BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0039.0255.p (349 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RC0457 [MG] COG1086 Predicted nucleoside-diphosphate sugar epime... 436 e-122 RP333 [MG] COG1086 Predicted nucleoside-diphosphate sugar epimer... 435 e-122 SA0148 [MG] COG1086 Predicted nucleoside-diphosphate sugar epime... 411 e-114 PM1007 [MG] COG1086 Predicted nucleoside-diphosphate sugar epime... 396 e-110 SP0358 [MG] COG1086 Predicted nucleoside-diphosphate sugar epime... 393 e-109 >RC0457 [MG] COG1086 Predicted nucleoside-diphosphate sugar epimerases Rco Rickettsia conorii Length = 341 Score = 436 bits (1120), Expect = e-122, Method: Compositional matrix adjust. Identities = 208/340 (61%), Positives = 268/340 (78%), Gaps = 4/340 (1%) Query: 7 FQNATILITGGTGSFGNALLD-LLKN---SQVGQIRIFSRDELKQELMRIRYNDPRLRFY 62 F + T++ITGGTGSFGNA+L LK+ + + +IRIFSRDE KQE MRI N+P+L+FY Sbjct: 2 FVDKTLMITGGTGSFGNAVLSRFLKSGIINDIKEIRIFSRDEKKQEDMRIALNNPKLKFY 61 Query: 63 IGDVRDRASLDGAMSGVDYVFHAAALKQVPSCEFFPMQAVQTNVIGSMNVVESAIKNNVK 122 IGDVR+ S+D AM GVDYVFHAAALKQVP+CEF+PM+A+ TNV+G+ NV+ +AI N V Sbjct: 62 IGDVRNYKSIDEAMHGVDYVFHAAALKQVPTCEFYPMEAINTNVLGAENVLSAAINNKVT 121 Query: 123 KAVFLSTDKAVYPVNAMGMTKALMEKITGAAARAAVEGNTVLSSVRYGNVMYSRGSVIPL 182 K + LSTDKAVYP+NAMG++KALMEK+ A AR G TVL RYGNVM SRGSVIPL Sbjct: 122 KVIVLSTDKAVYPINAMGLSKALMEKLAIAKARMRSPGETVLCVTRYGNVMASRGSVIPL 181 Query: 183 FIEQIKAGKPLTLTVPEMTRFLLPLPHAIELVTFAFQHANQGDLFVKKAPACTVQMLAQA 242 FI QIK GK LT+T P MTRFL+ L +++LV +AF+H +QGD+FV+K+PA T+++LA+A Sbjct: 182 FINQIKQGKVLTITEPSMTRFLMSLVDSVDLVLYAFEHGHQGDIFVQKSPASTIEVLAKA 241 Query: 243 LLELFGSSVPLKVIGMRHGEKIYETLATREELAKAEDMGDYYRVPMDDRDLNYGKYFTEG 302 L ++F S ++ IG RHGEK YE+L + EE+AKA+D+ DYYR+PMD RDLNY KYF EG Sbjct: 242 LQDIFDSKNEIRFIGTRHGEKHYESLVSSEEMAKADDLRDYYRIPMDGRDLNYAKYFVEG 301 Query: 303 DTKEPTLDDYHSHNTQQLDLQEVKQLLLTLPQVRAELQAA 342 + K L+DY SHNT++L+L+EVK+LLLTL V+ EL+ A Sbjct: 302 EKKVALLEDYTSHNTKRLNLEEVKELLLTLDYVQEELKNA 341 >RP333 [MG] COG1086 Predicted nucleoside-diphosphate sugar epimerases Rpr Rickettsia prowazekii Length = 341 Score = 435 bits (1119), Expect = e-122, Method: Compositional matrix adjust. Identities = 207/340 (60%), Positives = 266/340 (78%), Gaps = 4/340 (1%) Query: 7 FQNATILITGGTGSFGNALLD-LLKNS---QVGQIRIFSRDELKQELMRIRYNDPRLRFY 62 F + T++ITGGTGSFGNA+L LK++ + +IRIFSRDE KQE MRI N+ +L+FY Sbjct: 2 FVDKTLMITGGTGSFGNAVLSRFLKSNIINDIKEIRIFSRDEKKQEDMRIALNNSKLKFY 61 Query: 63 IGDVRDRASLDGAMSGVDYVFHAAALKQVPSCEFFPMQAVQTNVIGSMNVVESAIKNNVK 122 IGDVR+ S+D AM GVDYVFHAAALKQVP+CEF+PM+A+ TNV+G+ NV+ +AI N V Sbjct: 62 IGDVRNYQSIDDAMHGVDYVFHAAALKQVPTCEFYPMEAINTNVLGAENVLSAAINNKVT 121 Query: 123 KAVFLSTDKAVYPVNAMGMTKALMEKITGAAARAAVEGNTVLSSVRYGNVMYSRGSVIPL 182 K + LSTDKAVYP+NAMG++KALMEK+ A AR G T+L RYGNVM SRGSVIPL Sbjct: 122 KVIVLSTDKAVYPINAMGLSKALMEKLAIAKARMRSPGETILCVTRYGNVMASRGSVIPL 181 Query: 183 FIEQIKAGKPLTLTVPEMTRFLLPLPHAIELVTFAFQHANQGDLFVKKAPACTVQMLAQA 242 FI QIK GK LT+T P MTRFL+ L +++LV +AF+H QGD+FV+K+PA T+++LA+A Sbjct: 182 FIHQIKQGKELTITEPSMTRFLMSLVDSVDLVLYAFEHGRQGDIFVQKSPASTIEVLAKA 241 Query: 243 LLELFGSSVPLKVIGMRHGEKIYETLATREELAKAEDMGDYYRVPMDDRDLNYGKYFTEG 302 L E+FGS ++ IG RHGEK YE+L + E++AKA+D+G YYR+PMD RDLNY KYF G Sbjct: 242 LQEIFGSKNAIRFIGTRHGEKHYESLVSSEDMAKADDLGGYYRIPMDGRDLNYAKYFVTG 301 Query: 303 DTKEPTLDDYHSHNTQQLDLQEVKQLLLTLPQVRAELQAA 342 + K LDDY SHNT++L+L+EVK+LLLTL V+ EL+ A Sbjct: 302 EKKVALLDDYTSHNTKRLNLKEVKELLLTLDYVQKELKNA 341 >SA0148 [MG] COG1086 Predicted nucleoside-diphosphate sugar epimerases Sau Staphylococcus aureus N315 Length = 342 Score = 411 bits (1056), Expect = e-114, Method: Compositional matrix adjust. Identities = 197/334 (58%), Positives = 252/334 (75%) Query: 7 FQNATILITGGTGSFGNALLDLLKNSQVGQIRIFSRDELKQELMRIRYNDPRLRFYIGDV 66 F + +LITGGTGSFGNA++ +S + +IRIFSRDE KQ+ +R +YN+ +L+FYIGDV Sbjct: 2 FDDKILLITGGTGSFGNAVMKRFLDSNIKEIRIFSRDEKKQDDIRKKYNNSKLKFYIGDV 61 Query: 67 RDRASLDGAMSGVDYVFHAAALKQVPSCEFFPMQAVQTNVIGSMNVVESAIKNNVKKAVF 126 RD S++ AM VDYVFHAAALKQVPSCEFFP++AV+TN+IG+ NV++SAI NVKK + Sbjct: 62 RDSQSVETAMRDVDYVFHAAALKQVPSCEFFPVEAVKTNIIGTENVLQSAIHQNVKKVIC 121 Query: 127 LSTDKAVYPVNAMGMTKALMEKITGAAARAAVEGNTVLSSVRYGNVMYSRGSVIPLFIEQ 186 LSTDKA YP+NAMG++KA+MEK+ A +R T++ RYGNVM SRGSVIPLFI++ Sbjct: 122 LSTDKAAYPINAMGISKAMMEKVFVAKSRNIRSEQTLICGTRYGNVMASRGSVIPLFIDK 181 Query: 187 IKAGKPLTLTVPEMTRFLLPLPHAIELVTFAFQHANQGDLFVKKAPACTVQMLAQALLEL 246 IKAG+PLT+T P+MTRFL+ L A+ELV AF+HA GD+ V+KAP+ TV LA ALLEL Sbjct: 182 IKAGEPLTITDPDMTRFLMSLEDAVELVVHAFKHAETGDIMVQKAPSSTVGDLATALLEL 241 Query: 247 FGSSVPLKVIGMRHGEKIYETLATREELAKAEDMGDYYRVPMDDRDLNYGKYFTEGDTKE 306 F + +++IG RHGEK ETL TREE A+ EDMGDY+RVP D RDLNY Y G+ K Sbjct: 242 FEADNAIEIIGTRHGEKKAETLLTREEYAQCEDMGDYFRVPADSRDLNYSNYVETGNEKI 301 Query: 307 PTLDDYHSHNTQQLDLQEVKQLLLTLPQVRAELQ 340 +Y+S NT L ++E+K+ LLTL VR EL Sbjct: 302 TQSYEYNSDNTHILTVEEIKEKLLTLEYVRNELN 335 >PM1007 [MG] COG1086 Predicted nucleoside-diphosphate sugar epimerases Pmu Pasteurella multocida Length = 344 Score = 396 bits (1017), Expect = e-110, Method: Compositional matrix adjust. Identities = 183/327 (55%), Positives = 250/327 (76%), Gaps = 1/327 (0%) Query: 7 FQNATILITGGTGSFGNALLDLLKNSQVGQIRIFSRDELKQELMRIRYNDPRLRFYIGDV 66 F+N T+LITGGTGSFGNA+L + + +IR+FSRDE KQ+ MR +YND +L+FYIGDV Sbjct: 2 FKNKTLLITGGTGSFGNAVLKRFLETDIREIRVFSRDEKKQDDMRKKYNDAKLKFYIGDV 61 Query: 67 RDRASLDGAMSGVDYVFHAAALKQVPSCEFFPMQAVQTNVIGSMNVVESAIKNNVKKAVF 126 RD S+ A GVDY++HAAALKQVPSCEF+P++AV+TN++G+ NV+E+AI+N +K+ V Sbjct: 62 RDYDSILNASRGVDYIYHAAALKQVPSCEFYPLEAVKTNILGTANVLEAAIQNQIKRVVC 121 Query: 127 LSTDKAVYPVNAMGMTKALMEKITGAAARAAVEGNTVLSSVRYGNVMYSRGSVIPLFIEQ 186 LSTDKAVYP+NAMG++KA+MEK+ A +R T + RYGNVM SRGSVIPLF++Q Sbjct: 122 LSTDKAVYPINAMGISKAMMEKVIIAKSRNLEGTPTTICCTRYGNVMASRGSVIPLFVDQ 181 Query: 187 IKAGKPLTLTVPEMTRFLLPLPHAIELVTFAFQHANQGDLFVKKAPACTVQMLAQALLEL 246 I+ GKP T+T PEMTRF++ L A++LV +AF++ GD+FV+KAPA T+ LA+A+ EL Sbjct: 182 IRQGKPFTITDPEMTRFMMTLEDAVDLVLYAFKNGQNGDVFVQKAPAATIGTLAKAITEL 241 Query: 247 FG-SSVPLKVIGMRHGEKIYETLATREELAKAEDMGDYYRVPMDDRDLNYGKYFTEGDTK 305 + P+ +IG RHGEK +E L +REE+ A + G+YYR+P D R LNY KY +G+ K Sbjct: 242 LSVPNHPISIIGTRHGEKAFEALLSREEMVHAINEGNYYRIPADQRSLNYSKYVEKGEPK 301 Query: 306 EPTLDDYHSHNTQQLDLQEVKQLLLTL 332 + DY+SHNT++L ++E+KQLLL L Sbjct: 302 ITEVTDYNSHNTERLTVKEMKQLLLKL 328 >SP0358 [MG] COG1086 Predicted nucleoside-diphosphate sugar epimerases Spn Streptococcus pneumoniae TIGR4 Length = 351 Score = 393 bits (1010), Expect = e-109, Method: Compositional matrix adjust. Identities = 186/342 (54%), Positives = 252/342 (73%), Gaps = 6/342 (1%) Query: 5 ADFQNATILITGGTGSFGNALLDLLKNSQVGQIRIFSRDELKQELMRIRYN------DPR 58 + F T+LITGGTGSFGNA+L + V +IRIFSRDE KQ+ MR + + Sbjct: 2 SQFTGKTLLITGGTGSFGNAVLKRFLETDVSEIRIFSRDEKKQDDMRHEFQVKVPEVAGK 61 Query: 59 LRFYIGDVRDRASLDGAMSGVDYVFHAAALKQVPSCEFFPMQAVQTNVIGSMNVVESAIK 118 +RFY+GDVRD AS+ AM GVDYVFHAAALKQVPSCEFFP++AV+TN++G+ NV+ +AI+ Sbjct: 62 IRFYLGDVRDLASVKNAMHGVDYVFHAAALKQVPSCEFFPVEAVKTNILGTENVLTAAIE 121 Query: 119 NNVKKAVFLSTDKAVYPVNAMGMTKALMEKITGAAARAAVEGNTVLSSVRYGNVMYSRGS 178 VK+ + LSTDKA YPVNAMG +KA+MEKI A +R +T + RYGNV+ SRGS Sbjct: 122 AGVKQVICLSTDKAAYPVNAMGTSKAMMEKIAVAKSRTVNPEHTKICVTRYGNVLCSRGS 181 Query: 179 VIPLFIEQIKAGKPLTLTVPEMTRFLLPLPHAIELVTFAFQHANQGDLFVKKAPACTVQM 238 V+PL+IEQIK G LT+T P MTRF++ L A++LV FAF+ GD+ V+KAPACT+++ Sbjct: 182 VVPLWIEQIKQGNALTITEPSMTRFVMTLEEAVDLVLFAFEEGKSGDILVQKAPACTIEV 241 Query: 239 LAQALLELFGSSVPLKVIGMRHGEKIYETLATREELAKAEDMGDYYRVPMDDRDLNYGKY 298 LA+A+ E+F S +K+IG+RHGEK YETL T EE A A D+GD+YRVP D+R+LNY KY Sbjct: 242 LAKAVSEIFASEQDIKIIGIRHGEKRYETLLTNEECANAIDLGDFYRVPSDNRNLNYDKY 301 Query: 299 FTEGDTKEPTLDDYHSHNTQQLDLQEVKQLLLTLPQVRAELQ 340 F +G T L +++S+NT +D+++VK+ LL L +++ ++ Sbjct: 302 FKDGSTNRNLLTEFNSNNTDLMDVEQVKRKLLELDEIQTAIR 343