BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0032.0119.p (336 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc0540 [R] COG2334 Putative homoserine kinase type II (protein ... 452 e-127 PA0486 [R] COG2334 Putative homoserine kinase type II (protein k... 343 4e-94 VC0035 [R] COG2334 Putative homoserine kinase type II (protein k... 328 9e-90 YPO0014 [R] COG2334 Putative homoserine kinase type II (protein ... 315 1e-85 ZyihE [R] COG2334 Putative homoserine kinase type II (protein ki... 303 3e-82 >RSc0540 [R] COG2334 Putative homoserine kinase type II (protein kinase fold) Rso Ralstonia solanacearum Length = 347 Score = 452 bits (1164), Expect = e-127, Method: Compositional matrix adjust. Identities = 224/348 (64%), Positives = 265/348 (76%), Gaps = 15/348 (4%) Query: 1 MNQSAAPDQPDATS--FATLSPDTVLDALAAQGLYGDGRLLALNSYENRVYQVGMEEGPP 58 M P PDA+ +A L+PD++LDALA G DGR+ ALNSYENRVYQ G+E+G P Sbjct: 1 MRHDGQPPSPDASEAPYAGLTPDSILDALAQVGRMPDGRMFALNSYENRVYQAGIEDGAP 60 Query: 59 LVAKFYRPLRWTDEQILEEHAFSQELADDEVPVVPAMRLENGRTLHRHAGFRFAVFRRHG 118 +V KFYRP RW D QI+EEHAF+ ELA E+PVV + + +GRTLH + FAVF R Sbjct: 61 VVVKFYRPGRWNDAQIVEEHAFTAELAAAEIPVVAPLEI-DGRTLHAFDRWHFAVFPRCA 119 Query: 119 GRAPELDDADTLERLGRFIGRIHAVGLRQPFVHRPALDLASFGAEPRDWLLAHDFIPMDV 178 GR P +D DTLE +GRF+GRIHAVG R+PF+ RP LD+ +FG + RDWLL HDFIP D+ Sbjct: 120 GRVPAIDRDDTLEWMGRFLGRIHAVGARRPFMARPTLDIDTFGVQSRDWLLEHDFIPPDL 179 Query: 179 ATAWRTTVEQALAGVQRCYERAGQIRTLRLHGDCHVGNVLWTD------------AGPHF 226 AWR+ + AL GV+RCY+RAG++ LRLHGDCH NVLW D AGPHF Sbjct: 180 LPAWRSVADAALDGVRRCYDRAGEVAMLRLHGDCHASNVLWIDEADALKNDPLRSAGPHF 239 Query: 227 VDFDDSRSGPAVQDLWMLLSGERREMVGQLADLLAGYESFCEFEPRELYLIEALRTLRLI 286 VDFDDSR+GPAVQDLWMLLSG+R M QLA +LAGYE FC F+ REL+L+EALRTLRL+ Sbjct: 240 VDFDDSRTGPAVQDLWMLLSGDRASMRHQLASVLAGYEDFCAFDTRELHLVEALRTLRLL 299 Query: 287 HYSAWLARRWDDPAFPAAFPWFNTQRYWQDRILELREQIALMDEAPLW 334 HYSAWLARRW+DPAFPAAFPWFNTQRYWQDR+LELREQIAL+DE PLW Sbjct: 300 HYSAWLARRWNDPAFPAAFPWFNTQRYWQDRVLELREQIALLDEPPLW 347 >PA0486 [R] COG2334 Putative homoserine kinase type II (protein kinase fold) Pae Pseudomonas aeruginosa Length = 324 Score = 343 bits (880), Expect = 4e-94, Method: Compositional matrix adjust. Identities = 174/319 (54%), Positives = 225/319 (70%), Gaps = 2/319 (0%) Query: 15 FATLSPDTVLDALAAQGLYGDGRLLALNSYENRVYQVGMEEGPPLVAKFYRPLRWTDEQI 74 F L+PD VLDA+ + G D R+LALNSYENRVYQVG+E+G PL+AKFYRP RW+D I Sbjct: 5 FDQLTPDLVLDAVESLGYLSDARVLALNSYENRVYQVGIEDGEPLIAKFYRPDRWSDAAI 64 Query: 75 LEEHAFSQELADDEVPVVPAMRLENGRTLHRHAGFRFAVFRRHGGRAPELDDADTLERLG 134 EEHAFS ELA+ EVPVV + +G +L +GFRFA+F R GGRAPE + D L RLG Sbjct: 65 REEHAFSAELAECEVPVVAPLS-RDGESLFAFSGFRFALFPRRGGRAPEPGNLDQLYRLG 123 Query: 135 RFIGRIHAVGLRQPFVHRPALDLASFGAEPRDWLLAHDFIPMDVATAWRTTVEQALAGVQ 194 + +GR+HAVG +PF HR AL + +FG LL +FIP + A+ + L + Sbjct: 124 QLLGRLHAVGATRPFEHREALAVDNFGHASLATLLEGNFIPRSLLPAYESVARDLLKRLD 183 Query: 195 RCYERAGQIRTLRLHGDCHVGNVLWTDAGPHFVDFDDSRSGPAVQDLWMLLSGERREMVG 254 + + +RLHGDCH GN+L D H VD DD R GPA+QDLWM+L+GER E + Sbjct: 184 ALFAEV-PYQPIRLHGDCHPGNLLCRDDVYHMVDLDDCRMGPALQDLWMMLAGERHERLA 242 Query: 255 QLADLLAGYESFCEFEPRELYLIEALRTLRLIHYSAWLARRWDDPAFPAAFPWFNTQRYW 314 Q+A+L+ GY F +F+PR+L L+E LR+LRL+HYSAWLARRWDDPAFP +FPWF ++RYW Sbjct: 243 QIAELVDGYNEFHDFDPRQLPLLEGLRSLRLMHYSAWLARRWDDPAFPPSFPWFGSERYW 302 Query: 315 QDRILELREQIALMDEAPL 333 +++L LREQ+A +DE PL Sbjct: 303 GEQVLVLREQLAALDEEPL 321 >VC0035 [R] COG2334 Putative homoserine kinase type II (protein kinase fold) Vch Vibrio cholerae Length = 340 Score = 328 bits (842), Expect = 9e-90, Method: Compositional matrix adjust. Identities = 163/319 (51%), Positives = 217/319 (68%), Gaps = 4/319 (1%) Query: 15 FATLSPDTVLDALAAQGLYGDGRLLALNSYENRVYQVGMEEGPPLVAKFYRPLRWTDEQI 74 F L+PD + AL + G+ + L LNSYENRVYQ EE V KFYRP RWTDEQI Sbjct: 20 FDALTPDLIWYALESIGIRAESGFLPLNSYENRVYQFTDEERRRFVVKFYRPQRWTDEQI 79 Query: 75 LEEHAFSQELADDEVPVVPAMRLENGRTLHRHAGFRFAVFRRHGGRAPELDDADTLERLG 134 EEH F+ EL +E+P+VP +RL NG TLH + G+RFA+F GGR E+D+ + LE +G Sbjct: 80 QEEHDFALELEQEEIPIVPPLRL-NGATLHHYQGYRFALFTSMGGRQYEVDNEEHLEWVG 138 Query: 135 RFIGRIHAVGLRQPFVHRPALDLASFGAEPRDWLLAHDFIPMDVATAWRTTVEQALAGVQ 194 RF+GRIH VG +PF+HRP L L + +PR L IP + + ++ +A ++ Sbjct: 139 RFLGRIHKVGASKPFLHRPTLSLDEYLHQPRHTLEYSHCIPAHLQRVFFHDLDILIAEIK 198 Query: 195 RCYERAGQIRTLRLHGDCHVGNVLWTDAGPHFVDFDDSRSGPAVQDLWMLLSGERREMVG 254 + + +RLHGDCH GN+LW D GP FVD DD+R+GPA+QDLWMLL G+R++ + Sbjct: 199 QHW--VPTQPQIRLHGDCHPGNILWRD-GPMFVDLDDARNGPAIQDLWMLLHGDRQDKLI 255 Query: 255 QLADLLAGYESFCEFEPRELYLIEALRTLRLIHYSAWLARRWDDPAFPAAFPWFNTQRYW 314 QL +L GY+ FC+F P++L LIE LR LR++HY AWLA+RW DPAFP AFPWFN +YW Sbjct: 256 QLDIVLEGYQEFCDFNPQQLKLIEPLRGLRMVHYMAWLAKRWQDPAFPIAFPWFNDAKYW 315 Query: 315 QDRILELREQIALMDEAPL 333 +++IL +EQIA + E PL Sbjct: 316 ENQILAFKEQIATLQEPPL 334 >YPO0014 [R] COG2334 Putative homoserine kinase type II (protein kinase fold) Ype Yersinia pestis Length = 328 Score = 315 bits (806), Expect = 1e-85, Method: Compositional matrix adjust. Identities = 160/322 (49%), Positives = 204/322 (63%), Gaps = 4/322 (1%) Query: 12 ATSFATLSPDTVLDALAAQGLYGDGRLLALNSYENRVYQVGMEEGPPLVAKFYRPLRWTD 71 A +F TLSPD ++DAL GL D L ALNSYENRVYQ EE V KFYRP RW+ Sbjct: 5 AFNFQTLSPDLIMDALEGAGLRVDSGLTALNSYENRVYQFMDEESKRYVVKFYRPERWSS 64 Query: 72 EQILEEHAFSQELADDEVPVVPAMRLENGRTLHRHAGFRFAVFRRHGGRAPELDDADTLE 131 EQI EEH FS +LA+ E+PV+ +RL NG+TLH H GF FAVF GGR E+D+ D LE Sbjct: 65 EQITEEHQFSLDLAESEIPVIAPLRL-NGKTLHTHCGFFFAVFPSVGGRQYEIDNLDQLE 123 Query: 132 RLGRFIGRIHAVGLRQPFVHRPALDLASFGAEPRDWLLAHDFIPMDVATAWRTTVEQALA 191 +GRF+GRIH FV RP + + + EPR L D +P+ + + + Sbjct: 124 WVGRFLGRIHQAARNSLFVARPTMGIEEYLTEPRQLLANCDLVPVKQRDKFLAAADLLIT 183 Query: 192 GVQRCYERAGQIRTLRLHGDCHVGNVLWTDAGPHFVDFDDSRSGPAVQDLWMLLSGERRE 251 +++ + Q LRLHGDCH GN+LW D GP FVD DD+R+GPA+QDLWMLL G+RR+ Sbjct: 184 TIKQYWHTEWQ--PLRLHGDCHPGNILWRD-GPMFVDLDDARNGPAIQDLWMLLHGDRRD 240 Query: 252 MVGQLADLLAGYESFCEFEPRELYLIEALRTLRLIHYSAWLARRWDDPAFPAAFPWFNTQ 311 QL LL Y F +F+ REL LIE LR +R+++Y AW+ARRW DPAFP +FPW Sbjct: 241 QSMQLDILLEAYSEFADFDQRELALIEPLRAMRMVYYLAWVARRWQDPAFPKSFPWMAES 300 Query: 312 RYWQDRILELREQIALMDEAPL 333 +W + EQ+ L+ E PL Sbjct: 301 DFWLQQTASFTEQVKLLQEPPL 322 >ZyihE [R] COG2334 Putative homoserine kinase type II (protein kinase fold) EcZ Escherichia coli O157:H7 EDL933 Length = 328 Score = 303 bits (777), Expect = 3e-82, Method: Compositional matrix adjust. Identities = 155/322 (48%), Positives = 200/322 (62%), Gaps = 4/322 (1%) Query: 12 ATSFATLSPDTVLDALAAQGLYGDGRLLALNSYENRVYQVGMEEGPPLVAKFYRPLRWTD 71 A +F TL PDT++DAL QG+ D L LNSYENRVYQ E+ V KFYRP RWT Sbjct: 5 AFTFQTLHPDTIMDALFEQGIRVDSGLTPLNSYENRVYQFQDEDRRRFVVKFYRPERWTA 64 Query: 72 EQILEEHAFSQELADDEVPVVPAMRLENGRTLHRHAGFRFAVFRRHGGRAPELDDADTLE 131 +QILEEH F+ +L +DEVPV + NG+TL H GF FAVF GGR E D+ D +E Sbjct: 65 DQILEEHQFALQLVNDEVPVAAPVAF-NGQTLLNHQGFYFAVFPSVGGRQFEADNIDQME 123 Query: 132 RLGRFIGRIHAVGLRQPFVHRPALDLASFGAEPRDWLLAHDFIPMDVATAWRTTVEQALA 191 +GR++GR+H G +Q F+HRP + L + EPR IP + A+ ++ +A Sbjct: 124 AVGRYLGRMHQTGRKQLFIHRPTIGLNEYLIEPRKLFEDATLIPSGLKAAFLKATDELIA 183 Query: 192 GVQRCYERAGQIRTLRLHGDCHVGNVLWTDAGPHFVDFDDSRSGPAVQDLWMLLSGERRE 251 V + LRLHGDCH GN+LW D GP FVD DD+R+GPA+QDLWMLL+G++ E Sbjct: 184 AVTAHWRE--DFTVLRLHGDCHAGNILWRD-GPMFVDLDDARNGPAIQDLWMLLNGDKAE 240 Query: 252 MVGQLADLLAGYESFCEFEPRELYLIEALRTLRLIHYSAWLARRWDDPAFPAAFPWFNTQ 311 QL ++ YE F EF+ E+ LIE LR +RL++Y AWL RRW DPAFP FPW + Sbjct: 241 QRMQLETIIEAYEEFSEFDTAEIGLIEPLRAMRLVYYLAWLMRRWADPAFPKNFPWLTGE 300 Query: 312 RYWQDRILELREQIALMDEAPL 333 YW + EQ ++ E PL Sbjct: 301 DYWLRQTATFIEQAKVLQEPPL 322