BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0034.0102.p (411 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PA5542 [V] COG1680 Beta-lactamase class C and other penicillin b... 140 5e-33 PA2228 [V] COG1680 Beta-lactamase class C and other penicillin b... 140 7e-33 mll2884 [V] COG1680 Beta-lactamase class C and other penicillin ... 103 6e-22 mll2882 [V] COG1680 Beta-lactamase class C and other penicillin ... 100 5e-21 Rv1723 [V] COG1680 Beta-lactamase class C and other penicillin b... 99 1e-20 >PA5542 [V] COG1680 Beta-lactamase class C and other penicillin binding proteins Pae Pseudomonas aeruginosa Length = 414 Score = 140 bits (353), Expect = 5e-33, Method: Compositional matrix adjust. Identities = 96/346 (27%), Positives = 166/346 (47%), Gaps = 20/346 (5%) Query: 44 YLVGSFSAMDSIAPSCRQAPAAQPVPLPAADPETTMHYRYRNG--SWTLDDYMAHQRATA 101 Y ++ MD + P+ + PLPA + RYR G + +DD+M R Sbjct: 47 YQPDTYRNMDKVYPTRVIHKGTKVRPLPAG---VAIAPRYRIGGEEYGVDDFMRRNRVGG 103 Query: 102 VVVVKDGRIVAQRFNYGRTPQMRMLSNSMAKTVVALGILKALELGKIASLDDHAEDYVPA 161 V+++KDG++ +R+ G + R S S+ K++ + + A++ G +A LD + Y+P+ Sbjct: 104 VLILKDGKVALERYGLGNDERTRWTSFSVVKSISSTLVGAAVQQGLLA-LDQPVDKYLPS 162 Query: 162 LKGTLYGRTQLVNLLRMASGARFSEDYT--PNDDRAIFVRKL-RREGTLAAVQSISERAA 218 L G+ Y + +L+M+SG R++E Y +D R +F +L R G + + + R Sbjct: 163 LAGSAYQGVTVEQVLQMSSGVRWNETYRDPKSDRRQMFDAQLAERPGGILRLLASLPRQY 222 Query: 219 PEGERFNYAGAQTSVLGLVLQGATGQDMCQWIGEQIWQPMGAAAEATWLLNPVDQQALAQ 278 P G F Y+ ++ + +L AT + ++ E+IW MG ++ W L Q + Sbjct: 223 PSGTHFTYSTGESHLQSELLHAATRIPVSDYLSERIWARMGMESDGFWQLESPAGQEIGS 282 Query: 279 GGFNATVYDYARLGMLLANDGVANGQQVIAREHVLAMTDPARQPPAFRPGVMLDSHGRTY 338 G +AT+ DY R G + DGV +G++++ E + PG + D G Sbjct: 283 SGLSATLRDYGRFGQFVLEDGVIDGERILP-EGWVDRASRVEASSHLAPGKLYD--GEYA 339 Query: 339 FGYGYQVWIMPGSHR--------RFALLGIYGQAVFVEPELKLVMV 376 GYGYQ W P + F GI+GQ +++ + K+V V Sbjct: 340 LGYGYQWWTFPVGAKALPEHDGGAFEAQGIFGQYLYINRKEKIVAV 385 >PA2228 [V] COG1680 Beta-lactamase class C and other penicillin binding proteins Pae Pseudomonas aeruginosa Length = 403 Score = 140 bits (352), Expect = 7e-33, Method: Compositional matrix adjust. Identities = 96/291 (32%), Positives = 150/291 (51%), Gaps = 6/291 (2%) Query: 90 LDDYMAHQRATAVVVVKDGRIVAQRFNYGRTPQMRMLSNSMAKTVVALGILKALELGKIA 149 D++A T ++V+ D RI + + G + + + S++K++++L I A++ G I Sbjct: 86 FKDWLASSNTTGLIVLSDDRIAFEEYYLGNSAKSLAIGWSLSKSLMSLLIGMAVDEGSIH 145 Query: 150 SLDDHAEDYVPALKGTLYGRTQLVNLLRMASGARFSEDYTPND-DRAIFVRKLRREGTLA 208 SL D Y P L Y L ++L M+SG FSEDY +D D R + G++ Sbjct: 146 SLLDPVNLYAPQLSAGGYAGVSLRDVLEMSSGIAFSEDYGNSDSDINQLGRTIALGGSVN 205 Query: 209 AVQSISERAAPEGERFNYAGAQTSVLGLVLQGATGQDMCQWIGEQIWQPMGAAAEATWLL 268 S R G +Y T VLG+VL GATG Q++ +++W +GA E WL Sbjct: 206 EKVSSLRREDAPGRVHHYVSVDTQVLGMVLLGATGMGPSQFMNQRLWPQLGAECEGAWLT 265 Query: 269 NPVDQQALAQGGFNATVYDYARLGMLLANDGVA-NGQQVIAREHVLAMTDPARQPPAFRP 327 + + LA GG N + D+AR+G+L + G + G Q+++ E V A T P + RP Sbjct: 266 DDRGTE-LAFGGVNLCLRDFARIGLLFLHGGRSLTGSQIVSAEWVKASTKP--RSAHLRP 322 Query: 328 GVMLDSHGRTYFGYGYQVWIMPGSHRRFALLGIYGQAVFVEPELKLVMVHT 378 G ++ G GYGYQ WI G F +G+YGQ ++V P ++V+ T Sbjct: 323 GRYIED-GEPNLGYGYQWWIPEGKEGEFLAIGVYGQFIYVNPLRRVVIAKT 372 >mll2884 [V] COG1680 Beta-lactamase class C and other penicillin binding proteins Mlo Mesorhizobium loti Length = 385 Score = 103 bits (258), Expect = 6e-22, Method: Compositional matrix adjust. Identities = 85/323 (26%), Positives = 138/323 (42%), Gaps = 39/323 (12%) Query: 89 TLDDYMAHQRATAVVVVKDGRIVAQRFNYGRTPQMRMLSNSMAKTVVA--LGILKALELG 146 TL + +V+K G++ +R+ G + LS SMAK++ GIL L Sbjct: 68 TLAGLLDETYTDGFLVLKHGKVAYERYFNGMDERTLHLSQSMAKSITGSVFGILAGRGLI 127 Query: 147 KIASLDDHAEDYVPALKGTLYGRTQLVNLLRMASGARFSEDYTPNDDRAIFVRKLR---- 202 A DY+P L T + + ++L M +G RFSE+YT DR + ++ Sbjct: 128 DPAR---PVTDYLPELGATGWAGASVQHVLDMTTGVRFSEEYT---DRYSDIGQVDVATG 181 Query: 203 --------------REGTLAAVQSISERAAPEGERFNYAGAQTSVLGLVLQGATGQDMCQ 248 + + + P G F Y +T VL +++ TG+ + Q Sbjct: 182 WKPVPPGSDPDFRWPSHMFELILGLKDTVRPHGAAFEYRSIETDVLAFIMERVTGKRLAQ 241 Query: 249 WIGEQIWQPMGAAAEATWLLNPVDQQALAQGGFNATVYDYARLGMLLANDGVANGQQVIA 308 + E++WQ +GA A + ++ A+A GGFNAT+ DY R G L+ + NG ++ Sbjct: 242 LVSEELWQKLGADESACFTVDSA-GYAVADGGFNATLRDYGRFGQLILD----NGGGIVP 296 Query: 309 REHVLAMTDPARQPPAFRPGVMLDSHGRTYFGYGYQVWIMPGSHRRFALLGIYGQAVFVE 368 + + A T R P F P + S Y Q WI R G++GQ + ++ Sbjct: 297 ADWIEA-TRNGRHGPDFSPSLPEGS-------YRNQFWIENPRSRALMCRGVFGQMIHID 348 Query: 369 PELKLVMVHTGVGRDAAGDASGT 391 +V+V D + A T Sbjct: 349 WNTGMVVVKLSTWPDFSNLACST 371 >mll2882 [V] COG1680 Beta-lactamase class C and other penicillin binding proteins Mlo Mesorhizobium loti Length = 393 Score = 100 bits (250), Expect = 5e-21, Method: Compositional matrix adjust. Identities = 79/298 (26%), Positives = 141/298 (47%), Gaps = 19/298 (6%) Query: 89 TLDDYMAHQRATAVVVVKDGRIVAQRFNYGRTPQMRMLSNSMAKTVVALGILKALELGKI 148 T+ +++ R A+ V+K G+++ F R + S++K+V A+ + LE + Sbjct: 75 TVAEFLIRSRTDALTVMKGGKVIGDWFAPHMDFGARHIIFSISKSVTAI-VAGTLEGEGV 133 Query: 149 ASLDDHAEDYVPALKGTLYGRTQLVNLLRMASGARFSEDYTPNDDRAIFVRKLR------ 202 + Y+P G+ YG ++L M+ F E Y D + F R R Sbjct: 134 FDPEAPVTTYIPEAAGSAYGDASCRHVLDMSVSLDFEEAYL--DPESAFARYRRATLWNP 191 Query: 203 ---REGTLAAVQSISERAAPEGERFNYAGAQTSVLGLVLQGATGQDMCQWIGEQIWQPMG 259 E + S+ A P G+ F Y + +LGL+L+ A+GQ + E++W P+G Sbjct: 192 GGGTESLREFILSLQRLAEPHGQTFRYRSPNSDLLGLLLERASGQRFSDLMREKLWLPLG 251 Query: 260 AAAEATWLLNPVDQQALAQGGFNATVYDYARLGMLLANDGVANGQQVIAREHVLAMTDPA 319 A ++A+ ++ ++ A GG + T D AR+G ++ G ANG++++ V Sbjct: 252 AVSDASIGVD-MEGTARTAGGISVTPRDLARVGEMMRQGGTANGRRIVPEAWVRDTVSTG 310 Query: 320 RQPPAFRPGVM--LDSHGRTYFGYGYQVWIMPGSHRRFALLGIYGQAVFVEPELKLVM 375 A+ G M L HGR Y YQ G+ + +GI+GQ ++V+P+ ++V+ Sbjct: 311 GSAEAWHRGTMAFLFPHGR-YRDKWYQTGKPSGA---YCGIGIHGQWLYVDPKAEVVI 364 >Rv1723 [V] COG1680 Beta-lactamase class C and other penicillin binding proteins Mtu Mycobacterium tuberculosis H37Rv Length = 415 Score = 99.4 bits (246), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 111/368 (30%), Positives = 162/368 (44%), Gaps = 31/368 (8%) Query: 29 GYPAGANLQQAYQQPYLVGSFSAMDSIAPSCRQAPAAQPV-PLPAAD-PETTMHYRYRNG 86 G PAG L PY +F ++ P+ A +PV LPA + P + +G Sbjct: 4 GVPAGLALDNWLSSPYSHWAFQHVEDFMPTTVIARGTEPVVTLPADNAPIADIGLTSTDG 63 Query: 87 -SWTLDDYMAHQRATAVVVVKDGRIVAQRFNYGRTPQMRMLSNSMAKTVVALGILKALEL 145 + T+ MA V G +VA+++ G P+ R L S++K++VA ++ AL Sbjct: 64 IATTVGAVMAATATDGWAVAHRGALVAEQYLDGLGPRTRHLLFSVSKSLVA-AVVGALHG 122 Query: 146 GKIASLDDHAEDYVPALKGTLYGRTQLVNLLRMASGARFSEDYTPNDDRA--IFVRKL-- 201 LD YVPAL Y + +LL M SG FSE+Y DD A I VR+ Sbjct: 123 AGAIELDAPVTAYVPALADCGYAGATVRHLLDMRSGVAFSENY---DDPAAEIHVREQVI 179 Query: 202 ----RREGTLAAVQS----ISERAAPEGERFNYAGAQTSVLGLVLQGATGQDMCQWIGEQ 253 +R L A R + G F Y +T VLG + + A GQ M + + E Sbjct: 180 GWAPKRGPDLPATLRDYLLTLRRKSAHGGPFEYRSCETDVLGWICEAAAGQPMPELMSEL 239 Query: 254 IWQPMGAAAEATWLLNPVDQ--QALAQGGFNATVYDYARLGMLLANDGVA-NGQQVIARE 310 +W +GA +AT L+ + GG +A + D R G L DGV+ GQQV+ Sbjct: 240 LWSRIGAQCDATIALDVAGAAGTGIFDGGISACLTDMIRFGSLYLRDGVSLAGQQVVPAA 299 Query: 311 HVLAMTD---PARQPPAFRPGVMLDSHGRTYFGYGYQVWI-MPGSHRRFALLGIYGQAVF 366 + D +RQ A P D + Y QVW PGS+ +G+ GQ ++ Sbjct: 300 WIADTFDGGPDSRQAFAASP----DDNPMPGGMYRNQVWFPYPGSNVALC-VGMCGQLIY 354 Query: 367 VEPELKLV 374 V ++V Sbjct: 355 VNRAAEVV 362