BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0039.0226.p (351 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value CC2868 [M] COG2089 Sialic acid synthase Ccr Caulobacter vibrioides 386 e-107 CAC2187 [M] COG2089 Sialic acid synthase Cac Clostridium acetobu... 371 e-102 Cj1317 [M] COG2089 Sialic acid synthase Cje Campylobacter jejuni 271 1e-72 HP0178 [M] COG2089 Sialic acid synthase Hpy Helicobacter pylori ... 271 2e-72 jhp0166 [M] COG2089 Sialic acid synthase jHp Helicobacter pylori... 261 1e-69 >CC2868 [M] COG2089 Sialic acid synthase Ccr Caulobacter vibrioides Length = 356 Score = 386 bits (992), Expect = e-107, Method: Compositional matrix adjust. Identities = 191/347 (55%), Positives = 243/347 (70%), Gaps = 3/347 (0%) Query: 4 FHIANRGIGSTYPPFVIAEMSGNHNQSLQRALDIVDAAARAGAHAIKLQTYTADTMTLNL 63 IA R IG+ + P+VI E+SGNHN SL+R L +VDAAA G AIK+QTYTADT+TL++ Sbjct: 12 IEIAGRKIGADHSPYVICELSGNHNGSLERCLAMVDAAADTGCDAIKIQTYTADTITLDV 71 Query: 64 DQGDFRINDPDSLWSGRTLYSLYDEAHTPWEWHKPLFERAQAHGMIAFSTPFDESAVDFL 123 D+ +F+I+ LW GRTLY LY+EAHTP+EWH +FERA+ G+ FS+PFDE+AVD L Sbjct: 72 DRPEFKIHG--GLWDGRTLYELYEEAHTPFEWHAAIFERARQRGVTIFSSPFDETAVDLL 129 Query: 124 EQLNAPCYKIASFENTDLPLIRKVASTGKPMIISTGMASIAELDETVRAAREAGCRDLVL 183 + L AP +KIASFE DLPLI+ A+ GKP+IISTGMA++ E+ + A AG ++L Sbjct: 130 DSLGAPAFKIASFEAVDLPLIKYAAAKGKPLIISTGMANLTEMQTALDTALSAGAPGVLL 189 Query: 184 LKCTSTYPATPENTNVRTIAHMRDLFGCQIGLSDHTMGCGTSVAAVAFGATVIEKHFTLS 243 L C S+YPAT + NVRT+ M FGC IGLSDHT G SVAAV+ GA +EKHFTL+ Sbjct: 190 LHCVSSYPATFADANVRTVPDMAARFGCPIGLSDHTPGTAASVAAVSLGACAVEKHFTLA 249 Query: 244 RADGGVDSTFSLEPEEMQQLVVETTRAWQSLGEVRYGIQSASEGKSKIFRRSLYVVEDVP 303 RADGG D+ FSLEP E + LV +T AW +LG Y + SE S +FRRSLYV DV Sbjct: 250 RADGGPDAAFSLEPAEFKALVDDTKNAWAALGRAHYDVL-GSEATSLLFRRSLYVTADVK 308 Query: 304 AGAMLTPDNVRAIRPGFGMPPKFLPQVLGRTARHDIPRGTALNWDLM 350 AG LT NVR++RPG G+PP L +VL A D+ RG L+W ++ Sbjct: 309 AGEPLTRANVRSVRPGNGLPPADLDKVLAGKATRDLARGEPLDWSMV 355 >CAC2187 [M] COG2089 Sialic acid synthase Cac Clostridium acetobutylicum Length = 350 Score = 371 bits (953), Expect = e-102, Method: Compositional matrix adjust. Identities = 173/351 (49%), Positives = 244/351 (69%), Gaps = 3/351 (0%) Query: 1 MNE-FHIANRGIGSTYPPFVIAEMSGNHNQSLQRALDIVDAAARAGAHAIKLQTYTADTM 59 MN+ I + IG F+IAEMS NHNQ RA++I+ AA R+GA AIKLQTYT DT+ Sbjct: 1 MNKVIDIGGKKIGEGQRTFIIAEMSANHNQDFDRAVEIIKAAKRSGADAIKLQTYTPDTI 60 Query: 60 TLNLDQGDFRINDPDSLWSGRTLYSLYDEAHTPWEWHKPLFERAQAHGMIAFSTPFDESA 119 T + D F+I ++W G TL+ LY+EA+TPW+W L E A+ G+I FS+PFD ++ Sbjct: 61 TFDSDNEYFQIKQ-GTIWDGTTLHKLYEEAYTPWQWQPKLKEIAEEEGLICFSSPFDNTS 119 Query: 120 VDFLEQLNAPCYKIASFENTDLPLIRKVASTGKPMIISTGMASIAELDETVRAAREAGCR 179 VDFLE++ P YK+ASFE TD+P I +AS GKP+I+STG+A + E+ E V A R G Sbjct: 120 VDFLEKMEVPAYKVASFELTDIPFIEYIASKGKPVIMSTGIAEMGEIYEAVAACRRQGNE 179 Query: 180 DLVLLKCTSTYPATPENTNVRTIAHMRDLFGCQIGLSDHTMGCGTSVAAVAFGATVIEKH 239 +++LLKC+S+YP+ E+ N++TI +MR+ F C +GLSDHTMG + AAVA GATVIEKH Sbjct: 180 NVILLKCSSSYPSPLEDINLKTIPNMREAFNCSVGLSDHTMGYSVATAAVALGATVIEKH 239 Query: 240 FTLSRADGGVDSTFSLEPEEMQQLVVETTRAWQSLGEVRYGIQSASEGKSKIFRRSLYVV 299 FTL R+DGG DS FS+EPEE +V ++LG+V Y + + + S+ RSL+VV Sbjct: 240 FTLKRSDGGPDSAFSMEPEEFSAMVKSIREVEKALGKVTYEL-TEKQKNSRQHSRSLFVV 298 Query: 300 EDVPAGAMLTPDNVRAIRPGFGMPPKFLPQVLGRTARHDIPRGTALNWDLM 350 +D+ G T +NV++IRP FG+ K++ +V+G+ AR D+ +GT L+W+L+ Sbjct: 299 KDIKKGETFTKENVKSIRPAFGLKTKYIEEVIGKKARVDVKKGTPLDWNLL 349 >Cj1317 [M] COG2089 Sialic acid synthase Cje Campylobacter jejuni Length = 343 Score = 271 bits (694), Expect = 1e-72, Method: Compositional matrix adjust. Identities = 146/329 (44%), Positives = 207/329 (62%), Gaps = 3/329 (0%) Query: 18 FVIAEMSGNHNQSLQRALDIVDAAARAGAHAIKLQTYTADTMTLNLDQGDFRINDPDSLW 77 F+IAE+S NH SL+ AL + AA +AGA AIK+QTYT D++TLN D+ DF I LW Sbjct: 13 FIIAELSANHAGSLEMALKSIKAAKKAGADAIKIQTYTPDSLTLNSDKEDFIIKG--GLW 70 Query: 78 SGRTLYSLYDEAHTPWEWHKPLFERAQAHGMIAFSTPFDESAVDFLEQLNAPCYKIASFE 137 R LY LY+ A TP+EWH +FE AQ G++ FS+PF + V+FL++ + YKIASFE Sbjct: 71 DKRKLYELYESAKTPYEWHSQIFETAQNEGILCFSSPFAKEDVEFLKRFDPIAYKIASFE 130 Query: 138 NTDLPLIRKVASTGKPMIISTGMASIAELDETVRAAREAGCRDLVLLKCTSTYPATPENT 197 D +R +A KP I+STG+A+ EL + +E DLV LKCTSTYP E+ Sbjct: 131 ANDENFVRLIAKEKKPTIVSTGIATEEELFKICEIFKEEKNPDLVFLKCTSTYPTAIEDM 190 Query: 198 NVRTIAHMRDLFGCQIGLSDHTMGCGTSVAAVAFGATVIEKHFTLSRADGGVDSTFSLEP 257 N++ I +++ F ++GLSDH+ G V AVA GA VIEKHF L ++ DS FSL+ Sbjct: 191 NLKGIVSLKEKFNVEVGLSDHSFGFLAPVMAVALGARVIEKHFMLDKSIESEDSKFSLDF 250 Query: 258 EEMQQLVVETTRAWQSLGEVRYGIQSASEGKSKIFRRSLYVVEDVPAGAMLTPDNVRAIR 317 +E + +V +A +LG+ + + K+++F RSLY +D+ G M + +NV+++R Sbjct: 251 DEFKAMVDAVRQAESALGDGKLDLDEKV-LKNRVFARSLYASKDIKKGEMFSEENVKSVR 309 Query: 318 PGFGMPPKFLPQVLGRTARHDIPRGTALN 346 P FG+ PKF ++LG+ A DI G AL Sbjct: 310 PSFGLHPKFYQELLGKKASKDIKFGDALK 338 >HP0178 [M] COG2089 Sialic acid synthase Hpy Helicobacter pylori 26695 Length = 340 Score = 271 bits (693), Expect = 2e-72, Method: Compositional matrix adjust. Identities = 136/333 (40%), Positives = 198/333 (59%), Gaps = 2/333 (0%) Query: 16 PPFVIAEMSGNHNQSLQRALDIVDAAARAGAHAIKLQTYTADTMTLNLDQGDFRINDPDS 75 PP ++AE+S NHNQ L A + + A +GA +KLQTYT MTLN + F I + Sbjct: 4 PPKIVAELSANHNQDLNLAKESLHAIKESGADFVKLQTYTPSCMTLNSKEDPFIIQG--T 61 Query: 76 LWSGRTLYSLYDEAHTPWEWHKPLFERAQAHGMIAFSTPFDESAVDFLEQLNAPCYKIAS 135 LW LY LY +A TP EWH LFE A+ + FS+PF A++ LE LN P YKIAS Sbjct: 62 LWDKENLYELYQKASTPLEWHAELFELARKLDLGIFSSPFSSQALELLESLNCPMYKIAS 121 Query: 136 FENTDLPLIRKVASTGKPMIISTGMASIAELDETVRAAREAGCRDLVLLKCTSTYPATPE 195 FE DL LI K A T KP+I+S+G+A+ EL + + R D+ LLKC S YP+ E Sbjct: 122 FEIVDLDLIEKAARTQKPIILSSGIATHTELQDAISLCRRVNNFDITLLKCVSAYPSKIE 181 Query: 196 NTNVRTIAHMRDLFGCQIGLSDHTMGCGTSVAAVAFGATVIEKHFTLSRADGGVDSTFSL 255 + N+ ++ + ++FG + GLSDHT+G + A GA++IEKHF L+++ DS FS+ Sbjct: 182 DANLLSMVKLGEIFGVKFGLSDHTIGSLCPILATTLGASMIEKHFILNKSLQTPDSAFSM 241 Query: 256 EPEEMQQLVVETTRAWQSLGEVRYGIQSASEGKSKIFRRSLYVVEDVPAGAMLTPDNVRA 315 + + +V ++ +LGE I + K + F RSL+V++D+ G LT +N++A Sbjct: 242 DFNGFKSMVEAIKQSVLALGEEEPRINPKTLEKRRFFARSLFVIKDIQKGEALTENNIKA 301 Query: 316 IRPGFGMPPKFLPQVLGRTARHDIPRGTALNWD 348 +RP G+ PKF ++LG+ A + T L+ D Sbjct: 302 LRPNLGLHPKFYKEILGQKASKFLKANTPLSAD 334 >jhp0166 [M] COG2089 Sialic acid synthase jHp Helicobacter pylori J99 Length = 340 Score = 261 bits (668), Expect = 1e-69, Method: Compositional matrix adjust. Identities = 133/332 (40%), Positives = 197/332 (59%), Gaps = 2/332 (0%) Query: 17 PFVIAEMSGNHNQSLQRALDIVDAAARAGAHAIKLQTYTADTMTLNLDQGDFRINDPDSL 76 P ++AE+S NHNQ L A + + A +GA +KLQTYT MTL+ + F I +L Sbjct: 5 PKIVAELSANHNQDLNLAKESLHAIKESGADFVKLQTYTPSCMTLDSKEDPFIIQG--TL 62 Query: 77 WSGRTLYSLYDEAHTPWEWHKPLFERAQAHGMIAFSTPFDESAVDFLEQLNAPCYKIASF 136 W LY LY +A TP EWH LFE A+ + FS+PF A++ LE L+ P YKIASF Sbjct: 63 WDKENLYGLYQKASTPLEWHAELFELAKKLDLGIFSSPFSSKALELLESLDCPMYKIASF 122 Query: 137 ENTDLPLIRKVASTGKPMIISTGMASIAELDETVRAAREAGCRDLVLLKCTSTYPATPEN 196 E DL LI K A T KP+I+S+G+A+ AEL + + R D+ LLKC S YP+ E+ Sbjct: 123 EIVDLDLIEKAARTQKPIILSSGIATHAELQDAISLCRGVNNFDITLLKCVSAYPSKIED 182 Query: 197 TNVRTIAHMRDLFGCQIGLSDHTMGCGTSVAAVAFGATVIEKHFTLSRADGGVDSTFSLE 256 ++ ++ + + FG + GLSDHT+G + A GA++IEKHF L+++ DS FS++ Sbjct: 183 AHLLSMVKLGETFGVKFGLSDHTIGSLCPILATTLGASMIEKHFILNKSLQTPDSAFSMD 242 Query: 257 PEEMQQLVVETTRAWQSLGEVRYGIQSASEGKSKIFRRSLYVVEDVPAGAMLTPDNVRAI 316 + +V ++ +LGE I + + + F RSL+V++D+ G LT DN++A+ Sbjct: 243 FNGFKSMVGAIKQSVLALGEEEPKINPKTLEERRFFARSLFVIKDIQKGEALTSDNIKAL 302 Query: 317 RPGFGMPPKFLPQVLGRTARHDIPRGTALNWD 348 RP G+ PKF ++LG+ A + T L+ D Sbjct: 303 RPNLGLHPKFYKEILGQKASKFLKANTPLSAD 334