BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0029.0104.p (435 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PA4900 [GEPR] COG0477 Permeases of the major facilitator superfa... 389 e-108 RSc1093 [GEPR] COG0477 Permeases of the major facilitator superf... 272 1e-72 Cgl2967 [GEPR] COG0477 Permeases of the major facilitator superf... 241 3e-63 Cgl2357 [GEPR] COG0477 Permeases of the major facilitator superf... 233 7e-61 AGc4589 [GEPR] COG0477 Permeases of the major facilitator superf... 232 2e-60 >PA4900 [GEPR] COG0477 Permeases of the major facilitator superfamily Pae Pseudomonas aeruginosa Length = 446 Score = 389 bits (1000), Expect = e-108, Method: Compositional matrix adjust. Identities = 212/435 (48%), Positives = 294/435 (67%), Gaps = 7/435 (1%) Query: 1 MKTLDVSQIIDGARFTKFHWMVMCLCALLLVFDGYDLFIYGAVLPVLMKEWSLSPVQAGA 60 M + +ID ARF + HW+++ +++FDGYD+ IYG+V+P LM+EW LSPVQAG Sbjct: 1 MNRQSAAAVIDAARFNRTHWLILGWGCFIMLFDGYDMVIYGSVVPRLMQEWQLSPVQAGT 60 Query: 61 LGSYALFGMMFGAFIFGPLADRIGRKKGVAISFVLFSVSTFLSGFATSPTEFGVYRFLAG 120 LGS ALFGM+FG + PLADR GR++ V + +L S++ FL+G A P E G RF G Sbjct: 61 LGSCALFGMLFGGTLLAPLADRFGRRRLVIATTLLASLAAFLTGHARDPLELGAGRFFTG 120 Query: 121 LGCGGLMPNAVALMNEYAPKRLRSTLVAIMFSGYSLGGVLCAGLGIWMLPNFGWQSMFFA 180 L G L+P+A+ L++E+AP RSTLV +M + YS+G VL A L I M+P +GWQS+F+ Sbjct: 121 LALGALVPSAINLISEFAPAGRRSTLVTVMSAFYSVGAVLSALLAIAMIPAWGWQSVFYV 180 Query: 181 AAVPLVLLPVILWKLPESVGFLLRQGRLEQARAMLTQVDPQARIATDTQLVQADVKGAGA 240 A +P++ +P++L LPES FL +GR + A+L +VDP R + +A+ A A Sbjct: 181 AVLPVLAVPLMLRWLPESAAFLELKGRRAELDALLRKVDPDYRPGAE----RANAVAAEA 236 Query: 241 P---MLHLFKQDRAVGTLMIWVSFFCCLLMVYALGSWLPKLMASAGYSLGSSLSFLLALN 297 P + LF+ +AVGTL++WV+F C+LM Y L +WLPKLMA GY+LGSSL+FL+ LN Sbjct: 237 PSGRVAQLFEGRQAVGTLLLWVAFAMCMLMSYGLNTWLPKLMAGGGYALGSSLAFLVTLN 296 Query: 298 FGGVVGAIGGGWLGDRFTLPKVVVSFFTVGTVAIALLGFNSPTPVLYLLIIVAGATTIGT 357 G +GA+ GGWL DR + +V FF + ++A LG +L L++VAGATTIGT Sbjct: 297 VGATLGALFGGWLADRLGAGRTLVLFFALAAASLAALGLGPGPWLLNGLLVVAGATTIGT 356 Query: 358 QILLYANTAQFYPLAIRSTGLGWASGVGRSGAIVGPLLGGALMAAALPLKMNFLVFAIPG 417 +++A AQFYP +RSTG+GWA+GVGR GAI GP+LGG+L+A LP + NFL FA PG Sbjct: 357 LAVIHAYAAQFYPAWVRSTGVGWAAGVGRLGAIAGPMLGGSLLALELPFQQNFLAFAAPG 416 Query: 418 LVAALAMGLFMLRYR 432 ++ ALA+ LR R Sbjct: 417 VIGALAIACIHLRPR 431 >RSc1093 [GEPR] COG0477 Permeases of the major facilitator superfamily Rso Ralstonia solanacearum Length = 454 Score = 272 bits (695), Expect = 1e-72, Method: Compositional matrix adjust. Identities = 164/425 (38%), Positives = 244/425 (57%), Gaps = 5/425 (1%) Query: 4 LDVSQIIDGARFTKFHWMVMCLCALLLVFDGYDLFIYGAVLPVLMKEWSLSPVQAGALGS 63 +DV +D RF+ F W V+ LC ++ DG+D G + P L ++W + P G + S Sbjct: 8 IDVRAWLDRQRFSAFQWSVVLLCFFVVAIDGFDTACVGFIAPALAQDWHIGPAVLGTVFS 67 Query: 64 YALFGMMFGAFIFGPLADRIGRKKGVAISFVLFSVSTFLSGFATSPTEFGVYRFLAGLGC 123 L G+M GA IFGPLADRIGRK+ + + F +++ LS FA S RFL GLG Sbjct: 68 AGLAGLMVGALIFGPLADRIGRKQTLLFTVGAFGLASVLSAFAPSVGALVALRFLTGLGL 127 Query: 124 GGLMPNAVALMNEYAPKRLRSTLVAIMFSGYSLGGVLCAGLGIWMLPNFGWQS-MFFAAA 182 GG MPNA+AL +EY P+R R+ L +MF G++LG + ++P FGW+S + F Sbjct: 128 GGAMPNAIALTSEYCPERRRAFLTTVMFCGFTLGSGFGGIVAAQLVPEFGWRSVLLFGGV 187 Query: 183 VPLVLLPVILWKLPESVGFLLRQGRLEQARAMLTQVDPQARIATDTQLV--QADVKGA-G 239 +PL+LLPV+++ LPESV +L+ +G A L ++ DT+ V + KGA G Sbjct: 188 IPLLLLPVMVFALPESVRYLVAKGGQSAAVGRLLNRIAPVQVTPDTRFVLHETAAKGAPG 247 Query: 240 APMLHLFKQDRAVGTLMIWVSFFCCLLMVYALGSWLPKLMASAGYSLGSSLSFLLALNFG 299 +P+ LF GTL++W FF LL+VY + +WLP L+ S G +L + + G Sbjct: 248 SPVRQLFLPAFRTGTLLLWSVFFMSLLIVYLMTNWLPTLIHSGGVALALASRIAVMYQLG 307 Query: 300 GVVGAIGGGWLGDRFTLPKVVVSFFTVGTVAIALLGFNSPTPVLYLLIIVAGATTIGTQI 359 G VGA+ G + DR+ V+ + +G + L G + T +L + + G G+QI Sbjct: 308 GTVGALVIGRMMDRYPATVVLCCTYGLGAGFLVLTGVSQGT-MLAIAVTGVGFCISGSQI 366 Query: 360 LLYANTAQFYPLAIRSTGLGWASGVGRSGAIVGPLLGGALMAAALPLKMNFLVFAIPGLV 419 A AQFYP A R TG+ WA G+GR G++ G L+GG L+AA + ++ FL+ A+P + Sbjct: 367 GANAFAAQFYPTASRVTGISWALGIGRLGSVCGALIGGVLLAANIGFQLLFLLVAVPAAI 426 Query: 420 AALAM 424 A+LA+ Sbjct: 427 ASLAI 431 >Cgl2967 [GEPR] COG0477 Permeases of the major facilitator superfamily Cgl Corynebacterium glutamicum Length = 444 Score = 241 bits (615), Expect = 3e-63, Method: Compositional matrix adjust. Identities = 161/420 (38%), Positives = 226/420 (53%), Gaps = 38/420 (9%) Query: 5 DVSQIIDGARFTKFHWMVMCLCALLL-----VFDGYDLFIYGAVLPVLMKEWSLSPVQAG 59 + SQ I+ T L A+L+ +FDGYDL +YG V L KEW+LS G Sbjct: 21 NSSQTIENKGLTILGISGRRLAAVLIGWFFVIFDGYDLIVYGTVQSALAKEWNLSSATLG 80 Query: 60 ALGSYALFGMMFGAFIFGPLADRIGRKKGVAISFVLFSVSTFLSGFATSPTEFGVYRFLA 119 +GS A FGM GA G L+DR+GRK V S ++ SV T L FA +P FG +RF+A Sbjct: 81 TIGSTAFFGMAIGAVFIGRLSDRVGRKAAVIGSVLILSVFTMLCAFAPNPWVFGAFRFIA 140 Query: 120 GLGCGGLMPNAVALMNEYAPKRLRSTLVAIMFSGYSLGGVLCAGLGIWMLPN---FGWQS 176 GLG GGL+P+ A+ ++ P++ S +M SG +GG + A L + ++P+ +GW+ Sbjct: 141 GLGLGGLVPSVNAMTSDLVPRKTMSAWATVMMSGVPIGGSIAAVLALVVVPSSEEWGWRF 200 Query: 177 MFFAAAVPLVL-LPVILWKLPESVGFLLRQGRLEQARAMLTQVDPQARIATDTQLVQADV 235 MF A +PLV+ LP+ + +P I D + + Sbjct: 201 MFLIALIPLVVGLPIAMKVIPS-----------------------DKAIKADHDIREGHD 237 Query: 236 KGAGAPMLHLFKQDRAVGTLMIWVSF--FCCLLMVYALGSWLPKLMASAGYSLGSSLSFL 293 + AG L L + R + IW + F LL Y LG+WLP+LM +AGY G +L F Sbjct: 238 EPAGFKDL-LVDRYRWIS---IWFALATFVTLLAWYGLGTWLPRLMETAGYEFGHALMFT 293 Query: 294 LALNFGGVVGAIGGGWLGDRFTLPKVVVSFFTVGTVAIALLGFNSPTPVLYLLIIVAGAT 353 LALN G V+G++ W GDRF + V + +A+ LL P +Y+++I+AG Sbjct: 294 LALNLGAVIGSVVTAWAGDRFGPIRSGVIAAGIAGIALLLLLTYPPVTAVYVILILAGVG 353 Query: 354 TIGTQILLYANTAQFYPLAIRSTGLGWASGVGRSGAIVGPLLGGALMAAALPLKMNFLVF 413 T GTQIL+ A A FYP +R T LGWA GVGR GA+V P L G L+A L + NF++F Sbjct: 354 THGTQILIIAAVANFYPSNLRGTALGWALGVGRIGAVVAPQLAGLLLAWNLGVNSNFIMF 413 >Cgl2357 [GEPR] COG0477 Permeases of the major facilitator superfamily Cgl Corynebacterium glutamicum Length = 446 Score = 233 bits (594), Expect = 7e-61, Method: Compositional matrix adjust. Identities = 150/404 (37%), Positives = 220/404 (54%), Gaps = 12/404 (2%) Query: 7 SQIIDGARFTKFH---WMVMCLCALLLVFDGYDLFIYGAVLPVLMKE----WSLSPVQAG 59 SQI G + K +MV+ + + ++FDGYDL IYGAVL L+++ +LSP AG Sbjct: 3 SQISGGWQSAKHRTTVYMVLVVVGISILFDGYDLVIYGAVLSTLLEDPTQIGALSPAVAG 62 Query: 60 ALGSYALFGMMFGAFIFGPLADRIGRKKGVAISFVLFSVSTFLSGFATSPTEFGVYRFLA 119 LGSYA+ G+M GA G + DR+GR+K + + V FSV L+ FA+S FG RFL Sbjct: 63 TLGSYAMIGVMIGALSAGAVGDRLGRRKVMLTAIVWFSVGMALTAFASSIALFGFLRFLT 122 Query: 120 GLGCGGLMPNAVALMNEYAPKRLRSTLVAIMFSGYSLGGVLCAGLGIWMLPNFGWQSMFF 179 GLG G ++ A++ E+AP R+ AI++SG GGVL + L + GW+ +F Sbjct: 123 GLGVGMIVATGGAIIAEFAPANRRNLFNAIVYSGVPAGGVLASILALLFEDVIGWRGLFL 182 Query: 180 AAAVPLV-LLPVILWKLPESVGFLLRQGRLEQARAMLTQVDPQARIATDTQLVQADVKGA 238 PL+ LLP+ + LPES +L +GR A+A+ + + T+ +V+ + Sbjct: 183 IGGSPLLFLLPLAYFFLPESPRWLTSRGRAADAKALCARYG----LPTEEFVVEKQQETK 238 Query: 239 GAPMLHLFKQDRAVGTLMIWVSFFCCLLMVYALGSWLPKLMASAGYSLGSSLSFLLALNF 298 G +F +GT++I F LL Y L +WLPK+M S G + SL LL LN Sbjct: 239 GTGFAGIFSSKYLMGTILIGAMSFIGLLSTYGLNTWLPKIMESNGATSHDSLYSLLFLNG 298 Query: 299 GGVVGAIGGGWLGDRFTLPKVVVSFFTVGTVAIALLGFNSPTPVLYLLIIVAGATTIGTQ 358 G V G + W DR V+ S F + + + +L S P++Y I AG +GTQ Sbjct: 299 GAVFGGLIASWFADRIGAKTVITSTFALAAICLGVLPNISSWPMMYTAIAFAGVGVLGTQ 358 Query: 359 ILLYANTAQFYPLAIRSTGLGWASGVGRSGAIVGPLLGGALMAA 402 +L Y T+ F+ R+ G+ W +G GR G IVGP +GG ++ A Sbjct: 359 VLTYGLTSNFFGTECRAAGVAWCAGFGRLGGIVGPAIGGLIIGA 402 >AGc4589 [GEPR] COG0477 Permeases of the major facilitator superfamily Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 477 Score = 232 bits (591), Expect = 2e-60, Method: Compositional matrix adjust. Identities = 159/419 (37%), Positives = 233/419 (55%), Gaps = 12/419 (2%) Query: 16 TKFHWMVMCLCALLLVFDGYDLFIYGAVLPVLMKE--WSLSPVQAGALGSYALFGMMFGA 73 TK V+ C L+++FDGYDL +YGAV P L+KE W+L+P G + L GM+ GA Sbjct: 62 TKNPAGVIATCGLMIMFDGYDLVVYGAVAPALLKESTWALNPAMVGRAAALTLVGMLLGA 121 Query: 74 FIFGPLADRIGRKKGVAISFVLFSVSTFLSGFATSPTEFGVYRFLAGLGCGGLMPNAVAL 133 G +ADRIGR+K V +S FS S + F + RF AGLG G L+P AL Sbjct: 122 LFAGTMADRIGRRKVVLLSLAGFSAMMIASAMTPNFLAFEITRFFAGLGLGALLPTVTAL 181 Query: 134 MNEYAPKRLRSTLVAIMFSGYSLGGVLCAGLGIWMLPNFGWQSMFFAAAVPLVLLPVILW 193 + E++P + R+ ++ F GY +GG++ LG+ +L ++GW+ + +PL+LLP+ + Sbjct: 182 VLEFSPPQRRAQANSLSFLGYLIGGIISGILGMLLLESYGWRPLMLIGGLPLILLPIFMR 241 Query: 194 KLPESVGFLLRQGRLEQARAMLTQVDPQARIATDTQLVQADVKGAGAPMLHLFKQDRAVG 253 LPES +L +GR +A + Q RI ++ + G GA LF + R Sbjct: 242 FLPESPEWLASKGRQAEADGICDSYGLQ-RIVPHAKMQKG---GVGA----LFSEGRLAS 293 Query: 254 TLMIWVSFFCCLLMVYALGSWLPKLMASAGYSLGSSLSFLLALNFGGVVGAIGGGWLGDR 313 TL W FC LL+ + + +WLP +M GY + S+LSF + LN G +G + GG D+ Sbjct: 294 TLNAWGIHFCSLLLTFGMVNWLPTIMNKMGYDISSALSFSVMLNVGAAIGILIGGRFADK 353 Query: 314 FTLPKVVVSFFTVGTVAIALLGFNSPTPVLYLLIIVAGATTIGTQILLYANTAQFYPLAI 373 + VV F VG +I L N P+LY+ + +AGA TIGTQIL + YP+ I Sbjct: 354 GNVKVVVAILFAVGAASIFALTANK-GPLLYVFVALAGAGTIGTQILANVLVGRLYPVHI 412 Query: 374 RSTGLGWASGVGRSGAIVGPLLGGALMAAALPLKMNFLVFAIPGLVAALAMGLFMLRYR 432 R TGLG++ VGR G I GP++GG ++ L + NF +F +V L + + L YR Sbjct: 413 RGTGLGFSLAVGRLGGIAGPMIGGLVLQRGLAPEWNFYIFGSVAVV-GLMLTVLTLLYR 470