BLASTP 2.2.21 [Jun-14-2009]

Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Reference for compositional score matrix adjustment: Altschul, Stephen F., 
John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis,
Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches
using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.

Query= 0035.0066.p         (247 letters)

Database: COGmodified 
           192,987 sequences; 59,019,183 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

BH1646 [H] COG0302 GTP cyclohydrolase I Bha Bacillus halodurans       130   3e-30
HI1447 [H] COG0302 GTP cyclohydrolase I Hin Haemophilus influenzae    122   6e-28
lin2047 [H] COG0302 GTP cyclohydrolase I Lin Listeria innocua         122   7e-28
PM0693 [H] COG0302 GTP cyclohydrolase I Pmu Pasteurella multocida     120   3e-27
ML0223 [H] COG0302 GTP cyclohydrolase I Mle Mycobacterium leprae      119   8e-27

>BH1646 [H] COG0302 GTP cyclohydrolase I Bha Bacillus halodurans
          Length = 188

 Score =  130 bits (327), Expect = 3e-30,   Method: Compositional matrix adjust.
 Identities = 78/184 (42%), Positives = 104/184 (56%), Gaps = 7/184 (3%)

Query: 60  EVQGKLAAVLESLVIDVESDHNTQDTAKRVAKMYLNEVFKGRYQAAPPVTEFPNI--ERL 117
           ++Q  +  +LE++  D  +    +DT KRVAKMY  EVF G  Q   P   F  I  E  
Sbjct: 8   KIQQAVVMILEAIGED-PAREGLEDTPKRVAKMY-EEVFAGLNQ--DPKEHFATIFGEDH 63

Query: 118 NELMIVGPITVRSACSHHLCPIMGKVWVGVMPNEHSNLIGLSKYARLLEWVMSRPQIQEE 177
            EL++V  I   S C HHL P  GK  VG +P     + GLSK AR +E V  RPQ+QE 
Sbjct: 64  EELVLVKDIPFFSMCEHHLVPFFGKAHVGYIPK-GGKVTGLSKLARAVEAVARRPQLQER 122

Query: 178 AVSQAADLLMQKLQPDGLAIVMEADHFCMHWRGVKDMDSKMINSVMRGSFLRDANLRREF 237
             S  AD L++ L+P G+ +V+EA+H CM  RGVK   +  + S +RG+F  DA  R E 
Sbjct: 123 ITSTVADALVETLEPHGVIVVVEAEHMCMTMRGVKKPGAATVTSAVRGTFANDAAARAEV 182

Query: 238 LALI 241
           L+LI
Sbjct: 183 LSLI 186


>HI1447 [H] COG0302 GTP cyclohydrolase I Hin Haemophilus influenzae
          Length = 218

 Score =  122 bits (307), Expect = 6e-28,   Method: Compositional matrix adjust.
 Identities = 60/164 (36%), Positives = 95/164 (57%), Gaps = 3/164 (1%)

Query: 79  DHNTQDTAKRVAKMYLNEVFKG-RYQAAPPVTEFPNIERLNELMIVGPITVRSACSHHLC 137
           D + ++T  R+AKM+++E+F G  Y   P +T+  N  +++E++ V  IT+ S C HH  
Sbjct: 55  DDSLEETPNRLAKMFIDEIFSGMDYANFPKMTKIKNQMKVSEMVQVNDITLTSTCEHHFV 114

Query: 138 PIMGKVWVGVMPNEHSNLIGLSKYARLLEWVMSRPQIQEEAVSQAADLLMQKLQPDGLAI 197
            I GKV V   P +   +IGLSK  R++ +   RPQ+QE    Q        L+ D +A+
Sbjct: 115 TIDGKVCVAYYPKDW--VIGLSKINRIVSFFAQRPQVQERLTEQLLTAFQTILETDDVAV 172

Query: 198 VMEADHFCMHWRGVKDMDSKMINSVMRGSFLRDANLRREFLALI 241
            ++A HFC+  RG++D +S  + S   G FL D + R+EFLA +
Sbjct: 173 YVKATHFCVKARGIRDTNSYTVTSAYGGVFLEDRDTRKEFLATV 216


>lin2047 [H] COG0302 GTP cyclohydrolase I Lin Listeria innocua
          Length = 189

 Score =  122 bits (306), Expect = 7e-28,   Method: Compositional matrix adjust.
 Identities = 69/160 (43%), Positives = 94/160 (58%), Gaps = 6/160 (3%)

Query: 84  DTAKRVAKMYLNEVFKGRYQAAPPVTEFPNI--ERLNELMIVGPITVRSACSHHLCPIMG 141
           DT  RVA+MY  EVF G  +   P   F  I  E+  EL++V  I   S C HHL P  G
Sbjct: 31  DTPMRVARMY-EEVFAGLKK--DPSVHFDTIFEEQHEELVLVKDIRFSSMCEHHLVPFFG 87

Query: 142 KVWVGVMPNEHSNLIGLSKYARLLEWVMSRPQIQEEAVSQAADLLMQKLQPDGLAIVMEA 201
              V  +P ++  + GLSK AR+++ V  RPQ+QE   +  A+++M KL+P G+ ++MEA
Sbjct: 88  VAHVAYLP-QNGRVAGLSKLARVVDDVSRRPQLQERITTTVAEIMMDKLKPLGVMVIMEA 146

Query: 202 DHFCMHWRGVKDMDSKMINSVMRGSFLRDANLRREFLALI 241
           +H CM  RGV    +K I S +RG+F  D  LR E LALI
Sbjct: 147 EHMCMTIRGVNKPGTKTITSAVRGAFKNDDKLRSEVLALI 186


>PM0693 [H] COG0302 GTP cyclohydrolase I Pmu Pasteurella multocida
          Length = 218

 Score =  120 bits (301), Expect = 3e-27,   Method: Compositional matrix adjust.
 Identities = 63/187 (33%), Positives = 106/187 (56%), Gaps = 4/187 (2%)

Query: 58  QAEVQGKLAAVLESLVIDVESDHNTQDTAKRVAKMYLNEVFKG-RYQAAPPVTEFPNIER 116
           +A ++  +  V++ + +D+  D + ++T  R+AKM+++E+F G  Y   P +T   N  +
Sbjct: 35  RAGIEQHMREVMKLIGLDLRDD-SLEETPVRLAKMFVDEIFSGLDYANFPKITNIENRMK 93

Query: 117 LNELMIVGPITVRSACSHHLCPIMGKVWVGVMPNEHSNLIGLSKYARLLEWVMSRPQIQE 176
           ++E+++V  +T+ S C HH   I G V V   P +   +IGLSK  R++ +   RPQ+QE
Sbjct: 94  VSEMVLVNDVTLTSTCEHHFVTIDGMVSVAYYPKKW--VIGLSKINRIVAFFAQRPQVQE 151

Query: 177 EAVSQAADLLMQKLQPDGLAIVMEADHFCMHWRGVKDMDSKMINSVMRGSFLRDANLRRE 236
               Q        L+ D +A+ ++A HFC+  RG+KD +S  + S   G FL D   R+E
Sbjct: 152 RLTEQILLAFQTILETDDVAVYVKATHFCVKCRGIKDTNSYTVTSAFGGVFLDDRETRKE 211

Query: 237 FLALITQ 243
           FL LI +
Sbjct: 212 FLTLINK 218


>ML0223 [H] COG0302 GTP cyclohydrolase I Mle Mycobacterium leprae
          Length = 205

 Score =  119 bits (297), Expect = 8e-27,   Method: Compositional matrix adjust.
 Identities = 67/161 (41%), Positives = 86/161 (53%), Gaps = 1/161 (0%)

Query: 84  DTAKRVAKMYLNEVFKGRYQAAPPVTEFPNIERLNELMIVGPITVRSACSHHLCPIMGKV 143
           DT  RVA+    E+F G Y     V      E  NEL+IV  I + S C HHL    G  
Sbjct: 46  DTPARVARA-CRELFSGLYTDPQTVLNTMFDEEHNELVIVKEIPMYSTCEHHLVSFHGVA 104

Query: 144 WVGVMPNEHSNLIGLSKYARLLEWVMSRPQIQEEAVSQAADLLMQKLQPDGLAIVMEADH 203
            +G +P     + GLSK ARL++    RPQ+QE   SQ AD L+ KL P G+ IV+EA+H
Sbjct: 105 HIGYLPGADGRVTGLSKIARLVDLYAKRPQVQERLTSQIADALVSKLDPRGVIIVVEAEH 164

Query: 204 FCMHWRGVKDMDSKMINSVMRGSFLRDANLRREFLALITQR 244
            CM  RGV+   +    S +RG F  DA  R E L LI ++
Sbjct: 165 LCMAMRGVRKPGAITTTSAVRGQFKTDAASRAEALGLILRK 205