BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0032.0111.p (450 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PM0813 [E] COG0137 Argininosuccinate synthase Pmu Pasteurella mu... 746 0.0 NMB2129 [E] COG0137 Argininosuccinate synthase Nme Neisseria men... 730 0.0 NMA0303 [E] COG0137 Argininosuccinate synthase NmA Neisseria men... 730 0.0 RSc2553 [E] COG0137 Argininosuccinate synthase Rso Ralstonia sol... 728 0.0 YPO1570 [E] COG0137 Argininosuccinate synthase Ype Yersinia pestis 716 0.0 >PM0813 [E] COG0137 Argininosuccinate synthase Pmu Pasteurella multocida Length = 445 Score = 746 bits (1926), Expect = 0.0, Method: Compositional matrix adjust. Identities = 367/449 (81%), Positives = 396/449 (88%), Gaps = 8/449 (1%) Query: 1 MSN-ILQSVPVNQKVGIAFSGGLDTSAALTWMRQKGAIPYAYTANLGQPDEPDYDAIPKK 59 MSN ILQ +P QKVGIAFSGGLDTSAAL WMRQKGA+PYAYTANLGQPDE DY+AIP+K Sbjct: 1 MSNTILQQLPKGQKVGIAFSGGLDTSAALLWMRQKGAVPYAYTANLGQPDEEDYNAIPRK 60 Query: 60 AMQYGAQQARLIDCREQLANEGIAALQSGAFHISTAGITYFNTTPLGRAVTGTMLVSAMR 119 AM+YGA+ ARLIDCR QLA+EGIAA+QSGAFHIST G+TYFNTTPLGRAVTGTMLVSAMR Sbjct: 61 AMEYGAENARLIDCRAQLAHEGIAAIQSGAFHISTGGVTYFNTTPLGRAVTGTMLVSAMR 120 Query: 120 EDNVDIWGDGSTYKGNDIERFYRYGLLVNPNLKIYKPWLDSTFIDELGGRKEMSEFMIKS 179 ED+V+IWGDGST+KGNDIERFYRYGLL NPNLKIYKPWLD+ FI+ELGGR EMSEF+I + Sbjct: 121 EDDVNIWGDGSTFKGNDIERFYRYGLLTNPNLKIYKPWLDNQFIEELGGRHEMSEFLIAN 180 Query: 180 GFDYKMSVEKAYSTDSNMLGATHEAKDLEFLNSGIKIVQPIMGVAFWRDDVEVKAETVTV 239 GF+YKMSVEKAYSTDSNMLGATHEAKDLEFLN+GI+IV+PIMGVAFWRDDVEVKAE VTV Sbjct: 181 GFEYKMSVEKAYSTDSNMLGATHEAKDLEFLNTGIRIVKPIMGVAFWRDDVEVKAEEVTV 240 Query: 240 RFEEGRPVALNGKTFASMTELILEANRIGGRHGLGMSDQIENRIIEAKSRGIYEAPGLAL 299 RFEEG PVALNGKTF+ EL LEANRIGGRHGLGMSDQIENRIIEAKSRGIYEAPG+AL Sbjct: 241 RFEEGIPVALNGKTFSDHVELFLEANRIGGRHGLGMSDQIENRIIEAKSRGIYEAPGMAL 300 Query: 300 LFIAYERLVTGIHNEDTIEQYRDNGRKLGRLLYQGRWFDSQAIMLRETXPRPLVRFAGHH 359 L IAYERLV+GIHNEDTIEQYR NG +LGRLLYQGRWFD QA+MLRET R + R Sbjct: 301 LHIAYERLVSGIHNEDTIEQYRINGLRLGRLLYQGRWFDPQALMLRETAQRWVAR----- 355 Query: 360 AAITGEVTVELRRGNDYSILNTESPNLTYHPERLTMEKGEGS-FSAIDRIGQLTMRNLDI 418 AITGEVT ELRRGNDYSILNTESPNLTY PERL+MEK E + F +DRIGQLTMRNLDI Sbjct: 356 -AITGEVTFELRRGNDYSILNTESPNLTYMPERLSMEKVENAPFDPVDRIGQLTMRNLDI 414 Query: 419 ADTRQKLAIYQNTGLLESSTAVSLPLLGK 447 DTR KL IY TGLL S LP L K Sbjct: 415 VDTRDKLGIYTQTGLLSISKDSFLPQLNK 443 >NMB2129 [E] COG0137 Argininosuccinate synthase Nme Neisseria meningitidis MC58 Length = 447 Score = 730 bits (1884), Expect = 0.0, Method: Compositional matrix adjust. Identities = 355/447 (79%), Positives = 388/447 (86%), Gaps = 7/447 (1%) Query: 4 ILQSVPVNQKVGIAFSGGLDTSAALTWMRQKGAIPYAYTANLGQPDEPDYDAIPKKAMQY 63 ILQS+PV QKVGIAFSGGLDTSAAL WM+ KGA+PYAYTANLGQPDE DY+AIPKKAM+Y Sbjct: 7 ILQSLPVGQKVGIAFSGGLDTSAALLWMKLKGALPYAYTANLGQPDEDDYNAIPKKAMEY 66 Query: 64 GAQQARLIDCREQLANEGIAALQSGAFHISTAGITYFNTTPLGRAVTGTMLVSAMREDNV 123 GA+ ARLIDCR QLA+EGIAA+Q GAFH+ST GI YFNTTPLGRAVTGTMLVSAM+ED+V Sbjct: 67 GAENARLIDCRAQLAHEGIAAIQCGAFHVSTGGIAYFNTTPLGRAVTGTMLVSAMKEDDV 126 Query: 124 DIWGDGSTYKGNDIERFYRYGLLVNPNLKIYKPWLDSTFIDELGGRKEMSEFMIKSGFDY 183 +IWGDGSTYKGNDIERFYRYGLL NP LKIYKPWLD FIDELGGR EMSEF+I +GF+Y Sbjct: 127 NIWGDGSTYKGNDIERFYRYGLLTNPALKIYKPWLDQQFIDELGGRHEMSEFLIANGFNY 186 Query: 184 KMSVEKAYSTDSNMLGATHEAKDLEFLNSGIKIVQPIMGVAFWRDDVEVKAETVTVRFEE 243 KMSVEKAYSTDSNMLGATHEAKDLEFLNSGIKIV+PIMGVAFW ++VEV E V+VRFEE Sbjct: 187 KMSVEKAYSTDSNMLGATHEAKDLEFLNSGIKIVKPIMGVAFWDENVEVSPEEVSVRFEE 246 Query: 244 GRPVALNGKTFASMTELILEANRIGGRHGLGMSDQIENRIIEAKSRGIYEAPGLALLFIA 303 G PVALNGK +A EL LEANRIGGRHGLGMSDQIENRIIEAKSRGIYEAPG+AL IA Sbjct: 247 GVPVALNGKEYADPVELFLEANRIGGRHGLGMSDQIENRIIEAKSRGIYEAPGMALFHIA 306 Query: 304 YERLVTGIHNEDTIEQYRDNGRKLGRLLYQGRWFDSQAIMLRETXPRPLVRFAGHHAAIT 363 YERLVTGIHNEDTIEQYR NG +LGRLLYQGRWFDSQA+MLRET R + + A+T Sbjct: 307 YERLVTGIHNEDTIEQYRINGLRLGRLLYQGRWFDSQALMLRETAQRWVAK------AVT 360 Query: 364 GEVTVELRRGNDYSILNTESPNLTYHPERLTMEKGE-GSFSAIDRIGQLTMRNLDIADTR 422 GEVT+ELRRGNDYSILNTESPNLTY PERL+MEK E +F+ +DRIGQLTMRNLDI DTR Sbjct: 361 GEVTLELRRGNDYSILNTESPNLTYQPERLSMEKVEDAAFTPLDRIGQLTMRNLDITDTR 420 Query: 423 QKLAIYQNTGLLESSTAVSLPLLGKDE 449 KL IY +GLL LP LG + Sbjct: 421 VKLGIYSQSGLLSLGEGSVLPQLGNKQ 447 >NMA0303 [E] COG0137 Argininosuccinate synthase NmA Neisseria meningitidis Z2491 Length = 447 Score = 730 bits (1884), Expect = 0.0, Method: Compositional matrix adjust. Identities = 354/447 (79%), Positives = 389/447 (87%), Gaps = 7/447 (1%) Query: 4 ILQSVPVNQKVGIAFSGGLDTSAALTWMRQKGAIPYAYTANLGQPDEPDYDAIPKKAMQY 63 ILQ++PV QKVGIAFSGGLDTSAAL WM+ KGA+PYAYTANLGQPDE DY+AIPKKAM+Y Sbjct: 7 ILQNLPVGQKVGIAFSGGLDTSAALLWMKLKGALPYAYTANLGQPDEDDYNAIPKKAMEY 66 Query: 64 GAQQARLIDCREQLANEGIAALQSGAFHISTAGITYFNTTPLGRAVTGTMLVSAMREDNV 123 GA+ ARLIDCR QLA+EGIAA+Q GAFH+ST GI YFNTTPLGRAVTGTMLVSAM+ED+V Sbjct: 67 GAENARLIDCRAQLAHEGIAAIQCGAFHVSTGGIAYFNTTPLGRAVTGTMLVSAMKEDDV 126 Query: 124 DIWGDGSTYKGNDIERFYRYGLLVNPNLKIYKPWLDSTFIDELGGRKEMSEFMIKSGFDY 183 +IWGDGSTYKGNDIERFYRYGLL NP LKIYKPWLD FIDELGGR EMSEF+I +GF+Y Sbjct: 127 NIWGDGSTYKGNDIERFYRYGLLTNPALKIYKPWLDQQFIDELGGRHEMSEFLIANGFNY 186 Query: 184 KMSVEKAYSTDSNMLGATHEAKDLEFLNSGIKIVQPIMGVAFWRDDVEVKAETVTVRFEE 243 KMSVEKAYSTDSNMLGATHEAKDLEFLNSGIKIV+PIMG+AFW ++VE+K E V+VRFEE Sbjct: 187 KMSVEKAYSTDSNMLGATHEAKDLEFLNSGIKIVKPIMGIAFWDENVEIKPEEVSVRFEE 246 Query: 244 GRPVALNGKTFASMTELILEANRIGGRHGLGMSDQIENRIIEAKSRGIYEAPGLALLFIA 303 G PVALNGK +A EL LEANRIGGRHGLGMSDQIENRIIEAKSRGIYEAPG+AL IA Sbjct: 247 GVPVALNGKEYADPVELFLEANRIGGRHGLGMSDQIENRIIEAKSRGIYEAPGMALFHIA 306 Query: 304 YERLVTGIHNEDTIEQYRDNGRKLGRLLYQGRWFDSQAIMLRETXPRPLVRFAGHHAAIT 363 YERLVTGIHNEDTIEQYR NG +LGRLLYQGRWFDSQA+MLRET R + + AIT Sbjct: 307 YERLVTGIHNEDTIEQYRINGLRLGRLLYQGRWFDSQALMLRETAQRWVAK------AIT 360 Query: 364 GEVTVELRRGNDYSILNTESPNLTYHPERLTMEKGE-GSFSAIDRIGQLTMRNLDIADTR 422 GEVT+ELRRGNDYSILNTESPNLTY PERL+MEK E +F+ +DRIGQLTMRNLDI DTR Sbjct: 361 GEVTLELRRGNDYSILNTESPNLTYQPERLSMEKVEDAAFTPLDRIGQLTMRNLDITDTR 420 Query: 423 QKLAIYQNTGLLESSTAVSLPLLGKDE 449 KL IY +GLL LP LG + Sbjct: 421 AKLGIYSQSGLLALGEGSVLPQLGNKQ 447 >RSc2553 [E] COG0137 Argininosuccinate synthase Rso Ralstonia solanacearum Length = 445 Score = 728 bits (1878), Expect = 0.0, Method: Compositional matrix adjust. Identities = 355/451 (78%), Positives = 388/451 (86%), Gaps = 7/451 (1%) Query: 1 MSNILQSVPVNQKVGIAFSGGLDTSAALTWMRQKGAIPYAYTANLGQPDEPDYDAIPKKA 60 M ILQ VPV QKVGIAFSGGLDTSAAL WM+ KGA+PYAYTANLGQPDE DYDAIP+KA Sbjct: 1 METILQHVPVGQKVGIAFSGGLDTSAALRWMKNKGALPYAYTANLGQPDEEDYDAIPRKA 60 Query: 61 MQYGAQQARLIDCREQLANEGIAALQSGAFHISTAGITYFNTTPLGRAVTGTMLVSAMRE 120 ++YGA++ARLIDCR QLANEGIAA+Q+GAFHIST GITYFNTTPLGRAVTGTMLV+AM+E Sbjct: 61 LEYGAEKARLIDCRPQLANEGIAAIQAGAFHISTGGITYFNTTPLGRAVTGTMLVAAMKE 120 Query: 121 DNVDIWGDGSTYKGNDIERFYRYGLLVNPNLKIYKPWLDSTFIDELGGRKEMSEFMIKSG 180 D+V IWGDGST+KGNDIERFYRYGLL NP LKIYKPWLD TFIDELGGR EMS FM K G Sbjct: 121 DDVHIWGDGSTFKGNDIERFYRYGLLTNPALKIYKPWLDQTFIDELGGRAEMSAFMTKEG 180 Query: 181 FDYKMSVEKAYSTDSNMLGATHEAKDLEFLNSGIKIVQPIMGVAFWRDDVEVKAETVTVR 240 F YKMS EKAYSTDSNMLGATHEAKDLE LNSGI+IV PIMGVAFW+ +VEVKAE V++ Sbjct: 181 FGYKMSAEKAYSTDSNMLGATHEAKDLEHLNSGIRIVNPIMGVAFWKPEVEVKAEEVSIT 240 Query: 241 FEEGRPVALNGKTFASMTELILEANRIGGRHGLGMSDQIENRIIEAKSRGIYEAPGLALL 300 F+EGRPVA+NG+ A E+ LE NRIGGRHGLGMSDQIENRIIEAKSRGIYEAPG+ALL Sbjct: 241 FDEGRPVAVNGREIADPVEMFLELNRIGGRHGLGMSDQIENRIIEAKSRGIYEAPGMALL 300 Query: 301 FIAYERLVTGIHNEDTIEQYRDNGRKLGRLLYQGRWFDSQAIMLRETXPRPLVRFAGHHA 360 IAYERLVTGIHNEDTIEQYR NG +LGRLLYQGRWFD QAIMLRET R + R Sbjct: 301 HIAYERLVTGIHNEDTIEQYRINGLRLGRLLYQGRWFDPQAIMLRETAQRWVAR------ 354 Query: 361 AITGEVTVELRRGNDYSILNTESPNLTYHPERLTMEKGEGS-FSAIDRIGQLTMRNLDIA 419 A+TG VT+ELRRGNDYSILNTESPNLTY PERL+MEK E + FS DRIGQLTMRNLD+ Sbjct: 355 AVTGTVTLELRRGNDYSILNTESPNLTYAPERLSMEKVEDAPFSPADRIGQLTMRNLDLM 414 Query: 420 DTRQKLAIYQNTGLLESSTAVSLPLLGKDEK 450 DTR KLAIY GLL T+ +LP LG D+K Sbjct: 415 DTRDKLAIYSKAGLLSLGTSSALPQLGGDKK 445 >YPO1570 [E] COG0137 Argininosuccinate synthase Ype Yersinia pestis Length = 455 Score = 716 bits (1848), Expect = 0.0, Method: Compositional matrix adjust. Identities = 346/443 (78%), Positives = 383/443 (86%), Gaps = 6/443 (1%) Query: 1 MSNILQSVPVNQKVGIAFSGGLDTSAALTWMRQKGAIPYAYTANLGQPDEPDYDAIPKKA 60 M+ IL+ +P+NQ+VGIAFSGGLDTSAAL WM++KGAIPYAYTANLGQPDE DY+AIP+KA Sbjct: 1 MTTILKHLPINQRVGIAFSGGLDTSAALLWMQKKGAIPYAYTANLGQPDEEDYEAIPRKA 60 Query: 61 MQYGAQQARLIDCREQLANEGIAALQSGAFHISTAGITYFNTTPLGRAVTGTMLVSAMRE 120 M+YGA++ARLIDCR+QL EGIAA+Q GAFH +TAG+TYFNTTPLGRAVTGTMLV+AM+E Sbjct: 61 MEYGAEKARLIDCRKQLVAEGIAAIQCGAFHNTTAGVTYFNTTPLGRAVTGTMLVAAMKE 120 Query: 121 DNVDIWGDGSTYKGNDIERFYRYGLLVNPNLKIYKPWLDSTFIDELGGRKEMSEFMIKSG 180 D+V+IWGDGSTYKGNDIERFYRYGLL N LKIYKPWLD+ FIDELGGR EMSEFMI+SG Sbjct: 121 DDVNIWGDGSTYKGNDIERFYRYGLLTNAELKIYKPWLDTDFIDELGGRHEMSEFMIQSG 180 Query: 181 FDYKMSVEKAYSTDSNMLGATHEAKDLEFLNSGIKIVQPIMGVAFWRDDVEVKAETVTVR 240 FDYKMS EKAYSTDSNMLGATHEAKDLEFLNS +KIV PIMGV FW ++V VKAE VTVR Sbjct: 181 FDYKMSTEKAYSTDSNMLGATHEAKDLEFLNSSVKIVNPIMGVKFWDENVVVKAEEVTVR 240 Query: 241 FEEGRPVALNGKTFASMTELILEANRIGGRHGLGMSDQIENRIIEAKSRGIYEAPGLALL 300 FE G PVALNG F EL++EANRIGGRHGLGMSDQIENRIIEAKSRGIYEAPG+ALL Sbjct: 241 FERGYPVALNGVVFDDSVELMMEANRIGGRHGLGMSDQIENRIIEAKSRGIYEAPGMALL 300 Query: 301 FIAYERLVTGIHNEDTIEQYRDNGRKLGRLLYQGRWFDSQAIMLRETXPRPLVRFAGHHA 360 IAYERL+TGIHNEDTIEQY NGR LGRLLYQGRWFD QA+MLR++ R + + Sbjct: 301 HIAYERLLTGIHNEDTIEQYHANGRVLGRLLYQGRWFDPQALMLRDSIQRWVA------S 354 Query: 361 AITGEVTVELRRGNDYSILNTESPNLTYHPERLTMEKGEGSFSAIDRIGQLTMRNLDIAD 420 ITGEVT+ELRRGNDYSILNT S NLTY PERLTMEKG+ FS DRIGQLTMRNLDI D Sbjct: 355 EITGEVTLELRRGNDYSILNTVSDNLTYKPERLTMEKGDSVFSPDDRIGQLTMRNLDITD 414 Query: 421 TRQKLAIYQNTGLLESSTAVSLP 443 TR+KL Y TGLL SS A LP Sbjct: 415 TREKLFNYVETGLLTSSAATGLP 437