BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0042.0125.p (338 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value FN1406 [E] COG2986 Histidine ammonia-lyase Fnu Fusobacterium nuc... 231 1e-60 FN0791 [E] COG2986 Histidine ammonia-lyase Fnu Fusobacterium nuc... 221 2e-57 CC0959 Non COG 211 2e-54 TVN1353 [E] COG2986 Histidine ammonia-lyase Tvo Thermoplasma vol... 211 2e-54 Ta0242 [E] COG2986 Histidine ammonia-lyase Tac Thermoplasma acid... 210 4e-54 >FN1406 [E] COG2986 Histidine ammonia-lyase Fnu Fusobacterium nucleatum Length = 511 Score = 231 bits (590), Expect = 1e-60, Method: Compositional matrix adjust. Identities = 133/310 (42%), Positives = 185/310 (59%), Gaps = 31/310 (10%) Query: 2 AILAAHDARHLLTDACLSLGLTLEAMRAEMSAFDPRIQQARPHAGQIKTAEVIRTLLQGS 61 A+LA +DA LL A + L+++A+ + AFD RI RPH GQI +AE +R LL+GS Sbjct: 206 AVLAVYDAEKLLKQADIVASLSIDALGGIIDAFDERIHLIRPHKGQIYSAENLRKLLKGS 265 Query: 62 TRTTHXRGDPHAPAGFQLPEELRRTDIAYTARIQDVYSLRCAPQVYGPVFDALDYIDTII 121 RTT +G+ R+QD YSLRC PQV+G A DY+ + Sbjct: 266 KRTTR-QGEK---------------------RMQDAYSLRCTPQVHGASRLAFDYVKQTV 303 Query: 122 EKETNSATDNPLIFHKEEGEGFEIISGGNFHGQYLAQAMDLLAMAITDLGSICERRIARL 181 E E NS TDNPLIF E G ISGGNFHGQ +A AMD L + ++++ +I ERRI +L Sbjct: 304 ETEINSVTDNPLIFPGENGA---CISGGNFHGQPIAIAMDTLGILMSEIANISERRIEKL 360 Query: 182 IDPTLSWGLPRNLMSGVRGVNTGYPVVQCSMSSLVMENRTLCMPGSVDSIPSKGNSEDHI 241 ++P LS GLP L+ G+N G+ + Q ++LV EN+ L P SVDSIP+ N EDH+ Sbjct: 361 VNPALSHGLPAFLVKN-GGINDGFMIPQYVAAALVSENKVLAHPASVDSIPTSANQEDHV 419 Query: 242 SNSTWCARKAMTVVQNTQYIVGVEMLLAAQALTMTEALLKDFVLGQGTQAAYAEIRRQIP 301 S T ARKA T+V + Q++V +E+L AAQA ++ K+ LG GT+ AY +R ++ Sbjct: 420 SMGTIGARKARTIVDHAQHVVSIELLCAAQAADFWDS--KN--LGVGTKEAYRTLREKVD 475 Query: 302 ACLDGDRWFH 311 ++ D F+ Sbjct: 476 -FMENDVIFY 484 >FN0791 [E] COG2986 Histidine ammonia-lyase Fnu Fusobacterium nucleatum Length = 516 Score = 221 bits (563), Expect = 2e-57, Method: Compositional matrix adjust. Identities = 120/331 (36%), Positives = 190/331 (57%), Gaps = 31/331 (9%) Query: 7 HDARHLLTDACLSLGLTLEAMRAEMSAFDPRIQQARPHAGQIKTAEVIRTLLQGSTRTTH 66 +DA +L ++ LT+E + + A+DPRI + R H GQI TA+ +R +L GS T Sbjct: 215 YDAINLSKHLDIAASLTMEGLHGIIDAYDPRIGEVRGHLGQINTAKNMRNILAGSKNVTK 274 Query: 67 XRGDPHAPAGFQLPEELRRTDIAYTARIQDVYSLRCAPQVYGPVFDALDYIDTIIEKETN 126 G + R+QD Y LRC PQ++G D L+Y+ +E E N Sbjct: 275 Q--------GVE--------------RVQDSYVLRCIPQIHGASKDTLEYVKQKVELELN 312 Query: 127 SATDNPLIFHKEEGEGFEIISGGNFHGQYLAQAMDLLAMAITDLGSICERRIARLIDPTL 186 + TDNP+IF + E+ISGGNFHGQ +A D L +A++++ ++ ERRI ++++P + Sbjct: 313 AVTDNPIIFVDTD----EVISGGNFHGQPMALPFDFLGIALSEMANVSERRIEKMVNPAI 368 Query: 187 SWGLPRNLMSGVRGVNTGYPVVQCSMSSLVMENRTLCMPGSVDSIPSKGNSEDHISNSTW 246 + GLP L+ G+N+G+ +VQ S +SLV EN+ L P SVDSIP+ N EDH+S + Sbjct: 369 NNGLPAFLVEK-GGLNSGFMIVQYSAASLVSENKVLAHPASVDSIPTSANQEDHVSMGSV 427 Query: 247 CARKAMTVVQNTQYIVGVEMLLAAQALTMTEALLKDFVLGQGTQAAYAEIRRQIPACLDG 306 A+K+ + +N + ++G+E++ A QA+ + EA K L T+ AY E+R+ I + + Sbjct: 428 AAKKSKDIFENVRKVIGMELITACQAIDLKEAKDK---LSPATKVAYDEVRK-IISYVSE 483 Query: 307 DRWFHDDVEAAHGFVVSGSVRNAVLAAIGEF 337 DR + D+ AA + + + V AIG+ Sbjct: 484 DRPMYIDIHAAEDLIKTNKIVENVEKAIGKL 514 >CC0959 Non COG Length = 509 Score = 211 bits (537), Expect = 2e-54, Method: Compositional matrix adjust. Identities = 127/330 (38%), Positives = 180/330 (54%), Gaps = 35/330 (10%) Query: 8 DARHLLTDACLSLGLTLEAMRAEMSAFDPRIQQARPHAGQIKTAEVIRTLLQGSTRTTHX 67 +A L A ++ L+ EA + + FDPRI R H GQI+TA +R L+ S Sbjct: 210 EAERLFQSALVTGALSTEAAKGSDTPFDPRIHTLRRHVGQIETAAALRALMSAS------ 263 Query: 68 RGDPHAPAGFQLPEELRRTDIAYTARIQDVYSLRCAPQVYGPVFDALDYIDTIIEKETNS 127 E+R + + R+QD Y LRC PQV G D L T + E N Sbjct: 264 --------------EIRASHLKEDERVQDPYCLRCQPQVMGAALDILRQAATTLATEANC 309 Query: 128 ATDNPLIFHKEEGEGFEIISGGNFHGQYLAQAMDLLAMAITDLGSICERRIARLIDPTLS 187 +DNPLIF E E +SGGNFH + +A A D++A+A+ ++GSI ERRIA L+DP LS Sbjct: 310 VSDNPLIFP----EADEALSGGNFHAEPVAFAADMIALAVCEIGSIAERRIAMLVDPALS 365 Query: 188 WGLPRNLMSGVRGVNTGYPVVQCSMSSLVMENRTLCMPGSVDSIPSKGNSEDHISNSTWC 247 GLP ++ G+N+G+ + Q + ++LV EN+ P SVDSIP+ N EDH+S + Sbjct: 366 -GLP-AFLTPKPGLNSGFMIPQVTAAALVSENKQRAYPASVDSIPTSANQEDHVSMAAHG 423 Query: 248 ARKAMTVVQNTQYIVGVEMLLAAQALTMTEALLKDFVLGQGTQAAYAEIRRQIPACLDGD 307 AR+ + +V+N ++G+E+L AAQ L L +A A R ++P D D Sbjct: 424 ARRLLAMVENADAVLGIELLAAAQGCDFHAPLRSSAAL----EAVRALTRSKVPHLSD-D 478 Query: 308 RWFHDDVEAAHGFVVSGSVRNAVLAAIGEF 337 R FH D+EAA+ V SG AV+AA+G Sbjct: 479 RHFHPDMEAANTLVRSG----AVIAAVGAL 504 >TVN1353 [E] COG2986 Histidine ammonia-lyase Tvo Thermoplasma volcanium Length = 495 Score = 211 bits (537), Expect = 2e-54, Method: Compositional matrix adjust. Identities = 124/326 (38%), Positives = 178/326 (54%), Gaps = 36/326 (11%) Query: 4 LAAHDARHLLTDACLSLGLTLEAMRAEMSAFDPRIQQARPHAGQIKTAEVIRTLLQGSTR 63 L A + +A S L+ EA+R AF I ARPH GQI AE +R L GS Sbjct: 205 LVTSRAYRTIENAVRSSLLSFEALRGTSKAFSDWIVSARPHLGQIAIAEKMRKYLAGS-- 262 Query: 64 TTHXRGDPHAPAGFQLPEELRRTDIAYTARIQDVYSLRCAPQVYGPVFDALDYIDTIIEK 123 + + ++D ++QD Y+LRC PQVYG V D L+Y+ +++ Sbjct: 263 -----------------KNVEKSD---KEKVQDAYTLRCIPQVYGAVLDTLEYVSSVLVT 302 Query: 124 ETNSATDNPLIFHKEEGEGFEIISGGNFHGQYLAQAMDLLAMAITDLGSICERRIARLID 183 E NSATDNPL G E++SGGNFHG+ +A A D L++A+TD+G++ ERRIARL+D Sbjct: 303 EINSATDNPLF------NGKEVVSGGNFHGEPIALAADFLSIALTDMGNMIERRIARLVD 356 Query: 184 PTLSWGLPRNLMSGVRGVNTGYPVVQCSMSSLVMENRTLCMPGSVDSIPSKGNSEDHISN 243 LS GLP L+ G+N+GY + Q + ++L N+ L P S DSIP+ N EDH+S Sbjct: 357 TNLS-GLPPFLVKN-SGLNSGYMIPQYTAAALCNRNKVLSYPSSADSIPTSANQEDHVSM 414 Query: 244 STWCARKAMTVVQNTQYIVGVEMLLAAQALTMTEALLKDFVLGQGTQAAYAEIRRQIPAC 303 + K + + +N +YIV +E LL AQAL ++ + T+A Y +IR + Sbjct: 415 GSTSTLKLLEIEENLEYIVAIEFLLGAQALEFSQDPISPV-----TKAIYTKIREYVKP- 468 Query: 304 LDGDRWFHDDVEAAHGFVVSGSVRNA 329 LD DR + D+E + + NA Sbjct: 469 LDKDRPSYLDIEKIREIMNKNELINA 494 >Ta0242 [E] COG2986 Histidine ammonia-lyase Tac Thermoplasma acidophilum Length = 496 Score = 210 bits (535), Expect = 4e-54, Method: Compositional matrix adjust. Identities = 122/315 (38%), Positives = 177/315 (56%), Gaps = 39/315 (12%) Query: 1 VAILAAHDARHLLTDACLSLGLTLEAMRAEMSAFDPRIQQARPHAGQIKTAEVIRTLLQG 60 +A++ AHD +L +A S L+ EA+ AF P I ARPH GQ+ R L G Sbjct: 205 IAVMDAHD---ILENAIRSALLSFEALGGTSKAFTPWILGARPHLGQVAIGNRFREYLTG 261 Query: 61 STRTTHXRGDPHAPAGFQLPEELRRTDIAYTARIQDVYSLRCAPQVYGPVFDALDYIDTI 120 S + ++R D + ++QD Y+LRC PQVYG V D +DY++ + Sbjct: 262 S-------------------DIVKRAD---SVKVQDAYTLRCIPQVYGSVADVIDYVENV 299 Query: 121 IEKETNSATDNPLIFHKEEGEGFEIISGGNFHGQYLAQAMDLLAMAITDLGSICERRIAR 180 + E NSATDNPL G E++SGGNFHG+ +A A D LA+A+TDLG++ ERRIAR Sbjct: 300 LSVEINSATDNPLF------NGEEVVSGGNFHGEPVALAADFLAIALTDLGNMVERRIAR 353 Query: 181 LIDPTLSWGLPRNLMSGVRGVNTGYPVVQCSMSSLVMENRTLCMPGSVDSIPSKGNSEDH 240 L+D LS GLP ++ G+N+GY + Q + ++L N+ L P S D+IP+ N EDH Sbjct: 354 LVDTNLS-GLPP-FLTPDSGLNSGYMIPQYTAAALCNRNKVLAYPSSADTIPTSANQEDH 411 Query: 241 ISNSTWCARKAMTVVQNTQYIVGVEMLLAAQALTMTEALLKDFVLGQGTQAAYAEIRRQI 300 +S + K + ++ N +YI+ +E LL +QAL T D + T+ Y +IR ++ Sbjct: 412 VSMGATGSLKLLEIIDNVRYIIAIEYLLGSQALEFT-----DKGMSPSTRKIYEKIREKV 466 Query: 301 PACLDGDRWFHDDVE 315 LD DR D+E Sbjct: 467 EK-LDHDRPPSFDIE 480