BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0035.0072.p (492 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value YPO2916 [T] COG0642 Signal transduction histidine kinase Ype Yer... 203 8e-52 ZyfhK [T] COG0642 Signal transduction histidine kinase EcZ Esche... 199 9e-51 ECs3422 [T] COG0642 Signal transduction histidine kinase Ecs Esc... 199 9e-51 yfhK [T] COG0642 Signal transduction histidine kinase Eco Escher... 199 1e-50 STM2564 [T] COG0642 Signal transduction histidine kinase Sty Sal... 192 2e-48 >YPO2916 [T] COG0642 Signal transduction histidine kinase Ype Yersinia pestis Length = 483 Score = 203 bits (516), Expect = 8e-52, Method: Compositional matrix adjust. Identities = 155/467 (33%), Positives = 238/467 (50%), Gaps = 9/467 (1%) Query: 25 SFRQLLLAAFLLIAALLSGTSIHALFTLDRMSANSRETARQAVQLTEAAQRLAERTVAME 84 S RQL+L AFLL+ L + A +LD +S + + R + ++ + + ME Sbjct: 18 SLRQLVLMAFLLVLLPLLVLAYQAYQSLDHLSTQAADINRTTLADARRSEAMTSVALEME 77 Query: 85 RSARQYLVLDDPAFHDRFNEARDQARQALGELADSLPKAPREMFGQWSVYVDEAAGVLDA 144 RS RQY VLDD + R Q Q L A LP A + +++ + Sbjct: 78 RSYRQYCVLDDATLATLYQHQRKQYTQMLVAHAPILPDA--RYYQTLQGLLNQLTDIKCK 135 Query: 145 DSRKDKGEQARLFQDFARLPALNERIALESRREVDRRNNALSAALEQQRQMLTAQVVGAI 204 +S DK E + L + F+R N + +R + R L + ++ Q Q + Sbjct: 136 NSGPDK-EASILLEQFSRS---NAEMVQATRDVIFSRGQQLQKDIAERGQFFGWQSLLLF 191 Query: 205 VLAVLLAFCFGLWLSRPMARLEQAIGRLGDNR-FDQPIDVRGPADIRRLGQQLDWLRQRL 263 +++VLL F + P+ +E+ I RLG+ R +GP ++R L Q++ WL +RL Sbjct: 192 LVSVLLVVLFTRMIIGPVKGIERMINRLGEGRSLGNTALFKGPRELRSLAQRIIWLSERL 251 Query: 264 ADLEAEKSRFLRHVSHELKTPLAALCEGAALLDDGVAGQLTDSQREIARILRQNTQSLQT 323 A LE+++ FLRH+SHELKTPLA++ EG LL D VAG LT Q+E+ IL +++ LQ Sbjct: 252 AWLESQRHEFLRHISHELKTPLASMREGTELLADEVAGPLTQDQQEVVAILDHSSRHLQQ 311 Query: 324 QIEDLLRYNEVSFDAQRIHPVPVDLRALLHKVIDDQRLQWLARELKVEIEGAARTVVVDP 383 IE LL YN D P VDL ++ VI L A+ ++ E E AR +P Sbjct: 312 LIEQLLDYNRKLADGPG-EPEHVDLAEMVGNVISAHSLPARAKMIRTETELDARICWAEP 370 Query: 384 EKMAIVLANLLSNAVRFSPQGGFIRFLLSEAPGLVRVECVDQGPGVAPTDAARIFEPFYQ 443 + VL NL SNAV + + G I + V+++ + G + ++ IFEPF+Q Sbjct: 371 TLLMRVLDNLYSNAVHYGEESGTIWICSRQVNDRVQIDVANTGAPIPTSEEIMIFEPFFQ 430 Query: 444 GLNQPTAARRGNGIGLSVVREYVQAHSGKVYLVPREGGA-HFRIELP 489 G +Q A +G+G+GLS+ ++ ++ G + LV + A FRIELP Sbjct: 431 GSHQRKGAVKGSGLGLSIAQDCIRRMQGDLQLVTVDYAAVCFRIELP 477 >ZyfhK [T] COG0642 Signal transduction histidine kinase EcZ Escherichia coli O157:H7 EDL933 Length = 496 Score = 199 bits (507), Expect = 9e-51, Method: Compositional matrix adjust. Identities = 145/470 (30%), Positives = 239/470 (50%), Gaps = 9/470 (1%) Query: 25 SFRQLLLAAFLLIAALLSGTSIHALFTLDRMSANSRETARQAVQLTEAAQRLAERTVAME 84 S RQL++ AFLLI L + A +L+ +S + R + ++ + + ME Sbjct: 31 SLRQLVMLAFLLILLPLLVLAWQAWQSLNALSDQAALVNRTTLIDARRSEAMTNAALEME 90 Query: 85 RSARQYLVLDDPAFHDRFNEARDQARQALGELADSLPKAPREMFGQWSVYVDEAAGVLDA 144 RS RQY VLDDP + R + + L A LP +++ ++ A + Sbjct: 91 RSYRQYCVLDDPTLAKVYQSQRKRYSEMLDAHAGVLPDD--KLYQALRQDLNNLAQLQCN 148 Query: 145 DSRKDKGEQARLFQDFARLPALNERIALESRREVDRRNNALSAALEQQRQMLTAQVVGAI 204 +S G A + N + +R V R L + ++ Q Q + Sbjct: 149 NS----GPDAAAAARLEAFASANTEMVQATRTVVFSRGQQLQREIAERGQYFGWQSLVLF 204 Query: 205 VLAVLLAFCFGLWLSRPMARLEQAIGRLGDNR-FDQPIDVRGPADIRRLGQQLDWLRQRL 263 ++++++ F + P+ +E+ I RLG+ R + GP+++R +GQ++ WL +RL Sbjct: 205 LVSLVMVLLFTRMIIGPVKNIERMINRLGEGRSLGNSVSFSGPSELRSVGQRILWLSERL 264 Query: 264 ADLEAEKSRFLRHVSHELKTPLAALCEGAALLDDGVAGQLTDSQREIARILRQNTQSLQT 323 + LE+++ +FLRH+SHELKTPLA++ EG LL D V G LT Q+E+ IL ++++LQ Sbjct: 265 SWLESQRHQFLRHLSHELKTPLASMREGTELLADQVVGPLTPEQKEVVSILDSSSRNLQK 324 Query: 324 QIEDLLRYNEVSFDAQRIHPVPVDLRALLHKVIDDQRLQWLARELKVEIEGAARTVVVDP 383 IE LL YN D+ + V+L L+ V+ L A+ + +++ A + +P Sbjct: 325 LIEQLLDYNRKQADSA-VELDNVELAPLVETVVSAHSLPARAKMMHTDVDLKATACLAEP 383 Query: 384 EKMAIVLANLLSNAVRFSPQGGFIRFLLSEAPGLVRVECVDQGPGVAPTDAARIFEPFYQ 443 + VL NL SNAV + + G I S V ++ ++ G + + A IFEPF+Q Sbjct: 384 MLLMSVLDNLYSNAVHYGAESGNICLRSSLHGARVYIDVINTGTPIPQEERAMIFEPFFQ 443 Query: 444 GLNQPTAARRGNGIGLSVVREYVQAHSGKVYLVPREG-GAHFRIELPDEK 492 G +Q A +G+G+GLS+ R+ ++ G++YLV G FRIELP K Sbjct: 444 GSHQRKGAVKGSGLGLSIARDCIRRMQGELYLVDESGQDVCFRIELPSSK 493 >ECs3422 [T] COG0642 Signal transduction histidine kinase Ecs Escherichia coli O157:H7 Length = 496 Score = 199 bits (507), Expect = 9e-51, Method: Compositional matrix adjust. Identities = 145/470 (30%), Positives = 239/470 (50%), Gaps = 9/470 (1%) Query: 25 SFRQLLLAAFLLIAALLSGTSIHALFTLDRMSANSRETARQAVQLTEAAQRLAERTVAME 84 S RQL++ AFLLI L + A +L+ +S + R + ++ + + ME Sbjct: 31 SLRQLVMLAFLLILLPLLVLAWQAWQSLNALSDQAALVNRTTLIDARRSEAMTNAALEME 90 Query: 85 RSARQYLVLDDPAFHDRFNEARDQARQALGELADSLPKAPREMFGQWSVYVDEAAGVLDA 144 RS RQY VLDDP + R + + L A LP +++ ++ A + Sbjct: 91 RSYRQYCVLDDPTLAKVYQSQRKRYSEMLDAHAGVLPDD--KLYQALRQDLNNLAQLQCN 148 Query: 145 DSRKDKGEQARLFQDFARLPALNERIALESRREVDRRNNALSAALEQQRQMLTAQVVGAI 204 +S G A + N + +R V R L + ++ Q Q + Sbjct: 149 NS----GPDAAAAARLEAFASANTEMVQATRTVVFSRGQQLQREIAERGQYFGWQSLVLF 204 Query: 205 VLAVLLAFCFGLWLSRPMARLEQAIGRLGDNR-FDQPIDVRGPADIRRLGQQLDWLRQRL 263 ++++++ F + P+ +E+ I RLG+ R + GP+++R +GQ++ WL +RL Sbjct: 205 LVSLVMVLLFTRMIIGPVKNIERMINRLGEGRSLGNSVSFSGPSELRSVGQRILWLSERL 264 Query: 264 ADLEAEKSRFLRHVSHELKTPLAALCEGAALLDDGVAGQLTDSQREIARILRQNTQSLQT 323 + LE+++ +FLRH+SHELKTPLA++ EG LL D V G LT Q+E+ IL ++++LQ Sbjct: 265 SWLESQRHQFLRHLSHELKTPLASMREGTELLADQVVGPLTPEQKEVVSILDSSSRNLQK 324 Query: 324 QIEDLLRYNEVSFDAQRIHPVPVDLRALLHKVIDDQRLQWLARELKVEIEGAARTVVVDP 383 IE LL YN D+ + V+L L+ V+ L A+ + +++ A + +P Sbjct: 325 LIEQLLDYNRKQADSA-VELDNVELAPLVETVVSAHSLPARAKMMHTDVDLKATACLAEP 383 Query: 384 EKMAIVLANLLSNAVRFSPQGGFIRFLLSEAPGLVRVECVDQGPGVAPTDAARIFEPFYQ 443 + VL NL SNAV + + G I S V ++ ++ G + + A IFEPF+Q Sbjct: 384 MLLMSVLDNLYSNAVHYGAESGNICLRSSLHGARVYIDVINTGTPIPQEERAMIFEPFFQ 443 Query: 444 GLNQPTAARRGNGIGLSVVREYVQAHSGKVYLVPREG-GAHFRIELPDEK 492 G +Q A +G+G+GLS+ R+ ++ G++YLV G FRIELP K Sbjct: 444 GSHQRKGAVKGSGLGLSIARDCIRRMQGELYLVDESGQDVCFRIELPSSK 493 >yfhK [T] COG0642 Signal transduction histidine kinase Eco Escherichia coli K12 Length = 496 Score = 199 bits (506), Expect = 1e-50, Method: Compositional matrix adjust. Identities = 146/477 (30%), Positives = 235/477 (49%), Gaps = 23/477 (4%) Query: 25 SFRQLLLAAFLLIAALLSGTSIHALFTLDRMSANSRETARQAVQLTEAAQRLAERTVAME 84 S RQL++ AFLLI L + A +L+ +S + R + ++ + + ME Sbjct: 31 SLRQLVMLAFLLILLPLLVLAWQAWQSLNALSDQAALVNRTTLIDARRSEAMTNAALEME 90 Query: 85 RSARQYLVLDDPAFHDRFNEARDQARQALGELADSLPKAPREMFGQWSVYVDEAAGVLDA 144 RS RQY VLDDP + R + + L A LP D+ L Sbjct: 91 RSYRQYCVLDDPTLAKVYQSQRKRYSEMLDAHAGVLPD-------------DKLYQALRQ 137 Query: 145 DSRK-------DKGEQARLFQDFARLPALNERIALESRREVDRRNNALSAALEQQRQMLT 197 D + G A + N + +R V R L + ++ Q Sbjct: 138 DLHNLAQLQCNNSGPDAAAAARLEAFASANTEMVQATRTVVFSRGQQLQREIAERGQYFG 197 Query: 198 AQVVGAIVLAVLLAFCFGLWLSRPMARLEQAIGRLGDNR-FDQPIDVRGPADIRRLGQQL 256 Q + ++++++ F + P+ +E+ I RLG+ R + GP+++R +GQ++ Sbjct: 198 WQSLVLFLVSLVMVLLFTRMIIGPVKNIERMINRLGEGRSLGNSVSFSGPSELRSVGQRI 257 Query: 257 DWLRQRLADLEAEKSRFLRHVSHELKTPLAALCEGAALLDDGVAGQLTDSQREIARILRQ 316 WL +RL+ LE+++ +FLRH+SHELKTPLA++ EG LL D V G LT Q+E+ IL Sbjct: 258 LWLSERLSWLESQRHQFLRHLSHELKTPLASMREGTELLADQVVGPLTPEQKEVVSILDS 317 Query: 317 NTQSLQTQIEDLLRYNEVSFDAQRIHPVPVDLRALLHKVIDDQRLQWLARELKVEIEGAA 376 ++++LQ IE LL YN D+ + V+L L+ V+ L A+ + +++ A Sbjct: 318 SSRNLQKLIEQLLDYNRKQADSA-VELENVELAPLVETVVSAHSLPARAKMMHTDVDLKA 376 Query: 377 RTVVVDPEKMAIVLANLLSNAVRFSPQGGFIRFLLSEAPGLVRVECVDQGPGVAPTDAAR 436 + +P + VL NL SNAV + + G I S V ++ ++ G + + A Sbjct: 377 TACLAEPMLLMSVLDNLYSNAVHYGAESGNICLRSSLHGARVYIDVINTGTPIPQEERAM 436 Query: 437 IFEPFYQGLNQPTAARRGNGIGLSVVREYVQAHSGKVYLVPREG-GAHFRIELPDEK 492 IFEPF+QG +Q A +G+G+GLS+ R+ ++ G++YLV G FRIELP K Sbjct: 437 IFEPFFQGSHQRKGAVKGSGLGLSIARDCIRRMQGELYLVDESGQDVCFRIELPSSK 493 >STM2564 [T] COG0642 Signal transduction histidine kinase Sty Salmonella typhimurium LT2 Length = 480 Score = 192 bits (488), Expect = 2e-48, Method: Compositional matrix adjust. Identities = 145/469 (30%), Positives = 229/469 (48%), Gaps = 13/469 (2%) Query: 25 SFRQLLLAAFLLIAALLSGTSIHALFTLDRMSANSRETARQAVQLTEAAQRLAERTVAME 84 S RQL++ AFLLI L + A +L+ +S + T R + ++ + + ME Sbjct: 14 SLRQLVMLAFLLILLPLLVLAWQAWQSLNALSDQAAVTNRSTLIDARRSEAMTNVALEME 73 Query: 85 RSARQYLVLDDPAFHDRFNEARDQARQALGELADSLPKAPREMFGQWSVY--VDEAAGVL 142 RS RQY VLDDP + R + L A LP +Y + + L Sbjct: 74 RSYRQYCVLDDPTLAKVYQSQRKRYSDMLDAHAGVLPDD--------KLYQALRQDLNAL 125 Query: 143 DADSRKDKGEQARLFQDFARLPALNERIALESRREVDRRNNALSAALEQQRQMLTAQVVG 202 KD G +A N + +R V R L + ++ Q Q + Sbjct: 126 AQLQCKDSGPEAAAAARLEAFANANTEMVQATRTVVYSRGQQLQQEIAERGQFFGWQALV 185 Query: 203 AIVLAVLLAFCFGLWLSRPMARLEQAIGRLGDNR-FDQPIDVRGPADIRRLGQQLDWLRQ 261 ++++ + F + P+ +E+ I RLG+ R + GP ++R +GQ++ WL + Sbjct: 186 LFLVSLAMVLLFTRMIIGPVKGIERMINRLGEGRSLGNTVTFTGPRELRSVGQRIIWLSE 245 Query: 262 RLADLEAEKSRFLRHVSHELKTPLAALCEGAALLDDGVAGQLTDSQREIARILRQNTQSL 321 RLA LE+++ +FLRH+SHELKTPLA++ EG LL D V G LT Q+E+ IL ++++L Sbjct: 246 RLAWLESQRHQFLRHLSHELKTPLASMREGTELLADQVVGPLTPEQKEVVDILDDSSRNL 305 Query: 322 QTQIEDLLRYNEVSFDAQRIHPVPVDLRALLHKVIDDQRLQWLARELKVEIEGAARTVVV 381 Q IE LL YN D+ VD+ L+ V+ L A+ + +++ A + Sbjct: 306 QKLIEQLLDYNRKLVDSA-TELEAVDIAPLVDMVVSAHSLPARAKMMHTDVDLEAERCIA 364 Query: 382 DPEKMAIVLANLLSNAVRFSPQGGFIRFLLSEAPGLVRVECVDQGPGVAPTDAARIFEPF 441 +P + VL NL SNAV + + G I V ++ V+ G + T+ IFEPF Sbjct: 365 EPMLLMSVLDNLYSNAVHYGAESGNICIRSRSQGSTVYIDVVNSGEPIPQTEREMIFEPF 424 Query: 442 YQGLNQPTAARRGNGIGLSVVREYVQAHSGKVYLVPREGG-AHFRIELP 489 +QG +Q A +G+G+GLS+ R+ ++ G++ LV FRI LP Sbjct: 425 FQGSHQRKGAVKGSGLGLSIARDCIRRMQGEIQLVDDNAQEVCFRISLP 473