BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0042.0128.p (444 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc3275 [C] COG1301 Na+/H+-dicarboxylate symporters Rso Ralstoni... 556 e-158 PA0119 [C] COG1301 Na+/H+-dicarboxylate symporters Pae Pseudomon... 486 e-137 dctA [C] COG1301 Na+/H+-dicarboxylate symporters Eco Escherichia... 438 e-122 ZdctA [C] COG1301 Na+/H+-dicarboxylate symporters EcZ Escherichi... 437 e-122 ECs4408 [C] COG1301 Na+/H+-dicarboxylate symporters Ecs Escheric... 437 e-122 >RSc3275 [C] COG1301 Na+/H+-dicarboxylate symporters Rso Ralstonia solanacearum Length = 446 Score = 556 bits (1434), Expect = e-158, Method: Compositional matrix adjust. Identities = 294/419 (70%), Positives = 346/419 (82%) Query: 1 VSKLFKSLFGQVVLALIGGIIIGLLWPDFGQNLKPLGDGFIKLIKMIIPVIVFCVVVQGI 60 + + + LFGQV++AL GI +G+ PDF Q+LKPLGDGF+KLIKM+I IVF VVV GI Sbjct: 1 MQRFTRPLFGQVLIALALGIALGIWAPDFAQHLKPLGDGFLKLIKMLIAPIVFSVVVVGI 60 Query: 61 CGASDLKKVGSVGVKAIIYFEVVTTIALLLGLVLALVVQPGAGMNIDPSNLDASSLSGYM 120 CGA +LKKVG VG KA+IYFEVVTTIAL LG+ LA PG GMN+DP LDAS++S YM Sbjct: 61 CGAGELKKVGRVGGKAVIYFEVVTTIALALGIALAYAFGPGHGMNVDPKTLDASAMSSYM 120 Query: 121 ANAGKVKETGFAEFIMKLIPATAVSAFTSGDVLQVLLISVTFGCALLLIGEKGAPVVALV 180 A A +V+ +G AEF++KLIP T VS F GD+LQVLL+S+ FGCAL L+GE+ P+V L+ Sbjct: 121 ATAKQVESSGVAEFLLKLIPDTFVSGFMKGDILQVLLVSILFGCALSLLGERTKPLVGLI 180 Query: 181 ASLSDAFFKCMSFFIRLAPLGVLGAIAFTVGKYGIGSLKQLALLVLLFYGAVIFFVLVVL 240 LS F+ M+ IRLAPLGVLGA+AFTVGKYG GSLKQL LVLLFY AV FV+VVL Sbjct: 181 DQLSHVLFRMMAVVIRLAPLGVLGAVAFTVGKYGAGSLKQLGFLVLLFYAAVAVFVVVVL 240 Query: 241 GGILRASGLSIFKLIRYLREELVVVLATTSSDSVLPQIMKKLEHMGIKKSTVGLVIPTGY 300 GGILR +G SIFKLIR+LR EL+VVL T SSD+VLP +M KLE MGIK+S VGLVIPTGY Sbjct: 241 GGILRLAGFSIFKLIRFLRAELLVVLGTASSDAVLPSVMNKLEKMGIKRSVVGLVIPTGY 300 Query: 301 SFNLDAFSIYLTMAALFIAQATNTHLSMGDLAAILAIALVTSKGAHGVPGSAIVILAATL 360 SFNLDAFSIYLT+AA+FIAQATNT L++ DL IL +AL+TSKGAHG+PGSAIVILAATL Sbjct: 301 SFNLDAFSIYLTLAAVFIAQATNTPLALSDLLLILGVALITSKGAHGIPGSAIVILAATL 360 Query: 361 TTIPAIPVVGLVLVLSIDWFIGIARALGNLLGNCVATVVIASWEKDIDKVRARAVLNGE 419 + IPAIP +GLVLVLS+DWFIGIARALGNLLGNCVATVVIA+WEKDID+ RA AVL+G+ Sbjct: 361 SVIPAIPAIGLVLVLSVDWFIGIARALGNLLGNCVATVVIAAWEKDIDRARANAVLDGK 419 >PA0119 [C] COG1301 Na+/H+-dicarboxylate symporters Pae Pseudomonas aeruginosa Length = 449 Score = 486 bits (1250), Expect = e-137, Method: Compositional matrix adjust. Identities = 248/424 (58%), Positives = 314/424 (74%), Gaps = 4/424 (0%) Query: 1 VSKLFKSLFGQVVLALIGGIIIGLLWPDFGQNLKPLGDGFIKLIKMIIPVIVFCVVVQGI 60 + + +S+F QVV+ L+ G+I G+ PD +KPLGDGFIKLIKM+I +IVFCVVV GI Sbjct: 8 IKRCSRSIFLQVVIGLVIGVICGVGIPDLAVQMKPLGDGFIKLIKMLIALIVFCVVVNGI 67 Query: 61 CGASDLKKVGSVGVKAIIYFEVVTTIALLLGLVLALVVQPGAGMNIDPSNLDASSLSGYM 120 GA DLKKVG +G+K++IYFE++TTIAL+LGLV+A + G+G NI + L A ++ Y Sbjct: 68 SGAGDLKKVGRIGLKSVIYFEILTTIALVLGLVVAYSLGLGSGANIHLNELPAGDVALY- 126 Query: 121 ANAGKVKE-TGFAEFIMKLIPATAVSAFTSGDVLQVLLISVTFGCALLLIGEKGAPVVAL 179 G+ +E G F+M LIP + SAF D+LQVLL SV FG AL L+GE+ + V L Sbjct: 127 --TGRTQEIHGPVAFLMGLIPTSVFSAFAENDILQVLLFSVLFGSALNLVGEQASGVARL 184 Query: 180 VASLSDAFFKCMSFFIRLAPLGVLGAIAFTVGKYGIGSLKQLALLVLLFYGAVIFFVLVV 239 + S F+ M +RLAPLGV GA+AFT +YG+ SL L LVL+FY + FV+ V Sbjct: 185 INEFSHIVFRIMGMIVRLAPLGVFGAVAFTTARYGVDSLSHLGALVLVFYATCLVFVMAV 244 Query: 240 LGGILRASGLSIFKLIRYLREELVVVLATTSSDSVLPQIMKKLEHMGIKKSTVGLVIPTG 299 LG +LR SG+ + +RY REEL++V+ T SSD+VLPQ+M+KLEHMGI+ STVGLVIPTG Sbjct: 245 LGSVLRLSGVRMLPFLRYFREELLIVMGTASSDAVLPQVMRKLEHMGIRSSTVGLVIPTG 304 Query: 300 YSFNLDAFSIYLTMAALFIAQATNTHLSMGDLAAILAIALVTSKGAHGVPGSAIVILAAT 359 YSFNLD FSIYLT+A +FIA T T L+M DL IL ++LVTSKGAHG+PGSA+VILAAT Sbjct: 305 YSFNLDGFSIYLTLAVVFIAHVTGTPLAMTDLITILLVSLVTSKGAHGIPGSALVILAAT 364 Query: 360 LTTIPAIPVVGLVLVLSIDWFIGIARALGNLLGNCVATVVIASWEKDIDKVRARAVLNGE 419 LT +PAIPV GLVLVLS+DWF+GI RAL NL+GNCVATV IA WE DID RA+A+L+G Sbjct: 365 LTAVPAIPVAGLVLVLSVDWFMGIGRALTNLIGNCVATVTIARWENDIDMPRAQAILDGR 424 Query: 420 SVAP 423 AP Sbjct: 425 LEAP 428 >dctA [C] COG1301 Na+/H+-dicarboxylate symporters Eco Escherichia coli K12 Length = 428 Score = 438 bits (1127), Expect = e-122, Method: Compositional matrix adjust. Identities = 219/419 (52%), Positives = 305/419 (72%), Gaps = 3/419 (0%) Query: 2 SKLFKSLFGQVVLALIGGIIIGLLWPDFGQNLKPLGDGFIKLIKMIIPVIVFCVVVQGIC 61 + LFKSL+ QV+ A+ GI++G +P+ G+ +KPLGDGF+KLIKMII ++FC VV GI Sbjct: 3 TSLFKSLYFQVLTAIAIGILLGHFYPEIGEQMKPLGDGFVKLIKMIIAPVIFCTVVTGIA 62 Query: 62 GASDLKKVGSVGVKAIIYFEVVTTIALLLGLVLALVVQPGAGMNIDPSNLDASSLSGYMA 121 G +K VG G A++YFE+V+TIAL++GL++ VVQPGAGMN+DP+ LDA +++ Y Sbjct: 63 GMESMKAVGRTGAVALLYFEIVSTIALIIGLIIVNVVQPGAGMNVDPATLDAKAVAVY-- 120 Query: 122 NAGKVKETGFAEFIMKLIPATAVSAFTSGDVLQVLLISVTFGCALLLIGEKGAPVVALVA 181 A + K+ G FIM +IPA+ + AF SG++LQVLL +V FG AL +G KG + ++ Sbjct: 121 -ADQAKDQGIVAFIMDVIPASVIGAFASGNILQVLLFAVLFGFALHRLGSKGQLIFNVIE 179 Query: 182 SLSDAFFKCMSFFIRLAPLGVLGAIAFTVGKYGIGSLKQLALLVLLFYGAVIFFVLVVLG 241 S S F ++ +RLAP+G GA+AFT+GKYG+G+L QL L++ FY I FV++VLG Sbjct: 180 SFSQVIFGIINMIMRLAPIGAFGAMAFTIGKYGVGTLVQLGQLIICFYITCILFVVLVLG 239 Query: 242 GILRASGLSIFKLIRYLREELVVVLATTSSDSVLPQIMKKLEHMGIKKSTVGLVIPTGYS 301 I +A+G SIFK IRY+REEL++VL T+SS+S LP+++ K+E +G +KS VGLVIPTGYS Sbjct: 240 SIAKATGFSIFKFIRYIREELLIVLGTSSSESALPRMLDKMEKLGCRKSVVGLVIPTGYS 299 Query: 302 FNLDAFSIYLTMAALFIAQATNTHLSMGDLAAILAIALVTSKGAHGVPGSAIVILAATLT 361 FNLD SIYLTMAA+FIAQATN+ + + +L + L++SKGA GV GS ++LAATL+ Sbjct: 300 FNLDGTSIYLTMAAVFIAQATNSQMDIVHQITLLIVLLLSSKGAAGVTGSGFIVLAATLS 359 Query: 362 TIPAIPVVGLVLVLSIDWFIGIARALGNLLGNCVATVVIASWEKDIDKVRARAVLNGES 420 + +PV GL L+L ID F+ ARAL NL+GN VAT+V+A W K++D + VLN + Sbjct: 360 AVGHLPVAGLALILGIDRFMSEARALTNLVGNGVATIVVAKWVKELDHKKLDDVLNNRA 418 >ZdctA [C] COG1301 Na+/H+-dicarboxylate symporters EcZ Escherichia coli O157:H7 EDL933 Length = 428 Score = 437 bits (1123), Expect = e-122, Method: Compositional matrix adjust. Identities = 218/419 (52%), Positives = 304/419 (72%), Gaps = 3/419 (0%) Query: 2 SKLFKSLFGQVVLALIGGIIIGLLWPDFGQNLKPLGDGFIKLIKMIIPVIVFCVVVQGIC 61 + LFKSL+ QV+ A+ GI++G +P+ G+ +KPLGDGF+KLIKMII ++FC VV GI Sbjct: 3 TSLFKSLYFQVLTAIAIGILLGHFYPEIGEQMKPLGDGFVKLIKMIIAPVIFCTVVTGIA 62 Query: 62 GASDLKKVGSVGVKAIIYFEVVTTIALLLGLVLALVVQPGAGMNIDPSNLDASSLSGYMA 121 G +K VG G A++YFE+V+TIAL++GL++ VVQPGAGMN+DP+ LDA +++ Y Sbjct: 63 GMESMKAVGRTGAVALLYFEIVSTIALIIGLIIVNVVQPGAGMNVDPATLDAKAVAVY-- 120 Query: 122 NAGKVKETGFAEFIMKLIPATAVSAFTSGDVLQVLLISVTFGCALLLIGEKGAPVVALVA 181 A + K+ G FIM +IPA+ + AF SG++LQVLL +V FG AL +G KG + ++ Sbjct: 121 -ADQAKDQGIVAFIMDVIPASVIGAFASGNILQVLLFAVLFGFALHRLGSKGQLIFNVIE 179 Query: 182 SLSDAFFKCMSFFIRLAPLGVLGAIAFTVGKYGIGSLKQLALLVLLFYGAVIFFVLVVLG 241 S S F ++ +RLAP+G GA+AFT+GKYG+G+L QL L++ FY I FV++VLG Sbjct: 180 SFSQVIFGIINMIMRLAPIGAFGAMAFTIGKYGVGTLVQLGQLIICFYITCILFVVLVLG 239 Query: 242 GILRASGLSIFKLIRYLREELVVVLATTSSDSVLPQIMKKLEHMGIKKSTVGLVIPTGYS 301 I +A+G SIFK IRY+REEL++VL T+SS+S LP+++ K+E +G +KS VGLVIPTGYS Sbjct: 240 SIAKATGFSIFKFIRYIREELLIVLGTSSSESALPRMLDKMEKLGCRKSVVGLVIPTGYS 299 Query: 302 FNLDAFSIYLTMAALFIAQATNTHLSMGDLAAILAIALVTSKGAHGVPGSAIVILAATLT 361 FNLD SIYLTMAA+FIAQATN+ + + +L + L++SKGA GV GS ++LAATL+ Sbjct: 300 FNLDGTSIYLTMAAVFIAQATNSQMDIVHQITLLIVLLLSSKGAAGVTGSGFIVLAATLS 359 Query: 362 TIPAIPVVGLVLVLSIDWFIGIARALGNLLGNCVATVVIASWEKDIDKVRARAVLNGES 420 + +PV GL L+L ID F+ ARAL NL+GN VAT+V+A W K++D + LN + Sbjct: 360 AVGHLPVAGLALILGIDRFMSEARALTNLVGNGVATIVVAKWVKELDHKKLDDALNNRA 418 >ECs4408 [C] COG1301 Na+/H+-dicarboxylate symporters Ecs Escherichia coli O157:H7 Length = 428 Score = 437 bits (1123), Expect = e-122, Method: Compositional matrix adjust. Identities = 218/419 (52%), Positives = 304/419 (72%), Gaps = 3/419 (0%) Query: 2 SKLFKSLFGQVVLALIGGIIIGLLWPDFGQNLKPLGDGFIKLIKMIIPVIVFCVVVQGIC 61 + LFKSL+ QV+ A+ GI++G +P+ G+ +KPLGDGF+KLIKMII ++FC VV GI Sbjct: 3 TSLFKSLYFQVLTAIAIGILLGHFYPEIGEQMKPLGDGFVKLIKMIIAPVIFCTVVTGIA 62 Query: 62 GASDLKKVGSVGVKAIIYFEVVTTIALLLGLVLALVVQPGAGMNIDPSNLDASSLSGYMA 121 G +K VG G A++YFE+V+TIAL++GL++ VVQPGAGMN+DP+ LDA +++ Y Sbjct: 63 GMESMKAVGRTGAVALLYFEIVSTIALIIGLIIVNVVQPGAGMNVDPATLDAKAVAVY-- 120 Query: 122 NAGKVKETGFAEFIMKLIPATAVSAFTSGDVLQVLLISVTFGCALLLIGEKGAPVVALVA 181 A + K+ G FIM +IPA+ + AF SG++LQVLL +V FG AL +G KG + ++ Sbjct: 121 -ADQAKDQGIVAFIMDVIPASVIGAFASGNILQVLLFAVLFGFALHRLGSKGQLIFNVIE 179 Query: 182 SLSDAFFKCMSFFIRLAPLGVLGAIAFTVGKYGIGSLKQLALLVLLFYGAVIFFVLVVLG 241 S S F ++ +RLAP+G GA+AFT+GKYG+G+L QL L++ FY I FV++VLG Sbjct: 180 SFSQVIFGIINMIMRLAPIGAFGAMAFTIGKYGVGTLVQLGQLIICFYITCILFVVLVLG 239 Query: 242 GILRASGLSIFKLIRYLREELVVVLATTSSDSVLPQIMKKLEHMGIKKSTVGLVIPTGYS 301 I +A+G SIFK IRY+REEL++VL T+SS+S LP+++ K+E +G +KS VGLVIPTGYS Sbjct: 240 SIAKATGFSIFKFIRYIREELLIVLGTSSSESALPRMLDKMEKLGCRKSVVGLVIPTGYS 299 Query: 302 FNLDAFSIYLTMAALFIAQATNTHLSMGDLAAILAIALVTSKGAHGVPGSAIVILAATLT 361 FNLD SIYLTMAA+FIAQATN+ + + +L + L++SKGA GV GS ++LAATL+ Sbjct: 300 FNLDGTSIYLTMAAVFIAQATNSQMDIVHQITLLIVLLLSSKGAAGVTGSGFIVLAATLS 359 Query: 362 TIPAIPVVGLVLVLSIDWFIGIARALGNLLGNCVATVVIASWEKDIDKVRARAVLNGES 420 + +PV GL L+L ID F+ ARAL NL+GN VAT+V+A W K++D + LN + Sbjct: 360 AVGHLPVAGLALILGIDRFMSEARALTNLVGNGVATIVVAKWVKELDHKKLDDALNNRA 418