BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0039.0222.p (493 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value jhp1129 [V] COG1132 ABC-type multidrug transport system, ATPase ... 194 5e-49 HP1206 [V] COG1132 ABC-type multidrug transport system, ATPase a... 193 8e-49 Cj1130c [V] COG1132 ABC-type multidrug transport system, ATPase ... 154 3e-37 BS_ygaD [V] COG1132 ABC-type multidrug transport system, ATPase ... 127 6e-29 mll5254 [V] COG1132 ABC-type multidrug transport system, ATPase ... 127 6e-29 >jhp1129 [V] COG1132 ABC-type multidrug transport system, ATPase and permease components jHp Helicobacter pylori J99 Length = 578 Score = 194 bits (492), Expect = 5e-49, Method: Compositional matrix adjust. Identities = 137/495 (27%), Positives = 232/495 (46%), Gaps = 27/495 (5%) Query: 2 VVASFAEVLSLGAVMPFLGVLTSPDKVYAHPAAQSVIQLLGITAPSQLLLPLTLAFAVAA 61 V +SF EV+SL +MPF+ + + P + + V ++P +L+ + Sbjct: 41 VFSSFVEVMSLTLLMPFITLASDPSRALDDKDWKMVYDFFHFSSPVRLMYFFSFCLVGIY 100 Query: 62 LLNGAMRLLLLWSSTRMSVLTGADLSIDIYQRTLYQPYSLHISRNSSEIINAISTKTGVT 121 L + + R S + ++ + + Y H++ N + + I+ K Sbjct: 101 LFRMFYGVFFTYLRGRFSNKKAYQIKQQLFLQHIKNNYLSHLNHNLDSLRDIINNKAEGM 160 Query: 122 IHVLLMILNLLSSIVILGAILLALLAVDTKIALVSMGGFALIYGGVIFFTRRSLL----E 177 L+LL+ I ++ L+ + KI LV F I IFF + + + Sbjct: 161 FMSFNAFLSLLTEITVIVFFYSTLILTNWKITLV----FTTILALQIFFIVKKVTVLIKK 216 Query: 178 NSELVARETSLVIKSLQEGLGGIRDVLLDGSQALYCEIYRQSDTRARTAQGNSSFLASAP 237 E+ A+ + +K + + L + +++ ++ +A + S L P Sbjct: 217 KGEMAAKSKAQTLKVFSKFFSNFKITKLKDNHEEAHKLFGENSRKAHDTEIIYSTLQVVP 276 Query: 238 RFAVEALAM-LFIAGLAYFLALEPDGIVRAI-PVLGALALGAQRLLPIMQQAFASWASIK 295 R+++E + L I +AY L G R + P + AL R+LP + + + I Sbjct: 277 RYSIETVGFSLLILAVAYILF--KYGEARMVLPTISMYALALYRILPSVTGVISYYNEIA 334 Query: 296 SNQASLSDAMDLLEQPLPDWAGTAAPTPIPFERDIGLKHLSFSYNQQGPMVLADLNLTIP 355 NQ A +++ + L P+ F I L+++SF+Y + P VL + NLTI Sbjct: 335 YNQL----ATNVVFKSLSKTIVEEDLVPLDFNEKITLQNISFAYKSKHP-VLKNFNLTIQ 389 Query: 356 RGARIGFIGPTGSGKSTLLDIIMGLLCATDGELQIDGQPITETNRRAWQAHLAHVPQSVF 415 +G +I IG +G GKSTL DIIMGL GE+ ID +T NRR+W+ + ++PQ+++ Sbjct: 390 KGQKIALIGHSGCGKSTLADIIMGLTYPKSGEIFIDNTLLTSENRRSWRKKIGYIPQNIY 449 Query: 416 LADTSIEENIAFGVPKHMIDRERVRQAALQAQIAETI---EALPAKYEAMVGERGVRLSG 472 L D ++ +NIAFG ID +R+ + A I + + E L + VGE G +LSG Sbjct: 450 LFDGTVGDNIAFGSA---IDEKRLIKVCKMAHIYDFLCEHEGLKTQ----VGEGGAKLSG 502 Query: 473 GQRQRLGIARALYSR 487 GQ+QR+GIARALY Sbjct: 503 GQKQRIGIARALYDN 517 >HP1206 [V] COG1132 ABC-type multidrug transport system, ATPase and permease components Hpy Helicobacter pylori 26695 Length = 578 Score = 193 bits (490), Expect = 8e-49, Method: Compositional matrix adjust. Identities = 134/494 (27%), Positives = 232/494 (46%), Gaps = 25/494 (5%) Query: 2 VVASFAEVLSLGAVMPFLGVLTSPDKVYAHPAAQSVIQLLGITAPSQLLLPLTLAFAVAA 61 V +SF EV+SL +MPF+ + + P++ + V ++P +L+ + Sbjct: 41 VFSSFVEVMSLTLLMPFITLASDPNRALDDKDWKMVYDFFHFSSPVRLMYFFSFCLVGIY 100 Query: 62 LLNGAMRLLLLWSSTRMSVLTGADLSIDIYQRTLYQPYSLHISRNSSEIINAISTKTGVT 121 L + + R S + ++ + + Y H++ N + + I+ K Sbjct: 101 LFRMFYGVSFTYLKGRFSNKKAYQIKQQLFLQHIKSNYLSHLNHNLDSLRDIINNKAEGM 160 Query: 122 IHVLLMILNLLSSIVILGAILLALLAVDTKIALVSMGGFALIYGGVIFFTRRSLL----E 177 L+LL+ I ++ L+ + KI LV F +I IF + + + Sbjct: 161 FMSFNAFLSLLTEITVIVFFYSTLILTNWKITLV----FTMILALQIFLIVKKVTVLIKK 216 Query: 178 NSELVARETSLVIKSLQEGLGGIRDVLLDGSQALYCEIYRQSDTRARTAQGNSSFLASAP 237 E+ A+ + +K + + L + +++ ++ +A + + L P Sbjct: 217 KGEMAAKSKAQTLKVFSKFFSNFKITKLKDNHEEAHKLFGENSRKAHDTEIIYATLQVVP 276 Query: 238 RFAVEALAM-LFIAGLAYFLALEPDGIVRAIPVLGALALGAQRLLPIMQQAFASWASIKS 296 R+++E + L I +AY L + + +P + AL R+LP + + I Sbjct: 277 RYSIETVGFSLLILAVAYILFKYGEAKM-VLPTISMYALALYRILPSVTGMINYYNEIAY 335 Query: 297 NQASLSDAMDLLEQPLPDWAGTAAPTPIPFERDIGLKHLSFSYNQQGPMVLADLNLTIPR 356 NQ A +++ + L P+ F I L+++SF+Y + P VL D NLTI R Sbjct: 336 NQL----ATNMVFKSLSKTIVEEDLVPLDFNEKITLQNISFAYKSKHP-VLKDFNLTIQR 390 Query: 357 GARIGFIGPTGSGKSTLLDIIMGLLCATDGELQIDGQPITETNRRAWQAHLAHVPQSVFL 416 G ++ IG +G GKSTL DIIMGL GE+ ID +T NRR+W+ + ++PQ+++L Sbjct: 391 GQKVALIGHSGCGKSTLADIIMGLTYPKSGEIFIDNTLLTNKNRRSWRKKIGYIPQNIYL 450 Query: 417 ADTSIEENIAFGVPKHMIDRERVRQAALQAQIAETI---EALPAKYEAMVGERGVRLSGG 473 D ++ +NIAFG ID +R+ + A I + + E L + VGE G +LSGG Sbjct: 451 FDGTVGDNIAFGSA---IDEKRLIKVCKMAHIYDFLCEHEGLKTQ----VGEGGAKLSGG 503 Query: 474 QRQRLGIARALYSR 487 Q+QR+GIARALY Sbjct: 504 QKQRIGIARALYDN 517 >Cj1130c [V] COG1132 ABC-type multidrug transport system, ATPase and permease components Cje Campylobacter jejuni Length = 564 Score = 154 bits (390), Expect = 3e-37, Method: Compositional matrix adjust. Identities = 130/495 (26%), Positives = 239/495 (48%), Gaps = 30/495 (6%) Query: 2 VVASFAEVLSLGAVMPFLGVLTSPDKVYAHPAAQSVIQLLGITAPSQLL---LPLTLAFA 58 V SF E ++ VMPF+ + + + S+ + L I ++ + L + + Sbjct: 25 VFISFIETFAISLVMPFITLASDFSYFDRNKYLISLKEYLNIPVFEIIVYFGVGLIVFYV 84 Query: 59 VAALLNGA-MRLLLLWSSTRMSVLTGADLSIDIYQRTLYQPYSLHISRNSSEIINAISTK 117 ALLN LL +S R + + ++ + L Y +N SEI+ +I Sbjct: 85 FRALLNAYYFHLLARFSKGRYHAI-----AYKVFSKFLNINYEKFTQKNQSEILKSI--- 136 Query: 118 TGVTIHVLLMI---LNLLSSIVILGAILLALLAVDTKIALVSMGGFALIYGGVIFFTRRS 174 TG ++ MI L L+S I ++ + +L ++ KI L + F ++ ++ Sbjct: 137 TGEVYNLSTMISSFLLLMSEIFVVLLLYALMLLINYKITLF-LSIFMVLNAFILVKILSP 195 Query: 175 LLENSELVARETSL--VIKSLQEGLGGIRDVLLDGSQALYCEIYR-QSDTRARTAQGNSS 231 +++ + V RE ++ + L L + + L + +++ QS+ ++ N S Sbjct: 196 IIKKAG-VRREEAMKNFFEILNTNLNNFKFIKLKTKEDGVLSLFKAQSEAFSKANITNES 254 Query: 232 FLASAPRFAVEALAMLFIAGLAYFLALEPDGIVRAI-PVLGALALGAQRLLPIMQQAFAS 290 +A+ PR +E + + + FL L+ + + I + L RL+P + S Sbjct: 255 -VAAVPRIYLEGIGFCVLVFIVVFLVLKNESDISGILSTISIFVLALYRLMPSANRIITS 313 Query: 291 WASIKSNQASLSDAMDLLEQPLPDWAGTAAPTPIPFERDIGLKHLSFSYNQQGPMVLADL 350 + + +SL D++ Q L + F +++ + +LSF Y + + +L Sbjct: 314 YHDLLYYHSSL----DIIYQNLRQEEENLGEEKLSFNQELKICNLSFGY-EGKKYLFKNL 368 Query: 351 NLTIPRGARIGFIGPTGSGKSTLLDIIMGLLCATDGELQIDGQPITETNRRAWQAHLAHV 410 NL I +G +I FIG +G GKSTL+D+I+GLL +G++ ID Q + N + ++ + ++ Sbjct: 369 NLNIKKGEKIAFIGESGCGKSTLVDLIIGLLKPKEGQILIDEQELNANNTKNYRQKIGYI 428 Query: 411 PQSVFLADTSIEENIAFGVPKHMIDRERVRQAALQAQIAETIEALPAKYEAMVGERGVRL 470 PQ+++L + SI +NI FG +D E++ + QA + I+ LP + VG+ G L Sbjct: 429 PQNIYLFNDSIAKNITFG---DAVDEEKLNRVIKQANLEHFIKNLPQGVQTKVGDGGSNL 485 Query: 471 SGGQRQRLGIARALY 485 SGGQ+QR+ IARALY Sbjct: 486 SGGQKQRIAIARALY 500 >BS_ygaD [V] COG1132 ABC-type multidrug transport system, ATPase and permease components Bsu Bacillus subtilis Length = 589 Score = 127 bits (319), Expect = 6e-29, Method: Compositional matrix adjust. Identities = 110/392 (28%), Positives = 186/392 (47%), Gaps = 36/392 (9%) Query: 108 SEIINAISTKTGVTIHVLLMILNLLSSIVILGAILLALLAVDTKIALVSMGGFALIYGGV 167 S +IN + I L+ I + +I+I+ +I+L L D K+ L+S+ F L V Sbjct: 132 SRVINDVEQTKDFVITGLMNIWLDMLTILIVISIMLTL---DVKLTLISIVLFPLYGISV 188 Query: 168 IFFT---RRSLLENSELVARETSLVIKSLQEGLGGIRDVLL-DGSQALYCE--------I 215 +F R+ E S+ +A+ + + +Q G+ IR + D QA + E Sbjct: 189 KYFYGRLRKLTRERSQALAQVQGHLHERIQ-GMPVIRSFAIEDHEQAQFNEKNGHFLDKA 247 Query: 216 YRQSDTRARTAQGNSSFLASAPRFAVEALAMLFIAGLAYFLALEPDGIVRAIPVLGALAL 275 R ++ A+T ++ AP ++ IA YF+ P + + +G + Sbjct: 248 IRHTNWNAKTFAVVNTITDLAP--------LIVIACAGYFVINGPLTVGTMVAFVGYI-- 297 Query: 276 GAQRLLPIMQQAFASWASIKSNQASLSDAMDLLEQPLPDWAGTAAPTPIPFER---DIGL 332 R+ +++ S ++ + AS+ + +++P + T P I ++ + Sbjct: 298 --DRMYNPVRRLINSSTTLTQSIASMDRVFEFIDEP---YELTDKPNAIKADQIRGGVEF 352 Query: 333 KHLSFSYNQQGPMVLADLNLTIPRGARIGFIGPTGSGKSTLLDIIMGLLCATDGELQIDG 392 +++SF Y + +L D++L + RG + +G +G GKSTL+ +I T G L IDG Sbjct: 353 QNVSFQYEKDKENILHDVSLKVNRGETVALVGMSGGGKSTLVSLIPRFYDVTSGRLLIDG 412 Query: 393 QPITETNRRAWQAHLAHVPQSVFLADTSIEENIAFGVPKHMIDRERVRQAALQAQIAETI 452 I + R+ + + V Q FL +I ENIA G P + E + +AA A E I Sbjct: 413 TDIRDYEARSLRNQVGMVLQDTFLFSETIRENIAIGKPDATL--EEIIEAAKAANAHEFI 470 Query: 453 EALPAKYEAMVGERGVRLSGGQRQRLGIARAL 484 + P YE VGERGV+LSGGQ+QR+ IAR Sbjct: 471 MSFPEGYETRVGERGVKLSGGQKQRISIARVF 502 >mll5254 [V] COG1132 ABC-type multidrug transport system, ATPase and permease components Mlo Mesorhizobium loti Length = 613 Score = 127 bits (319), Expect = 6e-29, Method: Compositional matrix adjust. Identities = 65/175 (37%), Positives = 101/175 (57%), Gaps = 2/175 (1%) Query: 313 PDWAGTAAPTPIPFERDIGLKHLSFSYNQQGPMVLADLNLTIPRGARIGFIGPTGSGKST 372 P A + + + + ++ +SFSY+ G V++D+ +P G IGP+GSGKST Sbjct: 349 PGHAQSEDMQKLSLDTGLNIRGVSFSYDDSGKAVVSDITFGLPAGKVTALIGPSGSGKST 408 Query: 373 LLDIIMGLLCATDGELQIDGQPITETNRRAWQAHLAHVPQSVFLADTSIEENIAFGVPKH 432 + D+++GLL T G++ +DG I NRR W+ +A+VPQ VFL +I N+ P+ Sbjct: 409 IADMLLGLLEPTAGKILVDGVEIDAGNRRRWRDQVAYVPQDVFLLHDTIAANLRLAAPQA 468 Query: 433 MIDRERVRQAALQAQIAETIEALPAKYEAMVGERGVRLSGGQRQRLGIARALYSR 487 D + A + +E L + E +VG+RGVRLSGG+RQR+ +ARAL + Sbjct: 469 SDD--DLWTVLRAAHAGDFVERLDQRLETVVGDRGVRLSGGERQRIALARALLRK 521