BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0032.0039.p (485 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc2324 [GEPR] COG0477 Permeases of the major facilitator superf... 271 2e-72 Rv1634 [GEPR] COG0477 Permeases of the major facilitator superfa... 212 1e-54 MT1670 [GEPR] COG0477 Permeases of the major facilitator superfa... 212 1e-54 SMc01217 [GEPR] COG0477 Permeases of the major facilitator super... 165 2e-40 CC3078 [GEPR] COG0477 Permeases of the major facilitator superfa... 158 2e-38 >RSc2324 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 475 Score = 271 bits (694), Expect = 2e-72, Method: Compositional matrix adjust. Identities = 194/460 (42%), Positives = 277/460 (60%), Gaps = 7/460 (1%) Query: 19 ASVASWGELLGRRHGWCAVALTGGVAMHAINVHIVTTILPSVVRDIGGLDYYAWNVTLFV 78 A ASW +L + + L GVA+HAIN+++ TTILPSVV DIGG+ +YAWN TLF+ Sbjct: 8 ADDASWLDLFRGANALRVLVLAAGVALHAINLYLTTTILPSVVDDIGGVAFYAWNTTLFI 67 Query: 79 VTSIIGSTLTGKLLARLGARAAYLLALAVFGAGALVCAGAGSMGWMLAGRAVQGVGGGLL 138 V SI G+ + +++ LG R AYLL VFG G+ +CA A M +L GR +QG+GGG+L Sbjct: 68 VASITGAAVAAQVIQHLGPRGAYLLGAMVFGGGSALCALAPIMQVLLVGRVLQGLGGGVL 127 Query: 139 ASLGYALIPLVFEQRLWSRAIALVSGMWGVSTLLGPAVGGLFAAGGHWRLAFFALLPLLL 198 S Y L+ V + LW RA+AL+SGMWG++TLLGPAVGG+FA WRLAF++L+ L+ Sbjct: 128 LSAPYVLMRSVLPEPLWPRALALLSGMWGIATLLGPAVGGIFAQYATWRLAFWSLVVLIA 187 Query: 199 LQSVLVVRQLGPGRVRAQSDAVQAMPLGRIFLLALSVLLVALAAQTGLAWSALACVLGGA 258 L + V L Q++ +P ++ LLA++V+ + A+ + W ++ A Sbjct: 188 LAAAAAVVVL--KPAAPQAERPTPVPTRQLVLLAVAVVAASWASVSDSPWLGALGLIAAA 245 Query: 259 GLGAWVARIDLRHRISLLPRDGYRLSTVMGCVFACISLL-VLASCVEIFVPYFLQSLHGY 317 + R+++R +LP D Y T + ++ +LL V +C EIFVP FLQ LHG Sbjct: 246 LTLLAIRRVEMRSSRRILPADAYTGRTALAALYGVSALLAVTVTCTEIFVPLFLQRLHGQ 305 Query: 318 APLAAGYATAAMAGGWSVGSLVGSGRSAQAAARMIRMGPWLMLLGLLALAALLPASLLAA 377 +PL AGY A + GW++G+++ + A + R IR+ PW LGLL LA L+P A Sbjct: 306 SPLIAGYIAATASAGWTLGAILSAALRAASVTRAIRLAPWACALGLLVLAMLVPIG--AG 363 Query: 378 GVVADVLVVLALAAAGLGIGVGWPHLVARAMQAARPGEENLTSSAITTVQLYAMAMGAAL 437 L+++AL GLG+GV WPHL R M AA + + S++I TVQL A A+GAAL Sbjct: 364 SAWMTTLIIVALTLVGLGVGVVWPHLGNRIMTAAPAEDHDRASASIVTVQLVATALGAAL 423 Query: 438 AGLIANQAGLGMPGGVDGARQAAGVLFAVFAVAPALAIML 477 G++ N G P GA A+ LF +FAVAP A+++ Sbjct: 424 GGVVLNTLGAAGPAPDLGA--ASRWLFLLFAVAPVGALVI 461 >Rv1634 [GEPR] COG0477 Permeases of the major facilitator superfamily Mtu Mycobacterium tuberculosis H37Rv Length = 471 Score = 212 bits (540), Expect = 1e-54, Method: Compositional matrix adjust. Identities = 183/469 (39%), Positives = 262/469 (55%), Gaps = 11/469 (2%) Query: 19 ASVASWGELLGRRHGWCAVALTGGVAMHAINVHIVTTILPSVVRDIGGLDYYAWNVTLFV 78 + SW ELL R G ++ L GGVA++A N + ++LPS + DIGG YAW TL++ Sbjct: 6 SETGSWRELLSRYLG-TSIVLAGGVALYATNEFLTISLLPSTIADIGGSRLYAWVTTLYL 64 Query: 79 VTSIIGSTLTGKLLARLGARAAYLLALAVFGAGALVCAGAGSMGWMLAGRAVQGVGGGLL 138 V S++ +T +L R+GAR++YL+ LAVFG +LVCA A SM ++AGR +QG+ GGLL Sbjct: 65 VGSVVAATTVNTMLLRVGARSSYLMGLAVFGLASLVCAAAPSMQILVAGRTLQGIAGGLL 124 Query: 139 ASLGYALIPLVFEQRLWSRAIALVSGMWGVSTLLGPAVGGLFAAGGHWRLAFFALLPLLL 198 A LGYALI + LW+R ALVS MWGV+TL+GPA GGLFA G WR AF + L Sbjct: 125 AGLGYALINSTLPKSLWTRGSALVSAMWGVATLIGPATGGLFAQLGLWRWAFGVMTLLTA 184 Query: 199 LQSVLVVRQLGPGRVRAQSD----AVQAMPLGRIFLLALSVLLVALAAQTGLAWSALACV 254 L ++LV LG G V + + +P+ + L+ + L +++AA + Sbjct: 185 LMAMLVPVALGAGGVGPGGETPVGSTHKVPVWSLLLMGAAALAISVAALPNYLVQTAGLL 244 Query: 255 LGGAGLGAWVARIDLRHRISLLPRDGYRLSTVMGCVFACISLLVLASCVEIFVPYFLQSL 314 A L A +D R ++LP + S + ++ +S+ ++A+ V+ +VP F Q L Sbjct: 245 AAAALLVAVFVVVDWRIHAAVLPPSVFG-SGPLKWIYLTMSVQMIAAMVDTYVPLFGQRL 303 Query: 315 HGYAPLAAGYATAAMAGGWSVGSLVGSG-RSAQAAARMIRMGPWLMLLGLLALAALLPAS 373 P+AAG+ AA+A GW+VG + + SA+ ++ P +M G LAL A+ + Sbjct: 304 GHLTPVAAGFLGAALAVGWTVGEVASASLNSARVIGHVVAAAPLVMASG-LALGAVTQRA 362 Query: 374 LLAAGVVADVLVVLALAAAGLGIGVGWPHLVARAMQA-ARPGEENLTSSAITTVQLYAMA 432 G++A L LAL G GIG+ WPHL RAM + A P E + ++AI VQL + A Sbjct: 363 DAPVGIIA--LWALALLIIGTGIGIAWPHLTVRAMDSVADPAESSAAAAAINVVQLISGA 420 Query: 433 MGAALAGLIANQAGLGMPGGVDGARQAAGVLFAVFAVAPALAIMLTRRL 481 GA LAG++ N A G G A VL A +A A RRL Sbjct: 421 FGAGLAGVVVNTAKGGEVAAARGLYMAFTVLAAAGVIASYQATHRDRRL 469 >MT1670 [GEPR] COG0477 Permeases of the major facilitator superfamily MtC Mycobacterium tuberculosis CDC1551 Length = 471 Score = 212 bits (540), Expect = 1e-54, Method: Compositional matrix adjust. Identities = 183/469 (39%), Positives = 262/469 (55%), Gaps = 11/469 (2%) Query: 19 ASVASWGELLGRRHGWCAVALTGGVAMHAINVHIVTTILPSVVRDIGGLDYYAWNVTLFV 78 + SW ELL R G ++ L GGVA++A N + ++LPS + DIGG YAW TL++ Sbjct: 6 SETGSWRELLSRYLG-TSIVLAGGVALYATNEFLTISLLPSTIADIGGSRLYAWVTTLYL 64 Query: 79 VTSIIGSTLTGKLLARLGARAAYLLALAVFGAGALVCAGAGSMGWMLAGRAVQGVGGGLL 138 V S++ +T +L R+GAR++YL+ LAVFG +LVCA A SM ++AGR +QG+ GGLL Sbjct: 65 VGSVVAATTVNTMLLRVGARSSYLMGLAVFGLASLVCAAAPSMQILVAGRTLQGIAGGLL 124 Query: 139 ASLGYALIPLVFEQRLWSRAIALVSGMWGVSTLLGPAVGGLFAAGGHWRLAFFALLPLLL 198 A LGYALI + LW+R ALVS MWGV+TL+GPA GGLFA G WR AF + L Sbjct: 125 AGLGYALINSTLPKSLWTRGSALVSAMWGVATLIGPATGGLFAQLGLWRWAFGVMTLLTA 184 Query: 199 LQSVLVVRQLGPGRVRAQSD----AVQAMPLGRIFLLALSVLLVALAAQTGLAWSALACV 254 L ++LV LG G V + + +P+ + L+ + L +++AA + Sbjct: 185 LMAMLVPVALGAGGVGPGGETPVGSTHKVPVWSLLLMGAAALAISVAALPNYLVQTAGLL 244 Query: 255 LGGAGLGAWVARIDLRHRISLLPRDGYRLSTVMGCVFACISLLVLASCVEIFVPYFLQSL 314 A L A +D R ++LP + S + ++ +S+ ++A+ V+ +VP F Q L Sbjct: 245 AAAALLVAVFVVVDWRIHAAVLPPSVFG-SGPLKWIYLTMSVQMIAAMVDTYVPLFGQRL 303 Query: 315 HGYAPLAAGYATAAMAGGWSVGSLVGSG-RSAQAAARMIRMGPWLMLLGLLALAALLPAS 373 P+AAG+ AA+A GW+VG + + SA+ ++ P +M G LAL A+ + Sbjct: 304 GHLTPVAAGFLGAALAVGWTVGEVASASLNSARVIGHVVAAAPLVMASG-LALGAVTQRA 362 Query: 374 LLAAGVVADVLVVLALAAAGLGIGVGWPHLVARAMQA-ARPGEENLTSSAITTVQLYAMA 432 G++A L LAL G GIG+ WPHL RAM + A P E + ++AI VQL + A Sbjct: 363 DAPVGIIA--LWALALLIIGTGIGIAWPHLTVRAMDSVADPAESSAAAAAINVVQLISGA 420 Query: 433 MGAALAGLIANQAGLGMPGGVDGARQAAGVLFAVFAVAPALAIMLTRRL 481 GA LAG++ N A G G A VL A +A A RRL Sbjct: 421 FGAGLAGVVVNTAKGGEVAAARGLYMAFTVLAAAGVIASYQATHRDRRL 469 >SMc01217 [GEPR] COG0477 Permeases of the major facilitator superfamily Sme Sinorhizobium meliloti Length = 489 Score = 165 bits (417), Expect = 2e-40, Method: Compositional matrix adjust. Identities = 153/470 (32%), Positives = 226/470 (48%), Gaps = 19/470 (4%) Query: 8 PPAQRQPQLQPASVASWGELLGRRHGWCAVALTGGVAMHAINVHIVTTILPSVVRDIGGL 67 P Q + L+ S W ELL RH V L GVA+ A N V+T LP+ V + GG Sbjct: 13 PAPQTEVDLEEGS---WSELLRPRHLAATVTLCLGVALFAFNEFFVSTALPTAVAEFGGA 69 Query: 68 DYYAWNVTLFVVTSIIGSTLTGKLLARLGARAAYLLALAVFGAGALVCAGAGSMGWMLAG 127 +W TL++V +I+G L L R GAR ++A VF G + A SM +LAG Sbjct: 70 ALLSWAFTLYLVFAIVGGALAASLKVRFGARNTLIVAALVFATGTAIATMASSMPQVLAG 129 Query: 128 RAVQGVGGGLLASLGYALIPLVFEQRLWSRAIALVSGMWGVSTLLGPAVGGLFAAGGHWR 187 R +QG G G++A+L YALIP +F QRL + + +W + GP + GL WR Sbjct: 130 RVLQGFGEGIIAALCYALIPELFPQRLVPKIFGAEAIVWAAAAFGGPLISGLLTEYWSWR 189 Query: 188 LAFFALLPLLLLQSVLVVRQLGPGRVRAQSD-AVQAMPLGRIFLLALSVLLVALAAQTGL 246 AFF +P + LVV L R QS A ++PL R+ ++L++L+ Sbjct: 190 AAFFVNIPAAAIFIALVVAIL---RQPKQSPRAAGSVPLLRLVAFGFGIMLISLSNTAAD 246 Query: 247 AWSALACVLGGAGLGAWVARIDLRHRISLLPRDGYRLSTVMGCVFACISLLVLASCV-EI 305 +S A + + D R S+LP + +G + L+ LA + Sbjct: 247 GYSMSALLAAALAVFVATVHFDRRSPQSILPFGAFSFDRPLGTGLWVVLLMPLAQASGSV 306 Query: 306 FVPYFLQSLHGYAPLAAGYATAAMAGGWSVGS-LVGSGRSAQAAARMIRMGPWLMLLGLL 364 ++ Y LQ L G+ P AAG++ A MA WS+ + +V S RS + R++ W L L Sbjct: 307 YLVYALQHLWGFGPTAAGFSNALMAISWSLTAIIVASLRSHETRVRLV----WTGPLFLC 362 Query: 365 ALAALLPASLLAAGVVADVLVVLALAAAGLGIGVGWPHLVARAMQAARPGEENLTSSAIT 424 L + +A+G LV ++ +A G G G+ W L M + E + TS+ + Sbjct: 363 LGLGGLTLA-VASGEYG--LVFVSQSAVGAGFGLCWGTLSQLLMNVSSIEERDKTSALLP 419 Query: 425 TVQLYAMAMGAALAGLIANQAGLGMPGGVDGARQAAGVLFAVFAVAPALA 474 T+Q A+GAA+ G +AN G GV AR + + VFA+ LA Sbjct: 420 TLQSAGYAIGAAVFGAVANAGGFDE--GVS-ARVISAAMLGVFALGCVLA 466 >CC3078 [GEPR] COG0477 Permeases of the major facilitator superfamily Ccr Caulobacter vibrioides Length = 462 Score = 158 bits (400), Expect = 2e-38, Method: Compositional matrix adjust. Identities = 143/425 (33%), Positives = 219/425 (51%), Gaps = 30/425 (7%) Query: 42 GVAMHAINVHIVTTILPSVVRDIGGLDYYAWNVTLFVVTSIIGSTLTGKLLARLGARAAY 101 G+ ++A + + TI+PSV ++IGG Y+ W+V ++ SI+ +GKL +G RAA Sbjct: 28 GIWLNAADTLVTATIMPSVAKEIGGYQYFGWSVAAYLTGSIVAGACSGKLSIAMGLRAAT 87 Query: 102 LLALAVFGAGALVCAGAGSMGWMLAGRAVQGVGGGLLASLGYALIPLVFEQRLWSRAIAL 161 ++ V+ G + A A + GR VQG+G G + +L Y I +F Q LW R Sbjct: 88 AISGLVYAIGCAMSALAPEFITFIVGRLVQGLGAGAVVALCYVAISALFPQNLWPRVYGA 147 Query: 162 VSGMWGVSTLLGPAVGGLFAAGGHWRLAF--FALLPLLLLQSVLVVRQLGPGRVRAQSDA 219 ++G+WG +TLLGPA+GGLFAA G WR F F + ++ + +V+V+ + + Sbjct: 148 IAGVWGAATLLGPALGGLFAAVGFWRGVFWMFVVQAVIFVGAVMVMLP-----GGKREEG 202 Query: 220 VQAMPLGRIFLLALSVLLVALAAQTGLAWSALACVLGGAGLGAWVARI--DLRHRISLLP 277 +P ++ LL + V L+ A +A LA +L G+ VA + + R + LLP Sbjct: 203 GGRIPSLQLALLVIGVSLIGGAGV--VASPRLAVILAIGGMIGMVAMLAANTRTQDRLLP 260 Query: 278 RDGYRLSTVMG----CVFACISLLVLASCVEIFVPYFLQSLHGYAPLAAGYATAAMAGGW 333 + L T G +FAC + ++ ++ P F+Q+ H +PL AGY T A+A GW Sbjct: 261 KSAADLRTATGLGLLTIFACEAAVI---GFTVYGPAFIQARHDASPLLAGYVTGAIAAGW 317 Query: 334 SVGSLVGSGRSAQAAARMIRMGPWLMLLGLLALAALLPASLLAAGVVADVLVVLALAAAG 393 + +L+ A R +R+G ++ LG A+L A V LV +LA Sbjct: 318 TACALIFGHVPAHKDGRFVRLGAGVIALG---------AALSAFAVPRGNLVETSLAFVV 368 Query: 394 LGIGVGWPH-LVARAMQAARPGEEN-LTSSAITTVQLYAMAMGAALAGLIANQAGLGMPG 451 LG G G H +AR A P EE + S A+ T QL A+G+A AG +AN G G Sbjct: 369 LGAGFGLCHAFIARRTIAGAPAEEQAMASGAVPTSQLIGGAVGSAGAGAMANVLGFGHH- 427 Query: 452 GVDGA 456 G+D A Sbjct: 428 GIDAA 432