BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0042.0161.p (298 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc2507 [GER] COG0697 Permeases of the drug/metabolite transport... 164 2e-40 VCA0090 [GER] COG0697 Permeases of the drug/metabolite transport... 162 1e-39 AGc3767 [GER] COG0697 Permeases of the drug/metabolite transport... 117 2e-26 BH0396 [GER] COG0697 Permeases of the drug/metabolite transporte... 107 4e-23 SMc01844 [GER] COG0697 Permeases of the drug/metabolite transpor... 88 3e-17 >RSc2507 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Rso Ralstonia solanacearum Length = 310 Score = 164 bits (416), Expect = 2e-40, Method: Compositional matrix adjust. Identities = 118/281 (41%), Positives = 169/281 (60%), Gaps = 2/281 (0%) Query: 1 MSSSNLCKLLLLAAIWGTSFMLMRIAAPVFGPMLTTFGRASLATLALLAFARVRGVPMQW 60 M S+ +LL+LAA+WG SF+ MR+AAP FGP+ R ++A+ LL +RG Sbjct: 1 MRRSDAIELLILAALWGGSFLFMRVAAPPFGPVALIALRVAIASAFLLPVLAMRGGLGAL 60 Query: 61 RSNWLPYLVIGIFNTALPFALFAWSALHIPSAYMATMNSLALVFTAMFGFLLMGERLSLV 120 R +W L +G+ N+A+PF L A++ L + + + + +N+ A +F A+ F +GER+S Sbjct: 61 RPHWPHLLAVGVLNSAVPFCLLAYAELTLTAGFTSVLNAAAPLFAAIVAFAWLGERMSAW 120 Query: 121 RCAAFVLGLVGVAVLVGIGPAPADAMVIAGVLAAMGAAVSYGFAATFTRLRAGGISPIAL 180 R +G VGV VLVG A V AA+GA V YG A ++ + G+ P+A+ Sbjct: 121 RVLGLAIGFVGVIVLVGGSSALDARQGGLAVAAALGATVLYGLAGSYAKRYLTGVPPLAV 180 Query: 181 ATGSQFAAALCLLPLAAPSMPHALQAGTLPALLAVLVLGVVCTGIAYALFFQLIAAEGAT 240 ATGSQ AAA+ L PLA P G++ L V+ LG+ CTGIAY LFF+LIA G T Sbjct: 181 ATGSQIAAAVVLAPLAVWLWPAHTPTGSV--WLHVIGLGIACTGIAYILFFRLIAHVGPT 238 Query: 241 KAITVTFLVPMTASLWAWLLLDEPVTLGTVTGIAIVLVATA 281 +A++VTFLVP+ LW L L E +TL V G A++L+ T+ Sbjct: 239 RAVSVTFLVPVFGVLWGILFLGEQLTLNMVAGCAVILLGTS 279 >VCA0090 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Vch Vibrio cholerae Length = 297 Score = 162 bits (409), Expect = 1e-39, Method: Compositional matrix adjust. Identities = 113/279 (40%), Positives = 164/279 (58%), Gaps = 25/279 (8%) Query: 13 AAIWGTSFMLMRIAAPVFGPMLTTFGRASLATLALLAFARV--RGVPMQWRSNWLPYLVI 70 AAIWG SF+ MRIAA FGP R A L+L A++ R +P+ R +W +L++ Sbjct: 13 AAIWGGSFLFMRIAAHSFGPAYLIEARVGFAALSLFLVAQLLRRSLPI--RQHWPHFLIL 70 Query: 71 GIFNTALPFALFAWSALHIPSAYMATMNSLALVFTAMFGFLLMGERLSLVRCAAFVLGLV 130 G+ NTA+PF LFA++AL + + ++ +NS A ++ A+ GFL G LS A +LG+ Sbjct: 71 GLINTAVPFLLFAYAALTLNVSTLSILNSTAPIWGAVIGFLWHGTPLSRKAVAGLLLGVS 130 Query: 131 GVAVLVG-----IGPAPADAMVIAGVLAAMGAAVSYGFAATFTRLRAGGISPIALATGSQ 185 GVAV+VG IG A MV A + AA SYG A +T+ +A +S A GS Sbjct: 131 GVAVIVGWDMVAIGHHAALPMVCAAL-----AAASYGLATNYTK-QAPQLSAFENAHGSM 184 Query: 186 FAAALCLLPL----AAPSMPHALQAGTLPALLAVLVLGVVCTGIAYALFFQLIAAEGATK 241 +AA L + PL P +L+ G AV++LGV+CTG+AY ++F+L+ A GA Sbjct: 185 WAACLWVAPLMWFVPLRETPSSLEWG------AVILLGVICTGLAYLIYFRLVKAIGAAS 238 Query: 242 AITVTFLVPMTASLWAWLLLDEPVTLGTVTGIAIVLVAT 280 ++VTFL+P+ LW + +LDEP+ L T+ G +VL T Sbjct: 239 TLSVTFLIPVFGILWGYWILDEPIGLNTLFGTLLVLAGT 277 >AGc3767 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 329 Score = 117 bits (294), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 91/282 (32%), Positives = 150/282 (53%), Gaps = 9/282 (3%) Query: 1 MSSSNLCKLLLLAAIWGTSFMLMRIAAPVFGPMLTTFGRASLATLALLAFARVRGV--PM 58 M + L+ L+ +WG SF + +A P+ R SLA +ALL R+ G+ P Sbjct: 27 MDAREWAMLIALSLLWGGSFFFIGVAVKELPPVTIVTLRVSLAAVALLVVCRIMGLRLPR 86 Query: 59 QWRSNWLPYLVIGIFNTALPFALFAWSALHIPSAYMATMNSLALVFTAMFG-FLLMGERL 117 +W + W + +G+ N +PF L W I S + +N+ +FT + FL E++ Sbjct: 87 EW-AVWRAFFGMGLLNNIIPFCLIVWGQTQIASGLASILNATTPLFTVIVAHFLTADEKM 145 Query: 118 SLVRCAAFVLGLVGVAVLVGIGPAP-ADAMVIAGVLAAMGAAVSYGFAATF-TRLRAGGI 175 + + A ++G VGVA + IGPA + + G +A +GAA+SY FA F R +A G+ Sbjct: 146 TGNKLAGVLIGFVGVATM--IGPAAFGGSSGLWGQIAILGAAISYSFAGIFGRRFKAMGV 203 Query: 176 SPIALATGSQFAAALCLLPLAA-PSMPHALQAGTLPALLAVLVLGVVCTGIAYALFFQLI 234 P+ ATG ++ L L+P A P L L A++ + ++ T +AY +FF+++ Sbjct: 204 PPLMTATGQISSSTLMLIPAALLIDKPWTLAMPGLGTWGALIGIALLSTALAYLIFFRIL 263 Query: 235 AAEGATKAITVTFLVPMTASLWAWLLLDEPVTLGTVTGIAIV 276 A+ GAT VTFL+P++A L L+L E + + G+A++ Sbjct: 264 ASAGATNLALVTFLIPVSAILLGSLILGEQLEIKHFAGMAMI 305 >BH0396 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Bha Bacillus halodurans Length = 305 Score = 107 bits (266), Expect = 4e-23, Method: Compositional matrix adjust. Identities = 85/295 (28%), Positives = 137/295 (46%), Gaps = 8/295 (2%) Query: 9 LLLLAAIWGTSFMLMRIAAPVFGPMLTTFGRASLATLALLAFARVRGVPMQWRSNWLPYL 68 LL L+ IWG SF+ + + G T R + LL +R + W + Sbjct: 7 LLSLSLIWGFSFVFIEHLLGIVGVWGTVVVRCFAGAIILLPILLMRRKLFYRPAPWKALM 66 Query: 69 VIGIFNTALPFALFAWSALHIPSAYMATMNSLALVFTAMFGFLLMGERLSLVRCAAFVLG 128 ++GIFN LP+ L A S I S+ A +N+L +FT + GFLL LS + VLG Sbjct: 67 IVGIFNAGLPWGLIALSQTEIYSSTAAVLNALTPLFTGLIGFLLYSNALSRQQWGGIVLG 126 Query: 129 LVGVAVLVGIGPAPADAMVIAGVLAAMGAAVSYGFAATFTRLRAGGISPIALATGSQFAA 188 GV VL G GV + A + YGFA+ + + + + T S Sbjct: 127 FSGVVVLTGFQLQLLAPEHFVGVGTMILATICYGFASQYVKRHLHDTDVVLITTFSLLFG 186 Query: 189 ALCLLPLAAPSMPHALQAGTLP------ALLAVLVLGVVCTGIAYALFFQLIAAEGATKA 242 L+ L + +L +P +L++++ LG + +G+A+ L++ L+ G A Sbjct: 187 G--LVGLIGMWITDSLHVVRVPLTIDWLSLISIIGLGCLGSGMAHLLYYDLMKKGGPEFA 244 Query: 243 ITVTFLVPMTASLWAWLLLDEPVTLGTVTGIAIVLVATATALRAKPAVAARTKAT 297 TVT+L+PMTA +W L LDE +T V G+ ++L+ R + + + + Sbjct: 245 TTVTYLIPMTAIIWGKLFLDELITKNIVIGMLMILMGVYFTSRKRNVCSKANEDS 299 >SMc01844 [GER] COG0697 Permeases of the drug/metabolite transporter (DMT) superfamily Sme Sinorhizobium meliloti Length = 314 Score = 87.8 bits (216), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 77/223 (34%), Positives = 116/223 (52%), Gaps = 12/223 (5%) Query: 63 NWLPYLVIGIFNTALPFALFAWSALHIPSAYMATMNSLALVFTAMFGFL-LMGERLSLVR 121 W +L++G+ N A+P A HI + A +N+ V+T + + E+LS + Sbjct: 75 RWREFLLMGLINNAIPHAFIFLGQTHIGAGLAAILNATTPVWTVLIANVATEDEKLSTAK 134 Query: 122 CAAFVLGLVGVAVLVG-------IGPAPADAMVIAGVLAAMGAAVSYGFAATFTRLRAGG 174 + +LGL G VL+G G A D + A VL + AAVSYGF+AT+ + R Sbjct: 135 FSGCLLGLAGTVVLIGPSALAGLFGTA-GDVPLWALVLPVL-AAVSYGFSATYGK-RFRD 191 Query: 175 ISPIALATGSQFAAALCLLPLAA-PSMPHALQAGTLPALLAVLVLGVVCTGIAYALFFQL 233 ++P A G A+ L +LP+A MP + L +LA+L L +V T AY LFF++ Sbjct: 192 LAPPVTAAGQLTASTLIMLPVAVLVDMPWTMPMPPLTTVLAILGLALVSTAYAYILFFRI 251 Query: 234 IAAEGATKAITVTFLVPMTASLWAWLLLDEPVTLGTVTGIAIV 276 +A GAT VT LVP +A L +L L E + V G+ ++ Sbjct: 252 MAEAGATNTSLVTLLVPPSAILLGYLFLGEMLQATDVGGMLLI 294