BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0039.0003.p (398 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc0421 [GEPR] COG0477 Permeases of the major facilitator superf... 385 e-106 NMA1673 [GEPR] COG0477 Permeases of the major facilitator superf... 332 6e-91 STM0436 [GEPR] COG0477 Permeases of the major facilitator superf... 317 2e-86 NMB1461 [GEPR] COG0477 Permeases of the major facilitator superf... 315 1e-85 yajR [GEPR] COG0477 Permeases of the major facilitator superfami... 313 5e-85 >RSc0421 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 387 Score = 385 bits (988), Expect = e-106, Method: Compositional matrix adjust. Identities = 218/385 (56%), Positives = 278/385 (72%), Gaps = 6/385 (1%) Query: 1 MSRAEVRASASLASIFSLRMLGLFLVLPVFAVHAHSLPGGDNDTLVGIALGIYGLAQAFG 60 M+ E+RA+ SLA IF+LRMLGLF+++PVFAV A SLP G N LV A+G+YGL QA Sbjct: 1 MTGFELRAATSLAGIFALRMLGLFMIMPVFAVFAKSLPDGGNTQLVAFAIGVYGLTQAVL 60 Query: 61 QIPYGIASDRYGRKRIIVIGLLLFALGSFVAAAATSVNWLLVGRALQGSGAISAAITAFI 120 IPYG SDR+GRK +IV GLL+FA GS VAA + SV + VGRA+QG+GAIS+A+ AF+ Sbjct: 61 YIPYGWLSDRFGRKPVIVAGLLIFAAGSLVAAFSHSVAGIAVGRAIQGAGAISSAVIAFV 120 Query: 121 ADSTREEHRTKAMAMVGASIGVTFAVSMVASPLLYKSIGMGGIFGLTGVLSLIAIAVVVW 180 AD TREEHRTKAMAM+G SIGV+FAV++V++P++++ IGM G+F G+L+LIAI VV+W Sbjct: 121 ADLTREEHRTKAMAMIGGSIGVSFAVAIVSAPVIFRWIGMPGMFLAIGILALIAIGVVLW 180 Query: 181 VVPAAPLVQAR-RVPLREVLRHGELMRLNFGVFTLHLTQVAMFMVVPGALVQLAGLPLGE 239 VVP AP A P REVL + EL+RLNFGVF LH TQ A+F+V+P +++ AGLP+ Sbjct: 181 VVPDAPRPAAHVSAPFREVLHNRELLRLNFGVFALHATQTALFVVLPH-MLETAGLPVDS 239 Query: 240 HWKIYLPVVLASFVLMLPPVFVAEKYGRMKQVFLGAIGLMLLVQLGFWAVLSHPLGHWWM 299 HWKIYLPV+ SFVLM+P + AEK G+MK V L A+ L+++ QL L Sbjct: 240 HWKIYLPVMGVSFVLMVPAIIAAEKRGKMKAVLLSAVALVMVAQLA----LGEAQPTLAS 295 Query: 300 LVALLFLFFVAFNILEASQPSLVSRIAPPAAKGAALGVYNTLQALGLSCGGALGGWIKQN 359 L L ++F+ FN+LEASQPSLVS+ AP KGAA+GVYNT QALGL GGA GGWI + Sbjct: 296 LTVALLVYFLGFNVLEASQPSLVSKYAPGVRKGAAMGVYNTTQALGLFTGGAGGGWILLH 355 Query: 360 VGISEVFALSAVVTLTWLIIAANMK 384 G VF A + WLIIA+ M+ Sbjct: 356 AGQHAVFFTCAGLAAAWLIIASPMR 380 >NMA1673 [GEPR] COG0477 Permeases of the major facilitator superfamily NmA Neisseria meningitidis Z2491 Length = 461 Score = 332 bits (852), Expect = 6e-91, Method: Compositional matrix adjust. Identities = 186/383 (48%), Positives = 271/383 (70%), Gaps = 12/383 (3%) Query: 5 EVRASASLASIFSLRMLGLFLVLPVFAVHAHSLPGGD-NDTLVGIALGIYGLAQAFGQIP 63 E RAS +L+ +++LRMLG+FLVLPV AV+A SLPG + N TLVG+A+GIYGL QA Q+P Sbjct: 14 EWRASTTLSGVYALRMLGMFLVLPVLAVYAASLPGAEGNKTLVGLAMGIYGLTQALLQLP 73 Query: 64 YGIASDRYGRKRIIVIGLLLFALGSFVAAAATSVNWLLVGRALQGSGAISAAITAFIADS 123 GIASD++GRK+ I +GL++FA GSF+AAAA ++ L+ RA+QG+GA+SAA+TA +AD Sbjct: 74 LGIASDKFGRKKTIYVGLIVFAAGSFLAAAADTLPMLVAARAIQGAGAVSAAVTALLADL 133 Query: 124 TREEHRTKAMAMVGASIGVTFAVSMVASPLLYKSIGMGGIFGLTGVLSLIAIAVVVWVVP 183 TR+ RT+AMAM+G SIG+TF+VS+V +P++ ++G+ G+F LTG+L++ +I VV W+ P Sbjct: 134 TRDGVRTRAMAMIGLSIGLTFSVSLVVAPVIADAVGVRGLFLLTGILTVASIGVVAWMTP 193 Query: 184 AAPL------VQARRVPLREVLRHGELMRLNFGVFTLHLTQVAMFMVVPGALVQLAGLPL 237 + QA+ + EVL++ L+ L+FG+F LH Q+A+F +P A+ QL GL Sbjct: 194 DPEVSKLHEDTQAQPSRIGEVLKNRRLLTLDFGIFALHAAQMALFTALPFAMTQL-GLEK 252 Query: 238 GEHWKIYLPVVLASFVLMLPPVFVAEKYGRMKQVFLGAIGLMLLVQLGFWAVLSHPLGHW 297 +HWK+YLP + V+M+P + V E ++KQVF+ I + QLG + + +G Sbjct: 253 IQHWKVYLPSTITGLVVMVPLIIVGETRNKLKQVFILGIACIAAAQLGLLSGM-RSVG-- 309 Query: 298 WMLVALLFLFFVAFNILEASQPSLVSRIAPPAAKGAALGVYNTLQALGLSCGGALGGWIK 357 ++ A L ++F+ FN+LEAS PS+VS+IAP KG A+GVYNT+Q+LGL GG GG + Sbjct: 310 -LITAYLVVYFIGFNVLEASLPSMVSKIAPSDLKGTAMGVYNTMQSLGLFAGGVAGGLLF 368 Query: 358 QNVGISEVFALSAVVTLTWLIIA 380 Q G S VFA +++ L WL+IA Sbjct: 369 QKYGFSGVFAFCSILMLLWLVIA 391 >STM0436 [GEPR] COG0477 Permeases of the major facilitator superfamily Sty Salmonella typhimurium LT2 Length = 449 Score = 317 bits (813), Expect = 2e-86, Method: Compositional matrix adjust. Identities = 174/397 (43%), Positives = 258/397 (64%), Gaps = 12/397 (3%) Query: 1 MSRAEVRASASLASIFSLRMLGLFLVLPVFAVHAHSLPGGDNDTLVGIALGIYGLAQAFG 60 M+ E+RA+ L ++FSLRMLG+F+VLPV + +L G ++ L+GIA+GIYGLAQA Sbjct: 1 MTPGELRATWGLGTVFSLRMLGMFMVLPVLTTYGMALQGA-SEALIGIAIGIYGLAQAIF 59 Query: 61 QIPYGIASDRYGRKRIIVIGLLLFALGSFVAAAATSVNWLLVGRALQGSGAISAAITAFI 120 QIP+G+ SDR GRK +IV GL +F GS +AA + S+ +++GRALQGSGAI+AA+ A + Sbjct: 60 QIPFGLLSDRIGRKPLIVGGLAVFVAGSVIAALSHSIWGIILGRALQGSGAIAAAVMALL 119 Query: 121 ADSTREEHRTKAMAMVGASIGVTFAVSMVASPLLYKSIGMGGIFGLTGVLSLIAIAVVVW 180 +D TRE++RTKAMA +G S G+TFA++MV P++ S+G+ +F + L+ + I + +W Sbjct: 120 SDLTREQNRTKAMAFIGVSFGITFAIAMVLGPIVTHSLGLNALFWMIAALATLGILLTIW 179 Query: 181 VVPAAPLVQARRV------PLREVLRHGELMRLNFGVFTLHLTQVAMFMVVPGALVQLAG 234 VVP + R +VL L++LNFG+ LH+ ++ F+ +PG L AG Sbjct: 180 VVPNSTNHVLNRESGMVKGSFSKVLAEPRLLKLNFGIMCLHILLMSTFVALPGQLAD-AG 238 Query: 235 LPLGEHWKIYLPVVLASFVLMLPPVFVAEKYGRMKQVFLGAIGLMLLVQLGFWAVLSHPL 294 P EHWK+YL ++ +F ++P + AE RMKQVFL +GL+++ ++ W Sbjct: 239 FPAAEHWKVYLATMVIAFAAVVPFIIYAEVKRRMKQVFLFCVGLIVVAEIVLWGAGQ--- 295 Query: 295 GHWWMLVALLFLFFVAFNILEASQPSLVSRIAPPAAKGAALGVYNTLQALGLSCGGALGG 354 H+W LV + LFF+AFN++EA PSL+S+ +P KG A+GVY+T Q LG++ GG+LGG Sbjct: 296 -HFWELVIGVQLFFLAFNLMEALLPSLISKESPAGYKGTAMGVYSTSQFLGVALGGSLGG 354 Query: 355 WIKQNVGISEVFALSAVVTLTWLIIAANMKNLPRRSA 391 WI VF AV+ + WL +A+ MK P S+ Sbjct: 355 WIDGTFDGQTVFLAGAVLAMVWLAVASTMKEPPYVSS 391 >NMB1461 [GEPR] COG0477 Permeases of the major facilitator superfamily Nme Neisseria meningitidis MC58 Length = 461 Score = 315 bits (807), Expect = 1e-85, Method: Compositional matrix adjust. Identities = 188/383 (49%), Positives = 272/383 (71%), Gaps = 12/383 (3%) Query: 5 EVRASASLASIFSLRMLGLFLVLPVFAVHAHSLPGGD-NDTLVGIALGIYGLAQAFGQIP 63 E RAS +L+ +++LRMLG+FLVLPV AV+A SLPG + N TLVG+A+GIYGL QA Q+P Sbjct: 14 EWRASTTLSGVYALRMLGMFLVLPVLAVYAASLPGAEGNKTLVGLAMGIYGLTQALLQLP 73 Query: 64 YGIASDRYGRKRIIVIGLLLFALGSFVAAAATSVNWLLVGRALQGSGAISAAITAFIADS 123 GIASD++GRK+ I GL++FA GSF+AAAA ++ L+ RA+QG+GA+SAA+TA +AD Sbjct: 74 LGIASDKFGRKKTIYAGLVVFAAGSFLAAAADTLPMLVAARAIQGAGAVSAAVTALLADL 133 Query: 124 TREEHRTKAMAMVGASIGVTFAVSMVASPLLYKSIGMGGIFGLTGVLSLIAIAVVVWVVP 183 TR+ RT+AMAM+G SIG+TF+VS+V +P++ ++G+ G+F LTG+L++I+I VV W+ P Sbjct: 134 TRDGVRTRAMAMIGLSIGLTFSVSLVVAPVIADAVGVRGLFMLTGILTVISIGVVAWMTP 193 Query: 184 AAPL------VQARRVPLREVLRHGELMRLNFGVFTLHLTQVAMFMVVPGALVQLAGLPL 237 + QA+ + EVL++ L+ L+FG+F LH Q+A+F +P A+ QL GL Sbjct: 194 DPEVSKLHEDTQAQPSRIGEVLKNRRLLTLDFGIFALHAAQMALFTALPFAMTQL-GLEK 252 Query: 238 GEHWKIYLPVVLASFVLMLPPVFVAEKYGRMKQVFLGAIGLMLLVQLGFWAVLSHPLGHW 297 +HWK+YLP + V+M+P + V E ++KQVF+ I + QLG + + +G Sbjct: 253 IQHWKVYLPSTITGLVVMVPLIIVGETRNKLKQVFVLGIVCIAAAQLGLLSGM-RSVG-- 309 Query: 298 WMLVALLFLFFVAFNILEASQPSLVSRIAPPAAKGAALGVYNTLQALGLSCGGALGGWIK 357 ++ A L ++F+ FN+LEAS PS+VS+IAP KG A+GVYNT+Q+LGL GGA GG + Sbjct: 310 -LITAYLVVYFIGFNVLEASLPSMVSKIAPSDLKGTAMGVYNTMQSLGLFAGGAAGGLLF 368 Query: 358 QNVGISEVFALSAVVTLTWLIIA 380 Q G S VFA +++ L WL+IA Sbjct: 369 QKYGFSGVFAFCSILMLLWLVIA 391 >yajR [GEPR] COG0477 Permeases of the major facilitator superfamily Eco Escherichia coli K12 Length = 456 Score = 313 bits (801), Expect = 5e-85, Method: Compositional matrix adjust. Identities = 172/397 (43%), Positives = 256/397 (64%), Gaps = 12/397 (3%) Query: 1 MSRAEVRASASLASIFSLRMLGLFLVLPVFAVHAHSLPGGDNDTLVGIALGIYGLAQAFG 60 M+ E RA+ L ++FSLRMLG+F+VLPV + +L G ++ L+GIA+GIYGL QA Sbjct: 8 MTPGERRATWGLGTVFSLRMLGMFMVLPVLTTYGMALQGA-SEALIGIAIGIYGLTQAVF 66 Query: 61 QIPYGIASDRYGRKRIIVIGLLLFALGSFVAAAATSVNWLLVGRALQGSGAISAAITAFI 120 QIP+G+ SDR GRK +IV GL +FA GS +AA + S+ +++GRALQGSGAI+AA+ A + Sbjct: 67 QIPFGLLSDRIGRKPLIVGGLAVFAAGSVIAALSDSIWGIILGRALQGSGAIAAAVMALL 126 Query: 121 ADSTREEHRTKAMAMVGASIGVTFAVSMVASPLLYKSIGMGGIFGLTGVLSLIAIAVVVW 180 +D TRE++RTKAMA +G S G+TFA++MV P++ +G+ +F + +L+ IA+ +W Sbjct: 127 SDLTREQNRTKAMAFIGVSFGITFAIAMVLGPIITHKLGLHALFWMIAILATTGIALTIW 186 Query: 181 VVPAAPLVQARRV------PLREVLRHGELMRLNFGVFTLHLTQVAMFMVVPGALVQLAG 234 VVP + R +VL L++LNFG+ LH+ ++ F+ +PG L AG Sbjct: 187 VVPNSSTHVLNRESGMVKGSFSKVLAEPRLLKLNFGIMCLHILLMSTFVALPGQLAD-AG 245 Query: 235 LPLGEHWKIYLPVVLASFVLMLPPVFVAEKYGRMKQVFLGAIGLMLLVQLGFWAVLSHPL 294 P EHWK+YL +L +F ++P + AE +MKQVF+ +GL+++ ++ W + Sbjct: 246 FPAAEHWKVYLATMLIAFGSVVPFIIYAEVKRKMKQVFVFCVGLIVVAEIVLWNAQT--- 302 Query: 295 GHWWMLVALLFLFFVAFNILEASQPSLVSRIAPPAAKGAALGVYNTLQALGLSCGGALGG 354 +W LV + LFFVAFN++EA PSL+S+ +P KG A+GVY+T Q LG++ GG+LGG Sbjct: 303 -QFWQLVVGVQLFFVAFNLMEALLPSLISKESPAGYKGTAMGVYSTSQFLGVAIGGSLGG 361 Query: 355 WIKQNVGISEVFALSAVVTLTWLIIAANMKNLPRRSA 391 WI VF A++ WL +A+ MK P S+ Sbjct: 362 WINGMFDGQGVFLAGAMLAAVWLTVASTMKEPPYVSS 398