BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0039.0090.p (362 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value YPO2237 [GEPR] COG0477 Permeases of the major facilitator superf... 269 7e-72 RSc2352 [GEPR] COG0477 Permeases of the major facilitator superf... 261 1e-69 BMEII1096 [GEPR] COG0477 Permeases of the major facilitator supe... 253 5e-67 PA2214 [GEPR] COG0477 Permeases of the major facilitator superfa... 212 1e-54 CC2354 [GEPR] COG0477 Permeases of the major facilitator superfa... 205 1e-52 >YPO2237 [GEPR] COG0477 Permeases of the major facilitator superfamily Ype Yersinia pestis Length = 436 Score = 269 bits (688), Expect = 7e-72, Method: Compositional matrix adjust. Identities = 144/349 (41%), Positives = 216/349 (61%), Gaps = 11/349 (3%) Query: 1 VGAKIWIARIMITWGMISSLMAF-TAPIAQWLGVSNETVFYTLRFLLGASEAGFFPGVIL 59 VGA++WIARIMITWG+IS+ MAF T P++ FY +RFLLG +EAGFFPG+IL Sbjct: 90 VGARLWIARIMITWGIISACMAFVTTPMS----------FYVMRFLLGVAEAGFFPGIIL 139 Query: 60 YMTYWYPAAMHSRVMAVVLLGNPFSYILGGPISGALMQFMGSGDSLAGWQWMFVIEALPA 119 Y++YW+P+ RV + ++ P S I+G P+SG +MQ+ AGWQWMF++E +P+ Sbjct: 140 YISYWFPSHRRGRVYGLFVISVPLSGIIGAPLSGWIMQYFNGFQGYAGWQWMFILEGIPS 199 Query: 120 CLLGIVILFVLSNDIASAKWLAPEEKAELARRLAAENKEKVNVPLKSLYALPILWFLALV 179 L+GI+I++ L + I A WL +EK L + E + L+ + P +W L L+ Sbjct: 200 VLVGILIIYKLKDRITHATWLTDKEKDILQTNIENEAAHYAHSRLRDAFLQPRVWLLTLI 259 Query: 180 YLLMMIGSYGINFWAPTIIRDAGVKSVLDIGMISAIPYILGATAMVFITRHAEKAGKHRS 239 Y ++ G Y I FW PT+IRD+GVK +L IG ++AIP A M+ ++R A++ + R Sbjct: 260 YFCLISGFYTIGFWLPTLIRDSGVKDILSIGFLTAIPSAAAAVTMIVVSRSADRLRERRW 319 Query: 240 YSVAVSMVAGLALVLCTLFPHNIYITLAGIAIAVGGSLTSIALFWGFPGAYFTGATAAAG 299 + +++ + ++L T F NI + + + I G+L++I LFW P A+ G+ AAAG Sbjct: 320 HLALTAVLGAVGIILSTYFSDNIVVAMVCLTIGAMGALSTIPLFWSLPTAFLGGSAAAAG 379 Query: 300 IAIINSVGNLGGFVGPYLLGALTTAFGSPRYGLMMLGGALFLAGVLIAL 348 IA INS GNLGGFV PY++G L S G++++ LF+ L+ L Sbjct: 380 IAFINSWGNLGGFVAPYMMGYLKDLTQSTTTGMLIISTTLFIGAALVFL 428 >RSc2352 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 442 Score = 261 bits (668), Expect = 1e-69, Method: Compositional matrix adjust. Identities = 146/346 (42%), Positives = 218/346 (63%), Gaps = 11/346 (3%) Query: 1 VGAKIWIARIMITWGMISSLMAFTAPIAQWLGVSNETVFYTLRFLLGASEAGFFPGVILY 60 VGA++WIARIMI+WG+IS+ M F V+ +FY +RFLLG +EAGFFPG+ILY Sbjct: 96 VGARMWIARIMISWGLISAAMMF---------VTTPAMFYVMRFLLGLAEAGFFPGIILY 146 Query: 61 MTYWYPAAMHSRVMAVVLLGNPFSYILGGPISGALMQFMGSGDSLAGWQWMFVIEALPAC 120 +TYWYPA R + S ++GGPISG ++ G LAGWQWMF+IE +P+ Sbjct: 147 LTYWYPAERRGRTTTFFMTAVALSGVIGGPISGWALKTFGGVYGLAGWQWMFLIEGIPSV 206 Query: 121 LLGIVILFVLSNDIASAKWLAPEEKAELARRLAAENKEKVNVPLKSLYALPILWFLALVY 180 ++G+ +L L N I+ A+WL EEKA L R +AAE +K + P+ ++ A P +W ++L+Y Sbjct: 207 VIGLCVLAYLDNRISHARWLTDEEKALLTRNIAAEEAQKEDAPIAAIMASPRVWLMSLIY 266 Query: 181 LLMMIGSYGINFWAPTIIRDAGVKSVLDIGMISAIPYILGATAMVFITRHAEKAGKHRSY 240 ++G YG++FW PT+I+ GV L +G+++AIPY AMV + R A++ + R + Sbjct: 267 FSFVMGLYGVSFWLPTLIKQTGVADPLSVGLLTAIPYGAAVVAMVLVARSADRT-RERRW 325 Query: 241 SVAVSMVAG-LALVLCTLFPHNIYITLAGIAIAVGGSLTSIALFWGFPGAYFTGATAAAG 299 +A+ +AG + LVL ++ N + +A + + G LT++ LFW P A+ G AAAG Sbjct: 326 HIAIPALAGAIGLVLSAVWHTNTTLAMAALTLGTMGILTTLPLFWSLPTAFLAGTGAAAG 385 Query: 300 IAIINSVGNLGGFVGPYLLGALTTAFGSPRYGLMMLGGALFLAGVL 345 IA+INS+GNL GF+ PY +G L S G+ +L ++ L +L Sbjct: 386 IALINSLGNLAGFLSPYAVGWLKDTTRSTDSGMYLLAASMVLGALL 431 >BMEII1096 [GEPR] COG0477 Permeases of the major facilitator superfamily Bme Brucella melitensis Length = 451 Score = 253 bits (646), Expect = 5e-67, Method: Compositional matrix adjust. Identities = 147/347 (42%), Positives = 214/347 (61%), Gaps = 11/347 (3%) Query: 1 VGAKIWIARIMITWGMISSLMAFTAPIAQWLGVSNETVFYTLRFLLGASEAGFFPGVILY 60 +GA++WIARIMITWG++S+L AF V E FY LRFLLGA+EAGF+PGVILY Sbjct: 105 LGARLWIARIMITWGLLSALFAF---------VQTEWQFYILRFLLGAAEAGFYPGVILY 155 Query: 61 MTYWYPAAMHSRVMAVVLLGNPFSYILGGPISGALMQFMGSGDSLAGWQWMFVIEALPAC 120 +TYW+P+ + A+ G+P + I G P+SG +M GWQWMFV+EA+PA Sbjct: 156 LTYWFPSHRRGNMFALFQAGSPAAGIFGNPLSGWIMDQFHDTAGWQGWQWMFVLEAIPAV 215 Query: 121 LLGIVILFVLSNDIASAKWLAPEEKAELARRLAAENKEK-VNVPLKSLYALPILWFLALV 179 +LG+VIL L N + +AKWL EEKA ++R + A++K K + L SL P+LW + L+ Sbjct: 216 VLGVVILLYLDNSVKAAKWLTEEEKAIISRDIEADSKGKAASHSLMSLVKNPMLWVMMLI 275 Query: 180 YLLMMIGSYGINFWAPTIIRDAGVKSVLDIGMISAIPYILGATAMVFITRHAEKAGKHRS 239 Y ++G +G+ W PT+IR +GV S + IG++ AIP+I AMV +R A+ + R Sbjct: 276 YFCFVMGQHGLTLWMPTLIRASGVTSNVTIGLLGAIPFICAIIAMVIFSRSADHYRERRW 335 Query: 240 YSVAVSMVAGLALVLCTLFPHNIYITLAGIAIAVGGSLTSIALFWGFPGAYFTGATAAAG 299 + V +++ + V+ N +++ +++A G L LFW P A +GA AAAG Sbjct: 336 HLVVPALLGAVGFVVAAS-ATNTTVSIIFLSMAAAGVLACAPLFWSLPTAILSGAAAAAG 394 Query: 300 IAIINSVGNLGGFVGPYLLGALTTAFGSPRYGLMMLGGALFLAGVLI 346 IA+INSV NL GF+ PY++G + A S G+ +L G L L ++ Sbjct: 395 IALINSVANLAGFISPYMVGIIRDATHSSELGMYVLAGFLILGAAIV 441 >PA2214 [GEPR] COG0477 Permeases of the major facilitator superfamily Pae Pseudomonas aeruginosa Length = 440 Score = 212 bits (540), Expect = 1e-54, Method: Compositional matrix adjust. Identities = 134/352 (38%), Positives = 201/352 (57%), Gaps = 17/352 (4%) Query: 1 VGAKIWIARIMITWGMISSLMAFTAPIAQWLGVSNETVFYTLRFLLGASEAGFFPGVILY 60 +GA++W+ RIM+TWG++S+ M F + FY LRFLLG +EAGFFPG+ILY Sbjct: 83 LGARVWLCRIMVTWGLVSAAMMFA---------DDAMTFYVLRFLLGVAEAGFFPGIILY 133 Query: 61 MTYWYPAAMHSRVMAVVLLGNPFSYILGGPISGALMQFMGSGDSLAGWQWMFVIEALPAC 120 +TYW+P ++ + + G P + +LGGP+SG L++F G LA WQW+FV E L A Sbjct: 134 LTYWFPQRSRAQALGLFYFGLPLALVLGGPLSGWLLEFHGI-FGLANWQWLFVTEGLLAS 192 Query: 121 LLGIVILFVLSNDIASAKWLAPEEKAELARRLAAEN-KEKVNVP---LKSLYALPILWFL 176 L+GI F L + A WL+ E+K L LA E+ +++ P L +L + +L F Sbjct: 193 LVGIAAYFYLVDRPRDAGWLSDEQKRALEGELAEEDTRKQARGPHGFLSALRSGQVLKF- 251 Query: 177 ALVYLLMMIGSYGINFWAPTIIRDAGVKSV-LDIGMISAIPYILGATAMVFITRHAEKAG 235 LVY + + YG+ F+ PT I V L++G+I+AIP++ +TR A+++G Sbjct: 252 CLVYFTIQMSVYGVVFYLPTRIASFLDGQVGLNVGLITAIPWVCALVVTRLVTRQADRSG 311 Query: 236 KHRSYSVAVSMVAGLALVLCTLFPHNIYITLAGIAIAVGGSLTSIALFWGFPGAYFTGAT 295 +HR +VA+ + A + + N+ + + A G ++ LFW P Y +GA Sbjct: 312 QHRQLAVAM-LGMAAAGIAASALAGNLGLAVIAFCFAASGFVSVQPLFWTLPTGYLSGAA 370 Query: 296 AAAGIAIINSVGNLGGFVGPYLLGALTTAFGSPRYGLMMLGGALFLAGVLIA 347 AA+GIA+INS+GNLGGFV P L + + F PR G+ L L L+A Sbjct: 371 AASGIALINSLGNLGGFVAPNLKTLMESQFADPRAGMFALAAVGLLGACLLA 422 >CC2354 [GEPR] COG0477 Permeases of the major facilitator superfamily Ccr Caulobacter vibrioides Length = 430 Score = 205 bits (522), Expect = 1e-52, Method: Compositional matrix adjust. Identities = 131/361 (36%), Positives = 205/361 (56%), Gaps = 17/361 (4%) Query: 1 VGAKIWIARIMITWGMISSLMAFTAPIAQWLGVSNETVFYTLRFLLGASEAGFFPGVILY 60 VGA++W ARIM +WG+++ + FT N +FY LRFLLG +EAGFFPGV+ Sbjct: 81 VGARVWFARIMFSWGLVTLALGFT---------QNAAMFYVLRFLLGVAEAGFFPGVLYV 131 Query: 61 MTYWYPAAMHSRVMAVVLLGNPFSYILGGPISGALMQFMGSGDSLAGWQWMFVIEALPAC 120 +T WYP A +R++ + ++ + F+ +G I G L+ M LAGWQW+F++ PA Sbjct: 132 LTLWYPQAHRARMVGLFMIASAFANAVGAAIGGLLLG-MDGFLGLAGWQWVFLVTGAPAV 190 Query: 121 LLGIVILFVLSNDIASAKWLAPEEKAELARRLAAENKEKVNVPLKSLYAL--PILWFLAL 178 LL +L+ L + + A+WL EK+ LA LAAE +V+ + A+ P + LA Sbjct: 191 LLAPYVLWRLPSGPSDARWLPDVEKSWLASTLAAERGGEVDDHRGAWKAIFDPRVLMLAG 250 Query: 179 VYLLMMIGSYGINFWAPTIIRDAGVKSVLDIGMISAIPYILGATAMVFITRHAEKAGKHR 238 +Y+ M + +YG+++W PTI++ GV + ++ G I+ IP++L A A+ F+ RHA + G Sbjct: 251 LYIGMPLSAYGLSYWLPTIVKSFGVSNTVN-GFINVIPWLLVAVALWFVPRHAARHGASA 309 Query: 239 SYSVAVSMVAGLALVLCTLFPHNIYITLAGIAIAVGGSLTSIALFWGFPGAYFTGATAAA 298 + ++A +AL L + P + + IA + +FW P ++ +G AAA Sbjct: 310 WHIAGPVLLAAVALSLSVILP-GAALKFTMLCIAAPAIFAAQPVFWSLPPSFLSGPRAAA 368 Query: 299 GIAIINSVGNLGGFVGPYLLGALTTAFGSPRYGLMMLGGALFLAGVL--IALGG-RKRGP 355 GIA IN+VGNLGGF+ L+ + A GS ++ L L + +L I +G RK P Sbjct: 369 GIATINAVGNLGGFIAQNLVPVVRDATGSELAPMLALAAVLLVTSLLIFIVMGRLRKMSP 428 Query: 356 A 356 A Sbjct: 429 A 429