: 829 NIAPAIDVYVSVQGTDLASVAGKVSALVEQIKPKLARGSQVVIRGQVETMQSSFTGLGVG 888 +++ I + +++G L V + A + K + G ++ G E + S Sbjct: 809 DLSRDIRISSNIEGRTLGDVVADLKAAMT--KMDIPVGFRISFGGDAENLTESTAYALQS 866 Query: 889 LAMAIVLVYLLVVVNFQSWIDAAIIIAALPAALAGIAWMLFITGTTLSVPALTGAIMTMG 948 LAMA++ +Y+++ F S+I II +P +L G+ L TG+TL++ ++ G +M MG Sbjct: 867 LAMAVIFIYIILASQFGSFIQPIAIIMTMPLSLMGVLLGLLFTGSTLNMFSMIGIMMLMG 926 Query: 949 VATANSILIVAFARQRREEGATPLAAALEAGSTRIRPVLMTALAMIIGMIPMALGLGEGA 1008 + T N+IL+V ++ EG + + +AG+ R+RP++MT LAMI GM+P ALGLGEG Sbjct: 927 LVTKNAILLVDYSNLGVREGKSLRQSLADAGAVRLRPIVMTTLAMIFGMLPTALGLGEGG 986 Query: 1009 EQNAPLGRAVIGGLMLATVSTLFFVPVV------FAGVHQR 1043 Q AP+ A+IGGL+ +T+ +L FVPVV FAG +R Sbjct: 987 AQRAPMAHAIIGGLISSTLLSLVFVPVVLTYLDAFAGRVRR 1027 >aq_786 [V] COG0841 Cation/multidrug efflux pump Aae Aquifex aeolicus Length = 1000 Score = 373 bits (958), Expect = e-102, Method: Compositional matrix adjust. Identities = 289/1044 (27%), Positives = 495/1044 (47%), Gaps = 61/1044 (5%) Query: 3 MVALALRRPYTFIVMALLIVLATPLTLKNMATDIFPEINIPVVSIIWNYNGLSAQEMGQR 62 M + RP T ++ L V +LK + D P++ PVV I +Y G + Sbjct: 1 MQKFFIERPVTAFMLMLSFVFLGLYSLKLVPIDRLPDVEFPVVRISADYPGADPYVVDTN 60 Query: 63 IAAQNERGLTTVVSDIEHIESQSLAGVSVIKVFFQPKANIQTAIAQVVASVQTQVRQLPP 122 + E ++TV S IE I S+S G + + V F +I A +V ++Q +R+ P Sbjct: 61 VTRIIEEAVSTV-SGIESIISRSYPGFASVVVTFTLDKDIDVATQEVSNAIQRAMRRFPK 119 Query: 123 GITPPLVIKYSASSIPVMQLALSSPTLPEQTVFDAAVQTLRPQLVTIPGVAVPYPYGGKS 182 G+ PP V+K S P+M L L S T Q + A + ++ +L + GV G + Sbjct: 120 GVEPPTVVKVDTSVAPIMVLLLYSDTADYQRLTYYADKVIKRELEKLYGVGSVSLGGFRD 179 Query: 183 RLISVDLDTQALQARGLAPIDVVNAINTQNLILPSGTAKFGATEYSVKINGSPEAVAGLN 242 ++ V L L L P+DV+ I+ + +P+G EY +++ G + L+ Sbjct: 180 NVLWVRLKVSELYGYELTPLDVLREIDKNHQDIPAGNVYGKRREYILRLYGKFKTPEELS 239 Query: 243 ELPVRTTNGATIYLKDVANVRDGFSPQTNVVRQDGARGVLLSILKNGGASTLDIVDNLRK 302 L ++ + L DVA V G + ++ R +G R V L + K +T+ ++D ++ Sbjct: 240 NLYIK----ENLRLGDVARVYFGEDEERSLARFNGNRAVALLVFKQAKVNTVRVIDEIKS 295 Query: 303 LLPTAAQTLPEDIKITPLFDQSVFVKAAVTGVISEALIAAGLTAAMVLLFLGNWRSTLII 362 + + LP DIK+ FD SV+VK ++ E +I LTA V LFLGN R TL+ Sbjct: 296 RMEFFRELLPPDIKLDYTFDASVYVKESIRAAFEEIIIGVFLTAFTVYLFLGNLRLTLVP 355 Query: 363 GLTIPLSIMAAILILAALGETLNLMTLGGLALSVGILVDQAIVTIENIERHLHLGKPLHD 422 IP++I+ I L LG +LN +TL LA++VGI++D AIV +E+I R G P + Sbjct: 356 VFAIPVTILGTIFFLYQLGYSLNTITLLALAVAVGIVIDDAIVVMESIHRRREEGLPPFE 415 Query: 423 AIIVGAGEIGVPAFVATLCICIVFVPMFFLSGVARFLFVPLAEAVVFAMAASYLLSRTLV 482 A + G + +T + +VF+P+ FL GV A ++ A+ SYL++ T Sbjct: 416 AGVKGTRVVMFALLASTSVLIVVFLPVVFLKGVLGTFLKNFALTLIIAIGLSYLVAITFT 475 Query: 483 PTLVMLLMGSHGQVDSAKQSLLQRLYRAFDNRFERVRHGYTLVLSSLLAHRRRFALAFLG 542 P+ + L+ +++ +LY+ F+ F++ L L H+ L Sbjct: 476 PSATVRLITQR-----PRENFFMKLYKRFEGSFDK-------ALRFSLDHKFIVLLLSFF 523 Query: 543 FCLLSCLLYPFLGRDFFPNVDGGQIRLHMRMPTGTRIEETARAADEVERVIRTLIPASEL 602 F LS L+P + ++F P+VD G+ + MRMP GT E A EVER+ Sbjct: 524 FVGLSVYLFPKVKKEFVPHVDEGRFMVRMRMPVGTSFERVKEKAKEVERI---------- 573 Query: 603 ETILDNLGVPNSGINLSYSNAGTIGTLDGEILMALKE-GHRPTEALV-SLLRAELPRRFP 660 +L N + G+ + G G + LKE RP + +V S +R EL Sbjct: 574 --LLKNPHIAKVGMVVGEGVGGAGVH-SGLFFVYLKERSQRPHQMVVMSEVRRELS-ELK 629 Query: 661 GIEFFFQPADIVTQILNFGLPAA----IDVQFT--GPNMEANARLAAELTKQIRQIPGAV 714 ++ +P G+ A+ D+Q+ G +E ++A + + + G Sbjct: 630 NVKVSVEPPH--------GIGASAGRTTDLQYIVRGERIEVLKKIAKSMEEHFSNVEGFR 681 Query: 715 DAHVHQRLDGPSLDLRMDRTRLQQFGLSASNVGQNLLIALAGSSQTQPAFWLNPNNGVVY 774 D L P + + + R +L G+S ++G L ++L + L + Y Sbjct: 682 DVDTSLELSAPYVKISVKREKLSHLGVSVEDLG--LTLSLLFGKYRVGTYELGSES---Y 736 Query: 775 NIAVQSPQYQVDSLDALLNIPVSPGANASTTPPQLLGNLVDVHAGRQMAVASRYNIAPAI 834 + +++ + V + L + + N P + L+D +RYN + Sbjct: 737 DFYIKAEEDFVKEIHNLNRVYIR-ARNGELIP---ITELIDFSIEAGPFSLTRYNRQYSF 792 Query: 835 DVYVSVQGTDLASVAGKVSALVEQ-IKPKLARGSQVVIRGQVETMQSSFTGLGVGLAMAI 893 Y +++G DLA+ +LVE +K L G G+V+ + +F+G + LAM++ Sbjct: 793 VFYANLEGIDLAT----ARSLVEDWLKKNLPFGYTYDTAGRVKEFKKAFSGFVLSLAMSL 848 Query: 894 VLVYLLVVVNFQSWIDAAIIIAALPAALAGIAWMLFITGTTLSVPALTGAIMTMGVATAN 953 + VY+++ F+S ++ +P + G+ +++T T+L+V + G I+ +G+ + Sbjct: 849 IGVYMILASLFESLKHPFTVLLMVPLSALGVFGFMYLTDTSLNVSSYFGIILLVGIIVRD 908 Query: 954 SILIVAFARQRREEGATPLAAALEAGSTRIRPVLMTALAMIIGMIPMALGLGEGAEQNAP 1013 ++L + Q R+EG A LEA R+RP+LMT + ++ ++P+ALGL G+EQ P Sbjct: 909 AVLFIERIIQLRKEGYAVREAILEARRERLRPILMTTITVVSALLPVALGLTAGSEQRKP 968 Query: 1014 LGRAVIGGLMLATVSTLFFVPVVF 1037 L AVIGG+ +LF +PV++ Sbjct: 969 LAIAVIGGIASGLPLSLFLLPVLY 992 >AGl494 [V] COG0841 Cation/multidrug efflux pump Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 1048 Score = 354 bits (908), Expect = 7e-97, Method: Compositional matrix adjust. Identities = 301/1047 (28%), Positives = 515/1047 (49%), Gaps = 48/1047 (4%) Query: 13 TFIVMALLIVLATPLTLKNMATDIFPEINIPVVSIIWNYNGLSAQEMGQRIAAQNERGLT 72 T +++ALL++ A +L+ + D +P +++PVV ++ +Y G + + + + E L Sbjct: 15 TMMMVALLVMGA--FSLQRLGLDQYPNVDVPVVVVVTSYPGATPETVEMEVTRPVEDALN 72 Query: 73 TVVSDIEHIESQSLAGVSVIKVFFQPKANIQTAIAQVVASVQTQVRQLPPGITPPLVIKY 132 + ++ + S S G SV+ F+ + A +V + P P++ ++ Sbjct: 73 AI-GGLDEVTSTSYEGRSVVVAKFKLEVQSSAAAQEVRDKIAAIEANFPEDTKKPVISRF 131 Query: 133 SASSIPVMQLALSSPTLPEQTVFDAAVQTLRPQLVTIPGVAVPYPYGGKSRLISVDLDTQ 192 ++ P++ LA+SS +L + A Q + QL T+ G+ GG+ R I V +D Sbjct: 132 DPAAEPILSLAISSTSLDVPALATLAEQKVVRQLTTVAGIGQATLVGGRKRQIDVTIDET 191 Query: 193 ALQARGLAPIDVVNAINTQNLILPSGTAKFGATEYSVKINGSPEAVAGLNELPVRTTNGA 252 ++A G+ +VV A+ N P+G+ +E +++I E L ++ V G Sbjct: 192 RMRALGIGVNEVVTALRAGNSNSPAGSVVDPVSERTIQIQSRIEEPEALLDMVVARRGGV 251 Query: 253 TIYLKDVANVRDGFSPQTNVVRQDGARGVLLSILKNGGASTLDIVDNLRKLLPT-AAQTL 311 I L+DVA + +G + N +G + + I+K A+T+ +V ++RK L A+ Sbjct: 252 AILLRDVATLSEGAADAENRAIYNGQTALAIDIVKVQDANTVQVVSDVRKRLDALNAELS 311 Query: 312 PEDIKITPLFDQSVFVKAAVTGVISEALIAAGLTAAMVLLFLGNWRSTLIIGLTIPLSIM 371 P++I++ + D S+ ++ +VT V + + A L A+V LFL +WRST+I GLT+P++I+ Sbjct: 312 PQNIQLRIVTDSSIPIQESVTQVQTTLIEGAALAVAIVFLFLNSWRSTVITGLTLPIAII 371 Query: 372 AAILILAALGETLNLMTLGGLALSVGILVDQAIVTIENIERHLHLGKPLHDAIIVGAGEI 431 + ++ LG TLN ++L L LS+GILVD AIV ENI RHLH+GK A + G GEI Sbjct: 372 GTLTVVDFLGFTLNTLSLLALTLSIGILVDDAIVVRENITRHLHMGKSHLRAALDGTGEI 431 Query: 432 GVPAFVATLCICIVFVPMFFLSGVARFLFVPLAEAVVFAMAASYLLSRTLVPTLVMLLMG 491 G+ T I VF+P+ F+ G+ F V A+ S ++ TL P L + Sbjct: 432 GLAVIATTATIVAVFLPVAFMDGIVGRFFYQFGVTVSAAVLISLFVAFTLDPMLSSVWYD 491 Query: 492 SHGQVDSAKQSLLQRLYRAFDNRFERVRHGYTLVLSSLLAHRRRFALAFLGFCLLSCLLY 551 Q D AK+ + RL FD+ FE + Y + L HR L G + S + Sbjct: 492 PDAQAD-AKRGPIGRLIARFDHGFEWMAGQYRHAIDWTLRHRLVTLLVTAGIFIGSLFMV 550 Query: 552 PFLGRDFFPNVDGGQIRLHMRMPTGTRIEETARAADEVERVIRTLIPASELETILDNLGV 611 P +G +F P+ D G+ ++++ P G+ ++ T +V++ +R E+E + + Sbjct: 551 PLVGTEFVPDADEGRFQINLTAPVGSSLDYTTAKLQQVKKALREF---PEVEMLYSTI-- 605 Query: 612 PNSGINLSYSNAGTIGTLDGEILMALKEGHRPTEALVSLLRAELPRR----FPGIEFFFQ 667 N+G G G IL+ L + +SL AE R+ PGIE Sbjct: 606 -NTG--------GAAGKHRAAILVGLVPLSAREQTPLSL--AEPVRKRLSAIPGIEI--- 651 Query: 668 PADIVTQILNFGL---PAAIDVQFTGPNMEANARLAAELTKQIRQIPGAVDAHVHQRLDG 724 IL GL + + + G + ++A L + +++IPG V+ + Sbjct: 652 ------NILQNGLGGGESPVQLSILGDDRAVLEKIANGLVEDMKKIPGLVEVTSSTKDVT 705 Query: 725 PSLDLRMDRTRLQQFGLSASNVGQNLLIALAGSSQTQPAFWLNPNNGVVYNIAVQSPQYQ 784 L +R+ G++ +++ L + G ++ W + + G Y+I V+ P + Sbjct: 706 SILSVRLKPAAASDLGIARADLAAALSALIGGEDVSK---WTDAH-GNSYDIVVRLPVER 761 Query: 785 VDSLDALLNIPVSPGANASTTPPQL--LGNLVDVHAGRQMAVASRYNIAPAIDVYVSVQG 842 L + ++ G + P + L + D+ A R++ I V ++ G Sbjct: 762 RSDAARLGELMITTGRTGANGAPLMVRLDQVADIGTVAAPAEIRRFDNRREILVSANITG 821 Query: 843 TDLASVAGKVSALVEQIKPKLARGSQVVIRGQVETMQSSFTGLGVGLAMAIVLVYLLVVV 902 L V + L L G ++ G+ ETMQ + +G L+MAI+ +Y+++ Sbjct: 822 RTLGDVTETLQGLTA--SRDLPAGYRIRFGGEAETMQETVGHMGTALSMAIIFIYIVLAS 879 Query: 903 NFQSWIDAAIIIAALPAALAGIAWMLFITGTTLSVPALTGAIMTMGVATANSILIVAFAR 962 F S++ I+ +LP +L G+ L + G+T+++ +L G IM MG+ T N IL+V FA Sbjct: 880 QFGSFLQPLAIMVSLPLSLIGVLLGLMVAGSTINMFSLIGFIMLMGLVTKNGILLVDFAN 939 Query: 963 QRREEGATPLAAALEAGSTRIRPVLMTALAMIIGMIPMALGLGEGAEQNAPLGRAVIGGL 1022 + R G T A AG R RP++MT LAMI GMIP+ L +G G Q AP+ AV+GGL Sbjct: 940 RERRRGLTLNEALANAGVIRFRPIIMTTLAMIFGMIPLGLAVGGGGAQRAPMAHAVVGGL 999 Query: 1023 MLATVSTLFFVPVVFA---GVHQRLAR 1046 + +T+ TL VPV+ + + +R AR Sbjct: 1000 ISSTLLTLIVVPVILSYIDSITRRFAR 1026 >BH3816 [V] COG0841 Cation/multidrug efflux pump Bha Bacillus halodurans Length = 1093 Score = 345 bits (886), Expect = 2e-94, Method: Compositional matrix adjust. Identities = 297/1071 (27%), Positives = 511/1071 (47%), Gaps = 80/1071 (7%) Query: 3 MVALALRRPYTFIVMALLIVLATPLTLKNMATDIFPEINIPVVSIIWNYNGLSAQEMGQR 62 M ++RRP IV ++ +L ++ N+ + P++N P+ ++ +Y G SA+E+ + Sbjct: 1 MTQFSIRRPVFTIVGMIIFLLVGGISYVNLPLQLTPDLNPPIGAVTASYPGASAEEVSEN 60 Query: 63 IAAQNERGLTTVVSDIEHIESQSLAGVSVIKVFFQPKANIQTAIAQVVASVQTQVRQLPP 122 + E L+T S + I SQS+ G ++I + F NI +++++ LP Sbjct: 61 VTRILEDELSTT-SGLNKITSQSMEGSAIIILEFGWTTNIDDVENDIISTINRA--DLPD 117 Query: 123 GITPPLVIKYSASSIPVMQLALSSPTLPEQTVFD--AAVQTLRPQLVTIPGVAVPYPYGG 180 G + P +K+ S+ P+M+L ++S T + + D A+ L ++ + GVA +G Sbjct: 118 GASNPSFLKFDPSAFPIMELVVTSDT---EAISDISEALDELEREIGRVEGVASVSSHGR 174 Query: 181 KSRLISVDLDTQALQARGLAPIDVVNAINTQNLILPSGTAKFGATEYSVKINGSPEAVAG 240 + V +D +AL+ L DVV+ I ++ LP GT G + + + +AV Sbjct: 175 LMERVEVTIDDEALEEANLTQQDVVDVIEANDISLPGGTISDGDRSLTTRTIRTLDAVET 234 Query: 241 LNEL--PVRTTNGATIYLKDVANVRDGFSPQTNVVRQDGARGVLLSILKNGGASTLD--- 295 + +L + T G + L DVA+V +T + R + V SI+K A+++D Sbjct: 235 IEDLVLTIDTQTGDDVLLSDVADVSISLEDETVITRANNDPAVQFSIMKEDAANSVDVSV 294 Query: 296 -IVDNLRKLLPTAAQTLPEDIKITPLFDQSVFVKAAVTGVISEALIAAGLTAAMV--LLF 352 I + L +LL Q +D+ L+D+ F+ A+ V+ ALIA G T AMV LF Sbjct: 295 AITERLDELLE---QDRFDDVSAFVLYDEGDFILEAINNVLV-ALIA-GATMAMVVLFLF 349 Query: 353 LGNWRSTLIIGLTIPLSIMAAILILAALGETLNLMTLGGLALSVGILVDQAIVTIENIER 412 L N+++ LIIG+ IP S++ L +LN+++LGGLAL +G+LVD +IV IENI R Sbjct: 350 LRNFKTPLIIGIAIPFSVIVTFAFLYFTNVSLNILSLGGLALGIGMLVDNSIVVIENIYR 409 Query: 413 HLHLGKPLHDAIIVGAGEIGVPAFVATLCICIVFVPMFFLSGVARFLFVPLAEAVVFAMA 472 HL +GK A + G E+ +TL VFVP+ FL+G+ LF+ A V ++ Sbjct: 410 HLSMGKEPKQAALEGTREVRGAITASTLTTISVFVPILFLTGLVGELFIQFALTVSLSLF 469 Query: 473 ASYLLSRTLVPTLVMLLMGSHGQVDSAKQSLLQRLYRAFDNRFERVRHGYTLVLSSLLAH 532 AS L++ TLVP LM S RL R F E R +L+ + Sbjct: 470 ASLLVAITLVP-----LMAS-------------RLLRKFQQNEEAKRQQSRFILT--IER 509 Query: 533 RRRFALAFLGFCLLSCLLY--------PFLGRDFFPNVDGGQIRLHMRMPTGTRIEETAR 584 ++AL L++ LL +G DF ++D G + + + GT +E R Sbjct: 510 SIKWALRHRAMVLIATLLLFVGGLYGLSTVGVDFLEDMDEGLMVVEIEHEPGTSLE---R 566 Query: 585 AADEVERVIRTLIPASELETILDNLGVPNSGINLSYSNAGTIGTLDGEILMAL---KEGH 641 + VE + + L SE+E + G + + N+ +G++ L + Sbjct: 567 TRETVEAIEQKLEDYSEIENFVSTSGARGTNVGRRDGNS-----YEGQVQATLVPSSDRD 621 Query: 642 RPTEALVSLLRAELPRRFPGIEFFFQPADIVTQILNFGLPAAIDVQFTGPNMEANARLAA 701 T V ++ ++ R E P L P + + + + Sbjct: 622 LTTLEFVESIKRDVERVDSDAEINVSPLS-----LQGSEPNTLTFYLSDSDPDRLEEATE 676 Query: 702 ELTKQIRQIPGAVDAHVHQRLDGPSLDLRMDRTRLQQFGLSASNVGQNLLIALAGSSQTQ 761 L +++ + + + + P L +D ++ GL + V Q + G + T Sbjct: 677 ALEEELLERNEVTNLELSIDVTTPEYQLLIDEEAARENGLVPAQVAQFVYDVTLGQTVTT 736 Query: 762 PAFWLNPNNGVVYNIAVQSPQYQVDSLDALLNIPVSPGANASTTPPQLLGNLVDVHAGRQ 821 L +N + Y++ V+ +DSL+ + + + N P LG++V + G Sbjct: 737 ----LEIDNDL-YDLFVRYHPDVLDSLETMEELTIR--NNEGVYVP--LGDVVTIEEGEG 787 Query: 822 MAVASRYNIAPAIDVYVSVQGTDLASVAGKVSALVEQI--KPKLARGSQVVIRGQVETMQ 879 A +R A++ V+ D + G +S++V I + ++ G E ++ Sbjct: 788 PATINRIEQRDAVEFTVTY---DSSLSLGDISSIVLDIVDEQNFEDTTEFAFTGDQEALE 844 Query: 880 SSFTGLGVGLAMAIVLVYLLVVVNFQSWIDAAIIIAALPAALAGIAWMLFITGTTLSVPA 939 ++ L +A+V V+L++ F+S+ +++ +LP + G++ L +TGT+ SV A Sbjct: 845 TAMADLTGAFMLAVVFVFLVMAAQFESFRFPFVVMFSLPLVMIGVSLALLVTGTSFSVMA 904 Query: 940 LTGAIMTMGVATANSILIVAFARQRREEGATPLAAALEAGSTRIRPVLMTALAMIIGMIP 999 G I+ G+ N+I+IV + Q + GAT A +EA R RPVLMTAL I+G++P Sbjct: 905 GIGMIILAGIVVNNAIVIVDYMNQLKASGATSYEAIVEAVKQRTRPVLMTALTTILGVLP 964 Query: 1000 MALGLGEGAEQNAPLGRAVIGGLMLATVSTLFFVPVVFAGVHQRLARRADQ 1050 +AL LGEG E P+G VIGGL+ T TLF +PV+++ + + RR ++ Sbjct: 965 LALALGEGTEMQRPIGLTVIGGLISGTFLTLFVIPVIYS-LFDKDTRRLNK 1014