BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0022.0124.p (1317 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value RSc1722_1 [F] COG0046 Phosphoribosylformylglycinamidine (FGAM) s... 1414 0.0 PA3763_1 [F] COG0046 Phosphoribosylformylglycinamidine (FGAM) sy... 1169 0.0 VC0869_1 [F] COG0046 Phosphoribosylformylglycinamidine (FGAM) sy... 1135 0.0 HI0752_1 [F] COG0046 Phosphoribosylformylglycinamidine (FGAM) sy... 1132 0.0 NMA0445_1 [F] COG0046 Phosphoribosylformylglycinamidine (FGAM) s... 1126 0.0 >RSc1722_1 [F] COG0046 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain Rso Ralstonia solanacearum Length = 1046 Score = 1414 bits (3661), Expect = 0.0, Method: Compositional matrix adjust. Identities = 701/1019 (68%), Positives = 803/1019 (78%), Gaps = 23/1019 (2%) Query: 1 VDAAITGVSGRYLHFVDAAQALTQEDEARLNGLLTYGDPFNGSDDGETFVVIPRLGTISP 60 +D I VS +YLHFV A L+ +D AR+ LLTYG P + +G+ FVVIPR GTISP Sbjct: 28 IDPEIDAVSAQYLHFVAADAPLSADDAARVQALLTYGSPASAETEGDRFVVIPRFGTISP 87 Query: 61 WASKATDIVRNCGMAHIHRVERGIIFRVQVKTGLL----GGAKKLNEASLPGVAALLHDR 116 WASKAT+I R+C + IHR+ERG+ F V K GLL GG K+L+EA+ VAA LHDR Sbjct: 88 WASKATEIARHCALPQIHRIERGVEFTVTCKKGLLRGLTGGRKQLDEATRAAVAAHLHDR 147 Query: 117 MTETVLRDPQQASALFSELQAKPLESVDVLGG----GRAALERANTELGLALSDDEIDYL 172 MTE V+ + LF L AK L VD+ G GR ALE ANTE+GLALSDDEIDYL Sbjct: 148 MTEIVVATREAGYGLFDVLPAKALRFVDLGSGDAAAGRGALEAANTEMGLALSDDEIDYL 207 Query: 173 VEAFTKAQRNPTDVELMMFAQANSEHCRHKIFNADWTIDGQKQDKSLFGMIKNTHQLAPK 232 V+A+ K RNPTDVELMMFAQANSEHCRHKIFNADWTIDG+ QDKSLF MI+NTHQLAP+ Sbjct: 208 VDAYRKLGRNPTDVELMMFAQANSEHCRHKIFNADWTIDGETQDKSLFAMIRNTHQLAPQ 267 Query: 233 GTVVAYSDNSSIIEGATVSRFYQRGAIKGNV----YEASEELTHILMKVETHNHPTAISP 288 GTVVAYSDN++++EG R++ G Y E LTH LMKVETHNHPTAISP Sbjct: 268 GTVVAYSDNAAVMEGGMAERWFPHAGTDGETGVPQYGRREALTHTLMKVETHNHPTAISP 327 Query: 289 FPGASTGAGGEIRDEGATGRGSKPKAGLTGFTVSNLMVTHAVQPWENARDVAQPVAERD- 347 FPGASTGAGGEIRDEGATGRG+KPKAGLTGFTVSNL++ AVQ WENARD AQP A+R+ Sbjct: 328 FPGASTGAGGEIRDEGATGRGAKPKAGLTGFTVSNLLLPEAVQSWENARDTAQPAAQRNP 387 Query: 348 AHAQGGIYGKPERIASPLQIMIDGPLGGAAFNNEFGRPNLGGYFRTYEQNVGGQVMGYHK 407 G GKP+RIASPLQIMI+GP+GGAAFNNEFGRPNLGGYFR YEQNVGG V GYHK Sbjct: 388 GDTAPGPVGKPDRIASPLQIMIEGPIGGAAFNNEFGRPNLGGYFRVYEQNVGGTVRGYHK 447 Query: 408 PIMIAGGMGNISAKHTKKNDLPVGSLLIQLGGPGMRIGMGGGAASSMATGVNAADLDFDS 467 PIMIAGG+GNI A HT K+ LP G+LL+QLGGPGMRIGMGGGAASSMATG N ADLDFDS Sbjct: 448 PIMIAGGIGNIDAGHTHKHGLPAGTLLVQLGGPGMRIGMGGGAASSMATGTNTADLDFDS 507 Query: 468 VQRGNPEMERRAQEVINACWALGDDNPIQSIHDVGAGGLSNAFPEITNDAKRGAIFDLRK 527 VQRGNPEM+RRAQEVINACWALG+DNPI SIHDVGAGG+SNAFPE+ + A RGA FDLR+ Sbjct: 508 VQRGNPEMQRRAQEVINACWALGEDNPILSIHDVGAGGISNAFPELVDGADRGARFDLRQ 567 Query: 528 VPLEESGLAPREIWSNESQERYVLAILPEHLELFKYLCERERAPFAVVGTATEERQLKVI 587 V LEESGL+P EIW NESQERY LAI P F+ +CERERAPF+VVG ATEE+QL+V+ Sbjct: 568 VHLEESGLSPAEIWCNESQERYTLAIAPGDFPRFQAMCERERAPFSVVGFATEEQQLQVV 627 Query: 588 DPEH-----NNSPVDMPMDVLLGKPPKMHRDVTHVEKQLPPVDLTGMDLVEVAQRVLRLP 642 D + + PV+MPMDVLLGKPP+MHRDV V + LP VD+TG+DL VA+ VLR P Sbjct: 628 DGDAPADAVEHFPVNMPMDVLLGKPPRMHRDVRRVAQALPEVDVTGLDLETVARDVLRHP 687 Query: 643 AVADKSFLITIGDRSVGAMTVRDQMVGPWQVPVADVAVTAMGLEGYRGEAMAMGERTPLA 702 VA KSFLITIGDR+VG + RDQMVGPWQVPVADVAVT + +GY GEAM MGERTPLA Sbjct: 688 TVASKSFLITIGDRTVGGLNTRDQMVGPWQVPVADVAVTTLDYKGYAGEAMTMGERTPLA 747 Query: 703 VIDAPASGRMAVGEAITNIAAAPIAEIGDIKLSANWMAACGQPGQDAALFDTVKAVGMEL 762 VIDAPASGRMA+GEAITNIAAAPIA + +KLSANWMAACG G+DA L+DTVKAVGMEL Sbjct: 748 VIDAPASGRMAIGEAITNIAAAPIASLAQLKLSANWMAACGVDGEDARLYDTVKAVGMEL 807 Query: 763 CPALGVSIPVGKDSLSMRSTWSDEEGAKSVTSPVSLIVSGFAPVTDVRRVLTPQLRK--- 819 CPALG+SIPVGKDSLSMR+ W D AK V +PVSLIVS FAPVTDVR+ LTPQL+ Sbjct: 808 CPALGISIPVGKDSLSMRTKWDDAGEAKEVVAPVSLIVSAFAPVTDVRKTLTPQLKPVAS 867 Query: 820 --DKGETVLILIDLGRGKNRMGASALTQVMQQIGNETPDVDSADDLKAFFNAIQQLNTED 877 + +T LI+IDLG GK+R+G S L QV QQIGN PDV A+DLK FF AIQQLN Sbjct: 868 AGEAADTTLIVIDLGHGKHRLGGSILAQVTQQIGNSVPDVGDAEDLKRFFAAIQQLNAAG 927 Query: 878 RLLAYHDRSDGGLYATLAEMAFAGHTGISVNLDILTMEGEHAADWGDSKNWTTQVAERRN 937 LLAYHDRSDGGL+AT+ EMAFAGH G+S+N+D+LT++G HA+D+GD+KNW QV+ RR Sbjct: 928 MLLAYHDRSDGGLWATVCEMAFAGHCGVSINVDMLTLDGAHASDYGDAKNWAQQVSGRRA 987 Query: 938 ELTLRALFSEELGAVIQVPAEQKSDVMNVLRSYNLGACSHIIGKPNDRDVIEFMRDAKN 996 ++TLRALF+EELGAVIQVPA Q+ V VLR + L ACSH+IG PN IE RDAK Sbjct: 988 DMTLRALFAEELGAVIQVPAAQRDAVFAVLREHGLAACSHVIGAPNASGQIEIWRDAKK 1046 >PA3763_1 [F] COG0046 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain Pae Pseudomonas aeruginosa Length = 976 Score = 1169 bits (3025), Expect = 0.0, Method: Compositional matrix adjust. Identities = 595/984 (60%), Positives = 708/984 (71%), Gaps = 55/984 (5%) Query: 4 AITGVSGRYLHFVDAAQALTQEDEARLNGLLTYGDPFNGSD-DGETFVVIPRLGTISPWA 62 A+TG+ + HF D ALT ++E L LL YG + G F+V+PR GTISPW+ Sbjct: 28 AVTGLYAEFAHFADVTGALTADEEQVLARLLKYGPSVPVQEPSGRLFLVVPRFGTISPWS 87 Query: 63 SKATDIVRNCGMAHIHRVERGIIFRVQVKTGLLGGAKKLNEASLPGVAALLHDRMTETVL 122 SKA+DI RNCG+A I R+ERGI + VQ +L+E+ VAA LHDRMT+ VL Sbjct: 88 SKASDIARNCGLAKIDRLERGIAYYVQ---------GELSESDAQQVAARLHDRMTQLVL 138 Query: 123 RDPQQASALFSELQAKPLESVDVLGGGRAALERANTELGLALSDDEIDYLVEAFTKAQRN 182 + A+ LFS Q +PL +VDVLGGGRAALE+AN ELGLAL++DEIDYL+++F + RN Sbjct: 139 DRLEGAAELFSHAQPRPLTAVDVLGGGRAALEKANVELGLALAEDEIDYLLKSFGELGRN 198 Query: 183 PTDVELMMFAQANSEHCRHKIFNADWTIDGQKQDKSLFGMIKNTHQLAPKGTVVAYSDNS 242 P DVELMMFAQANSEHCRHKIFNA W IDGQ QDKSLFGMIKNT+++ +G + AY DN+ Sbjct: 199 PHDVELMMFAQANSEHCRHKIFNASWDIDGQAQDKSLFGMIKNTYEMNREGVLSAYKDNA 258 Query: 243 SIIEGATVSRFYQRGAIKGNVYEASEELTHILMKVETHNHPTAISPFPGASTGAGGEIRD 302 ++I G RF+ + Y AS E ILMKVETHNHPTAI+PFPGASTG+GGEIRD Sbjct: 259 AVIVGHVAGRFFPDPQTR--EYAASREPVQILMKVETHNHPTAIAPFPGASTGSGGEIRD 316 Query: 303 EGATGRGSKPKAGLTGFTVSNLMVTHAVQPWENARDVAQPVAERDAHAQGGIYGKPERIA 362 EGATGRG+KPKAGLTGFTVSNL + QPWE YGKPERI Sbjct: 317 EGATGRGAKPKAGLTGFTVSNLQIPGFEQPWEVP------------------YGKPERIV 358 Query: 363 SPLQIMIDGPLGGAAFNNEFGRPNLGGYFRTYEQNV----GGQVMGYHKPIMIAGGMGNI 418 + L IM++GPLGGAAFNNEFGRP L GYFRT+EQ + G +V GYHKPIM+AGGMGNI Sbjct: 359 TALDIMVEGPLGGAAFNNEFGRPALTGYFRTFEQKIATPHGEEVRGYHKPIMLAGGMGNI 418 Query: 419 SAKHTKKNDLPVGSLLIQLGGPGMRIGMGGGAASSMATGVNAADLDFDSVQRGNPEMERR 478 +H +K ++ VG+ LI LGGP M IG+GGGAASSMATG ++ADLDF SVQR NPEMERR Sbjct: 419 RDEHVQKGEISVGAKLIVLGGPAMLIGLGGGAASSMATGASSADLDFASVQRDNPEMERR 478 Query: 479 AQEVINACWALGDDNPIQSIHDVGAGGLSNAFPEITNDAKRGAIFDLRKVPLEESGLAPR 538 QEVI+ CW LG+ NPI IHDVGAGGLSNA PE+ ND RG F+LR VP +E G++P Sbjct: 479 CQEVIDRCWQLGERNPISFIHDVGAGGLSNALPELINDGGRGGRFELRAVPNDEPGMSPL 538 Query: 539 EIWSNESQERYVLAILPEHLELFKYLCERERAPFAVVGTATEERQLKVIDPEHNNSPVDM 598 EIW NESQERYVL++ E FK +CERER PFAVVG A E+RQL V D +N PVDM Sbjct: 539 EIWCNESQERYVLSVDAADFETFKAICERERCPFAVVGEAIEQRQLTVADSHFDNKPVDM 598 Query: 599 PMDVLLGKPPKMHRDVTHVEKQLPPVDLTGMDLVEVAQRVLRLPAVADKSFLITIGDRSV 658 P++VLLGK P+MHR VT + D G++L E +RVLR PAVA KSFLITIGDR++ Sbjct: 599 PLEVLLGKAPRMHRAVTREAELGDDFDAAGLELQESVERVLRHPAVASKSFLITIGDRTI 658 Query: 659 GAMTVRDQMVGPWQVPVADVAVTAMGLEGYRGEAMAMGERTPLAVIDAPASGRMAVGEAI 718 + RDQMVGPWQVPVAD AVTA + Y GEAMAMGERTPLA++DAPASGRMA+GE + Sbjct: 659 TGLVARDQMVGPWQVPVADCAVTATSFDVYTGEAMAMGERTPLALLDAPASGRMAIGETV 718 Query: 719 TNIAAAPIAEIGDIKLSANWMAACGQPGQDAALFDTVKAVGMELCPALGVSIPVGKDSLS 778 TN+AAA + ++ DIKLSANWMAA G PG+DA L+DTVKAVGMELCP LG++IPVGKDS+S Sbjct: 719 TNLAAARVGKLSDIKLSANWMAAAGHPGEDARLYDTVKAVGMELCPELGITIPVGKDSMS 778 Query: 779 MRSTWSDEEGAKSVTSPVSLIVSGFAPVTDVRRVLTPQLRKDKGETVLILIDLGRGKNRM 838 M++ W D KSVTSPVSLIV+GFAPV DVR+ LTPQLR DKGET LILIDLGRGKNR+ Sbjct: 779 MKTRWQDNGEDKSVTSPVSLIVTGFAPVADVRQSLTPQLRLDKGETDLILIDLGRGKNRL 838 Query: 839 GASALTQVMQQIGNETPDVDSADDLKAFFNAIQQLNTEDRLLAYHDRSDGGLYATLAEMA 898 G S L QV ++G PDVD A+DLKAFF IQ LN + +LAYHDRSDGGL ++ EMA Sbjct: 839 GGSILAQVHGKLGRAVPDVDDAEDLKAFFAVIQGLNADGHILAYHDRSDGGLITSVLEMA 898 Query: 899 FAGHTGISVNLDILTMEGEHAADWGDSKNWTTQVAERRNELTLRALFSEELGAVIQVPAE 958 FAGH G+ +NLD L A+ R EL LFSEELGAVIQV Sbjct: 899 FAGHCGVELNLDAL--------------------ADSREELA-AVLFSEELGAVIQVREG 937 Query: 959 QKSDVMNVLRSYNLGACSHIIGKP 982 +V+ + L C +IG+P Sbjct: 938 ATPEVLAQFSAAGLDDCVAVIGQP 961 >VC0869_1 [F] COG0046 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain Vch Vibrio cholerae Length = 972 Score = 1135 bits (2937), Expect = 0.0, Method: Compositional matrix adjust. Identities = 571/991 (57%), Positives = 701/991 (70%), Gaps = 58/991 (5%) Query: 5 ITGVSGRYLHFVDAAQALTQEDEARLNGLLTYGDPFNGSD-DGETFVVIPRLGTISPWAS 63 +TG+ ++HF D L ++ +L LLTYG + G +V PR GTISPW+S Sbjct: 29 VTGIYAEFMHFADLKAELNPQELEKLEKLLTYGPTIQEHEPQGLLLLVTPRPGTISPWSS 88 Query: 64 KATDIVRNCGMAHIHRVERGIIFRVQVKTGLLGGAKKLNEASLPGVAALLHDRMTETVLR 123 KATDI NCG+ I R+ERG + V+ +T L A + + ALLHDRM E V Sbjct: 89 KATDIAHNCGLHGIKRLERGTAYYVEAETAL-------TAAQIATLEALLHDRMMEVVFA 141 Query: 124 DPQQASALFSELQAKPLESVDVLGGGRAALERANTELGLALSDDEIDYLVEAFTKAQRNP 183 + A LFS + P+ VDVL GGR ALE AN LGLAL++DEIDYLVE+FTK RNP Sbjct: 142 ELTDAQQLFSVAEPAPMSQVDVLAGGRRALEEANVSLGLALAEDEIDYLVESFTKLGRNP 201 Query: 184 TDVELMMFAQANSEHCRHKIFNADWTIDGQKQDKSLFGMIKNTHQLAPKGTVVAYSDNSS 243 D+ELMMFAQANSEHCRHKIFNADWTIDG KQDKSLF MIKNT + P + AY DN++ Sbjct: 202 NDIELMMFAQANSEHCRHKIFNADWTIDGVKQDKSLFKMIKNTFEQTPDYVLSAYKDNAA 261 Query: 244 IIEGATVSRFYQRGAIKGNVYEASEELTHILMKVETHNHPTAISPFPGASTGAGGEIRDE 303 ++ G+TV RF+ + Y E HILMKVETHNHPTAISP+PGASTG+GGEIRDE Sbjct: 262 VMTGSTVGRFFPDPESRQYTYH--HEDAHILMKVETHNHPTAISPWPGASTGSGGEIRDE 319 Query: 304 GATGRGSKPKAGLTGFTVSNLMVTHAVQPWENARDVAQPVAERDAHAQGGIYGKPERIAS 363 GATG G KPKAGL GFT SNL + QPWE+ +GKP RI + Sbjct: 320 GATGIGGKPKAGLVGFTTSNLRIPGFEQPWESD------------------FGKPSRIVN 361 Query: 364 PLQIMIDGPLGGAAFNNEFGRPNLGGYFRTYEQNV----GGQVMGYHKPIMIAGGMGNIS 419 L IM++GPLGGAAFNNEFGRPNL GYFRTYE+ V G +V GYHKPIMIAGGMGNI Sbjct: 362 ALDIMLEGPLGGAAFNNEFGRPNLLGYFRTYEEKVTSHAGEEVRGYHKPIMIAGGMGNIR 421 Query: 420 AKHTKKNDLPVGSLLIQLGGPGMRIGMGGGAASSMATGVNAADLDFDSVQRGNPEMERRA 479 A+H +K ++PVG+ LI LGGP M IG+GGGAASSMA+G +A DLDF SVQR NPEMERR Sbjct: 422 AEHIQKKEIPVGAKLIVLGGPAMNIGLGGGAASSMASGQSAEDLDFASVQRENPEMERRC 481 Query: 480 QEVINACWALGDDNPIQSIHDVGAGGLSNAFPEITNDAKRGAIFDLRKVPLEESGLAPRE 539 QEVI+ CW LGD NPI IHDVGAGG+SNA PE+ ND RG F LR VP +E G++P E Sbjct: 482 QEVIDRCWQLGDKNPIAFIHDVGAGGISNALPELVNDGDRGGKFQLRNVPNDEPGMSPLE 541 Query: 540 IWSNESQERYVLAILPEHLELFKYLCERERAPFAVVGTATEERQLKVIDPEHNNSPVDMP 599 IW NESQERYVLA+ E + LF +C+RERAP+AVVG ATEER L + D N+P+DMP Sbjct: 542 IWCNESQERYVLAVAAEDMPLFDAICQRERAPYAVVGEATEERHLTLEDSHFANTPIDMP 601 Query: 600 MDVLLGKPPKMHRDVTHVEKQLPPVDLTGMDLVEVAQRVLRLPAVADKSFLITIGDRSVG 659 MD+LLGKPPKMHR+ + ++ P ++ +G++L E RVLRLPAVA+K+FLITIGDRSV Sbjct: 602 MDILLGKPPKMHREASTLKVSSPALERSGIELNEAVDRVLRLPAVAEKTFLITIGDRSVT 661 Query: 660 AMTVRDQMVGPWQVPVADVAVTAMGLEGYRGEAMAMGERTPLAVIDAPASGRMAVGEAIT 719 + RDQMVGPWQVPVA+ AVTA + Y GEAM+MGERTP+A++D AS R+AVGEAIT Sbjct: 662 GLVARDQMVGPWQVPVANCAVTAASFDSYHGEAMSMGERTPVALLDFGASARLAVGEAIT 721 Query: 720 NIAAAPIAEIGDIKLSANWMAACGQPGQDAALFDTVKAVGMELCPALGVSIPVGKDSLSM 779 NIAA I E+ IKLSANWM+ G PG+DA L++ VKAVG ELCPALG++IPVGKDS+SM Sbjct: 722 NIAATDIGELKRIKLSANWMSPAGHPGEDAGLYEAVKAVGEELCPALGITIPVGKDSMSM 781 Query: 780 RSTWSDEEGAKSVTSPVSLIVSGFAPVTDVRRVLTPQLRKDKGETVLILIDLGRGKNRMG 839 ++ W + K VTSP+SLI++ FA V D+R+ +TPQLR D GET LILIDLG G+NR+G Sbjct: 782 KTKWQENGEQKEVTSPLSLIITAFARVEDIRKTVTPQLRTDLGETSLILIDLGNGQNRLG 841 Query: 840 ASALTQVMQQIGNETPDVDSADDLKAFFNAIQQLNTEDRLLAYHDRSDGGLYATLAEMAF 899 A+AL QV +Q+G++ DVD+A LK FF+A+Q L D+L+AYHD+ DGGL TLAEMAF Sbjct: 842 ATALAQVYKQLGDKPADVDNAAQLKGFFDAVQTLVRNDKLVAYHDKGDGGLLVTLAEMAF 901 Query: 900 AGHTGISVNLDILTMEGEHAADWGDSKNWTTQVAERRNELTLRALFSEELGAVIQVPAEQ 959 AGH GI N++ L GD L ALF+EELGAV+QV ++ Sbjct: 902 AGHCGIKANIETL----------GDD--------------ALAALFNEELGAVVQVKNDE 937 Query: 960 KSDVMNVLRSYNLGACSHIIG--KPNDRDVI 988 + V+ L ++ L AC+H+IG + +DR +I Sbjct: 938 LNAVLATLAAHGLEACAHVIGEVEASDRLLI 968 >HI0752_1 [F] COG0046 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain Hin Haemophilus influenzae Length = 1011 Score = 1132 bits (2927), Expect = 0.0, Method: Compositional matrix adjust. Identities = 567/1010 (56%), Positives = 709/1010 (70%), Gaps = 57/1010 (5%) Query: 5 ITGVSGRYLHFVDAAQALTQEDEARLNGLLTYGDPFNG-SDDGETFVVIPRLGTISPWAS 63 IT V YLHFV+ +L +++ +L LL YG F+ G +V PR+GTIS W+S Sbjct: 54 ITSVYAEYLHFVEQKTSLVEDEIVKLQALLHYGSMFSELKPAGYCLIVTPRVGTISSWSS 113 Query: 64 KATDIVRNCGMAHIHRVERGIIFRVQVKTGLLGGAKKLNEASLPGVAALLHDRMTETVLR 123 KATDI NCG++ ++R+ERGI + ++ + L EA L + LLHDRM ETVL Sbjct: 114 KATDIAHNCGLSKVNRIERGIAYYFNIE-------RDLTEAELATLKDLLHDRMLETVLN 166 Query: 124 DPQQASALFSELQAKPLESVDVLGGGRAALERANTELGLALSDDEIDYLVEAFTKAQRNP 183 +A+ LF++ + K L ++D+L GGR ALE+AN LGLAL+DDE+DYLVE+FT +RNP Sbjct: 167 HETEAALLFTQQEPKALTTIDILNGGRQALEQANIALGLALADDEMDYLVESFTALKRNP 226 Query: 184 TDVELMMFAQANSEHCRHKIFNADWTIDGQKQDKSLFGMIKNTHQLAPKGTVVAYSDNSS 243 DVEL MFAQANSEHCRHKIFNADW IDG+KQDKSLF MIKNT + P + AY DN++ Sbjct: 227 QDVELYMFAQANSEHCRHKIFNADWIIDGKKQDKSLFKMIKNTFEQTPDFVLSAYKDNAA 286 Query: 244 IIEGATVSRFYQRGAIKGNVYEASEELTHILMKVETHNHPTAISPFPGASTGAGGEIRDE 303 ++EG+ V R++ Y +E HILMKVETHNHPTAISPFPGA+TG+GGEIRDE Sbjct: 287 VMEGSKVGRWFPD---PDGQYRVHQEDVHILMKVETHNHPTAISPFPGAATGSGGEIRDE 343 Query: 304 GATGRGSKPKAGLTGFTVSNLMVTHAVQPWENARDVAQPVAERDAHAQGGIYGKPERIAS 363 GATGRG+KPKAGLTGF+VSNL++ + QPWEN P++ KP RIAS Sbjct: 344 GATGRGAKPKAGLTGFSVSNLVIPNFEQPWEN------PLS------------KPNRIAS 385 Query: 364 PLQIMIDGPLGGAAFNNEFGRPNLGGYFRTYEQNV----GGQVMGYHKPIMIAGGMGNIS 419 L IMID PLG AAFNNEFGRP L GYFRTYE+ V G +V GYHKPIM+AGG+GNI Sbjct: 386 ALDIMIDAPLGSAAFNNEFGRPALLGYFRTYEEKVNSFAGKEVRGYHKPIMLAGGIGNIR 445 Query: 420 AKHTKKNDLPVGSLLIQLGGPGMRIGMGGGAASSMATGVNAADLDFDSVQRGNPEMERRA 479 + +K ++P+G+ LI LGG M IG+GGGAASSM +G + DLDF SVQR NPEMERR Sbjct: 446 GEQVQKGEIPIGAKLIVLGGAAMNIGLGGGAASSMDSGKSKEDLDFASVQRENPEMERRC 505 Query: 480 QEVINACWALGDDNPIQSIHDVGAGGLSNAFPEITNDAKRGAIFDLRKVPLEESGLAPRE 539 QEVI+ CW LG++NPI IHDVGAGGLSNA PE+ +D KRG FDLR + +E G++P E Sbjct: 506 QEVIDRCWQLGEENPILFIHDVGAGGLSNAMPELVHDGKRGGKFDLRSILCDEKGMSPLE 565 Query: 540 IWSNESQERYVLAILPEHLELFKYLCERERAPFAVVGTATEERQLKVIDPEHNNSPVDMP 599 IW NESQERYVLA+ PE+LELF LCERERAPFAV+G AT+ L + D +N+P+D+P Sbjct: 566 IWCNESQERYVLAVAPENLELFTALCERERAPFAVIGEATQAEHLILHDSHFDNNPIDLP 625 Query: 600 MDVLLGKPPKMHRDVTHVEKQLPPVDLTGMDLVEVAQRVLRLPAVADKSFLITIGDRSVG 659 M+VLLGK PKM R+V + + + + L E RVLRLP VA+K+FLITIGDRSV Sbjct: 626 MNVLLGKTPKMTREVLSKTVENQSLKIESIQLKEAFHRVLRLPVVAEKTFLITIGDRSVT 685 Query: 660 AMTVRDQMVGPWQVPVADVAVTAMGLEGYRGEAMAMGERTPLAVIDAPASGRMAVGEAIT 719 M RDQMVGPWQ+PV+DVAVT L+ Y GEAMA+GER+P+A++D AS R+AV EAIT Sbjct: 686 GMVARDQMVGPWQIPVSDVAVTTASLDSYHGEAMAIGERSPVALLDFSASARLAVAEAIT 745 Query: 720 NIAAAPIAEIGDIKLSANWMAACGQPGQDAALFDTVKAVGMELCPALGVSIPVGKDSLSM 779 NIA I E+ IKLSANWM+A G G+DA L++ VKAVG ELCPALG++IPVGKDS+SM Sbjct: 746 NIAGTLIGEMKRIKLSANWMSAAGHTGEDAGLYEAVKAVGEELCPALGLTIPVGKDSMSM 805 Query: 780 RSTWSDEEGAKSVTSPVSLIVSGFAPVTDVRRVLTPQLRKDKGETVLILIDLGRGKNRMG 839 ++TW D KSVT+P+SL++S FA V DVR+ LTPQLR DKG + L+LIDLG G NR+G Sbjct: 806 KTTWIDNGEQKSVTAPLSLVISAFARVEDVRKTLTPQLRTDKGFSSLLLIDLGEGHNRLG 865 Query: 840 ASALTQVMQQIGNETPDVDSADDLKAFFNAIQQLNTEDRLLAYHDRSDGGLYATLAEMAF 899 A+AL QV +Q+G++ DV LK F+NA+Q L ED+LLAYHDRSDGGL TLAEMAF Sbjct: 866 ATALAQVYKQLGDKPADVVKVQRLKDFYNAMQTLVAEDKLLAYHDRSDGGLITTLAEMAF 925 Query: 900 AGHTGISVNLDILTMEGEHAADWGDSKNWTTQVAERRNELTLRALFSEELGAVIQVPAEQ 959 AGH G+ V++ L GD+ L LF+EELGAVIQV Q Sbjct: 926 AGHCGVEVDISAL----------GDND--------------LAVLFNEELGAVIQVADSQ 961 Query: 960 KSDVMNVLRSYNLGACSHIIGKPNDRDVIEFMRDAKNIYSQPRAELHRVW 1009 V VL+++NL H +G D E R + ++S+ R+EL +W Sbjct: 962 LESVREVLKAHNLLGIIHQLGTVTADDRFEISRGSHKLFSEKRSELRSIW 1011 >NMA0445_1 [F] COG0046 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain NmA Neisseria meningitidis Z2491 Length = 1001 Score = 1126 bits (2913), Expect = 0.0, Method: Compositional matrix adjust. Identities = 590/994 (59%), Positives = 712/994 (71%), Gaps = 37/994 (3%) Query: 8 VSGRYLHFVDAAQALTQEDEARLNGLL---TYGDPFNGSDDGETFVVIPRLGTISPWASK 64 +S + +FV + +AL +L LL + + F+V PRLGTISPWASK Sbjct: 35 LSSEFWYFVGSEKALDAATVEKLQALLAAQSVEQTPKAREGLHLFLVTPRLGTISPWASK 94 Query: 65 ATDIVRNCGMAHIHRVERGIIFRVQVKTGLLGGAKKLNEASLPGVAALLHDRMTETVLRD 124 AT+I NCG+A I R+ERG+ L GA L + AALLHDRMTE+VL D Sbjct: 95 ATNIAENCGLAGIERIERGMAV-------WLEGA--LTDEQQQQWAALLHDRMTESVLPD 145 Query: 125 PQQASALFSELQAKPLESVDVLGGGRAALERANTELGLALSDDEIDYLVEAFTKAQRNPT 184 Q AS LF L+++ +VDVLGGG+ AL +ANTE+GLALS DEIDYLVE + QRNP+ Sbjct: 146 FQTASKLFHHLESETFSTVDVLGGGKEALVKANTEMGLALSADEIDYLVENYQALQRNPS 205 Query: 185 DVELMMFAQANSEHCRHKIFNADWTIDGQKQDKSLFGMIKNTHQLAPKGTVVAYSDNSSI 244 DVELMMFAQANSEHCRHKIFNAD+ ++G+KQ KSLFGMI++TH P+GTVVAY DNSS+ Sbjct: 206 DVELMMFAQANSEHCRHKIFNADFILNGEKQPKSLFGMIRDTHNAHPEGTVVAYKDNSSV 265 Query: 245 IEGATVSRFYQRGAIKGNVYEASEELTHILMKVETHNHPTAISPFPGASTGAGGEIRDEG 304 IEGA V RFY A + Y EE THI+MKVETHNHPTAI+PF GA+TGAGGEIRDEG Sbjct: 266 IEGAKVERFYPNAA-ENQGYRFHEEDTHIIMKVETHNHPTAIAPFAGAATGAGGEIRDEG 324 Query: 305 ATGRGSKPKAGLTGFTVSNLMVTHAVQPWENARDVAQPVAERDAHAQGGIYGKPERIASP 364 ATG+GS+PKAGLTGFTVSNL + QPWE YGKPE I+SP Sbjct: 325 ATGKGSRPKAGLTGFTVSNLNIPGLKQPWEQD------------------YGKPEHISSP 366 Query: 365 LQIMIDGPLGGAAFNNEFGRPNLGGYFRTYEQNVGGQVMGYHKPIMIAGGMGNISAKHTK 424 L IMI+GP+GGAAFNNEFGRPNL GYFRT+E+ GQV GYHKPIMIAGG+G+I A+ T Sbjct: 367 LDIMIEGPIGGAAFNNEFGRPNLLGYFRTFEEKFDGQVRGYHKPIMIAGGLGSIQAQQTH 426 Query: 425 KNDLPVGSLLIQLGGPGMRIGMGGGAASSMATGVNAADLDFDSVQRGNPEMERRAQEVIN 484 K+++P G+LLIQLGGPGM IG+GGGAASSM TG N A LDF+SVQRGNPE+ERRAQEVI+ Sbjct: 427 KDEIPEGALLIQLGGPGMLIGLGGGAASSMDTGTNDASLDFNSVQRGNPEIERRAQEVID 486 Query: 485 ACWALGDDNPIQSIHDVGAGGLSNAFPEITNDAKRGAIFDLRKVPLEESGLAPREIWSNE 544 CW LGD NPI SIHDVGAGGLSNAFPE+ NDA RGA+F LR+VPLEE GL P +IW NE Sbjct: 487 RCWQLGDKNPIISIHDVGAGGLSNAFPELVNDAGRGAVFKLREVPLEEHGLNPLQIWCNE 546 Query: 545 SQERYVLAILPEHLELFKYLCERERAPFAVVGTATEERQLKVIDPEHNNSPVDMPMDVLL 604 SQERYVL+IL + L++F+ +CERER PFAVVGTAT++ LKV D +N+PVD+P++VLL Sbjct: 547 SQERYVLSILEKDLDIFRSICERERCPFAVVGTATDDGHLKVRDDLFSNNPVDLPLNVLL 606 Query: 605 GKPPKMHRDVTHVEKQLPPVDLTGMDLVEVAQRVLRLPAVADKSFLITIGDRSVGAMTVR 664 GKPPK R V P +D+ E A RVLRLPAVA K+FLITIGDRSVG MT R Sbjct: 607 GKPPKTTRTDKTVAPSKKPFHAGDIDITEAAYRVLRLPAVAAKNFLITIGDRSVGGMTHR 666 Query: 665 DQMVGPWQVPVADVAVTAMGLEGYRGEAMAMGERTPLAVIDAPASGRMAVGEAITNIAAA 724 DQMVG +Q PVAD AVT MG YRGEAM+MGE+ +A+ DAPASGRM VGEAITNIAAA Sbjct: 667 DQMVGKYQTPVADCAVTMMGFNTYRGEAMSMGEKPTVALFDAPASGRMCVGEAITNIAAA 726 Query: 725 PIAEIGDIKLSANWMAACGQPGQDAALFDTVKAVGMELCPALGVSIPVGKDSLSMRSTWS 784 I +IG+IKLSANWMAACG G+D L+ TV+AV + C AL +SIPVGKDSLSM++ W Sbjct: 727 NIGDIGNIKLSANWMAACGNEGEDEKLYRTVEAVS-KACQALDLSIPVGKDSLSMKTVWQ 785 Query: 785 DEEGAKSVTSPVSLIVSGFAPVTDVRRVLTPQLRKDKGETVLILIDLGRGKNRMGASALT 844 D E KSV SP+SLI+S FAPV DVR+ +TP+L K+ ++VL+ +DLG GK RMG SA Sbjct: 786 DGEEKKSVVSPLSLIISAFAPVQDVRKTVTPEL-KNVEDSVLLFVDLGFGKARMGGSAFG 844 Query: 845 QVMQQIGNETPDVDSADDLKAFFNAIQQLNTEDRLLAYHDRSDGGLYATLAEMAFAGHTG 904 QV + + PD+D LKAF+N IQQL ED+LLAYHDRSDGGL+A L EMAFAG G Sbjct: 845 QVYNNMSGDAPDLDDTSRLKAFYNVIQQLVAEDKLLAYHDRSDGGLFAVLVEMAFAGRCG 904 Query: 905 ISVNLDIL---TMEGEHAADWGDSKNWTTQVAERRNELTLRALFSEELGAVIQVPAEQKS 961 + ++L++L T H A + + E R LF+EELGAVIQV + + Sbjct: 905 LDIDLNLLLAQTFITNHTALSQSLRTEEVKALAEWQETIARTLFNEELGAVIQVRKQDVA 964 Query: 962 DVMNVLRSYNLGACSHIIGKPNDRDVIEFMRDAK 995 D++N+ L IG D + + +RD + Sbjct: 965 DIINLFYQQQLHHNVFEIGTLTDENTL-IIRDGQ 997