BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0039.0212.p (670 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc2971 Non COG 606 e-173 PA5040 [U] COG4796 Type II secretory pathway, component HofQ Pae... 375 e-103 NMB1812 [U] COG4796 Type II secretory pathway, component HofQ Nm... 366 e-101 NMA0650 [U] COG4796 Type II secretory pathway, component HofQ Nm... 366 e-100 VC2630 [U] COG4796 Type II secretory pathway, component HofQ Vch... 345 3e-94 >RSc2971 Non COG Length = 714 Score = 606 bits (1562), Expect = e-173, Method: Compositional matrix adjust. Identities = 325/685 (47%), Positives = 445/685 (64%), Gaps = 25/685 (3%) Query: 1 LLLMGVLILSAPALAGPRLHALD-IE--ARDEATTLTLRLDQTLPLSQIHHFQLLDPPQL 57 +L++G L+ A+ P +A++ +E + E+T +T+ L T P + F P ++ Sbjct: 29 MLMVGGQALAQQAITAPASNAVERVEQASTGESTVVTVTLKDT-PAQKPVEFSTQQPARI 87 Query: 58 VLDLPDTTLAAGMARQFAASGLLKRVTLASDGERLRLLASLKRPLHYQLQVQDEQVQVAL 117 +D T A G A LL+ ++ G+R R++ L R Y+ +++ Q + L Sbjct: 88 AIDFFGTAFAQGRANYQYGGKLLRAASVVQIGDRTRVVLDLARQSQYKSEIRGNQYVLTL 147 Query: 118 --------SPLPP---QAPTA------LGGIGFQRGSAGEGRLDVDLGSTAPVVQVRQQG 160 +P+P APTA + I F+RG GR+ VDL ++ + + QQG Sbjct: 148 GAAPTASATPVPTFAAPAPTAGVERPSVRNIDFRRGEELAGRVVVDLSTSNSAINIAQQG 207 Query: 161 QRLIVDIGGTTLPTGSARQVEVGDFATPVTQYQAYPYENGVRLAIHAQGLWRYQAVQRGQ 220 Q L+VD G TLP R+ +V DF TPV +A G RL I +G W+Y + Q Sbjct: 208 QNLVVDFAGATLPQSLRRRFDVSDFGTPVQAMRATDNGTGARLVIEPRGNWQYSSYQTDT 267 Query: 221 QLRIDVLPVSTDPHRIAPDKDYQGARLSLNFQNIEVRTALQVLADFTGLNIIASDAVTGQ 280 Q ++V P DP+++ Y+G R+SLNFQNI++R+ LQV ADFT LNI+ SD+VTG Sbjct: 268 QFVVEVRPTKEDPNKLISGPGYRGERMSLNFQNIDIRSLLQVFADFTNLNIVTSDSVTGT 327 Query: 281 LSLRLKDVPWEQALEMILQARGLALQRSGGVLWIAPREEMAARERQELEQKALLADLEPL 340 LSLRLKDVPW+QAL+++L ++GLA +R+G VLW+APR E+A +E+ ELE + + +LEPL Sbjct: 328 LSLRLKDVPWDQALQIVLDSKGLASRRNGNVLWVAPRNELATKEKAELESQQQVTELEPL 387 Query: 341 HAETFQLNYQRADNLRRALGLGEDGTPQANRRASLLSRRGSAMIDSHTNQLLVTDTLAAL 400 ++ F+LNYQRAD++R L + +LS+RGS D+ TNQL V+D + L Sbjct: 388 RSQVFRLNYQRADDVRNMLLGTGGTAGGGAAASRILSKRGSLTSDARTNQLFVSDIPSKL 447 Query: 401 ANVRKLIERIDIAARQVMIEARIVEADDSFARNLGVKLGLAARTQGAALGNSYASVGELS 460 V+ + +IDI RQVMIEARIVEADD+F+RNLG KLG AA+T GA GN+Y++V +S Sbjct: 448 EEVQAFLLKIDIPVRQVMIEARIVEADDTFSRNLGAKLGFAAKTNGAGYGNTYSNV--VS 505 Query: 461 GQTPPAAGTYLREPALGLGAGALAGSAPGSFAFTLFNAAAQRFLNVELSALEAEGRGKIV 520 T A T+ A+ L A + G S A +LFNA A RFL +ELSALEA+GRGKI+ Sbjct: 506 PVTKDA--TWDNSAAVSLPANGINGVNAASVAVSLFNAGAGRFLALELSALEADGRGKII 563 Query: 521 SSPRLVTADQQAALIEQGEEIPYQQSIGSGATATAFKKANLKLEVTPQITPDGNVILDVD 580 SSPR+VTAD ALIEQG E+PYQQ+ SGAT+ +FKKANLKLEVTP+ITPDGNV LDVD Sbjct: 564 SSPRVVTADNIKALIEQGTEVPYQQATSSGATSVSFKKANLKLEVTPKITPDGNVFLDVD 623 Query: 581 VNKDSRGSATPGGLAINTKHIKTKVQVEDGGTVVIGGIYTQTDNEHETRVPLLGEIPLLG 640 VNKDS G+ T G AINTKH++T+V VE+GGTVVIGGIYTQ + +VPLLG+IP+LG Sbjct: 624 VNKDSLGTQTTNGFAINTKHVQTQVLVENGGTVVIGGIYTQNERTDVNKVPLLGDIPVLG 683 Query: 641 ALFRSRNKVRDKTELLIFLTPRIVA 665 LF+S K D+TELL+FLTPR+++ Sbjct: 684 NLFKSTAKTNDRTELLVFLTPRVLS 708 >PA5040 [U] COG4796 Type II secretory pathway, component HofQ Pae Pseudomonas aeruginosa Length = 714 Score = 375 bits (963), Expect = e-103, Method: Compositional matrix adjust. Identities = 254/712 (35%), Positives = 390/712 (54%), Gaps = 65/712 (9%) Query: 4 MGVLILSA---PALAGPRLHALDIEAR-DEATTLTLRLDQTLPLSQIHHFQLLDPPQLVL 59 +G+ +L+A PAL L LD+ A + L L+ D+ P++ + + P ++ L Sbjct: 8 LGIALLAAMFAPALLAADLEKLDVAALPGDRVELKLQFDE--PVAAPRGYTIEQPARIAL 65 Query: 60 DLPDTTLAAGMARQFAASGLLKRVTLASDGERLRLLASLKRPLHYQLQVQDEQVQVAL-- 117 DLP G + + G + VT+ +R RL+ +L Y +V+ + V + Sbjct: 66 DLPGVQNKLGTKNRELSVGNTRSVTVVEAKDRTRLIINLTALSSYTTRVEGNNLFVVVGN 125 Query: 118 ---------------SPLP----------PQAPT--ALGGIGFQRGSAGEGRLDVDLGST 150 SP P P P A+ I FQRG GEG + +DL Sbjct: 126 SPAGASVASAAPVKASPAPASYAQPIKPKPYVPAGRAIRNIDFQRGEKGEGNVVIDLSDP 185 Query: 151 APVVQVRQQGQRLIVDIGGTTLPTGSARQVEVGDFATPVTQYQAYPYENGVRLAIHAQGL 210 +++QG ++ +D T LP +++V DFATPV A + + I GL Sbjct: 186 TLSPDIQEQGGKIRLDFAKTQLPDALRVRLDVKDFATPVQFVNASAQSDRTSITIEPSGL 245 Query: 211 WRYQAVQRGQQLRIDVLPVST-DPHRIAPDK-DYQGARLSLNFQNIEVRTALQVLADFTG 268 + Y Q +L + + P++T D R D Y G +LSLNFQ+I+VR+ LQ++ADFT Sbjct: 246 YDYLVYQTDNRLTVSIKPMTTEDAERRKKDNFAYTGEKLSLNFQDIDVRSVLQLIADFTD 305 Query: 269 LNIIASDAVTGQLSLRLKDVPWEQALEMILQARGLALQRSGGVLWIAPREEMAARERQEL 328 LN++ASD V G ++LRL++VPW+QAL+++L+ +GL ++ G VL +AP +E+AARERQEL Sbjct: 306 LNLVASDTVQGNITLRLQNVPWDQALDLVLKTKGLDKRKLGNVLLVAPADEIAARERQEL 365 Query: 329 EQKALLADLEPLHAETFQLNYQRADNLRRAL-GLGEDGTPQANRRASLLSRRGSAMIDSH 387 E + +A+L PL E Q+NY +A ++ + + DG + RGS +D Sbjct: 366 EAQKQIAELAPLRRELIQVNYAKAADIAKLFQSVTSDGGQEGKEGG-----RGSITVDDR 420 Query: 388 TNQLLVTDTLAALANVRKLIERIDIAARQVMIEARIVEADDSFARNLGVKLGLAARTQGA 447 TN ++ L +R+++ ++DI RQVMIEARIVEA+ + ++LGV+ G A +G Sbjct: 421 TNSIIAYQPQERLDELRRIVSQLDIPVRQVMIEARIVEANVGYDKSLGVRWG-GAYHKGN 479 Query: 448 ALG-----------NSYASVGELSGQ-TPPAAGTYLREPALGLGAGALAGSAPGSFAFTL 495 G + G ++G T P GT + P+ + GA ++ F Sbjct: 480 WSGYGKDGNIGIKDEDGMNCGPIAGSCTFPTTGTS-KSPSPFVDLGAKDATSGIGIGFIT 538 Query: 496 FNAAAQRFLNVELSALEAEGRGKIVSSPRLVTADQQAALIEQGEEIPYQQSIGSGATATA 555 N L+++LSA+E G G+IVS P++VT+D++ A I +G E+PYQ++ SGAT+T+ Sbjct: 539 DNI----ILDLQLSAMEKTGNGEIVSQPKVVTSDKETAKILKGSEVPYQEASSSGATSTS 594 Query: 556 FKKANLKLEVTPQITPDGNVILDVDVNKDS--RGSATPGGLAINTKHIKTKVQVEDGGTV 613 FK+A L LEVTPQITPD +I++V V KD+ + G IN + K+ V DG T+ Sbjct: 595 FKEAALSLEVTPQITPDNRIIVEVKVTKDAPDYQNMLNGVPPINKNEVNAKILVNDGETI 654 Query: 614 VIGGIYTQTDNEHETRVPLLGEIPLLGALFRSRNKVRD-KTELLIFLTPRIV 664 VIGG+++ ++ +VP LGE+P LG LFR R+ V D K ELL+FLTPRI+ Sbjct: 655 VIGGVFSNEQSKSVEKVPFLGELPYLGRLFR-RDTVTDRKNELLVFLTPRIM 705 >NMB1812 [U] COG4796 Type II secretory pathway, component HofQ Nme Neisseria meningitidis MC58 Length = 769 Score = 366 bits (940), Expect = e-101, Method: Compositional matrix adjust. Identities = 211/522 (40%), Positives = 315/522 (60%), Gaps = 27/522 (5%) Query: 156 VRQQGQRLIVDIGGTTLPTGSARQVEVGDFATPVTQYQAYPYENGVRLAIHAQGLWRYQA 215 + QQ +IV + TLPT R ++V DF TPV + N +L I G W + Sbjct: 253 ISQQHDHIIVTLKNHTLPTTLQRSLDVADFKTPVQKVTLKRLNNDTQLIITTAGNW--EL 310 Query: 216 VQRGQ---QLRIDVLPVSTDPH----RIAPDKDYQGARLSLNFQNIEVRTALQVLADFTG 268 V + VLP + AP K + G ++SL+FQ++E+RT LQ+LA +G Sbjct: 311 VNKSAAPGYFTFQVLPKKQNLESGGVNNAP-KTFTGRKISLDFQDVEIRTILQILAKESG 369 Query: 269 LNIIASDAVTGQLSLRLKDVPWEQALEMILQARGLALQRSGGVLWIAPREEMAARERQEL 328 +NI+ASD+V G+++L LKDVPW+QAL++++QAR L +++ G ++ IAPR+E+ A+++ L Sbjct: 370 MNIVASDSVNGKMTLSLKDVPWDQALDLVMQARNLDMRQQGNIVNIAPRDELLAKDKALL 429 Query: 329 EQKALLADLEPLHAETFQLNYQRADNLRRALGLGEDGTPQANRRASLLSRRGSAMIDSHT 388 + + +ADL L+++ FQL Y+ + R L L D R +L+S RGS +ID T Sbjct: 430 QAEKDIADLGALYSQNFQLKYKNVEEFRSILRL--DNADTTGNRNTLISGRGSVLIDPAT 487 Query: 389 NQLLVTDTLAALANVRKLIERIDIAARQVMIEARIVEADDSFARNLGVKLGLAARTQGAA 448 N L+VTDT + + RKLI+ +D+ A+QVMIEARIVEA D F+R+LGVK G + + Sbjct: 488 NTLIVTDTRSVIEKFRKLIDELDVPAQQVMIEARIVEAADGFSRDLGVKFGATGKKK--- 544 Query: 449 LGNSYASVGELSGQTPPAAGTYLREPALGLGAGALAGSAPGSFAFTLFNAAAQRFLNVEL 508 L N ++ G + E + L A A S +L A + LN+EL Sbjct: 545 LKNDTSAFGWGVNSGFGGDDKWGAETKINLPITAAANS------ISLVRAISSGALNLEL 598 Query: 509 SALEAEGRGKIVSSPRLVTADQQAALIEQGEEIPYQ-QSIGSG--ATATAFKKANLKLEV 565 SA E+ + K +++PR++T +++ A IE G EIP+ SI +G +T T KKA L L V Sbjct: 599 SASESLSKTKTLANPRVLTQNRKEAKIESGYEIPFTVTSIANGGSSTNTELKKAVLGLTV 658 Query: 566 TPQITPDGNVILDVDVNKDSRGSATPGG---LAINTKHIKTKVQVEDGGTVVIGGIYTQT 622 TP ITPDG +I+ V +NKDS G L I+TK++ T+ VE+GGT+++GGIY + Sbjct: 659 TPNITPDGQIIMTVKINKDSPAQCASGNQTILCISTKNLNTQAMVENGGTLIVGGIYEED 718 Query: 623 DNEHETRVPLLGEIPLLGALFRSRNKVRDKTELLIFLTPRIV 664 + T+VPLLG+IP++G LF++R K D+ ELLIF+TPRI+ Sbjct: 719 NGNTLTKVPLLGDIPVIGNLFKTRGKKTDRRELLIFITPRIM 760 >NMA0650 [U] COG4796 Type II secretory pathway, component HofQ NmA Neisseria meningitidis Z2491 Length = 761 Score = 366 bits (939), Expect = e-100, Method: Compositional matrix adjust. Identities = 216/553 (39%), Positives = 325/553 (58%), Gaps = 27/553 (4%) Query: 125 PTALGGIGFQRGSAGEGRLDVDLGSTAPVVQVRQQGQRLIVDIGGTTLPTGSARQVEVGD 184 P I F++ G +++ A + QQ +IV + TLPT R ++V D Sbjct: 214 PAKQTNIDFRKDGKNAGIIELAALGFAGQPDISQQHDHIIVTLKNHTLPTTLQRSLDVAD 273 Query: 185 FATPVTQYQAYPYENGVRLAIHAQGLWRYQAVQRGQ---QLRIDVLPVSTDPH----RIA 237 F TPV + N +L I G W + V + VLP + A Sbjct: 274 FKTPVQKVTLKRLNNDTQLIITTAGNW--ELVNKSAAPGYFTFQVLPKKQNLESGGVNNA 331 Query: 238 PDKDYQGARLSLNFQNIEVRTALQVLADFTGLNIIASDAVTGQLSLRLKDVPWEQALEMI 297 P K + G ++SL+FQ++E+RT LQ+LA +G+NI+ASD+V G+++L LKDVPW+QAL+++ Sbjct: 332 P-KTFTGRKISLDFQDVEIRTILQILAKESGMNIVASDSVNGKMTLSLKDVPWDQALDLV 390 Query: 298 LQARGLALQRSGGVLWIAPREEMAARERQELEQKALLADLEPLHAETFQLNYQRADNLRR 357 +QAR L +++ G ++ IAPR+E+ A+++ L+ + +ADL L+++ FQL Y+ + R Sbjct: 391 MQARNLDMRQQGNIVNIAPRDELLAKDKAFLQAEKDIADLGALYSQNFQLKYKNVEEFRS 450 Query: 358 ALGLGEDGTPQANRRASLLSRRGSAMIDSHTNQLLVTDTLAALANVRKLIERIDIAARQV 417 L L D R +L+S RGS +ID TN L+VTDT + + RKLI+ +D+ A+QV Sbjct: 451 ILRL--DNADTTGNRNTLVSGRGSVLIDPATNTLIVTDTRSVIEKFRKLIDELDVPAQQV 508 Query: 418 MIEARIVEADDSFARNLGVKLGLAARTQGAALGNSYASVGELSGQTPPAAGTYLREPALG 477 MIEARIVEA D F+R+LGVK G + + L N ++ G + E + Sbjct: 509 MIEARIVEAADGFSRDLGVKFGATGKKK---LKNDTSAFGWGVNSGFGGDDKWGAETKIN 565 Query: 478 LGAGALAGSAPGSFAFTLFNAAAQRFLNVELSALEAEGRGKIVSSPRLVTADQQAALIEQ 537 L A A S +L A + LN+ELSA E+ + K +++PR++T +++ A IE Sbjct: 566 LPITAAANS------ISLVRAISSGALNLELSASESLSKTKTLANPRVLTQNRKEAKIES 619 Query: 538 GEEIPYQ-QSIGSG--ATATAFKKANLKLEVTPQITPDGNVILDVDVNKDSRGSATPGG- 593 G EIP+ SI +G +T T KKA L L VTP ITPDG +I+ V +NKDS G Sbjct: 620 GYEIPFTVTSIANGGSSTNTELKKAVLGLTVTPNITPDGQIIMTVKINKDSPAQCASGNQ 679 Query: 594 --LAINTKHIKTKVQVEDGGTVVIGGIYTQTDNEHETRVPLLGEIPLLGALFRSRNKVRD 651 L I+TK++ T+ VE+GGT+++GGIY + + T+VPLLG+IP++G LF++R K D Sbjct: 680 TILCISTKNLNTQAMVENGGTLIVGGIYEEDNGNTLTKVPLLGDIPVIGNLFKTRGKKTD 739 Query: 652 KTELLIFLTPRIV 664 + ELLIF+TPRI+ Sbjct: 740 RRELLIFITPRIM 752 >VC2630 [U] COG4796 Type II secretory pathway, component HofQ Vch Vibrio cholerae Length = 578 Score = 345 bits (884), Expect = 3e-94, Method: Compositional matrix adjust. Identities = 202/543 (37%), Positives = 318/543 (58%), Gaps = 18/543 (3%) Query: 128 LGGIGFQRGSAGEGRLDVDLGSTAPVVQVRQQGQRLIVDIGGTTLPTGSARQVEVGDFAT 187 L I F+ L V+L S + VV V++ + L +++ T + ++V DF+T Sbjct: 46 LENIDFRVNKEKAAVLIVELASPSAVVDVQKVQEGLSIELLKTDVADDKLYLLDVKDFST 105 Query: 188 PVTQYQAYPYENGVRLAIHAQGLWRYQAVQRGQQLRIDVLPVSTDPHRIAPDK--DYQGA 245 PV + + E +L + G +++ +G+ L + + + D + P + +G Sbjct: 106 PVESVEVFRKEPSTQLVVTVDGEFQHDYTLKGKYLEVVISKLKAD-EKPKPKSVLEKEGK 164 Query: 246 RLSLNFQNIEVRTALQVLADFTGLNIIASDAVTGQLSLRLKDVPWEQALEMILQARGLAL 305 +S+NFQ+I VR LQ++AD+ G N++ SD+V G L+LRL VPW+Q L++ILQ +GL Sbjct: 165 LISINFQDIPVRNVLQLIADYNGFNLVVSDSVVGNLTLRLDGVPWQQVLDIILQVKGLDK 224 Query: 306 QRSGGVLWIAPREEMAARERQELEQKALLADLEPLHAETFQLNYQRADNLRRALGLGEDG 365 + G V+ IAP+EE+ RE+Q LE+ L +L L +E ++N+ +A ++ +G GE Sbjct: 225 RVDGNVILIAPKEELDLREKQALEKARLAEELGDLKSEIIKINFAKASDIAAMIG-GEGN 283 Query: 366 TPQANRRASLLSRRGSAMIDSHTNQLLVTDTLAALANVRKLIERIDIAARQVMIEARIVE 425 ++LS RGS ID TN LL+ + +A +R++IE +DI +QV IEARIV Sbjct: 284 -------VNMLSERGSISIDERTNSLLIRELPDNIAVIREIIESLDIPVKQVQIEARIVT 336 Query: 426 ADDSFARNLGVKLGLAARTQGAALGNSYASVGELSGQTPPAAGTYLREPALGLGAGALAG 485 + LGV+ G+ + ++G S S L + A + + L + + + Sbjct: 337 VKEGNLEELGVRWGVMSTNGSHSVGGSIES--NLWQKGLLADDEFPVDEFLNVNLASTSA 394 Query: 486 SAPGSFAFTLFNAAAQRFLNVELSALEAEGRGKIVSSPRLVTADQQAALIEQGEEIPYQQ 545 +A S AF + + L++ELSAL+ E + +I+SSPRL+T ++Q A IEQG EIPY + Sbjct: 395 NA-SSIAFQVAKLGSGTLLDLELSALQNESKAEIISSPRLITTNKQPAYIEQGTEIPYLE 453 Query: 546 SIGSGATATAFKKANLKLEVTPQITPDGNVILDVDVNKDSRGSATPGG----LAINTKHI 601 S SGA+ AFKKA L L+VTPQITPD ++LD+ V +D RG G ++I+T+ I Sbjct: 454 SSSSGASTVAFKKAVLSLKVTPQITPDNRLVLDLSVTQDRRGETVKTGTGEAVSIDTQRI 513 Query: 602 KTKVQVEDGGTVVIGGIYTQTDNEHETRVPLLGEIPLLGALFRSRNKVRDKTELLIFLTP 661 T+V V +G TVV+GGI+ + N +VPLLG++P+LGALFR + K+ELLIF+TP Sbjct: 514 GTQVLVNNGETVVLGGIFQHSINNSVDKVPLLGDLPVLGALFRRTYEQMGKSELLIFVTP 573 Query: 662 RIV 664 ++V Sbjct: 574 KVV 576