BLASTP 2.2.21 [Jun-14-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Query= 0022.0004.p (224 letters) Database: COGmodified 192,987 sequences; 59,019,183 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value Rv0101_3 [Q] COG1020 Non-ribosomal peptide synthetase modules an... 119 4e-27 MT0110_3 [Q] COG1020 Non-ribosomal peptide synthetase modules an... 119 4e-27 PA2402_1 [Q] COG1020 Non-ribosomal peptide synthetase modules an... 116 4e-26 PA2424_3 [Q] COG1020 Non-ribosomal peptide synthetase modules an... 114 1e-25 BS_dhbF [Q] COG1020 Non-ribosomal peptide synthetase modules and... 114 2e-25 >Rv0101_3 [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins Mtu Mycobacterium tuberculosis H37Rv Length = 1080 Score = 119 bits (299), Expect = 4e-27, Method: Compositional matrix adjust. Identities = 74/180 (41%), Positives = 99/180 (55%), Gaps = 4/180 (2%) Query: 1 LTQAQQGLWLTWQLQPDSAAYNLAGVLDLCGELQVEALEDALCDLAARHAALRTLFPLRD 60 L+ AQ+ LW QLQ + YN+A L L G L EAL A+ D+ RH +LRT+FP D Sbjct: 5 LSFAQRRLWFLDQLQRPAPVYNMAVALRLRGYLDTEALGAAVADVVGRHESLRTVFPAVD 64 Query: 61 GTPVQQVLDIDEARPMLLRSDLRRQPADKRAQAAASALQRFHAQAFRLDSETPLRAMLVQ 120 G P Q V++ A D PAD+ +A A + +F L +E PLR L + Sbjct: 65 GVPRQLVIEARRADLGCDIVDATAWPADRLQRAIEEAAR----HSFDLATEIPLRTWLFR 120 Query: 121 LEAHHFRLGLCIHHIAADGWSLGIILDELTAAYEARCAGAAPSWPALELQPGDYAVWQRQ 180 + L HHIAADGWS+ + +L+AAY +RCAG AP W L +Q DY +WQR+ Sbjct: 121 IADDEHVLVAVAHHIAADGWSVAPLTADLSAAYASRCAGRAPDWAPLPVQYVDYTLWQRE 180 >MT0110_3 [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins MtC Mycobacterium tuberculosis CDC1551 Length = 1091 Score = 119 bits (299), Expect = 4e-27, Method: Compositional matrix adjust. Identities = 74/180 (41%), Positives = 99/180 (55%), Gaps = 4/180 (2%) Query: 1 LTQAQQGLWLTWQLQPDSAAYNLAGVLDLCGELQVEALEDALCDLAARHAALRTLFPLRD 60 L+ AQ+ LW QLQ + YN+A L L G L EAL A+ D+ RH +LRT+FP D Sbjct: 7 LSFAQRRLWFLDQLQRPAPVYNMAVALRLRGYLDTEALGAAVADVVGRHESLRTVFPAVD 66 Query: 61 GTPVQQVLDIDEARPMLLRSDLRRQPADKRAQAAASALQRFHAQAFRLDSETPLRAMLVQ 120 G P Q V++ A D PAD+ +A A + +F L +E PLR L + Sbjct: 67 GVPRQLVIEARRADLGCDIVDATAWPADRLQRAIEEAAR----HSFDLATEIPLRTWLFR 122 Query: 121 LEAHHFRLGLCIHHIAADGWSLGIILDELTAAYEARCAGAAPSWPALELQPGDYAVWQRQ 180 + L HHIAADGWS+ + +L+AAY +RCAG AP W L +Q DY +WQR+ Sbjct: 123 IADDEHVLVAVAHHIAADGWSVAPLTADLSAAYASRCAGRAPDWAPLPVQYVDYTLWQRE 182 >PA2402_1 [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins Pae Pseudomonas aeruginosa Length = 1541 Score = 116 bits (290), Expect = 4e-26, Method: Compositional matrix adjust. Identities = 76/197 (38%), Positives = 101/197 (51%), Gaps = 8/197 (4%) Query: 1 LTQAQQGLWLTWQLQPDSAAYNLAGVLDLCGELQVEALEDALCDLAARHAALRTLFPL-R 59 L+ AQQ +W W L+P S AYNL + L G L +ALE A L RH LRT+FP Sbjct: 52 LSYAQQRMWFLWHLEPQSGAYNLPSAVRLNGPLDRQALERAFASLVQRHETLRTVFPRGA 111 Query: 60 DGTPVQQVLDIDEARPM-LLRSDLRRQPADKRAQAAASALQRFHAQAFRLDSETPLRAML 118 D + Q L RP+ + D P D++ QR Q F L LR L Sbjct: 112 DDSLAQAPLQ----RPLEVAFEDCSGLPEDEQEARLREEAQRESLQPFDLCEGPLLRVRL 167 Query: 119 VQLEAHHFRLGLCIHHIAADGWSLGIILDELTAAYEARCAGAAPSWPALELQPGDYAVWQ 178 ++L L L +HHI +DGWS+ ++++E + Y A GA P PAL +Q DYA+WQ Sbjct: 168 IRLGEERHVLLLTLHHIVSDGWSMNVLIEEFSRFYSAYATGAEPGLPALPIQYADYALWQ 227 Query: 179 RQRSQPGSPEFQRQLDY 195 R + G E RQL+Y Sbjct: 228 RSWLEAGEQE--RQLEY 242 >PA2424_3 [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins Pae Pseudomonas aeruginosa Length = 1520 Score = 114 bits (286), Expect = 1e-25, Method: Compositional matrix adjust. Identities = 79/203 (38%), Positives = 103/203 (50%), Gaps = 14/203 (6%) Query: 1 LTQAQQGLWLTWQLQPDSAAYNLAGVLDLCGELQVEALEDALCDLAARHAALRTLFPLRD 60 L+ +QQ +W WQL+PDS AYN+ G+ L G L V E AL L RH LRT FP D Sbjct: 11 LSYSQQRMWFLWQLEPDSPAYNVGGLARLSGPLDVARFEAALQALVQRHETLRTTFPSVD 70 Query: 61 GTPVQQV-----LDIDEARPMLLRSDLRRQPADKRAQAAASALQRFHAQAFRLDSETPLR 115 G PVQ+V L +D L D R+Q A + A + F L+S LR Sbjct: 71 GVPVQRVHGDGGLHMDWQDFSALDRDSRQQHLQTLADSEAH-------RPFDLESGPLLR 123 Query: 116 AMLVQLEAHHFRLGLCIHHIAADGWSLGIILDELTAAYEARCAGAAPSWPALELQPGDYA 175 +V++ L + +HHI +GW++ I EL A YEA L +Q DY+ Sbjct: 124 VCMVKMAEREHYLVVTLHHIVTEGWAMDIFARELGALYEAFLDDRESPLEPLPVQYLDYS 183 Query: 176 VWQRQRSQPGSPEFQRQLDYXAA 198 VWQR+ + G E QRQLDY A Sbjct: 184 VWQREWLESG--ERQRQLDYWKA 204 >BS_dhbF [Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins Bsu Bacillus subtilis Length = 1278 Score = 114 bits (285), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 70/181 (38%), Positives = 100/181 (55%), Gaps = 9/181 (4%) Query: 1 LTQAQQGLWLTWQLQPDSAAYNLAGVLDLCGELQVEALEDALCDLAARHAALRTLFPLRD 60 L+ AQ+ LW L+ S YN+ + L GEL L+ AL DL RH +LRT+FP Sbjct: 1053 LSFAQRRLWFLHCLEGPSPTYNIPVAVRLSGELDQGLLKAALYDLVCRHESLRTIFPESQ 1112 Query: 61 GTPVQQVLDIDEARPMLLRSDL-RRQPADKRAQAAASALQRFHAQAFRLDSETPLRAMLV 119 GT Q +LD D A P L +++ ++ +D+ A+A R+ +F L +E RA L Sbjct: 1113 GTSYQHILDADRACPELHVTEIAEKELSDRLAEAV-----RY---SFDLAAEPAFRAELF 1164 Query: 120 QLEAHHFRLGLCIHHIAADGWSLGIILDELTAAYEARCAGAAPSWPALELQPGDYAVWQR 179 + + L L +HHI DGWSL + +L AY ARC G +P W L +Q DYA+WQ+ Sbjct: 1165 VIGPDEYVLLLLVHHIVGDGWSLTPLTRDLGTAYAARCHGRSPEWAPLAVQYADYALWQQ 1224 Query: 180 Q 180 + Sbjct: 1225 E 1225