BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0029.0073.p (407 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value PA1286 [GEPR] COG0477 Permeases of the major facilitator superfa... 290 4e-78 SMc02603 [GEPR] COG0477 Permeases of the major facilitator super... 262 1e-69 AGc1918 [GEPR] COG0477 Permeases of the major facilitator superf... 259 6e-69 NMA0047 [GEPR] COG0477 Permeases of the major facilitator superf... 227 4e-59 AGl3235 [GEPR] COG0477 Permeases of the major facilitator superf... 105 2e-22 >PA1286 [GEPR] COG0477 Permeases of the major facilitator superfamily Pae Pseudomonas aeruginosa Length = 399 Score = 290 bits (742), Expect = 4e-78, Method: Compositional matrix adjust. Identities = 190/388 (48%), Positives = 249/388 (64%), Gaps = 5/388 (1%) Query: 8 RKPWLVVLAGAAIMSMALGSRQTFGLFISPLSYDHGLPVTLVAFAIALHNLVWGVAQPLA 67 R + ++L+GA I++++LG R FGLF++P+S D G + AFAIAL NLVWG+AQP Sbjct: 3 RAAFWILLSGALILALSLGVRHGFGLFLAPMSADFGWGREVFAFAIALQNLVWGLAQPFT 62 Query: 68 GALTDRHGPAPVVAFGAVCYAIGLALTALAPNGAVLVLGMGVFIGVGISCTSFGVVLPAV 127 GAL DR+G A V G + YA+GL L L+ + + L L G+ IG+G+S TSF V+L AV Sbjct: 63 GALADRYGAARAVLVGGLLYALGLVLMGLSQSASGLSLSAGLLIGLGLSGTSFSVILGAV 122 Query: 128 GRSVPAERRSGAMGLVSAGGSLGQVLMLPLVQGLRATSGMSLALMVLALLVLAVAPL-GL 186 GR+VPAE+RS AMG+ SA GS GQ MLP GL G S AL+ L LLV + PL GL Sbjct: 123 GRAVPAEQRSMAMGISSAAGSFGQFAMLPGTLGLIGWLGWSSALLALGLLVALIVPLAGL 182 Query: 187 ALARTGPVAADAPRWDYSVREVIAQATAHRGYQLLTLGFFACGFQLAFIATHLPGYLELC 246 R P + S+ E + +A AH G+ LL LGFF CGFQ+ FI HLP YL Sbjct: 183 MKDRPLPPQGH----EQSLGEALREACAHSGFWLLALGFFVCGFQVVFIGVHLPAYLVDQ 238 Query: 247 HMPMGLAATALALIGLFNMAGSWACGWLGGRYRPQRVLGWLYLVRSTAIGLFFIAPKSGQ 306 H+P + T LAL+GLFN+ G++ GWLGGR+ R+L LYLVR I LF P S Sbjct: 239 HLPAQVGTTVLALVGLFNVFGTYIAGWLGGRWSKPRLLTALYLVRGVVIVLFLWLPLSVY 298 Query: 307 SVTLFAAVMGLTWLGTVPLTTGLVARLFGTAHMGTLFGVCFLSHQVGSFLGAWLGGWMLE 366 S F MGL WL TVPLT G VA LFG ++ L G+ FL HQ+G+FLG WLGG + + Sbjct: 299 SAYAFGVAMGLLWLSTVPLTNGTVATLFGVRNLSMLGGIVFLFHQLGAFLGGWLGGVVYD 358 Query: 367 VTGSYSMLWMATFVVGIVAALLHFPIEE 394 TGSY ++W + ++ ++AALL++P+ E Sbjct: 359 RTGSYDLVWQLSILLSLLAALLNWPVRE 386 >SMc02603 [GEPR] COG0477 Permeases of the major facilitator superfamily Sme Sinorhizobium meliloti Length = 412 Score = 262 bits (669), Expect = 1e-69, Method: Compositional matrix adjust. Identities = 163/386 (42%), Positives = 225/386 (58%), Gaps = 1/386 (0%) Query: 10 PWLVVLAGAAIMSMALGSRQTFGLFISPLSYDHGLPVTLVAFAIALHNLVWGVAQPLAGA 69 PWL+++AG+ I + G R G F P+ + G T A+A NL WG+ QP GA Sbjct: 18 PWLIIVAGSIIAMLTFGPRSAMGFFQLPMLAEKGWDRTTFGLAMAFQNLCWGLGQPFFGA 77 Query: 70 LTDRHGPAPVVAFGAVCYAIGLALTALAPNGAVLVLGMGVFIGVGISCTSFGVVLPAVGR 129 + D+ G V+A + YA GL L A A L +G GV +G+G++ SFG+VL A R Sbjct: 78 IADKFGTWRVLALSGLVYAAGLILMAFADAPIWLHIGGGVLVGLGVASGSFGIVLSAFAR 137 Query: 130 SVPAERRSGAMGLVSAGGSLGQVLMLPLVQGLRATSGMSLALMVLALLVLAVAPLGLALA 189 +V E+RS A G+ +A GS G L PL QGL + G S +L+ L LL+L V + L Sbjct: 138 NVAPEQRSLAFGIGTAAGSAGMFLFAPLSQGLISAYGWSDSLVYLGLLMLLVPLFAIPLR 197 Query: 190 RTGPVAADAPR-WDYSVREVIAQATAHRGYQLLTLGFFACGFQLAFIATHLPGYLELCHM 248 + + +V E + +A H+ Y LL GFF CG+Q+AFI H P Y+ + Sbjct: 198 GNASSGRQSEALFKQTVGEALKEALGHKSYLLLVSGFFVCGYQVAFITAHFPAYIGDIGI 257 Query: 249 PMGLAATALALIGLFNMAGSWACGWLGGRYRPQRVLGWLYLVRSTAIGLFFIAPKSGQSV 308 A ALALIG FN+ GS++ G +G RY L +YL RS + F + P++ SV Sbjct: 258 DARYAVIALALIGFFNIIGSFSAGIIGQRYSKPYFLALIYLARSVVVSAFLLLPQTPTSV 317 Query: 309 TLFAAVMGLTWLGTVPLTTGLVARLFGTAHMGTLFGVCFLSHQVGSFLGAWLGGWMLEVT 368 +FA VMGL WL TVP T GLVA +FGT H+G L G+ FLSHQ+GSFLG W+GG++ + Sbjct: 318 IVFAVVMGLLWLSTVPPTNGLVAIMFGTRHLGLLGGIVFLSHQIGSFLGVWMGGYLYDHF 377 Query: 369 GSYSMLWMATFVVGIVAALLHFPIEE 394 GSY +W +G+ AA++H+PIEE Sbjct: 378 GSYDPVWWVGVALGVFAAIVHWPIEE 403 >AGc1918 [GEPR] COG0477 Permeases of the major facilitator superfamily Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 414 Score = 259 bits (663), Expect = 6e-69, Method: Compositional matrix adjust. Identities = 161/400 (40%), Positives = 228/400 (57%), Gaps = 1/400 (0%) Query: 1 MRIATVNRKPWLVVLAGAAIMSMALGSRQTFGLFISPLSYDHGLPVTLVAFAIALHNLVW 60 M AT PWL++ AG+ I M G R G F P+ D G + A+AL NL W Sbjct: 11 MSQATRQTMPWLIIAAGSLIAVMTFGPRSAMGFFQLPMLADTGWDRSTFGLAMALQNLFW 70 Query: 61 GVAQPLAGALTDRHGPAPVVAFGAVCYAIGLALTALAPNGAVLVLGMGVFIGVGISCTSF 120 G+ QP GA+ D++G V+ + YA GL + + L G GV +G+GI+ SF Sbjct: 71 GLGQPFFGAIADKYGTGRVLVLSGILYAAGLVCMSFGTSPFWLHFGGGVLVGLGIAAGSF 130 Query: 121 GVVLPAVGRSVPAERRSGAMGLVSAGGSLGQVLMLPLVQGLRATSGMSLALMVLALLVLA 180 V+L A R V ++RS A G+ +A GS G L P+ QGL + G S +L+ LA +++ Sbjct: 131 SVILSAFARHVTPQQRSLAFGIGTAAGSAGMFLFAPISQGLISAYGWSDSLVWLAAMMVL 190 Query: 181 VAPLGLAL-ARTGPVAADAPRWDYSVREVIAQATAHRGYQLLTLGFFACGFQLAFIATHL 239 V L + + + ++ +V E + +A H+ Y LLT GFF CGFQ+AFI H Sbjct: 191 VPLLAWPMRGNSSSGSQSQAQFQQTVGEALKEALGHKSYLLLTTGFFVCGFQVAFITAHF 250 Query: 240 PGYLELCHMPMGLAATALALIGLFNMAGSWACGWLGGRYRPQRVLGWLYLVRSTAIGLFF 299 P YL + A A+ALIG FN+ GS A G + RY +L ++Y+ RS + F Sbjct: 251 PAYLGDIGIEPRYAVIAMALIGFFNIIGSLAAGVIAQRYSKPYLLAYIYIARSVVVTAFL 310 Query: 300 IAPKSGQSVTLFAAVMGLTWLGTVPLTTGLVARLFGTAHMGTLFGVCFLSHQVGSFLGAW 359 + P+S SV LFA+ MG+ WL TVP T LVA +FGT H+G L GV FL+HQ+GSFLG W Sbjct: 311 LLPQSPLSVILFASFMGILWLSTVPPTNALVAIMFGTRHLGMLGGVVFLTHQIGSFLGVW 370 Query: 360 LGGWMLEVTGSYSMLWMATFVVGIVAALLHFPIEEADGRR 399 LGG++ + G+Y ++W +GI AA++H+PI+E R Sbjct: 371 LGGFLYDRFGTYDIVWWLGVGMGIFAAIVHWPIQERPAPR 410 >NMA0047 [GEPR] COG0477 Permeases of the major facilitator superfamily NmA Neisseria meningitidis Z2491 Length = 405 Score = 227 bits (578), Expect = 4e-59, Method: Compositional matrix adjust. Identities = 152/399 (38%), Positives = 217/399 (54%), Gaps = 7/399 (1%) Query: 2 RIATVNRKPWLVVLAGAAIMSMALGSRQTFGLFISPLSYDHGLPVTLVAFAIALHNLVWG 61 A+ K WL + A A I+ + +G R T GLF+ P+ L + + IA+ L+WG Sbjct: 3 HTASKTPKFWLTITAAAFILLITIGMRMTLGLFVQPVVNTTELSIAQFSLIIAVFQLMWG 62 Query: 62 VAQPLAGALTDRHGPAPVVAFGAVCYAIGLALTALAPNGAVLVLGMGVFIGVGISCTSFG 121 V+QPL+GAL DR G V++ GAV + P L++ +G+ + G F Sbjct: 63 VSQPLSGALADRFGAFRVLSGGAVLLVCACLIAPNIPTYWGLMIAVGLLLAFGTGSGGFS 122 Query: 122 VVLPAVGRSVPAERRSGAMGLVSAGGSLGQVLMLPLVQGLRA--TSGMSLALMVLALLVL 179 +++ V VPA +R A GLV+AGGS GQ L PLVQGL G + V + L Sbjct: 123 IIMGQVAAQVPAHKRGLASGLVNAGGSAGQFLFAPLVQGLVVLPEVGWTGTFYVWGAIAL 182 Query: 180 AVAPLGLALARTGPVA----ADAPRWDYSVREVIAQATAHRGYQLLTLGFFACGFQLAFI 235 P+ LA A A A S+ E + A Y LL L FFACGF +AF+ Sbjct: 183 LTLPVSWWLAGGNNAAHTQHAQATH-GQSLGEAVKTAFKTPSYILLHLSFFACGFHIAFL 241 Query: 236 ATHLPGYLELCHMPMGLAATALALIGLFNMAGSWACGWLGGRYRPQRVLGWLYLVRSTAI 295 THLP + LC +P +A+T++A+IGL N+AG GW R R + VL LY R+ I Sbjct: 242 VTHLPTEVALCGLPATVASTSIAIIGLANIAGCIFSGWCTSRVRGKYVLFGLYASRAAMI 301 Query: 296 GLFFIAPKSGQSVTLFAAVMGLTWLGTVPLTTGLVARLFGTAHMGTLFGVCFLSHQVGSF 355 ++ +PK+ + +FAA +G TWL TV T + +LFGT ++ TLFG+ LSHQ+G F Sbjct: 302 LIYIFSPKTDLNFYIFAAALGFTWLATVTPTASITGKLFGTRYLATLFGLTMLSHQIGGF 361 Query: 356 LGAWLGGWMLEVTGSYSMLWMATFVVGIVAALLHFPIEE 394 LG+++GG ++ G Y +W A ++ AALL+ PI E Sbjct: 362 LGSYIGGIVITQFGDYGWMWYADALLAGTAALLNLPIRE 400 >AGl3235 [GEPR] COG0477 Permeases of the major facilitator superfamily Atu Agrobacterium tumefaciens strain C58 (Cereon) Length = 433 Score = 105 bits (262), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 101/364 (27%), Positives = 166/364 (45%), Gaps = 26/364 (7%) Query: 11 WLVVLAGAAIMSMALGSRQTFGLFISPLSYDHGLPVTLVAFAIALHNLVWGVAQPLAGAL 70 W+V + M G+ + G+ I PL + G + ++ A+A+ +++G+ P A A Sbjct: 21 WVVAVTTFLTMLATAGAMGSAGVMIQPLHQEFGWDIADISSAMAVRLVLFGLLGPFAAAF 80 Query: 71 TDRHGPAPVVAFGAVCYAIGLALTALAPNGAVLVLGMGVFIGVGISCTSFGVVLPAVGRS 130 + G VV+ G+ + L+L GV IGVG T+ V+ V Sbjct: 81 MNHFGIRQVVSTALALIMGGIVASFFMTQVWQLLLLWGVVIGVGTGMTAL-VLGATVASR 139 Query: 131 VPAERRSGAMGLVSAGGSLGQVLMLPLVQGLRATSGMSLAL----------MVLALLVLA 180 ++RR +GL++A + GQ++ LPL+ L G AL M+L LL++ Sbjct: 140 WFSKRRGLVIGLMTASNATGQLVFLPLLAALTEAYGWRTALTLSVAVIAAAMILVLLLMR 199 Query: 181 VAPLGLALARTGPVA-ADAPRWDYSVREVIAQ-------ATAHRGYQLLTLGFFACGFQL 232 P + L G A + P+ D+++ +A + + + +L FF CG Sbjct: 200 DHPSDVGLPAYGETAVSKPPKQDHNLLATLASPLVTLKSVSGNPVFWVLFGTFFVCGLST 259 Query: 233 A-FIATHLPGYLELCH---MPMGLAATALALIGLFNMAGSWACGWLGGRYRPQRVLGWLY 288 I TH ++ +C M AA LA+IG+F+ G+ GWL R+ + +L W Y Sbjct: 260 NGLIQTH---WISICGDFGMAAVTAAGTLAVIGIFDFFGTIFAGWLSDRFDNRFLLFWFY 316 Query: 289 LVRSTAIGLFFIAPKSGQSVTLFAAVMGLTWLGTVPLTTGLVARLFGTAHMGTLFGVCFL 348 +R ++ + S +++FA GL W+ TVP T L A FG G +FG F Sbjct: 317 GLRGLSLIYLSFSGFSFVELSVFAVFYGLDWVATVPPTVKLAAENFGREKAGLVFGWVFA 376 Query: 349 SHQV 352 HQ+ Sbjct: 377 GHQL 380