BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0035.0045.p (228 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PA4047 [H] COG0807 GTP cyclohydrolase II Pae Pseudomonas aeruginosa 275 7e-74 NMA1425 [H] COG0807 GTP cyclohydrolase II NmA Neisseria meningit... 243 2e-64 NMB1254 [H] COG0807 GTP cyclohydrolase II Nme Neisseria meningit... 241 1e-63 ribA [H] COG0807 GTP cyclohydrolase II Eco Escherichia coli K12 231 7e-61 ZribA [H] COG0807 GTP cyclohydrolase II EcZ Escherichia coli O15... 231 7e-61 >PA4047 [H] COG0807 GTP cyclohydrolase II Pae Pseudomonas aeruginosa Length = 205 Score = 275 bits (703), Expect = 7e-74, Method: Compositional matrix adjust. Identities = 135/192 (70%), Positives = 152/192 (79%) Query: 16 LVFVSSCKLPMPWATFELHAFYDEVSGKEHLALSLGEVGDGQPVLGRVHSECLTGDALFS 75 +VFV++ KLP P+ F +H F DE SGKEH+ALS+G++ DG PVLGR+HSECLTGDALFS Sbjct: 3 VVFVAASKLPTPFGEFTMHGFLDEESGKEHVALSMGDIADGAPVLGRLHSECLTGDALFS 62 Query: 76 QRCDCGAQLEAALKKIAKEGRGVLFYLRQEGRGIGLLNKIRAYHLQDQGADTVEANERLG 135 RCDCG QLE AL IA+EGRGVL YLRQEGRGIGLLNKIRAY LQD GADTVEAN +LG Sbjct: 63 LRCDCGFQLEGALAAIAEEGRGVLLYLRQEGRGIGLLNKIRAYELQDGGADTVEANLQLG 122 Query: 136 FPADMRRYTIVLPMLAHLKITSLRLMTNNPRKVKALEDSGITVAERIALIANHNPFNIGY 195 F AD R Y + PMLAHL ++SLRLMTNNPRKVKALE ITVAER+ L N N Y Sbjct: 123 FGADQRDYAMCQPMLAHLGVSSLRLMTNNPRKVKALESYAITVAERVPLQKGLNKHNRRY 182 Query: 196 LGTKARKLGHLL 207 L TKA KLGH+L Sbjct: 183 LATKAGKLGHML 194 >NMA1425 [H] COG0807 GTP cyclohydrolase II NmA Neisseria meningitidis Z2491 Length = 197 Score = 243 bits (621), Expect = 2e-64, Method: Compositional matrix adjust. Identities = 114/194 (58%), Positives = 144/194 (74%), Gaps = 1/194 (0%) Query: 14 EKLVFVSSCKLPMPWATFELHAFYDEVSGKEHLALSLGEVGDGQPVLGRVHSECLTGDAL 73 E L +V+SC+LP W F +H F +E G+EH+AL++G+ DG PVL R+HSECLTGDAL Sbjct: 3 ELLNYVASCRLPTEWGVFTMHGF-EEAGGQEHVALTVGDCSDGNPVLTRIHSECLTGDAL 61 Query: 74 FSQRCDCGAQLEAALKKIAKEGRGVLFYLRQEGRGIGLLNKIRAYHLQDQGADTVEANER 133 FS++CDCG QLEAA+K + EGRG++ YLRQEGRGIGL+NKIRAYHLQDQG DTVEAN Sbjct: 62 FSKKCDCGPQLEAAMKAVQAEGRGIIVYLRQEGRGIGLINKIRAYHLQDQGMDTVEANVA 121 Query: 134 LGFPADMRRYTIVLPMLAHLKITSLRLMTNNPRKVKALEDSGITVAERIALIANHNPFNI 193 LG P D R + + + +L I S++L+TNNP K++ L+D+GI V ERI L N N Sbjct: 122 LGLPVDARDFRLAQSIYEYLGIRSVKLLTNNPEKIQTLKDAGINVVERIPLHVGENLENK 181 Query: 194 GYLGTKARKLGHLL 207 YL TKA KLGHL+ Sbjct: 182 RYLQTKADKLGHLM 195 >NMB1254 [H] COG0807 GTP cyclohydrolase II Nme Neisseria meningitidis MC58 Length = 197 Score = 241 bits (614), Expect = 1e-63, Method: Compositional matrix adjust. Identities = 113/194 (58%), Positives = 143/194 (73%), Gaps = 1/194 (0%) Query: 14 EKLVFVSSCKLPMPWATFELHAFYDEVSGKEHLALSLGEVGDGQPVLGRVHSECLTGDAL 73 E L V+SC+LP W F +H F +E +G+EH+AL++G DG PVL R+HSECLTGDAL Sbjct: 3 EMLNHVASCRLPTEWGVFTMHGF-EEANGQEHVALTVGNFSDGNPVLTRIHSECLTGDAL 61 Query: 74 FSQRCDCGAQLEAALKKIAKEGRGVLFYLRQEGRGIGLLNKIRAYHLQDQGADTVEANER 133 FS++CDCG QLEAA++ + EGRG++ YLRQEGRGIGL+NKIRAYHLQDQG DTVEAN Sbjct: 62 FSRKCDCGPQLEAAMRAVQTEGRGIIVYLRQEGRGIGLINKIRAYHLQDQGMDTVEANLA 121 Query: 134 LGFPADMRRYTIVLPMLAHLKITSLRLMTNNPRKVKALEDSGITVAERIALIANHNPFNI 193 LG P D R + + + +L I S++L+TNNP K++ L+D+GI V ERI L N N Sbjct: 122 LGLPVDARDFRLAQSIYEYLGIRSVKLLTNNPEKIQTLKDAGINVVERIPLHVGENLENK 181 Query: 194 GYLGTKARKLGHLL 207 YL TKA KLGHL+ Sbjct: 182 RYLQTKADKLGHLM 195 >ribA [H] COG0807 GTP cyclohydrolase II Eco Escherichia coli K12 Length = 196 Score = 231 bits (590), Expect = 7e-61, Method: Compositional matrix adjust. Identities = 113/193 (58%), Positives = 138/193 (71%) Query: 15 KLVFVSSCKLPMPWATFELHAFYDEVSGKEHLALSLGEVGDGQPVLGRVHSECLTGDALF 74 +L V+ KLP PW F + F + +G +H+AL G++ PVL RVHSECLTGDALF Sbjct: 2 QLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALF 61 Query: 75 SQRCDCGAQLEAALKKIAKEGRGVLFYLRQEGRGIGLLNKIRAYHLQDQGADTVEANERL 134 S RCDCG QLEAAL +IA+EGRG+L Y RQEGR IGLLNKIRAY LQDQG DTVEAN +L Sbjct: 62 SLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQL 121 Query: 135 GFPADMRRYTIVLPMLAHLKITSLRLMTNNPRKVKALEDSGITVAERIALIANHNPFNIG 194 GF AD R +T+ M L + +RL+TNNP+KV+ L ++GI + ER+ LI NP N Sbjct: 122 GFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEH 181 Query: 195 YLGTKARKLGHLL 207 YL TKA K+GHLL Sbjct: 182 YLDTKAEKMGHLL 194 >ZribA [H] COG0807 GTP cyclohydrolase II EcZ Escherichia coli O157:H7 EDL933 Length = 196 Score = 231 bits (590), Expect = 7e-61, Method: Compositional matrix adjust. Identities = 113/193 (58%), Positives = 138/193 (71%) Query: 15 KLVFVSSCKLPMPWATFELHAFYDEVSGKEHLALSLGEVGDGQPVLGRVHSECLTGDALF 74 +L V+ KLP PW F + F + +G +H+AL G++ PVL RVHSECLTGDALF Sbjct: 2 QLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALF 61 Query: 75 SQRCDCGAQLEAALKKIAKEGRGVLFYLRQEGRGIGLLNKIRAYHLQDQGADTVEANERL 134 S RCDCG QLEAAL +IA+EGRG+L Y RQEGR IGLLNKIRAY LQDQG DTVEAN +L Sbjct: 62 SLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQL 121 Query: 135 GFPADMRRYTIVLPMLAHLKITSLRLMTNNPRKVKALEDSGITVAERIALIANHNPFNIG 194 GF AD R +T+ M L + +RL+TNNP+KV+ L ++GI + ER+ LI NP N Sbjct: 122 GFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEH 181 Query: 195 YLGTKARKLGHLL 207 YL TKA K+GHLL Sbjct: 182 YLDTKAEKMGHLL 194